Podcasts about Differential

FPL GW17 Tips, Transfer Targets & Chip Strategy! Arsenal only just get past Wolves this week, but that's what Champions do! Elsewhere Ekitike looks like he'll keep Isak out the Liverpool team ahead of a nice run of fixtures for the Reds and a finally, Lee picks a decent differential. A massive THANK YOU for all your support watching, liking and sharing our videos! __________________________  

FPL managers now have five Free Transfers to help them react to any of their players departing for the Africa Cup of Nations (AFCON), but what's the best way to use this early Christmas gift?

Nephrotic Syndrome explained clearly (including differences from Nephritic Syndrome), looking at causes and pathophysiology, as well as symptoms, diagnosis and treatment options. PDFs available at: https://rhesusmedicine.com/pages/nephrologyConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 Nephrotic vs Nephritic Syndrome1:02 Nephrotic Syndrome Pathophysiology2:01 Nephrotic Syndrome Signs and Symptoms 4:42 Nephrotic Syndrome Causes 7:34 Nephrotic Syndrome Epidemiology / Risk Factors8:07 Nephrotic Syndrome Diagnosis9:15 Nephrotic Syndrome Treatment LINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Nephrotic Syndrome in Adults. Last reviewed 2025. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adultsWikipedia contributors. Nephrotic syndrome. Last updated July 2025. Available at: https://en.wikipedia.org/wiki/Nephrotic_syndromeStatPearls. Nephrotic Syndrome. In StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available at: https://www.statpearls.com/articlelibrary/viewarticle/25713/Geeky Medics. Nephrotic vs Nephritic Syndrome | Renal. Last updated August 2025. Available at: https://geekymedics.com/nephrotic-vs-nephritic-syndrome/AMBOSS. Nephrotic syndrome. Last updated March 2025. Available at: https://www.amboss.com/us/knowledge/Nephrotic_syndromePubMed. Thrombosis in nephrotic syndrome. Published 2013. Available at: https://pubmed.ncbi.nlm.nih.gov/23625754/BMJ Best Practice. Assessment of nephrotic syndrome – Differential diagnosis of symptoms. Last updated March 2025. Available at: https://bestpractice.bmj.com/topics/en-gb/356Italian Journal of Pediatrics (Biomed Central). The Italian Society for Pediatric Nephrology (SINePe) consensus document on the management of nephrotic syndrome in children: Part I – Diagnosis and treatment of the first episode and the first relapse. Published 2017. Available at: https://ijponline.biomedcentral.com/articles/10.1186/s13052-017-0356-xDisclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice

Welcome to the fourth episode of our Early Clinical Learners Series, a series dedicated to fostering clinical reasoning skills and strategies in early clinical trainees. This episode focuses on the musculoskeletal (MSK) block and uses a clinical case to guide listeners through approaching joint pain, identifying key red flags, and narrowing a differential diagnosis.Hosts: Caroline Wang, Samantha Shih, Dr. Richard AbramsGuests: Christopher Song, Grant PrimerProduced By: Caroline Wang, Samantha ShihAlert & Oriented is a medical student-run clinical reasoning podcast dedicated to providing a unique platform for early learners to practice their skills as a team in real time. Through our podcast, we strive to foster a learning environment where medical students can engage with one another, share knowledge, and gain valuable experience in clinical reasoning. We aim to provide a comprehensive and supportive platform for early learners to develop their clinical reasoning skills, build confidence in their craft, and become the best clinicians they can be.Follow the team on Twitter:A&OA fantastic resource, by learners, for learners in Internal Medicine, Family Medicine, Pediatrics, Primary Care, Emergency Medicine, and Hospital Medicine.

Phil Foden is proving a popular purchase for FPL managers after his consecutive double-digit returns

It's the start of December, which means only one thing: festive fixtures. And lots of them ⚽️

In today's episode Guilaine responds to an email sent to her about the differential treatment of people of colour in the workplace, and why Black people are treated more harshly. This question was a response to a thread she made about the idealisation of Black people, and so this episode is also a follow up to the last episode where she spoke on that topic.She begins with an aside considering hierarchies of Racism under White Supremacy, particularly in relation to the UK, France and the USA.She then goes through examples of differential treatment across racial lines and shares some thoughts on the reasons why these patterns are engrained within white supremacist society.Subscribe, rate and review on Apple Podcasts, Spotify, Amazon Music or wherever you get your podcasts.

