Podcasts about Mortality

In this special episode of the Daughter Podcast, Oscar reflects on a unique discussion with Joey Bowen from the Few Will Hunt Show. Together, they dive into the origins and motivations of the Daughter Podcast, its aim to build a community of strong, mindful, and present fathers, and the personal growth both have experienced as dads. The conversation spans the challenges of early fatherhood, the importance of being present for their children, and the continuous journey of self-improvement. Oscar underscores the value of community, learning from peers, and the relentless pursuit of becoming better fathers and men. The episode also explores the deeper impact of these lessons, emphasizing the small moments that shape their roles as parents.The Few Will Hunt ShowDaughtered On the WebOscar on InstagramFew Will Hunt. 10% OFF use GIRLDAD00:00 Introduction to the Daughter Podcast00:14 Special Episode Announcement01:40 Discussing the Podcast's Origins02:16 Challenges of Early Fatherhood03:42 Learning and Growing as a Parent05:26 The Importance of Community07:09 Balancing Work and Family09:57 Creating the Daughter Podcast12:20 The Role of Community in Parenting22:32 Starting Daddy-Daughter Days27:27 The Essence of Necessity28:11 Introducing The Daughter Podcast28:46 The Role of Fathers and Personal Growth30:25 Entrepreneurship and Making a Difference33:44 Reflections on Mortality and Service47:08 The Importance of Being Present53:25 Where to Find The Daughter Podcast55:29 Final Thoughts and GratitudeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The House on Thursday moved to approve the largest-ever cuts to federal safety net programs, the last step before the measure goes to President Donald Trump's desk. After the Senate very narrowly passed the bill, House GOP leaders ushered it past resistance from conservatives wary of adding trillions to the federal debt and moderates concerned about its cuts to Medicaid. Meanwhile, Health and Human Services Secretary Robert F. Kennedy Jr. has continued to pursue his anti-vaccine agenda, despite promises that he would not. Alice Miranda Ollstein of Politico, Maya Goldman of Axios, and Sarah Karlin-Smith of the Pink Sheet join KFF Health News' Julie Rovner to discuss these stories and more. Plus, for “extra credit,” the panelists suggest health policy stories they read this week that they think you should read, too: Julie Rovner: The Lancet's “Evaluating the Impact of Two Decades of USAID Interventions and Projecting the Effects of Defunding on Mortality up to 2030: A Retrospective Impact Evaluation and Forecasting Analysis,” by Daniella Medeiros Cavalcanti, et al. Alice Miranda Ollstein: The New York Times' “‘I Feel Like I've Been Lied To': When a Measles Outbreak Hits Home,” by Eli Saslow. Maya Goldman: Axios' “New Docs Get Schooled in Old Diseases as Vax Rates Fall,” by Tina Reed. Sarah Karlin-Smith: Wired's “Snake Venom, Urine, and a Quest to Live Forever: Inside a Biohacking Conference Emboldened by MAHA,” by Will Bahr. Hosted on Acast. See acast.com/privacy for more information.

In this intimate and illuminating episode of Lifted, Tembi Locke welcomes death doula, attorney, and bestselling author Alua Arthur (Briefly Perfectly Human) for a transformative conversation on embracing the end of life—not as a tragedy, but as a portal to deeper connection, clarity, and purpose. Alua shares her unexpected journey to becoming a death doula, and together, she and Tembi explore what it means to truly live in the presence of death. They discuss the shame that often surrounds grief, the fear of death that permeates Western culture, and the courageous practice of preparing for the end with honesty, dignity, and love. With humor, reverence, and radical compassion, Alua reframes death as not something to resist, but something to welcome as a vital part of being fully human. If you're navigating grief, caregiving, or seeking more intention in how you live and love, this conversation is a sacred invitation to rethink your relationship with death -- and find deeper meaning in the present. Key themes: death and dying, end-of-life planning, grief, legacy, caregiving, mental health, cultural attitudes toward mortality, community, living fully Mentioned: Briefly Perfectly Human, Going with Grace Learn more about your ad choices. Visit podcastchoices.com/adchoices

What if death isn't inevitable but a solvable problem? This episode explores how biohacking is reshaping our understanding of mortality, legacy, and the limits of human performance. You'll learn why some of today's top thinkers are treating longevity as both a science and a spiritual movement, and how this shift affects your brain, your mitochondria, and your entire approach to life. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with philosopher and best-selling author Dr. Stephen Cave, Director of the Institute for Technology and Humanity at the University of Cambridge. With decades of expertise studying death, immortality, and ethics, Dr. Cave brings a rare depth of insight into how our desire to live longer intersects with neuroplasticity, supplements, and even nootropics. Together, they unpack the four universal immortality narratives, the dangers of mind uploading, and why AI might become humanity's next god or destroyer. You'll discover how legacy, ego, functional medicine, and even fasting and ketosis play into our fear of death. The conversation also dives into the deeper psychological and societal consequences of radical life extension, and what happens when biohacking crosses into belief. This episode is a must-listen for anyone serious about hacking longevity, brain optimization, metabolism, and building a future where living to 180 isn't science fiction. You'll also hear surprising thoughts on Danger Coffee, RFK, sleep optimization, and how to approach mortality using the Smarter Not Harder mindset. You'll Learn: • Why all technology is a form of life extension • How ego and boredom threaten longevity more than disease • The real dangers of digital immortality and uploading consciousness • Why procrastination could be the enemy of eternal life • How to balance transhumanist tech with human values • The surprising connection between cold therapy, supplements, and meaning Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Stephen's Website: https://www.ith.cam.ac.uk/staff/stephen-cave • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:09 Intro • 01:39 Life Extension Challenges • 02:05 Boredom and Mental Health • 04:28 Immortality vs. Enlightenment • 06:21 Death's Role in Civilization • 09:06 Life Stages and Aging • 10:41 Global Immortality Narratives • 15:50 Personal Takes on Immortality • 20:46 Biohacking and Longevity • 28:43 Transhumanism Today • 31:00 Techno-Utopianism and Happiness • 32:20 Wealth and Fulfillment • 32:54 Purpose and Meaning • 34:00 Legacy and Death • 36:33 Near-Death and Mortality • 37:52 Time and Procrastination • 42:00 AI and Human Future • 45:56 Ethics of Life Extension • 50:35 Autonomy and Mortality • 52:35 Dangerous Ideas in Longevity • 55:53 Advice for the Young See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of the Saving Lives Podcast, we review a comprehensive 2025 meta-analysis on mortality risk factors in pulmonary embolism. Learn which clinical signs, biomarkers, and imaging findings most strongly predict outcomes — and how they can guide triage and therapy decisions in acute PE cases. A must-listen for anyone managing thromboembolic disease in the critically ill patients.The Vasopressor & Inotrope HandbookAmazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/47qJZe1⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Affiliate Link)My Store: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://eddyjoemd.myshopify.com/products/the-vasopressor-inotrope-handbook⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Use "podcast" to save 10%)Citation: You W, Fan XY, Chen Y, Wang XL, Song J, Nie CC, Dong Q. Risk Factors for Mortality in Patients with Pulmonary Embolism-A Meta-Analysis. J Intensive Care Med. 2025 May 5:8850666251326539. doi: 10.1177/08850666251326539. Epub ahead of print. PMID: 40320917.

In this episode of Set Lusting Bruce, host Jesse Jackson is joined by guest Marcos Cabanas Maldonado, who reflects on his musical journey and dedication to Bruce Springsteen. Marcos shares insights about his own music, including his latest song 'Racing with Rosie,' collaborating with members of the E Street Band, and the influences behind his writing. The duo also delve into their experiences attending Bruce's concerts, discussing this tour's setlist structure and the political messages embedded in the performances. Listen in for a thoughtful conversation on music, fandom, and the evolving landscape of the music industry. https://marcoscabanas.com/ 00:00 Introduction and Patreon Shoutouts 01:44 Marcos Cabanas Maldonado's Musical Journey 04:54 Discussion on Bruce Springsteen's Lost Albums 19:37 The Challenges of Being a Modern Musician 27:35 Live Concert Experiences and Memories 35:43 Reflecting on Bruce's Mortality and Setlist Choices 36:29 Understanding Fan Expectations and Disappointments 37:47 Historical Context of Bruce's Tours 39:35 Political Views and Their Impact on Fans 40:20 Cultural Differences in Expressing Identity 44:00 Bruce's Political Statements Through Music 51:07 Discussing New Musical Projects 58:12 The Influence of Bruce on Songwriting 01:00:08 Challenges of Autobiographical Songwriting 01:04:48 Promoting Music and Connecting with Fans 01:06:44 Conclusion and Farewell Learn more about your ad choices. Visit megaphone.fm/adchoices

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Meihan Guo.

