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In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: 5 Ways to Predict Mortality (NO BLOOD TEST REQUIRED). (2:27) Good and bad news for young men. (22:20) Reducing your calories without eating less by going grass-fed. (35:26) Runit is invading America. (40:16) Speaking identity into your children. (45:12) Sal has an athlete on his hands. (49:58) LMNT has single-handedly created this new electrolyte market. (52:49) #ListenerCoaching call #1 – I train hard and feel great, but I don't feel like it's translating to everyday life. What am I missing? (55:29) #ListenerCoaching call #2 – Needing some advice on my current aggressive fat loss and body recomposition journey. (1:07:55) #ListenerCoaching call #3 – What's your typical recommended rest between sets? (1:17:50) #ListenerCoaching call #4 – Needing guidance on my fitness path and seeking advice on training, macros, and whether you offer personal training. (1:25:08) Related Links/Products Mentioned Get Coached by Mind Pump, live! Visit https://www.mplivecaller.com Visit Butcher Box for this month's exclusive Mind Pump offer! ** New users receive their choice of NY Strip, Ribeye, or Filet Mignon in every box for a year. ** Get a free Sample Pack of LMNT's most popular drink mix flavors with any purchase! As always, LMNT offers no-questions-asked refunds on all orders. The 8-count LMNT Sample Pack doubles down on our most popular flavors: Citrus Salt, Raspberry Salt, Watermelon Salt, and Orange Salt (2 stick packs of each flavor): Visit DrinkLMNT.com/MindPump MAPS 15 Symmetry 50% off! ** Code DECEMBER50 at checkout. ** Mind Pump Store Can a 10-second balance test predict longevity? - Harvard Health Sit-to-stand: The simple test that reveals how you're ageing A brief fitness test may predict how long you'll live Push-Ups and Heart Health: What Your Fitness Level Says About Your Risk HANDGRIP DYNAMOMETER Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies 45 Percent of Guys 18-25 Have Never Asked a Girl Out in Person Australian collision sport Runit makes U.S. debut with stops in SoCal Rosenthal Effect: How Expectations Shape Reality Fig and Eagle Visit Luminose by Entera for an exclusive offer for Mind Pump listeners! ** Code MPM at checkout for 10% off their order or 10% off their first month of a subscribe-and-save. ** Mind Pump #2411: How to Know You are Overtrained & Underfed, Why You May Not Feel Low Testosterone, How to Properly Cut & More (Listener Live Coaching) Mind Pump #2690: The NEW DIET Everyone Is Using For Fat Loss Mind Pump #1612: Everything You Need to Know About Sets, Reps & Rest Periods Mind Pump #2759: Progressive Overload, the Secret to Building Muscle and Burning Fat. Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Adam | Relationship Psychology (@attachmentadam) Instagram Scott Donnell (@imscottdonnell) Instagram Mind Pump Fitness Coaching (@mindpumppersonaltraining) Instagram
Ricky Gervais jokes about crime and punishment in his Netflix special, "Mortality".
The Love, Happiness and Success Podcast With Dr. Lisa Marie Bobby
Most people don't realize they're running on autopilot until life forces them to stop. Through the lens of ‘Memento Mori', this episode shows you how living for meaning can help you find direction, improve your overall well-being, and create a purpose-driven life. You'll learn how to use this mindset shift to support your self improvement, reduce your stress, and cultivate happiness right now. I'm joined by Karen Salmansohn, author and mindset coach, for a conversation about living for meaning and finding direction through the lens of Memento Mori. I'm revisiting this episode because its message feels especially relevant right now - how to reduce stress, stay grounded in your mindset, and create a purpose-driven life without giving up your ambition or drive. Rather than being morbid, the Memento Mori mindset offers clarity. It brings you back into the present moment and helps you make more intentional choices about who you are becoming and what truly matters. Together, we explore why traditional to-do lists often leave people feeling busy but unfulfilled, and how shifting toward values-based, identity-driven habits can support greater happiness and emotional well-being. This episode is an invitation to step out of autopilot, reconnect with what matters most, and begin living with more intention starting exactly where you are. As you listen, I invite you to reflect on this question: If your time is limited, what deserves more of your attention right now? Episode Breakdown: 00:00 Welcome to Love, Happiness & Success 00:48 The “funeral question” and how it helps you live with meaning 01:19 Memento Mori and using mortality awareness to find direction 05:29 Karen's wake-up call and the origin of Your To Die For Life 09:13 “Everything that is not given is lost” and the meaning of legacy 14:22 Aristotle on happiness vs pleasure and building a purpose-driven life 21:08 The to-die list, core values, and identity-based habits 30:22 Karen's seven core values and intentional daily choices 38:28 Mortality marbles and a mindset shift that reduces stress 46:31 Dr. Lisa's 9/11 story and choosing a more intentional life If this gives you a desire for more meaning, more clarity, or a different relationship with stress, I want to offer you something supportive. You're invited to schedule a free consultation with me or a trusted member of my team. This is a private, secure space to talk about what's been weighing on you, what you want to feel differently, and what kind of support would truly help you move forward. You'll answer just a few quick questions so we can thoughtfully match you with the right counselor or coach and help you take the next step toward a more intentional, purpose-driven life. xoxo, Dr. Lisa Marie BobbyGrowing Self
Siamo sempre più soli… anche se siamo sempre connessi
Jimmy Carr is back. Jimmy Carr is one of the most recognisable comedians on the planet: world-touring stand-up, TV host, and author - famous for brutal roasts and surgical one-liners. But in this episode, you get the sharper edge and the deeper thinking: why 2026 is going to feel like a turning point and how young men can get control back. Jimmy is one of the most respected comedians in the world: a world-touring stand-up, TV host, and author known for brutal one-liners and zero mercy… but in this episode you get the full range - savage comedy and the deeply human side. We talk about dating, masculinity, porn, cheap dopamine and why so many young men feel stuck - then we go way bigger: AI as a new “god”, the end of old institutions, how podcasts replaced mainstream media, and why politics is entering a genuinely weird new era. And then the episode turns: Jimmy opens up about grief and love - remembering Sean Lock (including the first joke Jimmy ever heard him say, and why he felt like a father figure), the impact of losing his mum Nora, and a beautiful tribute to Janey Godley and what she said about Jimmy behind the scenes. Expect to learn:Why women select for competence and what “safety” really signals.Jimmy's advice to young men: porn, risk, rejection, and building a real life The loneliness trade-off: liver damage vs social isolation How Jimmy thinks about anxiety, discipline, and “life assignment” Sean Lock's legacy — and what it's like to lose someone you built a career beside Grief, funerals, and the difference between resume virtues and eulogy virtues AI, institutions, and why the next decade could get very “interesting”and much, much more.PartnersSlaters Made To Order If you're in UK and you want a suit that fits properly — Slaters Made To Order is the move.Link: https://www.slaters.co.uk/made-to-order?gclsrc=aw.ds&gad_source=1&gad_campaignid=22326051720&gbraid=0AAAAADogE-bVEefnTzse9hLL0ErpEr-jF&gclid=Cj0KCQiAgbnKBhDgARIsAGCDdlckA1RBqnk3kO10XoXEjj-ilOMcplqUquwYMtHBJtNjWRY75T_TcmkaAlhZEALw_wcBNeutonicFor clean focus and productivity support: Neutonic.Use code DAVID for a discount.Link: https://www.neutonic.com?sca_ref=10212353.vP3Eab049B&utm_source=uppromote&utm_medium=affiliate&utm_campaign=26377300:00 — Young Men Are Stuck01:52 — Jimmy's Back: Glasgow Banter04:18 — “Media Diet” & Mental Health07:27 — ADHD, Boundaries & Discipline08:23 — Arenas, Imposter Syndrome, Movies13:46 — Early Comedy Influences16:21 — How You Build Confidence17:32 — First Glasgow Joke (DVD Era)18:52 — Comedy = Friendship20:28 — Why Dark Humour Helps22:16 — Dating: Safety, Competence, Chemistry24:48 — Advice to Young Men: Porn, Games, Asking Girls Out27:09 — Drinking vs Isolation29:28 — Dealing Young People In: Agency Over Empathy31:35 — Trump + Debate vs Deliberation32:28 — Fourth Turning + Class Politics Flip34:31 — Podcasts Replaced Mainstream Media36:52 — “Be Of Service” — Working-Class Agency37:46 — “Woke”, Status & Suicidal Empathy39:19 — Jimmy's Come-Up: Luck + Work Ethic42:29 — Pre-Show Mindset44:32 — Jimmy's Laugh + His Mum47:48 — Sean Lock: First Meeting + Legacy53:54 — Grief, Mortality & Talking To The Dead55:18 — Funerals: Eulogy vs Résumé01:01:31 — AI, God & The Future01:04:26 — Secret Struggles: Dyslexia, Body Image, Work01:07:24 — Pax Americana Ending + The World Shifting01:10:29 — Kids, Legacy & Meaning01:13:18 — Janey Godley TributeInstagram: @davidmcintoshjrPatreon: https://www.patreon.com/c/davidmcintoshjr/aboutSubstack: https://substack.com/@davidmcintoshjr?Merch: https://originstoryclub.co.uk/
CardioNerds (Dr. Colin Blumenthal, Dr. Kelly Arps, and Dr. Natalie Marrero) discuss anti-arrhythmic drugs in the management of atrial fibrillation and atrial flutter with electrophysiologist Dr. Andrew Epstein. We discuss two major classes of anti-arrhythmic drugs, class IC and class III, as well as digoxin. Dr. Epstein explains their mechanisms of action, indications and specific patient populations in which they would be particularly helpful, efficacy, adverse side effects, contraindications, and key drug-drug interactions. We also elaborate on defining clinical trials and their clinical implications. Given the large burden of atrial fibrillation and atrial flutter in our patient population and the high prevalence of anti-arrhythmic drug use, this episode is sure to be applicable to many practicing physicians and trainees. Audio editing by CardioNerds academy intern, Grace Qiu. