Podcasts about Mortality

Existential Therapy: Morality, Mortality & Disney's Latest Miss Life. Death. Morality. And… Disney? Yeah, We're Going There. Sometimes you just Continue readingThe Leal Legacy | Existential Therapy The post The Leal Legacy | Existential Therapy first appeared on Leal Legacy.

BUFFALO, NY — July 28, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on June 13, 2025, titled “Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA).” In this study, led by Eric T. Klopack from the University of Southern California, researchers created a new RNA-based aging measure that predicts health risks and mortality. This measure, called Transcriptomic Mortality-risk Age (TraMA), uses gene expression data to estimate a person's biological aging. This finding offers a new and potentially more accurate way to track aging and understand health risks, especially for older adults. Aging is a complex biological process that affects multiple systems in the body and increases the risk of disease and death. Scientists have long looked for reliable ways to measure biological aging. While DNA methylation and blood biomarkers are commonly used, this study focused on RNA—a molecule that reflects gene activity. By analyzing RNA sequencing data from nearly 4,000 U.S. adults aged 50 and older, the team developed TraMA to predict the probability of dying within four years. TraMA proved to be a strong and independent predictor of early death, multiple chronic diseases, poor cognitive function, and difficulties with daily activities. It was also tested in another large group of long-lived families and in several smaller datasets from patients with conditions like diabetes, sepsis, and cancer. The results confirmed the tool's usefulness across different populations and health conditions. “TraMA was also externally validated in the Long Life Family Study and several publicly available datasets.” Unlike earlier RNA-based aging measures, which were often built using small or non-representative samples, TraMA was developed using modern RNA sequencing technology results and a nationally representative dataset. This increases its reliability and potential for broad public health applications. The tool also demonstrated unique advantages over popular biological aging measures like GrimAge and PhenoAge, capturing distinct aspects of aging and health decline. Importantly, TraMA tracks biological processes related to inflammation, immune function, and kidney and brain health, systems that play key roles in aging. It was also sensitive to behavioral and socioeconomic factors. For instance, smoking, obesity, and low physical activity were associated with older TraMA scores. TraMA was also sensitive to changes in biological aging. In one study, researchers measured TraMA at two different time points and found that the more recent scores were better at predicting who would die. This suggests that TraMA can track changes in a person's aging as their health evolves. It also performed well in both large-scale surveys and small clinical samples, making it a useful tool in many types of research. By offering a new, accurate, and flexible method for measuring biological aging, TraMA may help researchers better understand how genes, lifestyle, and environment influence aging. This tool opens the door to more precise research on improving health and extending lifespan. DOI - https://doi.org/10.18632/aging.206272 Corresponding author - Eric T. Klopack - klopack@usc.edu Video short - https://www.youtube.com/watch?v=Tl0CApUz8cU Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

We are much more powerful than we often imagine, and in surprising ways. For most of us, our power is not in being remembered long beyond our lifetimes, or in being able to change the world that is far from us. It is rather in that we are each made by one another, and we make one another, by how we live, what we say, how we listen, and how we act. When we start to see that we are literally making a world for others to live in right here and now, in our every way of conducting ourselves it can open great possibilities both for gratitude and wonder, and great responsibilities for us as parents, friends, colleagues and neighbours in our everyday lives. In this conversation we remember Joanna Macy, whose writing we have featured a number of times, who died on July 19. And we talk together about what it is to be ‘good soil' for one another, so that we get to make a world together that we want to live in.This week's conversation is hosted, as always, by Lizzie Winn and Justin Wise of Thirdspace. Episode Overview 00:00 Introduction and Context Setting 02:59 Nature as a Narrative for Human Life 05:59 Reflections on Mortality and Legacy 08:50 The Interconnectedness of Human Experience 11:54 Being Soil for One Another 14:49 Relationships and Community 18:07 Parenting and World Making 21:06 Cultural Narratives that Limit and Bring to Life 23:49 Conclusion Here's our source for this week: In Honor of Joanna Macy, 1929-2025 I write while staying in one of the great forests of British Columbia, a forest in which the inextricability of life from death is gorgeously evident… Magnificent fallen trees turn back into soil as younger trees reach downward to twine around their ancestors' trunks and upward toward the sky. The roots growing around and gripping these decaying logs look like veins and tentacles and fingers clutching and reaching toward an anchor in the soil. Some of the mature cedars and conifers stand on mounds that must be fully decayed trees or rather once were trees and are further along in the process of becoming soil. Often a great tree that's fallen over still has at its base a tall shield that is its roots still clinging to rounded stones and soil, and from this the trunk stretches across the earth. These trees from which trees grow are known as nurse logs… When I was younger, I was taught what an artist or writer was supposed to aspire to was immortality, the kind that Dante and Li Po and Shakespeare have, so that in centuries to come memory of your name and attention to your creations continue. Later in life, I realized that there was an entirely different thing to aspire to, an entirely different kind of creative success: to be so much part of your own time, of the present that is making the future, that rather than remaining what people think about, you become in some way how people think, how they value, what they prioritize. You stop being what's in front of their eyes and become part of what is behind their eyes, how they see the world, how they live, act, what they aspire to, what they hold close, what they resist. You become a nurse log on which new life can grow as you compost into the soil we call culture. And maybe this is the mindset of moist places, of an ecology of vivid decay and regeneration rather than of the arid places, where death dessicates and the mummies, skeletons, ruins, Dead Sea Scrolls, last for centuries or millennia. Rebecca Solnit, writing in memory of Joanna Macy 1929-2025 From ‘Meditations in an Emergency', Rebecca's ongoing public writing for these times Photo by Tomas Martinez on Unsplash ---- Join Us Live in 2025 Turning Towards Life Live Season 1, from September 2025 We also have the launch of our Turning Towards Life live programme which is going to run in six month seasons from September. It's going to be in person on Zoom once a month. We're very excited about it. A chance to expand beyond the bounds of a podcast into forming a community of learning and practice. You can register your interest for Season 1 of Turning Towards Life Live here. ---- About Turning Towards Life Turning Towards Life, a week-by-week conversation inviting us deeply into our lives, is a live 30 minute conversation hosted by Justin Wise and Lizzie Winn of Thirdspace.  Find us on FaceBook to watch live and join in the lively conversation on this episode. You can find videos of every episode, and more about the project on the Turning Towards Life website, and you can also watch and listen on Instagram, YouTube, and as a podcast on Apple, Google, Amazon Music and Spotify. Join Our Weekly Mailing: www.turningtowards.life/subscribe Support Us: www.buymeacoffee.com/turningtowardslifeKeywords nurse logs, creative success, soil culture, interpenetrating lives, mortality meaning, forest metaphor, humility humus, world making, parenting soil, cultural foundation, death regeneration, collective memory, individual legacy, spiritual ecology, creative immortality, ancestral roots, living decay, fertile ground, cultural inheritance, generational impact, everyday power, relationship making, invisible influence, natural cycles, human connection

Crisis and Compassion: Meredith Parfet on Transforming Loss into Meaning In this episode, we delve deep into the multifaceted world of grief, crisis management, and emotional resilience with Meredith Parfet, a CEO, hospice chaplain and death doula.   Meredith shares her poignant and personal journey with grief, having lost her sister during the early stages of the opioid epidemic, followed by a series of other profound losses.   As CEO of Raynard Group, 'Meredith works with individuals and organizations experiencing Capital C crisis – legal or regulatory action, fatalities, white collar crime, scandal, complex family office disputes. Crisis is not a bad tweet; it changes the trajectory of your life.'   She transitioned from a career in finance to also working with the dying, becoming a death doula and eventually a chaplain, bringing a unique perspective to both grief and crisis management.    Throughout this conversation, Meredith discusses grief, the impact of grief in professional settings, and how executive leaders can manage crises with compassion and presence.   Meredith also emphasizes the significance of turning towards suffering, finding meaning in grief, and the power of 'the next right thing' in navigating life's most challenging moments.   This episode is a rich tapestry of personal story, expert insights, and practical wisdom on handling grief and crises with grace and resilience.     00:00 Introduction and Welcome   00:32 Meredith's Personal Journey with Grief   02:20 Becoming a Death Doula and Hospice Chaplain   03:42 The Intersection of Finance and Mortality   04:14 Understanding Grief Beyond Death   05:24 The Profound Experience of Death and Dying   07:05 Buddhist Philosophy and the Concept of Bardo   10:07 Crisis Management and Professional Grief   20:56 Healthy vs. Unhealthy Grief   25:24 The Transformative Power of Grief   26:28 Finding Meaning in Trauma   27:40 The Role of Outrage in Grief   30:09 Prioritizing During Crisis   32:58 The Healing Power of Service   35:51 Humanizing Leadership   39:40 Balancing Spirituality and Escapism   43:55 Turning Towards Suffering   46:03 The Next Right Thing  

Andrea Gibson, a beloved poet and artist, recently passed away. We are honored to share this special encore episode of their conversation with Tami Simon that originally aired in 2023. Great poets expand our view—of ourselves, of each other, and of the entire universe. Andrea Gibson was named Colorado's 2023–25 Poet Laureate for their celebrated verses on love, LGBTQ issues, spirituality, mental health, social justice, and more. Tami Simon speaks with Andrea about their approach to work and how their journey through cancer radically changed that approach. This poignant conversation featuring Andrea's reading of their poem, “Acceptance Speech After Setting the World Record in Goosebumps” and exploring spiritual surrender, finding joy in every instant, facing challenges, moving through grief, the life force of the universe within us, self-love and loving the whole world, trying softer (not harder), the power of relaxation, identifying the keys that open your heart, staying with our fear, activism and loosening our attachment to desired outcomes, being yourself fully, the gift of mortality, giving the present moment the cold shoulder, why authenticity is the most important thing when it comes to writing, the pull of creativity, and more.

Mortality rates, mental health conditions, obesity and chronic disease rates are all up significantly in American children. Why are kids in the U.S. so unhealthy?

