Podcasts about Fat

Your Hormones Are Killing You: Oxytocin, FSH, and the Anti-Aging Protocol Most Doctors Ignore Your hormones are running your love life, your intuition, your longevity, and your brain, and most doctors are getting it completely wrong. Host Dave Asprey sits down with triple board-certified OBGYN Dr. Anna Cabeca to break down the clinical science of oxytocin, female pleasure, hormonal optimization, and why fixing your hormones can make your 70s the best decade of your marriage. Dr. Anna Cabeca is a triple board-certified OBGYN and fellow of gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine, with additional board certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. She is the bestselling author of The Hormone Fix, Keto-Green 16, and MenuPause, and has spent decades researching the clinical intersection of oxytocin, cortisol, estrogen, and progesterone on women's hormonal health, metabolism, and longevity. Her work on keto-green nutrition, vaginal and bladder microbiome health, and bioidentical hormone replacement has made her one of the most credentialed and clinically experienced voices in women's functional medicine practicing today. Dave and Dr. Anna break down the real pharmacology of oxytocin, including its role in muscle regeneration, cortisol suppression, mitochondrial signaling, and vagal tone optimization. They expose the toxic ingredients hiding in mainstream lubricants and vaginal hormone creams, including aspartame, parabens, and petroleum derivatives, and explain why the vaginal microbiome is a frontline organ for women's metabolism and anti-aging. They get into the neuroscience of orgasm, pineal gland activation, endogenous DMT release, and the neurochemical cascade behind peak altered states. Dr. Anna also breaks down the Women's Health Initiative disaster, the FDA's recent reversal on bioidentical hormone replacement, and why FSH is a critical and widely overlooked longevity biomarker. High post-menopausal FSH drives neuroinflammation, accelerates bone loss, and degrades brain optimization outcomes, and most physicians are not testing for it. This is essential listening for anyone serious about biohacking, longevity, anti-aging, functional medicine, human performance, brain optimization, and taking full ownership of their biology. You'll Learn: Why oxytocin functions as a regenerative hormone that rebuilds muscle, suppresses cortisol, and supports mitochondria signaling What toxic chemicals are hiding in standard lubricants and vaginal hormone creams and what to use instead How orgasm activates the pineal gland and triggers endogenous DMT release and altered neurological states Why female intuition may be directly linked to mitochondrial density concentrated in the ovaries How elevated FSH drives neuroinflammation, bone loss, and accelerated brain aging in post-menopausal women Why the FDA reversed 30 years of flawed guidance on bioidentical hormone replacement therapy How four days of sensory deprivation supercharges melatonin, oxytocin, and endogenous DMT production Why oxytocin combined with ketamine is being used clinically to break trauma patterns and rewire neural pathways How polyphenols, CoQ10, carnitine, and vagal tone training protect cardiovascular health and support longevity Why polypharma accelerates decline and what functional medicine does differently Thank you to our sponsors! - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Gatlan | Book your free consultation at www.gatlan.com/DAVE - Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Anna Cabeca, The Girlfriend Doctor, oxytocin, bioidentical hormone replacement, FSH, follicle-stimulating hormone, vaginal microbiome, Velve lubricant, Julva, Mighty Maca, cortisol suppression, pineal gland, DMT, neuroinflammation, broken heart syndrome, NT-proBNP, vagal tone, dark retreat, orgasmic meditation, Women's Health Initiative, perimenopause, postmenopause, yoni massage, oxytocin nasal spray, cabergoline, prolactin, Pitocin, CoQ10, carnitine, Arterosil, polypharma, keto-green, The Hormone Fix Resources: • Get An Exclusive Offer On Dr. Anna's Products At: dranna.com/tribe • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:37 – What Is Oxytocin? 07:38 – Clean Lube Launch 09:11 – Toxic Lube Ingredients 17:08 – Oxytocin Prescribing 18:58 – FDA Reverses HRT Warning 26:50 – Dark Retreat & DMT 32:15 – Orgasmic Meditation 42:06 – Female Intuition 46:21 – Broken Heart Syndrome 51:15 – FSH & Hormone Monitoring See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us Fan MailPeaches sits down with Marc Humbert and Cameron Garber from KORR Medical Technologies to talk VO2 max, metabolic testing, heart rate zones, fueling, recovery, and how warfighters can train smarter instead of just getting crushed.This episode breaks down what VO2 max actually measures, why oxygen consumption matters, how carbon dioxide output helps determine fat and carbohydrate burn, and why heart rate zones are only useful when they are actually individualized. Marc and Cameron explain how metabolic testing can help athletes, warfighters, pilots, and tactical professionals understand workload, caloric burn, fatigue resistance, recovery needs, and performance limitations.The crew also gets into Zone 2 cardio, why easy days need to actually be easy, how hard days should be hard enough to drive adaptation, and why constantly redlining every workout is a fast track to burnout, fatigue, and injury. They also discuss military readiness, human performance, pilot endurance, long-duration missions, rucking, carbohydrate replacement, fat adaptation, and how testing can help protect the investment the military makes in its people.Find KORR Medical Technologies:KORR.comCheck out Tasty Gains:TastyGains.comGear from ATACLETE:OnesReady.comTrain with us:OperatorTrainingSummit.comChapters:00:00 - Intro, Tasty Gains, ATACLETE, and Operator Training Summit03:17 - Meet Marc and Cameron from KORR Medical Technologies04:00 - Health, Longevity, and Staying Ready for Life07:18 - Why Metabolic Testing Matters Before People Break10:23 - Protecting the Military's Investment in People13:25 - Readiness During Service and Life After Service17:43 - What the Cardio Coach Measures19:19 - VO2 Max, Workload, and Caloric Burn21:37 - Fat vs. Carbohydrate Burn23:58 - Fueling, Recovery, and Heart Rate Zones25:12 - Individualizing Training Instead of Guessing27:03 - Why Harder Every Day Does Not Work28:52 - Zone 2, Taylor Starch, and Smarter Programming30:53 - Training You Can Actually Recover From32:00 - Why Easy Days Need to Stay Easy35:40 - Different Athletes Need Different Fueling Strategies37:28 - Pilot Endurance and Long-Duration Missions43:05 - Fatigue Resistance Testing46:12 - Honoring Heart Rate Zones and Recovery Signals48:04 - The 80/20 Training Model51:28 - Rucking, Heavy Loads, and Calorie Replacement56:35 - Who Should Use the Cardio Coach?59:47 - Military Use Cases for VO2 Testing01:02:15 - How to Find KORR Medical Technologies01:03:40 - Cutting Through Fitness Misinformation01:04:14 - Final Thoughts and Wrap-UpSupport the showJoin this channel to get access to perks: HEREBuzzsprout Subscription page:  HERERegister for our Operator Training Summit:  OperatorTrainingSummit.comFind an Air Force Recruiter: AirForce.comCollabs:Ones Ready - OnesReady.com 18A Fitness - Promo Code:  ONESREADY ATACLete - Follow the URL (no promo code):  ATACLeteDanger Close Apparel - Promo Code:  ONESREADYDFND Apparel...

Deborah Sager is the author of Your Daily Dose: Food, Faith, and Freedom, a 366-day devotional that encourages readers to break free from food addiction through the power of faith, biblical truth, and a low-carb lifestyle. Drawing from her own journey, Deborah offers daily inspiration and practical encouragement to help people find lasting freedom, deepen their relationship with God, and build healthier habits that nourish both body and soul. In this episode, Dr. Brian, Dr. Tro, and Deborah talk about… (00:00) Intro (03:51) Fat shaming and bullying in school (10:50) Deborah's past struggles with addiction to drugs, alcohol, and food (12:27) Why Deborah wrote Your Daily Dose: Food, Faith, and Freedom (13:38) Deborah's battle with Alpha-1 Antitrypsin Deficiency (16:40) The psychology of addictive behavior and how Deborah found Jesus (25:46) Deborah's roller coaster ride of a weight loss journey and how she discovered keto (29:17) Food addiction and faith (36:36) Yoyo dieting and making your diet fun and sustainable (40:26) Emotional triggers and diet (44:06) Fasting and vows (48:04) Deborah's book and Dr. Boz (52:37) How much of an impact having a positive outlook helps with lifestyle change (57:58) Advice for those struggling with addiction  (01:00:05) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Deborah Sager: Health Coaching: https://sites.google.com/view/ketopep/home Your Daily Dose: Food, Faith, and Freedom (book): https://www.amazon.com/Your-Daily-Dose-Devotional-supporting/dp/B0FHKDSP41 Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://toward.health Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://toward.health/community/

