Podcasts about snps

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Hi, I'm Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I've seen consistently in practice: the real root cause behind many cases on the spectrum.It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can't efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges.The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal.This isn't theory. It's the Purser Method® in action.If you're a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let's talk solutions.Reach to my office to get started: 801-796-7667 or info@danpursermd.com

You've seen this before. A genetic report comes back loaded with red SNPs. MTHFR. APOE. COMT, and suddenly everything feels more complicated. More supplements. More restrictions. More second-guessing.That creates overwhelm.In this episode, Dr. Ritamarie breaks down how to actually use genetics in practice without turning it into a list of problems to fix. SNPs aren't diagnoses, and they don't tell you what to do on their own.What matters is how those variants show up in the body.You'll learn how to step back, look at pathways instead of individual SNPs, and connect genetics with labs, symptoms, and physiology, so your decisions actually make sense.If genetic testing has ever made things harder instead of clearer, this will change how you approach it.What's Inside This Episode?• Why genetic testing often creates overwhelm instead of clarity • The problem with focusing on individual SNPs like MTHFR and APOE • Why SNPs are variants, not diagnoses or mutations • The shift from “red flags” to pathway-based thinking • How to integrate genetics with labs, symptoms, and physiology • What to look at instead of reacting to every variant • How to prioritize interventions using systems thinking • Why sequencing matters more than stacking protocolsResources and Links:Download the full transcript hereDownload our FREE Smart Supplementation MatrixJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out our other podcast episodes here

ITPM Flash provides insight into what professional traders are thinking about in the markets RIGHT NOW!   Software stocks are getting destroyed. AI infrastructure stocks are exploding.   And sitting right in the middle of that dislocation is Synopsys ($SNPS).   While names like Salesforce, Adobe, and ServiceNow have been crushed by fears that AI agents will destroy traditional SaaS models, the companies powering the AI infrastructure buildout have gone vertical.   But what if the market is completely mispricing Synopsys?   In this video, Raj Malhotra breaks down why Synopsys may not belong in the "software apocalypse" trade at all — and why it could actually be one of the most important AI infrastructure companies in the world.   Is Synopsys one of the most overlooked AI infrastructure plays in the market today? Watch now to find out.

Many who qualify for Chronic Condition Special Needs Plans (C-SNPs) find that this type of plan suits their specifics needs with tailormade benefits and networks. This episode of the Agent Survival Guide is your crash course in C-SNPs.    Read the text version    

In this powerful live session, Dan Purser MD reveals why conventional pediatric medicine often falls short and shares his proven Purser Method® for helping children with autism spectrum traits, severe ADHD, chronic inflammation, and developmental delays.Drawing from over 43 years of clinical experience, Dr. Purser explains:Why genetic testing (especially MTHFR and related SNPs) is the essential first stepHow to use targeted, active-form nutrients instead of generic vitaminsThe role of leucovorin (high-dose folinic acid) and when it makes a real differencePractical ways to reduce toxin load and calm the inflammatory responseSmart strategies around vaccination and detoxification supportDr. Purser emphasizes that kids are not little adults — their developing systems need precise, individualized care. Parents and practitioners will walk away with actionable steps that address root causes rather than just managing symptoms.Whether your child is struggling with speech delays, meltdowns, focus issues, or recurrent health problems, this episode offers real hope through biochemistry done right.Resources Mentioned:Full video replay: https://www.youtube.com/watch?v=Sbn8WrIrAt8Pediatric MTHFR formulas: https://www.PhysicianDesigned.comBook a consultation: http://www.DanPurserMD.comDr. Purser's books on Amazon: https://www.amazon.com/-/e/B00BIKSGVQIf you're a parent tired of “there's nothing more we can do,” or a practitioner looking for better tools, this episode is for you.Timestamps available in the full video.Subscribe, leave a review, and share this with any parent who needs to hear it. The kids deserve better answers.Dan Purser MD – Root Cause Inflammation & Genetic Optimization#MTHFR #Autism #ADHD #ChildrensHealth #Leucovorin #FunctionalMedicine #Pediatrics

In this episode of Hope Natural Health, Dr. Erin Ellis is joined by Dr. Alicia Newsome, a functional medicine expert and bestselling author, to pull back the curtain on hormone imbalances and the "burnout culture" facing high-achieving women. Dr. Alicia shares her personal journey from struggling with extreme exhaustion and "normal" lab results to founding the Body Wellness Institute. Together, they discuss the limitations of conventional medicine and how advanced diagnostic testing can provide the clarity women need to finally feel like themselves again.   In this episode, you will learn: Why standard blood work often fails to catch the root cause of fatigue and hormone issues, and what comprehensive functional testing actually looks like. How markers like MTHFR and methylation SNPs impact your ability to detoxify estrogen and manage your energy. Why your digestive health is the "second brain" and how it dictates your mood, immune system, and metabolic health. Strategies for executive-level women and busy moms to reclaim their time and use the power of "No" as a tool for adrenal recovery. A sneak peek into Dr. Alicia's upcoming book and why rest is a physiological necessity, not a luxury. Why starting your day with warm lemon water can support your liver, digestion, and lymphatic system.   Connect with Dr. Alicia Newsome: Website: www.dralicianewsome.com Instagram: @dr.alicianewsome LinkedIn: Dr. Alicia Newsome Book: Worthy of Rest   For more on Dr. Erin: Join The Hope Circle Community: https://hormonehealingproject.drerinellis.com/communities/groups/the-hope-circle/home?invite=69120d498b7e3f60397656b8 Work with Dr. Erin here: https://p.bttr.to/3E88ps4 Buy Dr. Erin's Supplements here: https://drerinellis.com/shop Get the Period Productivity Planner here: https://www.amazon.com/dp/B0BBYBRT5Q?ref_=pe_3052080_397514860 Download the FREE Menstrual Cycle Nutrition Guide here: https://detox.drerinellis.com/ Watch The Free Video "7 Hormones Affecting Your Weight Loss Goals" here: https://weightloss.drerinellis.com/   Let's Be Friends: Follow Dr. Erin on Instagram: https://www.instagram.com/dr.erinellis/ Follow Dr. Erin on Facebook: https://www.facebook.com/drerinellisnmd Follow Dr. Erin on TikTok: https://www.tiktok.com/@dr.erinellis?lang=en Join the Free Hope Circle Community: https://hormonehealingproject.drerinellis.com/communities/groups/the-hope-circle/home?invite=69120d498b7e3f60397656b8  Bookmark Dr. Erin's Website: www.drerinellis.com Subscribe to Hope Natural Health on YouTube: https://www.youtube.com/channel/UChHYVmNEu5tKu91EATHhEiA Follow Hope Natural Health on FB: https://www.facebook.com/hopenaturalhealth Sign up for Newsletters here:   https://booking.hopenaturalhealth.com/widget/form/VUubL7MNYELduwQL8ssI

This podcast is made possible by our listeners and viewers. If this show has brought you value, you can support it by becoming a member of The Way Forward, our platform designed to help you find the health and freedom community (people, practitioners, schools, farms, and more) near you. Your membership directly supports the podcast and the work we do.Use discount code THEWAYFORWARD for 10% off Better AromatherapyUse discount code THEWAYFORWARD for 10% off Nature's RootWhat if cannabis has been misunderstood not just culturally, but biologically and environmentally?In this conversation, Dani Fontaine draws on nearly two decades in the cannabis and hemp industries, where she's built companies, developed therapeutics, and led innovation in plant-based wellness. Her work ranges from creating hemp-derived body care and nutritional products to founding a terpene-focused aromatherapy company and the first hemp-based spa, all rooted in a broader view of sustainable health.We get into how epigenetics reframes the idea that genetics are fixed, and why expression is constantly shifting moment to moment. Dani explains how cannabinoids, terpenes, and other plant compounds influence cellular communication, and why focusing only on THC misses the larger picture.This conversation opens up a deeper look at coherence in the body, the role of plant intelligence, and how understanding your biological blueprint can change how you approach healing.You'll learn:[00:00] Introduction[08:18] What cannabis represents, and why it was buried by corporate interests[15:21] How THC is chemically turning men into passive, apathetic versions of themselves[22:44] When Dani got started, and the stage-four cancer patient who changed everything[31:17] The body's master balancing system, and why medicine never told you about it[53:06] Why 85% of people shouldn't use THC, and what it does to the ECS long-term[01:00:09] Cannabis, the big C, and how the plant houses every terpene on earth[01:21:59] How to rebalance your endocannabinoid system with Dani's 90-day protocol[01:37:44] Why the ECS is the master controller of everything happening inside your cells[02:05:30] Pain, somatic work, and the cannabis products built to go deeperRelated The Way Forward episodes:The 4th Phase of Water: The Blueprint for Biological Energy with Dr. Gerald Pollack | YouTubeResources mentioned:The Fourth Phase of Water: Beyond Solid, Liquid, and Vapor by Gerald Pollack | Book or AudiobookFind more from Dani:Dani Fontaine | InstagramMainspring Well Center | WebsiteBetter Aromatherapy | WebsiteNature's Root | WebsiteFind more from Alec:Alec Zeck | InstagramAlec Zeck | XThe Way Forward | InstagramDonate to The Way Forward here.The Way Forward is Sponsored By:Eating well shouldn't be complicated. Dr. Cowan's Garden makes it simple to increase your daily nutrient density with their signature vegetable powders, clean pantry staples, and pasture-raised products. Family-run and committed to "beyond-organic" quality.* Offer: Use code THEWAYFORWARD for 15% off your first order.* Shop: Dr. Cowan's GardenPACHA Sourdough: The wheat-free, sprouted buckwheat bread that actually digests well. Made with just two ingredients: organic sprouted buckwheat and sea salt. No gums, oils, or fillers.* Discount: Use code THEWAYFORWARD for 10% off.* Shop: Live PachaPaleoValley: 100% Grass-Fed Bone Broth Protein is a nutrient-dense, easy-to-digest source of collagen and essential amino acids. Sourced from grass-fed cows, this protein powder provides the building blocks for healthy joints, skin, and gut function—without fillers or artificial ingredients. Support the show and claim 15% off your PaleoValley order!