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Atrial Fibrillation PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Anti-arrhythmic drugs should not be thought of as an alternative to ablation but, instead, should be considered an adjunct to catheter ablation. Class IC anti-arrhythmic drugs, flecainide and propafenone, are highly efficacious for acute cardioversion and a great option for patients with infrequent episodes of AF who do not have a history of ischemic heart disease. Class III anti-arrhythmic drugs like ibutilide, sotalol, and dofetilide, are highly effective for acute conversion; however, they require hospitalization for close monitoring during initiation and dose titration given the risk of prolonged QT. Amiodarone should not be used as a first line agent given its toxicities, prolonged half-life, large volume of distribution, and drug-drug interactions. Dr. Epstein notes that, “All drugs are poisons with a few beneficial side effects,” when highlighting the many adverse side effects of anti-arrhythmic drugs, particularly amiodarone, and the importance of balancing their benefit in rhythm control with their side effect profile. Notes Notes: Notes drafted by Dr. Natalie Marrero. What are the Class IC anti-arrhythmic drugs and what indications exist for their use? Class IC anti-arrhythmic drugs are anti-arrhythmic drugs that work by blocking sodium channels and, thereby, prolonging depolarizing. Class IC anti-arrhythmic drugs include flecainide and propafenone. Class IC anti-arrhythmic drugs are good agents to use in patients that have infrequent episodes of AF and do not want daily dosing as these agents can be used by patients when they feel palpitations and desire acute conversion back to sinus rhythm (“pill in the pocket” approach). What are the adverse consequences and/or contraindications to using a class IC agent? Class IC anti-arrhythmic agents are contraindicated in patients with a history of ischemic heart disease based on increased mortality associated with their use in these patients in the CAST trial. Given the results of the CAST trial, providers should screen annually for ischemia via a functional stress test in patients on these drugs at risk for coronary disease. These drugs can increase 1:1 conduction of atrial flutter and, therefore, require concomitant use of a beta blocker. These agents are generally well-tolerated without any organ toxicities; however, they can precipitate heart failure in patients with cardiomyopathies, cause sinus node depression, and unmask genetic arrythmias such as a Brugada pattern. What are the class III agents and what are indications for their use? Class III agents are drugs that block the potassium channel, prolonging the QT, and include Ibutilide, Sotalol, and Dofetilide. Class III agents can be considered in patients with or without a history of ischemic heart disease that desire effective acute chemical cardioversion and are willing to go to the hospital for close monitoring during dose initiation and titration. Other specific circumstances in which one can use these agents, specifically Ibutilide, are in patients with recurrent atrial fibrillation and Wolf Parkinson White (due to slowed conduction via the accessory pathway). What are the adverse consequences and/or contraindications to using a class III agent? Ibutilide, Sotalol, and Dofetilide prolong the QT and increase the risk of torsade de pointes, which is why they require ECG monitoring in-patient during drug initiation and dose titration. These agents are generally well-tolerated. Sotalol should be avoided or used cautiously in patients with left ventricular dysfunction, while dofetilide can be used and has dose-response beneficial effects in patients with left ventricular dysfunction. Both sotalol and dofetilide are renally cleared with specific creatinine clearance cutoffs (CrCl < 20 for dofetilide and CrCl
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Cardiovascular-Kidney-Metabolic Syndrome-Attributable Mortality in the United States, From 2010 to 2023.
Justin McRoberts, musician, pastor, and author of "It's What You Make of It," shares how confronting death early in life shaped his approach to creativity and faith. Having attended over 20 funerals by age 25, McRoberts explains why understanding mortality is essential to living fully and why the cultural narrative of imperviousness keeps people from taking creative risks. He explores how opportunities—not rigid plans—defined his multi-hyphenate career, why narrative holds human lives together, and how we're taught that art is something you earn after being responsible to the system. McRoberts makes the case for flipping that script: using your gifts now, taking financial and social risks, and approaching life as something to give away rather than protect. This is a conversation about death, creativity, faith without absolutes, and why your life should be a gift. Hosted on Acast. See acast.com/privacy for more information.
In this December Classic episode of Research Insights, host Dale Hall revisits a timely and impactful conversation originally released on July 23, 2018. The episode explores the U.S. Human Mortality Database and highlights the critical value of long-term, reliable mortality records in understanding population health. As we mark Universal Health Coverage Day this December, this episode serves as a compelling reminder that strong health systems depend on strong data. From identifying mortality patterns to analyzing longevity trends, this discussion offers insights that are essential for designing equitable and sustainable health coverage for all. Listeners will hear how mortality data shapes policy and actuarial practice—and why it matters now more than ever.
It's a holly jolly solstice at the home of Winter's Bite as Orillo, Shriek, and Tessel realize that ginger bark may have some bite.Come join us on Discord:https://discord.gg/ntaEjvcConsider supporting us on Patreon!https://www.patreon.com/IndoorAdventuresMerch: indooradventure.redbubble.com
This is a fan fav episode. You are living through exciting and strange times. There are so many technological advances with AI, space travel, NFTs, and a rapidly changing culture with social media, it's near impossible to just turn ‘off'. Let's admit it, FOMO is real and it keeps a lot of people connected when they're not even sure why they're connected. When was the last time you unplugged and took on a challenge you weren't sure you'd complete? How long has it been since you've sat with yourself in total silence or allowed yourself to just be bored out of your mind? Author and journalist, Michael Easter, joins me today to discuss his journey and share the lessons and insights he's gained from spending a month in the Arctic surviving. Hunting his own food, carrying heavy loads, and sitting with absolute boredom are just part of his story. As you listen to his story, it is my hope you will consider ways you step out of your comfort zone. There is something very freeing about being able to shake things up and break your routines and habits to improve the quality of your life in unconventional ways. This episode is about facing discomfort and finding new ways to challenge yourself for the better. Order Michael Easter's new book, The Comfort Crisis - https://amzn.to/3ihebjB Original air date: 8-5-2021 SHOW NOTES: 0:00 | Introduction to Michael Easter 1:05 | The Comfort Crisis Explained 3:02 | Journey to the Arctic 5:03 | Recovering from Alcohol 7:40 | Outside the Comfort Zone 8:55 | Helicopter Parenting Losing Challenges 12:16 | Touching Controversial Topics 14:53 | Challenges Surviving the Arctic 20:11 | Problem Creep 28:05 | Need for Rite of Passage 35:12 | Metaphorical Lions for Passage 41:19 | Comfort Creep & Habits 44:22 | Breaking Routine to be Present 47:45 | Discomfort and Boredom 50:00 | Benefits of Boredom 57:12 | Daily Routine 1:02:11 | Rucking & Human Design 1:14:05 | Killing His 1st Caribou 1:17:16 | Life Cycle & Mortality 1:27:16 | “This Too Shall Pass” 1:30:31 | Want to Live Forever? 1:39:12 | Assigning Meaning to Life 1:42:20 | Rites of Passage Transformation 1:46:12 | Problem Creep Comparison 1:50:34 | Finding Gratitude Learn more about your ad choices. Visit megaphone.fm/adchoices
This week on the Working Ranch Radio Show, we kick off a two-part countdown of the Top Shows of 2025, highlighting some of the most meaningful conversations from the past year. In Part 1, we revisit shows ranked number eight through number five — discussions that challenged how we think about grazing management, calving-season decisions, long-term commitment in the cattle business, and what it takes to keep ranching viable amid labor, time, and generational pressures. Links to Shows: #8: Ep 216: Tips for Successful Su Shows mmer Grazing w/ Dr. Allen Williams #7: Ep 230: Rethinking Your Calving Window #6: Ep 231: Markets, Mandates, and Mortality w/ Dr. Nevil Speer #5: Ep 228: Doing More with Less: Precision Ranching with Chip Kemp #workingranchmagazine #ranchlife #ranching #dayweather #weather #agweather #beef #cows #livestock #cattle #Allflex #Neogen #IngentyBeef #NewGeneration #TankToad #WorkingRanchRadio #BeefCattle #CowCalf #CattleManagement #Cattlemen #BeefProduction #RanchProfitability #RanchEconomics #CattleHealth #Ranchers #AgPodcast #RuralAmerica #GrazingManagement #CalvingSeason #ForageManagement #RanchManagement #SuccessionPlanning #DoingMoreWithLess #AgTechnology #PrecisionAg #RanchTech
In this episode of Acta Non Verba, host Marcus Aurelius Anderson sits down with Rod Yancy — entrepreneur, writer, attorney, and founder of Oath and Bootleg. Rod shares how he’s found success across multiple industries, from law and financial planning to software and now music. The conversation explores what it means to build companies that serve people, live with intention, and innovate within the modern music industry. Rod offers timeless lessons on creativity, courage, and taking action to turn vision into reality. Episode Highlights: 5:04 - The Power of Mortality in EntrepreneurshipRod discusses how contemplating mortality (memento mori) shaped his philosophy and inspired the founding of Oath, emphasizing the importance of living intentionally and making meaningful decisions. 9:39 - Overcoming the Success TrapRod and Marcus explore the “success trap” many entrepreneurs fall into—chasing money or status at the expense of fulfillment, health, and relationships, and how true success requires self-awareness and balance. 40:07 - Delegation and Leadership Lessons from Richard BransonRod shares advice from Richard Branson about the importance of delegation, empowering others, and stepping back as a leader to allow the team to thrive, even if it means feeling less “needed.” 56:00 - Empowering Artists with New Revenue StreamsRod introduces his new venture, Bootleg, which helps artists monetize live concert recordings, providing fans with unique experiences and artists with ongoing revenue, illustrating innovation and creative entrepreneurship. Rod Yancy is a serial entrepreneur, attorney, and founder of Oath, a company dedicated to helping people live intentionally by contemplating their mortality and planning their legacy. With a background in philosophy and law, Rod has built and scaled multiple businesses, including Oath Planning and Bootleg, a platform empowering artists to monetize live performances. Known for his creative approach, resilience, and commitment to meaningful work, Rod draws inspiration from both ancient philosophy and modern mentors like Richard Branson. He is passionate about fostering innovation, supporting artists, and helping others find purpose beyond financial success. Learn more about the gift of Adversity and my mission to help my fellow humans create a better world by heading to www.marcusaureliusanderson.com. There you can take action by joining my ANV inner circle to get exclusive content and information.See omnystudio.com/listener for privacy information.
