Podcasts about observational

Play Episode Listen Later Nov 9, 2025 47:43

We continue our work on Isaiah 45

Real Talk: Eosinophilic Diseases

MCAT Psych/Soc Masterclass: Learning & Conditioning I Jack Westin MCAT Podcast

Jack Westin MCAT Podcast

Play Episode Listen Later Nov 4, 2025 71:16

Level up your MCAT Psych/Soc with the part 2 of masterclass on learning & conditioning, the way AAMC now tests it. Mike & Molly cover the exact strategies to read passages like CARS, not a terms quiz.What you'll learnClassical conditioning: US/UR, CS/CR, generalization, discrimination, extinction & spontaneous recoveryOperant conditioning: reinforcement vs punishment, positive vs negative (with real-life examples)Reinforcement schedules: fixed/variable × ratio/interval (why VR resists extinction)Observational learning: Bobo doll, mirror neurons, media effectsNon-associative learning: habituation, sensitization, dishabituation, desensitizationIf this helped, subscribe and catch next week's Data Interpretation Deep Dive.Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!

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Anarchist Audit Observational Science Dungeons and Dragons and Mental Health Dr. Dean Lloyd

Toward Anarchy

Play Episode Listen Later Nov 1, 2025 114:20

Science is a bit like fiction, there are parts of it that are real and familiar but the rest of it seems more like some show we're all streaming on our phones. In the second hour Healer and Facilitator Dr. Dean Lloyd joins me to talk about Paradoxes

science mental health brain fiction paradoxes healers dungeons and dragons mental illness musicians audit anarchy orwell anarchists health dr observational simulated universe