In this milestone 200th episode of Investing Unscripted (yes, the last episode was an April Fool's joke!), we tackle a question that plagues many investors: how many individual stocks should you actually own? We debate the merits of a heavily concentrated portfolio versus broad diversification, especially during periods of market uncertainty. We also unpack the psychological dangers of blindly adding to your winners and why it's crucial to adapt your investing strategy as your personal financial goals change over time.03:13 Spotify Ratings Challenge05:04 How Many Stocks06:30 Concentration vs Diversification09:06 Is This More Uncertain14:11 Should Uncertainty Change Holdings15:48 Jason Reframes Portfolio Size21:25 Portfolio Size Debate23:55 Conviction Versus Bias26:58 Averaging Up Winners28:42 Kinsale Capital Case32:59 Watchlist FOMO Trap34:48 Concentration And Time40:05 Automate When Anxious43:15 Humility And EvolvingCompanies mentioned: AAPL, AMZN, CDNS, CRWD, DFH, GE, JRVR, KNSL, MSFT, NVDA, S, SNPS, TOST, TTDFind where to listen & subscribe,  portfolio contests, and contact information at https://investingunscripted.com*****************************************To get 15% off any paid plan at fiscal.ai, visit https://fiscal.ai/unscriptedListen to the Chit Chat Stocks Podcast for discussions on stocks, financial markets, super investors, and more. Follow the show on Spotify, Apple Podcasts, or YouTube*****************************************Join our PatreonSubscribe to our portfolio on Savvy Trader

Learn about the value of Dual Eligible Special Needs Plans (D-SNPs) and how to get started selling! Read the text version   Learn how you can get started selling D-SNPs by calling Ritter Insurance Marketing today at 800-769-1847. Contact the Agent Survival Guide Podcast! Email us ASGPodcast@Ritterim.com or call 1-717-562-7211 and leave a voicemail.

SUMMARY DEL SHOW Wall Street vuelve a risk off. La guerra con Irán entra en su cuarta semana, Brent sigue arriba de $112 y la gasolina sube, reavivando miedo a inflación más alta y recortes de la Fed más lejanos. Elon Musk presenta “Terafab” en Austin junto a Tesla $TSLA y SpaceX, como apuesta de semiconductores e integración vertical para reducir dependencia de $TSM y $SSNLF. Berkshire $BRK.A y $BRK.B amplía exposición a Japón con Tokio Marine, y Synopsys $SNPS sube por reporte de participación activista de Elliott.

Today, I'm delighted to welcome Dr. Yael Joffe, a leading expert in nutrigenomics who speaks internationally at conferences on translating the science of genetics into clinical practice. She holds a PhD in nutrigenomics from the University of Cape Town, where her research focused on the genetics of obesity. I met Yael earlier this fall and decided to invite her on the podcast to explore the growing field of lifestyle genetics. In our conversation today, we dive into the effects of nutrigenomics, nutrition genetics, and SNPs, which she refers to as spelling changes in our DNA. We cover genetic testing in the industry, red flags, DNA health, and her polygenic approach to weight loss resistance. We also discuss both perimenopause and menopause from the perspective of genetics and epigenetics, and the role of insulin signalling and glucose. Yael's insights are deeply informative. Her pioneering work on 36 metabolic pathways and her ability to make complex genetic information accessible and actionable make this a truly invaluable conversation. IN THIS EPISODE, YOU WILL LEARN: Women and gaining weight after starting HRT Neurotransmitters and what they reveal about mood, anxiety, and addiction tendencies Why do certain people break down dopamine and serotonin either too fast or too slowly? How touch and genuine connection can switch on feel-good genes Sunlight, weather, and environment affect genetic expression. What acupuncture and infrared therapies do at the gene level Why hormones are only part of the picture when addressing midlife weight gain How glucose regulation and insulin sensitivity shift through menopause Dr. Joffe's polygenic testing model connects multiple pathways rather than single genes How Yael's approach to genetic testing differs from that of others in the field Bio: YAEL JOFFE, PhD  Yael is globally recognized as a leading expert in nutrigenomics. In 2000, she was part of the team that built the first lifestyle genetics test, and since then has been responsible for creating many others. She is the author of four books: The Power of Genetics, It's Not Just Your Genes, Genes to Plate, and SNP Journal. Yael has been published in multiple peer-reviewed scientific journals, hosts the Power of Genetics podcast, and is a highly regarded speaker in genetics. Yael built the first online nutrigenomics platform for clinician education and has developed and supervised genomics courses around the world. She has trained thousands of healthcare practitioners globally, also teaching at Rutgers University and the Maryland University of Integrative Health. In 2018, Yael founded 3X4 Genetics and now serves as its Chief Science Officer.    Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Yael Joffe 3X4 Genetics Instagram Facebook

Howie and Harlan are joined by geneticist and endocrinologist Joel Hirschhorn to discuss how thousands of genetic variants collectively shape disease and traits like height and obesity. Harlan reviews new research on diet soda and dementia; Howie surveys recent market swings, including the rise of Solace Health and the decline of Hims & Hers. Show notes: Diet Soda and Dementia "Soda consumption and risk of dementia: The Northern Manhattan study"  "Why One Cardiologist Has Drunk His Last Diet Soda" Joel Hirschhorn National Human Genome Research Institute: Mendelian Inheritance MedlinePlus: FGFR3 gene  Cleveland Clinic: Achondroplasia National Human Genome Research: Polygenic Trait  Hirschhorn Lab "A saturated map of common genetic variants associated with human height"  "What are single nucleotide polymorphisms (SNPs)?" ScienceDirect: Genetic Variant Joel Hirschhorn: "Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci" Joel Hirschhorn: "Polygenic prediction of body mass index and obesity through the life course and across ancestries" "Obesity Prediction Could Be Guided by Genetic Risk Scores" "Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia"  Society for Science: Noam Elkies MIT: Eric S. Lander Ups and Downs "Understanding Creative Destruction: Driving Innovation and Economic Change" "Solace Health raises $130M series C for advocacy platform" "Molina Healthcare's stocks fall as company plans exit from Medicare Advantage"  "Centene swings to loss but predicts stabilization in 2026" "UnitedHealth limps into 2026 with a smaller business and fresh challenges" "Hims & Hers Falls 14% After Pulling Copycat Wegovy Pill—Novo Nordisk Up 8%"  "Compounding and the FDA: Questions and Answers" In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.

In this episode of The Better Life, Dr. Pinkston sits down with Jaclyn Downs, MS, a certified functional genomics expert and author of Enhancing Fertility Through Functional Medicine. While many people have heard of the "MTHFR" gene, Jaclyn explains to Dr. Pinkston why that is only the tip of the iceberg. They delve into how functional genomics—the study of subtle genetic variations you can actually influence through diet and lifestyle—holds the key to solving chronic issues like infertility, anxiety, migraines, and poor detoxification. In this episode, you’ll learn: Genetics vs. Genomics: The difference between fixed mutations and "snips" (SNPs) that you can optimize with nutritional cofactors. The "Folate Trap": Why taking high doses of methylfolate can sometimes backfire if your B12 levels aren't addressed first. Beyond MTHFR: Why looking at the big picture (including pathways like glucuronidation and histamine metabolism) is vital for hormone health and longevity. Personalized Medicine: Why "automated" genetic reports often lead to "analysis paralysis" and why a customized, practitioner-led approach is essential. Environmental Triggers: How toxins, stress, and poor soil quality interact with your unique genetic blueprint. Whether you are struggling with unexplained infertility, chronic fatigue, or just want to optimize your "healthspan," this conversation provides a roadmap for using your DNA as a tool for empowerment rather than a source of fear.See omnystudio.com/listener for privacy information.

Carbohydrates are often blamed, feared, or oversimplified, especially after breast cancer. In this episode, Laura continues her Nutrition Myths and Truths series with an evidence-based conversation about carbohydrates. This is not about food rules. It is about understanding how carbohydrates function in the body, how they interact with metabolism, inflammation, and genetics, and what lab markers can tell us about individual response. If you missed part one of this series on red meat and understanding scientific studies, that episode provides helpful context for today's discussion. Episode highlights: Carbohydrates include vegetables, fruits, and legumes, not just bread and sugar Why blood sugar numbers alone do not reflect metabolic health How refined carbohydrates influence inflammation and gut health What research suggests about carbohydrates and cancer Why genetics and SNPs affect carbohydrate tolerance The role of insulin, triglycerides, and inflammation markers Whether grains are nutritionally essential   Let's Connect! If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

In a world where trust in traditional healthcare is collapsing, consumer genetic testing has rushed in, promising precision and control. But is your DNA test truly empowering you, or is it selling you fear dressed up as knowledge? In this critical episode, we expose the limitations and dangers of direct-to-consumer genetic reports, from the misleading focus on single SNPs (like MTHFR and FTO) to the illusion of genetic determinism. Learn why genetics loads the gun, but environment pulls the trigger, and how you can shift from being a victim of your DNA to an architect of your own health, or that of your clients.Topics discussed: - Rise of consumer genetics- Misleading fraction of your DNA- Genetics vs. Environment- Demystifying SNPs - Epigenetics'- The body's functional redundancy - Framework for coaches to evaluate genetic test quality- Fine-tuning with bloodwork and lifestyle data- Common SNPs - Ethical and privacy concerns with genetic data---------- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.metabolismschool.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- [Free] Metabolism School 101: The Video Series⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.metabolismschool.com/metabolism-101⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------Subscribe to My Youtube Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Grab a Copy of My New Book - Metabolism Made Simple⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- Stay Connected: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Youtube: SamMillerScience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: The Nutrition Coaching Collaborative Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠operations⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@sammillerscience.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

In this episode of the BiohackingVille Podcast, Rob Rene interviews Julie Alsaker, a holistic genetic specialist. They discuss the importance of understanding genetics in health, the role of methylation, and how genetic testing can provide insights into individual health needs. Julie explains her unique approach to holistic health, emphasizing the interconnectedness of genetics, emotional well-being, and environmental factors. The conversation also covers the Genius Method, a framework for personal transformation, and the significance of community in the healing process. Takeaways 1. Genetics can provide insights into individual health needs. 2. Methylation is crucial for turning genes on and off. 3. Genetic testing can clarify health issues and solutions. 4. SNPs are specific genetic variations that impact health. 5. The Genius Method focuses on identity reclamation and holistic healing. 6. Emotional healing is as important as physical health. 7. Community support enhances the healing journey. 8. Environmental factors significantly affect health outcomes. 9. Refined sugar is detrimental to health and should be avoided. 10. Holistic health integrates genetics, nutrition, and emotional well-being.