Send us a textSevere Neonatal Morbidity and All-Cause and Cause-Specific Mortality Through Infancy and Late Adolescence.Graham H, Johansson K, Persson M, Norman M, Razaz N.JAMA Pediatr. 2025 Jun 10:e251873. doi: 10.1001/jamapediatrics.2025.1873. Online ahead of print.PMID: 40493844As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

In this powerful conversation with Dr. Stan Beecham, a renowned psychologist and author of "Elite Minds," we explore the profound insights gained from confronting life's toughest challenges. Having faced acute leukemia and emerged with a renewed perspective on life, Dr. Beecham shares invaluable lessons on resilience, identity, and the power of acceptance. A Journey Through Adversity During the podcast, Dr. Beecham recounts his battle with acute leukemia, reflecting on the ways this life-altering experience informed his approach to living. He emphasises the importance of accepting life's randomness, turning an uncertain future into an opportunity for personal growth. Dr. Beecham's story serves as a testament to the power of acknowledging vulnerability and embracing the present moment. What You'll Learn: Facing Adversity: Discover how confronting life-threatening challenges can lead to a deeper understanding of oneself and enhance appreciation for life's simple pleasures. Resilience and Stoicism: Learn about the role of stoic philosophy in overcoming adversity, including concepts like 'Amor Fati' and the acceptance of fate as a path to liberation from fear. Identity and Self-Reflection: Explore the dangers of tying identity too closely to professional accomplishments and the benefits of cultivating a sense of self beyond work. Focus and Intentional Living: Understand the importance of directing the "flashlight of attention" towards meaningful experiences and relationships. Key Takeaways: Acceptance is vital: Embrace your circumstances as they are, using acceptance as a foundation to focus on what you can control. Cultivate curiosity and urgency: Approach life with a sense of curiosity about what's next and seize opportunities with urgency. Embrace simplicity: Find joy in daily routines and simple pleasures as a way to enrich your life and cultivate mindfulness. Contribute positively: Strive to give more than you take in interactions, fostering positive energy and enriching relationships. Be honest and seek truth: In relationships, tell the truth even when it's difficult, as transparency strengthens connections. Resources: For more insights from Dr. Stan Beecham, explore his book "Elite Minds" available on Amazon. Visit Dr. Stan Beecham's website for further information and resources. Connect with Dr. Stan Beecham: LinkedIn: Dr. Stan Beecham In embracing life's uncertainties, Dr. Stan Beecham reminds us that every challenge is an opportunity to grow and redefine our purpose Support the Podcast: If you found this conversation impactful, please consider subscribing, rating, and leaving a review on your preferred podcast platform. Your support helps us continue to bring you meaningful discussions. Support and Share: Share this episode with those who might benefit from these insights—reflecting on life's challenges can inspire growth and resilience in the most unexpected ways. 00:39 Stan's Leukemia Diagnosis 01:53 Hospital Experience and Personal Resilience 04:24 Reflections on Life and Vulnerability 08:07 Paul's Open Heart Surgery 09:02 Stoic Philosophy and Facing Adversity 10:38 Embracing Fate and Life's Challenges 20:44 Identity Beyond Work 31:16 Survival Situations and Acceptance 34:46 Entitlement and Victim Mentality 35:56 Self-Worth and External Perception 37:52 Compassion and Truth-Telling 43:03 The Importance of Attention 47:45 Facing Mortality and Urgency 52:50 Lessons from Near-Death Experiences 59:47 Living with Purpose and Joy See omnystudio.com/listener for privacy information.

In this episode of the Saving Lives Podcast, we review a 2025 NEJM-Evidence study analyzing over 21,000 cases of severe hyponatremia to determine the safest and most effective correction rates. Learn why moderate correction (8–10 mmol/L/day) may actually reduce mortality, and how central pontine myelinolysis (CPM) remains rare even with faster correction. The Vasopressor & Inotrope HandbookI have written "The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals," a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy. Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://amzn.to/47qJZe1⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Affiliate Link)My Store: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://eddyjoemd.myshopify.com/products/the-vasopressor-inotrope-handbook⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Use "podcast" to save 10%)Citation: Seethapathy H, Zhao S, Ouyang T, Passos C, Sarang A, Cheung PW, Waikar SS, Steele DJR, Kalim S, Allegretti AS, Ayus JC, Nigwekar SU. Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis. NEJM Evid. 2023 Oct;2(10):EVIDoa2300107. doi: 10.1056/EVIDoa2300107. Epub 2023 Sep 26. PMID: 38320180.

In this episode of Set Lusting Bruce, host Jesse Jackson is joined by guest Marcos Cabanas Maldonado, who reflects on his musical journey and dedication to Bruce Springsteen. Marcos shares insights about his own music, including his latest song 'Racing with Rosie,' collaborating with members of the E Street Band, and the influences behind his writing. The duo also delve into their experiences attending Bruce's concerts, discussing this tour's setlist structure and the political messages embedded in the performances. Listen in for a thoughtful conversation on music, fandom, and the evolving landscape of the music industry. https://marcoscabanas.com/ 00:00 Introduction and Patreon Shoutouts 01:44 Marcos Cabanas Maldonado's Musical Journey 04:54 Discussion on Bruce Springsteen's Lost Albums 19:37 The Challenges of Being a Modern Musician 27:35 Live Concert Experiences and Memories 35:43 Reflecting on Bruce's Mortality and Setlist Choices 36:29 Understanding Fan Expectations and Disappointments 37:47 Historical Context of Bruce's Tours 39:35 Political Views and Their Impact on Fans 40:20 Cultural Differences in Expressing Identity 44:00 Bruce's Political Statements Through Music 51:07 Discussing New Musical Projects 58:12 The Influence of Bruce on Songwriting 01:00:08 Challenges of Autobiographical Songwriting 01:04:48 Promoting Music and Connecting with Fans 01:06:44 Conclusion and Farewell Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, Max Stephens shares his journey from a challenging childhood to becoming a coach, speaker, and author. He discusses the importance of self-discovery, understanding one's purpose, and the illusions of success in modern society. Max emphasizes the need for psychological reengineering to align one's life with intrinsic motivations and the significance of contribution to find true fulfillment. He provides insights on building a solid foundation for change, recognizing red flags in one's life, and embracing discomfort as a catalyst for growth.Chapters00:00 Journey to Coaching: A Personal Story05:53 The Quest for Purpose: Understanding Self-Deception11:55 The Illusion of Success: A Critical Examination17:47 Building a Foundation: Forgiveness, Mortality, and Honesty24:08 Gifts and Contribution: Finding Your Purpose Beyond Self29:34 The Importance of Contribution33:38 Psychological Reengineering for Purpose40:01 Transforming Identity and Habits46:09 Intrinsic vs. Extrinsic Motivation

In Episode 6 of the Society of Actuaries Research Institute's podcast series Long-Term Drivers of Future Mortality, Kara Clark is joined by Al Klein, Principal and Consulting Actuary at Milliman, and Erik Pickett, Actuary and Chief Content Officer at Club Vita, to discuss the pivotal role of health care in shaping future mortality outcomes. Drawing from the SOA Research Institute report presented at the 2023 Living to 100 Symposium, this episode dives into Chapter 6, which examines health care systems across the globe—from universal government-funded models to private nonuniversal systems—and their implications for access, treatment, prevention, and long-term outcomes. The conversation explores technological innovation, systemic disparities, and the actuarial lens on future health care challenges.