Tasty returns are potentially on the menu for FPL managers in Gameweek 13, with many activating a chip to try and gain those extra points

In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the November 2025 Emergency Medicine Practice article, Diagnosis and Management of Emergency Department Patients With Alcohol Withdrawal SyndromeEpidemiology & Background Rising ED visits related to alcohol use. Mortality rates and spectrum of patient presentations. Importance of high suspicion and complexity of cases.Pathophysiology & Mechanisms Alcohol metabolism and neurochemical changes. Differential diagnosis: Conditions that mimic alcohol withdrawal.Prehospital & EMS Considerations Role of EMS in triage and initial management. Use of sobering centers vs. ED transport. Prehospital administration of benzodiazepines (IM midazolam).History & Risk Assessment Key questions to assess risk for alcohol withdrawal syndrome. Importance of patient history, medication use, and comorbidities. Discussion on patient honesty and rapport.Physical Exam & Scoring Systems DSM-5 criteria for alcohol withdrawal. Use of CIWA-AR, BAWS, and PAWSS scoring systems. Importance of objective measurement for monitoring and disposition.Complications & Special PresentationsComplicated alcohol withdrawal: Hallucinosis, seizures, delirium tremens. Diagnostic workup: Labs, imaging, and co-ingestions. Special populations: End-stage liver disease, pregnancy, intubated patients.Treatment Strategies Mainstay: Benzodiazepines (types, dosing, and protocols). Phenobarbital: Indications, dosing, and evidence. Adjunctive therapies: Thiamine, glucose, magnesium. Alternative/adjunct medications: Gabapentin, ketamine, dexmedetomidine, baclofen.Clinical Pearls & Practice Changes Early, aggressive therapy to prevent complications. Symptom-based vs. fixed-schedule treatment. Gabapentin as an alternative or adjunct. Anti-craving medications for relapse prevention.Disposition & Protocols Use of scoring systems for safe discharge, observation, or admission. Importance of protocolized approaches and community resources.Summary & Take-Home Points Five key practice-changing points. Clinical pathway.Emergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

The international break has thrown us FPL managers a few headaches with some popular picks now flagged as injured

In this episode, we discuss patellofemoral pain (PFP). We explore: What is happening structurally in PFP? Differential diagnosis around the kneeRole of effusion and crepitus in PFPAssessment of patients with suspected PFPRole of squatting in objective assessments and treatmentWhat factors may lead to chronicityEvidence based management of PFPRole of blood flow restriction within PFPWant to learn more about patellofemoral pain? Claire Robertson has done a brilliant Masterclass with us called “Patellofemoral Pain” where she goes into further depth on this topic. 

Mike has project updates, Colin looks at a terrible 100 series Land Cruiser, and Sean has rapid fire automotive world news!

Author Reuben A. Buford May discusses the article, "Antiblack Discrimination in Public Accommodations: Differential Drink Pricing in Urban Nightclubs" published in Socius: Sociological Research for a Dynamic World.

With Arsenal performing so well, FPL managers are heavily invested in the Gunners but are we picking the right trio?

A region title decided by point differential? You won’t believe how North Cobb clinched it. In this playoff-packed episode of Cobb Football Friday, Brian Giffin and John Bednarowski break down the wild end to the regular season, historic scoring feats, and what’s ahead for Cobb County teams in the GHSA playoffs. From Walker’s gritty 23-man roster to McEachern’s record-breaking 79-point game, it’s a celebration of resilience, rivalry, and reclassification. Tune in for playoff previews, standout performances, and a look at how school enrollment is reshaping the future of Georgia high school football. Cobb Football Friday Chapters 00:00 Kickoff to Week 13: Playoff Fever and Fastball Season01:12 North Cobb’s Region Title: A Tiebreaker Twist02:30 Teams That Stepped Up: Harrison, Hillgrove, Sprayberry03:45 Campbell’s Quiet Success and Pope’s First Win04:36 Walker’s Grit and TJ Anderson’s 23-Man Miracle06:00 McEachern’s 79-Point Explosion and Historic Scoring Records07:30 Harrison vs. Marietta: Playoff Preview and Gate Expectations08:45 Hillgrove, Sprayberry, and Seeding Scenarios10:00 Campbell’s Winning Season and Whitfield’s Setback11:46 Walker’s Season Ends with Respect and Safety First12:30 First-Round Playoff Matchups Across Classifications14:53 GHSA Reclassification: Who’s Moving Up and Down17:21 Appeals, Region Realignment, and Travel Impacts19:47 North Cobb Christian’s Playoff Potential21:23 Cobb Stars in College: Kaden Lee and Connor Lu22:08 Travel Tales, Basketball, and Next Week’s Preview24:18 Bye Week Reflections and Playoff AnticipationSee omnystudio.com/listener for privacy information.

Jack Smith joins Papa & Silver to recap his experience doing play-by-play on the 49ers vs Giants broadcast, his real-time reaction to Mykel Williams' injury, what to make of the 49ers' negative turnover differential and moreSee omnystudio.com/listener for privacy information.