You already know something has changed - the energy crashes, the slow recovery, the brain fog that wasn't there ten years ago. Most people assume that's just aging. But it's NOT. Nobel Prize-winning research has identified a single molecule that controls how fast your body breaks down, and more importantly, exactly why yours is being destroyed faster than it's being rebuilt. The fix isn't complicated, but the order you do it in matters. In this video, Dave breaks down what this molecule is, why your body is actively working against it, and the exact protocol (diet, fasting, exercise, and supplementation) to restore it before the gap gets any wider.Thank you to our sponsors!Gatlan | Book your free consultation at www.gatlan.com/DAVEViome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – The Longevity Switch0:47 – Why Mitochondria Matter2:28 – What Mitophagy Is2:46 – How Mitophagy Works4:18 – What Shuts It Off8:54 – The Damage Compounds9:22 – How to Turn It Back On10:31 – Signal 1: Fasting11:48 – Signal 2: Exercise (REHIT)12:30 – Signal 3: Cold Exposure13:22 – Signal 4: NAD+14:29 – Signal 5: Urolithin A and SpermidineConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fish Oil Supplements And Alzheimer's-Related Decline A two-year randomized, double-blind, placebo-controlled trial led by researchers at USC tested whether 2,000 mg of DHA fish oil daily could slow Alzheimer's-related brain changes in 365 adults ages 55–80 who rarely consumed fish and had at least one Alzheimer's risk factor. Researchers confirmed the supplement reached the brain by measuring a roughly 17% increase in cerebrospinal fluid DHA after six months. Despite successfully increasing brain DHA levels, participants taking fish oil showed no significant improvements in memory, global cognitive function, or hippocampal volume compared to placebo after two years. Host Dave Asprey explains why raising a single biomarker doesn't always translate into better brain performance, why nutrition works differently inside a complete dietary pattern than as an isolated supplement, and what this study means for anyone relying on fish oil as an Alzheimer's prevention strategy. Sources: https://medicalxpress.com/news/2026-06-fish-oil-supplements-alzheimer-decline.pdf https://www.cnn.com/2026/06/18/health/omega-3-fish-oil-algae-supplement-wellness ~~ DASH Diet Showed the Strongest Link to Long-Term Brain Health Researchers from Harvard analyzed dietary data from 159,347 participants across three long-running U.S. health studies to examine how eating patterns influence cognitive aging. Participants completed dietary questionnaires every four years over several decades, allowing investigators to compare six healthy dietary patterns, including the DASH and Mediterranean diets. While all six were associated with better cognitive health later in life, adherence to the DASH diet produced the strongest association, with participants showing roughly a 40% lower risk of subjective cognitive decline and stronger performance on objective cognitive testing. The protective relationship was strongest when healthy eating habits began during midlife. Host Dave Asprey breaks down why blood sugar control, lower inflammation, and healthier blood vessels may be the real drivers behind long-term brain resilience, and why your dietary choices in your 40s and 50s may have an outsized impact on cognitive aging decades later. Sources: https://jamanetwork.com/journals/jamaneurology/article-abstract/2845466 https://www.health.harvard.edu/diet-and-nutrition/harvard-study-six-healthy-diets-linked-with-better-long-term-brain-health https://www.eurekalert.org/news-releases/1117225 ~~ Scientists Identified an Ancient Brain Circuit That Filters Distractions Johns Hopkins researchers discovered a small population of inhibitory neurons within an evolutionarily ancient brainstem region that appears to control selective attention by determining which sensory information deserves focus and which distractions should be ignored. Mice trained on visual attention tasks consistently ignored irrelevant stimuli until researchers temporarily silenced these neurons, causing even weak distractions to hijack their attention while leaving vision and movement otherwise unaffected. Similar brain circuits exist in birds, reptiles, and other vertebrates, suggesting this attentional filtering system evolved long before the modern human cortex. Host Dave Asprey explains why attention may depend on much older brain circuitry than previously believed, how this discovery could reshape our understanding of ADHD and autism, and why future therapies may target the brainstem instead of the prefrontal cortex. Sources: https://www.sciencedaily.com/releases/2026/06/260624025426.htm ~~ Nearly Half of Older Adults Improved With Age Instead of Declining A Yale-led study followed 11,340 adults age 65 and older for up to 12 years using repeated measurements of cognition and walking speed to better understand how aging changes over time. Rather than finding universal decline, researchers discovered that 45% of participants improved in either cognitive function, physical performance, or both. Nearly one-third experienced measurable cognitive improvements, while over one-quarter improved physically. Researchers also found that participants with more positive beliefs about aging were significantly more likely to improve, even after accounting for education, chronic illness, depression, and other health factors. Host Dave Asprey explores why expectations about aging may become biologically embedded, why decline is far less inevitable than conventional medicine often assumes, and how mindset may directly influence healthy longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260620100428.htm ~~ Glyphosate May Be Contributing to Antibiotic-Resistant Superbugs Researchers publishing in Frontiers in Microbiology examined 102 bacterial strains collected from hospitals, agricultural land, and protected wetlands to investigate whether glyphosate exposure contributes to multidrug antibiotic resistance. Hospital bacteria demonstrated extensive resistance to both antibiotics and glyphosate, while even bacteria living inside protected nature reserves displayed measurable glyphosate resistance despite no direct herbicide application. Genetic analysis suggested resistant bacterial strains may move between agricultural environments and hospitals through shared waterways and sediments. The researchers argue pesticide safety testing should also evaluate whether chemicals encourage antibiotic resistance, one of the world's fastest-growing public health threats. Host Dave Asprey explains why environmental toxins may have unintended effects on the human microbiome, how herbicides could influence antimicrobial resistance beyond farming, and why environmental biology increasingly belongs in conversations about human health. Sources: https://www.sciencedaily.com/releases/2026/06/260620100434.htm https://www.openaccessgovernment.org/common-weedkiller-glyphosate-linked-to-rise-in-superbugs-scientists-warn/207515/ ~~ Butterflies That Barely Age Could Unlock New Longevity Pathways Researchers from the University of Bristol found that Heliconius butterflies live dramatically longer than closely related butterfly species while aging much more slowly. In one comparison, Heliconius hewitsoni survived up to 348 days, while a closely related species lived only 14 days. Unlike most butterflies, Heliconius feed on pollen throughout adulthood, providing amino acids that help preserve muscle function and physical performance with age. However, even when pollen was removed, these butterflies still significantly outlived their relatives, suggesting evolved genetic and metabolic mechanisms also contribute to their exceptional longevity. Host Dave Asprey explores why nature continues to provide unexpected models for slowing biological aging, what scientists hope to learn from species that naturally maintain function over time, and how comparative biology may uncover entirely new pathways for extending human healthspan. Sources: https://www.sciencedaily.com/releases/2026/06/260622014302.htm ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into omega-3 supplementation and Alzheimer's prevention, nutrition strategies for preserving cognitive health, newly discovered brain circuits controlling attention, the surprising biology behind healthy aging, environmental drivers of antibiotic resistance, and what one remarkably long-lived butterfly can teach us about extending healthspan. Host Dave Asprey connects randomized clinical trials, large population studies, neuroscience discoveries, microbiology research, and evolutionary biology into practical frameworks for improving brain performance, resilience, and longevity. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: fish oil Alzheimer's study, DHA supplements memory, omega-3 brain health, DASH diet cognition, dementia prevention diet, cognitive decline nutrition, selective attention brainstem, focus neuroscience, ADHD brain research, positive aging beliefs, healthy aging study, cognitive improvement older adults, glyphosate antibiotic resistance, superbugs glyphosate, environmental toxins microbiome, butterfly longevity research, Heliconius aging, longevity science, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:18 – Story #1 Fish Oil 02:31 – Story #2 DASH Diet 03:49 – Story #3 Brain Stem Attention Filter 05:59 – Story #4 Cognitive Decline Lies 08:24 – Story #5 Glyphosate 10:16 – Story #6 Butterfly Lifespan Research 12:16 – Biohacking Criticism Response See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most energy drinks trade your long-term health for a short-term jolt. This episode breaks down a smarter approach to energy, one that builds mitochondria function, supports gut health, stabilizes mood, and helps you sleep better at night, all without the crash -Get 15% off your next order at: https://getmte.com/dave Host Dave Asprey sits down with Jeff Boyd, founder and chairman of MTE (More Than Energy), the caffeine-free energy drink built around adaptogens, nootropics, and prebiotics that delivers what Boyd calls "energy that loves you back." Before launching MTE, Jeff spent 15 years as President and co-owner of Luggage Free, scaling the company to operations in over 100 countries before selling it in 2019. He brings the operational discipline of a veteran entrepreneur and the personal conviction of someone who built the energy product he actually wanted to exist. Dave and Jeff get into the full science and strategy behind MTE's ingredient stack, including paraxanthine, ashwagandha, eleuthero, maca, GABA, theanine, and saffron, and why each one was chosen for its role in stress response, brain optimization, and sleep optimization. They also dig into the formulation challenges of building a clean-label supplement over a stimulant base, the real difference between caffeine and its downstream metabolite paraxanthine, and why this blend functions more like a foundational biohacking protocol than a beverage. You'll Learn: Why conventional energy drinks wreck your cortisol curve and what to do instead How paraxanthine delivers the benefits of caffeine without the jitters or sleep disruption The adaptogen trio (ashwagandha, eleuthero, and maca) and how they work together for stress response and human performance Why saffron is one of the most underrated nootropics for mood and brain optimization How gut health and the microbiome connect directly to your energy, metabolism, and longevity The mitochondria connection between willpower, physical performance, and entrepreneurial output How AI is reshaping small teams and what founders need to do right now to stay competitive Why the cleanest path to anti-aging and longevity starts with how you manage your energy across the day Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Gatlan | Book your free consultation at www.gatlan.com/DAVE - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jeff Boyd, MTE, More Than Energy, caffeine-free energy, paraxanthine, adaptogens, ashwagandha, eleuthero, maca, nootropics, saffron, GABA, theanine, prebiotics, gut health, stress response, cortisol management, sleep optimization, huckleberry acai, clean label formulation, stevia Reb A, energy drink alternative, paraxanthine vs caffeine, afternoon energy, Luggage Free, cycling endurance, long jump training, ADHD entrepreneurship, AI small teams, willpower mitochondria Resources: • Get 15% off your next order at: https://getmte.com/dave • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:42 – What Is MTE? 03:50 – Ingredients Deep Dive 09:49 – Flavors & Formulation 12:31 – Dave's Caffeine Origin 18:35 – Athletic Identity 22:38 – ADHD & Entrepreneurship 26:43 – AI & Future of Work 30:47 – Willpower & Mitochondria 35:34 – MTE Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3443: Ross Enamait challenges the assumption that obesity is simply the result of laziness, highlighting how demanding responsibilities, misinformation, and limited time can push fitness aside even for hardworking people. He encourages a more compassionate, solution-focused approach, showing how small, consistent efforts and practical home-based exercise options can help people regain control of their health. Read along with the original article(s) here: http://rosstraining.com/blog/2008/02/obese-isnt-always-lazy/ Quotes to ponder: "Fat does not equal lazy." "More often than not, several factors contribute to obesity. Laziness may or may not be present." "If we all spent more time trying to fix the problem, rather than cracking jokes about it, we'd all be better off." Learn more about your ad choices. Visit megaphone.fm/adchoices

