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n one of the most emotional episodes of The Jimmy Rex Show, Jimmy sits down with entrepreneur, coach, and longtime friend Doug Cartwright just weeks after Doug was diagnosed with an aggressive glioblastoma brain tumor and given approximately 15 months to live.Doug shares the incredible story of how mysterious neurological symptoms led to an emergency brain surgery, the devastating diagnosis that followed, and why—despite facing death—he has found profound peace, gratitude, and purpose.Together they discuss mortality, spirituality, personal development, faith, love, AI-assisted medical research, experimental cancer treatments, and how embracing life fully changes everything when your time suddenly becomes uncertain.This is a conversation about far more than cancer—it's about how to truly live.Follow Doug Cartwright: IG
How can you enjoy sugar without gaining weight, fuelling cravings or crashing later in the day? The answer, surprisingly, is not to cut it out. In today's episode, Professor Tim Spector and Professor Sarah Berry discuss which forms of sugar affect your blood sugar levels most, and what small changes you can make today to reduce the impact. They also explore how sharp blood sugar spikes and dips may affect hunger, energy, inflammation and long-term health. By the end of the episode, you'll know how to spot hidden sugars, how to avoid the afternoon slump and energy crashes, and, most importantly, how to enjoy cake with less impact on your blood sugar. Sugar is not the enemy. But could a few small changes help you enjoy sweet foods without the cycle of cravings, hunger and energy crashes?
Frank LaRosa has been in this business for thirty-two years and he says he has never seen deals like this. Frank opens by explaining why he cannot see how financial advisor transition deals get any more lucrative than they are right now. Stacey backs that up with the numbers, pointing out that deals sitting at 100 percent of trailing twelve or 100 basis points today were only 40 or 50 just four or five years ago. That is not an opinion, it is math. From there, the conversation turns personal. Frank talks candidly about being in his mid-fifties and watching people his age face serious health scares or pass away without warning. That perspective drives his argument for why advisors with real practices should think seriously about taking chips off the table now, without selling their business, especially since transitions have become dramatically faster than they used to be. Frank also raises a fear a lot of advisors quietly carry, the worry that a new firm could eventually get acquired by the same company they left. Stacey breaks down why advisors still come out ahead in that scenario, since negotiating a move almost always comes with a lower cost of affiliation and a higher payout, meaning the money is already in the bank regardless of what happens years down the road. The episode wraps with a challenge Stacey poses directly, does your family or your spouse actually know about the decision you are making to stay put. Frank follows it up with a story from his branch manager days about closing deals over dinner with a recruit's spouse and why staying exactly where you are is still a decision that deserves a real conversation at home, not silence. Questions answered in this episode include: Why are financial advisor transition deals at an all-time high right now? What does it mean to take chips off the table without selling your practice? Why is choosing to stay at your current firm still considered a decision? Should advisors worry about their new firm getting acquired down the road? How fast can financial advisors realistically transition their book of business? Why do family conversations matter when deciding whether to move firms? Is complacency costing financial advisors real money right now? Chapters: 00:52 Introduction: This Market Won't Last Forever 02:54 Why Advisor Deals Are at an All-Time High 04:27 Mortality, Chips Off the Table and Taking Action Now 07:52 Choosing to Stay Is Still a Decision 10:58 The Risk-Reward Gap Advisors Are Ignoring 14:06 Your Head Is in the Sand 18:13 The Family Conversation Every Advisor Needs to Have 23:23 How to Reach Frank and Stacey Learn more about Elite and our resources: - Elite Consulting Partners: https://eliteconsultingpartners.com - Elite Marketing Concepts: https://elitemarketingconcepts.com - Elite Advisor Successions: https://eliteadvisorsuccessions.com - JEDI Database Solutions: https://jedidatabasesolutions.com - Elite Wealth Management Insights Report: https://eliteconsultingpartne
People spend over $36 billion a year on vitamins, and most people probably couldn't tell you what those nutrients are supposed to accomplish. The multivitamin is the most popular supplement on Earth, but it's also one of the most mocked and misunderstood, with one camp calling it a scam while another swears a special formulation changed their energy and their life. Both takes miss the point of what a multivitamin is designed to do. Inside today's episode, I settle the multivitamin conversation in a way you can take back to your own life, starting with the reframe that the multi is a cheap insurance policy against nutrient gaps rather than a hero or a villain.Topics discussed: - Multivitamin as Insurance Policy- Vitamin D, Magnesium, and the Nutrient Gap Data- Why the RDA Is a Floor Not a Target- The Cheap Forms Problem- Nutrient Competition Inside the Pill- The Multivitamin Mindset Trap- What the Research Shows on Mortality and Disease- The Five Groups Who Benefit Most---------- My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization www.metabolismschool.com---------- [Free] Metabolism School 101: The Video Serieshttp://www.metabolismschool.com/metabolism-101----------Subscribe to My Youtube Channel: https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1----------Grab a Copy of My New Book - Metabolism Made Simple---------- Stay Connected: Instagram: @sammillerscienceYoutube: SamMillerScience Facebook: The Nutrition Coaching Collaborative CommunityTikTok: @sammillerscience----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at operations@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."
SPONSORS: 1) AMENTARA: Go to amentara.com/go/julian and use Code: JDP22 for 22% off your first purchase. 2) MOOD: Get 20% off your first order of federally legal cannabis gummies, flower, and more at https://mood.com with promo code JULIAN. 3) DOSE: Head to dosedaily.co/JULIAN or enter JULIAN to get 35% off your first subscription. JOIN PATREON FOR EARLY UNCENSORED EPISODE RELEASES: https://www.patreon.com/JulianDorey CLIPPERS DISCORD: https://discord.gg/8QmWEKJ3BT (***TIMESTAMPS in Description Below) ~ Joe Kent is an American politician, former United States Army warrant officer, and former Central Intelligence Agency paramilitary officer who served as the director of the National Counterterrorism Center from 2025 to 2026. JOE's LINKS - X: https://x.com/joekent16jan19 - IG: https://www.instagram.com/joekent16jan19/?hl=en - BOOK: https://shorturl.at/PS195 FOLLOW JULIAN DOREY INSTAGRAM (Podcast): https://www.instagram.com/juliandoreypodcast/ INSTAGRAM (Personal): https://www.instagram.com/julianddorey/ X: https://twitter.com/julianddorey JULIAN YT CHANNELS - SUBSCRIBE to Julian Dorey Clips YT: https://www.youtube.com/@juliandoreyclips - SUBSCRIBE to Julian Dorey Daily YT: https://www.youtube.com/@JulianDoreyDaily - SUBSCRIBE to Best of JDP: https://www.youtube.com/@bestofJDP ****TIMESTAMPS**** 0:00 - Resignation Over Israel 10:41 - Fatherhood, Grief & Trump 22:22 - Trump, Iran & Tulsi Gabbard 31:35 - Midnight Hammer & Netanyahu's Influence 44:06 - Venezuela & Israel's Secret Plan 58:35 - Petrodollar & Intelligence Atrophy 1:04:31 - Foreign Money Buying American Policy 1:15:00 - Petrodollar, Sanctions & Trump MOU 1:25:35 - Hot War & Restraining Israel 1:34:50 - Butler Assassination & FBI Failures 1:44:30 - Ayatollah Assassination Intent & Government Rot 1:54:35 - Mossad, CIA & JD Vance 2:04:37 - Vance, Rubio & the Dead MOU 2:14:30 - Energy Crisis & King of Jordan 2:24:35 - China, Saudis & Iran Going Nuclear 2:34:30 - Nukes, ISIS, Syria & Turkey 2:44:30 - Green Berets, Rangers & 9/11 Reality 2:54:38 - Baghdad, Saddam's Nukes & Combat Truth 3:03:56 - Mortality, Fatherhood & Iraqi Sentiment 3:14:40 - Al Qaeda & How We Created Terrorists 3:28:00 - Yemen, Combat & His Late Wife 3:40:00 - Syria, Suicide Bomber & Grief 3:44:30 - CIA Paramilitary & Africa Deployment 3:54:40 - Tulsi, JFK Files & Epstein 4:03:10 - Epstein, CIA & Ukraine War 4:11:31 - Kirk Assassination & FBI Tension 4:15:19 - Joe's Work CREDITS: - Host, Editor & Producer: Julian Dorey - COO, Producer & Editor: Alessi Allaman - https://www.youtube.com/@UCyLKzv5fKxGmVQg3cMJJzyQ - In-Studio Producer: Joey Deef Julian Dorey Podcast Episode 452 - Joe Kent Music by Artlist.io Learn more about your ad choices. Visit podcastchoices.com/adchoices
Our Lead Pastor, Whit George, continues week seven of our teaching series, Summer in the Psalms.