TSLP and EoE: Exploring the Science Behind a Potential Treatment Target

Play Episode Listen Later Oct 29, 2025 33:10

Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Dr. Andrew Lee, Vice President, Clinical Research at Uniquity Bio, about Thymic Stromal Lymphopoietin (TSLP) and eosinophilic esophagitis (EOE). Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own. Key Takeaways: [:49] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz. [1:13] Holly introduces today's topic, Thymic Stromal Lymphopoietin (TSLP) and eosinophilic esophagitis (EOE), and today's guest, Dr. Andrew Lee, Vice President, Clinical Research at Uniquity Bio. [1:36] Dr. Lee has nearly 20 years of experience in the clinical development of new vaccines, biologics, and drugs. Holly welcomes Dr. Lee. [1:52] Dr. Lee trained in internal medicine and infectious diseases. [1:58] Dr. Lee has been fascinated by the immune system and how it can protect people against infections, what happens when immunity is damaged, as in HIV and AIDS, and how to apply that knowledge to boost immunity with vaccines to prevent infections. [2:16] Dr. Lee led the clinical development for a pediatric combination vaccine for infants and toddlers. It is approved in the U.S. and the EU. [2:29] Dr. Lee led the Phase 3 Program for a monoclonal antibody to prevent RSV, a serious infection in infants. That antibody was approved in June 2025 for use in the U.S. [2:44] In his current company, Dr. Lee leads research into approaches to counteract an overactive immune system. They're looking at anti-inflammatory approaches to diseases like asthma, EoE, and COPD. [2:58] Dr. Lee directs the ongoing Phase 2 studies that they are running in those areas. [3:28] Dr. Lee sees drug development as a chance to apply cutting-edge research to benefit people. He trained at Bellevue Hospital in New York City in the 1990s. [3:40] When Dr. Lee started as an intern, there were dedicated ICU wards for AIDS patients because many of the sickest patients were dying of AIDS and its complications. [3:52] Before the end of Dr. Lee's residency, they shut down those wards because the patients were on anti-retroviral medications and were doing so well that they were treated as outpatients. They didn't need dedicated ICUs for AIDS patients anymore. [4:09] For Dr. Lee, that was a powerful example of how pharmaceutical research and drug regimen can impact patients' lives for the better by following the science. That's what drove Dr. Lee to go in the direction of research. [4:48] Dr. Lee explains Thymic Stromal Lymphopoietin (TSLP). TSLP serves as an alarm signal for Type 2 or TH2 inflammation, a branch of the immune responses responsible for allergic responses and also immunity against parasites. [5:17] When the cells that line the GI tract and the cells that line the airways in our lungs receive an insult or an injury, they get a danger signal, then they make TSLP. [5:28] This signal activates other immune cells, like eosinophils and dendritic cells, which make other inflammatory signals or cytokines like IL-4, IL-13, and IL-5. [5:47] That cascade leads to inflammation, which is designed to protect the body in response to the danger signal, but in some diseases, when there's continued exposure to allergens or irritants, that inflammation goes from being protective to being harmful. [6:15] That continued inflammation, over the years, can lead to things like the thickened esophagus with EoE, or lungs that are less pliant and less able to expand, in respiratory diseases. [6:48] Dr. Lee says he thinks of TSLP as being a master switch for this branch of immune responses. If you turn on TSLP, that turns on a lot of steps that lead to generating an allergic type of response. [7:06] It's also the same type of immune response that can fight off parasite infections. It's the first step in a cascade of other steps generating that type of immune response. [7:30] Dr. Lee says people have natural genetic variation in the genes that incur TSLP. [7:38] Observational studies have found that some people with genetic variations that lead to higher levels of TSLP in their bodies had an increased risk for allergic inflammatory diseases like EoE, atopic dermatitis, and asthma. [8:13] Studies like the one just mentioned point to TSLP being important for increased risk of developing atopic types of diseases like EoE and others. There's been some work done in the laboratory that shows that TSLP is important for activating eosinophils. [8:38] There's accumulating evidence that TSLP activation leads to eosinophil activation, other immune cells, or white blood cells getting activated. [9:07] Like a cascade, those cells turn on T-cells and B-cells, which are like vector cells. They lead to direct responses to fight off infections, in case that's the signal that leads to the turning on TSLP. [9:48] Ryan refers to a paper published in the American Journal of Gastroenterology exploring the role of TSLP in an experimental mouse model of eosinophilic esophagitis. Ryan asks what the researchers were aiming to find. [10:00] Dr. Lee says the researchers were looking at the genetic studies we talked about, the observational studies that are beginning to link more TSLP with more risk for EoE and those types of diseases. [10:12] The other type of evidence that's accumulating is from in vitro (in glass) experiments or test tube experiments, where you take a couple of cells that you think are relevant to what's going on. [10:28] For example, you could get some esophageal cells and a couple of immune cells, and put TSLP into the mix, and you see that TSLP leads to activation of those immune cells and that leads to some effects on the esophageal cells. [10:42] Those are nice studies, but they're very simplified compared to what you can do in the body. These researchers were interested in extending those initial observations from other studies, but working in the more realistic situation of a mouse model. [11:00] You have the whole body of the mouse being involved. You can explore what TSLP is doing and model a disease that closely mimics what's happening with EoE in humans. [12:23] They recreated the situation of what seems to be happening in EoE in people. We haven't identified it specifically, but there's some sort of food allergen in patients with EoE that the immune system is set off by. [12:55] What researchers are observing in this paper is that in these mice that were treated with oxazolone, there is inflammation in the esophagus, an increase in TSLP levels, and eosinophils going into the esophageal tissues. [13:15] Dr. Lee says, that's one of the main ways we diagnose EoE; we take a biopsy of the esophagus and count how many eosinophils there are. Researchers saw similar findings. The eosinophil count in the esophageal tissues went way up in these mice. [13:34] Researchers also saw other findings in these mice that are very similar to EoE in humans, such as the esophageal cells lining the esophagus proliferating. They even saw that new blood vessels were being created in that tissue that's getting inflamed. [14:00] Dr. Lee thinks it's a very nice paper because it shows that correlation: Increase TSLP and you see these eosinophils going to the esophagus, and these changes that are very reminiscent of what we see in people with EoE. [14:51] In this paper, the mice made the TSLP, and researchers were able to measure the TSLP in the esophageal tissue. The researchers didn't introduce TSLP into the mice. The mice made the TSLP in response to being repeatedly exposed to oxazolone. [15:20] That's key to the importance of the laboratory work. The fact that the TSLP is made by the mice is important. It makes it a very realistic model for what we're seeing in people. [15:41] In science, we like to see correlation. The researchers showed a nice correlation. [15:46] When TSLP went up in these mice, and the mice were making more TSLP on their own, at the same time, they saw all these changes in the esophagus that look a lot like what EoE looks like in people. [16:01] They saw the eosinophils coming into the esophagus. They saw the inflammation go up in the esophagus. What Dr. Lee liked about this paper is that they continued the story. [16:15] The researchers took something that decreases TSLP levels, an antibody that binds to and blocks TSLP, and when they did that, they saw the TSLP levels come down to half the peak level. [16:35] Then they saw improvement in the inflammation in the esophagus. They saw that the amount of eosinophils decreased, and the multiplication of the esophageal cells went down. The number of new blood vessels went down after the TSLP was reduced. [16:53] Dr. Lee says, you see correlation. The second part is evidence for causation. When you take TSLP away, things get better. That gives us a lot of confidence that this is a real finding. It's not just observational. There is causation evidence here. [18:26] Ryan asks if cutting TSLP also help reduce other immune response cells. Dr. Lee says TSLP is the master regulator for this Type 2 inflammation. It definitely touches and influences other cells besides eosinophils. [18:44] TSLP affects dendritic cells, which are an important type of immune cell, like a coordinating cell that instructs other cells within the immune system what to do. In this paper, they looked at a lot of other effects of TSLP on the tissues of the body. [19:10] Dr. Lee says, There's a lot of research on TSLP, and one of the reasons we're excited about the promise of TSLP is that it's so far upstream; so much of the beginning, that it's affecting other cells. [19:29] Its effects could be quite broad. If we're able to successfully block TSLP, we could block a lot of different effects. [19:40] One treatment for EoE is dupilumab, which blocks IL-4 and IL-13 specifically, and that works well, but TSLP has the potential to have an even greater effect than blocking IL-4 and IL-13, since it is one step before turning on IL-4 and IL-13. [20:14] That's one of the reasons researchers are excited about the promise of blocking TSLP. There are studies ongoing of TSLP blockers in people with EoE. [20:34] Ryan asks if there are negative repercussions from blocking TSLP. Dr. Lee says in this study and in people, we are not completely blocking TSLP by any means. There will still be residual TSLP activated, even with very potent drugs. [21:01] In the study, they block TSLP about 50%‒60%. TSLP is involved in immunity against parasites. In studies with people, they make sure not to include anybody who has an active parasitic infection. A person under treatment should not be in a study. [21:27] Dr. Lee says we haven't seen any problems with parasitic infections becoming more severe, but that is a theoretical possibility, so for that reason, in studies with TSLP blockers, we generally exclude patients with known parasitic infections. [22:17] What excited Dr. Lee in this paper was that they showed that when you block TSLP in the mice, then you get real effects in their tissues. Eosinophils went away. The thickening of the basal layers in the esophagus got much better. [22:38] That kind of real effect reflected in the tissue is super exciting to see. That gives us more confidence that this could work in people, since we're seeing it in a realistic whole-body model in the mice. [23:12] Dr. Lee says there are ongoing clinical studies on TSLP blockers for EoE. His company is studying an antibody that blocks TSLP in eczema, COPD, and EoE. One of the exciting things about immunology is that it affects many different parts of the body. [23:42] EoE is associated with other immune-type disorders. There's a high percentage of patients with EoE who have other diseases. EoE coexists with asthma, atopic dermatitis, and chronic rhinitis. [24:09] It's exciting that if you figure out something that's promising for one disease that TSLP affects, it could have very broad-ranging implications for a variety of diseases. [24:22] Ryan shares his experience of his doctor talking to him about a TSLP blocker, tezepelumab, as a potential option when it's out of clinical trials. It would target something a little higher up the chain and help with some of his remaining symptoms. [24:59] Ryan is excited to hear that this research is so encouraging and how it could potentially help treat EoE, asthma, and other conditions, all at once. [25:16] Dr. Lee says that being in these later-stage studies is super exciting. If these late-stage trials are successful, the next step is to apply for regulatory approval with the various agencies around the world. [26:40] Dr. Lee shares one takeaway for listeners to remember. Think of TSLP as an alarm that turns on inflammation. He compares TSLP to turning on an alarm during a robbery. There are multiple steps designed to protect the bank and the money. [27:20] To extend that analogy, with TSLP, once you turn it on, all these other steps are going to happen. Inflammation is designed to protect the body. It's a protective response. If there's an infection, it can clear the infection. [27:38] If the infection persists, as in HIV, the immune response, which is protective and beneficial, eventually becomes damaging. It becomes dysfunctional. In EoE, if you continually eat the allergic food, the inflammation becomes damaging to the esophagus. [28:27] Long-term inflammation leads to replacing the normal esophageal tissue with fibrotic tissue, and that's why the esophagus eventually gets hardened and less able to let the food go through. [28:40] In respiratory diseases, the soft tissue of the lung gets replaced with thicker tissue, and the lung is not able to expand. [28:54] Dr. Lee says he people to think about TSLP as this master alarm switch. We hope that if you could turn off that TSLP, you could then avoid a lot of the complications that we see with chronic inflammation in these conditions. [29:14] We're hopeful that you could even take away the symptoms that you see in these diseases, make patients feel better, and with extended treatment, you could begin to reverse some of the damage resulting from inflammation. [29:32] Ryan likes that analogy and how Dr. Lee has concisely explained these complicated concepts. [29:51] Dr. Lee thanks Holly and Ryan and adds one more plea to listeners. Please consider getting involved with research. Clinical trials cannot be done without patients. We need patients to advance new treatments. [30:27] Researchers like Dr. Lee spend a lot of time thinking about how to make the studies not only informative but also fair to patients who decide to become involved. It's a lot of work and a fair amount of time commitment. [30:44] If you don't want to be in a study, you can help by being on a patient feedback panel and reviewing protocols and informed consents. Follow your interests. Think about getting involved with research, however you can. [31:06] Ryan and Holly are very grateful for the community, with so many wonderful clinicians and researchers, and so many patients who are willing to volunteer their time and their data to help researchers find better solutions going forward. [31:26] Ryan thanks Dr. Lee for coming on and putting out that call to action. It's a great reminder for listeners and the patients in the community to look for those opportunities. Chat with your physician. Go to APFED's website. There's a link to active clinical trials. [31:47] For our listeners who want to learn more about eosinophilic disorders, we encourage you to visit apfed.org and check out the links in the show notes below. [31:53] For those looking to find specialists who treat eosinophilic disorders, we encourage you to use APFED's Specialist Finder at apfed.org/specialist. [32:01] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections. [32:11] Ryan thanks Dr. Andrew Lee for joining us today. We learned a lot. Holly also thanks APFED's Education Partners Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda for supporting this episode. Mentioned in This Episode: Andrew Lee, M.D., VP Clinical Research, Uniquity Bio "A Mouse Model for Eosinophilic Esophagitis (EoE)" Current Protocols, Wiley Online Library APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections apfed.org/research/clinical-trials Education Partners: This episode of APFED's podcast is brought to you thanks to the support of Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda. Tweetables: "I see drug development as a chance to apply cutting-edge research to benefit people." — Andrew Lee, M.D. "When the cells that line the GI tract and the cells that line the airways in our lungs receive an insult or an injury, they get a danger signal, then they make TSLP." — Andrew Lee, M.D. "Observational studies have found that some people with genetic variations that lead to higher levels of TSLP in their bodies had an increased risk for allergic inflammatory diseases like EoE, atopic dermatitis, and asthma." — Andrew Lee, M.D. "There's a lot of research on TSLP, and one of the reasons we're excited about the promise of TSLP is that it's so far upstream; so much of the beginning, that it's affecting other cells." — Andrew Lee, M.D. "Please consider getting involved with research. We can't do these clinical trials without patients. We need patients to advance new treatments for patients." — Andrew Lee, M.D.