The BOB & TOM Show – June 24, 2026 6:00 Hour6:08 – World Cup6:09 – Corn dog talk6:24 – His garage door (Tom)6:26 – Letter: Norway soccer team staying at the same hotel6:26 – Letter: His old master lock combination (Tom)6:28 – Letter: People who catch alligators use heavy-duty fishing equipment6:31 – Letter: Five-star restaurants have no condiments on the table due to clutter6:32 – Man stands still for 90 minutes during Congo match as memorial to slain leader6:46 – You are not on the anal probe list (Josh to Tom)6:49 – Old picture of Chick and his dad6:51 – Letter: Went to two upscale restaurants and had to carry sugar packets because there were no condiments6:54 – Letter: Retired listener who drives for a delivery service and listens every morning 7:00 Hour7:03 – Letter: IVF success story, now have an 11-month-old child7:05 – Letter: Hated Sea Hunt; Tom explains why he liked it7:07 – Letter: Your mom is so fat joke7:07 – Letter: Mr. Yuck stickers are still being sold7:09 – What got your mouth washed out with soap? (Tom and Josh)7:10 – Sports7:12 – I was too fat for a pogo stick (Chick)7:12 – Fat people on pogo sticks; it becomes a jackhammer (Josh)7:23 – Using headrests to break car windows if your vehicle goes into water7:25 – Tom, I wish you were anyone's press secretary (Josh)7:27 – Rock band Turtles discussion7:31 – Fastest male to skateboard across the United States7:33 – E-bikes are fast (Chick)7:47 – No sexting between Tom and Kelly7:49 – People have sexting buddies while dating someone else7:50 – Sex dolls are cheating (Kristi)7:50 – Sex dolls are not cheating (Josh)7:54 – Tom thought pictures were texting (Chick) 8:00 Hour8:06 – Need to be alone in the morning (Josh)8:09 – Tom is horrible at AI texting8:10 – Tom, how have you had kids? (Kristi)8:11 – All the women must have been asleep (Chick)8:20 – Ryan Hamilton interview8:22 – Got hit by a shuttle bus and suffered several broken bones (Ryan)8:23 – Mormon from Idaho (Ryan)8:32 – First late-night show appearance was Conan (Ryan)8:49 – Today in History 9:00 Hour9:07 – In studio: Jessica Alsman9:07 – I have things to tend to (Tom)9:08 – The show should be number one, Tom (Kristi)9:09 – Donut giveaway for anyone wearing red, white, and blue9:13 – Drinking beet juice may lower blood pressure (Kristi)9:27 – In studio: Jessica Alsman9:27 – No Alli; we answer letters9:29 – Letter: Guy is married but separated—should I date him?9:31 – No-drama dating9:31 – Letter: Dating a woman with large photos of herself on the walls9:33 – Letter: Boyfriend's ex keeps saying he's a jerk, but he's good to me9:33 – Letter: Girlfriend's mom is flirting with me—what should I do?9:36 – Lightning can travel through pipes (Tom)9:37 – Married four months and wants a bedroom divorce because he does not sleep well with another person9:50 – Man rescued from a waterless outdoor toilet after falling in while retrieving sunglasses Learn more about your ad choices. Visit podcastchoices.com/adchoices

Send us Fan MailIn this episode I sit down with Daffney Allwein, a 20-year exercise physiologist who works with high-performing, type-A CEOs and professionals. We talk about making fitness feel doable again without spending hours at the gym. And how small, intentional habits that support your energy, nervous system, strength, and longevity are the key to success. Why “I'm too busy” is often really a prioritization issueHow phone use and overstimulation drain the energy we need for our healthThe power of a simple 20-minute walk and finding movement you actually enjoyBuilding functional muscle in your 40s, cross-training, and letting go of ego-driven fitnessThe power of community, friendships in fitness and more! Find Daffney below:Website and Podcast click HERE Find Jess below!Website: Simply Jess Skincare SIMPLY JESS SKINCARE:Each and every product is naturally derived, highly concentrated and most importantly, super performing! Every product was born out of a need to have a truly pure product that met my high standards for efficacy. Subscribe to Our Newsletter! You can take 20% off Your Order of our all natural skincare line with code: PODCAST Shop Now! Favorite Supplements for Health and Fat loss: Click HERE  My favorites are the Power Greens, Digestive Enzymes and Brain Power Favorite Mouth and Face Tape- Use Code JESSICAITURZAETA15 for 15% off Click Here Mushroom Coffee-15% off with Code: SIMPLYJESSSKINCARE15 Click HereEmail Us! jess@learningtoglow.comFollow us! Instagram Tik Tok

Who should rule you? In Part 3 of the One Nation Under God series, Pastor Daniel Hayworth walks through Exodus and Deuteronomy to show how God designed Israel's government around shared authority, qualified leaders, and accountability under His law — the same pattern America's founders studied closely.Listen as Pastor Daniel traces Jethro's counsel to Moses, the origins of federalism, and Samuel's warning about the cost of demanding a king. It's a grounded study connecting ancient Scripture to how we live, vote, and lead today — ideal for your commute or workout.You'll Learn:✅ Why God designed shared, representative authority instead of one-man rule✅ How Exodus 18 shaped tiered, federalist government✅ The "FAT" test for godly leaders — Faithful, Available, Teachable✅ What Samuel warned would follow when Israel demanded a kingIf this study encourages you, follow Under God and share it with a friend. New episodes Monday, Wednesday, and Friday at 7 AM CT.

Longevity, Trauma Recovery, Circadian Health, Ramadan Fasting & Biohacking Your nervous system may be aging you faster than your diet. Learn how childhood programming, stress, sleep, fasting, resilience, and environment shape longevity, healthspan, metabolism, and human performance, and discover why some of the most powerful upgrades for your biology have nothing to do with supplements, nootropics, or the latest biohacking trends. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Learn more about Dr. Abirached's work at: https://limitlesshuman.ae/ Host Dave Asprey sits down with Dr. Elie Abirached, a Dubai-based longevity and biohacking strategist, Harvard alumnus, founder of Limitless Human, and CEO of Restore Fitness. After being smuggled out of Lebanon during the civil war as a teenager, he built a career helping high performers improve healthspan, resilience, recovery, metabolism, and longevity. Today he is one of the Middle East's leading voices in biohacking, healthy aging, human performance, sleep optimization, and lifestyle-driven longevity. Together, they explore why Dubai has become a global hub for biohacking and longevity, how extreme heat, light exposure, fasting, and modern lifestyle habits affect human biology, and why nervous system health may be one of the most overlooked drivers of long-term performance and anti-aging. They also dive into trauma, neuroplasticity, emotional resilience, metabolism, brain optimization, sleep quality, and the hidden programming that shapes your reactions, relationships, and health outcomes. You'll discover what the Middle East gets right about health and longevity, why resilience may be one of the most important predictors of healthy aging, and how your environment influences everything from recovery and mitochondria to sleep, energy, and mental performance. This episode offers practical insights for anyone interested in biohacking, human performance, longevity, fasting, sleep optimization, metabolism, brain optimization, emotional resilience, and building a stronger, more adaptable nervous system. You'll Learn: • How childhood experiences and unconscious programming influence longevity, healthspan, and human performance • Why nervous system regulation may be one of the most powerful anti-aging tools available • What Dubai's biohacking community gets right about health, recovery, and longevity • How fasting, including Ramadan-style fasting, affects metabolism, energy, and performance • The connection between neuroplasticity, emotional resilience, and brain optimization • How sleep optimization impacts mitochondria, recovery, aging, and cognitive function • Why environmental factors like heat, light exposure, air quality, and circadian rhythm matter more than most people realize • How to improve healthspan without relying solely on supplements, nootropics, ketosis, or the latest biohacking trends • Why stronger biology creates better decision-making, relationships, and long-term success • Practical strategies for building resilience in a world filled with stress, distraction, AI, and information overload Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. Use code DAVE30 for 30% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Elie Abirached, Dubai biohacking, UAE longevity, Middle East biohacking, Lebanon civil war survivor, resilience training, childhood trauma, nervous system regulation, emotional resilience, neuroplasticity, longevity medicine, healthy aging, human performance, sleep optimization, circadian rhythm, Ramadan fasting, intermittent fasting, metabolism optimization, stress adaptation, biological aging, mitochondria health, environmental health, heat adaptation, Dubai longevity, Limitless Human, Restore Fitness, healthspan, recovery optimization, biohacking Dubai, trauma and longevity Resources: • Learn more about Dr. Abirached's work at: https://limitlesshuman.ae/ • Order Dr. Abirached's Book ‘Limitless Human': https://a.co/d/0cwoQFRH • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:50 – War Zone Childhood 04:52 – Dubai Mission 08:08 – Childhood Trauma Programming 13:59 – Biohacking in Extreme Heat 19:37 – Fasting & Ramadan 25:15 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the reason tracking macros isn't working anymore has nothing to do with your discipline? In this episode, I break down one of the most common frustrations I hear from women: "I used to track macros, lose weight, and see results. Now I do the exact same thing and nothing happens.".  I want to share the story of how I once believed macros were the magic solution to fat loss, only to realize they were never the answer. They were simply a tool. We'll talk about why there is no perfect macro split, how the body constantly adapts to what we do, and why staying on the same nutrition plan for months or years can actually become part of the problem. I explain how functional nutrition often involves strategically changing calories, carbohydrates, fats, and protein to stay ahead of those adaptations rather than fighting against them. You'll learn why there may be a time for low-carb eating, a time for higher calories, a time for lower protein, and a time for a more balanced approach. Most importantly, we'll discuss how understanding macros can still be incredibly valuable when they're used within the right context. Today, I personally track my macros, not to lose weight, but to make sure I'm eating enough and maintaining the right balance for my current season of life.  If you've been wondering why your old nutrition strategy isn't producing the same results anymore, this episode will help you understand what changed and how to start working with your body instead of against it.   Time Stamps:   (1:47) Life Updates (3:06) My Macro Tracking Journey (4:47) Why Macro Tracking Gets A Bad Rap (8:22) Recent Client Example (12:32) Where To Start --------------------- Find Out More Information on Vital Spark Coaching --------------------- Follow @vanessagfitness on Instagram for daily fitness tips & motivation.  --------------------- Download Our FREE Metabolism-Boosting Workout Program --------------------- Join the Women's Metabolism Secrets Facebook Community for 25+ videos teaching you how to start losing fat without hating your life! --------------------- Click here to send me a message on Facebook and we'll see how I can help or what best free resources I can share! --------------------- Interested in 1-on-1 Coaching with my team of Metabolism & Hormone Experts? Apply Here! --------------------- Check out our Youtube Channel! --------------------- Enjoyed the podcast? Let us know what you think and leave a 5⭐️ rating and review on iTunes!