TODAY'S TREASUREAnd there has not arisen a prophet since in Israel like Moses, whom the Lord knew face to face.Deut. 34:10Send us a comment!Support the show

THE LANCET 2003;362:772-776Background: Angiotensin converting enzyme inhibitors (ACEi) reduce mortality and morbidity in patients with systolic heart failure (see CONSENSUS and SOLVD trials). However, registry data showed that up to 20% of patients with systolic heart failure were not taking ACEi. One of the frequent causes for intolerance to ACEi is cough. Angiotensin converting enzyme inhibitors work by blocking the conversion of angiotensin I to angiotensin II, a key step in the renin–angiotensin–aldosterone system (RAAS). Angiotensin II receptor blockers were tolerated in patients with systolic heart failure who were intolerant to ACEi. However, data on long term effectives as an alternative to ACEi were lacking.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Alternative trial sough to assess if the angiotensin-receptor blocker (ARB) candesartan, could improve outcomes in patients with systolic heart failure who are intolerant to ACEi.Patients: Eligible patients had left ventricular ejection fraction of 40% or less and NYHA class II, III or IV symptoms of at least 4 weeks duration. Patients had also to be intolerant to ACEi.Exclusion criteria were not provided in the main manuscript.Baseline characteristics: Patients were recruited from 618 centers in 26 countries. The trial randomized 2,028 patients – 1,013 randomized to receive candesartan and 1,015 to receive placebo.The average age of patients was 67 years and 68% were men. The average left ventricular ejection fraction was 30%. Cardiomyopathy was ischemic in 68% of the patients. The NYHA class was II in 48% of the patients, III in 49% and IV in 4%.Approximately 50% had hypertension, 27% had diabetes, 61% had prior myocardial infarction, 9% had stroke, 25% had atrial fibrillation and 14% were current smokers.At the time of enrollment, 85% were taking a diuretic, 46% were taking digoxin, 55% were taking beta-blockers and 24% were taking spironolactone.The most common reasons for ACEi intolerance were cough in 72% of the patients, hypotension in 13%, renal dysfunction in 12% and angioedema or anaphylaxis in 4%.Procedures: The trial was double-blinded. Patients were assigned in a 1:1 ratio to receive candesartan starting at 4 or 8mg once daily or placebo. The treatment was doubled every two weeks to a target dose of 32mg once daily.After randomization, follow up occurred at 2, 4, and 6 weeks, 6 months and every 4 months thereafter.Endpoints: The primary outcome was a composite of cardiovascular death or heart failure hospitalizations. All deaths were classified as cardiovascular unless there was a clear non-cardiac cause.Analysis was performed based on the intention-to-treat principle. The estimated sample size to have 80% power at 5% alpha was 2,000 patients. The sample size calculation assumed 18% relative risk reduction in the primary outcome with candesartan assuming a 15% annual event rate in the placebo arm.Results: The median follow up time was 34 months. The mean candesartan daily dose was 23mg at 6 months.Candesartan reduced the primary endpoint of cardiovascular death or heart failure hospitalizations (33.0% vs 40.0%, adjusted HR: 0.70, 95% CI: 0.60 – 0.81; p< 0.001). Candesartan reduced the individual components of the primary outcome - (21.6% vs 24.8%; p= 0.02) for cardiovascular death and (20.4% vs 28.2%; p< 0.001) for heart failure hospitalizations. All-cause death was also lower with candesartan (26.2% vs 29.2%, adjusted HR: 0.83, 95% CI: 0.70–0.99; p= 0.033). The number of patients who had any hospitalization as well as the total number of hospitalizations were numerically but not statistically significantly lower with candesartan (60.2% with candesartan vs 63.3%; p= 0.16) and (1,718 vs 1,835; p= 0.06).Candesartan was associated with more hypotension (3.7% vs 0.9%), more increase in creatinine (6.1% vs 2.7%) and more hyperkalemia (1.9% vs 0.3%). Angioedema occurred in three patients in the candesartan group and none in the placebo group. Cough occurred in two patients taking candesartan and four taking placebo.Authors reported no significant subgroup interactions, however, a corresponding graph was not provided.Conclusion: In patients with systolic heart failure who are intolerant to ACEi, candesartan reduced the primary composite outcome of cardiovascular death or heart failure hospitalizations with a number needed to treat of approximately of 14 patients over 34 months of follow up. Candesartan also reduced all-cause death with a number needed to treat of approximately 33 patients. Adverse events including hypotension, increase in creatinine and hyperkalemia were more common with candesartan.The reduction in the primary endpoint with candesartan was significant and offers an alternative for patients who are unable to tolerate ACEi. Of note, 72% of the patients enrolled in the trial were intolerant to ACEi due to cough. This trial did not include a head-to-head comparison between ARBs and ACEi, and therefore does not address which agent should be preferred as first-line therapy. Only 24% of participants were receiving spironolactone. The combination of ARBs with spironolactone, may increase the risk of adverse events, particularly hyperkalemia and kidney injury.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter BJ Miller, a hospice and palliative care physician, and Bridget Sumser, a licensed social worker specializing in serious illness and end-of-life care, join Peter to share insights from their decades of work supporting people at the end of life. In this episode, they explore the emotional and physiological processes of dying, the cultural barriers that prevent meaningful conversations about death, and how early engagement with mortality can lead to greater clarity and connection. The conversation highlights the distinctions between hospice and palliative care, the nature of suffering beyond physical pain, and the transformative role of honesty, forgiveness, and relational awareness in the dying process. Through stories and reflections, BJ and Bridget reveal what truly matters in the end—and how the dying can teach the living not only how to face death but how to live more fully. We discuss: The personal journeys of BJ and Bridget into end-of-life care, and the connection between living and dying [3:30]; What dying looks like: the physical, cognitive, and emotional realities at the end of life [13:15]; How historical perspectives on death contrast with modern experiences of dying [25:30]; The difference between palliative care and hospice care [30:45]; The systemic challenges surrounding hospice care: why patients often enter it too late to receive its full benefits [35:30]; How delayed hospice referrals and unspoken preferences often prevent patients from dying where and how they truly want [39:30]; The realities of home hospice: challenges, costs, and burdens placed of families [43:45]; How proactively engaging with the reality of death can avoid unnecessary suffering and promote a more peaceful ending [53:30]; How palliative care is misunderstood and underutilized—especially in cancer care [1:02:45]; Palliative care in the case of Alzheimer's disease: emotional support, future planning, and family involvement [1:12:15]; The importance of having an advance directive: defining what matters most before it's too late [1:23:00]; The differences between how young and old individuals experience dying from cancer [1:30:15]; The difference between pain and suffering, role of medicine in pain relief, and why emotional healing is essential at the end of life [1:35:45]; Dying well: the power of self-honesty and human connection at the end of life [1:47:00]; How psychedelics like psilocybin can unlock emotional breakthroughs and deepen connection for patients near the end of life [1:55:15]; Lessons from the dying on how to live well [1:57:30]; The physical process of active dying, and the emotional and practical considerations for loved ones [2:09:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this debut episode of JACC This Week with Editor-in-Chief Dr. Harlan Krumholz, we explore groundbreaking studies and timely insights from the July 1st issue. Highlights include the impact of wildfire smoke on heart failure risk, new hemodynamic data on mechanical circulatory support in cardiogenic shock, and sobering cardiovascular mortality trends over the past 25 years. Plus, updates on aspirin use, cognitive impairment in CVD, ACC/AHA performance measures, and a leadership reflection from ACC President Dr. Christopher Kramer.