This rich, gorgeous conversation will fill your soul. The singular and beloved Joanna Macy died at home at the age of 96 on July 20, 2025. She has left an immense legacy of beauty and wisdom and courage to sustain us. A Buddhist teacher, ecological philosopher, and Rilke translator, she taught and embodied a wild love for the world. What follows is the second and final conversation Krista had with Joanna, together with Joanna's friend, psychologist and fellow Rilke translator Anita Barrows, in 2021. Joanna and Anita had just published a new translation of Rilke's Letters to a Young Poet. At the turn of the last tumultuous century, Rilke was prescient in realizing that the world as he'd known it was passing away. Joanna's adventurous life and vision took shape in the crucibles of the history that then unfolded. Relistening to her now is to experience a way of standing before the great, unfolding dramas of our time — ecological, political, intimate. We stand before the possibilities of what Joanna called “A Great Unraveling” or “A Great Turning” towards life-generating human society. All of this and so much more comes through in the riches of this life-giving conversation. Sign yourself and others up for The Pause to be on our mailing list for all things On Being and to receive Krista's monthly Saturday morning newsletter, including a heads-up on new episodes, special offerings, recommendations, and event invitations.Joanna Macy was the root teacher of The Work That Reconnects. Her books include Active Hope and four volumes of translated works of Rainer Maria Rilke, together with Anita Barrows: Rilke's Book of Hours: Love Poems to God;  In Praise of Mortality; and A Year with Rilke. Krista's previous "On Being” episode with her is “A Wild Love for the World.” That's also the title of a lovely book of homage to Joanna that was published in 2020. Anita Barrows's most recent poetry collection is Testimony. She is the Institute Professor of Psychology at the Wright Institute in Berkeley, California, and also maintains a private practice. 

In this raw and vulnerable solo episode of The Q-Chat, host Shronda Armstrong invites listeners into a deeply personal space of reflection following the unexpected passing of Malcolm-Jamal Warner. With heavy hearts and open minds, we explore the impact of sudden loss—not just of a beloved figure many of us grew up with, but of time, opportunity, and the unspoken words we often leave behind.Shronda shares candid thoughts on mortality, grief, and how celebrity deaths can stir something profound within us. This conversation journeys through the importance of mending relationships, letting go of resentment, and choosing to live each day with intention. From her own challenges with forgiveness to the urgency of honoring our loved ones while they're still here, this episode is an emotional reminder of how fragile life truly is.As you listen, you'll be encouraged to reevaluate your connections, cherish your time, walk in your purpose, and find joy in the present moment—even on the hard days. Because in the end, death reminds us of one simple truth: we must live while we're still here.Timestamps:00:00 – Reflections on Mortality and Celebrity Deaths11:31 – The Impact of Death on Personal Relationships21:14 – Living with Purpose and Gratitude31:32 – Embracing Life and Overcoming Fear41:55 – Closing Message: Live, Love, and Geaux Love Ya'selfConnect with Shronda at ⁠⁠www.geauxqueen.com⁠⁠ for podcast episodes, magazine features, Pink Reign calls, and in-person empowerment events in Dallas. And remember: Geaux reclaim your power. Geaux walk in your truth. And most importantly—Geaux love ya'self.

Watch the best scene reading: https://www.youtube.com/watch?v=DLrcCUBi10A Facing death due to different illnesses, three patients find themselves playing a made up game called The Mortality Game to experience life one last time risking it all. www.instagram.com/thevelamonster Get to know the writer: What is your screenplay about? It's about 116 pages! Sorry, I just had to get one “Dad Joke” in, even though I'm NOT a Dad (that I know of). “The Mortality Game' is in essence a story of life as seen through the lens of impending death. It's about how we as humans face the “final act” of the stage play of our lives. In the case of my three headed lead: Schubert, Halada and Tugger face it in their own differing, yet quirky ways. Ultimately deciding to take a final road trip across the country while playing a game where they do dangerous things to challenge and defy death, since they have nothing to lose. What genres does your screenplay fall under? Character Driven Dramedy for the most part, as it has elements of Comedy and Drama, with a bit of Coming of Age mixed in for good measure. Why should this screenplay be made into a movie? Because the characters are as diverse in age and attitude as they are strong in development and memorability. Because the story, about how we face death is an important one to tell, since that is a situation that none of us can avoid. Because it explores letting go as well as fighting back, finding the joy in the dreaded, and allowing yourself to feel what you feel facing the end, whether it's understandable or not, expected or not, appropriate or not. Subscribe to the podcast: https://twitter.com/wildsoundpod https://www.instagram.com/wildsoundpod/ https://www.facebook.com/wildsoundp

The incidence of early onset colorectal cancer (EOCRC) has been rising prompting the change in change in screening guidelines to 45 years of age for average risk patients. Join us for an in-depth discussion with guest speakers Dr. Andrea Cercek and Dr. Nancy You, where we provide a comprehensive look at the growing challenge of EOCRC. Hosts: - Dr. Janet Alvarez - General Surgery Resident at New York Medical College/Metropolitan Hospital Center - Dr. Wini Zambare – General Surgery Resident at Weill Cornell Medical Center/New York Presbyterian - Dr. Phil Bauer, Graduating Colorectal Surgical Oncology Fellow at Memorial Sloan Kettering Cancer Center  - Dr. J. Joshua Smith MD, PhD, Chair, Department of Colon and Rectal Surgery at MD Anderson Cancer Center - Dr. Andrea Cercek - Gastrointestinal Medical Oncologist at Memorial Sloan Kettering Cancer Center - Dr. Y. Nancy You, MD MHSc - Professor, Department of Colon and Rectal Surgery at MD Anderson Cancer Center Learning objectives:  - Describe trends in incidence of colorectal cancer, with emphasis on the rise of EOCRC. - Identify age groups and demographics most affected by EOCRC. - Summarize USPSTF recommendations for colorectal cancer screening. - Distinguish between screening methods (e.g., colonoscopy, FIT-DNA) and their sensitivity. - Understand treatment approaches for colon and rectal cancer (CRC) - Understand the role of mismatch repair (MMR) status in guiding treatment. - Outline the importance of genetic counseling and testing in young patients. - Discuss racial, ethnic, and socioeconomic disparities in CRC incidence and outcomes. - Describe the impact of cancer treatment on fertility and sexual health. -  Review fertility preservation options. - Identify the value of integrated care teams for young CRC patients. References: 1.         Siegel, R. L. et al. Colorectal Cancer Incidence Patterns in the United States, 1974–2013. JNCI J. Natl. Cancer Inst. 109, djw322 (2017). https://pubmed.ncbi.nlm.nih.gov/28376186/ 2.         Abboud, Y. et al. Rising Incidence and Mortality of Early-Onset Colorectal Cancer in Young Cohorts Associated with Delayed Diagnosis. Cancers 17, 1500 (2025). https://pubmed.ncbi.nlm.nih.gov/40361427/ 3.         Phang, R. et al. Is the Incidence of Early-Onset Adenocarcinomas in Aotearoa New Zealand Increasing? Asia Pac. J. Clin. Oncol.https://pubmed.ncbi.nlm.nih.gov/40384533/ 4.         Vitaloni, M. et al. Clinical challenges and patient experiences in early-onset colorectal cancer: insights from seven European countries. BMC Gastroenterol. 25, 378 (2025). https://pubmed.ncbi.nlm.nih.gov/40375142/ 5.         Siegel, R. L. et al. Global patterns and trends in colorectal cancer incidence in young adults. (2019) doi:10.1136/gutjnl-2019-319511. https://pubmed.ncbi.nlm.nih.gov/31488504/ 6.         Cercek, A. et al. A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. J. Natl. Cancer Inst. 113, 1683–1692 (2021). https://pubmed.ncbi.nlm.nih.gov/34405229/ 7.         Zheng, X. et al. Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer. JNCI J. Natl. Cancer Inst. 113, 543–552 (2021). https://pubmed.ncbi.nlm.nih.gov/33136160/ 8.         Standl, E. & Schnell, O. Increased Risk of Cancer—An Integral Component of the Cardio–Renal–Metabolic Disease Cluster and Its Management. Cells 14, 564 (2025). https://pubmed.ncbi.nlm.nih.gov/40277890/ 9.         Muller, C., Ihionkhan, E., Stoffel, E. M. & Kupfer, S. S. Disparities in Early-Onset Colorectal Cancer. Cells 10, 1018 (2021). https://pubmed.ncbi.nlm.nih.gov/33925893/ 10.       US Preventive Services Task Force. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA 325, 1965–1977 (2021). https://pubmed.ncbi.nlm.nih.gov/34003218/ 11.       Fwelo, P. et al. Differential Colorectal Cancer Mortality Across Racial and Ethnic Groups: Impact of Socioeconomic Status, Clinicopathology, and Treatment-Related Factors. Cancer Med. 14, e70612 (2025). https://pubmed.ncbi.nlm.nih.gov/40040375/ 12.       Lansdorp-Vogelaar, I. et al. Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates. Cancer Epidemiol. Biomarkers Prev. 21, 728–736 (2012). https://pubmed.ncbi.nlm.nih.gov/22514249/ 13.       Ko, T. M. et al. Low neighborhood socioeconomic status is associated with poor outcomes in young adults with colorectal cancer. Surgery 176, 626–632 (2024). https://pubmed.ncbi.nlm.nih.gov/38972769/ 14.       Siegel, R. L., Wagle, N. S., Cercek, A., Smith, R. A. & Jemal, A. Colorectal cancer statistics, 2023. CA. Cancer J. Clin. 73, 233–254 (2023). https://pubmed.ncbi.nlm.nih.gov/36856579/ 15.       Jain, S., Maque, J., Galoosian, A., Osuna-Garcia, A. & May, F. P. Optimal Strategies for Colorectal Cancer Screening. Curr. Treat. Options Oncol. 23, 474–493 (2022). https://pubmed.ncbi.nlm.nih.gov/35316477/ 16.       Zauber, A. G. The Impact of Screening on Colorectal Cancer Mortality and Incidence: Has It Really Made a Difference? Dig. Dis. Sci. 60, 681–691 (2015). https://pubmed.ncbi.nlm.nih.gov/25740556/ 17.       Edwards, B. K. et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544–573 (2010). https://pubmed.ncbi.nlm.nih.gov/19998273/ 18.       Cercek, A. et al. Nonoperative Management of Mismatch Repair–Deficient Tumors. New England Journal of Medicine 392, 2297–2308 (2025). https://pubmed.ncbi.nlm.nih.gov/40293177/ 19.       Monge, C., Waldrup, B., Carranza, F. G. & Velazquez-Villarreal, E. Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations. Cancers 17, 1325 (2025). https://pubmed.ncbi.nlm.nih.gov/40282501/ 20.       Monge, C., Waldrup, B., Carranza, F. G. & Velazquez-Villarreal, E. Ethnicity-Specific Molecular Alterations in MAPK and JAK/STAT Pathways in Early-Onset Colorectal Cancer. Cancers 17, 1093 (2025). https://pubmed.ncbi.nlm.nih.gov/40227607/ 21.       Benson, A. B. et al. Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Compr. Cancer Netw. JNCCN 19, 329–359 (2021). https://pubmed.ncbi.nlm.nih.gov/33724754/ 22.       Christenson, E. S. et al. Nivolumab and Relatlimab for the treatment of patients with unresectable or metastatic mismatch repair proficient colorectal cancer. https://pubmed.ncbi.nlm.nih.gov/40388545/ 23.       Dasari, A. et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. The Lancet 402, 41–53 (2023). https://pubmed.ncbi.nlm.nih.gov/37331369/ 24.       Strickler, J. H. et al. Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study. Lancet Oncol. 24, 496–508 (2023). https://pubmed.ncbi.nlm.nih.gov/37142372/ 25.       Sauer, R. et al. Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer. N. Engl. J. Med. 351, 1731–1740 (2004). https://pubmed.ncbi.nlm.nih.gov/15496622/ 26.       Cercek, A. et al. Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer. JAMA Oncol. 4, e180071 (2018). https://pubmed.ncbi.nlm.nih.gov/29566109/ 27.       Garcia-Aguilar, J. et al. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. J. Clin. Oncol. 40, 2546–2556 (2022). https://pubmed.ncbi.nlm.nih.gov/35483010/ 28.       Schrag, D. et al. Preoperative Treatment of Locally Advanced Rectal Cancer. N. Engl. J. Med. 389, 322–334 (2023). https://pubmed.ncbi.nlm.nih.gov/37272534/ 29.       Kunkler, I. H., Williams, L. J., Jack, W. J. L., Cameron, D. A. & Dixon, J. M. Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer. N. Engl. J. Med. 388, 585–594 (2023). https://pubmed.ncbi.nlm.nih.gov/36791159/ 30.       Jacobsen, R. L., Macpherson, C. F., Pflugeisen, B. M. & Johnson, R. H. Care Experience, by Site of Care, for Adolescents and Young Adults With Cancer. JCO Oncol. Pract. (2021) doi:10.1200/OP.20.00840. https://pubmed.ncbi.nlm.nih.gov/33566700/ 31.       Ruddy, K. J. et al. Prospective Study of Fertility Concerns and Preservation Strategies in Young Women With Breast Cancer. J. Clin. Oncol. (2014) doi:10.1200/JCO.2013.52.8877. https://pubmed.ncbi.nlm.nih.gov/24567428/ 32.       Su, H. I. et al. Fertility Preservation in People With Cancer: ASCO Guideline Update. J. Clin. Oncol. 43, 1488–1515 (2025). https://pubmed.ncbi.nlm.nih.gov/40106739/ 33.       Smith, K. L., Gracia, C., Sokalska, A. & Moore, H. Advances in Fertility Preservation for Young Women With Cancer. Am. Soc. Clin. Oncol. Educ. Book 27–37 (2018) doi:10.1200/EDBK_208301. https://pubmed.ncbi.nlm.nih.gov/30231357/ 34.       Blumenfeld, Z. How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries. The Oncologist 12, 1044–1054 (2007). 35.       Bhagavath, B. The current and future state of surgery in reproductive endocrinology. Curr. Opin. Obstet. Gynecol. 34, 164 (2022). 36.       Ribeiro, R. et al. Uterine transposition: technique and a case report. Fertil. Steril. 108, 320-324.e1 (2017). 37.       Yazdani, A., Sweterlitsch, K. M., Kim, H., Flyckt, R. L. & Christianson, M. S. Surgical Innovations to Protect Fertility from Oncologic Pelvic Radiation Therapy: Ovarian Transposition and Uterine Fixation. J. Clin. Med. 13, 5577 (2024). 38.       Holowatyj, A. N., Eng, C. & Lewis, M. A. Incorporating Reproductive Health in the Clinical Management of Early-Onset Colorectal Cancer. JCO Oncol. Pract. 18, 169–172 (2022). ***Behind the Knife Colorectal Surgery Oral Board Audio Review: https://app.behindtheknife.org/course-details/colorectal-surgery-oral-board-audio-review Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

