Podcasts about observational

A headline like “weight loss drugs may reduce breast cancer risk” grabs attention fast, but the real story lives in the fine print. We take you through a new Penn Medicine study that observed lower breast cancer rates among women with overweight or obesity who used GLP-1 medications, then we translate what that finding actually means in plain language. Observational data can reveal a signal worth studying, but it cannot prove the medication caused the outcome, and that distinction matters for your decisions and your expectations. We also zoom out to the bigger why: obesity is not just about body size. Fat tissue is biologically active, shaping chronic inflammation, estrogen exposure after menopause, insulin resistance, and even how well the immune system spots abnormal cells. Those pathways help explain why obesity is linked to many cancers, including postmenopausal breast cancer, and why researchers are curious whether effective obesity treatment could shift risk over time. Then we get practical. We review what stronger evidence from randomized controlled trials says so far: GLP-1 drugs like Ozempic, Wegovy, Mounjaro, and Zepbound do not appear to increase breast cancer risk in the available trial data, even though most trials were not designed to study cancer outcomes for many years. We also discuss why newer studies seem most suggestive for hormone receptor positive breast cancer, along with the leading theories: weight loss itself, improved metabolic health and insulin signaling, reduced inflammation, and the still-unclear possibility of direct GLP-1 effects in cancer biology. If you like evidence-based medicine with real-world context (and a little Philly-life banter), subscribe, share this episode with a friend, and leave a review so more people can find the show. What question do you want answered next about GLP-1s, obesity treatment, or cancer risk?ReferencesRisk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists : A Systematic Review and Meta-Analysis. Ko A, Chang YC, Bahar F, et al. Annals of Internal Medicine. 2025;. doi:10.7326/ANNALS-25-02237.Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-Analysis. Piccoli GF, Mesquita LA, Stein C, et al. The Journal of Clinical Endocrinology and Metabolism. 2021;106(3):912-921. doi:10.1210/clinem/dgaa891.Glucagon-Like Peptide 1 Receptor Agonists and Cancer Risk: The Good, the Bad and the Unknown. Mannucci E, Dicembrini I. Nature Reviews. Clinical Oncology. 2026;23(6):459-470. doi:10.1038/s41571-026-01135-0.GLP-1 Agonists Are Associated With a Significant Reduction in Breast Cancer Incidence in Women. McDonald ES, Gillis LB, Gabriel P, et al. JCO Oncology Practice. 2026;:101200OP2600485. doi:10.1200/OP-26-00485.GLP-1 therapy and hormone receptor–positive breast cancer risk and survival: A real-world analysis.. Shah Z, Hundal J, Afridi S, et al. Journal of Clinical Oncology. 2026;44(Suppl 16):10548. doi:10.1200/JCO.2026.44.16_suppl.10548.Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer. Tatum KL, Dahman B, Stevenson A, et al. JAMA Network Open. 2026;9(5):e2612133. doi:10.1001/jamanetworkopen.2026.12133.Association of Glucagon-Like Peptide-1 Receptor Agonists With Risk of Cancers-Evidence From a Drug Target Mendelian Randomization and Clinical Trials. Sun Y, Liu Y, Dian Y, et al. International Journal of Surgery (London, England). 2024;110(8):4688-4694. doi:10.1097/JS9.0000000000001514.GLP-1 receptor agonists and breast cancer risk in type 2 diabetes.. Guo Cheng and Amanda Ward. Journal of Clinical Oncology. 2025;43(Suppl 16):10557. doi:10.1200/JCO.2025.43.16_suppl.10557.Glucagon-Like Peptide-1 Analogues and Risk of Breast Cancer in Women With Type 2 Diabetes: Population Based Cohort Study Using the UK Clinical Practice Research Datalink. Hicks BM, Yin H, Yu OH, et al. BMJ (Clinical Research Ed.). 2016;355:i5340. doi:10.1136/bmj.i5340.GLP-1 Receptor Agonists and Cancer: Current Clinical Evidence and Translational Opportunities for Preclinical Research. Valencia-Rincón E, Rai R, Chandra V, Wellberg EA. The Journal of Clinical Investigation. 2025;135(21):e194743. doi:10.1172/JCI194743.Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.Support the showProduction and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RNArtwork Rebrand and Avatars:Vantage Design Works (Vanessa Jones) Website: https://www.vantagedesignworks.com/Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qrOriginal Artwork Concept: Olivia Pawlowski

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton and John look back at Week 13 in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

For far too long, many women have been told their symptoms were normal, exaggerated, or simply something they had to live with—treated as isolated problems instead of part of a much larger hormonal transition happening inside the body. On this episode of The Dr. Hyman Show, I'm joined by Dr. Sharon Malone, host of The Second Opinion podcast and Chief Medical Advisor at Alloy Women's Health. We discuss how menopause and hormone therapy became so misunderstood, the real story behind the Women's Health Initiative study, and why a more individualized, prevention-focused approach to women's health is long overdue. Watch the full conversation on YouTube, or listen wherever you get your podcasts. We explore: Why so many women enter perimenopause completely unprepared—and how symptoms can begin years before menopause officially starts What the Women's Health Initiative actually found, and how one medical narrative reshaped women's healthcare for decades How menopause affects far more than reproduction, including the brain, heart, sleep, metabolism, and bone health What you should know about hormone therapy today, including timing, individualized treatment, and understanding risk in context The daily habits that still matter most for healthy aging, whether or not you choose hormone therapy Midlife health should never be reduced to “just deal with it.” The more women understand what's happening inside their bodies, the earlier they can take steps to protect their long-term health and quality of life. View Show Notes From This Episode Sign up for Dr. Hyman's Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health - ⁠Click Here⁠ Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Paleovalley, Pique, Perfect Amino, Rho, Sunlighten and BIOptimizers. Head to paleovalley.com/hyman to save 15% off your first order today. Secure 20% off your order plus a free starter kit at piquelife.com/hyman. Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order. Head over to rhonutrition.com and use code HYMAN to get 20% off their entire product line. Visit sunlighten.com and use code HYMAN to save up to $1600 today! Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. (0:00) Introduction, survey on hormone use, and Dr. Sharon Malone's expertise   (4:04) Importance of women's health research and historical neglect   (5:35) Lack of education and preparation for menopause   (6:28) Societal and historical biases in women's health   (9:05) Observational studies vs. randomized controlled trials   (13:30) Life cycles, hormonal changes, and stages in women   (19:26) Detailed stages of hormonal changes and perimenopause   (23:00) Misdiagnosis and definition of menopause   (25:02) The term "postmenopausal" and its significance   (26:34) Impact of menopause on organ systems and major symptoms   (31:19) Lifestyle factors and hormone therapy options   (39:25) Black box warning, Women's Health Initiative, and therapy timing   (45:00) Women's Health Initiative findings and breast cancer risk   (47:57) Reinterpreting breast cancer risk and black box warning   (53:21) Personalized hormone therapy and clinical diagnosis   (59:55) Importance of estrogen and bioidentical vs. synthetic hormones   (1:03:35) Addressing sexual health and testosterone use for women   (1:08:05) FDA-approved peptides for women's arousal disorder   (1:09:57) Long-term benefits of hormone therapy   (1:12:43) Early menopause, hormone therapy, and health impacts   (1:15:07) Estrogen's role in brain health and dementia prevention   (1:16:22) Alzheimer's risk in women and hormonal 

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton and John look back at Week 12 in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Alzheimer's disease is expected to affect nearly 78 million people worldwide by 2030, making research into supportive lifestyle and dietary factors more urgent than ever Bottlenose dolphins develop the same brain changes seen in Alzheimer's patients, giving researchers a new way to study how memory loss unfolds Research associates a fat called C15:0, found in full-fat dairy and pasture-raised meats, with lower inflammation markers and stabilized neurotransmitter signaling related to memory and mood Observational studies have linked higher C15:0 levels with lower rates of diabetes, liver disease, and cardiovascular conditions that share metabolic pathways with brain aging Replacing seed oils with traditional saturated fats, increasing dietary C15:0 from full-fat dairy and pasture-raised meats, and discussing C15:0 supplementation with a qualified health care provider may form part of a broader strategy for supporting brain and metabolic health as you age

Sponsor Link:Secure your online life...make sure your data stays yours alone. Do what we did and get NordVPN with our special deal which includes an extra 4 months for free and big savings, all at no risk to you. To check out the details visit www.nordvpn.com/spacenutsComets, Meteors, and Celestial Wonders In this engaging episode of Space Nuts, hosts Andrew Dunkley and Professor Jonti Horner dive deep into the fascinating world of comets and meteors. With Professor Fred Watson away, Jonti brings his expertise to explore these celestial phenomena, their historical significance, and the science behind them.Episode Highlights:- Understanding Comets and Meteors: Andrew and Jonti kick off the episode by discussing the importance of comets and meteors in both ancient cultures and modern astronomy. They delve into how these celestial objects have been perceived throughout history and their impact on human events.- Recent Discoveries and Predictions: The hosts share insights on recent comet discoveries, including the intriguing Comet Chichin Chan, and discuss what we can expect from this comet in the near future. They also touch on the challenges of predicting comet brightness and visibility.- Meteor Showers Explained: Jonti explains how meteor showers occur, the significance of radiant points, and what conditions are best for viewing these spectacular events. They discuss the most notable meteor showers and when listeners can catch them in action.- The Impact of Media on Public Perception: The conversation takes a turn as Andrew and Jonti address the role of media in shaping public understanding of astronomical events, particularly the sensationalism surrounding potential alien encounters and the importance of relying on scientific facts.For more Space Nuts, including our continuously updating newsfeed and to listen to all our episodes, visit our website. Follow us on social media at SpaceNutsPod on Facebook, Instagram, and more. We love engaging with our community, so be sure to drop us a message or comment on your favourite platform.If you'd like to help support Space Nuts and join our growing family of insiders for commercial-free episodes and more, visit spacenutspodcast.com/about.Stay curious, keep looking up, and join us next time for more stellar insights and cosmic wonders. Until then, clear skies and happy stargazing.Become a supporter of this podcast: https://www.spreaker.com/podcast/space-nuts-astronomy-insights-cosmic-discoveries--2631155/support.

In this episode of In Demand, Asia and Kim dive into product management. They cover problem space versus solution space and why so many founders and product teams build features based on assumptions, customer requests, or competitive pressure without doing the discovery work necessary to understand what users are actually trying to accomplish. This episode is a masterclass on how to avoid building features nobody uses and how to create products that customers genuinely adopt, value, and pay for. Got a question you'd like Asia to unpack on the podcast? Record a voicemail here. Links:  DemandMaven Subscribe to The Work by DemandMaven on Substack The Lean Product Playbook by Dan Olsen Playing to Win: How Strategy Really Works  Continuous Discovery Habits by Theresa Torres Chapters (00:01:00) - Product discovery and idea validation.(00:03:15) - Why understanding the problem deeply creates better product decisions.(00:06:05) - What product discovery actually means in practice.(00:14:40) - Observational research and watching users interact with products.(00:16:15) - User stories versus hypothetical behavior.(00:19:50) - An example of the user stories you might look for on a SaaS reporting function.(00:23:45) - How support tickets can help lead you to the areas you should start working on.(00:29:00) - Castos example: uncovering integration problems through user stories.(00:37:45) - Theresa Torres and the Continuous Discovery approach.(00:44:30) - How discovery creates clearer product strategy and positioning.

As I have said many times before, some podcast ideas come from REAL clinic encounters. In this episode, Dr Hanna V, our dedicated PGY1 on our call team, and I will answer TWO real questions which arose just today on morning rounds, on our service: 1. Does NORMOTENSIVE HELLP still need Mag Sulfate? And 2. Does an indwelling foley s/p iatrogenic bladder injury at CS require prophylactic antibiotic coverage for urinary infection? Yep: It's a BOGO sale on today's podcast- Buy ONE GET ONE! Listen in for details.1. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222.Obstetrics and Gynecology. 2020. Committee on Practice Bulletins—ObstetricsGuideline2. Woudstra DM, Chandra S, Hofmeyr GJ, Dowswell T.SR. Corticosteroids for HELLP (Hemolysis, Elevated Liver Enzymes, Low Platelets) Syndrome in Pregnancy.The Cochrane Database of Systematic Reviews. 2010. 3. Joshi D, James A, Quaglia A, Westbrook RH, Heneghan MA.Liver Disease in Pregnancy. Lancet. 2010. Review4. Rimaitis K, Grauslyte L, Zavackiene A, et al.Observational. Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre. International Journal of Environmental Research and Public Health. 20195. Reau N, Munoz SJ, Schiano T.Guideline Liver Disease During Pregnancy.The American Journal of Gastroenterology. 2022. 6. ACG Clinical Guideline: Liver Disease and Pregnancy.The American Journal of Gastroenterology. 2016. Tran TT, Ahn J, Reau NS.7. ACOG Practice Bulletin No. 195: Prevention of Infection After Gynecologic Procedures. Obstetrics and Gynecology. 2018. Committee on Practice Bulletins—Gynecology Guideline8. Niels Johnsen, Hunter Wessells, Krystal Archer-Arroyo, et al. Best Practices Guidelines Management of Gentiunrinary Injuries.American College of Surgeons (2025). 20259. Fletke KJ, Jeong DH, Herrera AV . Urinary Catheter Management. American Family Physician. 2024..

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton and Ryan look back at Week Two in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton and Ryan look back at Week Two in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Recorded: Tuesday, May 5th, 2026Location: Melbourne, AustraliaSponsor: Notes RunningA Note To The Runners: Get my book here.Register for my mentorship! ⁠Fill it out the form here.Buy me a coffee: My order is a long black.Poem:We think that once our day begins,we must race to the end,beating the sun to the floorboards,finishing our coffeebefore it's cold, and lifelesscatching the leaves before they hit the ground,These are the races of life not to be won. To finish, 4th, 3rd, first, for what?To get the end before someone else?

On this episode of Drinking from the Gardenhose, OB and ED break down the science behind their perfectly unscientific season structure (yep—26 episodes and out) before diving headfirst into a generational showdown. From gym floors to volleyball tournaments, the guys unpack the timeless mystery of zero spatial awareness—teenagers blocking everything, phones everywhere, and the uncomfortable realization that… yeah, they probably did the same thing back in the day. Along the way, they debate etiquette, social media habits, and what it really means to be "that guy" in public spaces. Plus, OB drops a classic story from a charity sword-fighting event at the Franklin Institute that somehow turns into an accidental first-date moment you won't see coming. Observational, relatable, and just the right amount of chaotic—tap in and drink from the hose.

Join AI host Griffin Rowe as the James Webb Space Telescope unveils the universe's earliest galaxy, MoM z14, existing just 280 million years after the Big Bang. We explore chaotic young galaxies, examine potential biosignatures on exoplanet K2-18b, investigate how galaxy shapes reveal dark matter's nature, and witness Webb's groundbreaking direct imaging of a Saturn-mass planet around TWA 7.Loved this episode? Discover more original shows from the Quiet Please Network at QuietPlease.ai, explore our curated favorites here amzn.to/42YoQGI, and catch just a slice of our AI hosts in action on Instagram at instagram.com/claredelish and YouTube at youtube.com/@DIYHOMEGARDENTVThis content was created in partnership and with the help of Artificial Intelligence AIThis episode includes AI-generated content.