Jack Smith joins Papa & Silver to recap his experience doing play-by-play on the 49ers vs Giants broadcast, his real-time reaction to Mykel Williams' injury, what to make of the 49ers' negative turnover differential and moreSee omnystudio.com/listener for privacy information.

While more funds are being piled into the defence as we go big at the back, it means cheaper forward options are required, and the most popular purchase is Crystal Palace's Jean-Philippe Mateta

Differential diagnosis is part physiology, part detective work. Especially in heart failure, where similar vital signs can mean very different things.In this episode, Natalie RN is back on the show to break down two pediatric cases that looked almost identical on arrival to the ED but their workups led to two very different treatment plans. She shares the assessment findings, diagnostics, and clinical clues that helped them uncover what was really going on.Learn how to connect the dots and find the right intervention when presentations look identical!Topics discussed in this episode:Presentation of two pediatric patients with similar symptomsDifferential diagnosis and early clinical cluesWhat to look for in your clinical assessmentPathophysiology of pulmonary hypertensionPathophysiology of dilated cardiomyopathyKey physical exam and diagnostic differencesDilated cardiomyopathy interventionsWhy it's hard to diagnose pulmonary hypertension in the ERNurse priorities when managing patients in the CVICUManaging pulmonary hypertension crises and reducing PVRPearls and pitfalls of treating these conditionsConnect with Natalie:https://www.instagram.com/chatwithnat_rn/Listen to Chat with Nurse Nat on Spotify:https://open.spotify.com/show/7Jh2qe44KipudVKkdXFwWHListen to Chat with Nurse Nat on Apple Podcasts:https://podcasts.apple.com/us/podcast/chat-with-nurse-nat/id1815541418Mentioned in this episode:CONNECT

There's been a tactical shift in the game as the top FPL managers play more defensive assets and use formations with at least four at the back

Send us a textThe line between genuine ADHD and everyday distractibility can feel blurry—until you know what to look for. We open the case file and walk through a clear, practical way to identify ADHD: symptoms that begin before age twelve, persist over time, and cause real impairment across settings like home, school, and friendships. No shortcuts, no vibes—just a grounded approach that blends criteria with real-life context.Together, we unpack what inattention really looks like beyond “spacing out,” and how hyperactivity differs from normal kid energy by its severity, persistence, and resistance to willpower. You'll hear the exact questions we use when assessing teens and adults, how to gather collateral from parents and teachers, and the surprising role sleep plays in amplifying or masking symptoms. We also map the classroom realities: the fidgeting that never ends, the detours under desks, and the conversational zigzags that jump tracks from hot dogs to Hawaii.Differential diagnosis is the make-or-break step, so we draw sharp lines between ADHD and common lookalikes. Depression can tank concentration, but usually in episodes; PTSD may mimic restlessness and distractibility in kids, especially when hypervigilance is high; intermittent explosive disorder shares impulsivity but adds consistent aggression. Understanding these differences protects against misdiagnosis and steers better care—behavioral strategies, school supports, coaching, and when appropriate, medication. If you're studying the DSM-5-TR or navigating a possible diagnosis for yourself or a child, this conversation gives you a field-tested checklist and a narrative lens to see the whole person, not just a list of symptoms.If this helped clarify the ADHD picture, follow the show, share this episode with someone who needs it, and leave a quick review to help others find thoughtful mental health content.If you need to study for your national licensing exam, try the free samplers at: LicensureExamsThis podcast is not associated with the NBCC, AMFTRB, ASW, ANCC, NASP, NAADAC, CCMC, NCPG, CRCC, or any state or governmental agency responsible for licensure.

Differential diagnosis... I think they all just wanted to get out of recording in person. Send us your episode ideasL pleasedontcast@gmail.com

Bobby and Steve broke down the Saints' 26-15 victory over the New York Giants. Bobby slammed the Giants, calling them the New York "munchkins." The Cajun Cannon criticized the Saints' red zone offense, celebrated their +5 turnover differential, and praised the performance of New Orleans' young secondary. The guys spoke to WWL listeners about the win, K Blake Grupe, and a questionable "roughing the passer" call on Saints DE Carl Granderson. They also listened to QB Spencer Rattler's postgame press conference.

Bobby and Steve broke down the Saints' 26-15 victory over the New York Giants. Bobby slammed the Giants, calling them the New York "munchkins." The Cajun Cannon criticized the Saints' red zone offense, celebrated their +5 turnover differential, and praised the performance of New Orleans' young secondary. The guys spoke to WWL listeners about the win, K Blake Grupe, and the questionable "roughing the passer" call on Saints DE Carl Granderson. They also listened to QB Spencer Rattler's postgame press conference.

With the fixtures turning in Arsenal's favour, now's the time to consider a triple-up. But who to get?