Show notes at pharmacyjoe.com/episode1045. In this episode, I'll discuss possible design flaws in a recent study that suggested cefepime has a mortality benefit over piperacillin-tazobactam. The post 1045: Think Cefepime Has a Mortality Benefit Over Pip-Taz? Not So Fast Say These Authors... appeared first on Pharmacy Joe.

In this conversation, Tony Siebers, a real estate agent and founder of Parent Projects, discusses the intersection of real estate and the challenges faced by aging populations. He shares insights on the importance of understanding morbidity and mortality, the role of family caregivers, and how AI can assist in navigating the complexities of aging. The conversation also touches on ethical considerations in real estate and caregiving, as well as the catalysts that drive change in the aging process. Professional Real Estate Investors - How we can help you: Investor Fuel Mastermind:  Learn more about the Investor Fuel Mastermind, including 100% deal financing, massive discounts from vendors and sponsors you're already using, our world class community of over 150 members, and SO much more here: http://www.investorfuel.com/apply   Investor Machine Marketing Partnership:  Are you looking for consistent, high quality lead generation? Investor Machine is America's #1 lead generation service professional investors. Investor Machine provides true ‘white glove' support to help you build the perfect marketing plan, then we'll execute it for you…talking and working together on an ongoing basis to help you hit YOUR goals! Learn more here: http://www.investormachine.com   Coaching with Mike Hambright:  Interested in 1 on 1 coaching with Mike Hambright? Mike coaches entrepreneurs looking to level up, build coaching or service based businesses (Mike runs multiple 7 and 8 figure a year businesses), building a coaching program and more. Learn more here: https://investorfuel.com/coachingwithmike   Attend a Vacation/Mastermind Retreat with Mike Hambright: Interested in joining a “mini-mastermind” with Mike and his private clients on an upcoming “Retreat”, either at locations like Cabo San Lucas, Napa, Park City ski trip, Yellowstone, or even at Mike's East Texas “Big H Ranch”? Learn more here: http://www.investorfuel.com/retreat   Property Insurance: Join the largest and most investor friendly property insurance provider in 2 minutes. Free to join, and insure all your flips and rentals within minutes! There is NO easier insurance provider on the planet (turn insurance on or off in 1 minute without talking to anyone!), and there's no 15-30% agent mark up through this platform!  Register here: https://myinvestorinsurance.com/   New Real Estate Investors - How we can work together: Investor Fuel Club (Coaching and Deal Partner Community): Looking to kickstart your real estate investing career? Join our one of a kind Coaching Community, Investor Fuel Club, where you'll get trained by some of the best real estate investors in America, and partner with them on deals! You don't need $ for deals…we'll partner with you and hold your hand along the way! Learn More here: http://www.investorfuel.com/club   —--------------------

Welcome back to The Superhumanize Podcast. I am so deeply honored to have you with me today for a conversation that is close to the very core of what it means to be human.My guest is Dr. Hsien Seow, Canada Research Chair in Palliative Care and Health System Innovation, Professor at McMaster University, and one of the foremost voices reimagining how we approach serious illness and end-of-life care. His work transcends the medical system, inviting us to see palliative care not as surrender, but as a path to reclaiming agency, dignity, and meaning, even, and perhaps especially, in life's most vulnerable chapters.Dr. Seow's book, Hope for the Best, Plan for the Rest, co-authored with Dr. Samantha Winemaker, is a guide to navigating life-changing diagnoses with clarity, courage, and grace. It offers seven keys to transform the illness journey from one of fear and disempowerment to one of hope and preparedness.In today's conversation, we explore the paradigm shifts needed in healthcare, the deeper truths mortality can teach us about life, and how we can each become active architects of our own experience, even when the path ahead feels out of our control.This episode is about much more than palliative care. It is about what it means to live fully awake to our finite nature, and to love, decide, and be present with the preciousness of this human life.Episode Highlights:02:30 – Realizing a disconnect: the moment Hsien noticed future doctors weren't trained to talk about dying, sparking his mission to change the system.04:00 – What palliative care really means: an approach that centers on the full human experience—emotional, spiritual, social—not just medical intervention.06:30 – Why timing matters: most people meet palliative care too late. Hsien and his colleague Dr. Sammy Winemaker push for earlier integration.07:15 – The key concept: “Hope for the best, plan for the rest” — balancing optimism with informed planning.08:30 – Reclaiming power from the medical system: how patients and families can move from passive to activated roles.10:00 – “Zooming out” to see the big picture: why asking what stage you're in is essential to living fully.12:15 – How to move from silence to agency: the role of courageous conversations in healing.14:45 – The ripple effect: illness doesn't just affect the patient—it shapes families and communities.16:30 – Family dynamics and understanding: how knowing someone's coping style reduces conflict and increases compassion.20:00 – What to do when the patient avoids discussion: using gentle invitations instead of confrontations.25:00 – Real-life application: how Hsien's own family used these principles to navigate care with love and tact.27:30 – Cultural myths and medical systems: how we've lost the communal experience of dying and what needs to change.30:15 – Reframing grief and loss: learning from everyday changes how to prepare for bigger transitions.32:30 – Dying as sacred: honoring diversity in spiritual beliefs and values through customized care.34:45 – The invisible load: recognizing and supporting family caregivers before burnout sets in.38:30 – Revisiting roles and expectations: how adaptability sustains families through long-term illness.40:00 – Everyday palliative care: acts of love like cooking, walking a pet, or simply being present.42:00 – Customize your order: bringing your whole self—values, beliefs, and personality—into your care.44:30 – One key question: “What do I need to know about you to give you the best...