Isaiah 45: Observational Outline Pt 2

Play Episode Listen Later Oct 26, 2025 55:53

We continue building an observational outline on Isaiah 45

Isaiah 45: Observational Outline Pt 2

Play Episode Listen Later Oct 26, 2025 55:52

We continue building an observational outline on Isaiah 45

Isaiah 45: Observational Outline Pt 1

Play Episode Listen Later Oct 19, 2025 54:24

We begin building an observational outline of Isaiah 45

Isaiah 45: Observational Outline Pt 1

Play Episode Listen Later Oct 19, 2025 54:23

We begin building an observational outline of Isaiah 45

canada canadian comedians norm macdonald second city rat race rowan atkinson comedian actor observational wry stollery

Episode 90: Comedian/Actor-Brian Stollery

In The Wry Podcast

Play Episode Listen Later Oct 9, 2025 70:17 Transcription Available

Canadian comedian/actor Brian Stollery joins the podcast for this episode to talk about his acting career, Second City, Norm MacDonald, differences between stand up in Canada and the U.S., working with Rowan Atkinson in Rat Race, and more!Brian Stollery rarely waits more than a heartbeat before inviting his audiences to have a laugh at his expense. Observational, autobiographical and hilariously self-deprecating, Brian Stollery's brand of comedy reveals the underlying absurdity of everyday life in a way that is as scathingly honest as it is fast paced and energetic. Mr. Stollery has spent more than twenty years mining the stuff of everyday life for laughs in a way that is universal and unique. His quick-witted delivery covers a variety of topics flowing effortlessly from one bit to another. Brian's material is current, ensuring he covers the latest trends and events both from his life and the world. His clever word play and witty commentary on life delights audiences wherever he performs.https://thecomedian.ca/

Ep 826 - Observational Comedy Haikus

the evening almanac

Play Episode Listen Later Oct 7, 2025 8:00

I do some haikus (no, really), tell some jokes (I'm a comedian), and we also talk about Chris Langan, the most intelligent man in the world, and his theory of reality called CTMU (no, really really). Essentially.

comedy observational haikus

Clinical Challenges in Trauma Surgery: Stabbed in the Back - Decision Making in a Penetrating Junctional Vascular Injury