“You're Fat, Stop Eating”: The Power of Fasting And A New Way to Think About Body Fat by Oman Morales https://www.amazon.com/dp/B0DSB22DKM Fatistimenotweight.com “You're Fat, Stop Eating”: The Power of Fasting And A New Way to Think About Body Fat: By Oman Morales has achieved a remarkable feat by being as Top #50 best seller in One of Amazon’s categories. #38 Best Seller ★ in Teen & Young Adult Diet & Nutrition eBooks (Feb 18, 2025) Are you ready to transform your health and your life? You've tried countless diets, workout programs, and quick fixes, but nothing seems to deliver the lasting results you're after. You're not alone. The truth is, most approaches fail because they don't address the root of the problem. Excess body fat, low energy, and a rocky relationship with food aren't just physical issues—they're the result of a broken system that's been feeding us lies about health for decades. This book is your wake-up call. In You’re Fat Stop Eating, I strip away the noise and give you a clear, proven path to reclaim control over your body and mind. Through the science and simplicity of fasting, you'll learn how to unlock your body's natural power to heal, burn fat, and thrive. This isn't another diet gimmick or fitness fad—it's the key to real transformation. Here's what you'll discover: Why fasting is the ultimate reset for your body and brain. How to start fasting today, no matter your lifestyle. The surprising truth about body fat—and why it's not your enemy. How fasting supercharges longevity, immunity, and overall health. Practical strategies to break free from food cravings and emotional eating. This isn't just a book; it's a movement to empower you to live longer, feel stronger, and take control of your future. Whether you want to lose weight, improve your fitness, or prevent chronic illness, You’re Fat Stop Eating is your guide to unlocking the healthiest, happiest version of yourself. You've been lied to about what your body needs. It's time to rewrite the story. Your transformation starts now. About the author With over 30 years of expertise in the fitness industry, Oman Morales has dedicated his life to transforming how people approach health and wellness. Combining deep knowledge of fitness, nutrition, and human behavior, Oman delivers straightforward, actionable advice that empowers individuals to achieve lasting physical, mental, and emotional well-being. Oman's unique ability to simplify complex concepts has made him a trusted mentor to countless individuals seeking practical solutions to their health challenges. His no-nonsense approach is rooted in real-world experience and a passion for helping others break through barriers to unlock their full potential. Originally from Northern California, Oman now lives in Knoxville, Tennessee, with his wife and daughter. When he's not coaching or writing, Oman enjoys exploring new fitness methodologies, connecting with the community, and continuing his mission to inspire change one person at a time. Oman's work is a must-read for anyone ready to take control of their health and embrace a better future.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/If you're eating clean, taking the right supplements, and still feel exhausted and mentally foggy - the problem isn't your protocol. Your body has a built-in cellular cleanup system that determines whether any of those inputs actually work, and right now it's almost certainly switched off. In this video, I break down what that system is, how chronic stress and all-day eating suppress it without you ever feeling it, and the specific compounds that flip the longevity switch back on through independent biological pathways that nothing else touches.Thank you to our sponsors!ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – The Longevity Switch0:47 – Why Mitochondria Matter2:28 – What Mitophagy Is2:46 – How Mitophagy Works4:18 – What Shuts It Off8:54 – The Damage Compounds9:22 – How to Turn It Back On10:31 – Signal 1: Fasting11:48 – Signal 2: Exercise (REHIT)12:30 – Signal 3: Cold Exposure13:22 – Signal 4: NAD+14:29 – Signal 5: Urolithin A and SpermidineConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Check out Marek Health at https://marekhealth.com/syatt and get 10% OFF your first order using code: SYATTIn this episode of The Jordan Syatt Podcast, I shoot the breeze and answer questions from listeners with my podcast producer, Tony, and we discuss:- GLP-1 struggles- Dosage and coming off of GLP-1's- Fat loss for busy people- Losing weight or gaining muscle (which comes first?)- Is sodium a problem in frozen meals?- Clear communication in relationships- Bulgarian split squat science- Overcoming my hamstring injury- And more...Check out my FREE Calorie Calculator: https://linktw.in/vvLIHODo you have any questions you want us to discuss on the podcast? Give Tony a follow and shoot him a DM on Instagram - @tone_reverie - https://www.instagram.com/tone_reverie/ I hope you enjoy this episode and, if you do, please leave a review on iTunes (huge thank you to everyone who has written one so far).Finally, if you've been thinking about joining The Inner Circle but haven't yet... we have hundreds of home and bodyweight workouts for you and you can get them all: https://www.sfinnercircle.com/

Got Milk? It Might Have Less Protein and Fat. That story and more on H2O Radio's weekly news report. Headlines: The Trump administration has reversed its decision to dismantle a crucial ocean monitoring network. Human-caused climate change is skimming the amount of protein and fat in milk. The Trump administration's latest tactic to fight wind energy.