What if our obsession with “dangerous” sun is killing us?If you (recklessly) leave your urban office for lunch, you are told to yank your hat down low. If you (again, recklessly) let your kids dash into the backyard, you are told to slather them in sunscreen—or learn to live with the guilt.And yes, sun avoidance undoubtedly prevents some skin cancers, including the deadliest type, melanomaBut a recent study suggests sunlight contributes to hundreds of thousands of deaths every year in the United States alone—orders of magnitude more than the estimated 8400 annual US melanoma deaths.In this episode, we discuss evidence linking sun avoidance toalmost a million annual deaths in the US and Europe alone, exceeding the number caused by global military conflictsbreast, pancreatic, colon, and lung cancers, as well as heart disease, high blood pressure, and stroketo INCREASED risk of death in those diagnosed with sun-induced melanoma.Yes, you read that right; some melanoma deaths may be related to too little sunlight. (But do understand that this is complex--sunlight DOES cause melanoma. Well, some melanomas....)We also discuss why supplementing with vitamin D pills fails to remedy these terrible conditions, and what a thoughtful person can do instead, while staying safe.We hope you enjoy this episode, and that it helps you enjoy the sun again--thoughtfully, of course. References and further reading: Sunlight: Time for a Rethink?Benefits of oral Polypodium leucotomas extract in MM high risk patients (This is an ingredient in Life Extension's Shade Factor, mentioned in this episode by Dr. Gordon). Uses of Polypodium leucotomos Extract in Oncodermatology Calzari et alInsufficient Sun Exposure Has Become a Real Public Health Problem. Alfredsson L, Armstrong BK, Butterfield DA, et al. International Journal of Environmental Research and Public Health. 2020;17(14):E5014. doi:10.3390/ijerph17145014.Prospective Study of Ultraviolet Radiation Exposure and Risk of Cancer in the United States. Lin SW, Wheeler DC, Park Y, et al. International Journal of Cancer. 2012;131(6):E1015-23. doi:10.1002/ijc.27619.An Estimate of Premature Cancer Mortality in the U.S. Due to Inadequate Doses of Solar Ultraviolet-B Radiation. Grant WB. Cancer. 2002;94(6):1867-75. doi:10.1002/cncr.10427.Solar Ultraviolet-B Exposure and Cancer Incidence and Mortality in the United States, 1993-2002. Boscoe FP, Schymura MJ. BMC Cancer. 2006;6:264. doi:10.1186/1471-2407-6-264.Ecological Studies of the UVB-vitamin D-Cancer Hypothesis. Grant WB. Anticancer Research. 2012;32(1):223-36.Sunlight Exposure in Association With Risk of Lymphoid Malignancy: A Meta-Analysis of Observational Studies. Kim HB, Kim JH. Cancer Causes & Control : CCC. 2021;32(5):441-457. doi:10.1007/s10552-021-01404-6.Adulthood Residential Ultraviolet Radiation, Sun Sensitivity, Dietary Vitamin D, and Risk of Lymphoid Malignancies in the California Teachers Study. Chang ET, Canchola AJ, Cockburn M, et al. Blood. 2011;118(6):1591-9. doi:10.1182/blood-2011-02-336065.Is Prevention of Cancer by Sun Exposure More Than Just the Effect of Vitamin D? A Systematic Review of Epidemiological Studies. van der Rhee H, Coebergh JW, de Vries E. European Journal of Cancer (Oxford, England : 1990). 2013;49(6):1422-36. doi:10.1016/j.ejca.2012.11.001.An Ecologic Study of Cancer Mortality Rates in Spain With Respect to Indices of Solar UVB Irradiance and Smoking. Grant WB. International Journal of Cancer. 2007;120(5):1123-8. doi:10.1002/ijc.22386.Does Sunlight Prevent Cancer? A Systematic Review. van der Rhee HJ, de Vries E, Coebergh JW. European Journal of Cancer (Oxford, England : 1990). 2006;42(14):2222-32. doi:10.1016/j.ejca.2006.02.024.Heliovaccination: Solar mediated immunity against cancer. Uzoigwe CE. Experimental Dermatology. 2020;29(5):477-480. doi:10.1111/exd.14087.Beneficial Health Effects of Ultraviolet Radiation: Expert Review and Conference Report. Riedmann U, Dibben C, de Gruijl FR, et al. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. 2025;24(6):867-893. doi:10.1007/s43630-025-00743-6.A Blueprint for the Primary Prevention of Cancer: Targeting Established, Modifiable Risk Factors. Gapstur SM, Drope JM, Jacobs EJ, et al. CA: A Cancer Journal for Clinicians. 2018;68(6):446-470. doi:10.3322/caac.21496.Proportion and Number of Cancer Cases and Deaths Attributable to Potentially Modifiable Risk Factors in the United States, 2019. Islami F, Marlow EC, Thomson B, et al. CA: A Cancer Journal for Clinicians. 2024 Sep-Oct;74(5):405-432. doi:10.3322/caac.21858.Cutaneous Melanoma. Joshi UM, Kashani-Sabet M, Kirkwood JM. JAMA. 2025;334(23):2113-2125. doi:10.1001/jama.2025.13074.Sunlight, Vitamin D and the Prevention of Cancer: A Systematic Review of Epidemiological Studies. van der Rhee H, Coebergh JW, de Vries E. European Journal of Cancer Prevention : The Official Journal of the European Cancer Prevention Organisation (ECP). 2009;18(6):458-75. doi:10.1097/CEJ.0b013e32832f9bb1.Lessons Learned From Paleolithic Models and Evolution for Human Health: A Snap Shot on Beneficial Effects and Risks of Solar Radiation. Reichrath J. Advances in Experimental Medicine and Biology. 2020;1268:3-15. doi:10.1007/978-3-030-46227-7_1.PS-Vitamin D. American Academy of Dermatology (2022).American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer With Healthy Food Choices and Physical Activity. Kushi LH, Byers T, Doyle C, et al. CA: A Cancer Journal for Clinicians. 2006;56(5):254-81; quiz 313-4. doi:10.3322/canjclin.56.5.254.Vitamin D, Sunlight and Cancer Connection. Holick MF. Anti-Cancer Agents in Medicinal Chemistry. 2013;13(1):70-82.Survivorship. National Comprehensive Cancer Network. Updated 2026-04-08.Keratinocyte Carcinoma. Wehner MR. JAMA. 2025;:2840731. doi:10.1001/jama.2025.18749.Public Awareness and Behaviour in Great Britain in the Context of Sunlight Exposure and Vitamin D: Results From the First Large-Scale and Representative Survey. Burchell K, Rhodes LE, Webb AR. International Journal of Environmental Research and Public Health. 2020;17(18):E6924. doi:10.3390/ijerph17186924.Behavioral Counseling to Prevent Skin Cancer: US Preventive Services Task Force Recommendation Statement. US Preventive Services Task Force, Grossman DC, Curry SJ, et al. JAMA. 2018;319(11):1134-1142. doi:10.1001/jama.2018.1623.Lifetime Sunburn Trajectories and Associated Risks of Cutaneous Melanoma and Squamous Cell Carcinoma Among a Cohort of Norwegian Women. Lergenmuller S, Rueegg CS, Perrier F, et al. JAMA Dermatology. 2022;158(12):1367-1377. doi:10.1001/jamadermatol.2022.4053.Cancer Prevention and Early Detection Facts & Figures. Rick Alteri, Deana Baptiste, Emily Butler Bell, et al. American Cancer Society (2025). Skin Cancer, Irradiation, and Sunspots: The Solar Cycle Effect. Valachovic E, Zurbenko I. BioMed Research International. 2014;2014:538574. doi:10.1155/2014/538574.Intense Solar Activity Reduces UrinarDawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains
The JournalFeed podcast for the week of July 13-17, 2026.These are summaries from just 2 of the 5 articles we cover every week! For access to more, please visit JournalFeed.org for details about becoming a member.Thursday's Spoon Feed:Hypothermia found during emergency department triage is a strong, independent predictor of in-hospital death among children.Friday's Spoon Feed:This hypothesis-generating study showed that maintaining EMS pads and equipment during ED transfer for out-of-hospital cardiac arrests (OHCA) saved 143 seconds to first rhythm analysis and defibrillation.
Book a call with Travis: https://calendly.com/travis-eib/30-minute-callBook a call: https://remnantfinance.com/calendarOut Print the Fed with a 1% target per week: https://remnantfinance.com/optionsEmail us at info@remnantfinance.com or visit https://remnantfinance.com for more informationFOLLOW REMNANT FINANCEYoutube: @RemnantFinance (https://www.youtube.com/@RemnantFinance)Facebook: @remnantfinance (https://www.facebook.com/profile.php?id=61560694316588)Twitter: @remnantfinance (https://x.com/remnantfinance)TikTok: @RemnantFinanceDon't forget to hit LIKE and SUBSCRIBEIn this episode, Hans welcomes back Travis McBride, a former Navy helicopter pilot turned insurance professional, for his third appearance and a conversation about annuities, guaranteed lifetime income, and why the order of your returns matters more than the average. Fresh off the birth of his son, Travis opens up about how fatherhood reframes the way he thinks about mortality and protecting the people who depend on you.From there they get into sequence of return risk, including a live demo where shuffling the exact same 30 years of returns swings the outcome from $2.2 million left over to fully broke in 14 years, and why a guaranteed income floor lets you stay on the compounding curve right when it's most powerful.Chapters:00:00 – Opening segment03:10 – Re-anchoring on why we plan: it's about the next generation05:25 – Why $500K of SGLI won't set a family up10:15 – What an annuity actually is: the inverse of life insurance14:40 – The power of setting an income floor18:30 – A brief history of annuities, from Rome to the modern pension gap20:15 – When to consider an annuity: the 50 to mid-70s window21:15 – No medical underwriting: annuities are priced on age alone25:15 – The 4% rule and where it falls apart26:05 – Sequence of return risk explained with a live shuffle28:45 – Same data, wildly different outcomes30:50 – Why the Series 65 teaches nothing about insurance or annuities35:00 – Trade-offs exist everywhere, even in a Roth IRA and 401(k)39:50 – Mortality credits: the third form of return45:30 – Payouts are tied to the 10-year Treasury at purchase46:40 – The 1035 exchange: upgrading an old, uncompetitive annuity50:00 – Closing segmentKey Takeaways:The order of your returns can matter more than the returns themselves. Take the same 30 years of market data and simply shuffle the sequence, and the outcome swings from leaving $2.2 million behind to running out of money in 14 years.An annuity is the inverse of life insurance, and it's the only chassis that guarantees income for life. Where a $1 million portfolio using the 4% rule cautiously pulls $40,000 a year and still might run dry, that same $1 million can buy a fully guaranteed $77,000 a year that keeps paying as long as you're alive.A guaranteed income floor buys you flexibility everywhere else. Once your baseline needs are covered for life, you no longer have to run conservative with the rest of the portfolio.$500K of group life insurance is not a plan. In a high cost of living area, half a million won't maintain a family's lifestyle, and most people aren't even capped out there.If your parents bought an annuity, get it reviewed. Payouts are locked to the 10-year Treasury yield at the time of purchase, so annuities bought in low-rate years are often badly uncompetitive today.
This episode is a replay from The Existential Stoic library. Enjoy! Are you experiencing an existential crisis? You might feel lost, anxious, depressed, and/or hopeless. Danny and Randy discuss how to overcome an existential crisis. Check out the Cleveland Clinic's article featured in this episode: https://health.clevelandclinic.org/ways-to-overcome-an-existential-crisis/Subscribe to ESP's YouTube Channel! Thanks for listening! Do you have a question you want answered in a future episode? If so, send your question to: existentialstoic@protonmail.com
In this edition of The Random Show, Tim Ferriss and Kevin Rose reunite over tequila to talk Zen retreats, learning to rock climb at (almost) 50, mortality and grief, why you should stop saying "one day," AI predictions , and much more. Please enjoy!This episode is brought to you by:Incogni, which removes your personal data from the web, helping shield you from fraud, scams, and identity theft: Incogni.com/Tim (use code TIM at checkout and get 60% off an annual plan)Wealthfront high-yield cash account: Wealthfront.com/Tim New clients get 3.30% base APY from program banks + additional 0.75% boost for 3 months on your uninvested cash (max $150k balance). Terms and conditions apply. The Cash Account offered by Wealthfront Brokerage LLC (“WFB”) member FINRA/SIPC, not a bank. The base APY as of 1/30/26 is representative, can change, and requires no minimum. Tim Ferriss, a non-client, receives compensation from WFB for advertising and holds a non-controlling equity interest in the corporate parent of WFB, which creates a conflict of interest. Individual experiences and outcomes will differ. Instant withdrawals may be limited by your receiving firm and other factors. Investment advisory services provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, not bank-guaranteed or FDIC-insured, and may lose value.Timestamps[00:00:00] Start.[00:00:24] A tequila toast, and getting "taxed" by alcohol as you age.[00:02:18] Toaster at 15: a late-night health scare.[00:06:01] Losing Om Malik, and finding out on retreat.[00:08:03] Matt Mullenweg, Antarctica, and gratitude.[00:09:34] Coming to terms with our limited time on Earth.[00:14:37] Five days of silence and the koan "Mu."[00:15:20] Kevin's micro-insight and a plug for The Way.[00:27:25] Rock climbing after 40, and a Yosemite goal.[00:29:18] Michael Eckert and finger-strength training.[00:30:40] The Nug, Abrahangs, and a travel training kit.[00:32:57] Free Solo and climbing with a fear of heights.[00:37:53] The Blade Itself, and a friend lost in a plane crash.[00:39:19] A2 protein and Pioneer Pastures.[00:40:34] Maui Nui venison and the nitrate question.[00:43:48] deltaG ketones: what they are and the catch.[00:45:42] Ketones, dementia, and verbal fluidity.[00:46:29] Pre-grieving a parent's decline.[00:48:33] Training not to die: the one bike I can stand and the Norwegian 4×4.[00:51:10] Something beats nothing: saunas, treadmills, and Duolingo chess.[00:53:04] The MM120 anxiety study — and a small-world surprise.[00:56:17] Psilocybin, LSD, and dementia case reports.[01:01:28] Neutonic toothpicks and Kevin's AI-powered home.[01:06:12] Spooky AI personalization and investment autopsies.[01:17:38] Values cards, contractual bonds, and dark information.[01:23:25] 360 reviews and child-rearing.[01:24:54] Wispr Flow, Shokz, and my recording rig.[01:29:32] The "big three" and where AI goes next.[01:44:40] Let your winners run; buy the company, not the product.[01:51:08] Digg's relaunch, 5-Bullet Friday, and parting thoughts.