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton, John and Ryan look back at Week Two in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Welcome to Ozempic Weightloss Unlocked, where we dive into the latest news on Ozempic, from medical breakthroughs to lifestyle impacts.Novo Nordisk, the maker of Ozempic and Wegovy, just announced a strategic partnership with OpenAI. Daily Sabah reports this collaboration will use artificial intelligence to speed up new medication development and deliver better treatments faster. OpenAI CEO Sam Altman says it will accelerate scientific discovery and redefine patient care, with full integration by the end of 2026.In other big news, Apotex received the first United States Food and Drug Administration tentative approval for a generic version of Ozempic, semaglutide injection. PR Newswire and Apotex announcements highlight this milestone, developed with Orbicular, which could broaden access to affordable options once patents expire. Pearce IP Law notes it positions Apotex to launch early, following generics in India from companies like Dr Reddys and Sun Pharma.Novo Nordisk also launched a higher dose Wegovy HD at 7.2 milligrams for weight loss, approved under a priority program and now available in the United States.A new study in Genome Medicine, reported by Stanford Medicine and Science Daily, explains why Ozempic does not work for everyone. About one in ten people have genetic variants causing GLP-1 resistance, where their bodies produce more of the hormone but respond poorly, especially for blood sugar control. Lead researcher Anna Gloyn notes these variants reduce effectiveness after months of treatment. It is unclear yet if this affects weight loss at higher doses.University of Washington endocrinologist David Cummings praises GLP-1 drugs like Ozempic for strong evidence in weight reduction, diabetes control, heart and kidney protection, arthritis relief, and sleep apnea improvement. Observational data suggests benefits against obesity-related cancers, substance abuse, and possibly dementia.As supply stabilizes post-shortage, compounded semaglutide remains available through certain pharmacies, but regulations tightened in 2026, per Injectco.These updates show Ozempic evolving, blending innovation with personalized health insights for better lifestyles.Thank you for tuning in, listeners. Please subscribe for more. This has been a Quiet Please production, for more check out quietplease.ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

Welcome back to the tasty morsels of critical care podcast. Today we look at blunt cerebrovascular injury or BCVI. I added this to my list to cover for unclear reasons as when i looked back at my notes i had about 8 bullet points and a couple of referenced articles. So this will be shorter than usual I suspect. Effectively this refers to injuries to the carotids and vertebral arteries in the context of trauma. The pathology here is typically a pinch, twist or stretch of the vessel leading to an intimal tear in the vessel. The exposed endothelium then is a nidus for thrombus formation. The main downstream consequence is stroke and it’s a real shame to have a successful haemostatic and surgical resus of a major trauma patient only to have them suffer a life changing stroke 3 days into their hospital stay. They’re also pretty tricksy injuries as there are rarely obvious clinical signs to indicate their presence until they you find the dense hemiplegia, so this is one of those things were the term “index of suspicion” comes into play. It is especially important seeing as we have now effectively outsourced all diagnosis to the radiologists and these injuries are not picked up on the typical trauma pan scan that we so love. Given that I described the pathology of the injury as pinching, twisting and stretching we can probably get a sense of the mechanism of injury associated with these injuries. Top of the list here are c-spine injuries – if the neck has moved enough to break it you should think about the delicate blood vessels beside the c-spine. This is particularly pertinent to the vertebrals whose course, evolution in her wisdom, placed inside the tiny little vertebral foramen transversarium of the c spine itself. To make life more difficult for the poor little vertebrals they have to navigate a few 90 degree turns to get between C1 and the skull to get into the foramen magnum. This is reflected in the higher incidence of BCVI in high spine injuries. Obvious other associations are with severity of TBI and complex facial fractures (remember the carotid has to navigate its way past these). You might get some pointers to diagnosis from your clinical exam. Horner’s syndrome would be a classic (disruption to sympathetic neurons in the carotid) but if you’re diagnosing a Horner’s syndrome in your primary survey then you’re either over achieving or doing it wrong or possibly both. They may have stroke features on arrival which would be an obvious trigger for imaging. A bruit is also listed as a sign of injury but I think that’s a sign for better clinicians than you or I. Most of the time you will have an injured patient without specific symptoms of BCVI. Who do we pursue further imaging on given that I’ve already noted the initial trauma pan scan will often not pick up this? Enter stage left the geographically titled criteria each named after the academic centre that developed it. Denver, Memphis and Boston have all contributed a published criteria. The Denver criteria appear to be the most commonly used and referenced. I think listing the individual components is probably beyond the scope of the post but I’d emphasise the main headlines c-spine injuries facial fractures complex base of skull severe TBIs hanging Once you’ve decided the patient needs imaging then you should be reaching for our trusty friend the CT scanner. in this case a well done CT angiogram of the neck vessels extending into the intracranial vessels. It is not (unsurprisingly) a perfect test but it is a very good test and certainly where you should start. If you do find a BCVI you may even have the joy of seeing it classified I to V according to the wonderfully named Biffl classification system. It covers things like intimal tears and degrees of narrowing and occlusion. once you’ve found a BCVI it’s unclear who your go to specialist might be and I have seen vascular, neurosurgery and stroke all give opinions on treatment. Overall risk of stroke in BCVI is ~8% but changes significantly depending on grade with higher grades having higher stroke risk. For the vast majority of patients your treatment options come down to heparin vs aspirin. There does not appear to be a clear proven superiority of one strategy over the other. Some form of antithrombotic does, in observational data, seem to reduce stroke rate and is probably worth doing. Aspirin is generally easier delivered and seems to be the most common choice in our region. Many of the injuries would actually be amenable to surgical repair but the vast majority are surgically inaccessible hence the antithrombotic treatment as next best thing. The decision to give something that makes clotting more difficult in a patient who is either still bleeding or at risk of major bleeding is not an easy one. Hence there is typically a day or two of hand wringing amongst several specialties till we are all comfortable giving it. Observational work suggests that we’re likely a little overcautious on this in a similar way to our reluctance to commence VTE prophylaxis in TBI. Reading Doctor’s Little Helper Radiopaedia

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton, John and Ryan look back at Week Two in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton and John look back at Week Two in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton, John and Ryan look back at Week Two in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton and John look back at Week Two in the USL Championship, playing show and tell with an exciting slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics.If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Part 1 of the LIVE Q&A session from January 2026.In the Zone is an in-depth question-and-answer session about a wide range of scriptural topics. Created in the image of Elohim and parents' expectations? Married couples becoming one flesh related to this? Why didn't Elohim create a “perfect world”? How do we ‘receive the love of Elohim'? This is a safe placeIs doing evil always a choice? All things are possible  Is this a blessing? Driving the lawlessness out of my heart? Confusification? Messiah's righteousness IMPUTED to us? Confusing the final judgment with the judicial system  Steadfast and faithful love Observational awareness Subscribe to be notified of new content each week.Learn more about MTOI:https://mtoi.orgThe MTOI App https://mtoi.org/download-the-mtoi-appFollow MTOI:https://www.facebook.com/mtoiworldwide https://www.instagram.com/mtoi_worldwidehttps://www.tiktok.com/@mtoi_worldwide Contact MTOI: 

Welcome back to This League!, our show covering the USL Championship's biggest stories, characters, and on-field action. Every week, the Backheeled crew runs the Championship's gauntlet to provide fresh observations from around the league. Peyton, John and Ryan look back at Week One in the USL Championship, playing show and tell with an exciting opening slate of gamesWant to watch this episode instead? Click here. You'll get to see smiling faces and neat graphics. If you enjoyed this episode, leave us a rating and subscribe to Backheeled.com for more American soccer coverage! Hosted on Acast. See acast.com/privacy for more information.

Episode 215: Meth-associated HFrEF.   Abishak and Zat (medical students) explain the cardiotoxic effect of methamphetamine and the diagnosis and treatment of heart failure with reduced ejection fraction (HFrEF). Dr. Arreaza adds insight into the reversibility of meth-associated HFrEF.   Written by Abishak Govindarajan, MSIV and Zat Akbar Shaw. American University of the Caribbean. Edits and comments by Hector Arreaza, MD. Welcome Dr. Arreaza: Welcome to Rio Bravo qWeek. My name is Hector Arreaza, family physician, faculty and associate program director of the Clinica Sierra Vista/Rio Bravo Family Medicine Residency Program. Today we will explore heart failure with reduced ejection fraction, a high-yield and clinically relevant topic in medicine. We will discuss the role of methamphetamine use in the development of HFrEF. This is a pressing issue because about 0.8% of the population 12 and older in the US reported using methamphetamine within the past 12 months in 2024 (National Survey on Drug Use and Health, NSDUH), that's about ≈2.4 million people!We are joined by two aspiring physicians who will help explore this topic. By the way, we will refer to methamphetamine in this episode as “meth”. [Abishak and Akbar introduce themselves] Abishak: [Introduce yourself] The role of meth in HFrEF Dr. Arreaza: Meth is a growing problem in many places, including Bakersfield, where we live. Meth is also known as Meth Crystal, Poor man's cocaine, Ice, Glass, Crank, Speed, Chalk, and Tina. How does meth contribute to the development of HFrEF? Abishak: So, first, let's understand how methamphetamine works. It has a chemical structure similar to dopamine and norepinephrine, and it gets taken up through the neuron transporter proteins. Once it enters the synaptic vesicles (storage sacs for neurotransmitters), it displaces and forces the release of large amounts of dopamine, norepinephrine, and serotonin into the synapse (the space between neurons). Additionally, meth blocks the reuptake of those neurotransmitters into the neuron, ensuring they remain in the synapse for a prolonged period. All this causes a downstream effect of increased sympathetic pathways in the body. Diagnosis Dr. Arreaza: The diagnosis starts with collecting a good history and performing a complete physical exam, and then we confirm with an echocardiogram.  Abishak: Yes, diagnosis requires both symptoms consistent with heart failure and objective evidence of reduced ejection fraction. Echocardiography is the primary diagnostic tool. We also measure BNP. In certain cases, cardiac MRI is used to evaluate myocardial fibrosis and exclude infiltrative or inflammatory etiologies. Coronary angiography may be performed if ischemic disease is suspected.Guideline-Directed Medical Therapy Dr. Arreaza: GDMT Guideline-Directed Medical Therapy started around 1987 when ACE inhibitors were proven to improve mortality in patients with heart failure. Then, during the following decades, many medications have been added to GDMT. Until around 2019–2022 we came out with the main 4 groups of medications that we know as GDMT. Let's talk about GDMT. Akbar: There are four core pillars in GDMT. First, an angiotensin receptor-neprilysin inhibitor, such as sacubitril with valsartan (Entresto), is preferred over ACE inhibitors when tolerated. This medication reduces mortality and heart failure hospitalizations. Second, evidence-based beta blockers including carvedilol, metoprolol succinate, or bisoprolol are used to reduce sympathetic overactivity and improve ventricular remodeling. Third, mineralocorticoid receptor antagonists such as spironolactone or eplerenone reduce fibrosis and improve survival. The Fourth pillar is SGLT2 inhibitors such as dapagliflozin or empagliflozin, which provide significant reductions in heart failure hospitalizations and cardiovascular mortality, regardless of diabetes status. Abishak: Other main parts of the treatment are diuretics, which are used for symptom control but do not reduce long-term mortality. Dr. Arreaza: As a recap: The current 4 pillars of GDMT are: ARNI/ACEi + β-blocker + MRA + SGLT2i)  Beta Blocker Considerations Dr. Arreaza: Sometimes we may be concerned about using beta blockers in active meth users. What did you read about it? Abishak: Historically, there was concern about unopposed alpha stimulation. However, in chronic heart failure, beta blockers remain essential. Carvedilol is often favored because it provides both alpha and beta blockade. Careful titration and close monitoring are critical.Reversibility and Remodeling Dr. Arreaza: Regarding meth-associated HFrEF, we have good news for meth users. Tell us about how reversible this condition is.  Akbar: It can be reversible. One of the most important aspects of this condition is that significant reverse remodeling may occur if the patient stops methamphetamine use and adheres to medical therapy. The Left ventricular ejection fraction can improve substantially and, in some cases, normalize. On the other end of the spectrum, continued meth use may lead to progressive fibrosis, ventricular dilation, and potentially irreversible damage, leading to death.Complications of meth-associated HFrEF Abishak: These patients are at increased risk for ventricular arrhythmias, sudden cardiac death, left ventricular thrombus formation, and progressive pulmonary hypertension. If the ejection fraction remains below 35 percent after at least three months of optimized therapy, implantable cardioverter-defibrillator (known as ICD) placement should be considered for primary prevention.Addiction Treatment as Core Therapy Dr. Arreaza: It sounds like GDMT cannot be done without talking about meth use disorder treatment. Akbar: Absolutely. Treating the myocardium without addressing the substance use disorder is ineffective. Primary care providers can be trained to manage addictions, but if resources are available, you can place a referral to addiction medicine, psychiatric support, behavioral therapy, and social support services. This is an essential part of the treatment. Sustained abstinence is the single most powerful predictor of recovery.Prognosis Abishak: Prognosis is highly dependent on abstinence. Patients who stop using methamphetamine often experience meaningful improvement in EF and even return to normal.  Dr. Arreaza: Yes, the key factor is complete abstinence, plus standard heart failure treatment. If the damage is mostly functional and inflammatory, recovery is possible. If there is extensive fibrosis (scar) recovery is less likely. Observational studies have shown that patients with meth-associated cardiomyopathy who stop using meth have significant improvement in EF over 3–12 months, fewer hospitalizations, and lower mortality. Akbar: Absolutely. Not all meth-associated cardiomyopathy behaves the same way. The extent of fibrosis determines recovery potential. Cardiac MRI with late gadolinium enhancement can help us estimate scar burden. Patients with minimal fibrosis often have better improvement with abstinence and medical therapy. Dr. Arreaza: So, MRI can actually help us determine the prognosis. Abishak: Yes, very much so. If MRI shows extensive fibrosis, the likelihood of full EF recovery is lower. That information helps us counsel patients more accurately. Akbar: Another key issue is right ventricular involvement. Methamphetamine can affect both ventricles. When the right ventricle fails, patients may develop severe peripheral edema, ascites, and hepatic congestion. Right ventricular dysfunction also worsens prognosis significantly. Dr. Arreaza: And pulmonary hypertension can also worsen the whole picture.  Akbar: That's correct. Meth is associated with pulmonary arterial hypertension independently of left-sided heart failure. In some patients, you may see a combined picture of both pulmonary vascular disease and right ventricular dysfunction. That can make management more complicated because pulmonary pressures may remain elevated even after EF improves. Dr. Arreaza: Tells us about the role of BNP in monitoring these patients.  Abishak: Serial BNP levels can help track response to therapy. Additionally, troponin may be elevated at times in meth users due to myocardial injury. Monitoring renal function is critical because many heart failure medications affect kidney function and potassium levels. Akbar:Other lifestyle modifications include sodium restriction, regular follow-ups, vaccination, and avoidance of other cardiotoxic substances such as alcohol or cocaine. Sleep disorders, especially OSA, should be evaluated because untreated OSA worsens heart failure outcomes. Dr. Arreaza: WhatIs there any role for wearable devices or remote monitoring? Abishak: Yes, increasingly so. Remote weight monitoring, blood pressure tracking, and symptom reporting can reduce hospitalization. In select patients, implantable hemodynamic monitors may help detect rising filling pressures before symptoms occur. Dr. Arreaza: It was a great discussion. Thank you, Abishak and Akbar for bringing all that valuable information to us. Let's wrap it up.     