Sugar-Free Diets Disrupted Gut Microbiome and Metabolism A 16-week sucrose-free, low-fat diet study presented at ENDO 2026 found mice developed insulin resistance, impaired glucose tolerance, gut microbiome imbalance, intestinal inflammation, and fatty liver disease signs despite no weight gain or calorie difference. Host Dave Asprey breaks down why eliminating sugar entirely may be more detrimental than previously thought, the gut-bacteria-to-metabolism cascade that explains the metabolic damage, and why balanced nutrition matters more than simply removing sugar from your stack. Sources: https://www.sciencedaily.com/releases/2026/06/260614011843.htm https://www.medicalnewstoday.com/articles/how-eliminating-sugar-may-alter-the-gut-microbiome-mouse-study https://nypost.com/2026/06/13/health/going-sugar-free-can-mess-with-your-gut-and-metabolism/ ~~ Taurine Did Not Boost Acute Aerobic Performance A randomized, triple-blind, cross-over study of 16 physically active young adults found acute 1-gram taurine ingestion one hour before exercise produced no significant improvements in peak oxygen consumption, time to exhaustion, respiratory compensation point, or lipid/glycolytic metabolism variables. Host Dave Asprey explains why taurine remains popular in energy drinks and pre-workouts despite limited scientific evidence, what dosages and activity types future research should test, and why a reality check on a billion-dollar supplement category is exactly the kind of truth biohackers need. Sources: https://pubmed.ncbi.nlm.nih.gov/42268287/ https://www.sciencedaily.com/releases/2026/06/260611024609.htm ~~ Copper Therapy Improved Memory and Reduced Alzheimer's Proteins in Mice Lab trials from Monash University published in ACS Chemical Neuroscience found Cu(ATSM), a copper-delivery compound, increased P-glycoprotein abundance by 24.1 percent at the blood-brain barrier, reduced toxic amyloid-beta by 42 percent over 56 days, and improved spatial learning by nearly 44 percent in an Alzheimer's mouse model. Host Dave Asprey breaks down why repairing the brain's waste-clearing pump is a potential new therapeutic avenue for neurovascular dysfunction, why Cu(ATSM) has strong potential to fast-track into human clinics since it's already tested for Parkinson's and ALS, and why biometal therapies like this could be the next frontier in Alzheimer's treatment. Sources: https://www.news-medical.net/news/20260615/Lab-trials-prove-copper-therapy-enhances-cognitive-function-and-spatial-learning.aspx https://www.monash.edu/news/articles/copper-drug-restores-memory-and-clears-toxic-alzheimers-proteins https://pubs.acs.org/doi/10.1021/acschemneuro.6c00252 ~~ Socioeconomic Factors Biologically Embedded in Children's Brains A study of 2,300+ 9- and 10-year-olds published in Science found socioeconomic factors—household income, education, neighborhood quality—were the dominant variable affecting brain development, with MRI-visible differences in sensory processing and motor control regions linked to less sleep, more stress, and higher social media use in lower-income neighborhoods. Host Dave Asprey explains why socioeconomics became “biologically embedded” in preteen brains, how sleep-stress-screen circuits alter wakefulness and alertness, and why earlier studies focusing on IQ or mental health without accounting for environment may require reevaluation. Sources: https://www.npr.org/2026/06/11/nx-s1-5849937/child-brain-development-stress-sleep-neighborhood-economics https://abcdstudy.org/ ~~ Strength Training Sweet Spot for Longevity Is 90–120 Minutes Per Week A 30-year observational study of 147,374 participants published in the British Journal of Sports Medicine found 90–119 minutes per week of strength training delivered 13 percent lower all-cause mortality, 19 percent lower cardiovascular mortality, and 27 percent lower neurological mortality, with no additional benefit above 120 minutes. Host Dave Asprey breaks down why more isn't always better when it comes to resistance training, why combining strength with aerobic exercise dropped mortality risk by 45–58 percent at highest levels, and why 15–20 minutes a day or 30–40 minutes three times weekly is the minimum effective dose for longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260611024609.htm https://academic.oup.com/sleep/article/48/8/zsaf127/8129074 https://www.bmj.com/content/bsjspor/early/2025/06/11/bjsports-2025-110503 ~~ This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on sugar-free diet metabolic risks, taurine supplement efficacy, copper-based Alzheimer's therapeutics, childhood environmental brain development, and strength training longevity dosing. Host Dave Asprey connects preclinical animal data, randomized human trials, observational cohort research, and population neuroscience into actionable frameworks for extending healthspan, optimizing metabolism, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: sugar-free diet gut microbiome, insulin resistance sugar elimination, taurine aerobic performance, taurine supplement myths, Cu(ATSM) copper Alzheimer's therapy, blood-brain barrier P-glycoprotein, amyloid-beta reduction copper drug, spatial learning Alzheimer's mouse, socioeconomic brain development children, ABCD Study brain MRI, childhood biohacking environment, strength training longevity 90-120 minutes, British Journal Sports Medicine strength, weekly strength training dose, all-cause mortality resistance training, biohacking news 2026, longevity researchThank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Intro 0:20 – Story 1: Copper & Alzheimer's 2:42 – Story 2: Sugar-Free Diet 4:05 – Story 3: Strength Training Minimum Dose 5:48 – Story 4: Childhood Environment & Brain Development 7:42 – Story 5: Taurine 9:49 - Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episode 2816 - Vinnie Tortorich speaks with Dr. Zoe Harcombe about the myth of "settled science" and a new drug that is basically a "statin on steroids." https://vinnietortorich.com/2026/06/statin-on-steroids-episode-2816 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Vinnie's workout videos are available to purchase! Choose from a 2-day, 4-day, or 6-day workout–or buy all three at a discount! TO PURCHASE VINNIE'S WORKOUT VIDEOS, CLICK THIS LINK: https://vinnietortorich.com/workout A Statin on Steroids The resurgence of the Rice Diet. 6:00 The facts behind the scenes of that study/diet. It is also devoid of any real nutrients. Denise Minger took apart The China Study. The myth of low-carb and the misguided dietary guidelines. (21:00) Efforts to modify the guidelines to correct them have faced backlash. Fat has been incorrectly demonized. Confirmation bias is a real issue that hinders the search for the truth. (27:00) In 2019, Dr. Harcombe and her colleague initiated a defamation lawsuit after an article about them accused them of misinformation. (34:00) Extreme viewpoints on diet and health are not helpful. (42:00) What is Dr. Harcombe's opinion on the new statin Repatha (Evolocumab)? (52:00) Cholesterol is too important in the body, and forcing it too low could be risky. You can find Dr. Harcombe at https://www.zoeharcombe.com/ ALSO: Anna's products are now linked to PureVitamin Club's website. Look under the "Food and Snacks" section to purchase them there, too. (58:30) https://purevitaminclub.com/collections/food-and-snacks The NSNG® VIP GROUP IS NOW CLOSED AGAIN AS OF SUNDAY, MARCH 15TH Anna's next cookbook, Eat Happy Cocktail Hour, is filled with cocktails, mocktails, and appetizers and is available for pre-order right now. If you pre-order, you'll get bonus goodies! You can preorder from a wide variety of booksellers at https://eathappycocktailhour.com/ Save your receipt from wherever you preorder, you'll need it for your bonuses! Physical Release Date is October 2026 You can book a consultation with Vinnie to get guidance on your goals. https://vinnietortorich.com/phone-consultation-2/ More News Serena has added some of her clothing suggestions and beauty product suggestions to Vinnie's Amazon Recommended Products link. Self Care, Beauty, and Grooming Products that Actually Work! https://www.amazon.com/shop/vinnietortorich/list/3GPVU29UHHPMY?ref_=aipsflist Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Please make sure to watch, rate, and review it! Eat Happy Italian, Anna's second cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, on her website, and on Substack —they will spice up your day! https://annavocino.substack.com/ PURCHASE DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views it receives, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries

If you've ever wondered why weight loss gets harder the longer you diet, why every expert seems to have a different answer, or whether you really need to count calories to lose fat, this episode is for you.In Part 1 of this 4-part nutrition series, Britany breaks down the foundation of fat loss: calorie deficits, metabolism, metabolic adaptation, and why preserving muscle matters just as much as losing weight. She also explains why crash diets backfire, how popular diets actually work, and what women in perimenopause and menopause need to know about fat loss.In this episode, we discuss: What a calorie deficit actually is  The 4 ways your body burns calories  Why daily movement matters more than most people realize  Metabolic adaptation and why weight loss slows over time  Why bigger calorie deficits aren't always better  How keto, intermittent fasting, paleo, and other diets really work  The difference between weight loss and fat loss  Why preserving muscle is critical during a fat-loss phase  How strength training supports fat loss  The role of muscle in metabolism and long-term success  Fat loss during perimenopause and menopause  Why aggressive dieting often backfiresMentioned in the podcast:Free calorie calculatorSIGN UP FOR BRITANY'S NEWSLETTERhttps://britany.myflodesk.com/filterfreeASK BRITANY A QUESTION OR REQUEST A TOPIChttps://forms.gle/j9NC3yM5vrdBs8mJ8

Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world. Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now. You'll Learn: Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE. - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range Resources: • Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:34 – Dave Rabin Introduction 05:01 – Psychedelics and Psychiatry 08:35 – Psychedelic Safety and Dosing 14:53 – Serotonin Syndrome Warning 21:17 – Vagus Nerve and Safety 27:36 – Smartphones and Chronic Stress 34:18 – Defining Trauma 38:00 – Trauma and Epigenetics 40:23 – MDMA Cortisol Gene Repair 44:44 – Therapy vs. Medicine Alone 49:15 – FDA MDMA Rejection 55:35 – Ketamine Personal Experience 59:15 – Closing and Book Recommendation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

David Waldman delivers us to the weekend! His weekend, maybe even yours! Greg Dworkin is in and out right on schedule to catch the Knicks Parade and pick up his souvenir trashcan. Fat, evil, and stupid Is no way to go through life, and doesn't win many wars either. Unless we attacked Iran in order to provide them with new infrastructure, missiles, nuclear materials and terrorist support, you even might say that we actually "lost" Donald K. Trump's Iran war. Worst yet for neoconservatives, we might not get to attack Iran again for a little while. As Donald might say, we "pretty much shot our load"… Of course, the quicker we rearm Iran, the sooner we can nuke them. This is definitely not what Bibi Netanyahu ordered. Ben Shapiro blames the mean boys for abusing our poor dotard. On the bright side, Trump has been able to keep Ronald Reagan rolling in his grave for more than a decade now. For either one, war crimes don't seem that bad when their memory only goes back minutes. Trump signing off on his Iran war between dessert courses in Versailles might have made it harder for him to taco on it later, but Donald is always up for a challenge, unless it's challenging. The Palace Guard could have helped Trump get up that flight of stairs. Mexico? Cuba? Canada? Greenland? Intestinal or arterial blockage? What will Trump conquer next? Donald probably misses those days when it was just him and Jeff, some roofies and a checkbook. Tacoing out of Iran will be easy compared to the midterms. MAGAs and Gops are getting tired of each other. Dan Sullivan doesn't want to be associated with Dan Sullivan. Urban voters face voting hurdles that just irritate election reporters. Across the pond, Wallace and Gromit head to their polls to rotate out their latest PM.

Send us Fan MailIn this episode, I'm joined by Dr. Alan Rozanski, an internationally recognized cardiologist, researcher, and educator. I absolutely loved this conversation. Dr. Rozanski has connected the dots between our emotional health, stress levels, sense of purpose, and physical well-being.He shares the six domains of health and vitality and breaks each one down in a way that feels practical, inspiring, and easy to understand. We talk about how his work first began in practice with his own patients, when he saw firsthand how stress, depression, and lack of purpose could deeply affect physical health especially heart health.I loved how he shared not only the research and studies behind this, but also real-life examples and actionable tools we can use in our own lives. This episode is such an important reminder that health is not just about diet and exercise. Our mindset, relationships, purpose, stress, and emotional well-being all play such a huge role in how we feel and function.Dr. Rozanski was truly a joy to speak with, and I had so much fun with this one. I know there is something in this conversation for everyone to take away.Enjoy this episode!In This Episode, We Talk About:The six domains of health and vitalityHow emotional health impacts physical healthThe connection between stress, depression, and heart healthWhy purpose and meaning are so important for longevityHow mindset and connection can support better healthFind Dr Rozanski: HEREFind Jess below!Website: Simply Jess Skincare SIMPLY JESS SKINCARE:Each and every product is naturally derived, highly concentrated and most importantly, super performing! Every product was born out of a need to have a truly pure product that met my high standards for efficacy. Subscribe to Our Newsletter! You can take 20% off Your Order of our all natural skincare line with code: PODCAST Shop Now! Favorite Supplements for Health and Fat loss: Click HERE  My favorites are the Power Greens, Digestive Enzymes and Brain Power Favorite Mouth and Face Tape- Use Code JESSICAITURZAETA15 for 15% off Click Here Mushroom Coffee-15% off with Code: SIMPLYJESSSKINCARE15 Click HereEmail Us! jess@learningtoglow.comFollow us! Instagram Tik Tok

Run Off Election Tuesday. FBI arrests 5 in alleged plot to attack White House UFC event. Fat finger Post. See omnystudio.com/listener for privacy information.