MORTALITY. After a jarring family event flips his world upside down, Chris confronts some of life's biggest questions: What does it mean to live knowing our time is finite? How do we find purpose in the face of our own impermanence? And can confronting death actually teach us to live more fully? Joined by 3Q3D regulars Amanda Adams and Matt Jordan, this conversation about life's ultimate deadline proves delightfully refreshing – just like the 3 cocktails shared by the group.DRINKS IN THIS EPISODE: Chambord Old Fashioned >> 2 oz Bulleit rye whiskey, ¼ oz Chambord, ¼ oz simple syrup, 2 dashes Angostura bitters. Stir ingredients in a mixing glass with ice and serve over one large ice cube. Garnish with a Luxardo cherry and drink like your heart condition is 100% genetic. Mint Watermelon Fizz cocktail >> 4 oz watermelon juice (blend several cups of watermelon chunks in a blender and strain out any pulp); 1 oz Vodka, ½ oz mint simple syrup. Combine ingredients in a cocktail shaker with ice and pour into a rocks glass with crushed ice and top with a splash of soda water. Garnish with a mint sprig and freshly cut slice of watermelon. Congratulations, by eating fruit you just made a heart healthy decision!Southside Cocktail >> 5 muddled mint leaves, I oz lemon juice, 2 oz gin, ½ oz simple syrup. Muddle mint leaves with lemon, add gin and simple syrup, shake on ice and strain into a cocktail glass. Serve with mint sprig and enjoy one of summer's most refreshing cocktails while pondering your own mortality.If you've been enjoying the 3Q3D podcast, please subscribe and consider giving us a rating, a review, or sharing an episode with a friend.  Follow our social sites here: Instagram:  https://www.instagram.com/3drinkspodcast/?hl=en  Facebook:  https://www.facebook.com/3Drinkspodcast  

New Study Alert!

In this episode of the Saving Lives Podcast, we review a July 2025 study from the Journal of Intensive Care comparing methylprednisolone and hydrocortisone for severe pneumonia treatment. The discussion focuses on how these findings may influence clinical decisions, particularly for patients with septic shock. The Vasopressor & Inotrope HandbookAmazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/47qJZe1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Affiliate Link)My Store: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://eddyjoemd.myshopify.com/products/the-vasopressor-inotrope-handbook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Use "podcast" to save 10%)Sato T, Sasabuchi Y, Inokuchi R, Aso S, Yasunaga H, Doi K. Mortality of severe pneumonia treated with methylprednisolone versus hydrocortisone: a propensity-matched analysis. J Intensive Care. 2025 Jul 15;13(1):39. doi: 10.1186/s40560-025-00810-1. PMID: 40665428; PMCID: PMC12261853.

Pastor Dru Rodriguez candidly explores the heartache that comes with watching loved ones grow older and face loss, urging us not to shy away from our pain but to lean into God's promise of comfort. He highlights that, even when grief feels paralyzing, Scripture assures us that God is near to the brokenhearted.

 Living a "To-Die-For" Life with Karen SalmansohnEpisode Description:Are you living a full life—or just going through the motions? In this powerful and thought-provoking episode of Linda's Corner, bestselling author and behavioral change expert Karen Salmansohn shares how to break free from “near-life experiences” and start living with more joy, purpose, and intention—before it's too late.With over 2 million books and courses sold, Karen is known for blending humor, science-backed insights, and practical tools to help people create real transformation. She's been featured on Oprah.com, CNN, The Today Show, Psychology Today, USA Today, and more. Today, she reveals how embracing “death awareness” can spark the motivation to pursue your passions, deepen your relationships, and stop procrastinating on the life you truly want.What You'll Learn in This Episode:Why so many people feel stuck in “near-life experiences”How the awareness of mortality can actually increase happiness and motivationThe difference between pleasure and true happiness (thanks, Aristotle!)How to live by your core values and shape your identity through daily choicesWhy writing your own eulogy can be a powerful life-planning toolThe secret to building habits that align with the person you want to becomeThe surprising power of identity-based affirmations: “I am loving. I am discerning.”How to tell whether an activity is a “soul feeder” or a “time waster”Karen's message is clear: “Mortality awareness creates urgency. Urgency creates action.” Don't wait until “someday” to pursue your dreams—start now.If you're ready to stop drifting and start living with more clarity, joy, and intention, this episode is a must-listen.

A CrimeCast Podcast Share! Roddy and Clint are back in the studio and they covered a lot of ground! Tech - Gear - Big Brother - Training Mortality - MORE! Policing & the Community - Cold/Active Cases - Safety Tips - Famous/Infamous Cases - Special Guests AND all Wrapped in Entertainment and Stories! Share us with your friends - leave us reviews - help us spread the word! - Hosted by Clint Powell and David Roddy Powered by: https://www.kubotaofchattanooga.com/ Sponsored by: 1st Lead U Podcast - www.1stleadu.com Big Woody's Tree Service: https://bigwoodystreeservice.com/ ALL THINGS JEFF STYLES: www.thejeffstyles.com PART OF THE NOOGA PODCAST NETWORK: www.noogapodcasts.com Please consider leaving us a review on Apple and giving us a share to your friends! This podcast is powered by ZenCast.fm

On Episode 54 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2025 issue of Stroke: “Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality” and “Effect of Argatroban Plus Dual Antiplatelet in Branch Atherosclerosis Disease: A Randomized Clinical Trial.” She also interviews Dr. Amrou Sarraj about the article “Mechanical Thrombectomy for Large Ischemic Stroke: A Critical Appraisal of Evidence From 6 Randomized Controlled Trials.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250710.454589

What can founders learn from elite athletes, and how does coachability translate into venture building? In this episode of The Augmented Life, Michael Tiffany sits down with Ruben A. Austin, founder of All In All, former football player, and serial entrepreneur. From growing up in Düsseldorf to joining an NFL international recruitment program, Ruben's journey spans continents, careers, and communities. They dig deep into Ruben's philosophy on adaptability, leadership, and why building real human connection offline, is still the most powerful force in business. Ruben also shares what it takes to curate a high-trust room, how he sees seasonality shaping creative work, and why slowing down is the ultimate founder superpower.—⏱️ Timestamps00:00 – Intro: From athlete to entrepreneur01:13 – Growing up in Düsseldorf & playing American football02:13 – NFL pipeline & facing failure early03:31 – Why Ruben chose Mystique as his favorite villain04:27 – Coachability and adaptability in startups06:24 – What makes someone truly coachable07:23 – Why peer groups may matter more than mentors08:14 – Surrounding yourself with people who tackle big problems09:38 – Trump, thinking big, and perspective shifts11:05 – Worst-case scenario thinking as a mental unlock12:19 – Mortality as a driver for intentional living14:32 – Can AI replicate the soul of human creativity?16:13 – Empathy, texture, and what AI still can't do17:24 – What “good energy” really means at events19:00 – From transactions to relationships: Ruben's evolution20:25 – Shared interests as the root of strong communities22:20 – Why New York's seasonality drives creativity24:28 – Slowing down to spark ideas25:46 – Summer, seasonality, and the hidden opportunity in downtime27:14 – Optimizing during off-seasons28:20 – Fundraising, VC cycles, and the post-Labor Day relaunch28:55 – Where to find Ruben and All In All—

Our heroes investigate the mysteries of Sigil as they continue to move their walking castle towards RibcageCome join us on Discord:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://discord.gg/ntaEjvc⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us on Patreon!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/IndoorAdventures⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Merch:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠indooradventure.red⁠⁠⁠bubble.com

What exactly makes us feel disgusted? Is disgust for a person or group ever justified? And is disgust useful, or should we try to eliminate it?Chapters:[00:00] Introduction to Disgust and Cognitive Content[00:11] Paul Rosen's Experiments on Disgust[02:16] Disgust and Its Connection to Animality and Mortality[03:05] Projective Disgust and Social Implications[05:06] Disgust in Legal Theory and Practice[08:00] Personal Anecdotes on Disgust and Social Change[11:18] Disgust Towards Transphobia and Body Malleability[13:24] Disgust in Art and Pornography[22:17] Disgust, Fear, and Contamination[23:13] Overcoming Disgust and Social Progress[29:49] Caste and Disgust in India and America[31:45] Tagore's Critique of Caste and Disgust[35:02] Progress and Challenges in LGBTQ+ Rights[43:07] The Role of Disgust in Political and Social Issues[52:45] Age Discrimination and Societal AttitudesCheck out FeedSpot's list of 90 best philosophy podcasts, where Brain in a Vat is ranked at 15, here: https://podcast.feedspot.com/philosophy_podcasts/

Show notes at pharmacyjoe.com/episode1042. In this episode, I'll discuss early vs delayed norepinephrine use in patients with septic shock. The post 1042: Early Norepinephrine Use in Septic Shock is Associated with Reduced Mortality appeared first on Pharmacy Joe.