Inflammatory Bowel Disease is often explained as a “gut issue” or something managed solely with immune-suppressing medications. But the science tells a much deeper story. In this episode of Wholistic Living, we break down what actually drives IBD at the immune, genetic, and microbial level, including mechanisms that are rarely discussed in conventional care.You'll learn:Why certain genetic SNPs (like NOD2, ATG16L1, IL23R, CARD9, and FUT2) make some people far more susceptible to chronic gut inflammationHow loss of key probiotic strains and microbial metabolites can lock the immune system into an inflammatory loopThe emerging role of Epstein-Barr virus (EBV) and the gut virome in worsening disease severityWhy fungi, oral bacteria, and barrier dysfunction matter far more than most people realize How IBD progresses beyond simple flare-and-remission cyclesThis episode connects cutting-edge immunology research with real-world clinical insight to help you understand why IBD behaves the way it does, and why a one-size-fits-all approach rarely works. If you or someone you love is navigating Crohn's disease or ulcerative colitis, this conversation will change how you think about inflammation, gut health, and personalized healing.Equip Foods Grass-fed beef protein - Code: MARLAWant to work with me? email me to health@holisticspring.com

For Episode 96 of Astonishing Healthcare, Jason Barretto, our SVP of Government Programs, returns to the show for a discussion about what's happening on the health plan side of the business. As a company, we spend a lot of time talking about and showing how modern technology streamlines benefit administration workflows and overall operating efficiency, solves longstanding problems, and helps clients stay nimble to meet the intent of new regulations. Well, Jason's experience managing PBM relationships at health plans helps him - and our team - add real value when working with our clients. And, thankfully, he loves to talk about it!During this episode, we discuss:Intensifying demand for transparency (beyond just price transparency)The Inflation Reduction Act (IRA) and the implementation of Maximum Fair Prices (MFP)Slow adoption of the Medicare Prescription Payment Plan (MPPP) and how CMS is removing barriersA streamlined approach to managing Dual Special Needs Programs (D-SNPs), something Jason "wanted to solve" when he started hereA really interesting observation about the popularity of GLP-1sCMS changing its audit approach and the importance of audit readiness in 2026Related ContentHow Our Favorite New Judi® Features Aid Government ProgramsJudi Health Policy Pulse: 2025 Regulatory Roundup, the Push for PBM ReformJudi® is a Tech-Enabler – A Case StudyAH058 - Building Judi®, the Healthcare Infrastructure of the Future, with Liya LomsadzePartnership & Collaboration: Why PBMs and Health Plans Should Sync on Regulatory Change ManagementFor more information about Capital Rx and this episode, please visit Judi Health - Insights.

Why Women Are More Vulnerable—and What You Can Do ClinicallyCould histamine intolerance be the hidden driver behind your patient's anxiety, bloating, headaches, or skin flares? In this episode, nutritionist and epigenetics expert Zelda Graham breaks down the complex interplay between histamine, methylation dysfunction, gut health, and hormonal imbalances—especially in women.You'll gain critical insights into the role of DAO and HNMT enzymes, estrogen's impact on histamine load, and why symptoms often worsen during ovulation and perimenopause.Zelda also shares clinical strategies to identify and address root causes like mould exposure, gut dysbiosis, and methylation SNPS—plus targeted therapies using nutrients like quercetin, NAC, liposomal glutathione, and calcium D-glucarate.This episode is essential listening for practitioners managing complex, multisystem female presentations—from hormone imbalances to unresolved histamine-related inflammation.Connect with Zelda: Website: www.byronhealthandnutrition.comShownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.auFollow us on SocialsInstagram: DesignsforhealthausFacebook: DesignsforhealthausDISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your healthShownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au Follow us on Socials Instagram: Designsforhealthaus Facebook: Designsforhealthaus DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health

How can commercial producers use breeding values without recording full pedigrees? This week, Mark chats with Carel Teseling, Chief Operating Officer at Angus Australia, to find out. Carel's career has taken him from South Africa's regional performance recording programs to 14 years of developing genetic tools for Angus Australia, a decade leading Australian Wagyu Association's genetics, and now back to Angus again, giving him unique insight into what actually works for producers across different systems and breeds.Carel begins by sharing the story behind South Africa's groundbreaking work in livestock genetics during the 1990s, as well as his early days tackling genetic conditions in Angus, and his time at the Australian Wagyu Association.After 10 years at the Australian Wagyu Association, Carel returned to Angus Australia in 2025 as Chief Operating Officer, where he's overseeing the parallel running of the trans-Tasman (TACE) analysis and Angus's new internal analysis. He explains how the internal system has been in development for almost five years, includes new traits like immune competence and body condition, and uses different methodological approaches such as avoiding pre-adjustments on carcass data. Angus Australia is letting breeders compare both systems to see how they re-rank animals. Carel explains that while there will be some re-ranking, both point in the same direction and will still guide breeders toward genetic improvement.Carel and Mark also coverCommercial breeding strategiesThe value of female data in maternal breedsHow to identify and cull poor-performing damsWhy commercial producers should pay attention to breeding values even without recording full pedigrees.----For more information on our fundraising efforts for the 'Cure Brain Cancer Foundation' visit this link:https://fundraise.curebraincancer.org.au/fundraisers/markferguson/twentysix2000Head Shepherd is brought to you by neXtgen Agri International Limited. We help livestock farmers get the most out of the genetics they farm with. Get in touch with us if you would like to hear more about how we can help you do what you do best: info@nextgenagri.com.Thanks to our sponsors at MSD Animal Health and Allflex, Heiniger Australia and New Zealand, and ProWay Livestock Equipment. Please consider them when making product choices, as they are instrumental in enabling us to bring you this podcast each week.Check out the MSD range HERE Check out Allflex products HERE Check out Heiniger's product range HERE Check out ProWay's product range HERE

In this holiday special, Jason and Jeff wrap up 2025 by reviewing the year's biggest stories—from the AI boom to inflation and trade wars. They discuss whether the AI narrative is showing any cracks and debate which sectors might dominate in 2026, with Jason making a case for homebuilders and Jeff eyeing the energy sector. The hosts also reveal the simplified rules for the 2026 Investing Unscripted Portfolio Contest, inviting listeners to submit their "buy and hold" picks for charity. Finally, they share their "YOLO" picks and confess what they got wrong in 2025.01:25 Upcoming Contest Announcement02:00 2025 Year in Review05:47 AI Dominance and Market Trends13:08 Stock Picks for 202618:19 Sector Predictions for 202623:25 AI and Renewable Energy: The China Factor24:53 Reflecting on 2025: Biggest Misjudgments27:39 Lemonade's Unexpected Success30:48 Top Performing Stocks of 2025: Predictions for 202634:47 Robinhood's Race Against Time37:30 2026 Stock Contest: Rules and Guidelines44:29 Wrapping Up: Final Thoughts and Holiday WishesCompanies mentioned: GOOGL, ENPH, LMND, MU, NEM, NVDA, PLTR, HOOD, STX, SNPS, WBD, WDC*****************************************Join our PatreonSubscribe to our portfolio on Savvy Trader *****************************************Email: investingunscripted@gmail.comTwitter: @InvestingPodCheck out our YouTube channel for more content: ******************************************To get 15% off any paid plan at fiscal.ai, visit https://fiscal.ai/unscripted******************************************Listen to the Chit Chat Stocks Podcast for discussions on stocks, financial markets, super investors, and more. Follow the show on Spotify, Apple Podcasts, or YouTube******************************************The Smattering Six2025 Portfolio Contest2024 Portfolio Contest2023 Portfolio Contest

A DNA profile is a unique genetic fingerprint derived from an individual's DNA (deoxyribonucleic acid). DNA is the fundamental genetic material found in the cells of all living organisms, and it carries the instructions that determine our physical characteristics and biological traits.A DNA profile is created by analyzing specific regions of an individual's DNA known as short tandem repeats (STRs) or single nucleotide polymorphisms (SNPs). These regions exhibit variations between individuals, making them useful for identification purposes. DNA profiling involves extracting DNA from a biological sample, such as blood, saliva, hair, or semen, and then amplifying and analyzing the specific DNA regions of interest.Law enforcement agencies use DNA profiling in several ways:Criminal Investigations: When biological evidence is found at a crime scene, such as bloodstains or hair, DNA profiling can be performed to create a DNA profile from the sample. This profile can then be compared to profiles in DNA databases or against known suspects to identify or exclude potential perpetrators.Missing Persons and Unidentified Remains: DNA profiling plays a crucial role in identifying missing persons and unidentified remains. By comparing DNA profiles from unidentified remains to profiles of missing individuals or their relatives, law enforcement can establish familial relationships or make direct identifications.Cold Case Investigations: In cold cases, where the investigation has gone unresolved for an extended period, DNA profiling can be used to reexamine evidence and potentially link it to a known individual or identify new suspects.Forensic Intelligence: DNA profiles obtained from crime scenes can be stored in DNA databases, such as CODIS (Combined DNA Index System), which allows law enforcement agencies to compare profiles from different cases. This can help link previously unrelated crimes and provide leads for investigations.In this episode, we take a look at the new claims by Bryan Kohberger's legal team that 3 other unknown male DNA profiles were found at the crime scene and what it might mean moving forward.(commercial at 8:30)to contact me:bobbycapucci@protonmail.comsource:Bryan Kohberger claims DNA from three other men found at scene of Idaho murders | The IndependentBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.

Oracle (ORCL) weighed on markets Thursday morning but Diane King Hall turns to stocks seeing strength. Synopsys (SNPS) added muscle to the tech trade with an earnings beat and strong 2026 guidance that boosted bullish expectations from analysts. Piper Sandler hiked its price target on Alphabet (GOOGL) on the thesis Gemini will accelerate its A.I. reach. Diane then turns to the healthcare space where Eli Lilly (LLY) moved higher on positive retatrutide weight-loss drug trial results. ======== Schwab Network ========Empowering every investor and trader, every market day.Options involve risks and are not suitable for all investors. Before trading, read the Options Disclosure Document. http://bit.ly/2v9tH6DSubscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Struggling to understand why someone's metabolic health isn't improving despite clean labs and healthy habits? The missing piece might be written in their DNA. In this episode of ReInvent Healthcare, we uncover how key genetic variants (SNPs) can help you identify hidden metabolic risks and choose the right lab tests to confirm them.Discover how to combine genetic data with functional testing, and learn how to personalize your interventions with surgical precision.What's Inside This Episode?What metabolic health really means and where it goes wrongThe SNPs linked to obesity, insulin resistance, and energy dysregulationWhy normal labs can be misleading without a genetic lensHow to pair key SNPs with targeted lab tests to get clearer answersReal-world examples of using DNA to uncover hidden dysfunctionWhen to test beyond TSH and lipid panels and what to order insteadThe one genetic insight that could change your whole approach to weight loss and blood sugarResources and Links:Download our FREE Guide to Using Genetic Testing to Optimize Patient OutcomesJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes here

Futures turned to the downside ahead of Monday's trading session after a rally bolstered markets throughout Thanksgiving week. Alex Coffey talks about the market strength happening both above and under the surface. As for macro movers, Kevin Hassett is being seen as President Trump's favorable pick for Fed chair once Jerome Powell's term ends. Alex also touches on stock moves in Synopsys (SNPS) after Nvidia (NVDA) said it will invest $2 billion into the company. ======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