*DISCLAIMER FROM TIM FERRISS: I am not an investment adviser. Nor is Kevin Rose. All opinions are mine alone. Or his. There are risks involved in placing any investment in securities or in Bitcoin or in cryptocurrencies or in anything. None of the information presented herein is intended to form the basis of any offer or recommendation or have any regard to the investment objectives, financial situation, or needs of any specific person, and that includes you, my dear listener or reader. Everything you're going to hear is for informational entertainment purposes only.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Why Oral and IV Glutathione Never Actually Reach Your Cells (The Delivery Breakthrough Changing Everything) Most of the supplements you're taking aren't failing you, they're failing to ever reach the cells that need them, and almost nobody selling them wants you to know that. This episode hands you the delivery breakthrough that actually gets it there. Use code DAVE for a discount at aurowellness.com/dave Host Dave Asprey sits down with Dr. Nayan Patel, a pharmacist, researcher, and founder of Auro Wellness, whose work centers on solving one of biohacking's most stubborn problems: getting nutrients past the bloodstream and into the cells that actually need them. He holds 14 patents in delivery technology, partners in the high-end longevity clinic Unlimited Life, and has spent over two decades studying glutathione, the master antioxidant his own research helped bring into modern biohacking. Dave and Dr. Patel break down a 2011 University of Texas study showing that oral and liposomal glutathione are completely broken down into raw amino acids before absorption, meaning none of it reaches the bloodstream as glutathione, a pattern that holds true even for IV administration. They dig into new brain-imaging research showing topical glutathione crossing into neural tissue within 20 minutes, why senescent "zombie cells" may be directly tied to glutathione shortfalls, and why NAD, despite its reputation as the ultimate longevity molecule, is actually dependent on glutathione to do its job. They also cover the real purity ceiling on GHK-copper peptides, safe upper limits for glycine and NAC before they start working against you, a topical alcohol protocol that clears acetaldehyde without triggering a breathalyzer, and why oxidative stress from GLP-1 use is quietly driving one of the drug class's least-discussed side effects. You'll Learn: Why oral, liposomal, and even IV glutathione never actually reach your cells intact, and what a 2011 UT study proved about it How topical glutathione was shown to cross into brain tissue within 20 minutes, and what that means for neurological aging Why senescent "zombie cells" may be directly linked to glutathione shortfalls, and how one longevity clinic reversed markers by 70% in a year Why NAD isn't the "ultimate longevity drug" it's marketed as, and its actual dependent relationship with glutathione The real purity ceiling on GHK-copper peptides, and why 73% is currently the best available anywhere Safe upper limits for glycine and NAC, and the oxalate crystal and Parkinson's-like risks of overdoing either one A topical alcohol protocol that clears acetaldehyde fast enough to beat a breathalyzer Why GLP-1 drugs are quietly driving oxidative stress, and what most patients are missing to counter it Thank you to our sponsors! - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE #oneskinpod - Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order. - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com and using code DAVE at checkout Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: glutathione, Nayan Patel, Ora Wellness, glutathione absorption, transdermal delivery, senescent cells, zombie cells, cellular aging, GHK-copper peptide, NAD, NAD supplements, NAC, glycine, GlyNAC, oxalate crystals, alcohol metabolism, acetaldehyde, GLP-1, semaglutide, oxidative stress, heavy metal detox, mercury toxicity, BPC-157, biohacking, longevity, functional medicine Resources: • Get A Discount On Auro Wellness Products - Use code DAVE: aurowellness.com/dave • Learn More About Dr. Patel's work at: http://aurowellness.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:43 – Episode Intro 03:16 – Glutathione Basics 07:34 – Senescent Cells 11:07 – Cellular Delivery Science 14:20 – GlyNAC Precursors 21:37 – Amino Acid Ratios 25:18 – GHK Copper Peptide 28:41 – Purity & Manufacturing 31:34 – Glutathione vs. NAD 33:49 – Absorption Studies 37:51 – Heavy Metals & Toxins 42:35 – Alcohol & Glutathione 47:43 – Mortality & Reincarnation 49:54 – GLP-1s & Anhedonia 53:25 – Future of Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Six days before he sat down for this conversation, he ran a marathon. Then he explained what the race did to his brain. When you run 26 miles and your glycogen runs out, your brain still needs energy, so it starts stripping the fatty myelin off its own neurons and burning it for fuel. MRI scans caught a 20% drop in myelin up to two months after a marathon, and cognitive testing showed real impairment for about a month. In this episode, Louisa sits down with Brady Holmer, exercise physiologist, 2:24 marathoner, and author of VO2 Max Essentials, for one of the most practical conversations on aerobic fitness, brain health, and longevity the show has recorded. They cover why "marathon brain" is real but temporary, the menopause parallel where a starved brain catabolizes its own white matter, and whether pre-loading ketones or omega-3s can protect your myelin through a hard endurance effort. Then Brady breaks down VO2 max the way almost nobody does: not as a heart-and-lung number, but as a five-step oxygen cascade running from your lungs to your mitochondria, and why the bottleneck moves from your heart to your muscles as you age. You will learn the exact VO2 max floor below which everything becomes a maximal effort, the "50 at 50" target, and why women should aim for 40 to 50. Brady also lays out how the brain itself gates your fitness through myokine signaling, why the one to two hours after training may matter more than sleep for adaptation, and the truth about "non-responders" and the IGF binding protein biology behind trainability. Then the protocols: why the Norwegian 4x4 beats Tabata for VO2 max, how sauna and post-exercise ketones amplify the same session, why sleep consistency beats sleep duration, and the single weekly workout Brady says everyone should be doing for both VO2 max and brain health over the next decade. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. TOPICS DISCUSSED 00:00 Intro: Marathon Brain and the Number That Predicts How Long You Live 00:40 Does Running a Marathon Really Damage Your Brain? 01:04 The Study: 20% Myelin Loss on MRI After a Marathon 02:16 Impaired Cognition for a Month, Then Full Recovery 03:28 Why It Happens: The Brain Burns Its Own Myelin for Fuel 04:44 The Menopause Parallel: Brain Glucose Starvation and White Matter 05:57 Can Ketones and BHB Protect the Brain During a Marathon? 06:42 How Marathon Runners Should Fuel to Protect Cognition 08:22 VO2 Max: The Strongest Predictor of Mortality and Longevity 09:00 The Oxygen Cascade: What VO2 Max Actually Measures 11:08 Why VO2 Max Matters More As You Age 12:10 The VO2 Max Floor for Frailty and Daily Living 13:11 VO2 Max as a Brain Metric: Averages by Age and Sex 14:20 The "50 at 50" Target and What Women Should Aim For 15:09 The Female Masters Athlete Study and the VO2 Max Bank Account 16:01 How Your Brain Knows It Is Getting Fitter: Myokines 17:41 Mouse Studies: Block the Brain Signal, Lose the Adaptation 18:37 The Post-Workout Recovery Window That Drives Adaptation 19:53 What Kind of Rest Actually Works After Training 20:50 KetoneIQ: Clean Fuel for the Brain 21:50 Qualia Magnesium: Recovery and Deep Sleep 22:45 The Mission: Why Science Is the New Breaking News 27:25 Attacking VO2 Max From a Different Angle: What Is Your Bottleneck? 28:06 Central vs Peripheral: Heart, Muscle, and Mitochondria 30:20 Spotting Mitochondrial Dysfunction With a Simple Lactate Test 33:18 Training Each Link in the Oxygen Cascade 34:41 Targeting the Lungs: Inspiratory Muscle Training 36:19 Iron, Hemoglobin, and Heat as an Altitude Mimic 38:56 Exercise Hemolysis: Why Runners Break Down Red Blood Cells 39:59 Why Investors and CEOs Are Chasing VO2 Max 40:42 What Is Good for the Heart Is Good for the Brain 42:02 Exercise Snacks vs Deliberate Training as You Age 44:41 HIIT for Stroke Volume: Why the Norwegian 4x4 Works 45:43 4x4 vs Tabata and the 2 to 8 Minute Interval Sweet Spot 46:57 Using Heart Rate and Exertion to Train VO2 Max 48:02 Where AI Is Entering Endurance Coaching 49:14 Timeline Mitopure: Powering Your Mitochondria 50:16 Cozy Earth: Better Bedding, Better Sleep 51:04 Responders vs Non-Responders and the IGFBP Biology 55:35 How to Amplify Adaptation From the Same Training Load 56:39 Heat, Post-Exercise Ketones, and Getting the Basics Right 58:14 Sleep Consistency Beats Sleep Duration 01:00:24 The One Weekly Workout for VO2 Max and Brain Health Thank you to our sponsors KetoneIQ: https://ketone.com/NEURO for 30% OFF Qualia: https://qualialife.com/NEURO for 50% off Timeline: https://timeline.com/NEURO for Mitopure Cozy Earth: https://cozyearth.com use code NEURO for 20% off I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices
**[Inspiring]**We are absolutely thrilled to share this outstanding and thought-provoking exposition on one of the most pivotal and revealing subjects in all of Scripture: the true nature of the Devil and Satan. As Christadelphians, we are committed to a careful, verse-by-verse examination of God's Word, and this chapter—Chapter 16 from our series on what we believe and preach—offers a wonderfully insightful look at a topic that is so often misunderstood.This presentation is a wonderful journey through the New Testament, guided by the original Greek and Hebrew, to uncover the real meaning behind the words *diabolos* and *Satan*. We explore the profound and often-overlooked truth that the Old Testament is completely silent on a personal, supernatural devil, and that the emphasis of the New Testament points us to a powerful, revelatory conclusion: the devil is the personification of human sinfulness, the lusts of the flesh, and the corporate wickedness of the world.Join us as we trace this compelling thread through Scripture, from the temptation in the wilderness to the ultimate victory of Christ. We examine how Jesus, by partaking of flesh and blood, destroyed him that had the power of death—that is, the devil—and how His sinless life broke the power of sin and opened the way to salvation. This is a truly inspiring and clarifying study that will strengthen your understanding of the Gospel and the nature of the battle we all face.---###
In this episode of See See by Ceci, Dr Stephen Cave, philosopher of technology, intelligence and the human quest to outlive death, joins us in our Berlin studio. At heart, this episode turns on two questions most of us would sooner leave undisturbed: why do human beings insist on ranking one another, and why can we not make our peace with the fact that we die? Academic Director of the Leverhulme Centre for the Future of Intelligence and Co-Director of the Institute for Technology and Humanity, both at the University of Cambridge, Dr Cave took his PhD in philosophy at Cambridge before spending the better part of a decade as a British Foreign Office diplomat. He is the author of Immortality: The Quest to Live Forever and How It Drives Civilization, a New Scientist Book of the Year, and, with the philosopher John Martin Fischer, Should You Choose to Live Forever?: A Debate. He is also co-editor of AI Narratives, Imagining AI and Feminist AI, all published by Oxford University Press. In this wide-ranging conversation, Dr Cave traces the idea of "intelligence" across two and a half thousand years, from Aristotle's "natural slaves" to Francis Galton's invention of both eugenics and the IQ test, showing how so slender a concept came to serve as the perfect instrument for justifying patriarchy, colonialism and scientific racism. It is precisely this buried history, he argues, that explains the dread super-intelligent machines now inspire in us. The real peril, he suggests, lies not in what artificial intelligence might do to us, but in the deep-seated biases and failings already entrenched our societies, that is, in what we might be tempted to do to one another with it: in surveillance, in the automation of labour, and, above all, in the quiet erosion of the human relationships that hold a society together and lend our lives their meaning. He then turns to mortality: the four stories every civilisation tells itself to outwit death, why a genuine immortality would prove a curse rather than a gift, and how our very finitude is the thing that makes a life worth living. From the Epic of Gilgamesh to Borges's deathless troglodytes, from Dorian Gray to the laboratories where great fortunes are now spent in pursuit of longer life, he asks what such a life is truly worth if it is not also a life of meaning, and warns that "work, scroll, repeat" is no less hollow at two hundred than at eighty. He arrives, in the end, at something disarmingly simple: an answer that has rather less to do with intelligence than we might expect, and everything to do with finitude, and with what, and whom, a life is spent upon. With reflections from the philosopher and cognitive scientist Paul Thagard on whether a machine can ever truly care; from the posthumanist scholar N. Katherine Hayles on the human aura in the age of the deep fake and the promised revision of the Enlightenment; from the drummer, composer and Berklee professor Terri Lyne Carrington on music and the eternal present; from the historian Philip Matyszak on the Roman afterlife and the building of "moral muscles"; and from the cognitive neuropsychologist Alfonso Caramazza on the remarkable flexibility of the human mind. This is an episode about power and the stories it tells to justify itself; about the older stories we tell to cheat death; and about a quiet, radical proposition: that to be human is not to be the cleverest thing in the room, but to know that our days are numbered, and to spend them building and delighting in our bonds with one another.