Behind The Knife: The Surgery Podcast

Play Episode Listen Later Sep 29, 2025 33:53

“It's 5pm and your Consultant (attending) has headed off home. A patient arrives in the resuscitation room blood spurting from a stab wound in the armpit. Join Roisin – a junior Major Trauma fellow, Prash – a surgical trainee, Max – a senior trauma surgery fellow, and Chris – a Consultant trauma surgeon, as we talk through decision making from point of injury to aftercare in this challenging trauma surgical case”. • Hosts: Bulleted list of host names, including title, institution, & social media handles if indicated 1. Mr Prashanth Ramaraj. General Surgery trainee, Edinburgh rotation. @LonTraumaSchool 2. Dr Roisin Kelly. Major Trauma Junior Clinical Fellow, Royal London Hospital. 3. Mr Max Marsden. Resuscitative Major Trauma Fellow, Royal London Hospital. @maxmarsden83 4. Mr Christopher Aylwin. Consultant Trauma & Vascular Surgeon and Co-Programme Director MSc Trauma Sciences at Queen Mary University of London. @cjaylwin • Learning objectives: Bulleted list of learning objectives. A) To become familiar with prehospital methods of haemorrhage control in penetrating junctional injuries. B) To recognise the benefits of prehospital blood product resuscitation in some trauma patients. C) To follow the nuanced decision making in decision for CT scan in a patient with a penetrating junctional injury. D) To describe the possible approaches to the axillary artery in the context of resuscitative trauma surgery. E) To become familiar with decision making around intraoperative systemic anticoagulation in the trauma patient. F) To become familiar with decision making on type of repair and graft material in vascular trauma. G) To recognise the team approach in holistic trauma care through the continuum of trauma care. • References: Bulleted list of references with PubMed links. 1. Perkins Z. et al., 2012. Epidemiology and Outcome of Vascular Trauma at a British Major Trauma Centre. EJVES. https://www.ejves.com/article/S1078-5884(12)00337-1/fulltext 2. Ramaraj P., et al. 2025. The anatomical distribution of penetrating junctional injuries and their resource implications: A retrospective cohort study. Injury. https://www.injuryjournal.com/article/S0020-1383(24)00771-X/ 3. Smith, S., et al. 2019. The effectiveness of junctional tourniquets: A systematic review and meta-analysis. J Trauma Acute Care Surg. https://journals.lww.com/jtrauma/abstract/2019/03000/the_effectiveness_of_junctional_tourniquets__a.20.aspx 4. Rijnhout TWH, et al. 2019. Is prehospital blood transfusion effective and safe in haemorrhagic trauma patients? A systematic review and meta-analysis. Injury. https://www.injuryjournal.com/article/S0020-1383(19)30133-0/ 5. Davenport R, et al. 2023. Prehospital blood transfusion: Can we agree on a standardised approach? Injury. https://www.injuryjournal.com/article/S0020-1383(22)00915-9. 6. Borgman MA., et al. 2007. The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital. J Trauma Acute Care Surg. https://journals.lww.com/jtrauma/fulltext/2007/10000/the_ratio_of_blood_products_transfused_affects.13.aspx 7. Holcomb JB., et al. 2013. The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study. Comparative Effectiveness of a Time-Varying Treatment With Competing Risks. JAMA Surgery. https://jamanetwork.com/journals/jamasurgery/fullarticle/1379768 8. Holcomb JB, et al. 2015. Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma. The PROPPR Randomized Clinical Trial. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2107789 9. Davenport R., et al. 2023. Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury. The CRYOSTAT-2 Randomized Clinical Trial. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2810756 10. Baksaas-Aasen K., et al. 2020. Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial. ICM. https://link.springer.com/article/10.1007/s00134-020-06266-1 11. Wahlgren CM., et al. 2025. European Society for Vascular Surgery (ESVS) 2025 Clinical Practice Guidelines on the Management of Vascular Trauma. EJVES. https://esvs.org/wp-content/uploads/2025/01/2025-Vascular-Trauma-Guidelines.pdf 12. Khan S., et al. 2020. A meta-analysis on anticoagulation after vascular trauma. Eur J Traum Emerg Surg. https://link.springer.com/article/10.1007/s00068-020-01321-4 13. Stonko DP., et al. 2022. Postoperative antiplatelet and/or anticoagulation use does not impact complication or reintervention rates after vein repair of arterial injury: A PROOVIT study. Vascular. https://journals.sagepub.com/doi/10.1177/17085381221082371?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

The Elephant in the Universe: 100-year search for dark matter Author: Govert Schilling Theoretical Stability and Observational Proof of Dark Matter Halos

The John Batchelor Show

Play Episode Listen Later Sep 6, 2025 10:20

The Elephant in the Universe: 100-year search for dark matter Author: Govert Schilling Theoretical Stability and Observational Proof of Dark Matter Halos Headline: Galaxies Need Invisible Halos: Ostriker and Rubin Provide Evidence In the late 1960s, theorist Jeremiah Ostriker calculated that a flattened galaxy like the Milky Way could not remain stable without a large, spherical "halo" of unseen matter surrounding it, providing a theoretical basis for dark matter. This theoretical need was then powerfully confirmed by the observational work of American astronomer Vera Rubin and her colleague Kent Ford throughout the 1970s. Studying distant galaxies, including Andromeda, they discovered that stars on the outer edges rotated at unexpectedly high, constant velocities, rather than slowing down as predicted. This "flattening the curve" of rotational velocities offered the first concrete proof for the existence of dark matter, whose gravity was necessary to prevent galaxies from flying apart. 1958

american search universe proof elephants studying stability dark matter milky way andromeda theoretical halos observational vera rubin govert schilling

Comets in Astrology

The Astrology Podcast

Play Episode Listen Later Aug 15, 2025 114:07

In episode 503 of The Astrology Podcast astrologer Rod Chang joins me to discuss the long and fascinating history of comets in astrology, how astrologers viewed them as omens in ancient times, and creating a new foundation for interpreting them today. While comets are a notable astronomical phenomenon and are famous in legends from ancient times as powerful omens, there has been very little discussion about their meaning or use in modern astrology. Part of the reason for this is that they appear so infrequently, are difficult to calculate, and are not included in most astrology software, which has led to them being largely overlooked by contemporary astrologers. We begin the discussion by exploring the long history of comets in astrology, noting the contrast between the Western tradition and the Chinese tradition. In the West, research into comets was set back for centuries by Aristotle's mistaken belief that they were merely atmospheric phenomena. In the Chinese tradition, however, comets were meticulously documented for thousands of years, where they were often referred to as "broom stars" that could sweep away the old government or indicate the need for reform. This eventually led to a rich history of astrological interpretation, which we are only now beginning to recover and understand. During the course of the episode we talk about what comets are from an astronomical perspective, as well as how their erratic and unpredictable nature became a key part of their astrological interpretation. Traditionally comets were interpreted as omens that signified major disruptions, the death of prominent people, and important turning points in history. Their meaning was often derived from their visual appearance, such as their color or the shape of their tail. While often viewed as negative omens that coincided with natural disasters or the death of rulers, there are also instances where they were interpreted positively. Towards the end of the episode we discuss how contemporary astrologers are now in a much better position to study comets, with new tools that allow us to calculate their positions and go back and research what was happening in the world when major comets appeared in the past. This is a large part of the focus of Rod's new book titled Comets in Astrology, where he identifies some of the most important "Great Comets" in history and documents the events that coincided with their appearance. We hope that this discussion provides a good foundation for a subject that will become an exciting new area of research in astrology in the years to come. Rod's book was just released August 13, and you can get it now: Comets in Astrology on Amazon You can find out more information about Rod on his website: RodChang.com This episode is available in both audio and video versions below. Timestamps 00:00:00 Introduction 00:01:05 Rod's journey into studying comets 00:02:40 Why comets are overlooked in modern astrology 00:07:09 What is a comet? 00:10:04 Short-period vs. long-period comets 00:16:55 Erratic and unpredictable quality of comets 00:19:18 Aristotle's error vs. Chinese documentation 00:24:30 Edmond Halley, Brahe, and Kepler 00:28:58 Recent comets: Pons-Brooks 00:33:52 Decline of astrology hindered comet research 00:36:39 Researching historical comets and mundane events 00:39:01 What defines a “Great Comet” 00:51:04 Chinese “broom stars” and political significance 01:01:06 Comets as omens 01:11:47 Death of prominent people 01:15:02 Mark Twain and Halley's Comet 01:25:52 Observational astronomy 01:36:18 Comet's tail and directionality 01:40:03 Positive interpretations of comets 01:43:27 Setting a foundation for comet research 01:48:11 Rod's upcoming work, website, and classes 01:51:29 Concluding remarks Watch the Video Version of This Episode https://www.youtube.com/watch?v=U-UtgNIRCnY –