Dr. Pedro Barata and Dr. Aditya Bagrodia discuss the evolving landscape of testicular cancer survivorship, the impact of treatment-related complications, and management strategies to optimize long-term outcomes and quality of life. TRANSCRIPT:  Dr. Pedro Barata: Hello and welcome to By the Book, a podcast series from ASCO that features engaging conversations between editors and authors of the ASCO Educational Book. I'm Dr. Pedro Barata. I'm a medical oncologist at University Hospitals Seidman Cancer Center and associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. We all know that testicular cancer is a rare but highly curable malignancy that mainly affects young men. Multimodal advances in therapy have resulted in excellent cancer specific survival, but testicular cancer survivors face significant long term treatment related toxicities which affect their quality of life and require surveillance and management. With that, I'm very happy today to be joined by Dr. Aditya Bagrodia, a urologic oncologist, professor, and the GU Disease Team lead at UC San Diego[KI1]  Health, and also the lead author of the recently published paper in the ASCO Educational Book titled, "Key Updates in Testicular Cancer: Optimizing Survivorship and Survival." And he's also the host of the world-renowned BackTable Urology Podcast. Dr. Bagrodia, I'm so happy that you're joining us today. Welcome. Dr. Aditya Bagrodia: Thanks, Pedro. Absolutely a pleasure to be here. Really appreciate the opportunity. Dr. Pedro Barata: Absolutely.  So, just to say that our full disclosures are available in the transcript of this episode.  Let's get things started. I'm really excited to talk about this. I'm biased, I do treat testicular cancer among other GU malignancies and so it's a really, really important topic that we face every day, right? Fortunately, for most of these patients, we're able to cure them. But it always comes up the question, "What now? You know, scans, management, cardio oncology, what survivorship programs we have in place? Are we addressing the different survivorship piece, psychology, fertility, et cetera?" So, we'll try to capture all of that today. Aditya, congrats again, you did a fantastic job putting together the insights and thoughts and what we know today about this important topic. And so, let's get focused specifically about what happens when patients get cured. So, many of us, in many centers, were fortunate enough to have these survivorship programs together, but I find that sometimes from talking to colleagues, they're not exactly the same thing and they don't mean the same thing to different people, to different institutions, right? So, first things first. What do you tell a patient perhaps when they ask you, "What can happen to me now that I'm done with treatment for testicular cancer?" Whether it's chemotherapy or just surgery or even radiation therapy? "So, what about the long term? What should I expect, Doctor, that might happen to me in the long run?" Dr. Aditya Bagrodia: Totally. I mean, I think that question's really front and center, Pedro, and really appreciate you all highlighting this topic. It was an absolute honor to work with true thought leaders and the survivorship bit of it is front and center, in my opinion. It's really the focus, you know, we, generally speaking should be able to cure these young men, but it's the 10, 15, 20 years down the way that they're going to largely contend with. The conversation really begins at diagnosis, pre-education. Fortunately, the bulk of patients that present are those with stage one disease, and even very basic things like before orchiectomy, talking about a prosthetic; we know that that can impact body image and self esteem, whether or not they decide to receive it or not. Actually, just being offered a prosthetic is important and this is something, you know, for any urologist, it's kind of critical. To discussing fertility elements to this, taking your time to examine the contralateral testicle, ask about fertility problems, issues, concerns, offer sperm banking, even in the context of a completely normal contralateral testicle, I think these things are quite important.  So if it's somebody with stage one disease, you know, without going too far down discussing adjuvant therapy and so forth, I will start the conversation with, "You know, the testes do largely two things. They make testosterone and they make sperm." By and large, patients are going to be able to have acceptable levels of testosterone, adequate sperm parameters to maintain kind of a normal gonadal state and to naturally conceive, should that be something they're interested in. However, there's still going to be, depending on what resource you look at, somewhere in the order of 10-30% that are going to have issues. Where I think for the stage one patients, it's really incumbent upon us is actually to not wait for them to discuss their concerns, particularly with testosterone, which many times can be a little bit vague, but to proactively ask about it every time. Libido, erectile quality, muscle mass maintenance, energy, fatigue. All of these are kind of associated symptoms of hypogonadism. But for a lot of kids 18-20 years old, it's going to be something insidious that they don't think about. So, for the stage one patients, it absolutely starts with gonadal function. If they are stage two getting surgery, I think the counseling really needs to center around a possibility for ejaculatory dysfunction. Now, for a chemotherapy-naive, nerve-sparing RPLND, generally these days we should be able to preserve ejaculatory function at high volume centers, but you still want to bring that up and again kind of touch base on thinking about sperm banking and so forth before the operation, scars, those are things I think worth talking about, small risk of ascites. Then, I think the intensity of potential long term adverse effects really ramps up when we're talking about systemic therapy, chemotherapy. And then there's of course some radiation therapy specific elements that come up. So, for the chemotherapy bits of it, I really think this is going to be something that can be a complete multi-system affected intervention. So, anxiety, depression, our group has actually shown using some population resources that even suicidality can be increased among patients that have been treated for germ cell tumor. You know, really from the top down, tinnitus, hearing changes, those are things that we need to ask about at every appointment. Neuropathy, sexual health, that we kind of talked about, including ED (erectile dysfunction), vertigo, dizziness, Raynaud's phenomenon, these are kind of more the symptoms that I think we need to inquire about every time. And what we do here and I think at a lot of survivorship programs is use kind of a battery of validated instruments, germ cell tumor specific, platinum treated patient specific. So we use a combination of EORTC questions and PROMIS questions, which actually serves as like a review of systems for the patient, also as a research element. We review that and then depending on what might be going on, we can dig into that further, get them over to colleagues in audiology or psychology, et cetera.  And then of course, screening for the hypertension, hyperlipidemia, metabolic syndrome with basically you or myself or somebody kind of like us serving, many times it's the role of the PCP, just making sure we're checking out, you know, CBC, CMP, et cetera, lipid parameters to screen for those kind of cardiac associated issues along with secondary malignancies. Dr. Pedro Barata: So that's super comprehensive and thorough. Thank you so much. Actually, I love how you break it down in a simple way. Two functions of the testes, produce testosterone and then, you know, the problem related to that is the hypogonadism, and then the second, as you mentioned, produce sperm and of course related to the fertility issues with that.  So, let's start with the first one that you mentioned. So, you do cite that in your paper, around 5-10% of men end up getting, developing hypogonadism, maybe clinical when they present with symptoms, maybe subclinical. So, I'm wondering, for our audience, what kind of recommendations we would give for addressing that or kind of thinking of that? How often are you ordering those tests? And then, when you're thinking about testosterone replacement therapy, is that something you do immediately or are there any guidelines into context that? How do you approach that? Dr. Aditya Bagrodia: So, just a bit more on digging into it even in terms of the questions to ask, you know, "Do you have any decrease in sexual drive? Any erectile dysfunction? Are your morning erections still taking place? Has the ejaculate volume changed? Physically, muscle mass, strength? Have you been putting on weight? Have you noticed increase in body fat?" And sometimes this is complicated because there's some anxiety that comes along with a cancer diagnosis when you're 20, 30 years old, multifactorial, hair loss, hot flashes, irritability. Sometimes they'll, you know, literally they'll say, "You know, my significant other or partners noticed that I'm really just a little bit labile." So I think, you know, there's the symptoms and then checking, usually kind of a gonadal panel, FSH, LH, free and total testosterone, sex hormone binding globulin, that's going to be typically pretty comprehensive. So if you've got symptoms plus some laboratory work, and ideally that pre-orchiectomy testosterone gives you some delta. If they started out at an 800, 900, now they're 400, that might be a big change for them. And then, when you talk about TRT (Testosterone Replacement Therapy) recommendations, you know, Pedro, yourself, myself, we're kind of lucky to be at academic centers and we've got men's health colleagues that are ultra experts, but at a high level, I would say that a lot of the TRT options center around fertility goals. Exogenous testosterone treats the low T, but it does suppress gonadal function, including spermatogenesis. So if that's not a priority, they can just get TRT. It should be done under the care of a urologist, a men's health, an endocrinologist, where we're checking liver chemistries and CBCs and a PSA and so forth. If they're interested in fertility preservation, then I would say engaging an endocrinologist, men's health expert is important. There's medications even like hCG, Clomid, which works centrally and stimulate the gonadal access. Niche scenarios where they might want standard TRT now, and then down the way, 5, 7 years, they're thinking about coming off of that for fertility purposes, I think that's really where you want to have an expert involved because there's quite a bit of nuance there in recovery of actual spermatogenesis and so forth.  To kind of summarize, you got to ask about it. Checking it is, is not overly complicated. We do a baseline pre-orchiectomy and at least once annually, you can tag it in with the tumor markers, so it's not an extra blood draw. And if they have symptoms of course, kind of developed, then we'll move that up in the evaluation. Dr. Pedro Barata: Got it. And you also touch base on the fertility angle, which is truly important. And I'm just curious, you know, a lot of times many of us might see one, two patients a year, right, and we forget these protocols and what we've got to do about that.  And so I'm interested to hear your thoughts about when you think about fertility, and how proactive you get. In other words, who do you refer for the fertility clinic, for a fertility preservation program? You know, do all cases despite getting through orchiectomy or just the cases that you're going to, you know you're going to seek chemotherapy at some point? What kind of selection or it depends on the chemo, like how do you do that assessment about the referral for preservation program that you might have available at UCSD? Dr. Aditya Bagrodia: Yeah, I mean I feel really fortunate to sit on the NCCN Testis Cancer Guidelines. It's in there that fertility counseling should be discussed prior to orchiectomy. So 100% bring it up. If there are risk factors, undescended testicles, previous history of fertility concerns, atrophic contralateral testicle, anything on the ultrasound like microlithiasis in the contralateral testicle, you kind of wanna get it there. And then again, there's kind of niche scenarios where you're really worried, maybe get a semen analysis and it doesn't look that good, arrange for the time of orchiectomy to have onco-testicular sperm extraction from the, quote unquote, "normal" testis parenchyma. You know, I think you have to be kind of prepared to go that route and really make sure you're doing this completely comprehensively.  So pre-orchiectomy all patients. Don't really push for it too hard if they've got a contralateral testicle, if they've had no issues having children. There's some cost associated with this, sperm banking still isn't kind of covered even in the context of men with cancer. If they've got risk factors, absolutely pre-orchiectomy. Pre-RPLND, even though the rates of ejaculatory dysfunction at a high-volume center should be low single digits, I'll still offer it. That'd be a real catastrophe if they were in that small proportion of patients and now they're going to be reliant on things like intrauterine insemination, where it becomes quite expensive.  Pre-chemo, everybody. That's basically a standard these days where it should be discussed and it's kind of amazing currently, even if you don't have an accessible men's health fertility clinic, there are actually companies, I have no vested interest, Fellow is one such company where you can actually create an account, receive a FedEx semen analysis and cryopreservation kit, send it back in, and all CLIA certified, it's based out of California. The gentleman that runs it, is a urologist and very, very bright guy who's done a lot of great stuff for testis cancer. So, even for patients that are kind of in extremis at the hospital that kind of need to get going like yesterday, we still discuss it. We've got some mechanisms in place to either have them take a semen analysis over to our Men's Health clinic or send it off to Fellow, which I think is pretty cool and that even extends to some of our younger adolescent patients where going to a clinic and providing a sample might be tricky.  So, I think bringing it up every stage, anytime there's an intervention that might be offered, orchiectomy, chemo, surgery, radiation, it's kind of incumbent on us to discuss it. Dr. Pedro Barata: Gotcha. That's super helpful. And you also touch base on another angle, which is the psychosocial angle around this. You mentioned suicidal rates, you mentioned anxiety, perhaps depression in some cases as well as chronic fatigue, not necessarily just because of the low testosterone that you can get, but also from a psychological perspective. I'm curious, what do the recommendations look like for that? Do these patients need to see a social worker or a psychologist, or do they need to answer a screening test every time they come to see us and then based on that, we kind of escalate, take the next steps according to that? Do they see a psychologist perhaps every so often? How should that be managed and addressed? Dr. Aditya Bagrodia: It's an excellent question and again, these can be rather insidious symptoms where if you don't really dig in and inquire, they can be glossed over. I mean, how easy to say, "Your markers look okay, your scans look okay. See you in six months," and keep it kind of brief. First off, I think bringing it up proactively and normalizing it, that, "This may be something that you experience. Many people do, you're not alone, there's nothing kind of wrong with you." I also think that this is an area where support groups can be incredibly useful. We host the Testicular Cancer Awareness Foundation support group here. They'll talk about chemo brain or just like a little bit of an adjustment disorder after their diagnosis. Support groups, I think are critical. As I mentioned, we have a survivorship program that's led by a combination of our med oncs, myself on the uro-onc side, as well as APPs, where we are systematically asking about essentially the whole litany of issues that may arise, including psychosocial, anxiety, depression, suicidality. And we've got a nice kind of fast path into our cancer center support services for these young men to meet with a psychologist. If that isn't going to be sufficient, they can actually see a psychiatrist to discuss medications and so forth. I do think that we've got to screen for these because, as anticipated from diagnosis, those first 2 years, we see a rise. But even 10, 15 years out, we note, compared to controls, that there is an increased level of anxiety, depression, suicidality that might not just take place at that initial acute period of diagnosis and treatment. Dr. Pedro Barata: Really well said. Super important.  So I guess if I were to put all these together, with these really amazing advances in technology, we all know AI, some of us might be more or less aware of biomarkers coming up, including microRNA for example, and others, like as I think of all these potential long term complications for these patients, look at the future, I guess, can we use this as a way to deescalate treatment where it's not really necessary, as a way to actually prevent some of these complications? Like, how do we see where we're heading? As we manage testicular cancer, let's say, within the next 5 or 10 years, do you think there's something coming up that's going to be different from what we're doing things today? Dr. Aditya Bagrodia: Totally. I mean, I think it's as exciting as a time as there's ever been, you know, maybe notwithstanding circa 1970s when platinum was discovered. So microRNAs, which you mentioned, you know, there's a new candidate biomarker, microRNA-371. We are super excited here at UCSD. We actually have it CLIA-certified available in our lab and are ordering these tests for patients kind of in their acute stage, you know, stage one and surveillance, stage two, post-RPLND, receiving chemotherapy. And essentially this is a universal germ cell tumor specific biomarker, except for teratoma, suffice it to say 90% sensitive and specific. And I think it's going to change the way that we diagnose and manage patients. You know, pre-orchiectomy, that's pretty straightforward. Post-orchiectomy, maybe we can really decrease the number of CT scans that are done. Maybe we can identify those patients that basically have occult disease where we can intervene early, either with RPLND or single cycle chemo. Post-RPLND, identify the patients who are at higher risk of relapse that may benefit from some adjuvant therapy. In the advanced setting, look at marker decline for patients in addition to standard tumor markers. Can we modulate their systemic therapy?  So, the international interest is largely on modifying things. There's really cool clinical trials that we have for stage one patients, that treatment would be prescribed based on a post-orchiectomy microRNA. I think the microRNAs are really exciting. Teratoma remains an outstanding question. I think this is where maybe ctDNA, perhaps some radiomics and advanced imaging processing and incorporating AI may allow us to safely avoid a lot of these post-chemo RPLNDs. And then identification using SNPs and so forth of who might be most susceptible to some of the cardiac toxicity, autotoxicity and personalizing things in that way as well. Dr. Pedro Barata: Super exciting, right, what's about to come? And I agree with you, I think it's going to change dramatically how we manage this disease.  This has been a pleasure sitting down with you. I guess before letting you go, anything else you'd like to add before we wrap it up? Dr. Aditya Bagrodia: Yeah, first off, again, just want to thank you and ASCO for the opportunity. And it's easy enough to, I think, approach a patient with the testicular germ cell tumor as, "This is an easy case. We're just going to do whatever we've done. Go to the guidelines that says do X, Y, or Z." But there's so much more nuance to it than that. Getting it done perfectly, I think, is mandatory. Whatever we do is an impact on them for the next 50, 60, 70 years of their life. And I found the germ cell tumor community, people are really passionate about it. If you're ever uncertain, there's experts throughout the country and internationally. Ask somebody before you do something that you can't undo. I think we owe it to them to get it perfect so that we can really maximize the survivorship and the survival like we've been talking about. Dr. Pedro Barata: Aditya, thanks for sharing your fantastic insights with us on this podcast. Dr. Aditya Bagrodia: All right, Pedro. Fantastic. Appreciate the opportunity. Dr. Pedro Barata: And also, thank you to our listeners for your time today. I actually encourage you to check out Dr. Bagrodia's article in the 2025 ASCO Educational Book. We'll post a link to the paper in the show notes. Remember, it's free access online, and you can actually download it as well as a PDF. You can also find on the website a wealth of other great papers from the ASCO Educational Book on key advances and novel approaches that are shaping modern oncology.  So with that, thank you everyone. Thank you, Aditya, one more time, for joining us. Thank you, have a good day. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:         Dr. Pedro Barata  @PBarataMD   Dr. Aditya Bagrodia @AdityaBagrodia Follow ASCO on social media:         @ASCO on X (formerly Twitter)         ASCO on Bluesky        ASCO on Facebook         ASCO on LinkedIn         Disclosures:      Dr. Pedro Barata:  Stock and Other Ownership Interests: Luminate Medical  Honoraria: UroToday  Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon  Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas  Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck   Dr. Aditya Bagrodia: Consulting or Advisory Role: Veracyte, Ferring  