Run Off Election Tuesday. FBI arrests 5 in alleged plot to attack White House UFC event. Fat finger Post. See omnystudio.com/listener for privacy information.

Run Off Election Tuesday. FBI arrests 5 in alleged plot to attack White House UFC event. Fat finger Post. See omnystudio.com/listener for privacy information.

Run Off Election Tuesday. FBI arrests 5 in alleged plot to attack White House UFC event. Fat finger Post. See omnystudio.com/listener for privacy information.

Intro; Holidays, Birthdays, Feedbag, Chub Hugs, Nostalgia, What’s In Your Lunchbox?, Hey Chubs, Advice; TV and Movie Reviews, and lots of chub talk! chubsgonewild@gmail.com Subscribe in iTunes! Right Click Here To Download ChubsGW646: Crash, Boom, Bears!

Skin Cancer Prevention, Anti-Aging Biohacking, and the Melanoma Detection Gap Most dermatologists are missing melanoma, and a board-certified skin cancer specialist explains exactly why, and what to do about it. This episode covers the detection tool that finds 10 times more melanomas, the real truth about sunscreen chemicals, the biohacking peptide that can hide cancer on your skin, and the cheap anti-aging drug that most people have never tried. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Michael Christopher, a board-certified dermatologist and expert dermoscopist recognized for his work in early melanoma detection. Through consistent, evidence-based use of dermoscopy, he identifies between 150 and 215 melanomas annually, far exceeding national and state averages and exposing a critical gap in standard skin cancer screening. Dr. Christopher speaks regularly on prevention, early detection, and systemic failures in dermatology training across health, wellness, and longevity-focused media, and has made it his mission to change the standard of care before more people die from a cancer that is almost always curable when caught early. Dave and Dr. Christopher break down why a standard skin exam with no additional tools is essentially a guess, how dermoscopy changes everything, and why most dermatologists who claim to use it actually cannot interpret what they see. They get into the real risk factors for rising melanoma rates, what sunscreen labels are not telling you, and how melanotan and other biohacking peptides interact with your skin cancer risk in ways that matter. They also cover tretinoin as one of the most evidence-backed anti-aging and skin optimization tools available, how red lighttherapy supports mitochondria function and skin rejuvenation, and what parents should know about protecting their kids' skin for long-term longevity You'll Learn: Why most dermatologists miss melanoma and what the detection gap actually looks like What dermoscopy is, how it works, and why you should ask for it by name How melanoma survival drops from 99% at stage one to 73% at stage three What the Prop 65 cancer warning on most pharmacy sunscreens actually means Why visible light can darken your skin even when you wear sunscreen How melanotan activates melanocortin receptors and why that may affect melanoma risk What Retin-A does to collagen, the epidermis, and long-term skin aging How AI is entering dermoscopy and where it still falls short The right concentration of tretinoin to start with and how to get through the adjustment period What parents should do now to protect their kids from melanoma later Thank you to our sponsors! -Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.-Timeline | Go to timeline.com/dave and you'll get an additional 20% off your first month-Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Michael Christopher, Dr. Michael Christopher, melanoma detection, dermoscopy, dermatoscope, skin cancer screening, melanoma prevention, early melanoma detection, skin cancer biohacking, sunscreen toxins, Prop 65 sunscreen, mineral sunscreen, zinc oxide, titanium dioxide, melanotan, melanocortin, skin aging, anti-aging, tretinoin, Retin-A, retinol, skin rejuvenation, collagen, red light therapy, mitochondria, UV exposure, UVB light, skin cancer longevity, melanoma survival rate, squamous cell carcinoma, functional medicine, human performance, longevity, biohacking, supplements, skin optimization, dermoscopy AI, skin cancer AI, visible light tanning, omega-6 sunburn, astaxanthin, skin health, melanoma staging, skin exam, skin cancer prevention Resources: • Learn More About Dr. Christopher's Work At: https://www.instagram.com/michael_christopher_md/ • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:41 – Guest Introduction 3:59 – Dermatoscope Explained 12:27 – Melanoma Rising: Why 16:57 – Melanotan & Sun Risk 21:14 – Melanoma & Longevity 22:31 – Stage 1 vs Stage 3 26:05 – Retin-A Deep Dive 38:53 – Loose Skin Solutions 41:26 – Kids' Skin Health See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

(00:00-25:52) Tim hates this song. (Sorry podcasters). Using McGreevy as a conduit to try to get to May. Kyle Berkshire's long drive and ball speed. Martin still getting caught up on old shows. Larry Nickel and Dan Janson are on hold let's go to Larry first. Is Larry full-time yet? Larry's favorite Cyndi Lauper songs. Larry recaps Raw and gives us his top 5 countries. Let's see what Dan Janson has to say. Dan plans to stop by Friday morning. Dan just wants to be a friend of the show. Fat or nah? Favorite canned foods.(26:00-44:30) Mt. Rushmore of Paramore songs. Will Dustin May join the show today? People trying to set up Iggy and Sharon in the YouTube chat. We have to pivot because Joe Lunardi's bracketology is out. How many all-stars are the Redbirds gonna have?(44:40-58:30) Disclosure Days. Movie Boi gives it 4/5 popcorns. Woke propaganda. Martin dabbles in yellow journalism. Why won't Jackson watch Girl Next Door? Radio silence from McGreevy on the D May front. Crashing weddings.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You'd think the lede was D May's one-hit complete game shutout, but it might be the Belgium-Egypt draw. Doug's ready to move May. Cardinals have never had a pitcher throw a perfect game. Jackson's lesbian pompadour. Brian Setzer and Subaru Outbacks. Audio of Dustin May talking about his performance and working with Jimmy Crooks. Gawking at nippers. Ignore the berating. A Hooterville pro tip.Music from the best red-headed musicians of all time. Willie Nelson coming to STL in August. Jelly Roll and Bunny divorcing. Sweet Sweet Ky influencing the Swift/Kelce wedding. No ring, no bring. Shout out Salad Fingers. Dan Orlovsky's Family Feud hair. World Cup with Papers on Friday.Stole redhead valor. Sharon wants to broker a truce between Warson Woods Wacko and Harrison's Brother Master on Friday morning. Morning chardonnay. Some on the program will be disappointed if the Cardinals don't make the playoffs. Pro liberty, anti kink shaming. Respect the great works of "The King."Tim hates this song. (Sorry podcasters). Using McGreevy as a conduit to try to get to May. Kyle Berkshire's long drive and ball speed. Martin still getting caught up on old shows. Larry Nickel and Dan Janson are on hold let's go to Larry first. Is Larry full-time yet? Larry's favorite Cyndi Lauper songs. Larry recaps Raw and gives us his top 5 countries. Let's see what Dan Janson has to say. Dan plans to stop by Friday morning. Dan just wants to be a friend of the show. Fat or nah? Favorite canned foods.Mt. Rushmore of Paramore songs. Will Dustin May join the show today? People trying to set up Iggy and Sharon in the YouTube chat. We have to pivot because Joe Lunardi's bracketology is out. How many all-stars are the Redbirds gonna have?Disclosure Days. Movie Boi gives it 4/5 popcorns. Woke propaganda. Martin dabbles in yellow journalism. Why won't Jackson watch Girl Next Door? Radio silence from McGreevy on the D May front. Crashing weddings.Brody Herman in-studio fired up about his Knicks winning the NBA Championship. Some Cardinal talk. Brody's not trying to be dismissive. Brody likes Blaze Jordan. What's next for troubled New York fans?Design Aire Heating & Cooling EMOTDZiggy Stardust. Thiago Splitter update if you please. Audio of Chip Caray's call of May's final strikeout in the 9th last night. "He was an opener, you pale liberal." People aren't happy Jackson doesn't know about "openers."Troy Percival. Turtleback greens. Which of Tim's imperfections (there aren't many) would he fix last? The deterioration of our nomenclature. Leg shortening surgery. Jackson's been challenged to a 1v1 at Triple Lakes.Audio from Cards Territory of Matt Holliday talking about Nolan Gorman being sent down to AAA and why the team decided to make the move. Doug thinks Gorman needs a fresh start. Maybe go live on Instagram.And the winner of the Design Aire Heating & Cooling EMOTD is...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Summary: In this episode, Justin Townsend and Adam Berkelmans explore the history, techniques, and safety considerations of fat-based preservation methods like confit, rillette, and oil preservation. They discuss how these ancient techniques transform food and remain relevant today. - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Leave a Review of the Podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Buy our Wild Fish and Game Spices⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Art of Venison Sausage Making⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Links: A Hunter's Guide to Confit Venison Shank Confit Chapters: 00:00 Introduction and Overview of Fat Preservation Techniques 02:50 The History and Evolution of Confit 06:02 The Science Behind Confit and Preservation 08:56 Rendering Fat: The Key to Successful Confit 11:51 Practical Applications and Modern Considerations 22:02 Unlocking the Value of Animal Fats 25:30 Exploring Confit and Rillette Techniques 30:04 Innovative Oil Preservation Methods 34:10 Safety in Fat and Oil Preservation 41:10 The Luxurious Transformation of Food Preservation Takeaways: History of confit and fat preservation Techniques for rendering and preserving fat Safety considerations and botulism risks Modern applications of traditional methods Transformative effects of fat on food texture and flavor Keywords: Food preservation, confit, rillette, fat preservation, wild food, traditional techniques, safety, botulism, rendering fat, culinary history Learn more about your ad choices. Visit megaphone.fm/adchoices