Summary In this episode, Andy sits down with Tom Rath, one of the most respected researchers on wellbeing and human potential, author of What's the Point? Turning Your Purpose Into a Superpower. Tom argues that we can be incredibly busy while slowly drifting away from what matters most, optimizing our schedules while our lives quietly leak away. Andy and Tom explore why "follow your passion" can be harmful advice, how status seeking becomes career quicksand, and why our smartphones may be one of the greatest threats to purposeful living. They also discuss how many of us inherit ambitions from our parents that we never consciously chose, and how an honest awareness of mortality can sharpen our clarity, intentionality, and sense of purpose. Rather than treating purpose as one grand calling, Tom reframes it as something we create in small moments throughout the day. If you're looking for a practical, and honestly a little uncomfortable, guide to leading and living with more purpose, this episode is for you! Sound Bites "Here's what I know with absolute certainty: you're wasting most of your day. Not because you're lazy, but because you've never asked the right question. You're so busy being busy that you've forgotten to ask why. You're optimizing your schedule while your life leaks away, hour by hour in meetings that don't matter and tasks that won't be remembered next week, let alone next year." "If you fail to do those things in a day and take that initiative and have those meaningful and purposeful conversations, and you put those off until tomorrow, tomorrow never really comes because we get into that responsive mode." "Passion by definition starts with you, and it's a little self-oriented, whereas I would argue purpose by definition has an other orientation to it, which is a much better idea for anchoring your energy in a day." "If you're not connecting back with the impact that it made on one person that day, it fails to kind of count in the way we motivate ourselves and think about our work on a daily basis." "I would argue that 90% of the purpose in life is built in those moments, not in some epiphany on a sunny day." "I would estimate that at least 80% of people, maybe 90%, make it all the way to the very end of their career in their life without ever seeing what they could have been best at in life." "Even as managers and leaders, if we don't take care of our own health and wellbeing first, we just have no shot at even being our best for other people that we manage." "There's always someone making twice as much as you or 10 times as much as you, and there's always somebody with more followers or more listeners or more readers or whatever it might be." "The eulogy virtues are about what am I doing today so I'll be a better dad, a better husband, a better friend, to help readers, to help people with the products I'm working on." "I would argue that 80% of people I see out in public today, out in the wild, are essentially working for their smartphone." "Their smartphone's running their life, and they're the ones salivating like one of Pavlov's dogs every time the darn thing blinks or buzzes or vibrates, right?" "Having your phone out sends an implicit message to the other person that the little black box on the table matters more than the other person, and it degrades the quality of the conversation." "The one thing we've all got in common is we have today to try and do some things that serve a purpose and help another person, and if you miss that opportunity, it's gone." "None of them, none of the headstones say anything about those kind of resume virtues that we were talking about." Chapters 00:00 Introduction 02:00 Start of Interview 02:08 Busy, Yet Drifting from What Matters 05:50 Rethinking the "One True Calling" 07:38 Why "Follow Your Passion" Can Backfire 09:26 From "What Do I Do?" to "Who Do I Help?" 11:20 How Our Parents' Paths Shape Us 12:11 When Admirable Influence Becomes a Limiting Script 15:01 Unlearning the "Always the Hardest Worker" Mindset 16:55 Are We Nudging Our Kids Into Our Dreams? 19:23 Status Seeking as Career Quicksand 22:02 Choosing Your Own Scoreboard 23:38 Smartphones and the Threat to Purpose 26:28 Making Technology Work for You 28:05 How Mortality Sharpens Purpose 30:52 What the Headstones Don't Say 32:33 Helping Kids Build Lives That Matter 35:21 End of Interview 35:48 Andy Comments After the Interview 40:20 Outtakes Learn More You can learn more about Tom and his new book at tomrath.org/whats-the-point. For more learning on this topic, check out: Episode 132 with Tom Rath. An earlier conversation with Tom, digging into his story and his research on wellbeing. Episode 140 with Tom Rath. Another previous discussion with Tom on wellness and living with strengths. Episode 31 with Adam Grant. Adam's first-ever podcast interview, where he shares insights on how to lead with meaning. Episode 261 with David Epstein. A conversation about his book Range, a helpful complement on career decisions for kids and for us. Chat with PMeLa You can chat directly with PMeLa—the podcast's AI persona—to get episode recommendations and answers to your project management and leadership questions. Visit PeopleAndProjectsPodcast.com/PMeLa to chat with her. Join Us for LEAD52 I know you want to be a more confident leader–that's why you listen to this podcast. LEAD52 is a global community of people like you who are committed to transforming their ability to lead and deliver. It's 52 weeks of leadership learning, delivered right to your inbox, taking less than 5 minutes a week. And it's all for free. Learn more and sign up at GetLEAD52.com. Thanks! Thank you for joining me for this episode of The People and Projects Podcast! Talent Triangle: Business Acumen Topics: Purpose, Leadership, Career Development, Passion, Wellbeing, Intentionality, Status, Comparison, Digital Distraction, Mortality, Parenting, Meaningful Work, Project Management The following music was used for this episode: Music: Summer Awakening by Frank Schroeter License (CC BY 4.0): https://filmmusic.io/standard-license Music: Tuesday by Sascha Ende License (CC BY 4.0): https://filmmusic.io/standard-license
Are you feeling down or depressed? When you feel down, do you have a tendency to engage in all or nothing thinking? In this episode, Danny and Randy discuss depression and all or nothing thinking.In this episode, we refer to the books “Feeling Good” and “Feeling Great” by David D. Burns, M.D.Subscribe to ESP's YouTube Channel! Thanks for listening! Do you have a question you want answered in a future episode? If so, send your question to: existentialstoic@protonmail.com
Premier League footballer Michail Antonio gets honest about the hidden cost of elite success, identity, and what it really means to rebuild. In this episode, Michail reflects on the reality of winning a historic trophy with West Ham, only to spend months struggling with depression and feeling overwhelmed by the pressure that followed. He also opens up about starting therapy at 34 to unpack childhood experiences, masculinity, and relationships, before discussing the reality of surviving a near-fatal car crash. It's a conversation about how success doesn't shield you from mental health struggles, and how healing often begins when you start to understand what's been driving you underneath the surface.This episode covers the following themes: High-Functioning Depression, Childhood Conditioning, Therapy, Mortality, and Identity.Humans Not Robots by Michail Antonio explores the collision of elite football and real life, revealing the unseen, deeply human side of life as a Premier League player. Out now in hardback, ebook and audiobook (HarperNonFiction) – https://lnk.to/humansnotrobots/amazonbooksAG1
Go follow my new podcast 2 Dudes 1 Scene Podcast with Dan Bollen. And follow my IG @thiswasthescene Small Towns Burn a Little Slower was a Minneapolis/St. Paul band that blended emo, indie rock, and pop punk into a sound that felt both melodic and emotionally raw. Formed in 2002, they quickly built a loyal following through relentless touring and releases on Rise Records, Triple Crown Records, and Dead Letter Records. Their 2005 full length, Mortality as Home Entertainment, earned them recognition from Alternative Press as one of its "100 Bands You Should Know About." Their music paired soaring hooks with introspective lyrics, making them a standout in the mid 2000s emo scene alongside many of the era's rising bands. Although they called it a day in 2008, their catalog has continued to find new listeners and remains a favorite among fans of heartfelt, guitar driven punk and emo. Chitty from Houston Calls mentioned them on his interview so I gave them a listen, dug it, got them on the Zoom, and this is what we chat about: The Minnesota scene The bread theft Getting on Rise Records Their first tour being 3 months long Triple Crown Records Recording with Ed Rose Auditioning for Drive Thru Myspace Kind of getting screwed by Immortal Records And a ton more Ryan has a new EP so go check it out. Give Toilet Rats and We Are The Willows a listen wherever you do the streaming thing.
In a world racing toward smarter machines, empathy speakers and authors Rob Volpe and Maria Ross get curious in this limited subseries about what only humans can feel, do, and be — and why that's our greatest competitive advantage. Enjoy this limited subseries on The Empathy Edge.Mortality, Impermanence & Why It Drives EverythingWe may be the only species that lives with the conscious knowledge of our own death. Maria and Rob sit with an uncomfortable truth of human existence: that we are finite, and that knowledge shapes how we love, create, grieve, and find meaning. Something AI cannot even register.We explore what it means to be a time-malleable species - aware of the past, present, and future in ways no other animal appears to be - and we are most when time starts to run out. We look at evidence of grief in elephants and chimps, asking whether mourning requires mortality awareness or whether it's something else. Rob asks Maria about her own 2008 near-death experience from a brain aneurysm, and together they wrestle with the near-death experience as a pivot point: the moment when abstract knowledge of death becomes real, and life suddenly looks completely different. To access the episode transcript, go to www.TheEmpathyEdge.com and search by episode title."One of the fundamental aspects of the human experience is knowing that death's coming, but we all, as humans, deal with that knowledge very differently." — Rob Volpe Episode References: Rob's project: Cross-generational conversations: form.typeform.com/to/Mf5GDlYTRob's newsletter: Hardwired to be afraid: readingbetweenthelines.beehiiv.com/p/the-only-thing-we-have-to-fear-is-the-story-fear-tells-usThe Empathy Edge:Ashley Jones: How to Courageously Lead and Support Through GriefStephanie Sarazin: What Is Ambiguous Grief and How To Show UpRon Gura: How Technology Helps People Navigate Grief and LossJane Goodall Institute on chimp grief: news.janegoodall.org/2019/07/24/now-we-must-redefine-man-or-accept-chimpanzees-ashumansKara Swisher Wants to Live Forever: cnn.com/kara-swisher-wants-to-live-foreverSan Junipero episode: Black Mirror: en.wikipedia.org/wiki/San_JuniperoRebooting My Brain by Maria RossMy Stroke of Insight by Jill Bolte TaylorThe Tibetan Book of the DeadUpload Washington Post:Perspective piece by a hospice worker: wapo.st/4oPoZGp7 Things to Know about Death, per Death Doulas: wapo.st/4oSLOZUAbout Maria Ross: Maria Ross is a speaker, author, empathy strategist, and host of The Empathy Edge podcast, now in its sixth year. She believes cash flow, creativity, and compassion are not mutually exclusive™, and has spent decades helping leaders balance empathy with accountability to drive better results, stronger teams, and lasting impact. She is the author of four books, including the award-winning The Empathy Dilemma, a Forbes.com contributor on Workplace Empathy, and creator of two LinkedIn Learning empathy courses. About Rob Volpe: Rob Volpe is the Founder/CEO of Empathy Activist and the creator of The 5 Steps to Empathy, which he chronicles in his award-winning book Tell Me More About That: Solving the Empathy Crisis One Conversation at a Time. He is a recognized thought leader, speaker, and consultant in the improvement of communication and collaboration in organizations of all sizes in all industries. Connect with Rob Volpe: Website: robvolpe.expert Book: Tell Me More About That: Solving the Empathy Crisis One ConversationX: x.com/rmvolpe LinkedIn: linkedin.com/in/rmvolpe Facebook: facebook.com/EmpathyActivist Instagram: instagram.com/empathy_activist Connect with Maria:Get Maria's books: Red-Slice.com/booksHire Maria to speak: Red-Slice.com/Speaker-Maria-RossTake the LinkedIn Learning Courses! Leading with Empathy and Balancing Empathy, Accountability, and Results as a Leader LinkedIn: Maria RossInstagram: @redslicemariaFacebook: Red Slice
Reflections on Life and Faith - Update from John Carter - 7-9-26
The Well Seasoned Librarian : A conversation about Food, Food Writing and more.