In this episode, part 2 of our latest chat with @Formscapes , we map the emerging landscape of modern aether theory, tracing the structural ideas proposed by researchers who've appeared on DemystifySci. What begins as a survey becomes a deeper look at why so many independent models are quietly aligning around similar mechanical principles. As the conversation unfolds, the old boundaries between fields dissolve, revealing a shared intuition about the medium beneath observable phenomena. Ultimately, the shadows feel less like obscurity and more like the place where a new framework is taking shape.Part 1: https://youtu.be/R8MbZ8DI1ZAPATREON https://www.patreon.com/c/demystifysciPARADOX LOST PRE-SALE: https://buy.stripe.com/7sY7sKdoN5d29eUdYddEs0bHOMEBREW MUSIC - Check out our new album!Hard Copies (Vinyl): FREE SHIPPING https://demystifysci-shop.fourthwall.com/products/vinyl-lp-secretary-of-nature-everything-is-so-good-hereStreaming:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-herePARADIGM DRIFThttps://demystifysci.com/paradigm-drift-show00:00 Go! Requirements for an Aether Theory04:11 Aether as Foundational Medium08:12 Structural Ether and Material Complexity13:16 Limits of Mathematical Modeling20:07 Material Principles and Subunit Configuration23:13 Elasticity, Shear, and the Mechanics of Light26:42 Subunit Connectivity and Solid Ether Models32:12 Mass as a Foundational Concept36:00 Relational Physics and Michelson–Morley Reconsidered41:16 Observational vs Controlled Science47:44 Questioning Particle Physics Paradigms50:58 Structural Failures in Stellar Models57:37 Abstraction, Mystery, and Scientific Authority01:11:22 Cosmological Patchwork and Theoretical Contradictions01:19:09 Reclaiming Comprehensibility Through Structural Thinking01:25:07 A Renaissance of Shared Understanding #Aether, #quantumphysics, #Physics, #FoundationalPhysics, #Reality #MechanicalModels #fields , #physicspodcast, #philosophypodcast MERCH: Rock some DemystifySci gear : https://demystifysci-shop.fourthwall.com/AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98DONATE: https://bit.ly/3wkPqaDSUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci RSS: https://anchor.fm/s/2be66934/podcast/rssMAILING LIST: https://bit.ly/3v3kz2S SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

In this episode of The IT Experts Podcast, we take you inside our Client Intensive Event and lift the lid on what really happens when ambitious MSP owners come together to build better businesses.     This was our January 2026 Client Intensive Event, and it was the biggest room we have ever had. Over 60 MSP owners and team members gathered for two full days of structured thinking, planning, challenge, and collaboration. It was not a sit back and listen type of event. It was designed to stretch thinking, raise standards, and help every single business owner leave with clarity and a refreshed 16-week plan.     The Client Intensive Event is a core pillar of the MSP Scale System. Three times a year, our clients step away from their day-to-day operations and immerse themselves in focused work on the business. The structure is deliberate. We expand thinking through expert led sessions, then channel that insight into practical planning, peer discussion, and clear next steps. Every attendee leaves with an updated 16-week roadmap built around their own business priorities.     The theme this time was business maturity. We explored three key areas that underpin sustainable growth. Structural maturity, team and people maturity, and operational maturity. These are not theoretical concepts. They are the foundations that determine whether your MSP can grow with confidence or remains fragile beneath the surface.     On the structural side, we focused on governance and risk. Many MSP owners are strong technically and commercially, yet have never formally considered how governance protects value. We explored how to build a practical risk register, how to identify exposure across legal, supplier, regulatory and client concentration risks, and how to put simple mitigation in place. For several business owners, this created real light bulb moments. Scaling with confidence requires knowing your ducks are in a row. When you understand your risks, you make stronger decisions and protect long term value.     On the people side, we explored what makes a cohesive team. It is not only about systems and processes. It is also about how people feel inside the business. Trust, accountability, the ability to have difficult conversations, and clarity of expectation all drive performance. When those elements are weak, leaders experience frustration, repeated questions, slow decision making, and high staff turnover. The Client Intensive Event created space for honest reflection. Several owners recognised that team dysfunction often starts with leadership behaviour. That awareness is powerful. When leaders change how they show up, teams respond.     Operational maturity formed the third pillar. We examined how margin is often lost in operations rather than in finance. By connecting systems properly and using accurate data from sales, service, projects and finance, MSP owners gain visibility over efficiency and profitability. We drilled into practical examples around help desk structure and the dispatcher role, helping owners see where small operational refinements can unlock meaningful financial impact. For one new client, this approach has already uncovered significant hidden profit within their first 60 days.     Beyond the structured content, what continues to define every Client Intensive Event is the community. Observational learning is a powerful force. When MSP owners hear peers tackling similar challenges, sharing openly and supporting one another, confidence rises quickly. Trust builds. Relationships deepen. Competitors become collaborators in the pursuit of higher standards. The energy in the room this time reflected a step change in maturity across the community.     One of the most rewarding moments came when we stood at the front for a group photograph and realised how far the community has grown. What started with a simple vision to help more MSP owners scale with confidence has become a room full of experienced leaders committed to doing business better. That growth is not measured only in revenue. It is measured in confidence, clarity and ambition.     The Client Intensive Event always concludes with a rebuild of each owner's 16-week plan. Ideas are distilled. Priorities are clarified. Actions are documented. This discipline ensures that inspiration turns into implementation. It prevents overwhelm and replaces it with focused progress.     If you are serious about building a business that works for you rather than you for it, stepping into a structured environment like a Client Intensive Event can transform the way you think about growth. Business maturity is not accidental. It is developed deliberately, one focused cycle at a time.     At The MSP Growth Hub, our mission remains simple. Help MSP owners accelerate success and scale with confidence. The Client Intensive Event is one of the most powerful ways we do that.    Make sure to check out our Ultimate MSP Growth Guide, a free guide that walks you through a proven process to take your MSP from stuck to scalable, without working even more hours. It's 44 pages rammed with advice, insights and inspiration to help you decide what support is available to you now if you want to grow and scale your business. Click HERE to get your copy.    Connect on LinkedIn HERE with Ian and also with Stuart by clicking this LINK    And when you're ready to take the next step in growing your MSP, come and take the Scale with Confidence MSP Mastery Quiz. In just three minutes, you'll get a 360-degree scan of your MSP and identify the one or two tactics that could help you find more time, engage & align your people and generate more leads.  OR   To join our amazing Facebook Group of over 400 MSPs where we are helping you Scale Up with Confidence, then click HERE  Until next time, look after yourself and I'll catch up with you soon!   

16 years ago a chain of Chinese restaurants wanted to increase sales without changing the price.  They didn't change the product.  The service.  The chef.  The food.  Instead, they changed two words on their menu and increased sales by 18%.  The restaurants used the advice of today's guest on Nudge, Robert Cialdini.  Today, Cialdini explains the social proof principle, sharing how changing just two words could increase your sales. ---  Unlock the Nudge Vaults: https://www.nudgepodcast.com/vaults Read Cialdini's bestseller Influence: https://amzn.to/4prHb7Y Read the new and expanded Influence: https://amzn.to/43TY0jI Read Pre-Suasion: https://amzn.to/48hA6Qr  Read Yes! (Containing 60 Psyc-Marketing Tips): https://amzn.to/48ddNNf  Join 10,428 readers of my newsletter: https://www.nudgepodcast.com/mailing-list  Connect on LinkedIn: https://www.linkedin.com/in/phill-agnew/  ---  Today's sources:  Aune, R. K., & Basil, M. D. (1994). A relational-obligations approach to fund-raising: The effects of guilt and credibility appeals on compliance. Communication Research, 21(4), 486–498. Binning, K. R., Kaufmann, N., McGreevy, E. M., Fotuhi, O., Chen, S., Marshman, E., Kalender, Z. Y., Limeri, L. B., Betancur, L., & Singh, C. (2020). Changing social contexts to foster equity in college science courses: An ecological-belonging intervention. Psychological Science, 31(9), 1059–1070. Boh, W. F., & Wong, S.-S. (2015). Managers versus co-workers as referents: Comparing social influence effects on within- and outside-subsidiary knowledge sharing. Organizational Behavior and Human Decision Processes, 126, 1–17. Borman, G. D., Rozek, C. S., Hanselman, P., & Destin, M. (2019). Reappraising academic and social adversity improves middle school students' academic achievement, behavior, and well-being. Proceedings of the National Academy of Sciences of the United States of America, 116(33), 16286–16291. Cai, H., Chen, Y., & Fang, H. (2009). Observational learning: Evidence from a randomized natural field experiment. American Economic Review, 99(3), 864–882. Frank, R. H. (2020). Under the influence: Putting peer pressure to work. Princeton University Press. Goldstein, N. J., Cialdini, R. B., & Griskevicius, V. (2008). A room with a viewpoint: Using social norms to motivate environmental conservation in hotels. Journal of Consumer Research, 35(3), 472–482. Hallsworth, M., List, J. A., Metcalfe, R. D., & Vlaev, I. (2017). The behavioralist as tax collector: Using natural field experiments to enhance tax compliance. Journal of Public Economics, 148, 14–31. Jung, J., Busching, R., & Krahé, B. (2019). Catching aggression from one's peers: A longitudinal and multilevel analysis. Social and Personality Psychology Compass, 13(4), e12440. Linder, J. A., Meeker, D., Fox, C. R., Friedberg, M. W., Persell, S. D., Goldstein, N. J., Knight, T. K., Hay, J. W., & Doctor, J. N. (2017). Durability of benefits of behavioral interventions on inappropriate antibiotic prescribing in primary care: Follow-up from a cluster randomized clinical trial. JAMA, 318(14), 1391–1392. Meeker, D., Linder, J. A., Fox, C. R., Friedberg, M. W., Persell, S. D., Goldstein, N. J., Knight, T. K., Hay, J. W., & Doctor, J. N. (2016). Effect of behavioral interventions on inappropriate antibiotic prescribing among primary care practices: A randomized clinical trial. JAMA, 315(6), 562–570. Murrar, S., Campbell, M. R., & Brauer, M. (2020). Exposure to peers' pro-diversity attitudes increases inclusion and reduces the achievement gap. Nature Human Behaviour, 4(9), 889–897. Nolan, J. M. (2021). Social norm interventions as a tool for pro-climate change. Current Opinion in Psychology, 42, 120–125. Peterson, R. A., Kim, Y., & Jeong, J. (2020). Out-of-stock, sold out, or unavailable? Framing a product outage in online retailing. Psychology & Marketing, 37(4), 535–547.