Interview with Anupam B. Jena, MD, PhD, and Vishal R. Patel, MD, MPH, authors of Mortality Among Surgeons in the United States. Hosted by Jamie Coleman, MD. Related Content: Mortality Among Surgeons in the United States
Chegou o episódio escolhido por vocês! Marcela Belleza e Joanne Alves convidam Carol Millon para conversar sobe 6 clinicagens de inibidores de SGLT2, as gliflozinas:Indicações além do DMRisco de CAD euglicêmicaQuando não usar?Cuidados com doença aguda (sick day) e hipovolemiaCuidados pré-operatórioRisco de fratura e amputaçãoReferências:1. Bailey CJ, et al. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013;11:43. Published 2013 Feb 20. doi:10.1186/1741-7015-11-432. Bersoff-Matcha SJ, et al. Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. Ann Intern Med. 2019;170(11):764-769. doi:10.7326/M19-00853. Chang HY, et al. Association Between Sodium-Glucose Cotransporter 2 Inhibitors and Lower Extremity Amputation Among Patients With Type 2 Diabetes. JAMA Intern Med. 2018;178(9):1190-1198. doi:10.1001/jamainternmed.2018.3034 4. Clar C, et al. Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. BMJ Open. 2012 Oct 18;2(5):e001007. doi: 10.1136/bmjopen-2012-001007. PMID: 23087012; PMCID: PMC3488745.5. Das SR, et al. 2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2020 Sep 1;76(9):1117-1145. doi: 10.1016/j.jacc.2020.05.037. Epub 2020 Aug 5. PMID: 32771263; PMCID: PMC7545583. 6. Fralick M, et al. Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study. BMJ. 2020;370:m2812. Published 2020 Aug 25. doi:10.1136/bmj.m28127. Li D, et al. Urinary tract and genital infections in patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors: A meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2017;19(3):348-355. doi:10.1111/dom.128258. Neal B, et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)--a randomized placebo-controlled trial. Am Heart J. 2013;166(2):217-223.e11. doi:10.1016/j.ahj.2013.05.0079. Nyirjesy P, et al. Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin. 2012;28(7):1173-1178. doi:10.1185/03007995.2012.69705310. Perkovic V, et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med. 2019;380(24):2295-2306. doi:10.1056/NEJMoa181174411. Rosenwasser RF, et al. SGLT-2 inhibitors and their potential in the treatment of diabetes. Diabetes Metab Syndr Obes. 2013 Nov 27;6:453-67. doi: 10.2147/DMSO.S34416. PMID: 24348059; PMCID: PMC3848644.12. Sridharan K, Sivaramakrishnan G. Risk of limb amputation and bone fractures with sodium glucose cotransporter-2 inhibitors: a network meta-analysis and meta-regression. Expert Opin Drug Saf. 2025;24(7):797-804. doi:10.1080/14740338.2024.237775513. Ueda P, et al. Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study. BMJ. 2018;363:k4365. Published 2018 Nov 14. doi:10.1136/bmj.k436514. Watts NB, et al. Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 Jan;101(1):157-66. doi: 10.1210/jc.2015-3167. Epub 2015 Nov 18. PMID: 26580237; PMCID: PMC4701850.15. Zhuo M, et al. Association of Sodium-Glucose Cotransporter-2 Inhibitors With Fracture Risk in Older Adults With Type 2 Diabetes. JAMA Netw Open. 2021;4(10):e2130762. Published 2021 Oct 1. doi:10.1001/jamanetworkopen.2021.3076216. Emerson Cestari Marino, Leandra Anália Freitas Negretto, Rogério Silicani Ribeiro, Denise Momesso, Alina Coutinho Rodrigues Feitosa, Marcos Tadashi Kakitani Toyoshima, Joaquim Custódio da Silva Junior, Sérgio Vencio, Marcio Weissheimer Lauria, João Roberto de Sá, Domingos A. Malerbi, Fernando Valente, Silmara A. O. Leite, Danillo Ewerton Oliveira Amaral, Gabriel Magalhães Nunes Guimarães, Plínio da Cunha Leal, Maristela Bueno Lopes, Luiz Carlos Bastos Salles, Liana Maria Torres de Araújo Azi, Amanda Gomes Fonseca, Lorena Ibiapina M. Carvalho, Francília Faloni Coelho, Bruno Halpern, Cynthia M. Valerio, Fabio R. Trujilho, Antonio Carlos Aguiar Brandão, Ruy Lyra e Marcello Bertoluci. Rastreamento e Controle da Hiperglicemia no Perioperatório – Posicionamento Conjunto da Sociedade Brasileira de Diabetes (SBD), Sociedade Brasileira de Anestesiologia (SBA) e Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica (ABESO). Diretriz Oficial da Sociedade Brasileira de Diabetes (2025). DOI: 10.29327/5660187.2025-10 , ISBN: 978-65-5941-367-6.17. Singh LG, Ntelis S, Siddiqui T, Seliger SL, Sorkin JD, Spanakis EK. Association of Continued Use of SGLT2 Inhibitors From the Ambulatory to Inpatient Setting With Hospital Outcomes in Patients With Diabetes: A Nationwide Cohort Study. Diabetes Care. 2024;47(6):933-940. doi:10.2337/dc23-112918. Mehta PB, Robinson A, Burkhardt D, Rushakoff RJ. Inpatient Perioperative Euglycemic Diabetic Ketoacidosis Due to Sodium-Glucose Cotransporter-2 Inhibitors - Lessons From a Case Series and Strategies to Decrease Incidence. Endocr Pract. 2022;28(9):884-888. doi:10.1016/j.eprac.2022.06.00619. Umapathysivam MM, Morgan B, Inglis JM, et al. SGLT2 Inhibitor-Associated Ketoacidosis vs Type 1 Diabetes-Associated Ketoacidosis. JAMA Netw Open. 2024;7(3):e242744. Published 2024 Mar 4. doi:10.1001/jamanetworkopen.2024.274420. Fleming N, Hamblin PS, Story D, Ekinci EI. Evolving Evidence of Diabetic Ketoacidosis in Patients Taking Sodium-Glucose Cotransporter 2 Inhibitors. J Clin Endocrinol Metab. 2020;105(8):dgaa200. doi:10.1210/clinem/dgaa20021. Neuen BL, Young T, Heerspink HJL, et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2019;7(11):845-854. doi:10.1016/S2213-8587(19)30256-622. Braunwald E. Gliflozins in the Management of Cardiovascular Disease. N Engl J Med. 2022;386(21):2024-2034. doi:10.1056/NEJMra211501123. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2015;373(22):2117-2128. doi:10.1056/NEJMoa150472024. Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med. 2017;377(7):644-657. doi:10.1056/NEJMoa161192525. Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019;380(4):347-357. doi:10.1056/NEJMoa181238926. McMurray JJV, Solomon SD, Inzucchi SE, et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2019;381(21):1995-2008. doi:10.1056/NEJMoa191130327. Packer M, Anker SD, Butler J, et al. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383(15):1413-1424. doi:10.1056/NEJMoa202219028. Anker SD, Butler J, Filippatos G, et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451-1461. doi:10.1056/NEJMoa210703829. Heerspink HJL, Stefánsson BV, Correa-Rotter R, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446. doi:10.1056/NEJMoa202481630. The EMPA-KIDNEY Collaborative Group, Herrington WG, Staplin N, et al. Empagliflozin in...
