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Julie Pelipas and Olya Kuryshchuk discuss the impact of the war in Ukraine and how creativity has endured and been a source of strength amid the destruction.Background: Since the war broke out in Ukraine, creativity has proved to be a source of resilience for Ukrainians. This week on The BoF Podcast, Julie Pelipas, the former fashion director of Vogue Ukraine and founder of Bettter Upcycling System and Olya Kuryshchuk, founder and editor-in-chief of editorial platform 1 Granary share poweful stories of culture, community and human kindness amid the destruction. “We live a double life at the moment,” Kuryshchuk said at BoF VOICES 2022. “We're here in this beautiful place today… but at the same time, literally right now, most of my brothers, our families, our childhood friends, they don't have electricity, water, heating, internet, phone connection.” Key Insights: “[I've] never been more grateful and more excited to work in fashion than since the war started,” says Kuryshschuk. “When so much is taken away from you, you really start cherishing what you have.” Understanding and learning from past mistakes has been critical to helping Ukrainians unite against Russia as they look to build an independent future. “I really believe that we cannot really speak about the future if we are blind to our present,” says Pelipas. Creatives are informing the international community of the plight of the Ukrainian people by utilising human stories of hope. “Power is communication,” says Kuryshschuk. “We need to find how we communicate to make sure that the message reaches people.”Additional Resources:BoF VOICES 2022: Live Your Best Life: In the final session of BoF's annual gathering, speakers from model Dennis Okwera and Coty chief Sue Y. Nabi to Nike's Larry Miller and activist Malala Yousafzai reflected on their personal histories and inner powers.To subscribe to the BoF Podcast, please follow this link. Hosted on Acast. See acast.com/privacy for more information.

Part 2 of yesterday’s conversation with Penney Peirce (episode 168) — listen in as we continue unpacking her essay in conversation together, How Coronavirus is Speeding Us Toward Transparency. In this second half, we talk about the stock market, how money is like a child and responds to our inner energy blueprint, how to find and reconnect with your home frequency, and making the most of business lulls (when ready). Background: Since the pandemic started, I have been wondering what Penney’s take on all this would be. Longtime listeners know she needs no introduction, as people often remark to me that the episodes with her are their favorite! We have 11 conversations in the Penney & Jenny show so far, and in the previous episode (167) I read her essay on the crisis directly, How Coronavirus is Speeding Us Toward Transparency. If you’d like to submit a question for us for a future episode visit http://PivotMethod.com/ask » Special announcement! Penney will also be our featured guest for April’s Pivot Insider live video Q&A session. It will be on Wednesday, April 8 at 3:30pm ET. Join us at http://PivotMethod.com/insider by supporting the podcast with a small monthly donation, and you’ll also get instant access to 7+ months of archives and a slew of bonus resources, including a two-hour Upgrade Your Energy workshop. View full show notes from this episode at http://pivotmethod.com/169 »

BACKGROUND: Since 2011, Quesada Cigars has released its own Oktoberfest line of cigars, which are blended to be paired with beer. The line was introduced in two sizes initially, but since then the Oktoberfest line has become an annual release … Continue reading →

Background: Since the pig is one of the most important livestock animals worldwide, mapping loci that are associated with economically important traits and/or traits that influence animal welfare is extremely relevant for efficient future pig breeding. Therefore, the purpose of this study was a genome-wide mapping of quantitative trait loci (QTL) associated with nine body composition and bone mineral traits: absolute (Fat, Lean) and percentage (FatPC, LeanPC) fat and lean mass, live weight (Weight), soft tissue X-ray attenuation coefficient (R), absolute (BMC) and percentage (BMCPC) bone mineral content and bone mineral density (BMD). Methods: Data on the nine traits investigated were obtained by Dual-energy X-ray absorptiometry for 551 pigs that were between 160 and 200 days old. In addition, all pigs were genotyped using Illumina's PorcineSNP60 Genotyping BeadChip. Based on these data, a genome-wide combined linkage and linkage disequilibrium analysis was conducted. Thus, we used 44 611 sliding windows that each consisted of 20 adjacent single nucleotide polymorphisms (SNPs). For the middle of each sliding window a variance component analysis was carried out using ASReml. The underlying mixed linear model included random QTL and polygenic effects, with fixed effects of sex, housing, season and age. Results: Using a Bonferroni-corrected genome-wide significance threshold of P < 0.001, significant peaks were identified for all traits except BMCPC. Overall, we identified 72 QTL on 16 chromosomes, of which 24 were significantly associated with one trait only and the remaining with more than one trait. For example, a QTL on chromosome 2 included the highest peak across the genome for four traits (Fat, FatPC, LeanPC and R). The nearby gene, ZNF608, is known to be associated with body mass index in humans and involved in starvation in Drosophila, which makes it an extremely good candidate gene for this QTL. Conclusions: Our QTL mapping approach identified 72 QTL, some of which confirmed results of previous studies in pigs. However, we also detected significant associations that have not been published before and were able to identify a number of new and promising candidate genes, such as ZNF608.