Ep. 153 Crossover Episode: What Simulation Reveals About Pediatric Readiness in EMS

Prehospital Emergency Care Podcast - the NAEMSP Podcast

Play Episode Listen Later Aug 13, 2025 50:11

How well do EMS teams manage critically ill pediatric patients—and how do we know? In this special crossover episode with the EMS Educator Podcast, hosts Rob Lawrence and Maia Dorsett speak with Mark Cicero, lead author of a landmark study published in Prehospital Emergency Care. The study used simulation to assess EMS performance in pediatric emergencies. From medication dosing errors to missed fundamentals like cap refill checks, Dr. Cicero breaks down what the study revealed across more than 150 simulations in three states. Dr. Dorsett shares how the findings challenged her own assumptions as an educator and led to reflections on curriculum design, quality improvement, and the need for deliberate, high-frequency pediatric practice. Featured Article Quality of Care and Opportunities for Improvement in Prehospital Care of Critically Ill Pediatric Patients, An Observational, Simulation-Based Study

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Observational vs. Revelational Wisdom

Sermons – Wichita Falls Baptist Church

Play Episode Listen Later Aug 10, 2025 41:36

Is wisdom a burden or a blessing? Does it help us to understand and live life or is the pursuit of wisdom a burden to our souls? Solomon shows us that to truly lead a wise life we must not be wise in our own eyes, but rather fear God and turn from evil. Pastor Mollenkopf opens up Ecclesiastes to the saints today.

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Ep318: Modern Mindfulness - Victor Shiryaev

Guru Viking Podcast

Play Episode Listen Later Aug 1, 2025 146:53

In this episode I am joined by Victor Shiryaev a teacher of Buddhist and modern meditation and somatic practices. Victor recounts his childhood in the Soviet Union, early underground exposure to the New Age, and subsequent study of Avaita Vedānta and Ken Wilber's Integral Theory. Victor details his discipleship under American mindfulness teacher Shinzen Young, reflects on the tension between tradition and innovation, and shares stories of his own awakening experiences. Victor also lays out his disagreements with Shinzen Young's approach, critiques the Pragmatic Dharma's use of maps and stages, and presents his own understanding of the spiritual experiences to be expected on the road to awakening and beyond. … Video version: https://www.guruviking.com/podcast/ep318-modern-mindfulness-victor-shiryaev Also available on Youtube, iTunes, & Spotify – search ‘Guru Viking Podcast'.  … Topics include: 00:00 - Intro 00:56 - Childhood in the Soviet Union 02:24 - Exposure to the New Age and psychotherapy 07:15 - Studying Chinese History at university 08:07 - Advaita Vedānta and Ken Wilber 09:18 - Unity experience 10:21 - Altered states and psychic phenomena 13:14 - Personal crisis 14:52 - Awakening in Myanmar 17:19 - “I know what I have is working” 19:17 - Meeting Shinzen Young and adopting his model 24:50 - Observational statistics 27:29 - Studying with Shinzen 29:27 - Divorce and launching meditation teaching career 31:00 - Finding a path thru crisis 37:10 - Writing a letter to nature 42:48 - Finding purpose in spirituality 44:15 - Victor's teaching approach and activities 48:58 - Why go deeper in practice? 51:17 - Creating a culture of openness 58:33 - Shinzen & Ken Wilber vs Victor 01:05:16 - Being a clear conduit 01:19:32 - I am not a Buddhist teacher 01:12:40 - Experience vs faith 01:15:58 - Disagreements with Shinzen 01:17:43 - Disagreements with Theravāda 01:19:32 - Shinzen's modernism and scientism 01:25:19 - Steve's understanding of Shinzen 01:28:15 - Victor's update on Shinzen's scientism 01:30:50 - Heretics and reformers 01:33:39 - Fundamentalism and the world-centred view 01:30:39 - A world-centred view is also fundamentalist 01:42:50 - Victor on the Pragmatic Dharma movement 01:46:55 - Hypocrisy of Pragmatic Dharma 01:49:29 - Traditional vs modern practitioners 01:58:13 - Critique of maps and stages 02:06:18 - First stage: thoughts to presence 02:09:41 - Second stage: all experience is consciousness 02:12:09 - One taste 02:13:38 - Intimacy with all things 02:15:26 - The consciousness trap 02:18:18 - We shape our experience 02:19:10 - The pregnant void 02:22:32 - Victor's view of the path To find out more about Victor Shiryaev, visit: - https://victorshiryaev.co/ … For more interviews, videos, and more visit: - www.guruviking.com Music ‘Deva Dasi' by Steve James

Mind the Gaps: What Simulation Reveals About Pediatric Readiness in EMS

The EMS Educator

Play Episode Listen Later Aug 1, 2025 50:27

How well do EMS teams manage critically ill pediatric patients—and how do we know? In this episode of the EMS Educator Podcast, hosts Rob Lawrence and Maia Dorsett speak with Mark Cicero, lead author of a landmark study published in Prehospital Emergency Care. The study used simulation to assess EMS performance in pediatric emergencies. From medication dosing errors to missed fundamentals like cap refill checks, Dr. Cicero breaks down what the study revealed across more than 150 simulations in three states. Dr. Dorsett shares how the findings challenged her own assumptions as an educator and led to reflections on curriculum design, quality improvement, and the need for deliberate, high-frequency pediatric practice. They also explore the power of SIM Box—a free, low-tech, high-impact simulation toolkit—and how small, creative learning opportunities can help EMS clinicians gain confidence, accuracy, and readiness for rare but high-stakes pediatric calls. Whether you're a field provider, educator, or medical director, this episode offers practical insights and real tools to help build a system of pediatric care that's proactive, not reactive. Ginger Locke highlights the episode's key points with her "Mindset Minute." Mentioned in the episode: Simbox: https://www.emergencysimbox.com/emstelesimbox Quality of Care and Opportunities for Improvement in Prehospital Care of Critically Ill Pediatric Patients, An Observational, Simulation-Based Study: https://www.tandfonline.com/doi/full/10.1080/10903127.2025.2500715 The EMS Educator is published on the first Friday of every month! Be sure to turn on your notifications so you can listen as soon as the episode drops, and like/follow us on your favorite platform. Check out the Prodigy EMS Bounty Program! Earn $1000 for your best talks! Get your CE at www.prodigyems.com. Follow @ProdigyEMS on FB, YouTube, TikTok & IG.