Episode 278-Don’t Let Them Memory Hole Us Also Available OnSearchable Podcast Transcript Gun Lawyer — Episode Transcript SUMMARY KEYWORDS Mass shooting, Canada, gun laws, mental health, firearm license, self-defense, transgender, mandatory buyback, gun control, observational awareness, situational awareness, gun rights, New Jersey, firearm industry, de-banking. SPEAKERS Teddy Nappen, Speaker 2 Teddy Nappen  00:17 I’m Teddy Nappen, and welcome to Gun Lawyer. I wanted to kind of address this to the audience, as this has been kind of brushed over. There’s been multiple mass shootings, but there was one that caught my eye. They are trying to effectively bury in the stories. Like, I don’t even see it that much coming the news. The mass shooting in Canada! Every single one of the Left’s arguments on how to stop a mass shooting, everything that they push for, demonstrated in Canada failed. The Left always argues that stricter gun laws will prevent a mass shooting. If it saves one life. Even though  2.7 million lives are saved with self-defense uses of a firearm. If it saves one life. They always argue the accessibility of firearms –  that’s what leads to mass shootings. Teddy Nappen  01:15 So, I want to kind of lean into this story where nine people were shot and killed, 27 were injured in the mass shooting in Tumbler Ridge, British Columbia. (https://www.junonews.com/p/exclusive-family-confirms-identity) It was a man identifying as a woman, which, you know, that’s one of the other reasons why they’re burying the story. It doesn’t fit the narrative of the straight, white, right wing conservative as the shooter. So, obviously we can’t talk about it. You hear from the North District Commander Ken Floyd of the gun person. Yeah, person. Always good to not misgender the school shooter. He murdered his mother, but also shot his step brother as well. Don’t bring up that fact. Also, a troubled house life, and the school that he shot up, of course, he was thrown out of the school. Police had been called to the home multiple times. They had multiple instances with this individual who had reported mental health problems. Huh, interesting. Teddy Nappen  02:21 Oh, and it gets better. So, the suspect had a firearm license, which, by the way, in Canada, you cannot possess a firearm for self-defense – only hunting. Keep that in mind. Supposedly, the guns recovered were a long gun and a “modified handgun”. They don’t go into details as to what was modified. So, the suspect, the shooter, the man identifying as a woman, I’m going to repeat that, the suspect had dropped out of the Tumbler Ridge Secondary School four years ago and was not a student at the time. So, police had attended the suspect’s residence multiple times in the past several years, dealing with mental health occurrences. Hmm, wonder why? When he started identifying as a woman? You know, that usually leads to that 42% suicide rate. The only group that is close to that rate is paranoid schizophrenics. But you know, facts are transphobic and homophobic, apparently. This included one of the attendants where, two years ago, the firearms were seized under criminal code. He was Red Flagged! Oh, he had multiple mental health instances. So, obviously we’ve got to seize his guns. The very argument by the Left to stop mass shootings. But, of course, because the man identified as a woman, then of course, well, we can’t, we don’t want to be transphobic. Let’s give him, oh, sorry, her back his firearms. Teddy Nappen  03:53 And, of course, suspect was born a biological male and then started transitioning six years ago. So, six years  ago, he started transitioning and identified as a woman. Two years ago, the firearms are seized, so then he can say, oh, sorry, I think I’m a woman, so give me back my firearms, even though the police have come multiple times for multiple mental health incidents. Other than that, though, let’s give him back his guns. So, right there we have a clear demonstration of the fact that his firearms were seized and then he got, you know, Red Flagged. They actually have it. I pulled the law under their Public Safety website emergency prohibition order. (https://www.publicsafety.gc.ca/cnt/cntrng-crm/frrms/rd-flg-lws-en.aspx) A judge issues the order if they believe the individual poses a risk to themselves or others. When the order was issued, firearms, and firearm license and other documents and other weapons may be removed up to 30 days, and you have a hearing date. He goes to the hearing date and says, I want my guns back. And here they are given back and then does the shooting. The level. It’s just so disgusting. The system works every time. He got the guns back, and then boom, goes right into a mass shooting. Teddy Nappen  05:12 By the way, Canada is one of the most strictest places you could find for a firearm. You cannot get firearms for self-defense uses. They ban every form of semi-auto possible. Their laws are extremely, extremely difficult in order to get firearms. Also, Trudeau did a freeze on the sale, purchase, or transfer of handguns, stopping all handgun purchases. It’s still in effect. So, you can’t get a handgun to defend yourself. You have no means of purchase except for hunting, and every single one of the anti-gun, the gun rights oppressors, the Left’s whole argument about trying to stop mass shootings. We need all of these things. Well, Canada had all these things. A ban on extended mags. All the bans that you could have on every semi-auto possible, and it still wasn’t enough. And still led to a mass shooting. Every protocol failed. Teddy Nappen  06:13 And by the way, this isn’t the first. Quite frankly, Canada is the inventor of the mass shooter. On December 6, 1989, at Montreal’s Ecole Polytechnique 14 women were killed as a student went through shooting up the place. (https://www.thecanadianencyclopedia.ca/en/article/polytechnique-tragedy) And that was their justification for all their anti-gun agendas. This is what they said, oh, we’ve got to go after firearms. He just walked through the school and just started shooting the people. They had no means of defense. Then in 2006 a gunman killed one woman and injured 19 others at Montreal college being (https://www.theguardian.com/world/2006/sep/15/topstories3.internationaleducationnews) He was shot dead by the police saying he wanted to die like Romeo and Juliet. Okay. The man must have been an acting major, a fan of Shakespeare. Teddy Nappen  07:00 And then cut to, I love this one. In 2020, Canada’s deadliest mass shooting. The shooter was Gabriel Wortman. His wife, Lisa Banfield, goes into details in her book, “The First Survivor: Life With Canada’s Deadliest Mass Shooter.” Wortman walks through and kills 22 people in the span of 13 hours, dressed up as a Mountie. He went across a 200 kilometer stretch. Shooting people for 13 hours, 13 hours. Going up and down, shooting and killing people. And no one was there to defend themselves. No one has any guns. This is in 2020. But the Left doesn’t want you to know that. Teddy Nappen  07:44 Just like they don’t want you to know that every time when they hailed Venezuela as the great socialist experiment, when you have Bernie Sanders, who was honeymooning in the Soviet Union and arguing that Cuba has the best healthcare. They always move the goal post or they’ll memory hole it. Trying to make the argument. Oh, this doesn’t fit the narrative. So, we can’t talk about this. That’s how disgusting these people are. And by the way, they even have their mandatory buyback program in Canada. By the way, it’s a complete failure, too. They got like 200 guns. No one’s complying. And that was the thing that The Trace even argued. They said that the hardest part about running a mandatory gun buyback is compliance. Because unless you’re going to go door to door at the barrel of a gun and stealing people’s property, gun buybacks, mandatory gun buyback programs fail every time. So, this ends the debate. This factually ends the debate that every single means of gun control that they argue to stop a mass shooting will not stop a mass shooting. Teddy Nappen  08:52 Not to mention that it is part of our culture where guns are. It’s, yeah, I’m trying to remember the numbers, and it was like 350 million. I can but it’s the we already have a mass number of firearms in the United States. So, the Nirvana fallacy, logical fallacy of trying to argue, if we just get rid of all the guns, there’ll be no mass shootings. No. Because the Left need to understand that there is evil in this world. There is evil. Yeah, they always say. They always try to justify it. Like, oh, I’m poor, I’m impoverished, I’m an illegal who came to this country. They always argue that, trying to justify evil and just accepting the fact. They try to mislabel evil. There is evil in this world, and you have to accept that there will always be terrible people wanting to commit terrible acts. Cut to, you know, taking a car and just running into a crowd of people at a Christmas parade. Cut to the U.K. with random stabbings and their mass pile of rapes that they don’t want to talk about. There will always be evil in this world, and they have to accept it. That is what needs to be brought. So, going on that cheery note, let’s talk about our good friends at WeShoot. Teddy Nappen  10:19 Well, WeShoot is a range in Lakewood. It’s an indoor range where both myself and my father go to shoot. We love to go there. WeShoot is conveniently located right off the Parkway. They have some cool specials that I want to tell you about. The Smith M&P 9M 2.0 Compact is ready to roll. They have that. They’re also offering an M&P 9M 2.0 in metal. So, you can have your choice in metal or polymer. There is the Vortex Triumph, which is in all new optics. Pretty cool. The Vortex makes some good stuff. My father has some Vortex on his guns. They also have the Ross Martin RM1C, which is a striker fire, compact pistol that is really taking the gun world by storm. You should check out the Ross Martin. It’s a really good gun. And, of course, you want to check out the WeShoot girls. They’re featuring a number of folk, including Kristen Fernicola. Go to their website, www.weshootusa.com. You can see all these wonderful guns and models posing with wonderful guns. You will be glad you went to look at all that, I’m sure. And make sure you check out the range at WeShoot. Go to the range. You can go some fantastic training, too. Great pro shop right there in Lakewood, New Jersey. weshootusa.com. Teddy Nappen  11:44 I also want to mention our good friends at The Association of New Jersey Rifle & Pistol Clubs. (ANJRPC.org) They’re quite busy fighting in the courts and with the legislation in Trenton. Murphy’s gone, but we did get some new laws. Of course, it’s a very tough environment, but we all get some changes that are critical. I’m glad to see modifications, although completely stopping when the folk have all the power is tough. The Association has made a big difference. We’re thankful, too. Because without The Association of New Jersey Rifle & Pistol Clubs, we would have no unified voice of an umbrella organizations, of our clubs and organizations. You need to be a member of The Association of New Jersey Rifle & Pistol Clubs. Go to anjrpc.org and join today. You’ll get a newsletter. The best newsletter in the state on guns. You’ll see email alerts, and you’ll know that what’s going on when it comes to our gun rights in New Jersey. That’s anjrpc.org. Teddy Nappen  12:39 I would also like to shamelessly plug my father’s book, which is New Jersey Gun Law. The Bible in New Jersey gun law. It’s over 500 pages with 120 topics, all questions and answers. It’s your guidebook to not becoming a GOFU in New Jersey. And man, let me tell you some of the times people call up and ask, and it’s after the fact. I’m like, did you read the book? Did you read the book? We’ll still fight and defend you, but it would have been a lot easier if you never had the problem in the first place. And most of the clients would agree with that, I’m afraid. So, get your copy of the book today. Go to EvanNappen.com,  EvanNappen.com. Get your copy of New Jersey Gun Law. Teddy Nappen  13:23 So, let’s get to Press Checks. As you know, Press Checks are always free. This is something I find very important, because I think people are forgetting, when the Left had their unfettered power. That’s why you’re seeing a lot of the Left moving to the trying to pivot to the center. Saying, like, oh yeah, we know, mass migration is bad. Yeah, yeah. And trying to, like, epically fail when asked how many genders there are. They can’t define what a woman is. But we have to remember that it’s not just the Left, but it’s the insidious institutions that they abuse. The fact that this is a term that I’m pushing for because it’s a fact. It’s gun deserts. The Left realize now that they can’t win in the public square of debate. Because with gun control, we can easily, we can easily defend and fight against it. And we can push back on every one of their points, because every one of their points are nonsensical. They’ve lost the media where we have alternative tech. There’s Rumble, and you have all the voices. X has become slightly more free. And because a lot of the big tech companies want to use AI, they’re allowing, okay, yeah, we’ll let the conservatives have their points and speak. Teddy Nappen  14:57 So, this is the one bid. It’s the financial institutions. If you all remember the heavy issue of de-banking. I caught this article, and I was like, oh yeah, I remember that issue. (https://www.nraila.org/articles/20260209/jp-morgan-in-growing-trend-backtracks-on-anti-gun-policies) I love how JP Morgan says they’re going to roll back the de-banking that they were committing against gun shops and firearm companies. So, to give a little history lesson, this comes right from the NRA-ILA’s article of JP Morgan’s backtracking. I mean, this goes back to Obama Biden, like the 2010s, where firearm-related businesses were having trouble with Bank of America. Even though they said they didn’t have any corporate policy, we know they’re lying, of course. And then the allegations were getting worse, and Bank of America said, no, no, we don’t have any policy. Then finally, in 2014 they admitted under Operation Choke Point where they threatened to throttle any institution that exercises Second Amendment rights by pressuring banks to drop business, to drop businesses in the firearm industry. So, thankfully, President. Trump got in and stopped that operation. But it proved the point. We were right. The banks were weaponized against the firearm industry. They were trying to go after any form of gun shops or any firearm industries. You know, they can’t get a loan. Then my favorite one was when they were trying to do the credit card scheme. They were trying to track firearm purchases on credit cards. Teddy Nappen  16:34 Also, I love this one where they would pressure firearm industry groups to not sell certain semi-automatic firearms, and also cutting back on standard capacity mags. They like to say high capacity, but it’s just standard capacity. Prohibiting the sale of magazines. Then, of course, the Left would tote saying, look at the firearm industry. They support our anti-gun movement. Well, you’re trying to de-bank me and lose my business. So, I have to agree with you. You know, if you point a gun at someone and demand them to say things, they’ll say things. It’s so disingenuous. At the point where there was a 2019 hearing where the institutions were hauled in. Coming to answer questions that they delved in when it came to banks working with firearm industry and forcing them to push the anti-gun policies. It’s the level of disgusting nature that comes into play. We need to remember that. We need to remember these institutions. Because when the pendulum swings, which it will, at some point, they will get back to business as usual. Attacking our rights. And even President Trump, right back in office, 2024. He comes back in and says to Davos. He gives a huge speech and points to the CEO. JP Morgan and everybody else, I hope you start opening your banks to conservatives. What you’re doing is wrong. Pointing it right out. Not saying, oh, the firearm industry. No, conservatives. Because that’s what it is. It’s conservatives that they are de-banking. It’s conservatives they are attacking and weaponizing. Teddy Nappen  18:21 And even going back to the, I think it was the National Shooting Sports Foundation that even addressed this exact issue. In 2021, they testified in a Congress hearing stating that JP Morgan’s Chase would not lend to manufacturers of modern sporting rifles. There’s your proof, right there. So, remember this. Do not trust the big tech companies. Do not trust the banks. Because right now, the culture has shifted, but they are fully willing to get back. If you look at the donors to Kamala Harris, they all donated to Kamala. They all donated. They all heavily donate to Democrats. Only now, because we’re in power, they’re like, oh yeah, we’re for you guys. Yeah, okay. Enjoy chasing that AI trend while you guys won’t de platform us. But we need to remember that. So, we need to embrace and look to other means, because this is the games they play. We need to find ways around that. Teddy Nappen  19:25 It’s time to finish off with the GOFU, everyone’s favorite. We need to. Also, this is a kind of a lesson in observational awareness. Jeff Cooper preached that idea of observational awareness. He even made a little game of X’s and O’s. Where, if you go into any room or place, you make sure you see everyone and make an O. And as you’re walking through, if you miss somebody who saw you first, give that one an X. Play that game in your head as a scoring method. Yeah, because observational awareness is key. I’m going to highlight that with an actual article from USACarry.com. (https://www.usacarry.com/man-fatally-shoots-attacker-while-playing-pokemon-go-in-anderson-indiana/) A man was attacked while playing Pokémon Go in the woods. He was walking through the woods and was playing Pokémon Go. A 51-year old businessman was playing Pokémon Go, a scavenger hunt, on his phone, and he was ambushed by a homeless man who punched him in the back of the head and stole his phone. At which time, he, you know, drew his firearm and fatally shot the man. It was ruled fully justified, because, first of all, you’re getting punched in the back of the head. People have died from that. And look, there may be more to the story of why it was justified, but the police and the prosecutor found that it presented and seemed like a strong case of self-defense. The fact that he was ranting and raving. But this is the point. This is a clear demonstration. He could have avoided that whole encounter, and it could have gone very bad very quickly. Because all it took is one Left wing prosecutor to say he shot an unarmed man, and his life would have been ruined. Observational awareness, situational awareness. Keep your head on a swivel. That is the GOFU. Don’t be a GOFU. Teddy Nappen  21:19 This is Teddy Nappen reminding you that gun laws do not protect honest citizens from criminals. They protect criminals from honest citizens. Speaker 2  21:30 Gun Lawyer is a CounterThink Media production. The music used in this broadcast was managed by Cosmo Music, New York, New York. Reach us by emailing Evan@gun.lawyer. The information and opinions in this broadcast do not constitute legal advice. Consult a licensed attorney in your state. Downloadable PDF TranscriptGun Lawyer S5 E278_Transcript About The HostEvan Nappen, Esq.Known as “America's Gun Lawyer,” Evan Nappen is above all a tireless defender of justice. Author of eight bestselling books and countless articles on firearms, knives, and weapons history and the law, a certified Firearms Instructor, and avid weapons collector and historian with a vast collection that spans almost five decades — it's no wonder he's become the trusted, go-to expert for local, industry and national media outlets. Regularly called on by radio, television and online news media for his commentary and expertise on breaking news Evan has appeared countless shows including Fox News – Judge Jeanine, CNN – Lou Dobbs, Court TV, Real Talk on WOR, It's Your Call with Lyn Doyle, Tom Gresham's Gun Talk, and Cam & Company/NRA News. As a creative arts consultant, he also lends his weapons law and historical expertise to an elite, discerning cadre of movie and television producers and directors, and novelists. He also provides expert testimony and consultations for defense attorneys across America. Email Evan Your Comments and Questions  talkback@gun.lawyer Join Evan's InnerCircleHere's your chance to join an elite group of the Savviest gun and knife owners in America.  Membership is totally FREE and Strictly CONFIDENTIAL.  Just enter your email to start receiving insider news, tips, and other valuable membership benefits.   Email (required) *First Name *Select list(s) to subscribe toInnerCircle Membership Yes, I would like to receive emails from Gun Lawyer Podcast. (You can unsubscribe anytime)Constant Contact Use. Please leave this field blank.var ajaxurl = "https://gun.lawyer/wp-admin/admin-ajax.php";