Mortality is often viewed as a key indicator of the quality of care in a healthcare organization, and something that most organizations are working to improve upon. Through Vizient's work with national organizations all working to improve mortality, key lessons learned have emerged that can help organizations improve mortality within their facilities. Shannon Hale Senior PI Director of Performance Improvement Programs at Vizient joins host Nicole Spatafora, AVP, Performance Improvement, Vizient, to discuss mortality improvement.   Guest: Shannon Hale Senior PI Program Director, Performance Improvement Programs Vizient Host: Nicole Spatafora AVP, Performance Improvement Vizient   Show Notes: [00:47 – 02:48] Why it is so important that healthcare facilities look at mortality [02:49 – 04:24] Getting C-Suite buy in [04:25 – 07:36] How organizations can get their frontline engaged [07:37 – 08:58] What happens if you don't have engagement at the C-suite level or frontline level [08:59 – 10:55] Sustaining change [10:56 – 12:15] PI Mortality future plans   Links | Resources: Contacting Knowledge on the Go: picollaboratives@vizientinc.com   Subscribe Today! Apple Podcasts Spotify Android RSS Feed

In this high-impact episode of The Self Aware Leader, host Jason Rigby sits down with elite executive coach Max Stephens—trusted advisor to top CEOs, pro athletes, and Hollywood creators. Max dismantles the myths behind traditional success and shares how high performers can finally find real fulfillment. Whether you're a founder, corporate leader, or entrepreneur on the edge of burnout, Max's Contribution Alignment Model and radical truth-telling will help you stop chasing the wrong goals—and build a life of purpose, peace, and leadership impact. What You'll Learn: Why success without inner healing is a trap The hidden cost of ambition no one talks about Why most leadership coaching fails—and how to fix it How to realign your leadership around purpose, not pressure Max's 3-part framework: Forgiveness, Mortality, Radical Honesty Guest Bio: Max Stephens is a world-class performance coach and author of What the Fck Do You Actually Want?*. With over 1,500 sessions per year and clients across C-suite, sports, and film, Max helps leaders eliminate emotional blind spots and live with unshakable clarity. Episode Highlights: [00:00] Why high performers feel empty at the top [08:00] The neuroscience of contribution vs. isolation [13:00] Max's truth bomb: You're not doing it “for your family” [24:00] The Purpose Framework: Forgiveness, Mortality, Honesty [36:00] Coaching culture is broken—here's what works [45:00] How to reset your leadership thermostat Subscribe for more on: Leadership development Executive coaching Emotional intelligence Strategic thinking Purposeful performance Resources Mentioned:

Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief, and Preeti Malani, MD, MSJ, Deputy Editor of JAMA, the Journal of the American Medical Association, for articles published from June 14-20, 2025.

This episode originally aired on March 23rd, 2023. Dr. Michael Lanspa chats with Dr. Yahya Shehabi about his article, "Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)."

Today's guest is Nicole Nodal-Rogriguez, MSN, RN, CCDS, CDI education specialist at HCPro/ACDIS. Today's show is part of the “Talking CDI” series, hosted by ACDIS Director Rebecca Hendren. Our intro and outro music for the ACDIS Podcast is “medianoche” by Dee Yan-Kay and our ad music is “Take Me Higher” by Jahzzar, both obtained from the Free Music Archive. Have questions about today's show or ideas for a future episode? Contact the ACDIS team at info@acdis.org. Want to submit a question for a future "listener questions" episode? Fill out this brief form!  CEU info: Each ACDIS Podcast episode now offers 0.5 ACDIS CEU which can be used toward recertifying your CCDS or CCDS-O credential for those who listen to the show in the first two days from the time of publication. To receive your 0.5 CEU, go to the show page on acdis.org, by clicking on the “ACDIS Podcast” link located under the “Free Resources” tab. To take the evaluation, click the most recent episode from the list on the podcast homepage, view the podcast recording at the bottom of that show page, and click the live link at the very end after the music has ended. Your certificate will be automatically emailed to you upon submitting the brief evaluation. (Note: If you are listening via a podcast app, click this link to go directly to the show page on acdis.org: https://acdis.org/acdis-podcast/listener-questions-queries-coding-shortages-ai-mortality-reviews) Note: To ensure your certificate reaches you and does not get trapped in your organization's spam filters, please use a personal email address when completing the CEU evaluation form. The cut-off for today's episode CEU is Friday, June 20, 2025, at 11:00 p.m. Eastern. After that point, the CEU period will close, and you will not be eligible for the 0.5 CEU for this week's episode. Today's sponsor: Today's show is brought to you by ACDIS Encore: Clinical & Coding Online, a special virtual event featuring sessions recorded live during the 2025 ADCIS conference—the entire Clinical & Coding track, happening August 12-14, 2025. Learn more and register here: https://bit.ly/3SKItN6 ACDIS update: Respond to the 2025 CDI Week Industry Survey by July 18! (https://www.surveymonkey.com/r/2025-CDI-Week-Industry-Survey) Apply for one of ACDIS' committees by June 30! (https://www.surveymonkey.com/r/June-2025-ACDIS-committees) Apply to speak at one of ACDIS' 2026 events, including the 2026 ACDIS Conference, by July 21! (https://bit.ly/4jLYDkr)

Gratitude, in Hebrew, is a fabulous and mysterious word, implying so much more than just "thanks."

Support the show

Welcome back to the Longevity Podcast! In this episode, I have the pleasure of sitting down with James Strole, a beacon in the radical longevity space and the visionary founder behind People Unlimited and RAADfest. James shares the personal journey that led him into the world of life extension—shaped by a spiritually open-minded mother, a pivotal loss, and a lifelong desire to challenge the idea that aging is inevitable. Get 10% off your tickets to RAADfest using code: "niddam"   What we discuss: James Strole's personal journey to radical longevity ... 00:04:00 Spiritual roots and early inspiration ... 00:10:00 Transition from spiritual to scientific approaches ... 00:13:00 Launching RAADfest and the shift toward hard science ... 00:16:00 Evolution of the longevity movement over the decade ... 00:21:00 Access to longevity innovations and RAAD Clinics ... 00:22:00 Most exciting developments: gene therapy and age reversal ... 00:24:00 Daily longevity pillars: diet, movement, mindset ... 00:26:00 Mindset and embracing the possibility of immortality ... 00:35:00 Overcoming skepticism and “against nature” arguments ... 00:41:00 Societal implications of extreme longevity ... 00:44:00 Are we at the tipping point? The “era of immortality” ... 00:47:00 Advice for newcomers: join the conversation and community ... 00:50:00   Our Amazing Sponsors: NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. Mitoblue by Wizard Sciences - Everything in the formula is there to help you think clearer, move better, and stay resilient—mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase. Mimio: A supplement that gives you all the cellular, metabolic, and longevity benefits of a prolonged fast—even on the days when you're eating normally. Visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Die Themen in den Wissensnachrichten: +++ Regelmäßiges Gehen beugt chronischen Rückenschmerzen vor +++ Zahl der Aasfresser sinkt und das ist ein Problem +++ Menschen verwerten Kalorien unterschiedlich +++**********Weiterführende Quellen zu dieser Folge:Volume and Intensity of Walking and Risk of Chronic Low Back Pain, Jama Network Open, 13.06.2025Global decline of apex scavengers threatens human health, PNAS, 16.06.2025Tree ring isotopes reveal an intensification of the hydrological cycle in the Amazon, Communications Earth and Environment, 17.06.2025Methanogenesis associated with altered microbial production of short-chain fatty acids and human-host metabolizable energy, The ISME Journal, 22.05.2025Coffee Consumption and Mortality among United States Adults: A Prospective Cohort Study, The Journal of Nutrition, 12.05.2025Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

Our party meets up with their case worker before finding themselves against the strongest of potion cellars!Come join us on Discord:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://discord.gg/ntaEjvc⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us on Patreon!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/IndoorAdventures⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Merch:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠indooradventure.red⁠⁠⁠bubble.com

Hello again, my dear.I was hoping you'd come back.We've saved you a seat—right by the fire… or is it a furnace?Tonight, I've brought you four tales. Strange ones. Sad ones. A little dangerous, even.But you like that, don't you?