I bet you thought it was ENTIRELY about the carbs you were eating that were responsible for your weight gain, or slide into mild cognitive impairment.Well, you're not entirely wrong, however, having lots of carbs puts an increased demand on your ability use and produce choline. High carbs are one of the reasons for the choline deficiency, the other reason is that some people 25 - 40+ percent are limited in their abilty to use and manufacture choline (from Bile, to acetyl choline a vital neurotransmitter, and more). Having high carbs (carbs in general), not consuming enough choline (egg yolks and liver) and having specific SNPs (single nuclear polymorphisms) that predispose you to not being able to use choline well, or at all, puts you unequivocally at risk for cognitive impairment, dementia, and NAFD, if not obesity as well.The GOOD NEW is that it is correctable without medications through dietary changes.I kid you not.

Are you intrigued by the Naturally Nourished Academy but not sure you if make the cut? Are you passionate about food-as-medicine but unclear on how to use it in a career or how to bridge the gap of passion and expertise? In this part two episode, we go deeper into our transformative 12-week Functional Nutrition Mentorship Program, designed to help practitioners and passionate learners elevate their clinical skills, confidence, and impact. In this second installment, we walk through Weeks 7–12 of the curriculum, covering hormones, neurotransmitters, toxins, and how you will learn to address complex neurological and metabolic cases. You'll hear more participant testimonies on their game-changing experiences and start to see how our program may be the one thing you need to transform your vision into a reality! We also dig into salivary, blood, and urinary metabolites, genetic SNPs, and toxicology panels. In this episode we emphasize the scope and range of participants where you may fit as a wellness coach digging into navigating elimination diets while growing into mastering leaky gut or as a functional medicine practitioner now equipped for nuance of biochemical pathways and targeted nutrient support. No matter what we will empower you with how to expand your career with food-as-medicine and strategic supplementation.  Whether you're a dietitian, health coach, or simply obsessed with functional nutrition, this episode offers a behind-the-scenes look at how Naturally Nourished Academy helps practitioners build confidence, sharpen critical thinking, and create real transformation for their clients. What is Naturally Nourished Academy? Who is this Program for?  Questions from listeners Understanding scope of practice and liability Curriculum Walkthrough Week 7-12Highlights Understanding Hormones Hormonal shifts with the menstrual cycle and impact Navigating DUTCH and Labrix hormone labs The stress-hormone connection Understanding the HPA-axis Nutrient deficiency and cravings Unpacking stubborn metabolism in complex cases Learning how to get your client into parasympathetic balance Mastering the Detox process with food and supplements SNPs and Epigenetics How to make food-as-medicine a reality? Growing your vision into a successful business Are you ready to take your knowledge of functional nutrition to the next level? Whether you're a health coach, registered dietitian, nutritionist, medical professional, or someone deeply passionate about using food as medicine, our 12-week mentorship program is designed to transform the way you approach health and healing. This immersive mentorship experience provides: Weekly 60-minute + 90-minute live classes led by experienced functional nutrition experts Ali Miller RD LD CDE & Becki Yoo MS RD LD Hands-on learning through weekly case studies, lab reviews, and protocol development with real time feedback Real-world application with practical assignments that you can translate directly into your own clinical practice such as recipe creation, research projects and marketing materials A supportive community of like-minded professionals to grow and learn with Personalized mentorship to help you refine your approach and build confidence Access to a private Slack channel to ask questions, collaborate and pick Ali & Becki's brains between classes Early enrollment is encouraged and we are now live! We understand this is a significant commitment, both financially and logistically so we're giving you plenty of time to plan and prepare to make the most of our program. Naturally Nourished Academy launches February 4th and our program runs through May 1st 2026.   Join Here   Sponsors for this episode:  This episode is sponsored by FOND Bone Broth, your sous chef in a jar. FOND's bone broths and tallows are produced in small batches with premium ingredients from verified regenerative ranches. Their ingredients are synergistically paired for maximum absorption, nutritional benefit, and flavor. Use code ALIMILLERRD to save at https://fondbonebroth.com/ALIMILLERRD.   