This episode explores tadalafil (Cialis) as a potential longevity drug, though no randomized human trials prove it extends lifespan. Cialis works by blocking PDE5, enhancing nitric oxide signaling, and improving blood flow through vasodilation. Originally approved for pulmonary hypertension, it's also used for erectile dysfunction and BPH. Its 36-hour half-life makes it superior to Viagra for continuous longevity effects.   The host frames vascular aging and endothelial dysfunction as key drivers of age-related diseases (heart disease, stroke, dementia, kidney disease). Observational data shows Cialis users have 44% lower mortality, fewer cardiovascular events, reduced dementia risk, and lower mortality in diabetics. Additional benefits include improved cardiac function, reduced infarct size, arrhythmia suppression, and regression of left ventricular hypertrophy. A 2024 meta-analysis found it lowers hemoglobin A1C, possibly via improved microvascular perfusion, insulin sensitivity, and mitochondrial function.   Cialis crosses the blood-brain barrier and may improve neurovascular coupling and hippocampal plasticity, potentially benefiting those with or at risk of dementia. Safety is generally good with long-term daily use (2.5–5 mg), though cautions include avoiding use with nitrates, low blood pressure, or certain retinal disorders. Common side effects are headache, nasal congestion, and acid reflux. The host recommends consulting a doctor and references potential synergy with telmisartan.   Tadalafil (Cialis) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) Sildenafil (Viagra) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a699015.html](https://medlineplus.gov/druginfo/meds/a699015.html)   Key mechanisms mentioned Nitric Oxide (NO) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK554485/](https://www.ncbi.nlm.nih.gov/books/NBK554485/) Cyclic GMP (cGMP) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK542234/](https://www.ncbi.nlm.nih.gov/books/NBK542234/)   Conditions mentioned in the episode Benign Prostatic Hyperplasia (BPH) — MedlinePlus: [https://medlineplus.gov/benignprostatichyperplasia.html](https://medlineplus.gov/benignprostatichyperplasia.html) Pulmonary Arterial Hypertension (PAH) — MedlinePlus: [https://medlineplus.gov/pulmonaryhypertension.html](https://medlineplus.gov/pulmonaryhypertension.html)   Blood pressure drug mentioned Telmisartan — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a601249.html](https://medlineplus.gov/druginfo/meds/a601249.html)   Other longevity / comparison drugs mentioned Metformin — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a696005.html](https://medlineplus.gov/druginfo/meds/a696005.html) Sirolimus (Rapamycin) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a602026.html](https://medlineplus.gov/druginfo/meds/a602026.html)   Side-effect helper mentioned Ibuprofen (Advil) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682159.html](https://medlineplus.gov/druginfo/meds/a682159.html)   Dementia meds mentioned Donepezil (Aricept) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a697032.html](https://medlineplus.gov/druginfo/meds/a697032.html) Amantadine — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682064.html](https://medlineplus.gov/druginfo/meds/a682064.html)   Lab markers mentioned Hemoglobin A1C (HbA1c) test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/](https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/) Insulin in blood test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/insulin-in-blood/](https://medlineplus.gov/lab-tests/insulin-in-blood/)   People referenced (where the claims were mentioned) Huberman Lab (Dr. Andrew Huberman) — site: [https://www.hubermanlab.com/](https://www.hubermanlab.com/) Clip about low-dose tadalafil (2.5–5mg) — X post: [https://x.com/tbpn/status/2022350426394534334](https://x.com/tbpn/status/2022350426394534334) Bryan Johnson (Blueprint) — site: [https://blueprint.bryanjohnson.com/](https://blueprint.bryanjohnson.com/) Dr. David Sinclair (Harvard profile) — site: [https://sinclair.hms.harvard.edu/people/david-sinclair](https://sinclair.hms.harvard.edu/people/david-sinclair)   Show Notes   00:00 Welcome to the Hart2Heart Podcast. 01:56 What Cialis Is: PDE5 Inhibition, cGMP & Nitric Oxide Explained 03:43 Approved Uses & Origin Story: Pulmonary Hypertension, ED, and BPH 05:33 Why Cialis Over Viagra: 36-Hour Half-Life & 24/7 Vascular Benefits 06:52 Vascular Aging 101: Endothelium, Perfusion, and Why It Drives Disease 11:14 What the Human Data Shows: Observational Evidence for Mortality, CVD & Dementia 13:04 Mechanisms Deep Dive: Heart Protection, Heart Failure, and Anti-Atherosclerosis 15:02 Cialis for Diabetics: Lowering A1C and Improving Insulin Sensitivity 16:21 Brain Effects: Blood–Brain Barrier, Neurovascular Coupling & Dementia Potential 18:21 Safety, Who Should Avoid It, and Daily Longevity Dosing (2.5–5 mg) + Wrap-Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this episode of the progesterone series, Dr. Brendan McCarthy — Chief Medical Officer of Protea Medical Center in Tempe, Arizona — explores the often misunderstood relationship between progesterone, estrogen, and breast health. For decades, women have been taught to fear their breasts and fear hormones. While awareness matters, fear is disempowering — and it has left many women confused about what's actually happening in their bodies. In this episode, we discuss: Why breast tissue is dynamic, not static How estrogen stimulates growth and progesterone restores balance The role of progesterone in breast tissue maturation and architecture Why dense or fibrocystic breasts often reflect unopposed estrogen How restoring ovulation and progesterone can reduce breast pain and density in some women The difference between natural progesterone vs synthetic progestins Where the fear around progesterone and breast cancer really came from Progesterone is not something to fear — it is a hormone of organization, balance, and maturation. Understanding how it works allows women to approach breast health with clarity instead of anxiety.

What does the science actually say about red meat after breast cancer? In this episode, Laura Lummer begins a new series focused on separating nutrition myths from facts. The conversation was sparked by hearing a physician recommend a low-fat, high-fiber diet with no red meat to an entire room of cancer patients. Laura explains why that kind of advice ignores bio individuality and why nutrition science is far more nuanced than headlines suggest. This episode breaks down how observational studies work, what statistically significant means, and why one of the most cited red meat studies cannot be used to create universal food rules. Topics include: Observational studies vs randomized trials Self-reported diet recall and its limitations What statistically significant really means The Stanford SWAP-MEAT trial explained Why one diet does not fit everybody   Let's Connect! If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025. 00:39   Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al. 06:23   Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al. 11:17   Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al. 15:35   David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D. 17:27   William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research" by Roger S. McIntyre, M.D., F.R.C.P.C., et al. 24:04   Daniel S. Pine, M.D., discusses "Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial" by Carlos M. Grilo, Ph.D., et al. 26:06   Carolyn Rodriguez, M.D., Ph.D., discusses "Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders" by Emily R. Stern, Ph.D., et al. 30:26   Sean T. Lynch, M.D., discusses "From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy" by Rathisha Pathmathasan, D.O., et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  

In this research review episode of the By Any Means Coaches Podcast, the conversation dives deep into the impact of scaled equipment—lower rims, smaller basketballs, and modified environments—on youth basketball development. Through the lens of current research and the constraints-led approach, the episode challenges long-held assumptions about “toughening kids up” with regulation equipment and instead explores how properly scaled tasks can accelerate skill acquisition, improve movement quality, and foster long-term engagement with the game.Beyond shooting percentages, this episode explores how scaled environments influence biomechanics, perception, psychology, and decision-making. From earlier emergence of adult-like mechanics to increased confidence, creativity, and adaptability, the discussion highlights why many technical “flaws” are actually functional solutions to poorly designed tasks—and how fixing the environment often fixes the movement without excessive coaching cues.Episode Timestamps00:00 – Introduction and context for the research review 00:26 – Why scaled equipment is worth revisiting through research 01:40 – Overview of studies and research synthesis approach 02:07 – Performance vs development vs psychology 02:42 – Key findings from the research 03:55 – Shooting mechanics, arc, and energy transfer 04:42 – Trunk lean, elbow flare, and acceptable technique ranges 05:54 – Why mechanics improve without technical instruction 06:24 – Psychological benefits: confidence, enjoyment, and volume 07:31 – Motivation, success, and long-term engagement 08:11 – Spacing and offensive behavior in scaled environments 09:02 – Finishing degrees of freedom and creativity 09:42 – Movement exploration with smaller basketballs 11:09 – Early developer bias created by regulation equipment 12:13 – Compensation vs challenge in youth shooting 12:38 – Depth perception and shooting range development 13:46 – Adaptability vs rigid technique 14:17 – Constraints-led approach applied to shooting 15:39 – Why many shooting drills are compensatory fixes 16:26 – Observational learning and imitation 18:05 – Finding the optimal challenge point 19:20 – External focus and freer shooting behavior 20:11 – Rhythm, sequencing, and adaptable skill development 20:37 – Practical coaching implications 21:44 – What to do when scaled equipment isn't available 22:38 – Playing athletes up or down based on physical maturity 23:14 – Supplementing constraints with cues and observation 24:57 – Sport crossover effects and task design solutions 25:34 – Final takeaways and practical applicationsCoaching Resources: https://www.byanymeansbasketball.comBAM Blueprint Book: https://www.byanymeansbasketball.com/bam-blueprintIf this episode challenged the way you think about youth development: share it with a coach or parent who needs to hear it. For more research-driven insights and practical coaching tools, subscribe to the By Any Means Coaches Podcast and explore our full library of resources at By Any Means Basketball.

We're stepping out of our Medicine on the Go series for a rapid-response episode on something hitting all of us hard right now: **influenza**. A lively debate among our colleagues sparked this conversation—especially around a newer flu antiviral, baloxavir (Xofluza). Who's using it? When does it make sense? How much does it cost patients? And how does it really compare to the longtime staple oseltamivir (Tamiflu)? The questions came fast, the opinions were strong, and we knew it was time to dig in. With flu season in full swing, this episode is all about practical decision-making at the bedside. Back to Basics: How Flu Antivirals Work To help break it all down, we welcome back our trusted ED pharmacist, Haley Burhans. We begin with a quick review of how influenza antivirals have evolved. , approved in 1999, was the first widely used antiviral and works by blocking the neuraminidase enzyme. Over time, concerns about resistance led to the development of newer options. That brings us to baloxavir (Xofluza), approved in 2018. Xofluza works differently by stopping viral replication earlier in the virus life cycle. While both medications aim to shorten illness and reduce complications, they differ in how they work, how they are dosed, and which patients benefit most. Who Should Get What—and When? Next, we focus on real-world ED decision-making. Who should receive Tamiflu, and who is a good candidate for Xofluza? We review use in children, pregnant patients, hospitalized patients with severe or worsening illness, immunocompromised patients, and those at higher risk due to conditions like asthma, lung disease, diabetes, heart disease, obesity, or older age. Timing is critical. Both medications work best when started within 48 hours of symptom onset. However, oseltamivir is still recommended even after that window for patients who are hospitalized or severely ill. We also discuss when antivirals can be used for post-exposure prpphylaxis. What Does the Evidence Say? We then take a closer look at the data behind antiviral treatment. Both Tamiflu and Xofluza shorten the time to symptom improvement. Observational studies suggest oseltamivir may reduce hospital length of stay and in-hospital death in adults and shorten hospital stays in children. Trial data also suggest baloxavir may be more effective against influenza B. We compare dosing strategies—five days of twice-daily Tamiflu versus a single-dose Xofluza—and review side effects and pediatric considerations. Real-World Barriers: Access and Cost Finally, we tackle the practical issues clinicians face every day. Tamiflu is widely available and familiar to most providers. Xofluza, on the other hand, often requires prior authorization and may be harder for patients to obtain. We discuss insurance barriers, out-of-pocket costs, manufacturer coupons, and situations where Xofluza may or may not be a realistic option. Take-Home Message This episode is a practical, evidence-based conversation designed to help emergency clinicians make confident decisions during flu season. Whether you're treating a high-risk patient, considering a single-dose option for uncomplicated flu, or simply trying to stay current, this discussion delivers clear, useful guidance you can use on your next shift! What's your go to flu treatment? What other medications would you like to learn more about? Hit us up on social media @empulsepodcast or at ucdavisem.com Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Professor of Emergency Medicine at UC Davis Guests: Haley Burhans, PharmD, Emergency Medicine Clinical Pharmacist at UC Davis Resources: CDC: Influenza Antiviral Medications: Summary for Clinicians AAP: Recommendations for Prevention and Control of Influenza in Children, 2025–2026: Policy Statement ACEP Influenza Resources and Updates **** Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.

In this (rather delayed!) October round-up, Iain Beardsell and Simon Carley catch up on recent St Emlyn's blog posts and papers that continue to shape emergency and resuscitation practice. The discussion moves across trauma, analgesia, cardiac arrest physiology, emergency department systems, and antimicrobial stewardship—less about novelty, more about what actually holds up on shift. Trauma and haemorrhage The episode opens with a discussion of the FIRST-2 trial, examining fibrinogen concentrate and prothrombin complex concentrate versus fresh frozen plasma in severe traumatic haemorrhage. Despite promising physiological theory, the trial shows no meaningful reduction in blood product use compared with standard care, reinforcing the ongoing role of FFP in early trauma resuscitation. Upper limb injuries and regional anaesthesia The team explore the SUPERB trial comparing supraclavicular brachial plexus blocks with Bier's blocks for upper limb reductions. Both techniques provide excellent analgesia. The conversation reflects on changing practice, procedural sedation pressures, ultrasound access, and how physical space—not evidence—often dictates what we do. Cardiac arrest: signals worth paying attention to Three recent cardiac arrest papers are reviewed, focusing on physiological markers rather than new devices: End-tidal CO₂ as a CPR quality target Ventilation strategies during arrest, including chest-compression-synchronised ventilation Cerebral oximetry as a potential prognostic signal These are not definitive answers, but they point towards cardiac arrest management that is more physiological and less ritualistic. Emergency department systems: repair, not reinvention A reflective discussion on “designer repair” challenges the idea that emergency departments need constant transformation. Instead, the focus shifts to recognising and supporting the clinicians quietly holding fragile systems together every day—and why fixing small, broken things often matters more than grand redesigns. Sepsis and antibiotics The episode closes with a critical look at broad-spectrum antibiotic use in suspected sepsis. Observational data suggest significant overtreatment and real harm, reinforcing the need to pause, think, and choose the right antibiotic—not just the fastest one. This episode is a reminder that good emergency medicine is rarely about silver bullets. It's about judgement, physiology, and paying attention to what actually works in the real world. About MedPod Learn MedPod Learn is a medical podcast player designed to help turn listening into structured learning, with tools to support reflection, CPD, and appraisal. Available on the App Store and Google Play.