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Earth's deepest ecosystem discovered six miles below the sea

Nature Podcast

Play Episode Listen Later Jul 30, 2025 33:03

00:45 The deepest ecosystem ever discoveredResearchers have dived down to more than 9,000 metres below the surface of the Pacific and discovered surprisingly complex communities of life living in deep ocean trenches. The new research shows an array of animal life that appears to be using methane as a source of energy. The researchers are planning more dives to learn more about this mysterious ecosystem and how these animals can thrive despite the extreme pressure they face.Research Article: Peng et al09:36 Research HighlightsA fossilized leg bone reveals an 11-million-year-old fight between a terror bird and a caiman, plus the anti-ageing secret of ‘immortal' stars.Research Highlight: Rumble in the Miocene: terror bird versus caimanResearch Highlight: ‘Immortal' stars have an elixir of youth: dark matter11:45 How infections could awaken dormant cancerNew research reveals that infection by a respiratory virus has the potential to awaken dormant cancer cells. In mice studies, a team showed that inflammation caused by infection with influenza or SARS-CoV-2 could initiate the awakening of breast cancer cells that had metastasized to the lungs. Observational studies using human health data also showed that a COVID-19 infection was associated with increased risk of lung metastasis and cancer death. While the precise mechanisms are unknown, the team say that understanding the process could help mitigate any risks of cancer progression caused by a viral infection.Research Article: Chia et al.News and Views: Inflammation during viral infection can rouse dormant cancer cells21:45 Will physicists ever agree on quantum mechanics?A survey of more than 1,100 physicists has revealed that there are widely different interpretations of what quantum mechanics means for our understanding or reality. Reporter Lizzie Gibney takes us through the different ideas physicists have and asks if such disagreements even matter.Nature: Physicists disagree wildly on what quantum mechanics says about reality, Nature survey showsSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

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258 Duncan Harrison, Managing Director, JAC International

Japan's Top Business Interviews Podcast By Dale Carnegie Training Tokyo, Japan

Play Episode Listen Later Jul 25, 2025 46:01

“In Japan, if you want performance, you need ultra-clear expectations—people need to know the goal.” “Building trust means creating a safe environment where it's okay to make mistakes.” “Consensus-building is not optional in Japan—it's how decisions gain traction.” “Every new joiner has lunch with me and a one-on-one at three months—connection matters.” “Leading is about inspiring, guiding, and empowering people toward a common purpose.” Previously Duncan was Executive Director-Head of Asia Hamlyn Willams; Country Manager, Robert Walters, Korea; Associate Director, Commerce Finance, Robert Walters Japan; Sales Consultant deVere and Partners. He has a BA from the University of East Anglia. Duncan leads with a style that emphasizes clarity, collaboration, and cultural sensitivity, shaped by years of cross-cultural experience. His leadership approach in Japan is grounded in providing clear expectations and maintaining transparency. He recognizes that Japanese team members particularly value knowing exactly what success looks like, so he places a premium on setting ultra-clear goals and regularly celebrating achievements. Monthly gatherings that spotlight individual and team successes help reinforce collective motivation and performance. He builds trust by being approachable and relational. Every new hire is welcomed with a personal lunch on their first day, and after three months, each has a one-on-one coffee chat with him to reflect on their experience. Even in a 60-person organization, he maintains these touchpoints to foster an open culture and reinforce that leadership is accessible. Duncan also leads training sessions himself, using these opportunities to share personal stories of past challenges, signaling humility and building rapport. Understanding Japan's consensus-driven culture, Duncan avoids top-down decision-making. Instead, he practices “nemawashi,” engaging associate directors, managers, and often broader teams before implementing changes. This ensures decisions are well-received and supported. He contrasts this approach with his leadership experiences in China, where decisions were expected to come unilaterally from the top, and Korea, which he found to be more individually driven. Encouraging innovation and open communication is another hallmark of Duncan's leadership. To surface ideas, he established anonymous suggestion boxes and encourages feedback during regular check-ins. He emphasizes psychological safety, particularly when discussing mistakes or failed innovations. Creating an environment where it's safe to fail is, in his view, essential to fostering creativity and long-term growth. He also sees training as a core responsibility. New employees follow a structured two-month onboarding program, led by a combination of managers, HR, and himself. Observational learning is built in, with new staff shadowing client and candidate meetings across teams. His goal is not only skill-building but also early immersion into the company's values and standards. Duncan is deeply attuned to cultural and demographic shifts. He's pragmatic about Japan's aging and shrinking workforce and the limited pool of bilingual professionals. Rather than resist these constraints, he adapts by hiring internationally minded Japanese staff and experienced recruiters from other firms, and by setting realistic expectations for new leaders entering the Japanese market. His definition of leadership centers on inspiring, guiding, and empowering people toward a shared goal. He believes that leaders must earn trust and encourage followership—not through command, but through empathy, clarity, and inclusion. For foreign leaders new to Japan, his advice is to avoid trying to impose outside systems without first understanding the local context, to invest time in building trust and communication channels, and to respect the nuance behind why things are done a certain way. In Duncan's experience, leading in Japan requires humility, patience, and a commitment to listen before acting.

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Exploring "Observational Ecology" with Alan Ruiz Berman

Arizona Spotlight

Play Episode Listen Later Jul 17, 2025 31:24

Also on Arizona Spotlight: Local grassroots theater group debuts a new comedy/mystery; and how a local middle school teacher reclaimed her life after a tragic illness.