Well Seasoned Library Podcast:Season 17, Episode 8,Guests: Gail Rosenblum and Kait Ziemer-DavisBook: SEA SALT EATERY: Recipes to Enjoy Year-RoundBio: Located mist-distance from Minnehaha Falls, South Minneapolis fish stand Sea Salt has been a beloved summer gathering spot for more than twenty years. A feast of recipes from panko walleye to grilled catfish, Thai tuna, crabcakes, BBQ shrimp, and more, Sea Salt Eatery: Recipes to Enjoy Year-Round opens the kitchen doors to regulars—and the curious few who haven't been—with stories from employees past and present that capture the fun and flavor of the iconic restaurant.ABOUT THE AUTHORSGail Rosenblum, a retired editor and columnist for the Minnesota Star Tribune, is author of A Hundred Lives Since Then: Essays on Motherhood, Marriage, Mortality, and More.Kait Ziemer-Davis has made her career in restaurants, beginning at Café Teresa in South Dakota and moving on to stints at Chatterbox, Modist, St. Paul's award-winning Joan's in the Park, and, since 2010, Sea Salt Eatery.Sea Salt Restaurant: https://www.seasaltmpls.com/Instagram: @seasalteatery
How can a song change its meaning without changing its words?In the next installment of The Songs That Made Us, Gunter Swoboda explores Hurt through the radically different lives and recordings of Trent Reznor and Johnny Cash.Written by a young man confronting addiction, numbness, and self-destruction, Hurt became something profoundly different eight years later when Cash recorded it near the end of his life. The same words that once expressed an attempt to feel became an inventory of mortality, regret, love, and acceptance.Drawing on psychology, cultural history, Erikson's theory of integrity versus despair, and the emotional function of music, Gunter asks a deeper question: What changes when the life poured into a song changes?This isn't about deciding which version is better. It's about understanding how music can hold different psychological truths—and why some songs seem capable of growing older with us.Key TopicsHow the same song can carry different psychological meaningsTrent Reznor, addiction, numbness, and emotional regulationJohnny Cash, mortality, aging, and life reviewSelf-injury and the psychological experience of numbnessErikson's integrity versus despairMortality salience and the stripping away of symbolic defensesMusic as recognition, regulation, remembrance, and reconciliationThe cultural relationship between confessional country and alternative rockWhy Hurt continues to endureHow listeners re-inhabit songs throughout their own livesHow can a song change its meaning without changing its words?In the next installment of The Songs That Made Us, Gunter Swoboda explores Hurt through the radically different lives and recordings of Trent Reznor and Johnny Cash.Written by a young man confronting addiction, numbness, and self-destruction, Hurt became something profoundly different eight years later when Cash recorded it near the end of his life. The same words that once expressed an attempt to feel became an inventory of mortality, regret, love, and acceptance.Drawing on psychology, cultural history, Erikson's theory of integrity versus despair, and the emotional function of music, Gunter asks a deeper question: What changes when the life poured into a song changes?This isn't about deciding which version is better. It's about understanding how music can hold different psychological truths—and why some songs seem capable of growing older with us.KeywordsHurt, Johnny Cash, Trent Reznor, Nine Inch Nails, Songs That Made Us, psychology of music, regret, mortality, addiction, shame, self-injury, emotional numbness, integrity versus despair, Erik Erikson, aging, dignity, music and memory, cultural psychology, Gunter Swoboda, Inspire ChangeKey TopicsHow the same song can carry different psychological meaningsTrent Reznor, addiction, numbness, and emotional regulationJohnny Cash, mortality, aging, and life reviewSelf-injury and the psychological experience of numbnessErikson's integrity versus despairMortality salience and the stripping away of symbolic defensesMusic as recognition, regulation, remembrance, and reconciliationThe cultural relationship between confessional country and alternative rockWhy Hurt continues to endureHow listeners re-inhabit songs throughout their own livesTakeawaysA song's psychological meaning can change when a different life inhabits it.Reznor's Hurt gives language to numbness, addiction, and damaged connection.Cash's recording transforms the same words into an accounting of mortality, regret, and acceptance.Music can perform different psychological work: recognition, regulation, remembrance, and reconciliation.The songs that endure are often specific enough to feel deeply personal yet open enough for others to find themselves inside them.Sometimes the song doesn't change. We do.Sound Bites“Same words. Same melody. They are not really the same song.”“How does a song change its meaning without changing a single word?”“The song was written by a young man trying to survive his own addiction and finished years later by an old man trying to make peace with his death.”“Sometimes the song doesn't change. We do.”TakeawaysA song's psychological meaning can change when a different life inhabits it.Reznor's Hurt gives language to numbness, addiction, and damaged connection.Cash's recording transforms the same words into an accounting of mortality, regret, and acceptance.Music can perform different psychological work: recognition, regulation, remembrance, and reconciliation.The songs that endure are often specific enough to feel deeply personal yet open enough for others to find themselves inside them.Sometimes the song doesn't change. We do.Reflection QuestionsWhat piece of music has meant something different to you at two distinct points in your life?What changed in you—not the song?If you took an honest inventory of your life today, what would it say?And how might that accounting look twenty years from now?This Week's ReflectionWrite one page addressed to your future self at seventy. Describe what you hope an honest accounting of your life will say.Don't aim for comfort. Aim for accuracy.GratitudeWe want to extend a huge thank you to our listeners in Onaway (on-uh-way) for not only bringing Michigan all the way to #1 on the Top 10 USA listeners list, but your city alone contributed to over 4,000 of our downloads! Thank you for your incredible support! And to our Global Listeners, we extend our gratitude to our listeners in Guatemala City for bringing Guatamala to #19 on our Global listeners list for the first time ever! CONGRATULATIONS!! you made the Top Listeners List.Become a supporter of this podcast: https://www.spreaker.com/podcast/inspire-change-with-gunter--3633478/support.PatreonIf this episode resonates with you and you'd like to go deeper into practical exercises and guided reflection, Gunter offers extended self-development resources and exercises through our Patreon community: www.patreon.com/inspirechangeSponsorDistil UnionThis episode of Inspire Change with Gunter is brought to you by Distil Union, creators of beautifully designed, functional everyday carry accessories that help bring organization, simplicity, and intention into your daily life.Distil Union blends craftsmanship with thoughtful design to help you carry what matters most — without the clutter.
Madonna is 68. Her new music reflects something all of us eventually face: mortality. After decades of projecting strength and invincibility, she's speaking more openly about aging, loss, and what it means to grow older after losing her brother. It raises a question we all spend too much time avoiding: Why do we devote so much of our lives to things that ultimately don't matter? Politics. Social media outrage. Money. Fame. Status. We chase all of it while the one thing none of us can stop is time. One of the world's most famous biohackers spent millions trying to reverse aging—only to develop a serious autoimmune disease. It's a reminder that no amount of money, technology, or science can make us immortal. So if we can't beat death…how should we live? Today's episode explores the only issue every human being shares: how to make the most of the time we have before it's gone. Also on today's show: • Why aren't Democrats demanding more answers about Mitch McConnell's health? • Is it finally time for Graham Platner to step aside? If this episode makes you think, please LIKE, SUBSCRIBE, and SHARE. Your support helps independent voices survive. Support The Karel Cast on Patreon: patreon.com/reallykarel
Why are suicide rates increasing? What about modern life might cause someone to lose hope? In this episode, Danny and Randy discuss why suicide rates are higher now.If you are struggling with suicidal thoughts, please reach out to someone or call the hotline at 988Subscribe to ESP's YouTube Channel! Thanks for listening! Do you have a question you want answered in a future episode? If so, send your question to: existentialstoic@protonmail.com
Ecclesiastes 12 confronts the reality of aging, mortality, and the urgency of turning toward God while there is still time. Solomon uses vivid pictures of the body's decline to remind us that strength, ability, and earthly comforts are temporary. Rather than causing despair, this truth becomes an invitation to repentance, wisdom, and a life centered on God now. Solomon teaches that true wisdom comes through trustworthy instruction, correction, and lived experience. Life is not just something to study but a gift to enjoy through love, gratitude, relationships, and obedience. The final call is simple: fear God, love Him fully, love others deeply, and allow Christ to transform a self-focused life into one marked by generosity, patience, and enduring love.
Grifter-in-Chief, Dan and Elissa's Cultural Corner, Black People Lead The Way, Climb Every Building, Shark Snark, and more!
“You know when you interview someone and you know they're gonna be a star?” Chioma asks Chloe on today's episode of the podcast. For Chioma, that moment came in the winter of 2020 when she first interviewed Anok Yai for the April Global Runway cover. Back then Yai was just at the beginning of her career, and now six years later, in celebration of her June British Vogue cover story, Chioma chatted with her again, this time for the podcast. With couture just around the corner, Yai is working out and journaling but the couture schedule is much more laid back. She's grateful for the more open schedule as well as for the intricate pieces she gets to model. Recalling an Alexander McQueen show which she considers one of the most distinct she tells Chioma that upon looking at the dress she remarked “I can't believe a human being made this.” The British Vogue profile, written by British Vogue's Beauty and Wellness Director Funmi Fetto, explores a recent difficult chapter in Yai's life in which she became seriously ill. Yai becomes emotional, talking to Chioma about that challenging period. “While I was in the hospital, I wasn't really thinking about my career at all. And then there was one day when I was feeling frail. I remember thinking, "Oh, I could pass away right now, and there's nothing I can do about it."” “It took a while for me to find an understanding of why,” she says. But it has also given her a new lease on life and a perspective for how precious and fragile life is, ‘I respect what I was put through.I look at life with whole new eyes.” Recovery was a slow road but she credits her friends and family for supporting her through that period. They also talk about the shoot itself and being on set with two of her closest collaborators, photographer Rafael Pavarotti and hair stylist Jawara, as well as both of her parents—a family affair! Also on today's episode, Chloe and Chioma share about their recent mini vacations to Il Pellicano, Italy and Charleston, South Carolina respectively and look ahead to this weekend which might contain the wedding of the century: Taylor Swift and Travis Kelce at Madison Square Garden. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Theme: Preparing for Life's Storms (personal, relational, spiritual)Hosts introduce the Moral Support Podcast live session and explain it's a conversation between two friends that airs on streaming platforms (Spotify, Apple) — listeners can find episodes there. The central lesson: storms (external crises, personal struggles, grief, loss) are inevitable for everyone, so the question is not “will a storm come?” but “am I built and prepared for the storm?” Practical metaphor: prepare for storms the way you prepare for weather (umbrellas, supplies) and the way lighthouses are built during calm seas so they withstand storms — build stability before crisis hits. Distinction of storm types: external storms (events around you), internal storms (fear, anxiety, intrusive thoughts), spiritual storms, and storms that arise from our own choices/neglect; each can overlap and affect mind, body, emotions, and relationships. Key takeaways: Expect difficulty rather than be surprised by it; anticipatory preparation (stress inoculation) helps you handle hardship better. Preparation includes memorizing Scripture, regular prayer, grounding in truth, and spiritual practices so you can access truth quickly when intrusive or fearful thoughts arise. Mental techniques: observe your thoughts (create cognitive distance), ask “Is this helping me or hurting me?” and replace unhelpful thoughts with truth (word replacement therapy). Specific coping tools and why they workScripture memorization as “storm prep”: having Scripture readily available allows immediate replacement of fearful thoughts, rather than searching for a verse in crisis. Whole Armor metaphor: put on truth, righteousness, the helmet of salvation, shield of faith, sword of the Spirit so you have both defensive and offensive spiritual resources while maintaining feet shod with peace. Cognitive distancing: label a thought (“this is a thought I'm having”), step outside the “jar” so you can see the thought's origin (memory, stress response) and decide whether to water or starve it. Grounding techniques in sensory awareness (notice sounds, chair under you, clock) to re-anchor in the present when overwhelmed; this pulls you out of catastrophic imagining. Gratitude practice (journaling/regular thankful observation) reshapes attention: training your brain to look for positives increases detection of good things and counters the reticular activation system that amplifies negatives. Research and experiential claims were both invoked in the talk. Mental health and therapyHosts affirm therapy (pro-therapy), note prior stigma, and recommend therapy as an available help that doesn't replace spiritual practices — “get a therapist, but don't see a therapist before you see God” summarizes the integration of supports. Holistic view: struggles show up across physical, mental, spiritual, and emotional domains; a problem beginning in one domain commonly bleeds into the others, so fight on multiple fronts. Decision-making in stormsPrinciple: emotions are high and judgment is often low during storms; therefore pre-decide key responses where possible — determine ahead of time how you will act so you don't make irreversible choices in a highly emotional state. The “decision to not decide” is itself a decision; the remedy is preparing choices in advance and practicing responses so you can act wisely when pressured. Recovery and resilience after stormsSurviving can be simple persistence: sometimes resilience is sustained holding on — continued prayer, Scripture, and faith practice rather than dramatic accomplishments. Testimonies referenced holding on through miscarriage and grief by clinging to trust in God. Rebuild stronger: post-storm assessment reveals vulnerabilities; when rebuilding, reinforce the weak points