This playlist is 67% vinyl friendly. Poor. ‘In the year 2021, few turntables have captured the essence of that time the way that the Old Future Turntable and Speaker has. The silhouette of the player itself pays homage to ’70s architecture in Seoul. Slanted roofs were common during that era, and when you place the turntable and speaker side-by-side, they look like part of a ’70s city skyline. Some vinyl-lovers may not like this product initially because a flat, horizontal turntable would be preferred for sound quality. For those who care about audio quality over aesthetics, the turntable's legs are adjustable, so you can make the table more even‘. – yankodesign.com Looks like it could more readily blow out hot and cold air than music. Any track marked * has been given either a tiny or a slightly larger 41 Rooms tweak/edit/chop and the occasional tune might sound a bit dodgy, quality-wise. On top of that, the switch between different decades and production values never helps in the mix here. Lyric of Playlist 147 ‘Observational, not sexist‘ noted Jean-Jacques Burnel. 00.00 (Intro) THE FLAMINGOS – Stars (Edit) – Unreleased demo – 1983. Episode #1 for info. 00.41 NEW ORDER – Face Up – Low-life, LP – Factory – 1985 Face Up? More like Jump up, given the NO audience reaction when the chorus kicks in. 05.25 THE YOUNG GODS – Mes Yeux De Tous – Appear Disappear, 2LP – Two Gentlemen Records – 2025 Given that in the mid ’80s they were initially loosely bandied around in the same ‘industrial’ bag as my ‘charges’ Click Click I’ve heard very little of their lengthy and regular catalogue. This though is a mighty tune. 09.19 BLAWAN – Toast – Dismantled Into Juice, 12″ EP – XL Recordings – 2023 Nicely odd, with a ‘chorus’ that makes me smile. 11.56 BASETANK – Got Some Skills – The New Breed, v/artists promo only CD – Detonation – 1999 If it wasn’t for the 35 year age gap I might have said the vocalist on Got Some Skills and the modern day Microwave Man and his electric dirt bike online ‘Let Me Tell You Something, right?‘ words of wisdom sketches were of the same family. 15.44 9 LAZY 9: Turn Me Loose; UP, BUSTLE & OUT: Nightwalk; DJ FOOD: Klutes Groove; DJ TOOLZ: Rusty Goes GaGa; FUNKI PORCINI: It’s A Long Road – The Morning After The Night Before (one half of a CD free with DJ magazine – 1994 Old skool mixing from Cold Cut. ‘It’s (been) a long road… ‘ indeed. 22.00 HERCULES & LOVE AFFAIR (feat HIPS & LIPS) – Someone Else Is Calling, 12″ EP – Stratasonic – 2025 The sort of hypnotic beats that could have fitted in with a Winkles, Bedford set list back in the ’80s… although someone might point a sound or two here didn’t exist back then. 26.12 FUNKY GREEN DOGS – The Way * – 12″ – Twisted – 1997 ‘Anyone who ever liked That Sound from the Murk camp will like this just as much, even if they do whinge that it’s very similar to their previous favourite. The original is the heart-winner with its quivering vocal and acid-meets-funk groove, but the mixes are all attractive in their respective ways – Farley & Heller plod sweetly, Canadian Crash Productions do something along the same lines. Dirty White Boy rock and roll and Club 69 kick up a noisy messy rumpus. The best track of all is possibly the excellent FGD way-out beats. **** Daisy & Havoc, Record Mirror (Music Week), 10.5.97 Tough, liquidy goings on from the Murk camp. I was a fan. 32.51 JOY – Fragile Space – 7″ – DB-Low – 2000 ‘Isaac Hayes meets Led Zeppelin‘ ran the press release for Joy Jones’ one-off (at the time) dip into music, and there’s something sad about a single of substance that didn’t do enough for the artist to build on. 35.52 TALKING HEADS – Listening Wind – Remain In Light, LP – Sire – 1980 Just checked. This is the last in a near complete run of the album’s tracks making it to 41 Rooms. So, that must make Remain In Light a bit of a classic to my ears. 39.36 THE SOULSAVERS – Rumblefish – Beginning To See The Dark 12″ – Ghost Ride Music – 2002 The sort of drifting beats thing that would crop up late night/early morning on KISS FM or maybe Ross Allen radio shows of the time. 43.28 BETHANY & RUFUS – 900 Miles – 900 Miles, CD only – Little Monster Records – 2005 With Bethany being the daughter of ’60s folk group, Peter Paul and Mary’s Pete Yarrow, an ancient tune reworked. And it’s a cello apparently, not a double bass. 46.48 STARGARD – (Theme Song From) Which Way Is Up – 7″ – MCA -1977 As funky now as the day it was delivered. I was 20… and this would have been hitting someone’s decks at Bedford’s Nite Spot, Spectrum, Pilgrims, The Anglers’ Laird bar and elsewhere out of town I went. 51.29 THE STAPLE SINGERS – I’ll Take You There – 7″ – Stax – 1972 They never let on where exactly ‘there’ is but with their gospel background we can maybe guess. Good luck with it. 55.30 CARLA THOMAS – Things Ya Make Me Do (Summer Mix) – 12″ – Ruff Justice – 1994 Not the ’60s Stax label Carla Thomas but it’d be nice to think this CT’s parents had that lady in mind when naming this lady. What might have been tagged ‘street soul’… and possibly out of Manchester, UK. 59.06 THOMAS DYBDAHL – All’s Not Lost – That Great October Sound, CD only – Checkpoint Charlie Audio Productions – 2001 Delicate sounds from Norway. 01.04.06 PURESSENCE – Don’t Know Any Better – 7″ – Reaction Records – 2008 James Mudriczki’s vocal… 01.07.22 DAVID SYLVIAN – Nostalgia – Brilliant Trees, LP – Virgin – 1994 Post Japan, his first solo album making its mark in fine style. It was unlikely to do otherwise. 01.12.57 JOY DIVISION – Insight – The Peel Sessions, 12″EP – Strange Fruit – 1986 Peel sessions sort of mimicked a live gig recording at its crystal clear best… this one included. 01.16.50 SIOUXSIE and THE BANSHEES – Christine (Warner Chappell demo) – Kaleidoscope, CD only – Polydor – 2006 With everyone and everything here ‘battling’ to be the most understated – and with it all quite possibly recorded in a rehearsal room, on the likes of (say) a 4-track Portastudio – this is as demo’ish as a major act’s demo could sound back then. 01.19.32 THE FLAMINGOS – Shone Like The Sun #3 (unreleased demo) – 1984 With Cliff (Peacock) in Scott Walker-mode there were a few versions of this tune and to these ears it sounds even better now than it did back then. In effect the above might have doubled as my 27th birthday party and Shone Like The Sun was very likely on the Flamingos set list. 01.24.12 THE WAKE – Make You Understand – Here Comes Everybody, CD only comp – Factory Benelux – 2015 Recorded for a Feb ’84 BBC Radio 1 session for David/Kid Jensen and played live but the former only ever surfaced on the above. Stephen, Mac, Carolyn and Caesar: Winkles, Bedford, 13.11.83 Photo credit/copyright: Dec Hickey 01.26.33 LITTLE NEMO – Bed In Summer – La Cassette Froide, split cassette (with Rain Culture) – self released – 1986 Not the first European band in the mid to late ’80s to have sounded as if heavily influenced by UK bands of the early ’80s and with a track only to be found on this cassette. I won’t be acquiring one any time soon. 01.30.27 THE STRANGLERS – London Lady – 7″ – United Artists – 1977 Yep, Jean-Jacques Burnel with a lyric or two (well, one in particular) that we youth most probably laughed through back in the day but now would maybe slightly wince at. The times… 01.32.52 ELVIS COSTELLO – (I Don’t Want To Go To) Chelsea – 7″ – Radar – 1978 I had a brief moment with Declan’s singles around this time… and you had to admire the balls of a musician who wanted to strike out as an Elvis. 01.35.53 THE SUB ENSEMBLE – Faster Than The Sun (Domu Remix) – Download only – 2008 Very short-lived crew aided and abetted here by acclaimed Bedford-based (then, anyway) DJ, producer, remixer, Domu. 01.41.01 JAZZ THE GLASS – 16 Seconds – Download only, Soundcloud – 2019 A 41 Rooms regular, with another winner. Dave reminded me it uses a sample from a US boy band. I think it was a white label 12″ with anonymous writing (just initials?), that I took a punt on at no more than 20p. 01.44.47 FPI PROJECT – Come On (And Do It) (TC Funky Mix) – 12″ – Synthetic Records – 1993 ‘Tremendous funky Italian offering as ever from those talented members of Ital’s most consistent band. Chocca full of good alternative mixes, including a wicked guitar ladened TC Funky mix… ‘ – Kenny Grogan, Mixmag Update, 28.4.93 ‘Everything you love/hate about Italian records in double helpings. Very FPI Project but bang on time with its riffing flamenco-style guitar and a bundle of irresistibly funked up mixes firm Mother-man Lee Fisher, which include a wonderful reinvention of the bouncy original into a big booming beast of a track‘. Matthew Cole, Record Mirror (Music Week), 10.7.93 ‘Girl chanted powerful Hamilton Bohannon-ish happy party pounder’s original Gypsy Kings-like guitars strummed 125bpm Official, 125.2bpm Gipsy, TC 1993 wukka-wukked 125.2bpm TC Funky Mixes, new sax squawked jerkily percussive building 124.9bpm Mothers At Work Remix and Dub‘. – James Hamilton, Record Mirror (Music Week), 7.8.93 As mentioned on the show, a one and a bit trick pony but sometimes a funky break and some vocal snippets is all you need for some head nodding bizniz. 01.49.36 CHEZ DAMIER & CO-INSIDE – Give A Little Love (Made In Detroit Mix) – The United States EP, 12″ – t:ime – 1993 ‘Nottingham’s Sine boys have always (worn) worthier US influences on their sleeves. This time they make a more permanent connection with two excellent transatlantic collaborations. Their Made In Detroit Mix of Give A Little Love by Chez Damier & Co-Inside is a supremely cool organ-washed garage groove with the repeated title line drifting in and out of the mix. It becomes less mellow and more dubby as it progresses…‘ – Andy Beevers, Record Mirror (Music Week), 4.9.93 And yet another tune with a minimal use of different lyrics… and here you’re not getting the full nine minutes they’re spread over on the 12″. Still, jaunty US house with a bit of a UK ’90s garage’y feel… and I think I edited out some frogs sounds. 01.53.15 THE REESE PROJECT – The Colour of Love (Groove Corporation Trance Mix) * – 12″ – Network – 1992 ‘Even by his own standards, Kevin Saunderson is having a good year. With Inner City firmly re-established as one of the world’s leading dance acts, he now takes the limelight under his alter-ego for what will be one of the biggest tunes of the year. The Deep Reese mix (featured on the Network ‘Elixir Vitae’ double pack extravaganza that some might say is their apology for KWS) is still the one for me. The coffee table intro soaring into a menacing groove with the hookiest of vocal samples… bliss. But wait, let us not forget Groove (aka Electribe 101) Corporation’s four mixes full of true British grit and trance appeal… ‘ – Dave Seaman ****1/2 Mixmag Update, July 9, ’92. ‘Kevin ‘Master Reese’ Saunderson’s powerful Rachel Kapp wailed Club Chart topper is now out on one single in brilliant swimming bass pulsed wriggly warbling 121.6bpm Magic Juan Atkins Mix, gospelishly started hypnotically chugging (0-)123.4bpm Deep Reese Mix, piano plonked 121.6-121.5bpm Underground Resistance Mix, repetitively stuttered Kym Sims-ish 122-122.1bpm MK Deep Dub, good insistently rolling 114.7-114.8bpm Groove Corporation Trance Mix and bass bubbled blippy 114.9-114.8bpm Groove Corporation Wobble Dub, while the first of the separate promos had its throbbing somehow then steady 115bpm Vocal (Trance Mix) and 115-114.9bpm Acid Revival (Wobble Dub), plus alternative swirlingly chugging 115bpm Plae Blue Mix and Instrumental Groove Corporation 021 Remixes‘. – James Hamilton, Record Mirror (Music Week), 1.8.92 Slinky Saunderson… and albeit it the same theme, a thousand miles from Terry Callier’s What Colour Is Love in every other way. Show 148 should surface here Feb 1. Dec x The post Post Punk Plus Podcast Playlist 147 – Original upload 4.1.26 appeared first on 41Rooms.

*Get Shaan's 4 money rules that took him from broke to $25M by 30:* https://clickhubspot.com/wrg Episode 777: Shaan Puri ( ⁠https://x.com/ShaanVP⁠ ) talks to Chris Camillo ( https://x.com/ChrisCamillo ) about how he turned $20K into $60M using social arbitrage investing.  — Show Notes: (0:00) Intro (1:00) Turning $20K to $60M (5:30) Garage sale arbitrage (12:36) Observational investing (14:33) Bet: Beacon Roof (19:03) Bet: E.l.f (22:04) Trending on Twitter (29:00) Ticker Tags (31:55) Bet: Sphere in Las Vegas (36:48) Chris's first million (40:34) My biggest mistake (43:42) Bet: Palantir (46:58) Drawing down 40% of my net worth (51:49) $30M in one year (57:39) 2026 picks: Bloom Energy, Palantir, NVIDIA (1:02:06) Should regular people do this? (1:13:45) Bet: Private airfaire — Links: • Ticker Tags - https://ticker-tags.com/  • Dumb Money Live - https://www.youtube.com/@DumbMoneyLive  • Unknown Market Wizards - https://www.amazon.com/Market-Wizards-traders-youve-never/dp/0857198696  • Bloom -  https://www.bloomenergy.com/  — Check Out Shaan's Stuff: • Shaan's weekly email - https://www.shaanpuri.com  • Visit https://www.somewhere.com/mfm to hire worldwide talent like Shaan and get $500 off for being an MFM listener. Hire developers, assistants, marketing pros, sales teams and more for 80% less than US equivalents. • Mercury - Need a bank for your company? Go check out Mercury (mercury.com). Shaan uses it for all of his companies! Mercury is a financial technology company, not an FDIC-insured bank. Banking services provided by Choice Financial Group, Column, N.A., and Evolve Bank & Trust, Members FDIC — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com • Hampton Wealth Survey - https://joinhampton.com/wealth • Sam's List - http://samslist.co/ My First Million is a HubSpot Original Podcast // Brought to you by HubSpot Media // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano //

por Yaiza Santos Después de reconvenir a Santos por andar cantando públicamente en otros foros, se alegró de que los reyes de España fueran a ver Filosofía mundana de don Javier Gomá, y no se resistió a leer una frase de Byung-Chul Han para mostrar el estado de los asuntos filosóficos: «Las series gustan tanto porque responden al hábito de la percepción serial». Sin dilación, pasó al burning paper, que concluyó preguntándose si la causa de la desigualdad en el mercado laboral, de la segregación de género y de todas esas cosas contra las que luchan las feministas no responderá en realidad a algo simple y terrible: querer enamorar. Pigget lo llevó de Putin a Trump y esa publicación lamentable tras el asesinato del director Rob Reiner y su mujer presuntamente a manos del hijo de ambos. Bien dijo Iñaki Ellakuria: ¡tanto que se habló de la salud mental de Biden! Un hombre que escribió ese tuit no es alguien que tenga la cabeza en su sitio. Pero lo que verdaderamente quería él contar hoy eran las 52 cosas que Tom Whitwell aprendió en 2025. Algunas tan extraordinarias como que en el Reino Unido se podría evitar pagar impuestos por un edificio de oficinas vacío llenándolo de cubetas de plástico con caracoles y lechugas, porque el edificio pasaría a ser legalmente una granja y podría quedar exento de impuestos según la ley. ¡Ah, cómo los periódicos han renunciado a la amenidad!, exclamó. Entre sus favoritas: que las muertes mundiales por contaminación del aire están cayendo rápidamente, que una epidemia de asesinos en serie en Estados Unidos podría haber sido causada por las emanaciones de plomo de coches y fábricas y la ley de Gall: un sistema complejo que funciona evoluciona siempre a partir de un sistema simple que funciona. Por lo demás, el elemento número 40 de la lista ya figura entre sus aforismos favoritos: «Escribir es una manera de escapar de la configuración por defecto de la mente» Y fue así que Espada yiró. Bibliografía Lena Hipp, Sandra Leumann y Pia Schober, «Partnership penalties for working in gender-atypical occupations? Observational and experimental evidence from Germany», preprint See omnystudio.com/listener for privacy information.