In this deeply reflective episode of Podsongs, musical duo Samana (www.samanaroad.com) — Rebecca Rose Harris and Franklin Mockett — engage in a soulful and thought-provoking dialogue with award-winning poet and novelist Anne Michaels, author of Fugitive Pieces (www.annemichaels.ca).Topics Covered: The role of solitude in the creative processArt as ritual, healing, and transcendenceThe subconscious mind and dreams as creative catalystsReflections on death, absence, and presenceLife in rural France, Italy, and WalesThe impact of technology on creativityIndigenous wisdom, shamanism, and the unseenThe power of analog recording and emotional truth in musicCreating a new piece of music inspired by the conversationThis episode was recorded during Samana's artistic residency in the French countryside, and culminates in a musical collaboration inspired by Anne Michaels and the themes of the conversation.Whether you're an artist, writer, musician, or seeker, this interview will resonate with the part of you drawn to beauty, mystery, and meaning.Stream the song: https://ffm.to/thresholds00:00 Introduction to Samana00:36 Journey Through Eastern Europe00:59 Creating in Solitude01:24 Philosophy Behind Samana's Music01:54 Life in the Welsh Countryside02:19 Anne Michaels Joins the Conversation03:01 Reflections on Life in France and Italy03:14 The Artistic Residency and Creative Process11:32 COVID-19 and Artistic Collaboration13:18 Exploring Anne Michaels' Work18:01 Shamanic Performance and Symbolism19:34 Creative Inspiration and Interconnection21:39 Connecting Deeply with Anne Michaels38:48 Rituals in Writing and Life41:54 Analog Sound and Emotional Truth43:23 Nature and the Subconscious46:58 The Dead, Thresholds, and Memory48:47 Indigenous Wisdom and Seeing the Unseen01:02:57 Death, Dreams, and the Subconscious01:12:19 Rituals as Creative Anchors01:30:56 Solitude vs. Digital Distraction01:44:04 Mortality and Personal Transformation01:48:55 The Role of Absence in Creation01:56:42 Death, Mystery, and the Poetic Lens02:00:27 Artistic Collaboration and Intimacy02:16:28 Gratitude and the Journey02:25:00 Closing Reflections and Future Work// SUPPORT THIS CHANNEL //Newsletter, donations and download the song for €/$1 @ https://podsongs.com// LINKS //Website: https://podsongs.comPodcast episodes: https://podsongs.com/podcast-episodesSongs: https://podsongs.com/musicSpotify artist: https://open.spotify.com/artist/32FYyRx1y1ex3jHHAgLMC7?si=4Nv7WW85SbSPZvCsj1o7IgSpotify playlist: https://open.spotify.com/playlist/6sN1viy82HPiNTVX2YBxpq?si=1b84c2b9bdea4656// SOCIAL //Twitter: https://twitter.com/podsongsInstagram: https://instagram.com/podsongsFacebook: https://facebook.com/podsongs

In this special episode of the Daughter Podcast, Oscar reflects on a unique discussion with Joey Bowen from the Few Will Hunt Show. Together, they dive into the origins and motivations of the Daughter Podcast, its aim to build a community of strong, mindful, and present fathers, and the personal growth both have experienced as dads. The conversation spans the challenges of early fatherhood, the importance of being present for their children, and the continuous journey of self-improvement. Oscar underscores the value of community, learning from peers, and the relentless pursuit of becoming better fathers and men. The episode also explores the deeper impact of these lessons, emphasizing the small moments that shape their roles as parents.The Few Will Hunt ShowDaughtered On the WebOscar on InstagramFew Will Hunt. 10% OFF use GIRLDAD00:00 Introduction to the Daughter Podcast00:14 Special Episode Announcement01:40 Discussing the Podcast's Origins02:16 Challenges of Early Fatherhood03:42 Learning and Growing as a Parent05:26 The Importance of Community07:09 Balancing Work and Family09:57 Creating the Daughter Podcast12:20 The Role of Community in Parenting22:32 Starting Daddy-Daughter Days27:27 The Essence of Necessity28:11 Introducing The Daughter Podcast28:46 The Role of Fathers and Personal Growth30:25 Entrepreneurship and Making a Difference33:44 Reflections on Mortality and Service47:08 The Importance of Being Present53:25 Where to Find The Daughter Podcast55:29 Final Thoughts and GratitudeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The House on Thursday moved to approve the largest-ever cuts to federal safety net programs, the last step before the measure goes to President Donald Trump's desk. After the Senate very narrowly passed the bill, House GOP leaders ushered it past resistance from conservatives wary of adding trillions to the federal debt and moderates concerned about its cuts to Medicaid. Meanwhile, Health and Human Services Secretary Robert F. Kennedy Jr. has continued to pursue his anti-vaccine agenda, despite promises that he would not. Alice Miranda Ollstein of Politico, Maya Goldman of Axios, and Sarah Karlin-Smith of the Pink Sheet join KFF Health News' Julie Rovner to discuss these stories and more. Plus, for “extra credit,” the panelists suggest health policy stories they read this week that they think you should read, too: Julie Rovner: The Lancet's “Evaluating the Impact of Two Decades of USAID Interventions and Projecting the Effects of Defunding on Mortality up to 2030: A Retrospective Impact Evaluation and Forecasting Analysis,” by Daniella Medeiros Cavalcanti, et al. Alice Miranda Ollstein: The New York Times' “‘I Feel Like I've Been Lied To': When a Measles Outbreak Hits Home,” by Eli Saslow. Maya Goldman: Axios' “New Docs Get Schooled in Old Diseases as Vax Rates Fall,” by Tina Reed. Sarah Karlin-Smith: Wired's “Snake Venom, Urine, and a Quest to Live Forever: Inside a Biohacking Conference Emboldened by MAHA,” by Will Bahr. Hosted on Acast. See acast.com/privacy for more information.

In this intimate and illuminating episode of Lifted, Tembi Locke welcomes death doula, attorney, and bestselling author Alua Arthur (Briefly Perfectly Human) for a transformative conversation on embracing the end of life—not as a tragedy, but as a portal to deeper connection, clarity, and purpose. Alua shares her unexpected journey to becoming a death doula, and together, she and Tembi explore what it means to truly live in the presence of death. They discuss the shame that often surrounds grief, the fear of death that permeates Western culture, and the courageous practice of preparing for the end with honesty, dignity, and love. With humor, reverence, and radical compassion, Alua reframes death as not something to resist, but something to welcome as a vital part of being fully human. If you're navigating grief, caregiving, or seeking more intention in how you live and love, this conversation is a sacred invitation to rethink your relationship with death -- and find deeper meaning in the present. Key themes: death and dying, end-of-life planning, grief, legacy, caregiving, mental health, cultural attitudes toward mortality, community, living fully Mentioned: Briefly Perfectly Human, Going with Grace Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episode Overview In this inspiring episode, Steve Stein sits down with acclaimed author and mindset expert Karen Salmansohn for an in-depth conversation about her upcoming book, “Year to Die for Life: How to Maximize Joy and Minimize Regret Before Your Time Runs Out.” Karen and Steve explore how mortality awareness can catalyze a life well-lived, waking us up from autopilot to tap into deeper authenticity, gratitude, and actionable joy. Key Topics Discussed Near Life Experiences vs. Truly Living: Karen explains how many of us go through our days on autopilot—scrolling mindlessly, distracted, and missing out on real, vibrant life. She shares strategies for waking up and savoring every moment. The Power of Mortality Awareness: Inspired by her father's passing, Karen reveals how pondering life's finiteness isn't morbid—it's motivating. Knowing our time is limited helps us act with greater urgency and intention. Writing Your Own Eulogy & “To Die” List: Karen introduces practical exercises like writing your own eulogy (with a fun, Mad Libs-inspired template!) and creating a “To Die List”—a collection of what truly matters most. Core Values for a Meaningful Life: Explore Karen's seven core values (Authentic, Brave, Curious, Discerning, Empathic Love, Fun, Gratitude) and learn how aligning your daily habits with these values helps reduce regret and boost fulfillment. Identity-Based Habits: How embracing positive self-identity and values leads to powerful, lasting behavioral change. Daily Practices to Cultivate Mindfulness: Accessible tools such as gratitude rituals in the morning, “speed bumps” (moments of awareness during the day), visual meditations, and journaling for self-reflection. Mortality Marble Jar: Karen introduces a visual monthly ritual—removing a marble for each month left in your projected life—which brings heightened appreciation and increased mindfulness to each day. Building Meaningful Relationships: Why time spent intentionally with those you love, and the ripples you leave, matter above all else. Practical Takeaways Simple morning meditations to start your day with gratitude and intention How to use speed bumps and discernment to pause and make more meaningful daily choices Fun, engaging habits like the “fun jar” and monthly self-reflection with marbles Journaling prompts to deepen self-awareness and discover what matters most Memorable Quotes “A spoonful of humor helps the psychological tools go down.” “Mortality awareness isn't morbid—it's motivating.” “The more you ‘you' you are, the happier you'll be.” Resources & Links Karen's Website: notsalmon.com Preorder the Book: yourtodieforlife.com SurfingTheTsunami.com – Wisdom Feed Plus Membership Connect with the Show Love this episode? Join the growing community at Wisdom Feed Plus for exclusive access to meditations, expert interviews, and a supportive community to help you stress less and live more. Thank you for tuning in to StreetSmart Wisdom! If you enjoyed this episode, please rate, review, and share the podcast with your friends. See you next time!

What if death isn't inevitable but a solvable problem? This episode explores how biohacking is reshaping our understanding of mortality, legacy, and the limits of human performance. You'll learn why some of today's top thinkers are treating longevity as both a science and a spiritual movement, and how this shift affects your brain, your mitochondria, and your entire approach to life. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with philosopher and best-selling author Dr. Stephen Cave, Director of the Institute for Technology and Humanity at the University of Cambridge. With decades of expertise studying death, immortality, and ethics, Dr. Cave brings a rare depth of insight into how our desire to live longer intersects with neuroplasticity, supplements, and even nootropics. Together, they unpack the four universal immortality narratives, the dangers of mind uploading, and why AI might become humanity's next god or destroyer. You'll discover how legacy, ego, functional medicine, and even fasting and ketosis play into our fear of death. The conversation also dives into the deeper psychological and societal consequences of radical life extension, and what happens when biohacking crosses into belief. This episode is a must-listen for anyone serious about hacking longevity, brain optimization, metabolism, and building a future where living to 180 isn't science fiction. You'll also hear surprising thoughts on Danger Coffee, RFK, sleep optimization, and how to approach mortality using the Smarter Not Harder mindset. You'll Learn: • Why all technology is a form of life extension • How ego and boredom threaten longevity more than disease • The real dangers of digital immortality and uploading consciousness • Why procrastination could be the enemy of eternal life • How to balance transhumanist tech with human values • The surprising connection between cold therapy, supplements, and meaning Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Stephen's Website: https://www.ith.cam.ac.uk/staff/stephen-cave • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:09 Intro • 01:39 Life Extension Challenges • 02:05 Boredom and Mental Health • 04:28 Immortality vs. Enlightenment • 06:21 Death's Role in Civilization • 09:06 Life Stages and Aging • 10:41 Global Immortality Narratives • 15:50 Personal Takes on Immortality • 20:46 Biohacking and Longevity • 28:43 Transhumanism Today • 31:00 Techno-Utopianism and Happiness • 32:20 Wealth and Fulfillment • 32:54 Purpose and Meaning • 34:00 Legacy and Death • 36:33 Near-Death and Mortality • 37:52 Time and Procrastination • 42:00 AI and Human Future • 45:56 Ethics of Life Extension • 50:35 Autonomy and Mortality • 52:35 Dangerous Ideas in Longevity • 55:53 Advice for the Young See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of the Saving Lives Podcast, we review a comprehensive 2025 meta-analysis on mortality risk factors in pulmonary embolism. Learn which clinical signs, biomarkers, and imaging findings most strongly predict outcomes — and how they can guide triage and therapy decisions in acute PE cases. A must-listen for anyone managing thromboembolic disease in the critically ill patients.The Vasopressor & Inotrope HandbookAmazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/47qJZe1⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Affiliate Link)My Store: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://eddyjoemd.myshopify.com/products/the-vasopressor-inotrope-handbook⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Use "podcast" to save 10%)Citation: You W, Fan XY, Chen Y, Wang XL, Song J, Nie CC, Dong Q. Risk Factors for Mortality in Patients with Pulmonary Embolism-A Meta-Analysis. J Intensive Care Med. 2025 May 5:8850666251326539. doi: 10.1177/08850666251326539. Epub ahead of print. PMID: 40320917.