Everyone wants to know how "bounce back" after having a baby. The truth is, that's not the goal. In this episode, I'm sharing my postpartum fitness plan and the approach I'll be taking during those first weeks and months after birth. Instead of jumping straight into workouts, fat loss, or trying to get my body back as quickly as possible, I'll be prioritizing recovery, sleep, healing, and listening to what my body actually needs. I'll walk you through what my first few weeks postpartum may look like, including why I plan to spend most of the first week resting, when I might begin incorporating light walks and mobility work, and how I'll use my body's feedback, not a rigid timeline, to guide the process. We'll also talk about why pelvic floor health is at the center of my recovery plan and why I believe every woman should consider working with a pelvic floor physical therapist before problems arise, not just after. I'll share why I won't be rushing back into intense cardio, despite the pressure many women feel to lose baby weight as quickly as possible. We'll also discuss the truth about waist trainers, why external support can actually delay core recovery, and what a healthier approach to rebuilding strength looks like. Most importantly, I'm talking about something I think every new mom struggles with: comparison. Because no two postpartum journeys are the same, and comparing your recovery, body, or timeline to someone else's is one of the fastest ways to create unnecessary stress and frustration. If you're pregnant, postpartum, or simply curious about a more sustainable approach to recovery after birth, this episode will give you an honest look at how I'm thinking about this next chapter and why slower may actually be the smarter path forward.   Time Stamps:   (2:11) My Postpartum Fitness Plan (3:22) The Mental Side (9:19) Getting Your Body “Back” (11:20) Comparison In Postpartum (13:32) Sharing The Postpartum Journey --------------------- Find Out More Information on Vital Spark Coaching --------------------- Follow @vanessagfitness on Instagram for daily fitness tips & motivation.  --------------------- Download Our FREE Metabolism-Boosting Workout Program --------------------- Join the Women's Metabolism Secrets Facebook Community for 25+ videos teaching you how to start losing fat without hating your life! --------------------- Click here to send me a message on Facebook and we'll see how I can help or what best free resources I can share! --------------------- Interested in 1-on-1 Coaching with my team of Metabolism & Hormone Experts? Apply Here! --------------------- Check out our Youtube Channel! --------------------- Enjoyed the podcast? Let us know what you think and leave a 5⭐️ rating and review on iTunes!

Is retatrutide, the new triple agonist GLP-1, the next big thing in weight loss (or even rapid fat loss)?That depends on how the drug works, what the results are, the reality between the headlines and the evidence, and what happens to your weight when you stop.This episode breaks down retatrutide, the GLP-1, GIP, and glucagon triple agonist behind the largest weight loss numbers ever recorded in this class. It covers the Phase 2 obesity trial and the Phase 3 Triumph results, plus why cross-trial comparisons to semaglutide and tirzepatide deserve skepticism.We examine the body composition data (or lack thereof), and why a bigger number on the scale just amplifies the stakes for muscle mass, weight regain, and the off-ramp. Especially relevant for adults over 40 who are taking, considering, or planning to come off a GLP-1.Enroll in Eat More Lift Heavy, the 26-week coached program where adults over 40 build the nutrition and training skills to preserve muscle, lose fat, and manage their physique for life, including support for lifestyle changes needed while taking GLP-1s (and to come off them if desired).Timestamps:0:00 - Retatrutide and the biggest question for GLP-1 users 3:08 - How this new triple agonist works 4:46 - Phase 2 and Phase 3 weight loss numbers 5:38 - Cross-trial comparisons and their limits 6:23 - Fat, muscle, and what the trial did NOT measure 8:30 - Strength training over 40 and accelerated muscle loss 10:07 - Building the lifestyle (alongside using the drug) 14:10 - Resistance training and protein 16:00 - Rate of loss on a powerful drug like retatrutide 17:30 - The off-ramp when you stop 18:23 - Weight regain and body fat overshooting 22:03 - Retatrutide access and the gray market 24:11 - Bonus: 3-question test to keep your resultsEpisode Mentioned:Sometimes More Is More (The Sedentary Lifter Problem)

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/Over the last 15 years, I've built companies and spent millions testing what actually upgrades human performance, and I can tell you that mental fatigue has absolutely nothing to do with willpower. In this video, I break down the exact neurochemistry of deep focus. When your brain runs out of dopamine, norepinephrine, and acetylcholine, or gets bogged down by oxidative stress, your executive function collapses. The pharmaceutical industry wants you hooked on expensive stimulants that only treat the symptoms, but the real biological fix is a common antioxidant: Vitamin C.I explain how your brain hoards Vitamin C at levels 100 times higher than your blood, how to bypass the blood-brain barrier using SVCT2 transporters, and why eating sugar before you take it completely blocks its absorption. You'll also learn the exact biohacking stack—including NAC, CoQ10, PQQ, and L-theanine—you need to recycle this molecule, protect your mitochondria, and maintain effortless, razor-sharp focus all day long.Thank you to our sponsors!-KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Trailer00:21 – Focus Is Biology01:53 – Brain Chemistry Explained05:33 – Vitamin C Revealed07:09 – How to Dose08:18 – Absorption Barriers09:31 – Optimize Uptake10:00 – Oxidative Stress Problem11:00 – Stack for Deeper FocusConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

We've got some feedback on the white suit Fat wore to the footy last night; A very special guest walks into the room to put on Ch7 Pin on Damo; We're joined by Geelong's Mark O'Connor and Melbourne's Max Gawn; and there is Nuff and a questionable QuizSee omnystudio.com/listener for privacy information.

Semaglutide Slows Biological Aging A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigenetic clock in adults living with HIV-associated metabolic disease, with simultaneous improvements across inflammation, heart, kidney, liver, and brain markers. Host Dave Asprey breaks down why this isn't a weight loss story. It's a metabolic inflammation story. He explains why the GLP-1 mechanism hitting insulin signaling, oxidative stress, and inflammatory pathways simultaneously is the real finding, and makes the case that your metabolic markers and your aging markers are the same numbers. Sources: https://www.medicalnewstoday.com/articles/glp-1-drugs-ozempic-wegovy-may-slow-biological-aging https://www.nature.com/articles/s41467-026-72861-3 https://today.ucsd.edu/story/study-popular-glp-1-drug-may-slow-down-biological-aging FDA Approves First New Sunscreen Ingredient in 20 Years The FDA approved bemotrizinol as a permitted OTC sunscreen active ingredient, the first new approval in roughly two decades, clearing it for adults and children six months and older with broad UVA and UVB coverage and low skin absorption. Host Dave Asprey explains why twenty years of regulatory lag left American consumers with inferior chemistry while Europe moved on, why he's watching independent absorption data before updating his own stack, and why consistency of use matters more than perfect formulation when sun protection remains one of the most evidence-backed longevity interventions available. Sources: https://www.fda.gov/news-events/fda-newsroom/press-announcements/fda-expands-sunscreen-options-first-time-20-years https://www.accessdata.fda.gov/scripts/cder/omuf/index.cfm?event=OrderDetail&orderid=OTC000039 https://www.usatoday.com/story/news/health/2026/06/09/new-sunscreen-ingredient-bemotrizinol/90477659007/ Deoxyribose Gel Matches Minoxidil in Hair Regrowth Study Researchers testing a topical gel made from deoxyribose, the sugar backbone of DNA, saw roughly 80 to 90 percent hair regrowth in a mouse model of male-pattern baldness, matching minoxidil results and showing new follicle formation and increased blood vessel activity in treated areas. Host Dave Asprey breaks down why mouse hair regrowth studies have a long history of failing to translate to humans, what a plausible circulation-based mechanism would actually need to show in human trial data before it's worth acting on, and why the molecule itself is interesting enough to keep watching. Sources: https://www.reddit.com/r/Biohackers/comments/1tyt87w/researchers_found_that_a_gel_made_from/ https://www.sciencealert.com/surprise-hair-loss-breakthrough-a-dna-sugar-gel-sparks-robust-regrowth Caffeinated Chewing Gum and Exercise Performance A systematic review and meta-analysis of 21 studies found caffeinated chewing gum produces a small but real ergogenic effect for muscular strength and countermovement jump height, with buccal absorption delivering caffeine faster than capsules or drinks in a five to twenty-five minute pre-training window. Host Dave Asprey breaks down why delivery mechanism is an underrated variable in caffeine optimization, why timing matters as much as dose, and why a modest but measurable edge on a cheap and accessible tool is exactly the kind of practical biohack worth understanding. Sources: https://pubmed.ncbi.nlm.nih.gov/42228847/ https://doi.org/10.1519/JSC.0000000000005530 https://www.reddit.com/r/Biohackers/comments/1u0acgc/fastacting_caffeine_does_caffeinated_chewing_gum/ Vitamin A Overdoses Surge Nearly 40 Percent Medical News Today reported a 38.7 percent spike in vitamin A overdoses in early 2025, driven by online misinformation claiming high-dose vitamin A treats or prevents measles, a claim with no clinical support and real toxicity risk from fat-soluble accumulation in the liver. Host Dave Asprey explains the actual hepatotoxicity and bone demineralization risks of preformed retinol excess, draws the critical distinction between preformed retinol and beta-carotene that got lost in the misinformation cycle, and makes the case that mechanism is not a dosing protocol and confusing the two is how people get hurt. Sources: https://www.medicalnewstoday.com/amp/articles/vitamin-a-overdoses-rose-by-38-7-2025-how-to-get-right-amount World Cup 2026 and Mass Gathering Health Risk With the 2026 FIFA World Cup underway, public health researchers are flagging dense international crowds, high-volume travel, and shared indoor and outdoor spaces as an elevated transmission environment for respiratory illness. Host Dave Asprey reframes the conversation away from germ exposure and toward immune terrain, explains why your resilience going into a high-contact environment is a variable you actually control, and lays out the pre-exposure preparation window that matters most for anyone traveling or attending large events this summer. Sources: https://www.healthline.com/health-news/2026-fifa-world-cup-health-risks-protect-yourself This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on GLP-1 aging biology, sunscreen chemistry and regulatory science, emerging hair regrowth research, caffeine delivery optimization, supplement toxicity risk, and immune terrain preparation for mass gathering events. Host Dave Asprey connects randomized clinical data, epigenetic clock research, consumer health regulation, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: semaglutide biological aging, GLP-1 epigenetic clock, DunedinPACE aging marker, PCGrimAge mortality risk, bemotrizinol FDA approval, new sunscreen ingredient 2026, UVA UVB broad spectrum sunscreen, deoxyribose hair gel, minoxidil alternative hair regrowth, caffeinated chewing gum performance, buccal caffeine absorption, pre-workout caffeine timing, vitamin A overdose toxicity, preformed retinol hypervitaminosis, fat-soluble vitamin accumulation, World Cup 2026 health risk, immune terrain optimization, mass gathering respiratory illness, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:41 – Story 1: Ozempic Slows Aging Clocks 01:53 – Story 2: New Sunscreen Approved 03:12 – Story 3: DNA Sugar & Hair Regrowth 04:38 – Story 4: Caffeine Gum & Performance 06:13 – Story 5: Vitamin A Overdose Spike 07:59 – Story 6: World Cup & Immune Prep 09:34 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him. Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. . You'll Learn: Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one How to physically grow your hippocampus through exercise, meditation, and nutrition Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like The 7 everyday things that are shrinking your brain right now How stress, loneliness, and isolation cause measurable brain atrophy Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health Why VO2 max predicts brain aging better than almost any other marker What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely Why mitochondria health is the foundation of both brain function and longevity Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Pique | Go to Piquelife.com/dave for 20% off. - BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance Resources: • Learn More About Dr. Fotuhi's Work At: https://drfotuhi.com/ • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:59 – Intro 03:00 – Cannabis & Nicotine 04:15 – Understanding Alzheimer's 05:38 – Five Pillars Explained 07:55 – Best Cognitive Training 09:08 – Brain Size & Growth 12:36 – B12 & Lab Ranges 17:48 – Head-to-Toe Evaluation 24:17 – Sex & Brain Health 25:43 – Loneliness & Isolation 33:59 – ApoE4 Genetics 35:28 – Alzheimer's Declining 48:44 – Lithium & Brain 59:38 – VO2 Max & Fitness 1:06:42 – Psychedelics 1:09:38 – GLP-1s & Brain 1:12:38 – Closing & Action Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The protein shake Ben uses is Equip Foods Prime Protein (20% off, code BENAZADI):  https://bit.ly/4xzZI78  Pre-order Keto Flex Revised, out July 21st, and get free bonuses: https://bit.ly/4wKG1sM    Your belly fat isn't dead weight sitting around your waist. It's a biologically active organ, and the deep visceral fat around your organs sends inflammatory signals straight to your brain. Those signals shape your cravings, your mood, your memory, and your ability to feel full. One 2024 study found that people in their 20s and 30s with high visceral fat had nearly six times the risk of brain shrinkage. The late-night food noise and the willpower that keeps failing you aren't a character flaw. They're a broken biological signal. The good news: a 2026 study from Professor Iris Shai's team and Harvard showed that when people lost visceral fat and kept it off, brain shrinkage slowed and memory held strong into their 60s. This reverses. Key takeaways: Fat tissue is an endocrine organ, in the same category as your thyroid and adrenals Visceral fat, not the fat you can pinch, is the metabolically dangerous kind Leptin resistance is involved in roughly 90 percent of obesity cases, so it's a signaling problem, not a willpower problem Food noise is neurological: obesity lights up the same brain reward center as drug addiction Visceral fat is linked to depression and anxiety, independent of overall body weight Losing deep abdominal fat specifically, not just pounds, protects the brain, even against the APOE Alzheimer's gene 30 grams of protein per meal triggers your body's own GLP-1 and quiets cravings for free Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