A DNA profile is a unique genetic fingerprint derived from an individual's DNA (deoxyribonucleic acid). DNA is the fundamental genetic material found in the cells of all living organisms, and it carries the instructions that determine our physical characteristics and biological traits.A DNA profile is created by analyzing specific regions of an individual's DNA known as short tandem repeats (STRs) or single nucleotide polymorphisms (SNPs). These regions exhibit variations between individuals, making them useful for identification purposes. DNA profiling involves extracting DNA from a biological sample, such as blood, saliva, hair, or semen, and then amplifying and analyzing the specific DNA regions of interest.Law enforcement agencies use DNA profiling in several ways:Criminal Investigations: When biological evidence is found at a crime scene, such as bloodstains or hair, DNA profiling can be performed to create a DNA profile from the sample. This profile can then be compared to profiles in DNA databases or against known suspects to identify or exclude potential perpetrators.Missing Persons and Unidentified Remains: DNA profiling plays a crucial role in identifying missing persons and unidentified remains. By comparing DNA profiles from unidentified remains to profiles of missing individuals or their relatives, law enforcement can establish familial relationships or make direct identifications.Cold Case Investigations: In cold cases, where the investigation has gone unresolved for an extended period, DNA profiling can be used to reexamine evidence and potentially link it to a known individual or identify new suspects.Forensic Intelligence: DNA profiles obtained from crime scenes can be stored in DNA databases, such as CODIS (Combined DNA Index System), which allows law enforcement agencies to compare profiles from different cases. This can help link previously unrelated crimes and provide leads for investigations.In this episode, we take a look at the new claims by Bryan Kohberger's legal team that 3 other unknown male DNA profiles were found at the crime scene and what it might mean moving forward.(commercial at 8:30)to contact me:bobbycapucci@protonmail.comsource:Bryan Kohberger claims DNA from three other men found at scene of Idaho murders | The IndependentBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.

Dr. Kendal Stewart has dedicated his life's work to uncovering root causes and tailoring individualized solutions through genetic testing, functional medicine, and integrative care. His approach emphasizes prevention as much as treatment, using lifestyle, nutrition, and nervous system support as daily fuel for better brain function. A nationally recognized expert in neuroimmune disorders— including genetic abnormalities, chronic pain, ADD/ADHD and autism spectrum conditions, he provides practical tools to regulate stress, stabilize energy, boost mental clarity, and gain overall wellness. Key Topics: - Definition of neuroimmune syndrome and how it shows interconnectedness in the brain and body - The connection between the nervous system and inflammation and insulin resistance - Auto antibodies to look at with neuroinflammation to understand the cause - How genetic SNPs play a role in neuroimmune dysfunction - The impact of GI inflammation - Individualizing the approach to healing For more info, head to drkendalstewart.com. Listen to his podcast: Coffee with Dr. Stewart Join Erin's monthly mailing list to get health tips and fresh meal plans and recipes every month: https://mailchi.mp/adde1b3a4af3/monthlysparksignup Order Erin's new book, Live Beyond Your Label, at erinbkerry.com/upcomingbook/

Welcome back to Beautifully Broken, where healing meets high performance. Today, I'm joined by Dr. Chad Yarbrough, a pioneer in genetic testing who's changing the way we think about privacy, precision, and personalized care. Dr. Chad takes us from his early days in functional medicine—watching nonverbal kids go verbal and infertility cases resolve—to building his own lab for complete data control.We dive deep into the science of SNPs, alleles, and the epigenome, and how to interpret your genetic report without panic or paralysis. Dr. Chad explains why knowledge truly is power, how to avoid being sold unnecessary supplements, and why environment and lifestyle are still the ultimate levers for gene expression. You'll also hear real-world stories of patients reversing early dementia, overcoming histamine intolerance, and reclaiming their vitality by aligning with their genetic strengths.This is a masterclass in genetic literacy, data privacy, and actionable wellness. If you've ever felt overwhelmed by health advice online, this conversation will leave you clear, empowered, and ready to take ownership of your biology. Episode Highlights [00:00] – Welcome to Beautifully Broken: why genetics is a “river of misinformation” online[02:33] – Chad's first experience with functional medicine and genetic testing in a clinic setting[04:35] – The truth behind 23andMe: data sales, privacy breaches, and what most people don't know[06:37] – How genetics acts as your “roadmap” for personalized health and lab testing[08:05] – Moving away from fear: why color-coded reports and “red” SNPs can mislead consumers[09:42] – What sets MaxGen Labs apart: owning the machines, data privacy, and quality control[12:01] – Building easy-to-use reports with clear action steps instead of selling supplements[16:04] – Genetics 101 over coffee: DNA, alleles, and how your “recipe book” shapes you[17:52] – SNPs and supplements: why you need two indications before taking anything[21:30] – The overlooked role of histamine, diet, and environment before methylation support[25:53] – Full genome vs. validated SNPs: why more data isn't always better[30:32] – Epigenetics explained: the gun, the trigger, and the safety switch of gene expression[39:06] – Pesticide and toxin sensitivity: how your genes affect environmental exposures[41:59] – Tylenol, CYP genes, and glutathione: the hidden risk in a common pain reliever[46:15] – Real-life results: from methylfolate “aha” moments to reversing early dementia[50:49] – MTHFR and beyond: when methylfolate isn't the answer and what to try instead[54:21] – The #1 lifestyle needle-mover: detoxing your environment before supplements[59:01] – What it means to be “beautifully broken” from Chad's perspective Show ResourcesMaxGen Labs: https://maxgenlabs.com/BEAUTIFULLYBROKENCode beautifullybrokenUpgrade Your WellnessBiological Blueprint Program (Freddie's custom coaching): https://www.beautifullybroken.world/biological-blueprintBeam Minerals: beamminerals.com/beautifullybroken — Code: BEAUTIFULLYBROKENLightPathLED: lightpathled.pxf.io/c/3438432/2059835/25794 — Code: beautifullybrokenSilver Biotics: https://www.silverbiotics.com — Code: BEAUTIFULLYBROKEN CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/beautifullybroken.world/) YouTube: (https://www.youtube.com/@freddiekimmel Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of The Better Life, Dr. Marianne Pinkston and guest Ray Solano, owner of PD Labs, a compounding pharmacy, explore the intricate link between gut health and neurological well-being. They discuss how an integrative approach, combining functional medicine principles with modern therapeutics, can address the root causes of mental health conditions like anxiety, depression, and ADHD. The conversation covers the impact of diet, genetics, and lifestyle on mental health, and introduces natural and compounded solutions like L-theanine, oxytocin, and BH4. Chapters 0:00 - 4:14: Introduction and the Problem with Conventional Solutions. Dr. Pinkston introduces Ray Solano and the topic of neurological problems. They discuss the rising rates of conditions like depression and ADD and argue that conventional medicine often only treats symptoms with pharmaceuticals, ignoring the root causes. 4:14 - 8:40: The Gut-Brain Connection and Inflammatory Foods. Ray and Dr. Pinkston explain the direct link between gut health and brain function, highlighting how neurotransmitters are made in the GI tract. They emphasize that inflammatory foods like gluten, processed items, and alcohol can significantly impact mental health. 8:40 - 13:28: The Role of Genetics and Foundational Treatments. The discussion shifts to the role of genetic predispositions (SNPs) and how lifestyle and diet can either turn these genes on or off. They introduce the importance of a holistic approach, viewing health as a puzzle with multiple pieces, including nutrition, exercise, sleep, and gut health. 13:28 - 19:38: Nutraceuticals and Hormonal Support. Dr. Pinkston and Ray detail natural, accessible remedies. Ray highlights L-theanine for its calming effects and introduces oxytocin, explaining its role in social bonding and mood elevation. They discuss its use as a compounded treatment for conditions like OCD and autism. 19:38 - 25:22: The Power of Compounded Pharmaceuticals. The focus returns to specific, targeted solutions. Ray explains BH4 (tetrahydrobiopterin), a pharmaceutical used to treat a specific genetic deficiency that impacts serotonin and dopamine production. They also discuss the compounding of natural thyroid medication and the importance of personalized medicine. 25:22 - 30:40: Progesterone and Metabolic Dysfunction. The conversation broadens to include hormonal balance, with Dr. Pinkston highlighting progesterone's role in sleep and anxiety. They also discuss metabolic dysfunction, the prevalence of belly fat, and its link to hormonal disruption and chronic disease. 30:40 - 34:25: Addressing ADD and Brain Inflammation. Dr. Pinkston and Ray focus on ADD and the importance of removing inflammatory foods from the diet. Ray introduces Synapsin, a compounded nasal spray containing RG3-Ginseng, as an effective tool for reducing brain inflammation associated with ADD and other neurological issues. 34:25 - 39:05: Conclusion and Final Thoughts. Dr. Pinkston and Ray encourage listeners to seek professional support for their health issues. They emphasize the value of telehealth and the growing field of longevity medicine, which aims to fix underlying problems rather than just treating symptoms. They conclude by providing contact information for their respective websites and podcasts. Visit my website: https://www.drpbetterlife.com/ Connect with me on social media:https://www.facebook.com/pinkston4lifehttps://instagram.com/drmariannepinkstonhttps://www.linkedin.com/in/marianne-pinkston-md-857ba069https://twitter.com/pinkston4lifehttps://www.tiktok.com/@drmariannepinkston See omnystudio.com/listener for privacy information.

Lindsey Strong joins Brittany to decode how genetics, epigenetics, and key SNPs (think MTHFR, COMT, CYPs, nitric oxide) shape women's hormones, stress, fertility, and recovery - and when peptides might actually help (or not) if you're TTC, pregnant, or breastfeeding.  We break down how to read a genetics report without fear, why no one has “perfect genes,” and how to translate SNPs into food, lifestyle, and supplement strategy.  If you're a woman ready to turn your DNA, hormones, and daily habits into a simple, evidence-informed plan - for steadier energy, better cycles, smarter fertility/pregnancy/breastfeeding choices, smoother perimenopause, and clarity on when (or if) peptides make sense - this episode is for you. WE TALK ABOUT:  08:00 - Genetics & women's health basics and why “good/bad genes” is a myth 09:10 - How to read DNA reports; greens, yellows, reds as action guides 15:40 - Why many women's symptoms are “cellular dysfunction,” not a tidy diagnosis 27:20 - Cortisol wiring: ACE variants + the “golden” COMT genotype nuance 37:10 - Nitric oxide: Circulation, energy, libido; breath-of-fire and beets 41:40 - Choline at midlife, cognition, lipids; prenatal relevance too 47:10 - Envirotoxins, UGT/glucuronidation, calcium-D-glucarate, and sauna vs supplements 50:00 - Peptides 101 + safety nuance for pregnancy & breastfeeding 55:20 - Favorites: GLP-1/“tirzepatide,” MOTS-C, SS-31, Epitalon for receptors/telomeres 59:00 - How to work with a practitioner; testing + peptide education options SPONSORS: CaloCurb (get 10% OFF) is my go-to, 100% plant-based alternative to Ozempic—helping you feel full sooner, snack less, and finally trust your body again without needles, drugs, or yo-yo diets. Reset stress on demand with Pulsetto (code: BIOHACKINGBRITTANY) - a neck-worn vagus-nerve stim that calms stress in ~4 minutes so you sleep better and feel calmer. RESOURCES: Trying to conceive? Join my Baby Steps Course to optimize your fertility with biohacking. Free gift: Download my hormone-balancing, fertility-boosting chocolate recipe. Explore my luxury retreats and wellness events for women. Shop my faves: Check out my Amazon storefront for wellness essentials. Lindsey Strong's website and Instagram LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