Blogpost asociado  https://ecctrainings.com/te-atreverias-a-dar-tromboliticos-prehospitalarios-para-embolia-pulmonar-lo-que-revela-el-nuevo-estudio-y-como-prepararte-con-acls/" Referencia del estudio original: Harjola, J., Holmström, P., Sane, M., Hartikainen, J., & Harjola, V.-P. (2025). Prehospital fibrinolysis in high-risk pulmonary embolism – Observational data on clinical picture and outcome. Prehospital Emergency Care, 29(7), 1–8. https://doi.org/10.1080/10903127.2025.2582671 Recordatorio rápido: embolia pulmonar de alto riesgo Definición sencilla: EP de alto riesgo / masiva → se manifiesta como shock obstructivo o paro cardiaco. Fisiopatología en pocas palabras: Trombo grande en circulación pulmonar → aumento de poscarga del ventrículo derecho → falla del VD → colapso hemodinámico. Por qué es tan letal: Deterioro muy rápido, ventana terapéutica corta. Frecuentemente se presenta como paro fuera del hospital. Conectar con ACLS: La EP masiva está dentro de las "T" (tromboembolismo) en las causas reversibles del paro. Las guías ACLS contemplan el uso de trombolíticos cuando se sospecha fuertemente EP como causa del paro. ¿Cómo se ve clínicamente un paciente con EP de alto riesgo? Disnea súbita, dolor torácico, síncope, hipotensión, antecedentes de riesgo trombótico. Resumen del estudio de Harjola et al. Objetivo principal del estudio Explorar supervivencia y complicaciones hemorrágicas del uso de trombolíticos prehospitalarios para embolia pulmonar de alto riesgo. Diseño Datos de EMS del área metropolitana de Helsinki + hospital universitario. Periodo aproximado: 2007–2019. Inclusión: Pacientes con EP de alto riesgo sospechada clínicamente. Tratados con fibrinolisis intravenosa prehospitalaria. Diagnóstico de EP confirmado posteriormente por imagen o autopsia. Grupo comparador: Pacientes con EP de alto riesgo que no recibieron fibrinólisis prehospitalaria. Resultados clave Total de pacientes con EP de alto riesgo: 60. Grupo con trombolíticos prehospitalarios para embolia pulmonar: n = 23. 44% mujeres. Edad media: alrededor de 57 años. 74% se presentaron en paro cardiaco. 26% en shock obstructivo. Mortalidad: Mortalidad prehospitalaria aproximada: 35%. Mortalidad intrahospitalaria: alrededor de 27% de los que llegaron vivos. Mortalidad total combinada: cerca de 52%. Todas las muertes en este grupo fueron en pacientes que llegaron en paro cardiaco. Complicaciones: 2 pacientes con sangrado mayor. Ningún sangrado fatal. Supervivencia a 12 meses: Los pacientes trombolizados que salieron vivos del hospital seguían vivos a los 12 meses. Grupo sin trombolisis prehospitalaria: n = 37. Más añosos (edad media cercana a 72 años). Mayor proporción de paro cardiaco. Mortalidad a 12 meses más alta (≈ 76%, tendencia, p alrededor de 0.06). Comentario para desarrollar: Es un estudio observacional, con n pequeño, no podemos concluir causalidad, pero sí hay "señales" interesantes de posible beneficio. ¿Qué nos dice realmente este estudio? Mensajes principales La EP de alto riesgo fuera del hospital tiene una mortalidad muy alta aun con intervenciones agresivas. En este contexto crítico, los trombolíticos prehospitalarios para embolia pulmonar: Parecen relativamente seguros (pocas hemorragias mayores, ninguna fatal). Podrían ofrecer un beneficio en supervivencia, especialmente en pacientes seleccionados. Limitaciones para mencionar Serie de casos; no es ensayo aleatorizado. Número pequeño de pacientes trombolizados. Posible sesgo de selección: Pacientes más jóvenes y potencialmente con menos comorbilidades recibieron trombólisis. No responde preguntas como: Detalle exacto del protocolo. Diferencias entre equipos. Tiempos exactos desde el colapso hasta la trombólisis. Idea clave: No es un "permiso" para trombolizar a todo el mundo, pero sí una invitación seria a considerar que, en EP de alto riesgo, la inacción también tiene un costo muy alto. El reto práctico: decidir trombolisis en el campo Barreras en la vida real Diagnóstico presuntivo sin imagen: Dependemos de clínica, antecedentes, ECG, quizás eco focal. Miedo al sangrado: Especialmente hemorragia intracraneal. Falta de protocolos claros: Muchos sistemas de EMS no contemplan todavía trombolíticos prehospitalarios para embolia pulmonar. Falta de entrenamiento específico: No todos se sienten cómodos con indicaciones, contraindicaciones, dosis. Cómo ayuda ACLS aquí ACLS bien aprendido: Te obliga a pensar en H y T, no solo en adrenalina y ciclos. Te muestra dónde se colocan los trombolíticos prehospitalarios para embolia pulmonar dentro del algoritmo. Te entrena para liderar un equipo y tomar decisiones bajo presión. Conectar con los cursos de ECCtrainings: En nuestros ACLS discutimos escenarios de paro por EP masiva. Practicamos cómo tomar la decisión de administrar o no trombolítico. Simulamos la comunicación con el hospital receptor después de trombólisis. Caso clínico narrado Propuesta de caso Varón de 48 años. Disnea súbita, dolor torácico, antecedente de inmovilidad o TVP reciente. Hipotenso, taquicárdico, saturación baja, signos de shock. En la ambulancia entra en PEA. El equipo evalúa H y T → EP masiva muy probable. Protocolo local permite trombolíticos prehospitalarios para embolia pulmonar: Se administra el medicamento durante la RCP. Después de varios ciclos recupera pulso. Llega vivo al hospital, se confirma EP por imagen y sobrevive. Puntos a resaltar Valor de: reconocer el patrón clínico, tener protocolos, estar entrenado en ACLS. Conectar con la serie de Helsinki: "Son justamente este tipo de pacientes los que aparecen en la serie: altísimo riesgo, pero con posibilidad real de supervivencia si somos agresivos." Cómo prepararte tú y tu sistema Pasos sugeridos para líderes, educadores y clínicos de EMS Revisar la evidencia Usar este estudio como punto de partida para la discusión sobre trombolíticos prehospitalarios para embolia pulmonar. Evaluar la realidad local ¿Disponibilidad del medicamento? ¿Quién puede prescribir y administrar? ¿Qué soporte hospitalario hay (UCI, hemodinamia, ECMO)? Desarrollar protocolos claros Criterios de inclusión y exclusión. Algoritmo que integre ACLS y trombólisis. Entrenamiento formal No basta con escribir el protocolo; hay que entrenarlo en simulación. Cursos ACLS con escenarios específicos de EP. Simulaciones y revisión de casos Simulacros periódicos con roles definidos. Morbimortalidad / debriefing de casos reales o simulados. Comunidad: seguir la conversación en ECCnetwork ECCnetwork: Comunidad en línea para profesionales de emergencias, cuidado crítico, medicina táctica, etc. Espacios para discutir artículos, casos, protocolos, dudas. Invitar a que compartan: ¿Su sistema consideraría trombolíticos prehospitalarios para embolia pulmonar? ¿Qué barreras ven? ¿Experiencias que puedan comentar? Recursos adicionales y blogpost Recordar el blogpost: URL:

Dana Aravich joins host J.J. Mowder-Tinney for a deep dive into one of rehab's most perplexing challenges: spatial neglect. Drawing on her clinical experience and research, Dana and J.J. unpack how this complex attention disorder impacts function and why it's so often mistaken for a visual field deficit. Together, they explore practical, evidence-informed strategies for assessment, intervention planning, and team-based decision-making. Whether you're confident or still uncertain in managing neglect, this episode offers new ways to think about what truly guides your approach.Learning ObjectivesAnalyze the evidence around the complexity and clinical implications of spatial neglect in individuals recovering from stroke and brain injuryApply evidence-based, practical, and actionable strategies to address the identification, evaluation, and tailored intervention planning for clients experiencing spatial neglectSolve patient case scenarios involving differential diagnosis and intervention planning for spatial neglect versus visual field deficits, incorporating contextual factors such as driving safety and functional independenceTimestamps(00:00:00) Welcome(00:00:05) Introduction(00:02:44) Understanding spatial neglect(00:04:36) Types of neglect(00:09:43) Evaluation challenges(00:10:40) Evidence-based assessment tools(00:15:40) The 292 assessment tools problem(00:22:21) Treatment complexity(00:24:30) Treatment strategies and research(00:26:25) Prism therapy and vision considerations(00:31:03) Screening and differential diagnosis(00:37:30) Observational insights and self-awareness(00:41:35) Self-reflection and chronic stages(00:44:32) Severe cases and poor arousal(00:47:48) Meaningful motivation(00:49:27) Family education and involvement(00:51:49) Key takeaways(00:52:55) Closing remarksNeuro Navigators is brought to you by Medbridge. If you'd like to earn continuing education credit for listening to this episode and access bonus takeaway handouts, log in to your Medbridge account and navigate to the course where you'll find accreditation details. If applicable, complete the post-course assessment and survey to be eligible for credit. The takeaway handout on Medbridge gives you the key points mentioned in this episode, along with additional resources you can implement into your practice right away.To hear more episodes of Neuro Naviagators, visit ⁠⁠⁠⁠⁠⁠⁠⁠https://www.medbridge.com/neuro-navigators⁠⁠⁠⁠⁠⁠⁠⁠If you'd like to subscribe to Medbridge, visit ⁠⁠⁠⁠⁠⁠⁠⁠https://www.medbridge.com/pricing/⁠⁠⁠⁠⁠⁠⁠⁠IG: ⁠⁠⁠⁠⁠https://www.instagram.com/medbridgeteam/

If you felt whiplash reading recent headlines about estrogen and perimenopause—you're not alone.At the 2025 Menopause Society Annual Meeting, a research poster analyzing data from more than 120 million women unexpectedly ignited a media firestorm. News outlets quickly framed the findings as proof that starting estrogen in perimenopause prevents breast cancer, heart attacks, and stroke—sparking viral conversations that went far beyond what the data can actually support.In this episode of Sky Women's Health, Dr. Carolyn Moyers is joined by Dr. Rachel Pope, MD, gynecologist, menopause specialist, and mentor on the research team behind the poster, to slow the conversation down and bring clarity back to the science.Together, we unpack what the study really showed, what was lost in translation, and how women should interpret this information when making decisions about hormone therapy.Why This Study Caught Fire* The study used a massive electronic health record database of over 120 million patient records* It compared women who started estrogen: * during perimenopause * after menopause * or never used estrogen* It examined rates of breast cancer, heart attack, and stroke* Media headlines quickly implied causation—despite this being a retrospective, observational studyWhat the Data Actually Showed* Women who used estrogen during perimenopause (within 10 years before menopause) did not have higher rates of breast cancer, heart attack, or stroke compared with the other groups* These findings support the idea that earlier initiation may be safe and potentially beneficial—but do not prove protection or prevention* The results align with the broader timing hypothesis of hormone therapy, but do not settle the debateCritical Limitations That Didn't Make the Headlines* This study relied on diagnosis codes, not individual chart review* It did not analyze: * type of estrogen * dose or route * type of progestin* There was no breakdown by race, ethnicity, or other demographic factors* Because perimenopausal women are younger, some conditions (like breast cancer or cardiovascular disease) may simply not have occurred yet during the study's timeframe* Like all retrospective studies, it cannot determine cause and effectWhy This Still Matters for Women* Many women experience significant symptoms during perimenopause, often years before their final period* Hormone therapy can be life-changing for symptoms and quality of life* This study helps normalize thoughtful, earlier conversations—but it does not replace individualized medical decision-making* Observational data like this helps generate hypotheses and funding for future prospective trials, which we still urgently needThe Real TakeawayThis study doesn't mean everyone should start estrogen in perimenopause—and it doesn't mean estrogen prevents disease. What it does mean is that earlier use appears reassuringly safe in this dataset, and that women deserve nuanced, evidence-based counseling rather than fear-driven or headline-driven decisions.If you're navigating perimenopause, the most important factors remain:* your symptoms* your health history* your goals* your personal risk profile* shared decision-making with a menopause-informed clinicianResources Mentioned* The Menopause Society provider directory at Menopause.org for finding evidence-based menopause care

“Jesus is coming” signs, brain rot, and the Giggle of God — yeah, we're starting there.In this one, I'm ranting about religious childhood trauma in the funniest way I know how — youth pastors whispering “Lord, come inside all of us,” yard signs that say “Jesus is coming,” and how wearing a cross is basically spiritual incognito mode plus a VPN for your sins. Observational humor meets absolute blasphemous brain rot.Then I accidentally invent my new alter ego: “God's Giggler.” I paint this whole scene of me backstage at an Austin comedy club with a tiny cigar, lightning in the ceiling, a kid in a Peaky Blinders hat holding a bucket, and me declaring, “God's feeling funny tonight.” This is pure stand-up storytelling energy from an Austin comedian who's maybe taken pre-workout for his imagination.From there we slide hard into funny dad podcast mode: first-year parenting as a full-blown stress test. Baby breath-holding, fevers, rashes, thinking “Welp, guess my baby's dead now” every 10 minutes, and realizing other parents were right when they said, “You are not busy until you have kids.” If you like parenting humor that's way too honest, you're home.I talk about how having a kid nuked my ability to waste time on dumb arguments, turned my 2-hour gym sessions into 45-minute efficiency missions, and forced me to kill a bunch of ego just to survive. Less stewing in drama, more doing reps — in the garage and in life.We also get into screen addiction and babies: my daughter going full Gollum over the phone, why we basically had to break up with FaceTime, and my fantasy of going full flip-phone while still needing Venmo, maps, banking, Amazon, and to run an entire career as a new comedian in 2025.It ends kinda wholesome: how the holidays hit different now, why small-kid years are this fleeting magical window, and how I'm trying to stop living for “the next thing” and actually enjoy the mess I'm in. If you like relatable comedy, funny life stories, and listening to an Austin comedian overthink fatherhood in real time, this is it.Come see a show in Austin, tell a friend about the pod, and rate the pod unless you're a hater.#AustinComedy #FunnyPodcast #DadLife