Interview with Anupam B. Jena, MD, PhD, and Vishal R. Patel, MD, MPH, authors of Mortality Among Surgeons in the United States. Hosted by Jamie Coleman, MD. Related Content: Mortality Among Surgeons in the United States
An interview with Dr. Jason Karp, Founder & CEO, Coach, Exercise Scientist and Author.For many years, I've been hearing people in the fitness industry talk about how your fitness and your physique is 80% nutrition and 20% exercise. And all you have to do is take one exercise science class, and you know that that's incorrect. And how can your nutrition be four times more important than exercise?Dr. Jason KarpInspiration for writing Can You Outrun a Donut?Five components of physical fitnessImportance of nutrition versus exerciseTwin studies on genetic determinants of body mass index Benefits of runningRunning and the human experiencePushing your body to the limitCoaching philosophyAccessibility of runningOutrunning donuts as we ageTips for fitness professionalshttps://www.movetolivemore.com/https://www.movetolivemore.com/bookhttps://www.linkedin.com/company/move-to-live-more@MovetoLiveMore
Commentary by Dr. Jian'an Wang.
The pros and cons of natural vs synthetic vitamins; Telehealth site for ADD meds lands founder in prison; Why eradicating H. pylori may set the stage for Alzheimer's; Why integrative physicians often don't accept insurance; Far-infrared phototherapy may offer “electroceutical” treatment for dementia; Hobbies may forestall all-cause mortality—by 29%!
#ThisMorning | Reducing the #Mortality #Risk of #Breast #Cancer | Steven Narod, MD, FRCPC, FRSC, Tier I Canada Research Chair in Breast Cancer, University of Toronto | #Tunein: broadcastretirementnetwork.com #Aging, #Finance, #Lifestyle, #Privacy, #Retirement, #Wellness
Are you good at your job but secretly burned out? In this episode, Nurse Practitioner turned Marketing Expert Lauren Leigh reveals why so many healthcare professionals get trapped in the "Zone of Excellence"—where competence and a steady paycheck keep you from finding your true purpose.Lauren shares her 15-year journey from the ER to the streets of Detroit doing harm reduction, and finally to launching her own agency, Transformative Ads. We discuss the reality of "doing more with less" in healthcare, how to identify your "Zone of Genius," and the specific marketing strategies clinicians need to build a profitable business.In this episode, we cover: Intro: Meet Lauren Leigh The reality of ER burnout: "Do more with less" The defining moment: Mortality and making the leap Advice for the stuck nurse: Self-care before the pivot The "Zone of Excellence" Trap vs. The "Zone of Genius" From bedside to business: Discovering Facebook Ads The Social Strategy RX: The S3 System for content Lauren's 3 Wisdom Gems for new entrepreneursAbout the Guest: Lauren Leigh is a Nurse Practitioner and the founder of Transformative Ads. She helps clinician entrepreneurs build profitable, purpose-driven businesses through high-level social media strategy and advertising. Website: www.transformativeads.com LinkedIn: www.linkedin.com/in/lauren-leigh-dnp
Reid is on vacation and has so much content to discuss. Jay Kelly, The Testament of Ann Lee, and the Gwyneth Paltrow x Jacob Elordi interview. Other topics include why Avatar still happens, Lost in Translation, and the backyard macabre of the Hudson Valley.Tere O'Connor at New York Live ArtsGwyneth Paltrow & Jacob Elordi Jonathan Bailey & David Corenswet◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠➩ WEBSITE ◦YOUTUBE ◦ INSTAGRAM ➩ SUPPORT:✨VIA VENMO!✨ or PATREON➩ REID ◦ JEREMY ◦ JACK◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠◠➩ withdanceandstuff@gmail.com
How does China's economic model work? Political economist Ben Norton explains the ideas behind Socialism with Chinese Characteristics, discussing China's socialist market economy, historical development, reform process, poverty reduction, industrial policy, and more. VIDEO with charts here: https://www.youtube.com/watch?v=6E89qUXTX-k Topics 0:00 Introduction 1:07 China has world's largest economy 3:01 China's economic development 3:54 Poverty reduction 6:56 Rising incomes 7:42 Life expectancy 8:57 Mortality rates 9:34 Reform and Opening Up 10:16 To get rich is glorious? 11:35 Deng Xiaoping's ideology 13:54 Primary stage of socialism 14:28 Chinese capitalists 15:54 Industrialization & urbanization 16:55 Birdcage economy (Chen Yun) 18:17 State ownership 19:40 State-owned enterprises (SOEs) 20:49 Grasp the large, let go of the small 22:22 Public property 23:16 SOE assets 24:14 Provincial & local governments 25:51 Golden shares in tech companies 26:54 Huawei, biggest worker-owned company 27:17 Rural cooperatives 29:09 Democracy in China? 31:40 Foreign investment in China 33:49 Global value chain 34:34 Foreign direct investment (FDI) 35:48 Industrial policy evolution 38:22 New quality productive forces 39:23 China's green energy revolution 40:24 World's manufacturing superpower 41:04 US deindustrialization & financialization 43:22 US bubble economy 44:37 China popped real estate bubble 46:50 Inequality & uneven development 48:31 Eras of the PRC 49:01 Common prosperity in New Era 49:34 Gini coefficient 50:26 Labor income vs capital income 51:48 Poverty alleviation 52:17 Wages of Chinese workers 52:44 Labor unions in China 55:19 USA funds anti-China labor groups 57:02 Marco Rubio takes over NED 57:32 Delivery workers 58:30 996 system is banned 59:23 Working hours in China 1:00:25 Imperialism & division of labor 1:03:51 AI & new cold war 1:04:45 Silicon Valley model: monopoly 1:05:43 Market competition in China 1:07:44 China opposes private monopolies 1:08:10 State planning 1:09:05 Cold War Two
Ed Fowler's 40-year career in fire and EMS culminates in a transformative chapter as he helps El Reno, Oklahoma, transition its EMS from private to an in-house, city-managed service—an innovative model focusing on sustainability, independence, and community trust. Ed shares his leadership philosophy grounded in accountability, clear communication, and mentoring future leaders. Amid this professional milestone, Ed confronts a life-threatening liver condition, navigating the transplant process while ensuring the EMS startup stays on course. His story offers rare insight into the human side of emergency services, touching on resilience, collaboration, and purpose when facing the edge of life itself. Beyond operational challenges, Ed's vulnerability inspires those struggling with adversity to find reasons to keep moving forward.