AUTSIM - What is a potential ROOT CAUSE of Autism? Can it be helped? What I see again and again is an inability to detox caused by failures in the Transsulfuration Pathway. This is your pathway that converts homocysteine to glutathione. If you have MTHFR or 16 other Gene SNPs, you will have problems with this pathway. In little children with these SNPs, when exposed to high levels of toxins, such a mercury found in certain vaccines, or even acetaminophen (which drastically decreases glutathione levels), they will not be able to detox these toxins fast enough. They have MAJOR inflammatory responses that may cause permanent damage. Functional Glutathione and the balancing of your methylation is the ONLY way to help and prevent it. Take a listen. Reach to my office with any questions: 801-796-7667 or info@danpursermd.com

Retail sales are still surprisingly strong Although the labor market has been softening and consumers say they are worried about inflation, people are still spending money. August retail sales were up 5% compared to last year and if the annual decline of 0.7% in gasoline stations was excluded, sales would have increased 5.5% compared to last August. Strength was broad based in the report and outside of gasoline stations the only other major categories that saw declines were department stores where sales were down 1% and building material & garden equipment & supplies dealers, which fell 2.3%. Non-store retailers continued to be a dominant category as sales climbed 10.1% and food services and drinking places still saw impressive growth of 6.5%. It's because of reports like this that I worry the Fed may make a mistake if they cut rates too quickly. If they overstep, they run the risk of overheating the economy and putting added pressure on inflation.    Are quarterly reports necessary for public companies? President Trump floated the idea of switching company reports from quarterly to semiannual. It appears Trump believes this will help companies focus more on the long-term business performance rather than fixating on short-term quarterly numbers. There's also hope this will save time and money for public corporations. The SEC acknowledged they are actively looking into the plan as a spokesperson for the agency stated, "At President Trump's request, Chairman [Paul] Atkins and the SEC is prioritizing this proposal to further eliminate unnecessary regulatory burdens on companies." Being a long-term investor, I can see the benefits of changing this requirement as one quarter should not dictate your decision on whether you should buy, sell, or hold a business. Ultimately, a change like this wouldn't have a real impact on my investment philosophy and if this enabled companies to focus more on the long term and helps with costs, I would be in favor of giving companies the option to make this switch. In terms of the long-term focus, both Jamie Dimon and Warren Buffett have spoken out against not necessarily the quarterly reports, but the quarterly guidance. In a 2018 op-ed piece for the Wall Street Journal, the pair said, “In our experience, quarterly earnings guidance often leads to an unhealthy focus on short-term profits at the expense of long-term strategy, growth and sustainability.” As for the regulatory burden, I'm sure there is hope this would help entice companies to come public. There has been a huge shift in companies staying private longer and I do believe the compliance piece deters some from coming public. I'm sure there are other reasons for staying private, including control and other liquidity avenues that weren't as prominent years ago. Nonetheless, it is concerning that the number of publicly listed companies in the U.S. has fallen from more than 7,000 in 1996 to around 4,000 today.    Is your financial advisor "quiet retiring"? You may not completely understand what “quiet retiring” means, but a few years ago, my son Chase and I were on the Dr. Phil Show because they were doing an episode on what they called “quit quitting”. Chase and I were on the pro side for business and working hard, while the other side essentially felt they should still get paid the same amount and not work hard. So, I have coined the phrase, “quiet retiring”. I have been seeing this happen in the financial service industry, especially considering the fact that the average US financial advisor is 56 years old. I have noticed more of them feel they deserve to play more golf or travel more than the average person since they seem to be in retirement mode. They are not telling their clients this and they have their admin staff handle most of the routine details so you, the client, really don't know that they are not working that much behind the scenes. Hence the term "quiet retiring". Something you definitely should find out is how much your financial advisor is working? Especially if they're in their mid to late 50s because you may not have the person with the most experience watching your investments. This is very important when it comes to preparing for and weathering through difficult times. If your financial advisor is talking about retiring in the near future, be sure to understand fully what the succession plan is and who you will be dealing with. It has now been known in the industry for a few years that the average age of financial advisors is getting older and less younger advisors are coming into the industry. Be sure you understand who your financial advisor really is, who is watching your portfolio and is your investment advisor one of those that is quiet retiring?   Understand the risk of low rated bonds Some investors rightly so have started selling some stocks and they are not excited about buying more stocks at this time. As we've been saying for quite a while now, we think this is a wise move to sell some stocks that are overpriced, but unfortunately, it seems investors got used to the high returns and they have turned to low rated high-yield bonds. According to JPMorgan Chase, issuance of junk rated bonds and loans hit a monthly record of $240 billion in July. In 2025, $930 billion has been raised through junk bonds and loans. Add that to the over $1 trillion in junk bonds from 2024 and you can see that the risk for investors is starting to increase. Most investors will not buy these individual junk bonds, but they have been plowing money into the high yield mutual funds and exchange traded funds, also known as ETFs. If you dig a little bit deeper, you find some companies are raising money foolishly like a company called TransDigm Group. The company issued nearly a $5 billion high yield bond in August to pay a dividend to their shareholders. We like companies that pay dividends, but it should be from cash flow not from borrowing money that has to be paid back. Business development companies are also back in the news, and these businesses make private loans to small and midsize companies. Over the 12-month period ending in June, private loan activity increased by 33%. I have similar concerns with business development companies and private credit, which I believe will have a crash sometime in the future and cost investors more money than they anticipated. The current default rate on higher yield bonds is 4.7%, which is not bad, but it is not good either. If interest rates on the long end were to increase, which I think is a good possibility the need for debt increases. This could slow the economy and cause some of these smaller companies that have these high-yield loans to default and file bankruptcy, which means investors would lose money. It is nice to get a 10 to 20% return on your portfolio, but sometimes when things are expensive, you have to be conservative and while that may cost you some of the upside, the downside can be a lot nastier than you realize!   Financial Planning: Dealing with underwater cars About a quarter of vehicles traded in today carry negative equity, with the average shortfall around $6,500. This happens because cars depreciate quickly, and the trade-in value offered by a dealership is the lowest number you'll see—less than what you might get in a private sale, and well below the dealer's eventual resale price.  Because of this depreciation, about 40% of financed vehicles on the road carry negative equity. While it's possible to roll negative equity into a new auto loan, that often creates a deeper hole: you're financing more than the car is worth, and the new vehicle immediately begins its own depreciation cycle. Lenders may approve the loan, but the higher loan-to-value ratio can lead to higher interest rates or tighter terms. GAP insurance can be used to cover the difference between a car's actual value and what's owed in the event of a total loss, but it doesn't prevent the financial strain of trading in too early, and it comes with an extra cost. With so many vehicles underwater, the safer move for most people is to keep driving the current car until the balance catches up with its value rather than trading in and compounding the problem or bring more cash to the deal, so you don't have to finance as much.   Companies Discussed: Zillow Group, Inc (Z), Workday, Inc. (WDAY), Lyft, Inc. (LYFT) & Synopsys, Inc. (SNPS)

S&P Futures are positive this morning as the market awaits the release of the Produce Price Index ahead of the opening bell. President Trump will travel to the U.K next week (September 17–19) for a rare second state visit. Trump is actively urging the EU to impose 100% tariffs on China and India in an effort to curtail those countries purchases of Russian oil. He also signed an Executive Order targeting pharmaceutical advertising. The Supreme Court will hear oral arguments in early Nov on the Trumps tariffs. On the earning front ORCL delivered a strong report and is trading higher. After the bell today, earnings releases are expected form GME, SNPS & ORC

Synopsys (SNPS) opened Wednesday as the biggest laggard in the SPX, down over 30% after it posted weaker-than-expected earnings and guidance. Sam Vadas also mentions commentary from leadership on "expectations of deals that did not materialize" and continuous headwinds in China. The original meme stock, GameStop (GME), shows surprising earnings strength that investors rewarded with a rally. Sam later turns to Novo Nordisk (NVO) after the GLP-1 giant cut 9,000 jobs, along with Klarna's IPO expected later on Wednesday.======== Schwab Network ========Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/ About Schwab Network - https://schwabnetwork.com/about

Stocks are shrugging off September's historically volatile reputation, with S&P 500 (SPX) futures hitting a record high ahead of Wednesday's open. Kevin Green says investors are looking past small-cap lagginess and instead, focusing on the narrative around Oracle (ORCL). The company guidance cited strong demand for its cloud infrastructure, with a 77% year-over-year revenue jump, and a massive increase in its backlog of orders. However, not all tech stocks are created equal, as seen in Synopsys' (SNPS) revenue miss, which KG attributes to a drag in demand and lost deals. Meanwhile, all eyes are on the PPI inflation print, with expectations for a 0.3% month-over-month increase.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

Markets closed mixed following a lighter-than-expected PPI print and ahead of Thursday's CPI report. Oracle (ORCL) clearly led the way with a massive rally off guidance that wowed investors and analysts. Synopsys (SNPS) saw a near-opposite reaction after showing weakening guidance and concerns on China export restrictions. Klarna (KLAR) had a successful first session on public markets with investors hopeful the fintech firm can shape up its growth story. Marley Kayden takes investors through a turbulent session on Wall Street.======== Schwab Network ========Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/ About Schwab Network - https://schwabnetwork.com/about

S&P Futures are positive this morning as the market await the payroll revisions data, a downward revision of up to 1m is expected. The White House is said to be preparing a report that will be critical of BLS data gathering functions. Apple's major product launch will be a key highlight today, the event kicks off at 1:00 PM ET, with new iPhones, Apple Watches, and AirPods expected to be announced. Anglo American & Teck Resources announced a merger.  The Salesforce CEO will be presenting today at the Goldman Sachs' Communacopia & Tech event at 4:25pm. Executives from C & JPM will be presenting today at Barclays financial conference. On the earning front CASY is lower after its earnings announcement. After the bell today, earnings releases are expected form GME, SNPS & ORCL

S&P Futures are positive this morning as the latest payrolls data is increasing the odds of a 50-basis point cut at next weeks Fed meeting. Tomorrow the BLS will be announcing its revisions to the payroll data for the period of April 2024 to March 2025. This week's inflation reports could derail a large cut. President Trump is expected to meet with EU officials this week on talks aimed at ending the Ukraine Russia war, sanctions and energy policies are likely to be discussed. On Sunday, Tres Sec Bessent said he's confident that the tariffs will be upheld by the Supreme Court.  This week's sell-side calendar is busy, with today's highlights including Goldman Sachs' Communacopia & Tech event, Morgan Stanley's healthcare conference, and the Barclays financial conference, all featuring top executives sharing sector-specific and market outlooks. On the earning front CASY is releasing after the bell today and later this week ORCL, SNPS, GME, CHWY, RH, KR & ADBE are scheduled to release.