Background: Since the times of domestication, cattle have been continually shaped by the influence of humans. Relatively recent history, including breed formation and the still enduring enormous improvement of economically important traits, is expected to have left distinctive footprints of selection within the genome. The purpose of this study was to map genome-wide selection signatures in ten cattle breeds and thus improve the understanding of the genome response to strong artificial selection and support the identification of the underlying genetic variants of favoured phenotypes. We analysed 47,651 single nucleotide polymorphisms (SNP) using Cross Population Extended Haplotype Homozygosity (XP-EHH). Results: We set the significance thresholds using the maximum XP-EHH values of two essentially artificially unselected breeds and found up to 229 selection signatures per breed. Through a confirmation process we verified selection for three distinct phenotypes typical for one breed (polledness in Galloway, double muscling in Blanc-Bleu Belge and red coat colour in Red Holstein cattle). Moreover, we detected six genes strongly associated with known QTL for beef or dairy traits (TG, ABCG2, DGAT1, GH1, GHR and the Casein Cluster) within selection signatures of at least one breed. A literature search for genes lying in outstanding signatures revealed further promising candidate genes. However, in concordance with previous genome-wide studies, we also detected a substantial number of signatures without any yet known gene content. Conclusions: These results show the power of XP-EHH analyses in cattle to discover promising candidate genes and raise the hope of identifying phenotypically important variants in the near future. The finding of plausible functional candidates in some short signatures supports this hope. For instance, MAP2K6 is the only annotated gene of two signatures detected in Galloway and Gelbvieh cattle and is already known to be associated with carcass weight, back fat thickness and marbling score in Korean beef cattle. Based on the confirmation process and literature search we deduce that XP-EHH is able to uncover numerous artificial selection targets in subpopulations of domesticated animals.

Background: Since the early 1990s more than 1,800 patients with lesions suspicious for Buruli ulcer disease (BUD) have been reported from Togo. However, less than five percent of these were laboratory confirmed. Since 2007, the Togolese National Buruli Ulcer Control Program has been supported by the German Leprosy and Tuberculosis Relief Association (DAHW). Collaboration with the Department for Infectious Diseases and Tropical Medicine (DITM), University Hospital, Munich, Germany, allowed IS2404 PCR analysis of diagnostic samples from patients with suspected BUD during a study period of three years. Methodology/Principal Findings: The DAHW integrated active BUD case finding in the existing network of TB/Leprosy Controllers and organized regular training and outreach activities to identify BUD cases at community level. Clinically suspected cases were referred to health facilities for diagnosis and treatment. Microscopy was carried out locally, external quality assurance (EQA) at DITM. Diagnostic samples from 202 patients with suspected BUD were shipped to DITM, 109 BUD patients (54%) were confirmed by PCR, 43 (29.9%) by microscopy. All patients originated from Maritime Region. EQA for microscopy resulted in 62% concordant results. Conclusions/Significance: This study presents a retrospective analysis of the first cohort of clinically suspected BUD cases from Togo subjected to systematic laboratory analysis over a period of three years and confirms the prevalence of BUD in Maritime Region. Intensified training in the field of case finding and sample collection increased the PCR case confirmation rate from initially less than 50% to 70%. With a PCR case confirmation rate of 54% for the entire study period the WHO standards (case confirmation rate >= 50%) have been met. EQA for microscopy suggests the need for intensified supervision and training. In January 2011 the National Hygiene Institute, Lome, has assumed the role of a National Reference Laboratory for PCR confirmation and microscopy.

Background: Since 2002 MI and stroke, not cancer, are leading causes of death in women. We studied 30-days and 1 year mortality of 3441 patients undergoing coronary artery bypass grafting (CABG) operations in our institution performed either conventionally or off pump (OPCAB). Our objective was to investigate the gender-related mortality in both groups. Patients and Methods: Between 2004 and 2008, 3441 patients (733 women, 2708 men) underwent CABG. 252 women and 854 men were operated using OPCAB, 481 women and 1854 men using extracorporeal circulation (ECC). Medical data was prospectively entered and retrospectively reviewed. 30-days and one year mortality rates were analyzed with Kaplan-Meier estimates and Cox proportional hazards models. Linear and logistic regression models were used to test gender differences. Results: a) 30-day mortality using ECC: 5.2% in women vs. 2.5% in men (p = 0.001). One year ECC mortality: 8.7% in women vs. 4.8% in men (p = 0.0008). b) OPCAB: 30-days and 1 year mortality in women measured 1.7%. Mortality in men was 2.1% after 30 days and 3.7% after one year c) gender specific mortality: 30 days mortality in women was 1.7% using OPCAB and 5.2% using ECC (p = 0.002), one year mortality in women was 1.7% using OPCAB vs. 8.7% using ECC (p = 0.0004). In men, 30-days mortality in OPCAB was 2.1%, one year mortality was 3.7%; using ECC early and late mortality was 2.5% and 4.8%. Conclusions: Female gender is a strong independent predictor and risk factor of increased early and midterm postoperative mortality rates when ECC is used. OPCAB significantly reduces early and midterm postoperative mortality in women and may therefore be proposed as the preferred revascularization technique in female patients.