In this episode of Set Lusting Bruce, host Jesse Jackson is joined by guest Marcos Cabanas Maldonado, who reflects on his musical journey and dedication to Bruce Springsteen. Marcos shares insights about his own music, including his latest song 'Racing with Rosie,' collaborating with members of the E Street Band, and the influences behind his writing. The duo also delve into their experiences attending Bruce's concerts, discussing this tour's setlist structure and the political messages embedded in the performances. Listen in for a thoughtful conversation on music, fandom, and the evolving landscape of the music industry. https://marcoscabanas.com/ 00:00 Introduction and Patreon Shoutouts 01:44 Marcos Cabanas Maldonado's Musical Journey 04:54 Discussion on Bruce Springsteen's Lost Albums 19:37 The Challenges of Being a Modern Musician 27:35 Live Concert Experiences and Memories 35:43 Reflecting on Bruce's Mortality and Setlist Choices 36:29 Understanding Fan Expectations and Disappointments 37:47 Historical Context of Bruce's Tours 39:35 Political Views and Their Impact on Fans 40:20 Cultural Differences in Expressing Identity 44:00 Bruce's Political Statements Through Music 51:07 Discussing New Musical Projects 58:12 The Influence of Bruce on Songwriting 01:00:08 Challenges of Autobiographical Songwriting 01:04:48 Promoting Music and Connecting with Fans 01:06:44 Conclusion and Farewell Learn more about your ad choices. Visit megaphone.fm/adchoices

Commentary by Dr. Jian'an Wang.

Send us a textSevere Neonatal Morbidity and All-Cause and Cause-Specific Mortality Through Infancy and Late Adolescence.Graham H, Johansson K, Persson M, Norman M, Razaz N.JAMA Pediatr. 2025 Jun 10:e251873. doi: 10.1001/jamapediatrics.2025.1873. Online ahead of print.PMID: 40493844As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

In this powerful conversation with Dr. Stan Beecham, a renowned psychologist and author of "Elite Minds," we explore the profound insights gained from confronting life's toughest challenges. Having faced acute leukemia and emerged with a renewed perspective on life, Dr. Beecham shares invaluable lessons on resilience, identity, and the power of acceptance. A Journey Through Adversity During the podcast, Dr. Beecham recounts his battle with acute leukemia, reflecting on the ways this life-altering experience informed his approach to living. He emphasises the importance of accepting life's randomness, turning an uncertain future into an opportunity for personal growth. Dr. Beecham's story serves as a testament to the power of acknowledging vulnerability and embracing the present moment. What You'll Learn: Facing Adversity: Discover how confronting life-threatening challenges can lead to a deeper understanding of oneself and enhance appreciation for life's simple pleasures. Resilience and Stoicism: Learn about the role of stoic philosophy in overcoming adversity, including concepts like 'Amor Fati' and the acceptance of fate as a path to liberation from fear. Identity and Self-Reflection: Explore the dangers of tying identity too closely to professional accomplishments and the benefits of cultivating a sense of self beyond work. Focus and Intentional Living: Understand the importance of directing the "flashlight of attention" towards meaningful experiences and relationships. Key Takeaways: Acceptance is vital: Embrace your circumstances as they are, using acceptance as a foundation to focus on what you can control. Cultivate curiosity and urgency: Approach life with a sense of curiosity about what's next and seize opportunities with urgency. Embrace simplicity: Find joy in daily routines and simple pleasures as a way to enrich your life and cultivate mindfulness. Contribute positively: Strive to give more than you take in interactions, fostering positive energy and enriching relationships. Be honest and seek truth: In relationships, tell the truth even when it's difficult, as transparency strengthens connections. Resources: For more insights from Dr. Stan Beecham, explore his book "Elite Minds" available on Amazon. Visit Dr. Stan Beecham's website for further information and resources. Connect with Dr. Stan Beecham: LinkedIn: Dr. Stan Beecham In embracing life's uncertainties, Dr. Stan Beecham reminds us that every challenge is an opportunity to grow and redefine our purpose Support the Podcast: If you found this conversation impactful, please consider subscribing, rating, and leaving a review on your preferred podcast platform. Your support helps us continue to bring you meaningful discussions. Support and Share: Share this episode with those who might benefit from these insights—reflecting on life's challenges can inspire growth and resilience in the most unexpected ways. 00:39 Stan's Leukemia Diagnosis 01:53 Hospital Experience and Personal Resilience 04:24 Reflections on Life and Vulnerability 08:07 Paul's Open Heart Surgery 09:02 Stoic Philosophy and Facing Adversity 10:38 Embracing Fate and Life's Challenges 20:44 Identity Beyond Work 31:16 Survival Situations and Acceptance 34:46 Entitlement and Victim Mentality 35:56 Self-Worth and External Perception 37:52 Compassion and Truth-Telling 43:03 The Importance of Attention 47:45 Facing Mortality and Urgency 52:50 Lessons from Near-Death Experiences 59:47 Living with Purpose and Joy See omnystudio.com/listener for privacy information.

In this episode of the Saving Lives Podcast, we review a 2025 NEJM-Evidence study analyzing over 21,000 cases of severe hyponatremia to determine the safest and most effective correction rates. Learn why moderate correction (8–10 mmol/L/day) may actually reduce mortality, and how central pontine myelinolysis (CPM) remains rare even with faster correction. The Vasopressor & Inotrope HandbookI have written "The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals," a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy. Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/47qJZe1⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Affiliate Link)My Store: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://eddyjoemd.myshopify.com/products/the-vasopressor-inotrope-handbook⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Use "podcast" to save 10%)Citation: Seethapathy H, Zhao S, Ouyang T, Passos C, Sarang A, Cheung PW, Waikar SS, Steele DJR, Kalim S, Allegretti AS, Ayus JC, Nigwekar SU. Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis. NEJM Evid. 2023 Oct;2(10):EVIDoa2300107. doi: 10.1056/EVIDoa2300107. Epub 2023 Sep 26. PMID: 38320180.

In this episode of Set Lusting Bruce, host Jesse Jackson is joined by guest Marcos Cabanas Maldonado, who reflects on his musical journey and dedication to Bruce Springsteen. Marcos shares insights about his own music, including his latest song 'Racing with Rosie,' collaborating with members of the E Street Band, and the influences behind his writing. The duo also delve into their experiences attending Bruce's concerts, discussing this tour's setlist structure and the political messages embedded in the performances. Listen in for a thoughtful conversation on music, fandom, and the evolving landscape of the music industry. https://marcoscabanas.com/ 00:00 Introduction and Patreon Shoutouts 01:44 Marcos Cabanas Maldonado's Musical Journey 04:54 Discussion on Bruce Springsteen's Lost Albums 19:37 The Challenges of Being a Modern Musician 27:35 Live Concert Experiences and Memories 35:43 Reflecting on Bruce's Mortality and Setlist Choices 36:29 Understanding Fan Expectations and Disappointments 37:47 Historical Context of Bruce's Tours 39:35 Political Views and Their Impact on Fans 40:20 Cultural Differences in Expressing Identity 44:00 Bruce's Political Statements Through Music 51:07 Discussing New Musical Projects 58:12 The Influence of Bruce on Songwriting 01:00:08 Challenges of Autobiographical Songwriting 01:04:48 Promoting Music and Connecting with Fans 01:06:44 Conclusion and Farewell Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, Max Stephens shares his journey from a challenging childhood to becoming a coach, speaker, and author. He discusses the importance of self-discovery, understanding one's purpose, and the illusions of success in modern society. Max emphasizes the need for psychological reengineering to align one's life with intrinsic motivations and the significance of contribution to find true fulfillment. He provides insights on building a solid foundation for change, recognizing red flags in one's life, and embracing discomfort as a catalyst for growth.Chapters00:00 Journey to Coaching: A Personal Story05:53 The Quest for Purpose: Understanding Self-Deception11:55 The Illusion of Success: A Critical Examination17:47 Building a Foundation: Forgiveness, Mortality, and Honesty24:08 Gifts and Contribution: Finding Your Purpose Beyond Self29:34 The Importance of Contribution33:38 Psychological Reengineering for Purpose40:01 Transforming Identity and Habits46:09 Intrinsic vs. Extrinsic Motivation

In Episode 6 of the Society of Actuaries Research Institute's podcast series Long-Term Drivers of Future Mortality, Kara Clark is joined by Al Klein, Principal and Consulting Actuary at Milliman, and Erik Pickett, Actuary and Chief Content Officer at Club Vita, to discuss the pivotal role of health care in shaping future mortality outcomes. Drawing from the SOA Research Institute report presented at the 2023 Living to 100 Symposium, this episode dives into Chapter 6, which examines health care systems across the globe—from universal government-funded models to private nonuniversal systems—and their implications for access, treatment, prevention, and long-term outcomes. The conversation explores technological innovation, systemic disparities, and the actuarial lens on future health care challenges.