Dr. Mark Sherwood joins Dr. Gillian Lockitch to discuss the possibility of aging with strength, clarity, and intention. He explores how epigenetics, mindset, and spiritual alignment shape our health span far more than genetics alone. From hydrogen therapy and antioxidant support to biological clock testing and emotional resilience, Dr. Sherwood shares real-world tools that have helped patients reverse their biological age and regain vitality. This conversation will inspire listeners to become active participants in their own longevity journey—empowered by science, faith, and hope.  Dr. Mark Sherwood is a naturopathic doctor, best-selling author, and co-founder of the Functional Medical Institute in Tulsa, Oklahoma. With his wife, Dr. Michele Sherwood, he empowers clients around the globe to take control of their health through personalized lifestyle interventions. He is the author of The Quest for Wellness and a frequent national speaker on natural health, longevity, and epigenetics. Dr. Sherwood's approach integrates spiritual well-being, comprehensive diagnostics, and cutting-edge protocols such as molecular hydrogen therapy and glycan age testing. His mission is to help people live younger longer—body, mind, and spirit.  Timeline Summary: 0:00–2:15 – Intro: Dr. Gillian Lockitch introduces the podcast and the 2025 theme “Age is Just a Number,” focusing on biological age vs. chronological age.  2:15–3:56 – Guest Introduction: Dr. Mark Sherwood, expert in functional medicine, wellness transformation, and natural longevity.  3:56–5:33 – Defining Longevity: Focus on health span over lifespan—living pain-free, mentally sharp, and physically capable.  5:33–9:51 – Epigenetics vs. Genetics: Environment, lifestyle, and mindset strongly influence gene expression and aging.  9:51–11:59 – Dealing with Unexpected Health Challenges: Emphasizes learning and growth rather than self-pity.  11:59–15:18 – Spiritual Health: Belief in a creator; spirituality contributes to resilience and perspective.  15:18–24:06 – Innovative Longevity Protocols:  Molecular Hydrogen (water & gas) to reduce free radicals.  Carotenoids and Antioxidants (e.g., Nu Skin's scanner and products) to mitigate oxidative damage.  Internal vs. external antioxidants and key cofactors like manganese, selenium, and iron.  24:06–27:33 – Testing Strategy: Comprehensive lab work, hormone and inflammation panels, genetic SNPs, glycan profiling to assess biological age.  27:33–29:44 – Results and Success: Reversal of biological age by up to 40 years; patients gain freedom from disease and become their own health educators.  29:44–31:46 – Biological Clocks: GlycanAge (favored for modifiability and disease predictability), DunedinPACE, and Horvath Clock.  31:46–End – Final Takeaway: Hope is a key driver of wellness; mindset and belief shape outcomes.    Book a one-on-one call with Dr. Gillian Lockitch     Join the Growing Older Living Younger Community    Learn About Dr. Mark Sherwood  https://fmi.kit.com/c7e2e2b8ea  X - MarkSherwood4e IG - Drs. Mark and Michele Sherwood YouTube - Sherwood TV 

We're diving into the top functional and conventional tests to consider after the second trimester or late pregnancy loss, especially if you've been diagnosed with low AMH, high FSH, diminished ovarian reserve (DOR), or premature ovarian insufficiency (POI). If you've had a second trimester loss or late pregnancy loss after 20 weeks and been told “everything looks normal,”this episode is for you. We dive into what's often overlooked in conventional care and how a functional fertility approach can help uncover underlying imbalances that impact conception, hormone health, and pregnancy outcomes. In this episode we cover 7 categories of testing to consider after late loss especially if you have low AMH, diminished ovarian reserve, autoimmune issues, recurrent miscarriage, or unexplained infertility. You'll learn: The top clotting and thrombophilia markers to test (including Factor V Leiden and antiphospholipid antibodies) Which inflammatory and immune markers (hs-CRP, ANA, cytokines, NK cells) are often missed and why they matter How the vaginal microbiome and hidden infections like ureaplasma can cause second-trimester loss The role of chronic stress, adrenal hormones and the HPA axis in pregnancy outcomes Why a comprehensive blood chemistry panel can reveal nutrient deficiencies and hormone imbalances that are missed by conventional labs Key methylation and genetic SNPs (like MTHFR) that impact detoxification, clotting and hormone metabolism The impact of gut health and stool testing on immune tolerance, estrogen balance and inflammation We'll also explain how this whole body functional lens can guide your next steps in preconception planning, whether you're trying again naturally or preparing for IVF. This episode is for you if: You've experienced a loss after 14 weeks of pregnancy and are seeking deeper understanding and support. You want to explore both conventional and functional medicine approaches to uncover underlying causes. You're looking for practical lifestyle, testing, and healing strategies to improve future pregnancy outcomes. --- TIMESTAMPS [00:00:00] Introduction: Late term pregnancy loss overview, compassion, and what to expect in this episode [00:02:30] Functional fertility testing for late term loss thrombophilia panel, immune markers, inflammation, and infections [00:06:00] Stress hormones, nervous system support, and comprehensive blood chemistry for improving pregnancy outcomes [00:09:00] Blood sugar, insulin, and comprehensive thyroid testing in pregnancy loss [00:12:00] Genetic testing, including MTHFR mutations and the importance of body healing before conception [00:14:30] Role of gut health, infections, and estrogen metabolism in pregnancy loss --- RESOURCES

Andrew Graham likes low-beta stocks right now, encompassing names like Cisco Systems (CSCO), where he likes their innovation and a potential corporate tech cycle. He's also watching Synopsys (SNPS), which he calls “less expensive” than its peers. In energy, he likes EQT (EQT) as a natural gas play. Andrew shares his expectations around the August 1 trade deadline and the 2Q earnings season.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

Shelagh Glaser, CFO of Synopsys (SNPS), talks about the company's recent acquisition of Ansys. She believes it will make Synopsys a leading engineer for silicon design and software security. Shelagh adds that it gives the company edge to expand physical A.I. capabilities for hyperscaler and automotive customers.======== Schwab Network ========Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/ About Schwab Network - https://schwabnetwork.com/about

Genetic Testing and Stress: A New Approach to Weight LossEpisode Summary:In this episode, Dr. Ali Novitsky delves into the intricate relationship between cortisol and weight loss. As an obesity medicine doctor, she teaches about cortisol, a stress hormone, in a way that anyone can understand - and how this important chemical can significantly impact weight loss efforts.Listeners will walk away with a new understanding of how to stop battling their biology, reconnect with their bodies, and embrace a compassionate, personalized approach to long-term health.1. The Stress-Weight Loss DisconnectHow cortisol — the body's primary stress hormone — impacts fat retention, appetite, insulin resistance, and even skeletal muscle loss.Why traditional advice (eat less, move more) often fails under chronic stress conditions.2. Cortisol's Five-Fold Impact on Fat LossEnhances fat storage via lipoprotein lipase.Raises blood sugar through gluconeogenesis.Promotes insulin resistance, sabotaging metabolism.Stimulates cravings for sugary, fatty foods.Depletes muscle mass — especially under high-exertion training paired with emotional stress.3. How Stress Alters Appetite & MotivationThe biological basis behind binge-eating urges and low exercise motivation during stress.How stress-related sleep disruption increases ghrelin (hunger) and suppresses leptin (satiety).4. The Power of Genetics and PersonalizationWhy Dr. Novitsky utilizes genetic testing (e.g., Genomind) to identify cortisol-related SNPs and tailor strategies accordingly.Insight into Dr. Novitsky's own cortisol sensitivity and how it shaped her evolution.5. Mind-Body Fitness: A Holistic Training PhilosophyHow Dr. Ali moved from calorie-obsessed fitness to personalized, neuroscience-driven strength training.Why “less is more” when it comes to training under chronic stress and how to work with your nervous system, not against it.Examples of muscle-preserving success — even among clients on GLP-1 medications like her 70-year-old mother-in-law. 6. Transformational Coaching & CommunityA behind-the-scenes look at Dr. Ali's Transform program; not just a fitness plan, but a full-body reset grounded in self-compassion and personal truth.Why clients return not for new content, but for the safe, sustaining sisterhood and the life-changing mental shifts.⏱️ Timestamps:00:00:00 - Introduction and Eye Appointment00:01:09 - Cortisol Connection with Weight Loss00:02:45 - Genetic Testing and Cortisol Response00:04:10 - Typical Case Scenario00:05:37 - Understanding Cortisol's Impact00:08:06 - Cortisol and Blood Sugar Levels00:09:32 - Cortisol's Effect on Appetite00:10:48 - Skeletal Muscle Mass Loss00:12:57 - The Sleep-Cortisol Relationship00:14:40 - Strategies for Managing Stress00:17:11 - Conclusion and Program Offerings

$24 billion of free cash flow in a single quarter is no small feat. If Nvidia can keep that pace, it may actually be trading at a reasonable price. (00:21) Tim Beyers and Mary Long discuss: - Market relief about the latest in Trump's trade saga. - A rose and a thorn from Nvidia's latest report. - Another trade-related announcement that affects the semiconductor supply chain. Companies discussed: NVDA, CDNS, SNPS, SIEGY Host: Mary Long Guest: Tim Beyers Engineer: Dan Boyd Advertisements are sponsored content and provided for informational purposes only. The Motley Fool and its affiliates (collectively, "TMF") do not endorse, recommend, or verify the accuracy or completeness of the statements made within advertisements. TMF is not involved in the offer, sale, or solicitation of any securities advertised herein and makes no representations regarding the suitability, or risks associated with any investment opportunity presented. Investors should conduct their own due diligence and consult with legal, tax, and financial advisors before making any investment decisions. TMF assumes no responsibility for any losses or damages arising from this advertisement. Learn more about your ad choices. Visit megaphone.fm/adchoices

The race to quantum supremacy is on. While this future will not come tomorrow, big tech companies are building to the technology's “ChatGPT moment.” Motley Fool Senior Analyst, Asit Sharma ,joins Mary Long to discuss: - The complex problems that quantum computers could solve. - How healthcare and logistics companies benefit from ultra-fast processing. - The small players and hyperscalers building the future of quantum. Companies discussed: GOOG, GOOGL, MSFT, IBM, QBTS, AMZN, RGTI, CDNS, SNPS, IONQ Motley Fool One members can access Asit's full report, “Decoding Quantum” here: https://www.fool.com/premium/4627/coverage/2025/03/19/decoding-quantum-insights-for-investors Host: Mary Long Guest: Asit Sharma Producer: Ricky Mulvey Engineer: Rick Engdahl Learn more about your ad choices. Visit megaphone.fm/adchoices

TikTok Flat Earthers; News Items: De-extincting the Dire Wolf, What Experts Think About AI, Planned Obsolescence, VR Touch Sensory; Who's That Noisy; Your Questions and E-mails: SNPs vs Sequencing; Science or Fiction