so you don't repeat the same failures (build back stronger and wiser). Practical, actionable steps (daily habits to prepare)Memorize and rehearse Scripture lines that counter fear (examples referenced: “God has not given me the spirit of fear…” and “No weapon formed against me shall prosper”) so you can quote them quickly in crisis. Daily spiritual disciplines: read the Word, pray, put on spiritual “armor” each day so you're habitually prepared rather than reactive. Cognitive practice: when a negative thought appears, ask “Is this helping me or hurting me?” and “Is this true or a lie?” — then either replace it or let it go. Practice pausing and creating distance from the thought. Sensory grounding: name five things you can hear, feel, or see to return to present reality when anxiety spikes. Gratitude journaling: write daily simple thanks (start small) to rewire attention toward positives. Get support: form a “moral support partner,” bring a notebook to church, highlight and personalize scriptures, and consider therapy when needed (therapy + spiritual practice). Warnings and important distinctionsNot every negative moment is demonic or spiritual — some storms are natural, some are consequences of neglect or poor choices, and some are intentionally allowed by God for reasons beyond present understanding; discernment matters. Avoid making life-altering decisions in the heat of crisis; instead rely on pre-made decisions or wait for clarity when possible. Stigma around counseling is decreasing; therapy is framed as a helpful, legitimate avenue of care that complements spiritual practice. Mindset shifts emphasizedYou are not your thoughts; you are the thinker — adopt the posture of gatekeeper, not captive, of your mental life. Mortality awareness (Memento Mori) gives perspective: recognizing life's brevity helps prioritize what truly matters and avoid wasting energy on small battles. Weakness can qualify you for God's strength — vulnerability does not disqualify you from being helped or chosen for endurance. Short checklist to “be built for the storm”Daily: Scripture reading + memorize at least one fighting verse; prayer and putting on spiritual armor. Weekly: practice gratitude journaling; review decisions you may face and pre-decide responses to likely triggers. As needed: use grounding (name senses) during acute anxiety; reach out for a moral-support partner; consider therapy when struggles exceed personal coping. Encouragement and closing convictionsYou are not alone in storms — maintain the posture that Jesus (the speakers' anchor) is “in the boat” and present with you; stay connected to anchors (truth, community, practices) and hold on. Storms refine and form character; surviving them and rebuilding intentionally yields greater strength and wisdom for future storms. Final exhortation from the session: you can make it through your storm — hold on, do what you know to do, prepare in advance, and build back stronger. Follow us on IG at MoralSupportPodcast or our personal social media accounts.https://www.facebook.com/ginger.labathttps://www.facebook.com/sharamckee/
In this conversation, Keltie is joined by Caroline Lee, a death doula and somatic therapist who supports women and couples with the Kids or Childfree choice. You'll hear them discuss: Caroline's personal journey to motherhood, and the career pivot that took her from photographer, to death doula and therapist. How fear, grief, shame, and mortality influence decisions around parenthood. How to work through grief and shame when confronting the Kids or Childfree choice. The role of psychedelics like psilocybin and ibogaine in exploring the decision of whether to have kids. The significance of making conscious, intentional decisions about parenthood. ...and so much more. (1:48) Meet Caroline & her Kids or Childfree decision; (10:27) The work of a death doula; (16:52) Coping with grief and shame in the Kids or Childfree decision; (30:57) Mortality + the Kids or Childfree decision; (45:51) Using psychedelics for decision-making About Caroline: Caroline Lee is a death doula, somatic therapist, writer, and mother of 2. She is the creator of To Babe or Not to Babe, a six-week group for people deciding whether to become parents, remain childfree, or have another child. Her work explores death, desire, grief, the body, and the threshold moments where a life starts asking to be lived more truthfully. Her kids are Moses and Octavia, 2.5 years and 5 months old, and she had them at 37 and 39 years old. She and her partner live in the Bay of San Francisco. As mentioned in the episode: Find Caroline and her 6-week group program, To Babe or Not to Babe, online at www.tobabeornottobabe.com. Find her on social media at @howcarolinecarolines MORE HELP FOR YOUR KIDS OR CHILDFREE DECISION: Start Here: sign up for an upcoming WORKSHOP
The FiltrateJoel Topf kidneyboy.bsky.socialSwapnil Hiremath @hswapnil.medsky.social Pedro Teixeira @nephcrit.bsky.socialSpecial GuestsEwout J. Hoorn, Professor of Medicine Erasmus MC, Netherlands. One of the primary authors.Harish Seethapathy, Assistant physician at Massachusetts General HospitalEditingVipin VergheseThe Kidney Connection written and performed by Timothy YauShow Notes A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients in NEJM Evidence, in PubMed, in NephJCSeethapathy: Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis in NEJM EvidenceMacMillan: Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia in NEJM EvidenceSALSA: Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial in JAMA Internal MedicineSALT 1 and 2: Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia in NEJM Hyponatremia registry: Current treatment practice and outcomes. Report of the hyponatremia registry in Kidney InternationalThe Richard Sterns' article on the lower mortality with more severe hyponatremia: Mortality and Serum Sodium: Do Patients Die from or with Hyponatremia? in CJASNThe European Hyponatremia Guidelines: Clinical practice guideline on diagnosis and treatment of hyponatraemia in The European Journal of EndocrinologyThe American Hyponatremia Guidelines: Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations in American Journal of MedicineTreating hyponatremia: damned if we do and damned if we don't by Tom Berl in Kidney InternationalProspective (clamp) versus reactive (rescue) DDAVP in hyponatremia: Safety and efficacy of proactive versus reactive administration of desmopressin in severe symptomatic hyponatremia: a randomized controlled trial in Nature Scientific Reports and as covered in PBFluidsHelbert Rondon's RCT of urea Urea for Chronic Hyponatremia on ClinicalTrials.govTubular SecretionsSwapnil: Catfishing on CatNet: A Novel by Naomi Kritzer (Amazon)Harish: Disney CruiseEdward: Flesh: A Novel (Booker Prize Winner) by David Szalay (Amazon)Pedro: Scrubs reboot (IMDB)Joel: KIDNEYcon
Alcohol intake and health study: No protective effect at low levels, with mortality increasing to 1 in 25 at 14 Drinks per week Journal of Studies on Alcohol and Drugs This study used a cause-specific modeling approach to estimate the lifetime risk of alcohol-attributable mortality and morbidity in the United States based on a person's average lifetime weekly alcohol consumption to assess the impact of per-occasion alcohol consumption on health. Researchers found that alcohol consumption, including at what may be perceived as “moderate” levels, is associated with increased mortality and morbidity risks. These results support tightening alcohol use guidance in the United States, for both males and females, to no more than 1 drink per day. Read this issue of the ASAM Weekly Subscribe to the ASAM Weekly Visit ASAM
Mortality and the RAGE OF ACHILLES. Guest: Professor Emily Wilson. The conclusion of the Iliad explores the resolution of Achilles' rage following the death of Hector. Initially, Achilles attempts to prolong Hector's humiliation by dragging his body behind a chariot and refusing to allow a proper burial. However, the funeral games for Patroclus mark a shift toward maturity, as Achilles provides a space for competition that does not end in death. He even shows a degree of grace—or perhaps a subtle insult—by awarding Agamemnon a prize without a contest. The poem finishes with a humanitarian pause that allows the Trojans to bury Hector, bookending the story with funerals. The final voices are those of mourning women, emphasizing the shared human experience of grief and the inevitable suffering that follows war. Wilson concludes that the Iliad is fundamentally about the struggle to accept mortality, a theme that has provided comfort and insight to readers for over 2,700 years. 8
Mortality and the End of the Iliad. Guest: Professor Emily Wilson. The final stages of the Iliad focus on Achilles' intense grief and the rituals surrounding death. Following the violent funeral pyre for Patroclus, Achilles organizes funeral games, which Wilson suggests represent his growing realization that all mortals are ultimately "losers" in the face of death. These games provide a new model for competition where skillful men can win prizes without the conflict ending in the destruction of society. A significant moment of reconciliation—or perhaps a "sick burn"—occurs when Achilles gives Agamemnon a prize for spear-throwing without requiring him to compete, acknowledging Agamemnon's status while potentially mocking his habit of taking things he did not earn. The poem notably concludes not with the fall of Troyor the Trojan Horse, but with the voices of three women—Andromache, Hecuba, and Helen—singing laments. Their grief highlights the future of enslavement and loss facing the survivors. This ending, marked by a humanitarian pause for Hector's funeral, underscores the poem's central theme: the universal struggle to accept human mortality. 1
Send us Fan MailIn this retrospective single-center study from Toronto, Adrianne and Nim explore the echo findings of preterm infants with septic shock and hypoxemic respiratory failure. Contrary to the common assumption that elevated pulmonary vascular resistance drives hypoxemia in sepsis, the data points to left ventricular dysfunction as a key contributor. Babies with hypoxemic respiratory failure showed lower LV systolic and diastolic performance, while pulmonary pressures were similar between groups. Mortality was significantly higher in the hypoxemic group. This challenges the reflex to reach for nitric oxide first and asks clinicians to look at the whole heart.----Cardiopulmonary Physiology of Hypoxemic Respiratory Failure Among Preterm Infants with Septic Shock. Kharrat A, Nissimov S, Zhu F, Deshpande P, Jain A.J Pediatr. 2025 Mar;278:114384. doi: 10.1016/j.jpeds.2024.114384. Epub 2024 Nov 6.PMID: 39510164Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
Multiple myeloma is the second most common blood cancer in the United States and has long been considered a difficult disease to treat. For decades, treatment options were limited, and survival remained poor. However, the therapeutic landscape has changed dramatically over the past several decades with the introduction of stem cell transplantation, targeted drugs, immunotherapies, and more recently, CAR T-cell therapy and bispecific antibodies. A research paper titled “Targeted therapeutics and U.S. population-level mortality trends in multiple myeloma: A SEER-based analysis from 1975 to 2023” was published in Volume 17 of Oncotarget. In this study, the researchers examined how these major treatment advances have coincided with changes in multiple myeloma mortality across the United States over nearly five decades. The study was led by first and corresponding author Navkirat Kahlon from the Mass General Cancer Center at Wentworth-Douglass Hospital in Dover, New Hampshire. Full blog - https://www.oncotarget.org/2026/06/29/targeted-therapies-have-coincided-with-a-dramatic-decline-in-multiple-myeloma-mortality-in-the-united-states/ Paper DOI - https://doi.org/10.18632/oncotarget.28877 Correspondence to - Navkirat Kahlon - nkahlon@mgb.org; (ORCID: https://orcid.org/0000-0003-1115-2029) Abstract video - https://www.youtube.com/watch?v=-TNWkG9FyUo Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28877 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, multiple myeloma, epidemiologic trends, mortality reduction, therapeutic advancements, SEER database To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
"What if the biggest challenge in life isn't how much time you have—but how wisely you use it? In Psalm 90, Moses invites us to see our lives through the lens of God's eternity. Our days are brief, our plans are fragile, and our accomplishments are temporary. Yet instead of leading us to despair, this perspective calls us to a deeper trust in the God who has been our dwelling place through every generation. This message explores what it means to number our days, pursue true wisdom, and find lasting hope in the One who remains faithful when everything else fades. Whether you're wrestling with the pace of life, facing uncertainty about the future, or simply longing for an eternal perspective, Psalm 90 offers both clarity and comfort. Discover how God's unchanging character gives purpose to our fleeting lives, why humility is the beginning of wisdom, and how His grace transforms ordinary days into opportunities for eternal significance. If this message encourages you, be sure to like, subscribe, and share it with someone who needs the reminder that life is short—but God's faithfulness is forever."
Join Kortney and Dr. Payel Gupta as they unpack chronic spontaneous urticaria. Together, they define what hives actually are, explain how CSU is different from an allergic reaction and other types of hives, and walk through what is happening under your skin to cause all that itching. This episode was originally published June 6, 2024. We re-released it on June 25, 2026 with a new intro as the perfect foundation before our episode on the new chronic urticaria guidelines. Do you get hives and have no idea why? Then this episode is for you. What we cover in this episode about chronic hives: What hives really are. Urticaria is the medical word for hives, and the two signs are that it itches and it comes and goes. CSU versus other hives. How CSU differs from inducible hives (CINDU) and from an allergic reaction. Histamine and the itch. Why histamine drives the swelling and itch, and why scratching feels so good. What makes hives flare. CSU has no true trigger, but stress and other culprits can set off your mast cells. The Itch Podcast Hives Episodes Explore our full catalog of hives episodes Diagnosis and the basics Ep. 76 Diagnosing Chronic Spontaneous Urticaria Ep. 128 Is Chronic Spontaneous Urticaria an Autoimmune Disease? Ep. 90 Challenges in Diagnosis and Treatment of Chronic Urticaria in Skin of Color Treatment Ep. 78 Chronic Spontaneous Urticaria Treatments Ep. 131 What Is a BTK Inhibitor? Ep. 147 The REMIX Trial: Remibrutinib for Chronic Hives Ep. 116 Why Fexofenadine Is Considered a Truly Non-Sedating Antihistamine Living with chronic hives Ep. 148 How Do You Know Your Chronic Hives Are Under Control? Ep. 122 Mortality in adult patients with chronic spontaneous urticaria: A real-world cohort study Ep. 80 Chronic Spontaneous Urticaria Myths and Misconceptions Ep. 79 Living with Chronic Spontaneous Urticaria: A patient story Ep. 91 A Patient's Experience with Chronic Urticaria and Skin of Color Ep. 107 Hives in the Latinx Community ______ This podcast is made in partnership with Allergy and Asthma Network. We thank Novartis for originally sponsoring this episode. This podcast is for informational purposes only and does not substitute professional medical advice. Any mention of brands is also informational and not an endorsement. Always consult with your healthcare provider for any medical questions or concerns.