TODAY'S TREASUREAnd there has not arisen a prophet since in Israel like Moses, whom the Lord knew face to face.Deut. 34:10Send us a comment!Support the show

THE LANCET 2003;362:772-776Background: Angiotensin converting enzyme inhibitors (ACEi) reduce mortality and morbidity in patients with systolic heart failure (see CONSENSUS and SOLVD trials). However, registry data showed that up to 20% of patients with systolic heart failure were not taking ACEi. One of the frequent causes for intolerance to ACEi is cough. Angiotensin converting enzyme inhibitors work by blocking the conversion of angiotensin I to angiotensin II, a key step in the renin–angiotensin–aldosterone system (RAAS). Angiotensin II receptor blockers were tolerated in patients with systolic heart failure who were intolerant to ACEi. However, data on long term effectives as an alternative to ACEi were lacking.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Alternative trial sough to assess if the angiotensin-receptor blocker (ARB) candesartan, could improve outcomes in patients with systolic heart failure who are intolerant to ACEi.Patients: Eligible patients had left ventricular ejection fraction of 40% or less and NYHA class II, III or IV symptoms of at least 4 weeks duration. Patients had also to be intolerant to ACEi.Exclusion criteria were not provided in the main manuscript.Baseline characteristics: Patients were recruited from 618 centers in 26 countries. The trial randomized 2,028 patients – 1,013 randomized to receive candesartan and 1,015 to receive placebo.The average age of patients was 67 years and 68% were men. The average left ventricular ejection fraction was 30%. Cardiomyopathy was ischemic in 68% of the patients. The NYHA class was II in 48% of the patients, III in 49% and IV in 4%.Approximately 50% had hypertension, 27% had diabetes, 61% had prior myocardial infarction, 9% had stroke, 25% had atrial fibrillation and 14% were current smokers.At the time of enrollment, 85% were taking a diuretic, 46% were taking digoxin, 55% were taking beta-blockers and 24% were taking spironolactone.The most common reasons for ACEi intolerance were cough in 72% of the patients, hypotension in 13%, renal dysfunction in 12% and angioedema or anaphylaxis in 4%.Procedures: The trial was double-blinded. Patients were assigned in a 1:1 ratio to receive candesartan starting at 4 or 8mg once daily or placebo. The treatment was doubled every two weeks to a target dose of 32mg once daily.After randomization, follow up occurred at 2, 4, and 6 weeks, 6 months and every 4 months thereafter.Endpoints: The primary outcome was a composite of cardiovascular death or heart failure hospitalizations. All deaths were classified as cardiovascular unless there was a clear non-cardiac cause.Analysis was performed based on the intention-to-treat principle. The estimated sample size to have 80% power at 5% alpha was 2,000 patients. The sample size calculation assumed 18% relative risk reduction in the primary outcome with candesartan assuming a 15% annual event rate in the placebo arm.Results: The median follow up time was 34 months. The mean candesartan daily dose was 23mg at 6 months.Candesartan reduced the primary endpoint of cardiovascular death or heart failure hospitalizations (33.0% vs 40.0%, adjusted HR: 0.70, 95% CI: 0.60 – 0.81; p< 0.001). Candesartan reduced the individual components of the primary outcome - (21.6% vs 24.8%; p= 0.02) for cardiovascular death and (20.4% vs 28.2%; p< 0.001) for heart failure hospitalizations. All-cause death was also lower with candesartan (26.2% vs 29.2%, adjusted HR: 0.83, 95% CI: 0.70–0.99; p= 0.033). The number of patients who had any hospitalization as well as the total number of hospitalizations were numerically but not statistically significantly lower with candesartan (60.2% with candesartan vs 63.3%; p= 0.16) and (1,718 vs 1,835; p= 0.06).Candesartan was associated with more hypotension (3.7% vs 0.9%), more increase in creatinine (6.1% vs 2.7%) and more hyperkalemia (1.9% vs 0.3%). Angioedema occurred in three patients in the candesartan group and none in the placebo group. Cough occurred in two patients taking candesartan and four taking placebo.Authors reported no significant subgroup interactions, however, a corresponding graph was not provided.Conclusion: In patients with systolic heart failure who are intolerant to ACEi, candesartan reduced the primary composite outcome of cardiovascular death or heart failure hospitalizations with a number needed to treat of approximately of 14 patients over 34 months of follow up. Candesartan also reduced all-cause death with a number needed to treat of approximately 33 patients. Adverse events including hypotension, increase in creatinine and hyperkalemia were more common with candesartan.The reduction in the primary endpoint with candesartan was significant and offers an alternative for patients who are unable to tolerate ACEi. Of note, 72% of the patients enrolled in the trial were intolerant to ACEi due to cough. This trial did not include a head-to-head comparison between ARBs and ACEi, and therefore does not address which agent should be preferred as first-line therapy. Only 24% of participants were receiving spironolactone. The combination of ARBs with spironolactone, may increase the risk of adverse events, particularly hyperkalemia and kidney injury.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter BJ Miller, a hospice and palliative care physician, and Bridget Sumser, a licensed social worker specializing in serious illness and end-of-life care, join Peter to share insights from their decades of work supporting people at the end of life. In this episode, they explore the emotional and physiological processes of dying, the cultural barriers that prevent meaningful conversations about death, and how early engagement with mortality can lead to greater clarity and connection. The conversation highlights the distinctions between hospice and palliative care, the nature of suffering beyond physical pain, and the transformative role of honesty, forgiveness, and relational awareness in the dying process. Through stories and reflections, BJ and Bridget reveal what truly matters in the end—and how the dying can teach the living not only how to face death but how to live more fully. We discuss: The personal journeys of BJ and Bridget into end-of-life care, and the connection between living and dying [3:30]; What dying looks like: the physical, cognitive, and emotional realities at the end of life [13:15]; How historical perspectives on death contrast with modern experiences of dying [25:30]; The difference between palliative care and hospice care [30:45]; The systemic challenges surrounding hospice care: why patients often enter it too late to receive its full benefits [35:30]; How delayed hospice referrals and unspoken preferences often prevent patients from dying where and how they truly want [39:30]; The realities of home hospice: challenges, costs, and burdens placed of families [43:45]; How proactively engaging with the reality of death can avoid unnecessary suffering and promote a more peaceful ending [53:30]; How palliative care is misunderstood and underutilized—especially in cancer care [1:02:45]; Palliative care in the case of Alzheimer's disease: emotional support, future planning, and family involvement [1:12:15]; The importance of having an advance directive: defining what matters most before it's too late [1:23:00]; The differences between how young and old individuals experience dying from cancer [1:30:15]; The difference between pain and suffering, role of medicine in pain relief, and why emotional healing is essential at the end of life [1:35:45]; Dying well: the power of self-honesty and human connection at the end of life [1:47:00]; How psychedelics like psilocybin can unlock emotional breakthroughs and deepen connection for patients near the end of life [1:55:15]; Lessons from the dying on how to live well [1:57:30]; The physical process of active dying, and the emotional and practical considerations for loved ones [2:09:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this debut episode of JACC This Week with Editor-in-Chief Dr. Harlan Krumholz, we explore groundbreaking studies and timely insights from the July 1st issue. Highlights include the impact of wildfire smoke on heart failure risk, new hemodynamic data on mechanical circulatory support in cardiogenic shock, and sobering cardiovascular mortality trends over the past 25 years. Plus, updates on aspirin use, cognitive impairment in CVD, ACC/AHA performance measures, and a leadership reflection from ACC President Dr. Christopher Kramer.

Today's guest is Nicole Nodal-Rogriguez, MSN, RN, CCDS, CDI education specialist at HCPro/ACDIS. Today's show is part of the “Talking CDI” series, hosted by ACDIS Director Rebecca Hendren. Our intro and outro music for the ACDIS Podcast is “medianoche” by Dee Yan-Kay and our ad music is “Take Me Higher” by Jahzzar, both obtained from the Free Music Archive. Have questions about today's show or ideas for a future episode? Contact the ACDIS team at info@acdis.org. Want to submit a question for a future "listener questions" episode? Fill out this brief form!  CEU info: Each ACDIS Podcast episode now offers 0.5 ACDIS CEU which can be used toward recertifying your CCDS or CCDS-O credential for those who listen to the show in the first two days from the time of publication. To receive your 0.5 CEU, go to the show page on acdis.org, by clicking on the “ACDIS Podcast” link located under the “Free Resources” tab. To take the evaluation, click the most recent episode from the list on the podcast homepage, view the podcast recording at the bottom of that show page, and click the live link at the very end after the music has ended. Your certificate will be automatically emailed to you upon submitting the brief evaluation. (Note: If you are listening via a podcast app, click this link to go directly to the show page on acdis.org: https://acdis.org/acdis-podcast/listener-questions-queries-coding-shortages-ai-mortality-reviews) Note: To ensure your certificate reaches you and does not get trapped in your organization's spam filters, please use a personal email address when completing the CEU evaluation form. The cut-off for today's episode CEU is Friday, June 20, 2025, at 11:00 p.m. Eastern. After that point, the CEU period will close, and you will not be eligible for the 0.5 CEU for this week's episode. Today's sponsor: Today's show is brought to you by ACDIS Encore: Clinical & Coding Online, a special virtual event featuring sessions recorded live during the 2025 ADCIS conference—the entire Clinical & Coding track, happening August 12-14, 2025. Learn more and register here: https://bit.ly/3SKItN6 ACDIS update: Respond to the 2025 CDI Week Industry Survey by July 18! (https://www.surveymonkey.com/r/2025-CDI-Week-Industry-Survey) Apply for one of ACDIS' committees by June 30! (https://www.surveymonkey.com/r/June-2025-ACDIS-committees) Apply to speak at one of ACDIS' 2026 events, including the 2026 ACDIS Conference, by July 21! (https://bit.ly/4jLYDkr)