Sheil Kapadia joins the 94 WIP Morning Show to analyze the Eagles' 4-0 start. He highlights the strong play from the defense and special teams, but also explains why the offense still raises concerns — even beyond the A.J. Brown social media drama.

Dr. Shau-Ming Wei (National Institute of Mental Health, Bethesda, MD) joins AJP Audio to discuss a replication study looking at impact of hormone addback to a hormone suppression regimen for the treatment of premenstrual dysphoric disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the October issue of the Journal.  00:34   Wei interview 02:59   PMDD 04:22   Up and downsides of hormone suppression 05:52   Hormone addback 07:15   Limitations of the current study 08:38   Further research 10:42   Kalin interview 10:58   Wei et al. 15:25   Sanacora et al. 20:07   Whittle et al. 23:06   Cooper et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Baskin and Phelps continue their discussion on the Guardians being playoff bound and talk about their confidence in the team despite the offensive struggles.

Plenty of Wildcards are being activated and almost all are doing so to bring in Man City forward Erling Haaland

Chinese Premier Li Qiang says the country will not seek any new special and differential treatment in the current and future World Trade Organization negotiations.

After playing an hour for Liverpool midweek, FPL managers are already starting to bring Alexander Isak into their teams. But have they gone too soon?

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the fastest-growing etiology of hepatocellular carcinoma (HCC). This work identifies novel gene and lipid associations in human MASLD-driven HCC that may be exploited for therapeutic benefit. Methods: Human HCC tumor (n=8) and adjacent non-tumor samples (n=8) were obtained from the Biospecimen Procurement and Translational Pathology Shared Resource Facility at the University of Kentucky Markey Cancer Center. All patients met cardiometabolic MASLD criteria and were negative for viral hepatitis. Hematoxylin and eosin (H&E) staining was used for pathological determination of tumor and adjacent nontumor tissue. Lipids were extracted using a methyl-tert-butyl ether extraction method and subjected to lipidomics by the West Coast Metabolomics Center. RNA was isolated and used for bulk sequencing. Data were analyzed using paired nonparametric analyses via a Wilcoxon or Mann-Whitney test, as appropriate. Results: Histological analysis by H&E showed significant lipid vacuole accumulation in HCC tumors relative to nontumor tissue. Lipidomic analysis revealed significant increases in long-chain nonesterified monounsaturated fatty acids (MUFAs; C16:1, C18:1, C20:1) and MUFA-enriched phospholipids (PC30:1, PC32:1, PE32:1, and PC36:1) in tumors relative to nontumor tissue. No significant differences were observed in nonesterified polyunsaturated fatty acids (PUFAs; C18:2, C20:4, and C22:6), PUFA-enriched phospholipids (C36:4, C38:4, C38:6, C40:6), or in fatty acid esters of hydroxy fatty acids (FAHFAs; C38:2, C38:4, C38:6). However, both MUFA- (C14:1, C18:1) and PUFA-enriched acylcarnitines (C18:2, C18:3) were collectively reduced in human tumors. Differential analysis of RNA sequencing revealed fatty acid oxidation genes (CPT1A, CPT2, ACADL, ACADM, ACADS, HADHA) were significantly reduced in tumor versus nontumor tissue. Further, genes involved in de novo lipogenesis were largely dysregulated (e.g. no differences in SREBF1 or FASN; increases in ACLY, ACACA, and SCD1; decreases in ACSL1) in tumor versus nontumor tissue. Conclusions: These results suggest human HCC tumors exhibit a reduced capacity to undergo mitochondrial β-oxidation resulting in accumulation of free and esterified MUFAs with concomitant reductions in MUFA-carnitines. Current studies are underway to determine the mechanisms by which impairment of hepatic MUFA catabolism via FAO promotes the development of HCC in mice.

In this episode of Through a Therapist's Eyes, we unpack the often-misunderstood world of Obsessive-Compulsive Personality Disorder (OCPD) and explore how it differs from both everyday perfectionism and OCD. From the importance of accurate differential diagnosis to the ego-syntonic traits that make OCPD so challenging to recognize, we highlight how this disorder impacts relationships, marriages, and workplace dynamics. Using a case illustration and insights from marriage research, we discuss how rigidity and control can create friction while offering practical strategies for individuals, partners, and clinicians to foster awareness, flexibility, and healthier connections. Tune in to see OCPD Through a Therapist's Eyes.  