Reposted here is my interview on Anna Fata Shemin's wonderful podcast, the Gravitas Podcast. Sign up, follow her incredibly thoughtful work: https://open.spotify.com/episode/432S3SNi56e0njlHgjAa1B?si=nT910BvxRO6Y267cdG-IuA---"Old money" is more than a TikTok aesthetic trend. There are real lessons to learn from the families who cultivate generational wealth, and they go far beyond the money.This week I sit down with Bogumil Baranowski, a Polish-born investor who came to New York to live the American dream and has spent two decades managing wealth for families. He's the author of four books, a TEDx speaker, and the host of the podcasts Talking Billions and co-host of 100 Year Thinkers.We talk about his childhood in communist Poland and how it influenced his career as an investor and Warren Buffett devotee. We discuss stewardship and how lasting family wealth has less to do with trust funds and more to do with family culture. He also discusses how money is not a prerequisite for living a truly rich life.Links from this episode:
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So now we know where Prince Harry and Meghan are staying on their trip to the UK next week and it’s… emotional. Also, is Pauline Hanson Australia’s Trump, and did her muddy message on Paid Parental Leave make the answer clearer? Support independent women’s media and get our biggest offer of the year. Subscribe here for 30% off your annual Mamamia subscription. Code applied at the checkout. Offer ends June 30. There’s a tech-bro who says Australia aged him 13 years and honestly, same. Plus, why Madonna’s life is just too expensive for a bio-pic. And, some MAFS stars have travelled to Bali for a cosmetic procedure that could possibly be replaced by… buying a belt. What To Listen To Next: Listen to our latest episode: Two Bachelorettes, Zero Chill: Taylor’s Mystery Party Listen: A Very Cranky William & A Very Wicked Woman Listen: 'I Can’t Cook' Is The New 'I Don’t Want Kids' Listen: ‘My Hardest Night As A Mum’: Jessie's 3-Month Check-In Listen: So The Wedding Has Happened & Kyle Sandilands' Big D*ck Deal Listen: The Ariana Grande Panic Listen: Um, WTF Is Going On With Gwyneth & A Very Beckham Weekend Connect your subscription to Apple Podcasts Check out the Mamamia Out Loud newsletter. Discover more Mamamia Podcasts here including the very latest episode of Parenting Out Loud, the parenting podcast for people who don't listen to... parenting podcasts. SUBSCRIBE here: Support independent women's media You can now watch our show in full length video on the Apple Podcast app - make sure your phone is up to date and we can't wait for you to see Mamamia Out Loud on Apple What to read: Prince Harry said he misses the UK but can't take his children there. Buckingham Palace responded. The part of Pauline Hanson's speech everyone's talking about. MAFS stars are flying to Bali to have their ribs 'remodelled.' We have questions. Do this today to live longer. THE END BITS: Check out our merch at MamamiaOutLoud.com GET IN TOUCH: Feedback? We’re listening. Send us an email at outloud@mamamia.com.au Share your story, feedback, or dilemma! Send us a voice message. Join our Facebook group Mamamia Outlouders to talk about the show. Follow us on Instagram @mamamiaoutloud and on Tiktok @mamamiaoutloud Mamamia acknowledges the Traditional Owners of the Land on which we have recorded this podcast.Become a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.
In part two of this two-part series, Mike and Ryan discuss why families often abandon medication too quickly after a single difficult trial, the importance of trial-and-error in finding the right medication regimen, and why genetic testing isn't the shortcut many parents hope it will be.Find Mike @ www.grownowadhd.comFind Ryan @ www.adhddude.comTimestamps[00:00:00] Start[00:00:46] Why Families Give Up on Medication Too Easily[00:01:30] Two Main Stimulant Categories Explained[00:03:42] Non-Stimulant Medication Options[00:04:22] Why Medication Alone Is Not Enough[00:07:15] Genetic Testing Is Not Recommended[00:09:43] Key Takeaways on ADHD Medication[00:12:13] Final Thoughts on Kids and Medical DecisionsCitationsAmerican Academy of Child and Adolescent Psychiatry. (2020). Clinical use of pharmacogenetic tests in prescribing psychotropic medications for children and adolescents. https://www.aacap.org/aacap/Policy_Statements/2020/Clinical-Use-Pharmacogenetic-Tests-Prescribing-Psychotropic-Medications-for-Children-Adolescents.aspxAmerican Academy of Child and Adolescent Psychiatry. (2022). Attention-deficit/hyperactivity disorder: Parents' medication guide. https://www.aacap.org/App_Themes/AACAP/docs/resource_centers/resources/med_guides/ADHD_Medication_Guide-web.pdfAmerican Psychiatric Association. (n.d.). What is ADHD? https://www.psychiatry.org/patients-families/adhd/what-is-adhdCenters for Disease Control and Prevention. (2024). Clinical care of ADHD. https://www.cdc.gov/adhd/hcp/treatment-recommendations/index.htmlDalsgaard, S., Leckman, J. F., Mortensen, P. B., Nielsen, H. S., & Simonsen, M. (2015). Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: A prospective cohort study. The Lancet Psychiatry, 2(8), 702–709. https://doi.org/10.1016/S2215-0366(15)00271-0Dalsgaard, S., Østergaard, S. D., Leckman, J. F., Mortensen, P. B., & Pedersen, M. G. (2015). Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: A nationwide cohort study. The Lancet, 385(9983), 2190–2196. https://doi.org/10.1016/S0140-6736(14)61684-6de Vries, W., Boer, M., Stevens, G. W. J. M., & van Dorsselaer, S. (2025). Exploring concept creep: Youth's portrayal of ADHD on TikTok. SSM Mental Health, 7, 100374.Harpin, V., Mazzone, L., Raynaud, J. P., Kahle, J., & Hodgkins, P. (2016). Long-term outcomes of ADHD: A systematic review of self-esteem and social function. Journal of Attention Disorders, 20(4), 295–305. https://doi.org/10.1177/1087054713486516Myer, N. M., Boland, J. R., & Faraone, S. V. (2018). Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD. Molecular Psychiatry, 23, 1929–1936.Shaw, M., Hodgkins, P., Caci, H., Young, S., Kahle, J., Woods, A. G., & Arnold, L. E. (2012). A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: Effects of treatment and non-treatment. BMC Medicine, 10, 99. https://doi.org/10.1186/1741-7015-10-99Wetterer, L. (2020). Attention-deficit/hyperactivity disorder: AAP updates guideline for diagnosis and management. American Family Physician, 102(1), 58–60.Wolraich, M. L., Hagan, J. F., Allan, C., Chan, E., Davison, D., Earls, M., Evans, S. W., Flinn, S. K., Froehlich, T., Frost, J., Holbrook, J. R., Lehmann, C. U., Lessin, H. R., Okechukwu, K., Pierce, K. L., Winner, J. D., & Zurhellen, W. (2019). Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics, 144(4), e20192528. https://doi.org/10.1542/peds.2019-2528Yeung, A., Ng, E., & Abi-Jaoude, E. (2022). TikTok and attention-deficit/hyperactivity disorder: A cross-sectional study of social media content quality. The Canadian Journal of Psychiatry, 67(12), 899–906. https://doi.org/10.1177/07067437221082854
The brutal part of juggling isn't the hard trick. It's the simple demand that never changes: once the object leaves your hand, you either catch it or you don't. From a snowy, sleety Malmö cabaret week at Victoria Theater, we sit down in a hotel room surrounded by ribbons, feathers, and confetti while Jay Gilligan rolls his legendary Ivar Balls, and we ask the mid-career question that every performer eventually faces: does life actually get easier, or do you just get better at carrying it? We get practical about performance pressure, stage presence, and why technical mastery doesn't erase the feeling of risk. Jay talks about building a professional “floor” where a truly bad show becomes rare, not because you're perfect, but because you've earned tools, timing, and recovery instincts. We also dig into the creative process of making new work, where everything feels equally important at first, then slowly reveals a hierarchy as you perform it again and again. If you self-produce, you'll recognize the trap: props, music, lighting, marketing, and logistics all scream for attention until the piece finally tells you what it's really about. Then we widen the lens to the touring life and the human cost: being away from family, sitting alone in hotel rooms, aging into different limits, and the pandemic's wake-up call that “I can always fall back on street shows” might be a comforting story more than a plan. Underneath it all is a bigger question about meaning, identity, and what work gives us besides money, especially when the end starts to feel closer than the beginning. If this conversation hits home, subscribe, share it with a friend who makes things for a living, and leave a review with the part that stayed with you.Support the show...After a long abscence our Merch Shop is back! Check out t-shirts, hoddies, and hats! Show yourself as a Follower of the Way of the Showman.You can also "listen" to the Way of the Showman at youtube.If you want to help support this podcast it would be tremendous if you wrote a glowing review on iTunes or Spotify.If you want to contact me about anyhthing ou can reach me on thewayoftheshowman@gmail.comYou can find out more on the Way of the Showman website.Follow the Way of the Showman on Instagram.If you're compelled to suport the showes and have the means to do so, you can suport the podcast financially at: https://www.buymeacoffee.com/captainfrodo
Privateers and the Deadly Reality of British Prison Ships. Guest: Professor Richard Bell. Privateers were government-sanctioned pirates who caused significant economic damage to the British while the Continental Navystruggled. William Russell, a schoolteacher, joined a privateering vessel but was captured and imprisoned in the HMS Jersey, a floating "black hole" in Brooklyn Bay. Mortality rates on these ships reached fifty percent, making them the deadliest sites of the entire war. Despite the risks, over 50,000 Americans served on privateering missions, illustrating the global commercial impact of the Revolution and the high human cost for those captured by British forces. 21803 OHIO
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-490 Overview: In the US, maternal morbidity and mortality rates are among the highest in the western world, and stroke is one of the leading causes—responsible for 1 of 12 maternal deaths. This rate is estimated to be much higher in high-risk pregnancies. Join us as we discuss a recent study examining rates of maternal stroke in which 1 in 4 women with stroke experienced a missed diagnostic opportunity and hear what these findings mean for your practice. Episode resource links: Haghighi N, Bourscheid RM, Shang C, et al. Identifying missed diagnostic opportunities in maternal stroke. Stroke. 2026;57(2). doi:10.1161/STROKEAHA.125.052995 Chen Y, Shiels MS, Uribe-Leitz T, et al. 2025. Pregnancy-Related Deaths in the US, 2018-2022. JAMA Network Open. Lappen JR, Pettker CM, Louis JM. 2021. American Journal of Obstetrics and Gynecology. Society for Maternal-Fetal Medicine Consult Series #54: Assessing the Risk of Maternal morbidity and Mortality. American Journal of Obstetrics and Gynecology. Miller EC, Bello NA, Chen PR, et al 2026. Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement from the American Heart Association. Stroke. Bushnell C, Kernan WN, Sharrief AZ, et al. 2024. Guideline for the Primary Prevention of Stroke: A Guideline from the American Heart Association/¬American Stroke Association. Stroke. Guest: Susan Feeney, DNP, FNP-BC, NP-C Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-490 Overview: In the US, maternal morbidity and mortality rates are among the highest in the western world, and stroke is one of the leading causes—responsible for 1 of 12 maternal deaths. This rate is estimated to be much higher in high-risk pregnancies. Join us as we discuss a recent study examining rates of maternal stroke in which 1 in 4 women with stroke experienced a missed diagnostic opportunity and hear what these findings mean for your practice. Episode resource links: Haghighi N, Bourscheid RM, Shang C, et al. Identifying missed diagnostic opportunities in maternal stroke. Stroke. 2026;57(2). doi:10.1161/STROKEAHA.125.052995 Chen Y, Shiels MS, Uribe-Leitz T, et al. 2025. Pregnancy-Related Deaths in the US, 2018-2022. JAMA Network Open. Lappen JR, Pettker CM, Louis JM. 2021. American Journal of Obstetrics and Gynecology. Society for Maternal-Fetal Medicine Consult Series #54: Assessing the Risk of Maternal morbidity and Mortality. American Journal of Obstetrics and Gynecology. Miller EC, Bello NA, Chen PR, et al 2026. Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement from the American Heart Association. Stroke. Bushnell C, Kernan WN, Sharrief AZ, et al. 2024. Guideline for the Primary Prevention of Stroke: A Guideline from the American Heart Association/¬American Stroke Association. Stroke. Guest: Susan Feeney, DNP, FNP-BC, NP-C Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
Solomon teaches that while life is often unpredictable and unfair, we are not called to sit still in fear but to live wisely and faithfully. He encourages generous giving, consistent habits, calculated risks, and trusting God with outcomes we cannot control, knowing that faithful choices often bear fruit over time. He also warns against letting anger, bitterness, and vexation take root, comparing them to a poison that slowly shapes the heart. Instead, believers are called to cultivate joy, gratitude, spiritual disciplines, and a heavenly perspective, choosing daily to bless others, reject resentment, and walk in wisdom despite life's uncertainties.