Drs. Jack Cush and Artie Kavanaugh preview the upcoming RNL 2026 meeting in Dallas, TX on February 7 & 8, 2026. Register at RheumNow.Live Below is the program: Saturday, February 7, 2026, 7:50 - 8:00 am Welcome & Introductions Drs. Cush and Kavanaugh 8:00 - 10:00 am POD I - Rheumatoid Arthritis: Achieving Better Outcomes 8:00 – 8:30 am Mortality in RA: A Story of Decline, Delay, or Plateau? Elena Myasoedova, MD 8:30 – 9:00 am The Mucosal Hypothesis of Rheumatoid Arthritis Kristen Demoruelle, MD 9:00 – 9:30 am ILD in RA – Recent Advances Jeffrey Sparks, MD 9:30 – 10:00 am Rheumatoid arthritis Faculty Q&A 10:00 - 10:15 am STEP 1: Placebos in Rheumatology Andreas Kerschbaumer, MD 10:15 -10:30 am STEP 2: Disease Modification in Osteoarthritis Tuhina Neogi, MD PhD 10:30 – 11:05 Break 11:05 - 12:10 pm POD II – Advancing Practice 11:05 – 11:30 am Obesity & Inflammation: Weight Management in Rheumatology Uzma Haque, MD 11:30 - 11:55 am Mitigating risk in Rheum Pts undergoing surgery Susan Goodman, MD 11:55 -12:10 pm Practice Panel Faculty Q&A 12:10 – 1:00pm Lunch 1:00 – 3:00 pm POD III – Decisions in Psoriatic Arthritis 1:00 - 1:30 pm Paradoxical Psoriasis and Strange Reactions Joseph Merola, MD 1:30 - 2:00 pm Why Do Plain X rays in Psoriatic Arthritis Arthur Kavanaugh, MD 2:00 - 2:30 pm IL-23 vs IL-17 inhibitors in PsA Andre Ribero, MD 2:30 - 3:00 pm Past, Present & Future of Gout Robert Terkeltaub, MD 3:00 - 3:30 pm Psoriatic Faculty Q&A 3:30 - 4:05 pm Break 4:05 - 4:20 pm STEP 3: Helicobacter Pylori update Byron Cryer, MD 4:20 - 4:35 pm STEP 4: History of Gout Robert Terkeltaub, MD 4:35 – 5:15 pm Keynote Address: 50 Years of Osteoporosis Michael McClung, MD 5:30 – 7:00 pm Reception Sunday, February 8, 2026 Day TOPIC Speaker 7:50-8:00 am Welcome & Introductions Drs. Cush and Kavanaugh 8:00 - 10:00 am POD IV – Staying Ahead of Spondyloarthritis 8:00 – 8:30 am Diagnosing Axial Spondyloarthritis in 2026 Denis Poddubnyy, MD 8:30 – 9:00 am Spondyloarthritis Complications Jessica Walsh, MD 9:00 – 9:30 am 2026 Advances in Spondyloarthritis Catherine Bakewell, MD 9:30 – 10:00 am Spondyloarthritis Faculty Q&A 10:00 – 10:15 am STEP 5: Asymptomatic Elevation of CK Rojit Agarwal, MD MS 10:15 – 10:30 am STEP 6: Update on Myositis Antibodies Rojit Agarwal, MD MS 10:30 – 11:05 am Break 11:05 – 12:10 am POD V – Highlights in Autoimmune Disease 11:05 - 11:35 am SMILE Study – Hydroxychloroquine in ANA+ Arthralgia Nancy Olsen, MD 11:35 – 12:05 am Sjogren's Treatment Landscape in 2026 Matthew Baker, MD 12:05 - 12:20 pm Autoimmune Faculty Q&A 12:20 – 1:25 pm POD VI - Large & Small Vessel Vasculitis 12:20 – 12:45 pm Embracing Relapses in PMR and GCA Michael Putman, MD 12:45 - 1:10 pm Small vessel vasculitis Clay Cockerell, MD 1:10 - 1:25 pm Vasculitis Faculty Q&A 1:30 pm Adjourn
Today, I'm joined once again by the incredible Dr. Bill Lawrence, a true pioneer in the field of longevity research and one of the most requested guests on this podcast. Dr. Lawrence trained directly with Professor Vladimir Khavinson—the scientist who discovered and developed bioregulator peptides—and has spent the last eight years leading some of the most exciting field research in this space. Episode Timestamps: Welcome and introduction to Longevity Podcast ... 00:00:00 Origins and early use of bioregulator peptides in Soviet research ... 00:05:39 Organ-specific peptide mechanisms and targeting ... 00:08:28 Dr. Lawrence's collaboration with Professor Cavinson ... 00:12:17 Overview of American clinical studies and study protocols ... 00:14:13 Measuring biological age: telomeres and epigenetic markers ... 00:15:06 Key Russian studies and impact of peptides on mortality ... 00:17:00 Peptides as ultimate epigenetic switches and DNA repair ... 00:20:00 Importance of pineal and thymus peptides in protocols ... 00:22:28 Advances in peptide testing and lab beta-testing ... 00:28:05 Clinical outcomes: organ regeneration and normalized function ...00:35:54 Bioregulator peptides vs. synthetics: modulation vs. boosting ... 00:39:28 Dr. Lawrence's personal telomere and epigenetic age results ... 01:07:56 Impact of stress and meditation on telomere length ... 01:10:37 Group results: significant telomere and epigenetic age reversal ... 01:13:03 System-level organ age tracking and protocol targeting ... 01:27:14 International expansion and next steps in peptide research ... 01:37:03 Our Amazing Sponsors: Kineon - near-infrared light helps improve circulation, oxygen delivery, and mitochondrial function, which can support focus, recovery, and even overall brain health. Visit kineon.io/NATNIDDAM and get 10% off! BEAM Minerals - Mineral deficiency support. One shot in the morning, tastes like water, and you've just restored every essential mineral your cells are craving. Go to beamminerals.com, use code NAT20, and get 20% off your first order. Nootropept by LVLUP - an advanced cognitive enhancement formula that combines fast-acting neuropeptides, cholinergic support, and mitochondrial-boosting compounds to sharpen mental clarity, memory, and long-term brain performance. Visit https://lvluphealth.com/ and use code NAT at checkout for 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
Send us a textDr. Matthew Laughon, Professor at University of North Carolina and NICHD Neonatal Research Network investigator, presents the landmark PDA Management Trial comparing expectant management versus active medical treatment (indomethacin, ibuprofen, or acetaminophen). The trial stopped early due to futility and safety concerns—mortality exceeded 10% in the treatment group versus 4% with expectant management, with more infection-related deaths among treated infants. Secondary outcomes (BPD, NEC, ROP) showed no differences. The study included infants with symptomatic PDAs but excluded those with severe cardiopulmonary compromise. Findings support expectant management for symptomatic PDAs through 21 days of life, aligning with recent guidelines recommending no routine treatment in the first two weeks. Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
The lung Composite Allocation Score (CAS) was implemented in 2023, and has shown to increase lung transplant rates and lower waitlist mortality. Host Alice Gallo de Moraes, MD, of the Mayo Clinic, interviews experts Mary Raddawi, MD, of Columbia University Irving Medical Center, and Amy Skiba, of the Lung Transplant Foundation, on the importance of CAS and how it has changed outcomes for lung transplant patients.
In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page. Through Dec. 6th, 50% off a Reverse Dieting Strategy call with a Mind Pump coach. Visit: http://www.reversedietcall.com/ ** Code DECEMBER50 at checkout ** Mind Pump Fit Tip: How to use carbs for the gains! (2:24) The importance of being aware of how much protein you can handle at one sitting. (21:46) The mortality of pro bodybuilders. (29:50) The red-light "pump." (37:22) Cats vs Dogs. (41:40) Odds of success going into a rehab facility vs. doing it on your own. (45:59) Human safaris. (48:06) The plugged vs. the unplugged. (50:45) #Quah question #1 – How to scale back on cardio when you've done intense endurance for 15 years? (1:05:59) #Quah question #2 – How can we train our Central Nervous System to keep up a little better? Is there anything that can be done immediately after realizing we went a little too hard? (1:09:48) #Quah question #3 – How do I know if I'm getting stronger or if it's just my central nervous system adapting? Especially if I've been training for 10+ years? (1:11:44) #Quah question #4 – How do you feel about posture correctors? My son has bad forward shoulders, and he's been doing some exercises to correct them. He brought up this posture corrector, and I'm curious about your guys' thoughts. (1:13:30) Related Links/Products Mentioned Visit Joovv for an exclusive offer for Mind Pump listeners! ** Code MINDPUMP to get $50 off your first purchase. 0% financing available! ** Visit Rock Recovery Center for the exclusive offer for Mind Pump listeners! ** By filling out the form and scheduling your call, you'll also be entered for a chance to win a free 60-day scholarship at Rock Recovery Center, their premier treatment center in West Palm Beach, Florida. Don't wait—take the first step today. ** Through Dec. 6th, 50% off a Reverse Dieting Strategy call with a Mind Pump coach. Visit: http://www.reversedietcall.com/ ** Code DECEMBER50 at checkout ** Mind Pump Store Mind Pump #2644: Eight Best Carbs for Bodybuilding & More (Listener Live Coaching) Carb Cycling: A Good Way To Lose Fat? – Mind Pump Blog The Benefits Of Carb Cycling – Mind Pump Show Peter Attia IG clip Mortality in male bodybuilding athletes - Oxford Academic Dog Ownership Linked to 40% Reduced Risk of Dementia The truth behind sick 'human safari' killings Get a free Sample Pack of LMNT's most popular drink mix flavors with any purchase! As always, LMNT offers no-questions-asked refunds on all orders. The 8-count LMNT Sample Pack doubles down on our most popular flavors: Citrus Salt, Raspberry Salt, Watermelon Salt, and Orange Salt (2 stick packs of each flavor): Visit DrinkLMNT.com/MindPump Mind Pump #2312: Five Steps to Bounce Back From Overtraining 7-Day Overtraining Rescue Guide | Free by Mind Pump Media Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Zach Bitter (@zachbitter) Instagram Paul Saladino, MD (@paulsaladinomd) Instagram Peter Attia, M.D. (@peterattiamd) Instagram Tom Bilyeu (@tombilyeu) Instagram Dave Asprey (@dave.asprey) Instagram Thomas Conrad (@realrecoverytalktom) Instagram Ben Bueno (@realrecoverytalkben) Instagram
In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Vlad Vukicevic , CEO and founder of the Better & Better, who shares his remarkable journey from childhood cancer survivor to entrepreneur in the health and wellness space. The conversation explores themes of longevity, health challenges, mental health, and innovative health products, emphasizing the importance of preventive care and personal growth. For Audience · Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ ! Takeaways · Vlad's journey began with a cancer diagnosis at age five. · He underwent extensive treatment, including chemotherapy and a bone marrow transplant. · The experience shaped his understanding of mortality and health. · Vlad's family provided crucial support during his health challenges. · He developed a hypochondriac tendency due to his past health issues. · Vlad emphasizes the importance of ongoing health monitoring. · He founded Better and Better to innovate in health products. · The company focuses on integrating health benefits into everyday routines. · Vlad believes in continuous improvement in health and wellness. · He aims to make health management easier for everyone. Chapters 00:00 Introduction to Longevity and Health 01:34 Vladimir's Early Health Challenges 04:43 The Impact of Childhood Cancer 09:06 Coping with Mortality and Mental Health 13:42 Navigating Teenage Years Post-Cancer 17:16 Ongoing Health Monitoring and Preventive Care 19:59 The Evolution of Health Awareness 22:46 Entrepreneurial Journey and Health Innovations 27:24 The Future of Health Products 32:00 Conclusion and Personal Growth To learn more about Vlad: Website: https://www.betterandbetter.com/ Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.