Ein Vortrag der Primaten- und Kognitionsforscherin Julia FischerModeration: Katrin Ohlendorf**********Je älter wir werden, desto klarer wird, dass Alterung uns betrifft. Was können wir in Bezug auf das Altern von unseren Artverwandten, den Affen, lernen? Ein Vortrag der Primaten- und Kognitionsforscherin Julia Fischer.Julia Fischer leitet die Abteilung Kognitive Ethologie am Deutschen Primatenzentrum und ist Professorin für Primatenkognition an der Universität Göttingen. Ihr Forschungsinteresse gilt dem Sozialverhalten, der Kommunikation und der Kognition nichtmenschlicher Primaten.Im Jahr 2025 hat sie die Johannes Gutenberg-Stiftungsprofessur an der Universität Mainz übernommen. In diesem Rahmen hielt sie eine Studium-Generale-Vorlesungsreihe mit dem Titel "Der Mensch im Spiegel des Affen – Zur Evolution von Sozialverhalten, Kommunikation und Intelligenz bei Primaten". Ihr Vortrag "Kommunikation – Wie Affen kommunizieren und was uns das über den Sprachursprung verrät" wurde am 20. Mai 2025 aufgezeichnet.**********Schlagworte: +++ Wissenschaft +++ Primaten +++ Kognitionsforschung +++ Evolution +++ Affe +++ Mensch +++ Schimpansen +++ Meerkatzen +++ Paviane +++ Tiere +++ Afrika +++ Forschung +++ Altern +++ Alter +++ Demographischer Wandel +++ Sozialleben +++ Alleinsein +++ Einsamkeit +++ Lebensplanung +++ Bucketlist +++ Alterung +++**********Quellen aus der Folge:Carstensen, L. L., Isaacowitz, D. M., & Charles, S. T. (1999). Taking time seriously: A theory of socioemotional selectivity. American Psychologist, 54(3), 165–181.Almeling, L., Hammerschmidt, K., Sennhenn-Reulen, H., Freund, A. M., Fischer, J. (2016). Motivational Shifts in Aging Monkeys and the Origins of Social Selectivity. Current Biology, 26.13 (2016), pp. 1744–49.Rathke E.-M., Fischer J. Social aging in male and female Barbary macaques. Am J Primatol. 2021 Nov; 83(11).Rathke E.-M., Fischer J. (2020): Differential ageing trajectories in motivation, inhibitory control and cognitive flexibility in Barbary macaques (Macaca sylvanus). Philos Trans R Soc Lond B Biol Sci. 2020 Nov 9. https://doi.org/10.1098/rstb.2019.0617 Bosshard, T., Roger, M. & Julia, F. (2024). Ecological risk-taking across age in Barbary macaques. (Preprint)**********Mehr zum Thema bei Deutschlandfunk Nova:Primatenforschung: Vorsicht, Leopard! Wie Affen sich verständigenLebenserwartung: Die Biologie des AlternsPopulationsgenetik: Menschheitsgeschichte in den Genen ablesen**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

We break down pneumothorax: risks, diagnosis, and management pearls. Hosts: Christopher Pham, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Pneumothorax.mp3 Download Leave a Comment Tags: Chest Trauma, Pulmonary, Trauma Show Notes Risk Factors for Pneumothorax Secondary pneumothorax Trauma: rib fractures, blunt chest trauma (as in the case). Iatrogenic: central line placement, thoracentesis, pleural procedures. Primary spontaneous pneumothorax Young, tall, thin males (10–30 years). Connective tissue disorders: Marfan, Ehlers-Danlos. Underlying lung disease: COPD with bullae, interstitial lung disease, CF, TB, malignancy. Technically, anyone is at risk. Symptoms & Differential Diagnosis Typical PTX presentation: Dyspnea, chest pain, pleuritic discomfort. Exam clues: unilateral decreased breath sounds, focal tenderness/crepitus. Red flags (suggest tension PTX): JVD Tracheal deviation Hypotension, shock physiology Severe tachycardia, hypoxia Differential diagnoses: Pulmonary: asthma, COPD, pneumonia, pulmonary edema (SCAPE), ILD, infections. Cardiac: ACS, CHF, pericarditis. PE and other acute causes of dyspnea. Diagnostics Bloodwork: limited role, except type & screen if intervention likely. EKG: reasonable given chest pain/shortness of breath.

With the international break on the horizon and some underwhelming form, Kelly Somers and the FPL Pod team debate whether we should be removing Cole Palmer from our teams

Mike Schopp talks to Bills fans about the Bills turnover differential from last year and if that is obtainable again

Ekitiké One Gameweek into the new season and FPL managers are already trying to rip up their teams and start again