Send us a textMethods & challenges of establishing causal relationships in health research, emphasizing epidemiology, randomized trials, and genetic approaches.Topics:Epidemiology: Studies disease influences using observational designs like case-control and prospective cohorts, plus trials, to identify patterns and test hypotheses.Hierarchy of evidence critique: Rejects rigid pyramids favoring RCTs, as all studies can be biased; advocates triangulation integrating varied data types for robust conclusions.RCT strengths & weaknesses: Randomization balances confounders, but issues like poor blinding, attrition, or subversion can undermine results; large samples may yield spurious precision if biased.Confounding & reverse causation: Examples include yellow fingers and lung cancer (both from smoking) or early atherosclerosis inflating CRP-disease links; hard to fully control statistically.Nutrition epidemiology: Observational studies often overstate benefits (e.g., vitamin E for heart disease), leading to failed trials; incentives favor new findings over revisiting errors.Mendelian randomization: Uses genetic variants as proxies for exposures (e.g., ALDH2 for alcohol metabolism) to mimic randomization; reveals no heart benefits from alcohol, unlike observational data.Negative controls: Tests implausible outcomes (e.g., smoking and murder) or exposures (e.g., paternal smoking in pregnancy) to check for confounding artifacts.Evidence triangulation: Combines diverse studies with different biases (e.g., cross-cultural comparisons) for causality; applied to dismiss HDL-raising drugs despite initial promise.Practical Takeaways:Scrutinize health claims by checking for negative controls or variety in evidence sources to avoid mistaking correlation for causation.For personal decisions like alcohol intake, consider genetic studies showing risks at all levels, and aim for moderation or abstinence based on overall evidence.When evaluating supplements or diets, prioritize trials over observational data, and question media hype that ignores confounding factors.About the guest: Dr. George Davey Smith, MD, DSc is a professor of clinical epidemiology at the University of Bristol and director of the MRC Integrative Epidemiology Unit.*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Observational Cinematic Compulsion Disorder, or OCCD, is a common behavioral condition characterized by involuntary ocular fixation on a neighbor's in-flight audiovisual LCD display, even in the absence of accompanying auditory stimuli. Patients with OCCD exhibit vastly impaired concentration filtration, resulting in reflexive visual tracking of narrative cinematic sequences presented on adjacent personal screens during commercial air travel. The disorder is frequently associated with heightened situational distractibility, transient dissociative drift, and a paradoxical increase in attentional salience toward media not voluntarily selected by the patient. Management of OCCD involves admission to a 19th-century gothic asylum in upstate New York, with current clinical guidelines emphasizing electroconvulsive therapy administered on a daily basis, leading to a positive outcome of preemptive engagement with self-selected entertainment to mitigate cross-screen visual intrusion. This episode is brought to you by BetterHelp. Give online therapy and get on your way to being your best self at https://Betterhelp.com/BALD For a limited time get 40% off your first box PLUS get a free item in every box for life, by using promo code BALD at: https://Hungryroot.com/BALD To get simple, online access to personalized, affordable care for ED, Hair Loss, Weight Loss, and more, go to: https://Hims.com/BALD Find out why Nutrafol is the best-selling hair growth supplement brand by using promo code BALD at: https://Nutrafol.com The Holidays are here! Don't miss out on early Black Friday deals at Wayfair! Hurry, as the sale ends December 7th! For up to 70%off, head to: https://Wayfair.com Follow Trixie: @TrixieMattel Follow Katya: @Katya_Zamo To watch the podcast on YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://bit.ly/TrixieKatyaYT⁠ To check out our official YouTube Clips Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/TrixieAndKatyaClipYT⁠ Don't forget to follow the podcast for free wherever you're listening or by using this link: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/thebaldandthebeautifulpodcast⁠ If you want to support the show, and get all the episodes ad-free go to: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://thebaldandthebeautiful.supercast.com⁠ To check out future Live Podcast Shows, go to: ⁠⁠https://trixieandkatya.com/#tour⁠ To check out the Trixie Motel in Palm Springs, CA: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.trixiemotel.com⁠ Listen Anywhere! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://bit.ly/thebaldandthebeautifulpodcast⁠ Follow Trixie: Official Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.trixiemattel.com⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@trixie⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/trixiemattel⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/trixiemattel⁠ Twitter (X): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/trixiemattel⁠   Follow Katya: Official Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.welovekatya.com⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@katya_zamo⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/welovekatya⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/katya_zamo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Twitter (X): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/katya_zamo⁠   #TrixieMattel #KatyaZamo #BaldBeautiful Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of the Jack Westin MCAT Podcast, Mike and Molly break down one of the highest-yield (and most commonly missed) topics in the entire Psych/Soc section:→ Experimental vs. Observational research→ When you can (and CANNOT) conclude causality→ Cross-sectional vs. longitudinal→ Cohort vs. case-control vs. case studies→ Prospective vs. retrospective→ Validity vs. reliability (internal vs. external + the dartboard analogy)→ Real AAMC examples (including the cocaine exposure passage)→ Classic studies: Phineas Gage, H.M., Milgram, Little Albert, Asch, Bobo doll, and moreIf you've ever picked the “causes” answer choice on an observational study and gotten wrecked, this episode is for you. Skill 3 (reasoning about research design & execution) shows up in EVERY section, but Psych/Soc is where it can make or break your score.Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!

Level up your MCAT Psych/Soc with the part 2 of masterclass on learning & conditioning, the way AAMC now tests it. Mike & Molly cover the exact strategies to read passages like CARS, not a terms quiz.What you'll learnClassical conditioning: US/UR, CS/CR, generalization, discrimination, extinction & spontaneous recoveryOperant conditioning: reinforcement vs punishment, positive vs negative (with real-life examples)Reinforcement schedules: fixed/variable × ratio/interval (why VR resists extinction)Observational learning: Bobo doll, mirror neurons, media effectsNon-associative learning: habituation, sensitization, dishabituation, desensitizationIf this helped, subscribe and catch next week's Data Interpretation Deep Dive.Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!

“It's 5pm and your Consultant (attending) has headed off home. A patient arrives in the resuscitation room blood spurting from a stab wound in the armpit. Join Roisin – a junior Major Trauma fellow, Prash – a surgical trainee, Max – a senior trauma surgery fellow, and Chris – a Consultant trauma surgeon, as we talk through decision making from point of injury to aftercare in this challenging trauma surgical case”. • Hosts: Bulleted list of host names, including title, institution, & social media handles if indicated 1.     Mr Prashanth Ramaraj. General Surgery trainee, Edinburgh rotation. @LonTraumaSchool 2.     Dr Roisin Kelly. Major Trauma Junior Clinical Fellow, Royal London Hospital.  3.     Mr Max Marsden. Resuscitative Major Trauma Fellow, Royal London Hospital. @maxmarsden83 4.     Mr Christopher Aylwin. Consultant Trauma & Vascular Surgeon and Co-Programme Director MSc Trauma Sciences at Queen Mary University of London. @cjaylwin • Learning objectives: Bulleted list of learning objectives. A)    To become familiar with prehospital methods of haemorrhage control in penetrating junctional injuries. B)     To recognise the benefits of prehospital blood product resuscitation in some trauma patients. C)     To follow the nuanced decision making in decision for CT scan in a patient with a penetrating junctional injury. D)    To describe the possible approaches to the axillary artery in the context of resuscitative trauma surgery. E)     To become familiar with decision making around intraoperative systemic anticoagulation in the trauma patient. F)     To become familiar with decision making on type of repair and graft material in vascular trauma. G)    To recognise the team approach in holistic trauma care through the continuum of trauma care. • References: Bulleted list of references with PubMed links. 1.    Perkins Z. et al., 2012. Epidemiology and Outcome of Vascular Trauma at a British Major Trauma Centre. EJVES. https://www.ejves.com/article/S1078-5884(12)00337-1/fulltext 2.    Ramaraj P., et al. 2025. The anatomical distribution of penetrating junctional injuries and their resource implications: A retrospective cohort study. Injury. https://www.injuryjournal.com/article/S0020-1383(24)00771-X/ 3.    Smith, S., et al. 2019. The effectiveness of junctional tourniquets: A systematic review and meta-analysis. J Trauma Acute Care Surg. https://journals.lww.com/jtrauma/abstract/2019/03000/the_effectiveness_of_junctional_tourniquets__a.20.aspx 4.    Rijnhout TWH, et al. 2019. Is prehospital blood transfusion effective and safe in haemorrhagic trauma patients? A systematic review and meta-analysis. Injury. https://www.injuryjournal.com/article/S0020-1383(19)30133-0/ 5.    Davenport R, et al. 2023. Prehospital blood transfusion: Can we agree on a standardised approach? Injury. https://www.injuryjournal.com/article/S0020-1383(22)00915-9. 6.    Borgman MA., et al. 2007. The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital. J Trauma Acute Care Surg. https://journals.lww.com/jtrauma/fulltext/2007/10000/the_ratio_of_blood_products_transfused_affects.13.aspx 7.    Holcomb JB., et al. 2013. The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study. Comparative Effectiveness of a Time-Varying Treatment With Competing Risks. JAMA Surgery. https://jamanetwork.com/journals/jamasurgery/fullarticle/1379768 8.    Holcomb JB, et al. 2015. Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma. The PROPPR Randomized Clinical Trial. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2107789 9.    Davenport R., et al. 2023. Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury. The CRYOSTAT-2 Randomized Clinical Trial. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2810756 10.   Baksaas-Aasen K., et al. 2020. Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial. ICM. https://link.springer.com/article/10.1007/s00134-020-06266-1 11. Wahlgren CM., et al. 2025. European Society for Vascular Surgery (ESVS) 2025 Clinical Practice Guidelines on the Management of Vascular Trauma. EJVES. https://esvs.org/wp-content/uploads/2025/01/2025-Vascular-Trauma-Guidelines.pdf 12. Khan S., et al. 2020. A meta-analysis on anticoagulation after vascular trauma. Eur J Traum Emerg Surg. https://link.springer.com/article/10.1007/s00068-020-01321-4 13. Stonko DP., et al. 2022. Postoperative antiplatelet and/or anticoagulation use does not impact complication or reintervention rates after vein repair of arterial injury: A PROOVIT study. Vascular. https://journals.sagepub.com/doi/10.1177/17085381221082371?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

The Elephant in the Universe: 100-year search for dark matter Author: Govert Schilling Theoretical Stability and Observational Proof of Dark Matter Halos Headline: Galaxies Need Invisible Halos: Ostriker and Rubin Provide Evidence In the late 1960s, theorist Jeremiah Ostriker calculated that a flattened galaxy like the Milky Way could not remain stable without a large, spherical "halo" of unseen matter surrounding it, providing a theoretical basis for dark matter. This theoretical need was then powerfully confirmed by the observational work of American astronomer Vera Rubin and her colleague Kent Ford throughout the 1970s. Studying distant galaxies, including Andromeda, they discovered that stars on the outer edges rotated at unexpectedly high, constant velocities, rather than slowing down as predicted. This "flattening the curve" of rotational velocities offered the first concrete proof for the existence of dark matter, whose gravity was necessary to prevent galaxies from flying apart. 1958

In episode 503 of The Astrology Podcast astrologer Rod Chang joins me to discuss the long and fascinating history of comets in astrology, how astrologers viewed them as omens in ancient times, and creating a new foundation for interpreting them today. While comets are a notable astronomical phenomenon and are famous in legends from ancient times as powerful omens, there has been very little discussion about their meaning or use in modern astrology. Part of the reason for this is that they appear so infrequently, are difficult to calculate, and are not included in most astrology software, which has led to them being largely overlooked by contemporary astrologers. We begin the discussion by exploring the long history of comets in astrology, noting the contrast between the Western tradition and the Chinese tradition. In the West, research into comets was set back for centuries by Aristotle's mistaken belief that they were merely atmospheric phenomena. In the Chinese tradition, however, comets were meticulously documented for thousands of years, where they were often referred to as "broom stars" that could sweep away the old government or indicate the need for reform. This eventually led to a rich history of astrological interpretation, which we are only now beginning to recover and understand. During the course of the episode we talk about what comets are from an astronomical perspective, as well as how their erratic and unpredictable nature became a key part of their astrological interpretation. Traditionally comets were interpreted as omens that signified major disruptions, the death of prominent people, and important turning points in history. Their meaning was often derived from their visual appearance, such as their color or the shape of their tail. While often viewed as negative omens that coincided with natural disasters or the death of rulers, there are also instances where they were interpreted positively. Towards the end of the episode we discuss how contemporary astrologers are now in a much better position to study comets, with new tools that allow us to calculate their positions and go back and research what was happening in the world when major comets appeared in the past. This is a large part of the focus of Rod's new book titled Comets in Astrology, where he identifies some of the most important "Great Comets" in history and documents the events that coincided with their appearance. We hope that this discussion provides a good foundation for a subject that will become an exciting new area of research in astrology in the years to come. Rod's book was just released August 13, and you can get it now: Comets in Astrology on Amazon You can find out more information about Rod on his website: RodChang.com This episode is available in both audio and video versions below. Timestamps 00:00:00 Introduction 00:01:05 Rod's journey into studying comets 00:02:40 Why comets are overlooked in modern astrology 00:07:09 What is a comet? 00:10:04 Short-period vs. long-period comets 00:16:55 Erratic and unpredictable quality of comets 00:19:18 Aristotle's error vs. Chinese documentation 00:24:30 Edmond Halley, Brahe, and Kepler 00:28:58 Recent comets: Pons-Brooks 00:33:52 Decline of astrology hindered comet research 00:36:39 Researching historical comets and mundane events 00:39:01 What defines a “Great Comet” 00:51:04 Chinese “broom stars” and political significance 01:01:06 Comets as omens 01:11:47 Death of prominent people 01:15:02 Mark Twain and Halley's Comet 01:25:52 Observational astronomy 01:36:18 Comet's tail and directionality 01:40:03 Positive interpretations of comets 01:43:27 Setting a foundation for comet research 01:48:11 Rod's upcoming work, website, and classes 01:51:29 Concluding remarks Watch the Video Version of This Episode https://www.youtube.com/watch?v=U-UtgNIRCnY –

00:45 The deepest ecosystem ever discoveredResearchers have dived down to more than 9,000 metres below the surface of the Pacific and discovered surprisingly complex communities of life living in deep ocean trenches. The new research shows an array of animal life that appears to be using methane as a source of energy. The researchers are planning more dives to learn more about this mysterious ecosystem and how these animals can thrive despite the extreme pressure they face.Research Article: Peng et al09:36 Research HighlightsA fossilized leg bone reveals an 11-million-year-old fight between a terror bird and a caiman, plus the anti-ageing secret of ‘immortal' stars.Research Highlight: Rumble in the Miocene: terror bird versus caimanResearch Highlight: ‘Immortal' stars have an elixir of youth: dark matter11:45 How infections could awaken dormant cancerNew research reveals that infection by a respiratory virus has the potential to awaken dormant cancer cells. In mice studies, a team showed that inflammation caused by infection with influenza or SARS-CoV-2 could initiate the awakening of breast cancer cells that had metastasized to the lungs. Observational studies using human health data also showed that a COVID-19 infection was associated with increased risk of lung metastasis and cancer death. While the precise mechanisms are unknown, the team say that understanding the process could help mitigate any risks of cancer progression caused by a viral infection.Research Article: Chia et al.News and Views: Inflammation during viral infection can rouse dormant cancer cells21:45 Will physicists ever agree on quantum mechanics?A survey of more than 1,100 physicists has revealed that there are widely different interpretations of what quantum mechanics means for our understanding or reality. Reporter Lizzie Gibney takes us through the different ideas physicists have and asks if such disagreements even matter.Nature: Physicists disagree wildly on what quantum mechanics says about reality, Nature survey showsSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.