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Exploring "Observational Ecology" with Alan Ruiz Berman

Arizona Spotlight

Play Episode Listen Later Jul 17, 2025 31:24

Also on Arizona Spotlight: Local grassroots theater group debuts a new comedy/mystery; and how a local middle school teacher reclaimed her life after a tragic illness.

ruiz ecology berman observational

How Animals Medicate with Dr. Jaap De Roode

BIOACTIVE with Riley Kirk

Play Episode Listen Later Jul 11, 2025 59:39

In this conversation, host Dr. Riley Kirk and guest Dr. Jaap De Roode discuss the fascinating field of zoo pharmacognosy, exploring how animals medicate themselves using natural substances. He shares insights from his research on monarch butterflies and honeybees, highlighting the role of toxic compounds and fungi in animal health. The discussion also touches on the implications for agriculture, the importance of biodiversity, and the potential for learning from animal behaviors in medicine. Dr. De Roode emphasizes the need for more research in this area and the significance of maintaining natural ecosystems for the health of both animals and humans. Key Takeaways Zoo pharmacognosy is the study of how animals medicate themselves. Monarch butterflies use toxic milkweed compounds to combat parasites. Honeybees may use fungi to treat infections in their colonies. Animal medication can be a learned behavior or instinctual response. Diversity in diet is crucial for animal health and resilience. Propolis serves as both a cement and a medicinal substance for bees. Observational studies provide insights into animal medication behaviors. Animals can change their behavior based on their health needs. Research on animal medication can inform agricultural practices. Understanding animal medication can lead to new discoveries in human medicine. Chapters 00:00 Introduction to Zoo Pharmacognosy 04:08 Research Focus: Monarch Butterflies and Honeybees 10:58 Defining Animal Medication vs. Self-Medication 14:59 Examples of Animal Medication in Nature 18:20 Chimpanzees and Traditional Healing 24:38 Learning and Sharing Medicinal Knowledge in Animals 26:14 The Fascinating World of Animal Self-Medication 28:53 Agricultural Practices and Animal Health 32:38 The Importance of Choice and Diversity in Animal Diets 33:37 Studying Animal Behavior and Medicating Practices 35:56 Recreational Use of Plants by Animals 40:56 Addressing Animal Anxiety and Depression 43:52 Natural Products in Animal Medicating 46:21 Evolution of Medicating Behaviors in Animals 48:21 Cannabis and Animal Self-Medication 51:31 Researching Fungi and Bees 55:20 Insights from 'Doctors by Nature' Thank you to our sponsor for this episode GAVITA: For over 40 years, Gavita has been the trusted name in horticultural lighting, setting the benchmark for performance, reliability, and innovation. https://gavita.com/category/led-grow-lights/ IG: @gavitanorthamerica Follow Dr. De Roode's research: https://biology.emory.edu/people/bios/faculty/de-roode-jaap.html Follow Dr. De Roode on IG and LinkedIn IG @jaapderoode LI: https://www.linkedin.com/in/jaap-de-roode-04a6a6237/ Read or listen to Doctors by Nature https://www.amazon.com/Doctors-Nature-Other-Animals-Themselves/dp/069123924X Check out my book Reefer Wellness! ⁠⁠⁠https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156⁠⁠⁠ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠

Isaiah 44: Observational Outline

Play Episode Listen Later Jul 6, 2025 55:01

We build an observational outline of Isaiah 44

Isaiah 44: Observational Outline

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Play Episode Listen Later Jul 6, 2025 55:00

The sermon explores the theological complexities of obedience to God's commandments and the role of scripture, ultimately questioning the effectiveness of contemporary church practices. It examines the futility of idolatry and human attempts to understand the divine, contrasting human efforts with God's sovereignty and purpose. Through an observational outline of Isaiah 44, the message highlights God's unique identity as Creator and Redeemer, emphasizing His promise of restoration and the use of unexpected instruments, like Cyrus, to fulfill His will, while challenging the tendency to impose human-centric interpretations onto biblical texts.

Does the Bible Teach a Flat Earth?

Answers with Ken Ham

Play Episode Listen Later Jun 24, 2025

Observational science confirms that the earth is a sphere. Science always confirms God's Word.

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Shortcast: Sleep quality in children with hepatic GSDs, a prospective observational pilot study

JIMD Podcasts

Play Episode Listen Later May 27, 2025 8:38

Lucas Agnoletto and Dr Rebecca Halligan report work looking at sleep quality in children with hepatic GSDs, considering whether sleep is impacted by poor glycemic control or our efforts to improve this through overnight feeding. Sleep quality in children with hepatic glycogen storage diseases, a prospective observational pilot study Lucas Agnoletto, et al https://doi.org/10.1002/jmd2.12462

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Isaiah 43: Observational Outline Pt 1

bible theology bible study outline isaiah 43 observational

Play Episode Listen Later May 25, 2025 62:32

In this episode, we return to our long-form study through Isaiah 40–55 by walking slowly and carefully through an observational outline of Isaiah 43. Rather than rushing to application or theological conclusions, we seek to see what is actually in the text.

CHRONIC RETINAL DETACHMENT Surgical vs. Observational Approach With Optical Coherence Tomography Monitoring

RETINA Journal Podcasts

Play Episode Listen Later Mar 31, 2025 6:55

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Richard Gere and Paul Schrader reunite; Looney Tunes hits us with nostalgia; and an observational doco for cat lovers

RRR FM: Plato's Cave

Play Episode Listen Later Mar 31, 2025 43:48

This week we reviewed three films that all opened in Australian cinemas last week, but otherwise have little else in common.Our guest host Thomas Caldwell was joined by Silvi Vann-Wall and Vyshnavee Wijekumar. They discuss Richard Gere's reunion with American Gigolo writer and director Paul Schrader in Oh, Canada (also starring Uma Thurman and Jacob Elordi); the first fully animated Looney Tunes feature film, The Day the Earth Blew Up: A Looney Tunes Movie, showcasing magnificent craftsmanship in its 2D animation and hitting the nostalgic feels; and Kazuhiro Soda's observationist documentary The Cats of Gokogu Shrine, which reveals a community collectively caring for stray cats.