In this episode of the Epigenetics Podcast, we talked with Luca Magnani from Institute of Cancer Research and UNIMI in Milan about his work on epigenetic mechanisms of drug resistance and cancer cell dormancy in breast cancer. We start the interview by putting our focus on his significant contributions to the understanding of estrogen receptor-positive breast cancer. In a foundational study from 2013, Professor Magnani and his colleagues illuminated the role of genome-wide reprogramming of the chromatin landscape in conferring resistance to endocrine therapy. This research marked a departure from a purely genetic mutation paradigm, proposing instead that epigenetic modifications play a pivotal role in the development of drug resistance. A fascinating part of our conversation centers on the role of pioneer transcription factors, particularly PBX1, in regulating the estrogen receptor's transcriptional response. Professor Magnani explains how PBX1, typically associated with hematopoietic development, influences estrogen receptor activity, thereby shaping the cancer cell's fate and response to treatment. Continuing our exploration, we discuss the critical distinctions between primary and metastatic breast cancer through the lens of epigenetic reprogramming. By analyzing samples from women with breast cancer, Professor Magnani's work identifies specific enhancer usage that marks the transition to a drug-resistant state which was a breakthrough in linking epigenetic alterations to real-world patient outcomes. He emphasizes that the reliance on genetic mutations alone does not adequately explain the mechanisms of drug resistance, pushing the field to consider the epigenetic landscape more deeply. Our conversation also touches on the evolution of experimental techniques. Professor Magnani shares insights into the transition from traditional ChIP-seq methods to CUT&RUN, demonstrating the need for techniques that cater to the limited material available from clinical samples. This adaptability mirrors the dynamic nature of cancer itself, as cells continuously evolve under therapeutic pressure. As we traverse through the complexities of dormancy and reactivation in cancer cells, Professor Magnani enlightens us on the unpredictable nature of tumor behavior. He describes how cancer cells can enter dormant states and how their awakening is influenced by environmental factors, akin to an evolutionary response to stressors, thus revealing the intricate balance between survival and proliferation. In the latter part of the episode, we explore Professor Magnani's vision for the future of breast cancer research, which includes the need for better animal models that mimic human disease. His pursuit of understanding estrogen receptor behavior both in healthy and cancerous cells reflects a holistic approach to cancer biology, aiming to decipher the transition from normal tissue to malignancy.   References Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T. L., Gyorffy, B., & Lupien, M. (2013). Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1490–E1499. https://doi.org/10.1073/pnas.1219992110 Nguyen, V. T., Barozzi, I., Faronato, M., Lombardo, Y., Steel, J. H., Patel, N., Darbre, P., Castellano, L., Győrffy, B., Woodley, L., Meira, A., Patten, D. K., Vircillo, V., Periyasamy, M., Ali, S., Frige, G., Minucci, S., Coombes, R. C., & Magnani, L. (2015). Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature communications, 6, 10044. https://doi.org/10.1038/ncomms10044 Patten, D. K., Corleone, G., & Magnani, L. (2018). Chromatin Immunoprecipitation and High-Throughput Sequencing (ChIP-Seq): Tips and Tricks Regarding the Laboratory Protocol and Initial Downstream Data Analysis. Methods in molecular biology (Clifton, N.J.), 1767, 271–288. https://doi.org/10.1007/978-1-4939-7774-1_15   Related Episodes Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Contribution of Estrogen Receptor to Breast Cancer Progression (Jason Carroll) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Dr. Benedict Nwachukwu joins host Phil Plisky to take a deep dive into hip impingement and labral tears. With insights shaped by both surgical expertise and personal experience as an athlete, Dr. Ben shares what really drives the decision between rehab and surgery. Together, they unpack how rehab professionals like you can navigate the gray areas with confidence and clarity. Don't miss this thoughtful conversation on what the latest research means for your patients—and your practice.Learning ObjectivesAnalyze the evidence around hip preservation strategiesApply evidence-based, practical strategies to actionably address conservative and postoperative hip joint pathologySolve patient case scenarios involving postoperative hip labral repair and reconstructionTimestamps(00:00:00) Welcome(00:01:25) Introduction to guest(00:03:33) Introduction to hip labral tears and impingement(00:08:13) Understanding hip anatomy and impingement(00:16:30) The interplay of hip and spine(00:22:23) Differential diagnosis of hip conditions(00:25:26) Current research on hip management(00:30:46) Indications for a surgical referral(00:36:07) Postoperative rehabilitation process(00:42:28) Comparisons to ACL reconstruction(00:47:19) Postoperative dos and don'ts(00:55:40) Case study: a journey through hip surgery(00:59:24) Key takeaways and future directionsRehab and Performance Lab is brought to you by Medbridge. If you'd like to earn continuing education credit for listening to this episode and access bonus takeaway handouts, log in to your Medbridge account and navigate to the course where you'll find accreditation details. If applicable, complete the post-course assessment and survey to be eligible for credit. The takeaway handout on Medbridge gives you the key points mentioned in this episode, along with additional resources you can implement into your practice right away.To hear more episodes of Rehab and Performance Lab, visit ⁠⁠⁠⁠https://www.medbridge.com/rehab-and-performance-lab⁠⁠⁠⁠If you'd like to subscribe to Medbridge, visit ⁠⁠⁠⁠https://www.medbridge.com/pricing/