Chad Myers and I talk about the latest piece from The Embassy - The Good People and The Bad People.Here is an excerpt:About four or five years ago, a friend gave me a copy of Richard Beck's book Unclean: Meditations on Purity, Hospitality, and Mortality. In this book, Beck explores how we view concepts like purity and contamination in our culture (and other cultures) and how that transfers to our view of people. Often, the people we tend to reject are those who move us to disgust. Our rejection of them is partly a reflection of that disgust. Beck asks us to imagine a glass of juice into which he drops a cockroach and stirs it around. After removing the bug, do we want the juice? Almost everyone would say no. But Beck, citing the work of Psychologists Paul Rozin and April Fallon, shares that after the juice is filtered in a way that ensures all traces of the cockroach have been removed - even if the juice is boiled after filtering - most people refuse to drink the juice. It has been contaminated for us, it has failed the purity test in a way that is permanent. It is an example of a kind of fear of contamination that comes from a reaction of disgust. Disgust and fear can be related - we fear coming into contact with what disgusts us. It is also an example of what is called negativity dominance. A small amount of the negative dominates and contaminates the larger amount. It doesn't matter if it is a 12 ounce glass of juice or a gallon, or if it is a small or a large bug, the result is the same. The clean juice doesn't counteract the bug, instead, it is contaminated in its entirety.As I said, I read Beck's book about four or five years ago but pulled it off my shelf to take another look after receiving a text from another friend. He sent me a link to an interview of comedian Tim Dillon by CNN's Elle Reeve. In his text, he described as the hour and ten minute long interview as “one of the more painful interviews I've ever witnessed.” Of course I watched the whole thing. Painful is not a bad description, I thought it had a bit of a train-wreck quality. Maybe I shouldn't have, but I found it fascinating.Dillon is a successful and popular comedian with a successful and popular podcast. He is a bit hard to pin down. I think that is a good thing, more of us should be a bit hard to pin down. I'll come back to that. Dillon is gay, irreverent, irreligious (I believe), a liberal of sorts politically, but heterodox, eclectic in his thinking. As such, he has been critical of positions taken by the right and the left, politically and culturally. He has been critical of positions I hold. I forgive him this indiscretion because he is very funny.I know nothing about Reeve aside from this interview. On the other hand, the interview was an hour and ten minutes long and I watched all of it. In my reading, Reeve represented a stance that is all too familiar in our culture - and I don't just mean it is reflected in the media, though it is prominent there. It seems to be an assumption underlying many of our interactions, social media or conversations or whatever, regarding any number of topics related to the culture and politics.Reeve's assumption, underlying far more than half of her questions, is that there are good people and bad people. She repeatedly asked Dillon about trends in comedy, in the podcast universe, in politics that had a very similar theme. There are good people and bad people, Reeve clearly assumed herself to be one of the good people, and assumed it is the job of the good people - be they comedians, podcasters, journalists, or politicians, to expose the bad people as bad. She never attempted to make the case for this assumption, she never argued for it, it was, to her, unquestioned. This assumption manifested itself in many ways, but most prominently, Reeve considered some of Dillon's podcast guests to be bad and wanted Dillon to do more to expose their badness. She also seemed to bemoan the reality of podcasters in general talking to politicians without asking them “are you bad?”I don't have an opinion about the podcasts that she asked about - I haven't heard any of them. But I think this good people / bad people assumption is behind much of our cultural division and, quite frankly, makes us dumber. As Dillon was pushing back on her assumption, Reeve said, “these are not my ‘are you bad?' questions”, to which Dillon replied, “we are all bad.” Reeve then attempted to make a soft case that Dillon was bad, in a ‘if I was going to make the case, it would look like this' sort of way. I think she thought, and wanted it to be clear to us, that she thought Dillon was one of the bad people (and she was doing her good people duty by pointing it out).Dillon's response that we are all bad, though probably he is not aware of it, has a grounding in Christian theology. We are all flawed, we are all broken, we all need redemption. We should not sit in judgment, certainly not in condemnation, of others.The good people / bad people assumption (again, it is not argued for, it is simply assumed) generally means that I assume the good people position. I am joined by the people who are “like me”, the other “good people.” I or we are in a position to judge, to condemn, the badness of others. But I don't need to be too self-critical. I am one of the good people.I'm not naive, I am aware that some people seem to do a higher percentage of bad things than others. However, the proposition that my own percentage is 0 or so low that it has no real effect in the world is worse than naive. Moreover, even people who allegedly fit into the bad category may be right in this or that particular case, they may say something true that I should hear. Which I won't if I make it the hallmark of the good person never to listen to the bad people. Which I also won't if I think any contact with the bad people contaminates me permanently. I must stay away, I must not platform, I must condemn - in order to maintain my purity as one of the good people. After all, the smallest exposure to the impurity of the bad people threatens to contaminate me entirely.One of the results of this assumption, painfully obvious in the interview, is a lack of genuine curiosity about other people - especially if we have already classified them as good or bad. Reeve lacked curiosity about what Dillon would say in response to her and, therefore, seemed to miss much of what he was saying. Or she didn't interact with it, choosing instead to pursue the good/bad dichotomy. As I said, Dillon is a bit hard to pin down, a bit of a contradiction or mystery that I find interesting, but that is lost on Reeve, or on anyone else who is only interested in the moral classification. When we put ourselves in this position, we stop listening, we stop being challenged, we stop refining our own thinking. We are far poorer for it and so is our culture. Just to be clear, I find myself agreeing with Dillon sometimes and disagreeing with him maybe a bit more of the time. But if I allow myself to listen, I get to know something about someone else, I learn something about what they think, and, with Dillon, I often laugh.Check out the whole piece. Get full access to The Embassy at theembassy.substack.com/subscribe

Mortality gets a little bit closer for the baby boomer generation. Learn more about your ad choices. Visit megaphone.fm/adchoices

Send us a textWelcome back Rounds Table Listeners! Today we're introducing a new format—the first episode in our Trial Files series, where we provide an overview of a recent Trial Files issue. This week, Dr. Mike Fralick discusses three trials included in a recent throwback issue: opioids versus non-opioids for chronic pain; IV albumin for renal impairment and mortality; and omeprazole before endoscopy in patients with GI bleed. Three trials, 9 minutes, here we go!1. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Trial (00:00 - 2:46)2. Effect of Intravenous Albumin on Renal Impairment and Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis (2:47 - 4:50)3. Omeprazole before Endoscopy in Patients with Gastrointestinal Bleeding (4:51 - 7:39)What is Trial Files?A free monthly newsletter on practice-changing trials, delivered straight to your inbox-- sign up here! (7:40 - 8:40)Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

In this thought-provoking episode of Deprogrammed, Catherine welcomes longtime friend, yogi, and esoteric researcher Brice Watson to unpack the layers of programming that shape our views on health, history, identity, and truth.From ghost stories in the Deep South to sacred Sanskrit teachings in India, Brice shares her journey of awakening, spiritual sovereignty, and how she came to question everything she was taught—from religion to medicine, education to politics.We explore:- Why "deprogramming" means letting go of your identity- The dangers of waiting for someone else to save you- How yoga philosophy and law of one teachings point us toward personal sovereignty- What spiritual ego looks like in the truth movement- How physical movement can reconnect us to truthThis is not just a conversation—it's a roadmap for waking up.

SummaryIn this episode of the Gird Up Podcast, Charlie Ungemach and Jacob Klug explore themes of manhood through the lens of poetry, particularly focusing on Rudyard Kipling's poem 'If.' They discuss the challenges of criticism, the nature of risk and resilience, and the philosophical implications of triumph and disaster. The conversation emphasizes the importance of self-reflection, humility, and the understanding that both success and failure are temporary states. Ultimately, they highlight the need for a grounded perspective in life, rooted in faith and the recognition of one's limitations. In this conversation, Jacob and Charlie explore the themes of life's challenges, the importance of perspective, and the value of hard work. They discuss the balance between physical and mental challenges, the significance of purpose in actions, and the role of recreation and entertainment in life. The conversation also delves into the importance of physical labor, reflections on mortality, and the essence of true manhood, emphasizing love and vulnerability as central to human experience.Chapters00:00 Introduction and Support for Girt Up Podcast03:49 Exploring Manhood Through Poetry10:21 Kipling's 'If': A Deep Dive into Manhood20:01 The Challenges of Criticism and Self-Reflection29:45 Building Back After Loss: Resilience and Action30:42 Understanding Job's Trials and Divine Sovereignty33:50 The Nature of Risk and Stewardship37:40 Embracing Risk in Christian Life41:23 The Value of Hard Work and Mastery45:46 Perspective on Triumph and Disaster50:00 The Importance of Doing Hard Things54:06 Purpose Behind Hard Work and Discipline59:51 The Value of Love and Redemption01:00:32 Recreation and Entertainment: A Necessary Balance01:02:45 The Role of Physical Labor in Our Lives01:08:36 The Importance of Meaningful Rest01:11:07 Mortality and the Human Experience01:17:46 The Limitations of Stoicism01:22:32 The Centrality of Love in Virtue01:28:22 Faith and the Journey to WholenessJacob's Links:https://x.com/i/flow/login?redirect_after_login=%2Fklugsayshttps://www.youtube.com/ @RevKlug Gird Up Links:https://youtube.com/@girdupministries4911?si=tbCa0SOiluVl8UFxhttps://www.instagram.com/girdup_be_a_man/https://www.girdupministries.com Hosted on Acast. See acast.com/privacy for more information.