Welcome back to the Longevity Podcast! In this episode, I have the pleasure of sitting down with James Strole, a beacon in the radical longevity space and the visionary founder behind People Unlimited and RAADfest. James shares the personal journey that led him into the world of life extension—shaped by a spiritually open-minded mother, a pivotal loss, and a lifelong desire to challenge the idea that aging is inevitable. Get 10% off your tickets to RAADfest using code: "niddam"   What we discuss: James Strole's personal journey to radical longevity ... 00:04:00 Spiritual roots and early inspiration ... 00:10:00 Transition from spiritual to scientific approaches ... 00:13:00 Launching RAADfest and the shift toward hard science ... 00:16:00 Evolution of the longevity movement over the decade ... 00:21:00 Access to longevity innovations and RAAD Clinics ... 00:22:00 Most exciting developments: gene therapy and age reversal ... 00:24:00 Daily longevity pillars: diet, movement, mindset ... 00:26:00 Mindset and embracing the possibility of immortality ... 00:35:00 Overcoming skepticism and “against nature” arguments ... 00:41:00 Societal implications of extreme longevity ... 00:44:00 Are we at the tipping point? The “era of immortality” ... 00:47:00 Advice for newcomers: join the conversation and community ... 00:50:00   Our Amazing Sponsors: NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. Mitoblue by Wizard Sciences - Everything in the formula is there to help you think clearer, move better, and stay resilient—mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase. Mimio: A supplement that gives you all the cellular, metabolic, and longevity benefits of a prolonged fast—even on the days when you're eating normally. Visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Mortality gets a little bit closer for the baby boomer generation. Learn more about your ad choices. Visit megaphone.fm/adchoices

*Content warning: birth trauma, medical trauma, medical neglect, racism, death of an infant, infant loss, death, maternal loss, mature and stressful themes.*Free + Confidential Resources + Safety Tips: somethingwaswrong.com/resources Center for Black Maternal Health & Reproductive Justice:https://blackmaternalhealth.tufts.edu/Center for Black Maternal Health & Reproductive Justice Instagram:https://www.instagram.com/cbmhrj_tufts/Center for Black Maternal Health & Reproductive Justice Facebook:https://www.facebook.com/CBMHRJTufts/Center for Black Maternal Health & Reproductive Justice LinkedIn:https://www.linkedin.com/company/cbmhrjtufts/Sources: Addressing Transportation Barriers to Improve Healthcare Access in Arizonahttps://repository.arizona.edu/handle/10150/674794 Advancing Health Equity and Value-Based Care: A Mobile Approachhttps://info.primarycare.hms.harvard.edu/perspectives/articles/mobile-clinics-in-the-us-health-system#:~:text=Mobileclinicsareaproven,thecriticalweeksafterbirth American College of Nurse Midwiveshttps://midwife.org/ American College of Obstetricians and Gynecologists (ACOG)https://www.acog.org/ Birth Centers in Massachusettshttps://baystatebirth.org/birth-centers A Brief History of Midwifery in Americahttps://www.ohsu.edu/womens-health/brief-history-midwifery-america Clinical outcomes improve when patient's and surgeon's ethnicity match, study showshttps://www.uclahealth.org/news/article/clinical-outcomes-patients-surgeons-concordanceThe Controversial Birth of American Gynecologyhttps://researchblog.duke.edu/2023/10/27/the-controversial-birth-of-american-gynecology/ 'Father Of Gynecology,' Who Experimented On Slaves, No Longer On Pedestal In NYChttps://www.npr.org/sections/thetwo-way/2018/04/17/603163394/-father-of-gynecology-who-experimented-on-slaves-no-longer-on-pedestal-in-nyc Governor Healey Signs Maternal Health Bill, Expanding Access to Midwifery, Birth Centers and Doulas in Massachusettshttps://www.mass.gov/news/governor-healey-signs-maternal-health-bill-expanding-access-to-midwifery-birth-centers-and-doulas-in-massachusetts#:~:text=GovernorHealeySignsMaternalHealthBillCExpanding,ExecutiveOfficeofHealthandHumanServices Governor Murphy Signs Bill Establishing Maternal and Infant Health Innovation Centerhttps://www.nj.gov/governor/news/news/562023/approved/20230717a.shtml Helping Mothers and Children Thrive: Rethinking CMS's Transforming Maternal Health (TMaH) Modelhttps://www.milbank.org/quarterly/opinions/helping-mothers-and-children-thrive-rethinking-cmss-transforming-maternal-health-tmah-model/#:~:text=TheTransformingMaternalHealth(TMaH)Model&text=TheTMaHModelfocuseson,midwiferyservicesanddoulacare The Historical Significance of Doulas and Midwiveshttps://nmaahc.si.edu/explore/stories/historical-significance-doulas-and-midwivesInfant Health and Mortality and Black/African Americanhttps://minorityhealth.hhs.gov/infant-health-and-mortality-and-blackafrican-americans#:~:text=In2022%2Ctheinfantmortality,Figure2 Legislature Passes Comprehensive Maternal Health Billhttps://malegislature.gov/PressRoom/Detail?pressReleaseId=136Life Story: Anarcha, Betsy, and Lucyhttps://wams.nyhistory.org/a-nation-divided/antebellum/anarcha-betsy-lucy/Management of Postpartum Hemorrhage in Low- and Middle-Income Countries: Emergency Need for Updated Approach Due to Specific Circumstances, Resources, and Availabilitieshttps://pmc.ncbi.nlm.nih.gov/articles/PMC11643001/#:~:text=EtiologyandRiskFactorsof,insufficienttreatment%E2%80%9D%5B50%5D March of Dimeshttps://www.marchofdimes.org/peristats/about-us Maternity Care Deserthttps://www.marchofdimes.org/peristats/data?top=23 Maternal deaths and mortality rates by state, 2018-2022https://www.cdc.gov/nchs/maternal-mortality/mmr-2018-2022-state-data.pdf Maternal Mortality in the United States After Abortion Banshttps://thegepi.org/maternal-mortality-abortion-bans/#:~:text=In2023%2CTexas'smaternalmortality,suffermaternaldeathin2023 Maternal Mortality in the U.S Declined, though Disparities in the Black Population Persisthttps://policycentermmh.org/maternal-mortality-in-the-u-s-a-declining-trend-with-persistent-racial-disparities-in-the-black-population/Maternal Mortality Is on the Rise: 8 Things To Knowhttps://www.yalemedicine.org/news/maternal-mortality-on-the-rise Maternal Mortality: How the U.S. Compares to Other Rich Countrieshttps://www.usnews.com/news/best-countries/articles/2024-06-04/how-the-u-s-compares-to-other-rich-countries-in-maternal-mortalityMaternal Mortality Rates in the United States, 2021https://www.cdc.gov/nchs/data/hestat/maternal-mortality/2021/maternal-mortality-rates-2021.htm#:~:text=In2021%2C1%2C205womendied,20.1in2019(Table) Medical Exploitation of Black Womenhttps://eji.org/news/history-racial-injustice-medical-exploitation-of-black-women/National Midwifery Institutehttps://www.nationalmidwiferyinstitute.com/midwifery National Counsel of State Boards of Nursinghttps://www.ncsbn.org/North American Registry of Midwives (NARM)https://narm.org/ Outcome of subsequent pregnancies in women with complete uterine rupture: A population-based case–control studyhttps://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/aogs.14338#:~:text=outcomesarerare.-,1INTRODUCTION,experienceacompleteuterinerupture.&text=Completeuterineruptureisdefined,completeruptureofthemyometrium Pregnancy-Related Deaths: Data From Maternal Mortality Review Committees in 36 U.S. States, 2017–2019https://www.cdc.gov/maternal-mortality/php/data-research/mmrc-2017-2019.html Preterm Birthhttps://www.cdc.gov/maternal-infant-health/preterm-birth/index.html#:~:text=Pretermbirthrates&text=In2022%2Cpretermbirthamong,orHispanicwomen(10.1%25) Racial Disparities in Maternal and Infant Health: Current Status and Efforts to Address Themhttps://www.kff.org/racial-equity-and-health-policy/issue-brief/racial-disparities-in-maternal-and-infant-health-current-status-and-efforts-to-address-them/The Racist History of Abortion and Midwifery Banshttps://www.aclu.org/news/racial-justice/the-racist-history-of-abortion-and-midwifery-bans Reducing Disparities in Severe Maternal Morbidity and Mortalityhttps://pmc.ncbi.nlm.nih.gov/articles/PMC5915910/#:~:text=Severemorbidityposesanenormous,ofseverematernalmorbidityevents State investigating Dallas birth center and midwives, following multiple complaints from patientshttps://www.wfaa.com/article/news/local/investigates/state-investigating-dallas-birth-center-midwives-following-multiple-complaints-from-patients/287-ea77eb18-c637-44d4-aaa2-fe8fd7a2fcef The State of Telehealth Before and After the COVID-19 Pandemichttps://pmc.ncbi.nlm.nih.gov/articles/PMC9035352/ Texas Department of Licensing and Regulation (TDLR)https://www.tdlr.texas.gov/ U.S. maternal death rate increasing at an alarming ratehttps://news.northwestern.edu/stories/2024/03/u-s-maternal-death-rate-increasing-at-an-alarming-rate/Which states have the highest maternal mortality rates?https://usafacts.org/articles/which-states-have-the-highest-maternal-mortality-rates/ Why Equitable Access to Vaginal Birth Requires Abolition of Race-Based Medicinehttps://journalofethics.ama-assn.org/article/why-equitable-access-vaginal-birth-requires-abolition-race-based-medicine/2022-03 Zucker School of Medicine, Amos Grunebaum, MDhttps://faculty.medicine.hofstra.edu/13732-amos-grunebaum/publications *SWW S23 Theme Song & Artwork: Thank you so much to Emily Wolfe for covering Glad Rag's original song, U Think U for us this season!Hear more from Emily Wolfe:On SpotifyOn Apple Musichttps://www.emilywolfemusic.com/instagram.com/emilywolfemusicGlad Rags: https://www.gladragsmusic.com/ The S23 cover art is by the Amazing Sara StewartFollow Something Was Wrong:Website: somethingwaswrong.com IG: instagram.com/somethingwaswrongpodcastTikTok: tiktok.com/@somethingwaswrongpodcast Follow Tiffany Reese:Website: tiffanyreese.me IG: instagram.com/lookiebooSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.