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Isaiah 42: Observational Outline Pt 2

Play Episode Listen Later Mar 30, 2025 69:23

We conclude the observational outline of Isaiah 42

Isaiah 42: Observational Outline Pt 1

bible bible study outline observational

Play Episode Listen Later Mar 30, 2025 53:41

We begin our work of building an observational outline for Isaiah 42

Isaiah 42: Observational Outline Pt 1

Play Episode Listen Later Mar 30, 2025 53:40

We begin our work of building an observational outline of Isaiah 42

Isaiah 42: Observational Outline Pt 2

Play Episode Listen Later Mar 30, 2025 69:22

We conclude the observational outline of Isaiah 42

Voices of VR Podcast – Designing for Virtual Reality

#1545: “Shelter” Observational 360 Documentary Shows Intimate Side of War via Ukrainian Citizen Bomb Shelters

Play Episode Listen Later Mar 29, 2025 39:36

SHELTER is a 360 video documentary telling the story of civilians in Ukraine seeking protection in bomb shelters. The film poetically transports you the many different ways Ukrainians are sheltering from small cramped basements to parking garages to hospitals. It also contrasts these underground spaces to the aftermath of war from bombed out buildings to funerals for Ukrainian soldiers. The experience always documents how the dream lives of Ukrainians are impacted by the war as they also overlay these dream sequences over billboarded videos of drone strikes. Overall, it's a meditative and powerful journey of cinéma vérité, observational durational takes that are juxtaposed together to tell a much larger story of the human impact of war. . Check out my deep dive with director Sjors Swierstra and producer Justin Karten for more insights in how they put this piece together. Apple's push for 180-degree immersive video has brought up some broader discussions about the merits and downsides to 360-degree films. From a creator's point of view, 180-degree filmmaking is a lot easier to do logistically as it is closer to existing production pipelines, which is brilliantly demonstrated in CURRENTS. The main downside is that it is difficult to control where people are looking, but the main benefit is that you're able to preserve the full context of a place. SHELTER was one of two films that really leaned into being able to be fully transported to a place without having to worry about selecting a constrained frame or point of focus. This is a listener-supported podcast through the Voices of VR Patreon. Music: Fatality

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The Robotics Revolution, with Physical Intelligence's Cofounder Chelsea Finn

No Priors: Artificial Intelligence | Machine Learning | Technology | Startups

Play Episode Listen Later Mar 20, 2025 35:14

This week on No Priors, Elad speaks with Chelsea Finn, cofounder of Physical Intelligence and currently Associate Professor at Stanford, leading the Intelligence through Learning and Interaction Lab. They dive into how robots learn, the challenges of training AI models for the physical world, and the importance of diverse data in reaching generalizable intelligence. Chelsea explains the evolving landscape of open-source vs. closed-source robotics and where AI models are likely to have the biggest impact first. They also compare the development of robotics to self-driving cars, explore the future of humanoid and non-humanoid robots, and discuss what's still missing for AI to function effectively in the real world. If you're curious about the next phase of AI beyond the digital space, this episode is a must-listen. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @ChelseaFinn Show Notes: 0:00 Introduction 0:31 Chelsea's background in robotics 3:10 Physical Intelligence 5:13 Defining their approach and model architecture 7:39 Reaching generalizability and diversifying robot data 9:46 Open source vs. closed source 12:32 Where will PI's models integrate first? 14:34 Humanoid as a form factor 16:28 Embodied intelligence 17:36 Key turning points in robotics progress 20:05 Hierarchical interactive robot and decision-making 22:21 Choosing data inputs 26:25 Self driving vs robotics market 28:37 Advice to robotics founders 29:24 Observational data and data generation 31:57 Future robotic forms

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MPL Live Boston: Engagement scores don't tell the full story (CPOs of DraftKings, Klaviyo, and Smartcat)

The Modern People Leader

Play Episode Listen Later Mar 14, 2025 106:38

Linda Aiello (CPO, DraftKings), Carmel Galvin (CPO, Klaviyo), and Stacey Richey (Global VP, People, Smartcat), joined us for MPL Live in Boston, Massachusetts.We talked about the current state of HR, how roles are shifting with AI, and how they're moving beyond traditional engagement metrics.----

Patrick Tarnowski: Analyzing Gait, The Sixth Vital Sign

Healthy Wealthy & Smart

Play Episode Listen Later Mar 13, 2025 43:35

In this Healthy, Wealthy, and Smart Podcast episode, host Dr. Karen Litzy welcomes Patrick Tarnowski, PT, MBA, a physical therapist and chief commercial officer at One Step, to discuss the gait analysis. Gait analysis is the study of how we walk, a crucial area of focus for physical therapists, especially regarding aging and overall health. Pat shares his extensive background in healthcare, spanning over two decades, and describes his journey from patient care to leading innovations in gait analysis and patient outcomes. Listeners will gain insights into the importance of gait analysis, how it changes with age, and what it means for improving health and mobility. Please tune in to learn more about this vital aspect of physical therapy and its impact on patient care. Time Stamps: [00:01:51] Gait analysis and biomechanics. [00:07:28] Gait analysis essentials. [00:08:35] Observational gait analysis effectiveness. [00:12:38] Correlating patient goals with analysis. [00:18:01] Functional assessment in treatment plans. [00:22:39] Patient confidence and gait analysis. [00:24:56] Gait speed as vital sign. [00:31:15] Gait analysis using smartphones. [00:34:40] Monitoring patients in real world. [00:38:45] Importance of mobility in health. More About Patrick Tarnowski, PT, MBA: As Chief Commercial Officer at OneStep, Pat is accountable for the company's US market entry through strategic provider partnerships. His deep healthcare experience as a leader in health plans, health systems, medical devices, startups and digital care delivery support and enable OneStep's growth and scale. As an entrepreneur, Pat has successfully launched and scaled care delivery companies, digital solutions that focused on health and wellbeing, disease management and virtual care and worked with providers to achieve success in value-based payment models. He received his degree in physical therapy from Boston University and his master's in business administration from the University of St. Thomas. A lifelong learner, Pat has also held several academic appointments and is a grant reviewer for the National Science Foundation's SBIR seed fund and served as an Industry Mentor for their I-Corp Innovation program. He has been the principal investigator in numerous clinical studies and is the Vice President of Professional Practice of the Minnesota Chapter of the American Physical Therapy Association's and the Minnesota Cancer Alliance Steering Committee. Pat lives in Minneapolis with his family, dog Maizey and is a committed outdoors enthusiast and endurance athlete. Resources from this Episode: One Step Website Pat on LinkedIn Jane Sponsorship Information: Book a one-on-one demo here Front Desk @ Jane Mention the code LITZY1MO for a free month Follow Dr. Karen Litzy on Social Media: Karen's Twitter Karen's Instagram Karen's LinkedIn Subscribe to Healthy, Wealthy & Smart: YouTube Website Apple Podcast Spotify SoundCloud Stitcher iHeart Radio

Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies

American Journal of Gastroenterology - Author Podcasts

Play Episode Listen Later Mar 3, 2025 11:39

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Observational Outline: Isaiah 41