THE LANCET 2003;362:767-771Background: Angiotensin II which plays a role in ventricular remodeling and progression of heart failure can be produced by pathways independent of angiotensin convening enzyme. Preliminary studies showed that the combination of angiotensin II blockers with angiotensin-converting enzyme inhibitors (ACEi) improves hemodynamics and reduces ventricular remodeling.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Added trial sough to assess if adding the angiotensin-receptor blocker (ARB), candesartan, to ACEi could improve outcomes in patients with systolic heart failure.Patients: Eligible patients had left ventricular ejection fraction of 40% or less within the previous 6 months, and NYHA class II, III or IV symptoms. Patients with NYHA class II symptoms had to have cardiac-related hospitalization within 6 months. Patients also had to have treatment with ACEi at a constant dose for at least 30 days.Exclusion criteria were not provided in the main manuscript.Baseline characteristics: Patients were recruited from 618 centers in 26 countries. The trial randomized 2,548 patients – 1,276 randomized to receive candesartan and 1,272 to receive placebo.The average age of patients was 64 years and 79% were men. The average left ventricular ejection fraction was 28%. Cardiomyopathy was ischemic in 62% of the patients. The NYHA class was II in 24% of the patients, III in 73% and IV in 3%.Approximately 48% had hypertension, 30% had diabetes, 56% had prior myocardial infarction, 9% had stroke, 27% had atrial fibrillation and 17% were current smokers.At the time of enrollment, 90% were taking a diuretic, 58% were taking digoxin, 55% were taking beta-blockers, 17% were taking spironolactone and all but two patients were taking ACEi.Procedures: The trial was double-blinded. Patients were assigned in a 1:1 ratio to receive candesartan starting at 4 or 8mg once daily or placebo. The treatment was doubled every two weeks to a target dose of 32mg once daily.After randomization, follow up occurred at 2, 4, and 6 weeks, 6 months and every 4 months thereafter.Endpoints: The primary outcome was a composite of cardiovascular death or heart failure hospitalizations. All deaths were classified as cardiovascular unless there was a clear non-cardiac cause.Analysis was performed based on the intention-to-treat principle. The estimated sample size to have 80% power at 5% alpha was 2,300 patients. The sample size calculation assumed 16% relative risk reduction in the primary outcome with candesartan assuming an 18% annual event rate in the placebo arm.Results: The median follow up time was 41 months. The mean candesartan daily dose was 24mg at 6 months.Candesartan reduced the primary endpoint of cardiovascular death or heart failure hospitalizations (37.9% vs 42.3%, adjusted HR: 0.85, 95% CI: 0.75 – 0.96; p= 0.01). Candesartan reduced the individual components of the primary outcome - (23.7% vs 27.3%; p= 0.021) for cardiovascular death and (24.2% vs 28.0%; p= 0.018) for heart failure hospitalizations. There was no significant reduction in all-cause death (29.5% with candesartan vs 32.4%; p= 0.105). The number of patients who had any hospitalization was similar in both groups (66.8% with candesartan vs 67.5%; p= 0.7), however, the total number of hospitalizations was lower with candesartan (2,462 vs 2,798; p= 0.023).Serum creatinine at least doubled in 7% of the patients in the candesartan group vs 6% in the placebo group. In the subset of patients taking spironolactone, serum creatinine at least double in 11% of the patients taking candesartan compared to 4% of the patients taking placebo.Hyperkalemia, defined as serum potassium of 6 mmol/L or higher, occurred in 3% of the patients in the candesartan group vs 1% in the placebo group. In the subset of patients taking spironolactone, hyperkalemia occurred in 4% of the patients taking candesartan compared to 1% of the patients taking placebo.There were two cases of angioedema in the candesartan group and three in the placebo group. All patients were taking an ACEi.There were no significant subgroup interactions, including in patients taking both beta-blockers and ACEi at baseline.Conclusion: In patients with systolic heart failure, adding candesartan to an ACEi reduced the primary composite outcome of cardiovascular death or heart failure hospitalizations with a number needed to treat of approximately of 23 patients over 41 months of follow up. The total number of all-cause hospitalizations was reduced by 336 with candesartan. All-cause death was not significantly reduced with candesartan.While the results of the trial appear impressive, the high number of adverse outcomes with candesartan in patients taking spironolactone is concerning. Spironolactone led to significant reduction in all-cause mortality in patients with systolic heart failure, as seen in the RALES trial, and should be prioritized over adding candesartan. Notably, fewer than 20% of patients in the trial were on spironolactone at baseline; if more had been, the incremental benefit of candesartan would likely have been reduced due to an increased risk of adverse effects from triple neurohormonal blockade (ACEi, ARBs, and mineralocorticoid receptor antagonists). Furthermore, spironolactone acts by blocking the aldosterone receptor, which is downstream in the renin–angiotensin–aldosterone system. Since candesartan blocks angiotensin II upstream in the same pathway, simultaneous inhibition at multiple points may lead to diminishing benefit.Finally, the differences observed in the subgroup of patients on beta-blockers between this trial and Val-HeFT remain unclear and may simply reflect the play of chance. As we previously discussed, patients receiving both an ACEi and beta-blockers had worse outcomes with valsartan in the Val-HeFT trial.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

BYU-Idaho Student Honor Administrator Casey Puzey emphasizes the importance of enduring trials in mortality. He says the hardships people endure now will help them become the individuals God needs them to be. Article: https://www.byui.edu/radio/campus-news/byu-idaho-student-honor-administrator-emphasizes-the-importance-of-enduring-trials-in-mortality

14th ACC 2025: SBP < 130 mmHg Linked to Reduced CV Mortality in Adults +80 Y

The grave is meant to be the end… but often it's only the beginning.Four eerie stories rise from beneath the soil to haunt the living, revealing secrets that refuse to stay buried. These tales explore not just death—but what waits beyond.

SummaryIn this engaging conversation, Nick Lavery shares his experiences as a military service member, discussing the importance of gratitude, the realities of life outside the U.S., and the human connections formed in combat zones. He emphasizes the significance of trust within teams, the challenges of media representations of military life, and the lessons learned that can be applied to civilian life. Nick also reflects on confronting mortality, the journey back to active duty after injury, and the personal growth from these experiences. In this conversation, Nick Lavery shares his journey of overcoming challenges and redefining success through accountability, integrity, and mentorship. He discusses the importance of trust within teams, the military assessment process, and how he teaches his children about accountability. Nick also reflects on his transition from military service to a new purpose in life, emphasizing the value of hard work and the lessons learned from writing his book. The discussion culminates in deeply exploring success, highlighting the significance of accomplishment, fulfillment, and maintaining integrity throughout one's journey. Takeaways- Saying thank you for service is appreciated, but living life fully is the best gratitude.- Experiencing life outside the U.S. provides perspective on freedoms and opportunities.- Human connections, especially with children, reveal commonalities across cultures.- Media often dramatizes military life, but some portrayals are more accurate than others.- Trustworthiness is crucial in high-stakes environments, often more than skill.- Feedback is essential for growth and should be embraced as a gift.- Life is finite, and this realization can lead to deeper humility and purpose.- The journey back to active duty requires resilience and determination.- Trust must be established from the beginning in leadership roles.- Personal growth often comes from confronting one's own mortality.  Managing expectations is crucial in facing challenges.- Trust is built through consistent actions and results.- Celebrating small wins is important for motivation.- Accountability is a rare but valuable trait.- Teaching children about consequences is essential for their growth.- Finding purpose after military service can be fulfilling.- Writing can be a powerful tool for self-discovery.- Success is defined by accomplishment, fulfillment, and integrity.- Integrity makes the journey worthwhile, even if it's harder.- Leading by example is key in parenting and mentorship. Chapters 00:00 Introduction and Gratitude for Service02:56 Experiencing Life Outside the U.S.06:10 Human Connections in Combat Zones09:08 Media Representations of Military Life11:54 The Importance of Trust in Teams14:57 Lessons from Military to Civilian Life17:57 Confronting Mortality and Humility20:52 The Journey Back to Active Duty31:41 Facing Expectations and Building Trust34:24 The Journey of Assessment and Acceptance39:49 Celebrating Wins and Preparing for New Challenges40:17 Accountability and Integrity in Society45:02 Teaching Accountability to the Next Generation51:08 Finding Purpose After Military Service53:14 The Writing Journey and Self-Discovery59:45 Defining Success: Accomplishment, Fulfillment, and Integrity      