The Guys Like Us is joined with Joshua Porter who is an author and pastor. In this episode we talk about the importance of dying to self as a Christian disciple. The path is not a climb of ascent through might and willpower. But rather, laying down performance and self-help for a deep reliance and trust in the good news of Jesus. Josh's book How to Die: Chaos, Mortality, and the Scandal of Christian Discipleship can be found where books are sold.
In this podcast, Regan Archibald dives into the three organ systems most crucial for longevity—the brain, heart, and muscles—focusing especially on how VO₂ max and grip strength predict long-term health and mortality risk. He shares personal fitness experiences, including using VO₂ max testing, dead hangs, and the Norwegian 4x4 interval protocol to improve cardiovascular performance and reverse age-related heart changes. Regan emphasizes practical strategies such as Zone 2 training, peptides for mitochondrial support, diagnostic testing, and building habits that protect metabolic and cardiovascular health. Through stories about his own training, his children's fitness challenges, and the Ageless Future roadmap, he encourages listeners to set ambitious 90-day health goals, improve daily exercise routines, and commit to becoming the fittest version of themselves.LIKE/FOLLOW/SUBSCRIBE AGELESS FUTURE:YouTube -https://www.youtube.com/@ReganArchibald / https://www.youtube.com/@Ageless.FutureLinkedIn: https://www.linkedin.com/in/regan-archibald-ab70b813Instagram: https://www.instagram.com/ageless.future/Facebook: https://www.facebook.com/AgelessFutureHealth/
One on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meetingSupport the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USThe Lila Code: https://orcid.org/0009-0008-4612-3942
The Father Hoods spin it back with another #throwback gem, revisiting a moment where the DJ EFN, Manny Digital, and KGB got deep about the parts of parenting most people keep quiet. Manny opens the convo with a real heart piece — the power of showing love to your kids, especially our sons, and why affection matters more than we admit. The Dads break down their own styles and how they stay intentional with them. DJ EFN jumps in with a flashback update from the time his partner was pregnant with their second child. He shared how he's wanted another daughter, handling that second-time-around calm, and the difference between first-kid chaos and seasoned parenting confidence. Then the table turns to a universal parent truth: the thoughts that keep you up at night. The future of our kids. Mortality. That heavy paternal anxiety every dad wrestles with sooner or later. Before the throwback wraps, Manny steps in with a quick flex. The Father Hoods website is officially up, locked in as the hub for all the episodes and other Father Hoods content. What You'll Hear in This Episode: [00:01:09] Real Dads Show Love Loud [00:10:14] Girl Dad x Boy Dad [00:18:00] The Fears You Don't Say Out Loud [00:25:38] The Father Hoods HQ Launch Why Hit Play: DJ EFN, Manny Digital & KGB take fatherhood realness and turn it into a verse that sticks! Learn more about your ad choices. Visit megaphone.fm/adchoices
We review BRUEs (Brief Resolved Unexplained Events). Hosts: Ellen Duncan, MD, PhD Noumi Chowdhury, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/BRUE.mp3 Download Leave a Comment Tags: Pediatrics Show Notes What is a BRUE? BRUE stands for Brief Resolved Unexplained Event. It typically affects infants 60 days old Gestational Age: GA > 32 weeks (and Post-Conceptional Age > 45 weeks) Frequency: This is the first episode Duration: Lasted < 1 minute Intervention: No CPR performed by a trained professional Clinical Picture: Reassuring history and physical exam Management for Low Risk: Generally do not require extensive testing or admission. Prioritize safety education/anticipatory guidance. Ensure strict return precautions and close outpatient follow-up (within 24 hours). High Risk Criteria Any infant not meeting the low-risk criteria is automatically High Risk. Additional red flags include: Suspicion of child abuse History of toxin exposure Family history of sudden cardiac death Abnormal physical exam findings (trauma, neuro deficits) Management for High Risk: Requires a more thorough evaluation. Often requires hospital admission. Note: Serious underlying conditions are identified in approx. 4% of high-risk infants. Differential Diagnosis: “THE MISFITS” Mnemonic T – Trauma (Accidental or Non-accidental/Abuse) H – Heart (Congenital heart disease, dysrhythmias) E – Endocrine M – Metabolic (Inborn errors of metabolism) I – Infection (Sepsis, meningitis, pertussis, RSV) S – Seizures F – Formula (Reflux, allergy, aspiration) I – Intestinal Catastrophes (Volvulus, intussusception) T – Toxins (Medications, home exposures) S – Sepsis (Systemic infection) Workup & Diagnostics Step 1: Stabilization ABCs (Airway, Breathing, Circulation) Point-of-care Glucose Cardiorespiratory monitoring Step 2: Diagnostic Testing (For High Risk/Symptomatic Patients) Labs: VBG, CBC, Electrolytes. Imaging: CXR: Evaluate for infection and cardiothymic silhouette. EKG: Evaluate for QT prolongation or dysrhythmias. Neuro: Consider Head CT/MRI and EEG if there are concerns for trauma or seizures. Clinical Pearl: Only ~6% of diagnostic tests contribute meaningfully to the diagnosis. Be judicious—avoid “shotgunning” tests in low-risk patients. Prognosis & Outcomes Recurrence: Approximately 10% (lower than historical ALTE rates of 10-25%). Mortality: < 1%. Nearly always linked to an identifiable cause (abuse, metabolic disorder, severe infection). BRUE vs. SIDS: These are not the same. BRUE: Peaks < 2 months; occurs mostly during the day. SIDS: Peaks 2–4 months; occurs mostly midnight to 6:00 AM. Take-Home Points Diagnosis of Exclusion: You cannot call it a BRUE until you have ruled out obvious causes via history and physical. Strict Criteria: Stick strictly to the Low Risk criteria guidelines. If they miss even one (e.g., age < 60 days), they are High Risk. Education: For low-risk families, the most valuable intervention is reassurance, education, and arranging close follow-up. Systematic Approach: For high-risk infants, use a structured approach (like THE MISFITS) to ensure you don’t miss rare but reversible causes. Read More
Psychologist and writer Tony Bates and his old pal Denis Cagney join Brendan to talk about reconnecting more than 50 years after first striking up a conversation at school. Denis and Tony share the wisdom that comes with age and their life experience. They talk about what their friendship means now, and Denis shares the reality of living with MND.