The time for tweaking your squad is almost over, so Kelly Somers and the FPL Pod team are here to give you some last-minute advice

Here it is folks, the third and final installment on our mini-series about building trust! Thank you all so much for your patience, for listening, for learning, that's the attitude to have when entering the communal thought Schauer! We're sharing cognitive load and helping each other co-regulate [somewhat parasocial conclusion redacted for posterity purposes] so thank you. Can't wait to talk to you all next week about something tangentially related. Make sure to like and subscribe on Youtube, as well as rate 5 stars on Spotify or Apple Podcasts! This year, skip breaking a sweat AND breaking the bank. Get this new customer offer and your 3-month Unlimited wireless plan for just 15 bucks a month at https://MintMobile.com/SCHAUER Upfront payment of $45 required (equivalent to $15/mo.). Limited time new customer offer for first 3 months only. Speeds may slow above 35GB on Unlimited plan. Taxes & fees extra. See MINT MOBILE for details. Resources: Four Colors of Lies http://changingminds.org/explanations/behaviors/lying/four_lies.htm An Illustrated Guide to the 4 Types of Liars https://www.nirandfar.com/types-of-liars/ Visual Perception and Corollary Discharge  https://pmc.ncbi.nlm.nih.gov/articles/PMC2807735/#:~:text=Identifying%20a%20corollary%20discharge%20in,Holst%20and%20Mittelstaedt%2C%201950). Propensity to trust and risk aversion: Differential roles in the trust process https://www.sciencedirect.com/science/article/abs/pii/S0092656623000119 Agreeableness https://www.psychologytoday.com/us/basics/agreeableness 12 Proven Trust-Building Exercises to Repair Relationships of All Types https://riveroakspsychology.com/12-proven-trust-building-exercises-to-repair-relationships-of-all-types/ 5 Creative Bullet Journal Mood Tracker Ideas [and Your How To Guide] https://www.yopandtom.com/blogs/news/5-creative-bullet-journal-mood-tracker-ideas-and-your-how-to-guide?srsltid=AfmBOoq1RVxbyYU_8b-31IJzxvrtezmy64Xyp8zdmgBUp3lJnyoyDhto Lying: Moral Choice in Public and Private Life - Sissela Bok The Order of Time - Carlo Rovelli Learn more about your ad choices. Visit podcastchoices.com/adchoices

After a busy week of tinkering with our first squad drafts, Kelly Somers and the FPL Pod team are back to look over their changes and chat about which premiums to pick ♻️

In this episode of Breaking Math, Autumn explores the complex world of AI ethics, focusing on its implications in education, the accuracy of AI systems, the biases inherent in algorithms, and the challenges of data privacy. The discussion emphasizes the importance of ethical considerations in mathematics and computer science, advocating for transparency and accountability in AI systems. Autumn also highlights the role of mathematicians in addressing these ethical dilemmas and the need for society to engage critically with AI technologies.Takeaways AI systems can misinterpret student behavior, leading to false accusations. Bias in AI reflects historical prejudices encoded in data. Predictive analytics can help identify at-risk students but may alter their outcomes. Anonymization of data is often ineffective in protecting privacy. Differential privacy offers a way to share data while safeguarding individual identities. Ethics should be a core component of algorithm design. The impact of biased algorithms can accumulate over time. Mathematicians must understand both technical and human aspects of AI. Society must question the values embedded in AI systems. Small changes in initial conditions can lead to vastly different outcomes.Chapters 00:00 Introduction to AI Ethics 02:14 The Accuracy and Implications of AI in Education 04:14 Bias in AI and Its Consequences 05:45 Data Privacy Challenges in AI 06:37 Mathematical Solutions for Ethical AI 08:04 The Role of Mathematicians in AI Ethics 09:42 The Future of AI and Ethical ConsiderationsSubscribe to Breaking Math wherever you get your podcasts.Become a patron of Breaking Math for as little as a buck a monthFollow Breaking Math on Twitter, Instagram, LinkedIn, Website, YouTube, TikTokFollow Autumn on Twitter and InstagramBecome a guest hereemail: breakingmathpodcast@gmail.com

Graeme Findlay visits the swamp and brings his Differential Voice leadership meta-model. Graeme makes the case that to lead effectively today, a leader needs more than one voice.  Graeme has us covered: his differential voice approach is based on six major ‘modes' of leading. Take note as Graeme leads us through when and how we use these different leadership voices.Graeme's LinksWebsiteDifferential VoiceBlogLeadership ProgrammeThanks for listening. Send me your feedbackI want to thank my great team that helps me sound better than I am. Jacki Hydock for her lending her wonderful voice to our introduction and outro Great music by Jazz Night Awesome episode production by the great team of We Edit Podcasts all the way up in Calgary, Alberta, Canada. Check them out at www.weeditpodcasts.com Thanks For Listening and Jumping into the Swamp