Are things getting better or worse? What if your a career in medicine, the collapse of civilization, and the maternal mortality crisis all shared one uncomfortable truth–progress doesn't guarantee clarity, balance, or justice? In this episode, M3 Zay Edgren confesses he's feeling a bit doomy about humanity's chances, and M2 Taryn O'Brian feels frustrated with medicine's successes with acute care while primary care languishes. But M3 Jeff Goddard (and Dave) are more optimistic, at least on the grand scale. What every future healthcare worker needs to ask is, “What does helping actually mean when the system is stacked with trade-offs? You'll get insight into how real medical students think through messy, high-stakes issues—like why we're amazing at keeping preemies alive but failing mothers, or why primary care is where the real impact happens but nobody wants to do it. We explore what career indecision really looks like when you're smart, driven, and yet unsure. You'll also hear honest takes on burnout, idealism, and what med students actually think about the world they're about to inherit—and remake. If you're staring down the med school track wondering what's waiting for you on the other side, this episode hands you the context no class will. You'll leave smarter, more grounded—and possibly nervous, but in a productive way.

Crystal Yang talks about her research on the accreditation of jail-based health care. “The Hidden Health Care Crisis Behind Bars: A Randomized Trial to Accredit U.S. Jails” by Marcella Alsan and Crystal Yang. OTHER RESEARCH WE DISCUSS IN THIS EPISODE: “Impact of hospital accreditation on quality improvement in healthcare: A systematic review” by Mohammad J. Alhawajreh, Audrey S. Paterson, and William J. Jackson. “Improvement in quality of hospital care during accreditation: A nationwide stepped-wedge study" by Søren Bie Bogh, Anne Mette Falstie-Jensen, Erik Hollnagel, René Holst, Jeffrey Braithwaite, and Søren Paaske Johnsen. “Evaluating Accreditation” by Charles D. Shaw. "Mental Health and Criminal Involvement: Evidence from Losing Medicaid Eligibility" by Elisa Jácome. Probable Causation Episode 60: Elisa Jácome. "In-Kind Welfare Benefits and Reincarceration Risk: Evidence from Medicaid" by Marguerite Burns and Laura Dague. Probable Causation Episode 103: Marguerite Burns and Laura Dague. "Access to health Care and Criminal Behavior: Evidence form the ACA Medicaid Expansions" by Jacob Vogler. "The Effect of Medicaid Expansion on Crime Reduction: Evidence from HIFA-Waiver Expansions" by Hefei Wen, Jason M. Hockenberry, and Janet R. Cummings. “The Health Effects of Prison” by Randi Hjalmarsson and Matthew J. Lindquist. Probable Causation Episode 41: Matthew Lindquist. “The Effect of Incarceration on Mortality" by Samuel Norris, Matthew Pecenco, and Jeffrey Weaver.

In the fifth episode of the Society of Actuaries Research Institute's special podcast series on the Long-Term Drivers of Future Mortality, host Kara Clark, Senior Practice Research Actuary, is joined by Al Klein, Principal and Consulting Actuary at Milliman and co-author of the featured report, and Erik Pickett, Actuary and Chief Content Officer at Club Vita. This episode explores diseases as critical drivers of future mortality. Topics include chronic conditions like cardiovascular disease, diabetes, and cancer; mental health and neurodegenerative diseases; and the ongoing threats of infectious diseases and pandemics. The speakers highlight how evolving medical treatments, shifting demographics, and public health infrastructure influence mortality projections—and the implications these have for actuaries. This conversation is grounded in Chapter Five: Diseases from the report, Long-Term Drivers of Future Mortality, originally presented at the 2023 Living to 100 Symposium.

Friday Night Live 23 May 2025In this episode, I explore philosophical themes surrounding mortality, societal violence, and personal experiences. Reflecting on Scott Adams' health challenges, I critique the criminalization of self-defense and the impact of societal labels on violence. I share parenting anecdotes that highlight inattentiveness and its consequences, while discussing the complexities of modern child-rearing.Through humor, I balance personal ambitions with parenting challenges and examine love, self-worth, and the dangers of vanity. I advocate for empathy and humility in relationships, emphasizing the importance of mutual respect and emotional honesty to foster meaningful connections.GET MY NEW BOOK 'PEACEFUL PARENTING', THE INTERACTIVE PEACEFUL PARENTING AI, AND THE FULL AUDIOBOOK!https://peacefulparenting.com/Join the PREMIUM philosophy community on the web for free!Subscribers get 12 HOURS on the "Truth About the French Revolution," multiple interactive multi-lingual philosophy AIs trained on thousands of hours of my material - as well as AIs for Real-Time Relationships, Bitcoin, Peaceful Parenting, and Call-In Shows!You also receive private livestreams, HUNDREDS of exclusive premium shows, early release podcasts, the 22 Part History of Philosophers series and much more!See you soon!https://freedomain.locals.com/support/promo/UPB2025

On this week's episode of Inklings we go over the talk by Dallin H. Oaks: Divine Helps for Mortality.

Enjoy some of our favorite recent conversations from the centennial series:Mark Mather, demographer and associate vice president for U.S. Programs at the Population Reference Bureau (PRB) walks us through the shifts over the past 100 years in U.S. birth rates, followed by changes in U.S. mortality statistics.Julie Suk, a law professor at Fordham University and the author of We the Women: The Unstoppable Mothers of the Equal Rights Amendment (Skyhorse Publishing, 2020), reviews the history of the Equal Rights Amendment, from its introduction by Alice Paul in 1923 through its current disputed status, following passage by a 38th state and President Biden's declaration that it's the "law of the land."Liza Donnelly, writer and cartoonist at The New Yorker and the author of Very Funny Ladies: The New Yorker's Women Cartoonists, 1925-2021 (Prometheus, 2022) and the substack "Seeing Things", talks about the evolution of the "New Yorker cartoon" over the magazine's 100-year history.Co-hosts of The Season Pass podcast, Robert Coker, author of the book Roller Coasters: A Thrill Seeker's Guide To The Ultimate Scream Machines (Main Street, 2002) and Douglas Barnes, talk about the history of roller coasters, from the "Golden Age" of 1920's wooden coasters like Coney Island's Cyclone through modern steel "stratacoasters," like the late lamented Kingda Ka, which was recently imploded to make room for something even bigger. These interviews were lightly edited for time and clarity; the original web versions are available here:100 Years of 100 Things: US Population Shifts (Jan 2, 2025)100 Years of 100 Things: US Mortality Causes (Jan 6, 2025)100 Years of 100 Things: The ERA (Mar 4, 2025)100 Years of 100 Things: New Yorker Cartoons (Mar 20, 2025)100 Years of 100 Things: Roller Coasters (Apr 11, 2025)