In this conversation with entrepreneur and outsourcing leader Carmen Williams, we unpack the moment she walked into work, felt a physical “no” in her stomach, and quit her job that same day. No plan, no runway, no strategy deck—just bravery born from clarity.This episode isn't about hustle culture. It's about permission—to pivot, to shrink your life, to rebuild your identity, and to stop performing your way into burnout.We explore why corporate stability is an illusion, why minimalism creates freedom, how virtual teams scale your capacity, and why the “first hire fantasy” founders chase is usually wrong.We also talk about life after collapse—the rebirth that happens when you stop clinging to the version of yourself that was built to survive, not thrive.No hype. Just the quiet courage of starting over.TL;DR* The brave pivot: Carmen quit her job in one day after realizing life is short and fear is expensive.* Job security is riskier than entrepreneurship: One employer = one point of failure.* Minimalism is leverage: Less stuff, lower burn rate, fewer emergencies.* Founders hire the wrong “clone”: You don't need another visionary—you need a steady executor.* AI + VAs is the winning combo: AI increases the demand for great operators; it doesn't replace them (yet).* Saying “no” builds more trust than yes: Filtering clients improves ROI and reputation.What we unpack1. The moment you stop pretending you have timeCarmen's turning point came when her mother was diagnosed with a terminal illness—20 years older than her. Mortality compresses priorities.She realized: “If I knew I had 20 years left, would I stay here?”Her answer was a clean no.2. The illusion of corporate safetyDoug reflects on climbing into bigger houses and bigger bills—only to realize everything you own also owns a piece of you.Entrepreneurs face volatility monthly.Employees face catastrophe suddenly.Pick your pain.3. Minimalism as a business strategyDoug downsized from 3,800 sq ft → 560 sq ft.Less space. Fewer things. More intention.The easy life is the one with fewer dependencies.4. Why founders hire the wrong personalityEntrepreneurs imagine a “mini-me” assistant—someone spontaneous, creative, high-initiative.What they need is the opposite:A detail-driven operator who finishes what the founder starts.5. How Carmen accidentally built a 100-person outsourcing companyShe hired VAs for her own consulting practice.People kept asking for help.She kept saying no—until the market refused to let her.No website. No pitch deck. Twenty VAs anyway.6. Why AI doesn't replace VAs—it amplifies themHer teams use AI as a force multiplier, not a threat.Training loops, outside experts, and self-directed learning have made her VAs more valuable—not redundant.Memorable lines* “If you only have one income stream, you don't have stability—you have a trap.”* “Minimalism isn't aesthetic. It's leverage.”* “Your first hire shouldn't be you—it should be your opposite.”* “The day you stop pretending you have time is the day you become brave.”* “AI doesn't replace people. It replaces excuses.”GuestCarmen Williams — Founder & CEO of a global outsourcing agency supporting 100+ virtual assistants across multiple industries. Known for helping entrepreneurs scale through operational discipline, delegation frameworks, and mindset shifts around capacity and courage.LinkedIn: https://www.linkedin.com/in/carmenwilliamsau/Website: https://globalteams.com.au/Why this mattersIf you want your second life to work, you can't drag your first-life habits with you.That means:* lower burn rate* fewer possessions* more clarity* better support* braver decisions* honest self-assessmentYou can't rebuild while holding onto the version of yourself that burned out.Call to ActionIf this conversation lit something up for you, don't just let it fade. Come join me inside the Second Life Leader community on Skool. That's where I share the frameworks, field reports, and real stories of reinvention that don't make it into the podcast. You'll connect with other professionals who are actively rebuilding and leading with clarity. The link is in the show notes—step inside and start building your Second Life today.https://secondlifeleader.com This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.dougutberg.com
Send us a textTRIGGER WARNING: Necrophilia and other sexual practices. In this episode, we study serial killer and necrophile David Fuller of Kent, England, as well as the psychology of necrophilia.E-mail me at Pugmomof1@gmail.com; visit me on Instagram as True Crime University_ or join our Facebook group, True Crime University Discussion GroupTrue Crime University is part of the Debauchery Media Network. Visit all our podcasts at welcometothedebauchery.comResources: Wikipedia, kentonline.co.uk, People, "Mortality" Tippet, A "Dignity in life vs dignity in death: The David Fuller inquiry and the need for proportionate justice against crimes of necrophilia in British law" (2025), bbc.com, theguardian.com, the Sun, Sky News, allthatsinteresting.com, standard.co.uk/news, K9protector.co.uk, truecrimedatabase.com, webarchive.nationalarchives.gov.uk, law.cornell.edu, psychologs.com/thepsychologybehindnecrophilia, International Journal of Engineering, Management and Humanities (2023)- Necrophilia: Loving the Dead, judiciary.uk/wp-content, sk.sagepub.com/encyJoin our Patreon for only $2 a month! Patreon.com/TrueCrimeUni... Teacher's Pet tierJoin our Patreon for only $2 a month! Patreon.com/TrueCrimeUni... Teacher's Pet tier
SPONSORS: 1) STOPBOX: Not only do you get 10% Off your entire ordernwhen you use code JULIAN at https://stopboxusa.com , but they are also giving you Buy One Get One Free for their StopBox Pro.#stopboxpod 2) EXPRESS VPN: Secure your online data TODAY by visiting http://ExpressVPN.com/JULIANDOREY PATREON: https://www.patreon.com/JulianDorey (***TIMESTAMPS in Description Below) ~ David Ferrugio is a Death Expert & YouTuber. He hosts the show, "DEAD Talks," in which he discusses grief and death with guests who have lost loved ones in a light hearted, easy to digest, and often humorous manner. DAVID's LINKS: YT: https://www.youtube.com/@deadtalkspodcast IG (PODCAST): https://www.instagram.com/deadtalkspodcast/?hl=en IG (PERSONAL): https://www.instagram.com/ferrugio/?hl=en FOLLOW JULIAN DOREY INSTAGRAM (Podcast): https://www.instagram.com/juliandoreypodcast/ INSTAGRAM (Personal): https://www.instagram.com/julianddorey/ X: https://twitter.com/julianddorey JULIAN YT CHANNELS - SUBSCRIBE to Julian Dorey Clips YT: https://www.youtube.com/@juliandoreyclips - SUBSCRIBE to Julian Dorey Daily YT: https://www.youtube.com/@JulianDoreyDaily - SUBSCRIBE to Best of JDP: https://www.youtube.com/@bestofJDP ****TIMESTAMPS**** 0:00 – Intro 1:23 – 9/11 Childhood, Losing Dad, Trauma, Dead Talks 13:44 — Child Grief, Memory Gaps, Public Attention, What to Say 23:26 — Age 12 Trauma, Last Goodbye, Gratitude Over Fear 35:06 — Fear Illusion, Cambodia Moment, Mindset, Unknown 42:15 — Mom, Anxiety Cycles, Rip Band-Aid, Living Again 52:47 — Fight-or-Flight, Bruce Lipton, Grief Recipe, Placebo 1:03:07 — 2020 Mortality, Big Questions, Info Overload, Sagan 1:14:16 — Inner Child, Insecurity, Life Lessons, Soul Contracts 1:22:28 — 3,000 Souls Joke, Reincarnation, Many Masters, Epigenetics 1:31:38 — Kendrick Lyrics, Past Life Regression, Hypnosis, Religion Mix 1:43:45 — Afterlife, Dogma, Mediumship, Scripture Interpretation 1:53:34 — Belief Defense, Groupthink, “I Don't Know,” Build Journey 2:03:10 — Grounding, Choosing Thoughts, ICU Scare, Chinese Farmer 2:14:30 — Chain Reaction, Worst → Good, NDE Home, Zero Worry 2:24:37 — NDE Peace, Nothingness, Old vs New Souls, 9/11 Sign 2:34:10 — Timing, Signs, Allowing vs Forcing, Before/After Life Split 2:43:44 — Tower 7, False Flags, Small Group Theory, Anger + Acceptance 2:52:07 — Exposure Therapy, 9/11 Footage, Unanswered Truth, Helping Others 3:01:29 — David's Work CREDITS: - Host, Editor & Producer: Julian Dorey - COO, Producer & Editor: Alessi Allaman - https://www.youtube.com/@UCyLKzv5fKxGmVQg3cMJJzyQ - In-Studio Producer: Joey Deef - https://www.instagram.com/joeydeef/ Julian Dorey Podcast Episode 359 - David Ferrugio Music by Artlist.io Learn more about your ad choices. Visit podcastchoices.com/adchoices
This issue will review: 1. Screening Natriuretic Peptide Levels Predict Heart Failure and Mortality in Individuals with Type 1 and Type 2 Diabetes without Known Heart Failure 2. The Risk of Acute Pancreatitis and Biliary Events After Initiation of Incretin-Based Medications In Patients with Type 2 Diabetes 3. Continuous Glucose Monitoring Frequency and Glycemic Control in People With Type 2 Diabetes – JAMA Network Open 4. An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program A Randomized Clinical Trial 5. Two-tier screening approach for liver fibrosis stratification in outpatients with type 2 diabetes mellitus: A multicenter cross-sectional study 6. Change in urine albumin-to-creatinine ratio and clinical outcomes in patients with chronic kidney disease and type 2 diabetes Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. For more information about each of ADA's science and medical journals, please visit Diabetesjournals.org. Hosts: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Walter Green is a remarkable philanthropist, mentor, author of This Is the Moment!, and founder of the impactful "Say It Now" movement. In this episode, Walter delves into the unique insights gained from his challenging upbringing, discusses embracing mortality, and highlights the mindset of "finishing strong." He shares insights on intentionality, thinking in reverse, saying "no," prioritizing relationships, and the essence of focusing on others. The conversation focuses on the "Say It Now" movement, which stresses the importance of expressing sentiments to loved ones well before the end of life. We discuss: How Peter and Walter met through Ric Elias [3:30]; The unique perspectives and life lessons provided by Walter's challenging childhood [6:00]; Walter's harrowing experience with a sudden mental breakdown and his subsequent recovery with the help of therapy [12:15]; A diverse professional journey ending in great success [19:15]; The birth of a movement: celebrating friendships through public tributes and expressing gratitude to those who have shaped your life's journey [23:30]; Intentionality, thinking in reverse, saying "no", and other guiding principles for Walter [30:45]; Walter's global journey of gratitude on his 70th birthday, visiting friends, and creating memorable experiences [40:15]; The profound impact of acknowledging and expressing gratitude for the people who contribute to our lives [47:15]; The key elements for creating meaningful connections and cultivating deep, authentic friendships [53:15]; The "Say It Now" movement: the inspiration behind the remarkably impactful initiative [59:15]; What "finishing strong" means to Walter [1:08:15]; Finding peace at the end of life through expressing gratitude and finding purpose in serving others [1:16:45]; Resources to learn about "Say It Now" [1:27:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