Today we have another Pulm PEEPs Pearls episode about a core critical care topic. Furf and Monty will be giving a high level overview of the use of steroids in sepsis including a review of the relevant literature and recent guidelines, and pragmatic bedside points. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points Why Steroids in Sepsis? Steroids do not treat the infection — antimicrobials are always first and remain the cornerstone. The goal is addressing critical illness–related corticosteroid insufficiency (CIRCI), where cortisol production cannot keep up with the overwhelming inflammatory demand of septic shock. Hydrocortisone helps in two main ways: Blunts the dysregulated inflammatory response — tempers the excessive vasodilation and febrile response that drive harm beyond the infection itself. Restores vascular sensitivity to catecholamines — sepsis downregulates adrenergic receptors; steroids turn that responsiveness back on. Clinical takeaway: The first thing you notice is vasopressor weaning (or a bend in the escalation curve) — not a rapid improvement in fever or white count. Caveat: These trials predate modern sepsis phenotyping. None distinguish hyperinflammatory vs. hypoinflammatory responders — they treat all comers. The Evidence: Four Landmark Trials Every IM resident and critical care fellow will eventually journal-club these four. The most consistent signal across all of them is faster shock reversal and reduced vasopressor use; the mortality question remains unsettled. Trial (Year)NRegimenKey FindingAnnane (2002)~300Hydrocortisone + fludrocortisoneMortality benefit in ACTH non-responders; criticized methodology and messy cortisol-response testing; not cleanly replicated.CORTICUS (2008)~500Hydrocortisone aloneFaster shock reversal but no mortality benefit, regardless of cortisol responsiveness. Raised (later allayed) superinfection concern. Cornerstone for abandoning routine cort-stim testing.ADRENAL (2018)~3,800Hydrocortisone aloneFaster vasopressor weaning; no 90-day mortality benefit.APROCCHSS (2018)~1,200Hydrocortisone + fludrocortisoneMortality benefit at 90 days. Bottom line: Faster shock reversal is consistent. Mortality benefit appears in 2 of 4 trials (both used fludrocortisone) but not the others. A 2026 meta-analysis showed benefit for hydrocortisone + fludrocortisone vs. placebo, but not for hydrocortisone + fludrocortisone vs. hydrocortisone alone — suggesting hydrocortisone drives the main effect. Who Gets Steroids, and When? 2021 Surviving Sepsis: Consider steroids for norepinephrine or epinephrine ≥ 0.25 mcg/kg/min for ≥ 4 hours despite adequate resuscitation — a reasonable bedside trigger. Early 2026 update: Moved away from a specific numeric trigger — consider steroids when a septic patient is not responding well to vasopressors or has escalating requirements. Make a clinical decision. (Quality of evidence: low to moderate.) Go faster than the threshold when: Known/suspected adrenal insufficiency or home steroids, or florid pressor-requiring shock on arrival. A practical escalation sequence: escalating norepinephrine → add vasopressin (per VASST) → then add steroids if requirements keep climbing. Do NOT wait for an ACTH stimulation test. It does not reliably predict who responds and only delays treatment. Sepsis is an elevated-cortisol state but can dissociate ACTH and cortisol, and cortisol-binding globulin is depleted — the test is too messy to guide care. What to Give: The Regimen Standard dose: Hydrocortisone 200 mg/day, typically 50 mg IV Q6H. (Original trials often used continuous infusions, rarely used in the U.S.) Some start with a 100 mg bolus to gain control. Higher dose: If chronically on steroids / adrenally insufficient, consider ~300 mg/day (e.g., 100 mg Q8H). Fludrocortisone: Unsettled. The two mortality-benefit trials added it (50 mcg PO/NG/OG daily), but hydrocortisone already has mineralocorticoid activity and meta-analyses don't show added benefit over hydrocortisone alone. Most clinicians omit it — adding it is reasonable and safe, just be honest about the uncertainty. Duration & Tapering Typical course: ~7 days is most common. Trial practices varied (ADRENAL ~7 days; VANISH used a taper after 6 days; some continue until pressors are off). No taper needed. You do not need to taper for adrenal insufficiency after a short course — just stop. If pressors dramatically rebound, you can restart, but most patients have gained the benefit they'll get by day 7. Pitfalls & Safety Hyperglycemia: Expected and must be managed (monitor closely; insulin drip if needed). No signal for major DKA / severe complications in the trials. Superinfection / fungal infection: The most-quoted concern, but the overall literature does not show a convincing, statistically significant increase. Be disciplined about stopping on schedule. Muscle weakness: Steroids can worsen critical illness myopathy; a short 7-day course likely has limited effect, but be aware. Other: GI bleeding (follow general PPI prophylaxis guidance) and sodium disturbances (watch for hyper-/hyponatremia). Two things we know: (1) steroids shorten duration of vasopressor support, and (2) they are relatively safe in sepsis. Whether they improve mortality — and in whom — remains open. The Five Pulm PEEPs Pearls Mechanism: Steroids restore catecholamine vascular sensitivity and blunt dysregulated inflammation. The clinical target is vasopressor weaning, not infection treatment. Evidence: Faster shock reversal is the most consistent finding. Mortality benefit is seen in 2 of 4 trials but not the others — still controversial. Some patients likely benefit; we don't yet know who. Trigger: A practical 2021 threshold is levo/epi ≥ 0.25 mcg/kg/min for ≥ 4 hours. Newer guidance drops the strict number — make a clinical decision based on poor pressor response or escalation. Dose: Hydrocortisone 200 mg/day (e.g., 50 mg Q6H). Adding fludrocortisone mirrors two trials, but meta-analyses find no benefit over hydrocortisone alone. Safety: Steroids appear safe in sepsis. Monitor and treat hyperglycemia; no marked increase in superinfection. References and Further Reading Annane, Djillali et al. “Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock.” JAMA vol. 288,7 (2002): 862-71. doi:10.1001/jama.288.7.862 Sprung, Charles L et al. “Hydrocortisone therapy for patients with septic shock.” The New England journal of medicine vol. 358,2 (2008): 111-24. doi:10.1056/NEJMoa071366 Venkatesh, Balasubramanian et al. “Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 797-808. doi:10.1056/NEJMoa1705835 Annane, Djillali et al. “Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 809-818. doi:10.1056/NEJMoa1705716 Sun, Alin et al. “Correction: Hydrocortisone combined with fludrocortisone for treatment of adults with septic shock: an updated meta-analysis and systematic review.” Frontiers in medicine vol. 13 1811616. 2 Mar. 2026, doi:10.3389/fmed.2026.1811616 Prescott, Hallie C et al. “Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.” Critical care medicine vol. 54,4 (2026): 715-724. doi:10.1097/CCM.0000000000007089
What happens when a physicist experiences a moment of transcendence that science cannot explain?Alan Lightman has spent much of his life exploring the mysteries of the universe—from black holes and the nature of time to the fundamental laws that govern reality. A physicist, novelist and longtime professor at MIT, he's fascinated by the transformative power of awe and wonder.In this live conversation recorded at New York's Morgan Library, Lightman reflects on extraordinary encounters in nature—from a startling moment with two ospreys to a solitary night beneath the stars—that shook him to the core and left him feeling as though he had somehow "fallen into infinity." Calling himself a "spiritual materialist," he seeks to bridge the divide between science and religion, between mathematics and art.Can a scientific worldview make room for awe, transcendence, and mystical experience? Lightman says these fleeting moments reveal something essential about being human: our longing to connect with something larger than ourselves.This event at the Morgan Library was co-sponsored by the Nour Foundation as part of our series “Spirituality in the Age of Science: Conversations on God, Transcendence and Mortality.”— Video of Steve's complete conversation with Alan Lightman at Morgan Library: MIT website Books PBS series: "Searching: Our Quest For Meaning in the Age of Science" —0:00 Introduction2:40 The Osprey Encounter9:40 Science And Religion13:30 Scientist And Novelist28:50 The Religious Impulse36:50 Evolution And Consciousness Wonder Cabinet is hosted by Anne Strainchamps and Steve Paulson. Find out more about the show at https://wondercabinetproductions.com, where you can subscribe to the podcast and our newsletter.
In this inspiring episode of The Greatness Machine, host Darius Mirshahzadeh sits down with legendary author Steven Pressfield to discuss his newest novel "The Arcadian" and dive deep into the creative process. Pressfield, author of over 20 books including "The War of Art," "The Legend of Bagger Vance," and "Gates of Fire," shares his journey from a 30-year struggle to published success at age 52. The conversation explores the spiritual and practical aspects of creativity, the concept of resistance, and the warrior mindset needed for artistic achievement. In this episode, Darius and Steven will discuss: (00:00) Introduction to Steven Pressfield (01:05) Steven's Origin Story and Journey to Writing (04:02) Reflections on Past Struggles and Regrets (06:57) The Creative Process and the Role of the Muse (10:02) Uncovering Ideas: The Artist's Journey (12:08) The Impact of 'The War of Art' and Resistance (15:01) Understanding Self-Sabotage and Resistance (18:00) The Spirituality of Creativity vs. Blue Collar Work (21:06) The Importance of Grit and Hard Work (23:54) Expectations vs. Reality in Creative Work (27:05) The Process of Writing and Overcoming Perfectionism (29:54) The Long View: Building a Body of Work (33:02) Channeling Creativity and Letting Go of Outcomes (34:21) The Power of Surrender and Channeling Creativity (37:34) Warrior vs. Mother: The Duality of Creative Virtues (41:58) The Arcadian: A Journey Through Time and Identity (46:31) Striving for Agency: The Artist's Quest (49:41) Making the Unconscious Conscious: The Role of Art (53:10) Reincarnation and Relationships: A Storytelling Device (55:05) Mortality and Legacy: Reflections on the Creative Journey (57:50) AI and Authenticity: The Future of Creativity (59:26) The Grind: Overcoming Barriers to Greatness Steven Pressfield is the bestselling author of The War of Art, with over a million copies sold worldwide. His historical novel Gates of Fire is required reading at West Point and on the recommended reading list of the Joint Chiefs of Staff. The author of more than 18 books, Pressfield lives and writes in California. Connect with Steven: Website: https://stevenpressfield.com/ Instagram: https://www.instagram.com/steven_pressfield/ Facebook: https://www.facebook.com/StevePressfield/ Connect with Darius: Website: https://therealdarius.com/ Linkedin: https://www.linkedin.com/in/dariusmirshahzadeh/ Instagram: https://www.instagram.com/imthedarius/ YouTube: https://www.youtube.com/@Thegreatnessmachine Book: The Core Value Equation https://www.amazon.com/Core-Value-Equation-Framework-Limitless/dp/1544506708 Write a review for The Greatness Machine using this link: https://ratethispodcast.com/spreadinggreatness. Learn more about your ad choices. Visit megaphone.fm/adchoices
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