Jeff Blair and Kevin Barker kick off the second hour with reaction to the All-Star teams, with Vladimir Guerrero Jr. getting the honour for a fifth time. ESPN MLB insider Jeff Passan (3:24) stops by to discuss MLB's gambling investigation on Luis Ortiz, the Jays' place atop the AL East despite a meagre run differential, and their chances at holding on to the division lead through this season. Later, Yankees analyst Pete Caldera (25:55) helps tee up the series finale between the Yanks and Blue Jays and discusses what Brian Cashman will need to prioritise at the trade deadline, whether this is the best version of Aaron Judge and the team's future at shortstop.The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the position of Rogers Sports & Media or any affiliates.

92.9 The Game Atlanta Braves Insider and From The Diamond Host Grant McAuley talks about defending the Braves calling themselves a good team with a bad record, having to find some footing before starting to build back up, how the team should have avoided what happened with Craig Kimbrel, what is the plan at closer moving forward, and what the role might be for Jose Ruiz.

The Chicago Cubs lead MLB in run differential, but is it sustainable long-term? We break down Pete Crow-Armstrong's breakout, Kyle Tucker's red-hot week, and Matt Shaw's impressive emergence in the Cubs' lineup. With bullpen injuries piling up, Cade Horton and other young arms are being thrown into high-leverage roles. Tune in as the CHGO Cubs crew analyzes what's real, what's not, and what's next for this red-hot Cubs team.

Dr. Bill Ahearn joins me in Session 299 of Behavioral Observation. I met Bill a few times at conferences and I'm so glad we finally had a chance to sit down and record a podcast together. Bill is the Director of Research at The New England Center for Children. Long time listeners may recall that NECC sponsored a series of episodes, and in this podcast, we talked about some of the great research that has come out of that storied institution. As an aside, if you want to learn more about NECC, particularly working at NECC, you can find more information about that here. We covered a lot of ground in this conversation, including: Bill's early experiences as a grad student and clinician. His early work in addressing feeding problems. The research that he and his colleagues have conducted at NECC. How he construes stereotypic and self-injurious behavior as being forms of repetitive behavior. What he's learned about addressing stereotypy, including when and when not to intervene. We talk at length about Response Interruption and Redirection, particularly when it is and isn't necessary as an intervention. The behavioral interpretation of anxiety, and interventions that he and his team have brought to bear on related repertoires. I ask a few lighter questions on some topics of mutual interest (you'll have to listen towards the end to hear that). If you listen to nothing else from this podcast, towards the end of the show, Bill talks about why he is proud to be a Behavior Analyst. Please listen to that segment, as I think he makes some excellent points that are more than worth sharing. We also talked about tons of papers. I've done my best to track as many down as possible. Piazza et al. (2000). An evaluation of the effects of matched stimuli on behaviors maintained by automatic reinforcement. Rapp and Vollmer (2005). Stereotypy I: A review of behavioral assessment and treatment. Ahearn et al. (2007). Assessing and treating vocal stereotypy in children with autism. Colón et al. (2012). The effects of verbal operant training and response interruption and redirection on appropriate and inappropriate vocalizations. Rodriguez et al. (2013). Arranging and ordering in autism spectrum disorder: Characteristics, severity, and environmental correlates. Steinhauser et al. (2021). Examining stereotypy in naturalistic contexts: Differential reinforcement and context-specific redirection. Moore et al. (2022). Assessing and Treating Anxiety in Individuals with Autism. Fergus (2024). Functional Analysis and Delineating Subtypes of Restricted Repetitive Behavior in Individuals with Autism Spectrum Disorder. This podcast is brought to you by: Frontera. Consider taking a demo of Frontera's Assessment Builder and see how the ethical application of AI technologies can help you serve clients and save you time! Your first assessment report is free. And if you use code BOP25 you'll get an additional five assessments for just $100. So head to fronterahealth.com to check it out! CEUs from Behavioral Observations. Learn from your favorite podcast guests while you're commuting, walking the dog, or whatever else you do while listening to podcasts. New events are being added all the time, so check them out here.  The Behavioral Toolbox. Check out our courses for school-based and other behavioral professionals, including our newest one, Motivational Interviewing: Getting Educator Buy-In. Behavior University. Their mission is to provide university quality professional development for the busy Behavior Analyst. Learn about their CEU offerings, including their 8-hour Supervision Course, as well as their RBT offerings over at behavioruniversity.com/observations. Don't forget to use the coupon code, PODCAST to save at checkout!