In today's episode, Tim Whitaker engages in a thought-provoking conversation with Josh Porter, author of 'How to Die: Chaos, Mortality, and the Scandal of Christian Discipleship.' They explore the complexities of Christian discipleship, the rejection of Christian nationalism, and the importance of inclusivity within the faith. Josh's Website | Joshuasporter.com Chapters 06:14 The Premise of 'How to Die' and Christian Discipleship 11:44 Navigating Christian Nationalism and Cultural Contexts 20:41 Understanding Christian Discipleship in Modern Times 27:52 The Complexity of Queer Inclusion in Christianity 34:13 Orthodoxy and the Evolution of Beliefs 51:43 Bringing Heaven to Earth: A Call to Action ____________________________________________________ TNE Podcast hosts thought-provoking conversations at the intersection of faith, politics, and justice. We're part of the New Evangelical's 501c3 nonprofit that rejects Christian Nationalism and builds a better path forward, rooted in Jesus and centered on justice. If you'd like to support our work or get involved, visit our website: www.thenewevangelicals.com Follow Us On Instagram @thenewevangelicals Subscribe On YouTube @thenewevangelicals This show is produced by Josh Gilbert Media | Joshgilbertmedia.com Learn more about your ad choices. Visit megaphone.fm/adchoices
How should we think about diets that claim to optimise both human and planetary health? Can a single "reference diet" really balance the complex trade-offs between nutrition adequacy, chronic disease prevention, and environmental sustainability? These questions have gained renewed attention with the release of the 2025 update to the EAT-Lancet Planetary Health Diet. The original 2019 report proposed a mostly plant-based dietary pattern designed to improve population health while staying within planetary boundaries. But since then, new data have emerged—on nutrient requirements, disease risk, and environmental modelling—that complicate many of the original assumptions. What does the updated evidence actually say about the health impacts of eating in line with this framework? How have the environmental projections changed? And what do these evolving targets mean for individuals, policymakers, and researchers trying to translate broad sustainability goals into practical dietary guidance? These are some of the questions explored in this episode of Sigma Nutrition, which examines the 2025 EAT-Lancet update, its scientific foundations, and what it reveals about the intersection of nutrition, health, and planetary sustainability. Timestamps [01:46] Focus on the 2025 EAT-Lancet report [02:27] Overview of the Planetary Health Diet [03:13] Comparing 2019 and 2025 reports [03:40] Dietary recommendations and nutrient targets [04:14] Health and environmental impacts [09:12] Scoring methods and dietary patterns [27:00] Mortality and chronic disease outcomes [40:01] Type 2 diabetes [44:13] Neuroimaging and cognitive outcomes [49:48] Conclusions and practical implications [58:55] Key ideas segment (Premium-only) Links & Resources Go to episode page (with links to studies) Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Alan Flanagan's Alinea Nutrition Education Hub Enroll in the next cohort of our Applied Nutrition Literacy course Report: EAT-Lancet
The description is in the title. Catch our drift?https://linktr.ee/jadeandxd
Darlene's childhood dream was to join the military. She didn't imagine she'd also be raising three children solo. Tune in to hear what it's like to be pregnant, breastfeed, and raise kids on your own in the Army. And to get shot in the back. Twice. ⭐️ This episode originally ran on March 7, 2016 and is a favorite from the archives. We hope you enjoy, and we'll be back next week with a brand new episode. … Recommendations from the archive #19 The Mortality of Motherhood … • Join LST+ for community and access to You Know What, another show in the Longest Shortest universe! • Follow us on Instagram • Sign up for our newsletter, where we recommend other parenting + reproductive health media • Buy books by LST guests (your purchase supports the show!) • Website: longestshortesttime.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Dan Houser is co-founder of Rockstar Games and is a legendary creative mind behind Grand Theft Auto (GTA) and Red Dead Redemption series of video games. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep484-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/dan-houser-transcript CONTACT LEX: Feedback - give feedback to Lex: https://lexfridman.com/survey AMA - submit questions, videos or call-in: https://lexfridman.com/ama Hiring - join our team: https://lexfridman.com/hiring Other - other ways to get in touch: https://lexfridman.com/contact EPISODE LINKS: Absurd Adventures: https://absurdventures.com A Better Paradise: https://www.amazon.com/exec/obidos/ASIN/B0FCYSK8VD American Caper: https://absurdventures.com/americancaper SPONSORS: To support this podcast, check out our sponsors & get discounts: Box: Intelligent content management platform. Go to https://box.com/ai UPLIFT Desk: Standing desks and office ergonomics. Go to https://upliftdesk.com/lex CodeRabbit: AI-powered code reviews. Go to https://coderabbit.ai/lex Miro: Online collaborative whiteboard platform. Go to https://miro.com/ Lindy: No-code AI agent builder. Go to https://go.lindy.ai/lex Shopify: Sell stuff online. Go to https://shopify.com/lex LMNT: Zero-sugar electrolyte drink mix. Go to https://drinkLMNT.com/lex OUTLINE: (00:00) - Introduction (01:29) - Sponsors, Comments, and Reflections (11:32) - Greatest films of all time (23:45) - Making video games (26:36) - GTA 3 (29:55) - Open world video games (32:42) - Character creation (36:09) - Superintelligent AI in A Better Paradise (45:21) - Can LLMs write video games? (49:41) - Creating GTA 4 and GTA 5 (1:01:16) - Hard work and Rockstar's culture of excellence (1:04:56) - GTA 6 (1:21:46) - Red Dead Redemption 2 (2:01:39) - DLCs for GTA and Red Dead Redemption (2:07:58) - Leaving Rockstar Games (2:17:22) - Greatest game of all time (2:22:10) - Life lessons from father (2:24:29) - Mortality (2:41:47) - Advice for young people (2:47:49) - Future of video games PODCAST LINKS: - Podcast Website: https://lexfridman.com/podcast - Apple Podcasts: https://apple.co/2lwqZIr - Spotify: https://spoti.fi/2nEwCF8 - RSS: https://lexfridman.com/feed/podcast/ - Podcast Playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 - Clips Channel: https://www.youtube.com/lexclips
The U.S. has a physician shortage, created in part by a century-old reform that shut down bad medical schools. But why haven't we filled the gap? Why are some physicians so unhappy? And which is worse: a bad doctor or no doctor at all? SOURCES:Karen Clay, professor of economics and public policy at Carnegie Mellon University.Rochelle Walensky, physician-scientist and former director of the CDC. RESOURCES:"Medical School Closures, Market Adjustment, and Mortality in the Flexner Report Era," by Karen Clay, Grant Miller, Margarita Portnykh, and Ethan Schmick (National Bureau of Economic Research, 2025)."Application Overload — A Call to Reduce the Burden of Applying to Medical School," by Rochelle Walensky and Loren Walensky (New England Journal of Medicine, 2025)."Challenges to the Future of a Robust Physician Workforce in the United States," by Rochelle Walensky and Nicole McCann (New England Journal of Medicine, 2025)."The first step to addressing the physician shortage," by Rochelle Walensky and Nicole McCann (STAT, 2025)."Physician Workforce: Projections, 2022-2037," (National Center for Health Workforce Analysis, 2024).“Projected Estimates of African American Medical Graduates of Closed Historically Black Medical Schools,” by Kendall Campbell, Irma Corral, Jhojana Infante Linares, and Dmitry Tumin (JAMA Network, 2020)."Medical Education in the United States and Canada," by Abraham Flexner (The Carnegie Foundation for the Advancement of Teaching, 1910). EXTRAS:"Is the Air Traffic Control System Broken?" series by Freakonomics Radio (2025)."Are You Ready for the Elder Swell?" by Freakonomics Radio (2025)."Are Private Equity Firms Plundering the U.S. Economy?" by Freakonomics Radio (2023). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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