*Content warning: birth trauma, medical trauma, medical neglect, racism, death of an infant, infant loss, death, maternal loss, mature and stressful themes.*Free + Confidential Resources + Safety Tips: somethingwaswrong.com/resources Center for Black Maternal Health & Reproductive Justice:https://blackmaternalhealth.tufts.edu/Center for Black Maternal Health & Reproductive Justice Instagram:https://www.instagram.com/cbmhrj_tufts/Center for Black Maternal Health & Reproductive Justice Facebook:https://www.facebook.com/CBMHRJTufts/Center for Black Maternal Health & Reproductive Justice LinkedIn:https://www.linkedin.com/company/cbmhrjtufts/Sources: Addressing Transportation Barriers to Improve Healthcare Access in Arizonahttps://repository.arizona.edu/handle/10150/674794 Advancing Health Equity and Value-Based Care: A Mobile Approachhttps://info.primarycare.hms.harvard.edu/perspectives/articles/mobile-clinics-in-the-us-health-system#:~:text=Mobileclinicsareaproven,thecriticalweeksafterbirth American College of Nurse Midwiveshttps://midwife.org/ American College of Obstetricians and Gynecologists (ACOG)https://www.acog.org/ Birth Centers in Massachusettshttps://baystatebirth.org/birth-centers A Brief History of Midwifery in Americahttps://www.ohsu.edu/womens-health/brief-history-midwifery-america Clinical outcomes improve when patient's and surgeon's ethnicity match, study showshttps://www.uclahealth.org/news/article/clinical-outcomes-patients-surgeons-concordanceThe Controversial Birth of American Gynecologyhttps://researchblog.duke.edu/2023/10/27/the-controversial-birth-of-american-gynecology/ 'Father Of Gynecology,' Who Experimented On Slaves, No Longer On Pedestal In NYChttps://www.npr.org/sections/thetwo-way/2018/04/17/603163394/-father-of-gynecology-who-experimented-on-slaves-no-longer-on-pedestal-in-nyc Governor Healey Signs Maternal Health Bill, Expanding Access to Midwifery, Birth Centers and Doulas in Massachusettshttps://www.mass.gov/news/governor-healey-signs-maternal-health-bill-expanding-access-to-midwifery-birth-centers-and-doulas-in-massachusetts#:~:text=GovernorHealeySignsMaternalHealthBillCExpanding,ExecutiveOfficeofHealthandHumanServices Governor Murphy Signs Bill Establishing Maternal and Infant Health Innovation Centerhttps://www.nj.gov/governor/news/news/562023/approved/20230717a.shtml Helping Mothers and Children Thrive: Rethinking CMS's Transforming Maternal Health (TMaH) Modelhttps://www.milbank.org/quarterly/opinions/helping-mothers-and-children-thrive-rethinking-cmss-transforming-maternal-health-tmah-model/#:~:text=TheTransformingMaternalHealth(TMaH)Model&text=TheTMaHModelfocuseson,midwiferyservicesanddoulacare The Historical Significance of Doulas and Midwiveshttps://nmaahc.si.edu/explore/stories/historical-significance-doulas-and-midwivesInfant Health and Mortality and Black/African Americanhttps://minorityhealth.hhs.gov/infant-health-and-mortality-and-blackafrican-americans#:~:text=In2022%2Ctheinfantmortality,Figure2 Legislature Passes Comprehensive Maternal Health Billhttps://malegislature.gov/PressRoom/Detail?pressReleaseId=136Life Story: Anarcha, Betsy, and Lucyhttps://wams.nyhistory.org/a-nation-divided/antebellum/anarcha-betsy-lucy/Management of Postpartum Hemorrhage in Low- and Middle-Income Countries: Emergency Need for Updated Approach Due to Specific Circumstances, Resources, and Availabilitieshttps://pmc.ncbi.nlm.nih.gov/articles/PMC11643001/#:~:text=EtiologyandRiskFactorsof,insufficienttreatment%E2%80%9D%5B50%5D March of Dimeshttps://www.marchofdimes.org/peristats/about-us Maternity Care Deserthttps://www.marchofdimes.org/peristats/data?top=23 Maternal deaths and mortality rates by state, 2018-2022https://www.cdc.gov/nchs/maternal-mortality/mmr-2018-2022-state-data.pdf Maternal Mortality in the United States After Abortion Banshttps://thegepi.org/maternal-mortality-abortion-bans/#:~:text=In2023%2CTexas'smaternalmortality,suffermaternaldeathin2023 Maternal Mortality in the U.S Declined, though Disparities in the Black Population Persisthttps://policycentermmh.org/maternal-mortality-in-the-u-s-a-declining-trend-with-persistent-racial-disparities-in-the-black-population/Maternal Mortality Is on the Rise: 8 Things To Knowhttps://www.yalemedicine.org/news/maternal-mortality-on-the-rise Maternal Mortality: How the U.S. Compares to Other Rich Countrieshttps://www.usnews.com/news/best-countries/articles/2024-06-04/how-the-u-s-compares-to-other-rich-countries-in-maternal-mortalityMaternal Mortality Rates in the United States, 2021https://www.cdc.gov/nchs/data/hestat/maternal-mortality/2021/maternal-mortality-rates-2021.htm#:~:text=In2021%2C1%2C205womendied,20.1in2019(Table) Medical Exploitation of Black Womenhttps://eji.org/news/history-racial-injustice-medical-exploitation-of-black-women/National Midwifery Institutehttps://www.nationalmidwiferyinstitute.com/midwifery National Counsel of State Boards of Nursinghttps://www.ncsbn.org/North American Registry of Midwives (NARM)https://narm.org/ Outcome of subsequent pregnancies in women with complete uterine rupture: A population-based case–control studyhttps://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/aogs.14338#:~:text=outcomesarerare.-,1INTRODUCTION,experienceacompleteuterinerupture.&text=Completeuterineruptureisdefined,completeruptureofthemyometrium Pregnancy-Related Deaths: Data From Maternal Mortality Review Committees in 36 U.S. States, 2017–2019https://www.cdc.gov/maternal-mortality/php/data-research/mmrc-2017-2019.html Preterm Birthhttps://www.cdc.gov/maternal-infant-health/preterm-birth/index.html#:~:text=Pretermbirthrates&text=In2022%2Cpretermbirthamong,orHispanicwomen(10.1%25) Racial Disparities in Maternal and Infant Health: Current Status and Efforts to Address Themhttps://www.kff.org/racial-equity-and-health-policy/issue-brief/racial-disparities-in-maternal-and-infant-health-current-status-and-efforts-to-address-them/The Racist History of Abortion and Midwifery Banshttps://www.aclu.org/news/racial-justice/the-racist-history-of-abortion-and-midwifery-bans Reducing Disparities in Severe Maternal Morbidity and Mortalityhttps://pmc.ncbi.nlm.nih.gov/articles/PMC5915910/#:~:text=Severemorbidityposesanenormous,ofseverematernalmorbidityevents State investigating Dallas birth center and midwives, following multiple complaints from patientshttps://www.wfaa.com/article/news/local/investigates/state-investigating-dallas-birth-center-midwives-following-multiple-complaints-from-patients/287-ea77eb18-c637-44d4-aaa2-fe8fd7a2fcef The State of Telehealth Before and After the COVID-19 Pandemichttps://pmc.ncbi.nlm.nih.gov/articles/PMC9035352/ Texas Department of Licensing and Regulation (TDLR)https://www.tdlr.texas.gov/ U.S. maternal death rate increasing at an alarming ratehttps://news.northwestern.edu/stories/2024/03/u-s-maternal-death-rate-increasing-at-an-alarming-rate/Which states have the highest maternal mortality rates?https://usafacts.org/articles/which-states-have-the-highest-maternal-mortality-rates/ Why Equitable Access to Vaginal Birth Requires Abolition of Race-Based Medicinehttps://journalofethics.ama-assn.org/article/why-equitable-access-vaginal-birth-requires-abolition-race-based-medicine/2022-03 Zucker School of Medicine, Amos Grunebaum, MDhttps://faculty.medicine.hofstra.edu/13732-amos-grunebaum/publications *SWW S23 Theme Song & Artwork: Thank you so much to Emily Wolfe for covering Glad Rag's original song, U Think U for us this season!Hear more from Emily Wolfe:On SpotifyOn Apple Musichttps://www.emilywolfemusic.com/instagram.com/emilywolfemusicGlad Rags: https://www.gladragsmusic.com/ The S23 cover art is by the Amazing Sara StewartFollow Something Was Wrong:Website: somethingwaswrong.com IG: instagram.com/somethingwaswrongpodcastTikTok: tiktok.com/@somethingwaswrongpodcast Follow Tiffany Reese:Website: tiffanyreese.me IG: instagram.com/lookiebooSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.