Your eyes might be revealing metabolic disease long before your doctor catches it in bloodwork — and most people have no idea. In this episode, Dr. Vera Tarman sits down with Dr. Radka Toms, ophthalmologist, functional medicine practitioner, and founder of My Sugar Stop, to explore the fascinating and largely unknown connection between sugar, gut health, and your vision. Dr. Toms shares her own story — from a "hardcore conventional doctor" eating chocolate bars for lunch to developing rosacea and insulin resistance and eventually pioneering the field of nutritional ophthalmology. What You'll Learn:

Burn Fat While You Sleep, Boost Metabolism & Fast the Smart Way with guest expert Dr. William Li #64What if everything you've been told about metabolism, fat, and weight loss is wrong? In this episode, Samantha sits down with Dr. William Li for a second conversation in season 2 (Check out Episode #62, if you missed it - and Season 1 Episode #14 as well!).Dr. Li dismantles everything you thought you knew about metabolism, visceral fat, and intermittent fasting — revealing the science-backed strategies that let your body burn dangerous fat while you sleep, eat, and live your life.Dr. Li is an internationally renowned physician-scientist, president of the Angiogenesis Foundation, and New York Times bestselling author of Eat to Beat Your Diet — to expose the myths that have kept so many women stuck in a cycle of dieting, frustration, and self-blame.Spoiler: your metabolism is not broken. It never was.From the newly discovered science proving that human metabolism stays rock-stable from age 20 to 60, to the hidden danger of "skinny fat" and its shocking link to breast cancer, to the brilliantly simple 12-hour fasting protocol Dr. Li himself follows every day — this episode is a masterclass in working with your body instead of against it. Plus, the true origin story of the famous 16:8 intermittent fasting method that no one is talking about.WHAT YOU'LL LEARN:Your metabolism is NOT slowing down: Learn the findings from a landmark study of 6,000 people that completely rewrites what we thought we knew about metabolism — and where the real culprit actually lives.Fat is a hormone-producing organ: Discover why healthy fat is essential to your metabolic function, and what happens to your hormones when it starts to grow out of control.Excess fat behaves like a tumor: Find out why Dr. Li says too much body fat follows the same dangerous playbook as cancer — and why that makes chronic inflammation so much more urgent to address.Skinny fat is a real and serious risk: Learn what a 13-year Cornell study found when it scanned nearly 3,500 normal-weight women — and why the results are a wake-up call for women who think they're in the clear.Foods that burn fat at the cellular level: Discover which everyday grocery store foods contain natural bioactives that work against fat growth — and how they do it without you changing everything on your plate.The tape measure test: Find out why your waistline tells a more accurate story about your health than your BMI, your scale, or your body size — and how to use it at home for free.Why 12 hours of fasting is enough: Learn the surprisingly achievable protocol Dr. Li follows himself every single day — and why the research says you don't need to go longer to see real results.The truth about 16:8: Discover the origin story of the most popular intermittent fasting method — and why its famous time window has almost nothing to do with human science.Insulin is the metabolic switch: Understand the simple biological reason your body burns fat while you sleep — and how the timing of your last meal determines how hard it works overnight.Ultra-lean is not ultra-safe: Find out why the medical literature puts extreme leanness in the same dangerous category as extreme obesity — and what that means for how we define a healthy goal.About Our GuestDr. William Li is an internationally renowned physician, scientist, researcher, and author whose work has impacted over 70 diseases, including cancer, diabetes, and cardiovascular disease. He is the founder and president of the Angiogenesis Foundation and is best known for his groundbreaking TED Talk, Can We Eat to Starve Cancer?, which has been viewed by millions worldwide. He is the New York Times bestselling author of Eat to Beat Disease and Eat to Beat Your Diet: Burn Fat, Heal Your Metabolism, and Live Longer.

You HAVE to see this — Karmelo Anthony sobbing in court after being sentenced to 35 years in prison for the cold-blooded murder of Austin Metcalf at a Texas high school track meet. Pat Gray breaks down the shocking verdict, the victim's family's powerful statements, and the hate-filled racial protests that erupted outside the courthouse as Anthony's supporters screamed “Free Karmelo!” and called the entire trial racist. This wasn't self-defense. Anthony was asked to move 15 times, warned Metcalf “touch me and find out,” then stabbed the 17-year-old peacemaker straight in the chest. The jury saw through the excuses, rejected the “sudden passion” defense, and delivered real justice in one of Texas' most conservative counties. We also cover: SPLC president defends Graham Platner? McDonald's about to release “Archy” AI drive-thrus. TrumpRX just added 800 MORE medications.  Dr. Alveda King DESTROYS Jamie Raskin in fiery showdown. WNBA's Brianna Turner questions wearing the “USA 250” patch. I'm reading every single comment from patriots like you. Drop your hottest take and let's stand together for real justice and accountability. If you're tired of the media pushing excuses for violent crime while ignoring innocent victims like Austin Metcalf, smash that LIKE button, SUBSCRIBE, and turn on notifications so you never miss Pat's unfiltered truth. 00:00 Pat Gray UNLEASHED! 00:36 Karmelo Anthony Guilty Verdict 03:11 Outside the Karmelo Anthony Trial 04:36 Fox News Announces Karmelo Anthony Verdict 06:22 Court TV Has a Meltdown over Karmelo Anthony Verdict 08:04 More of Upset People Outside the Karmelo Anthony Trial 13:14 We Have a Chasm! 17:34 Pat Gray BINGO! Winner 19:08 Graham Platner Officially Nominated 19:52 AOC on Graham Platner 21:22 Graham Platner Recruited by Two Socialists 25:15 SPLC President Asked about Graham Platner 26:30 SPLC President Asked about Pro-Life Advocates 31:39 Chewing the Fat 45:49 Brendan Sorsby Situation 48:17 Expansion of TrumpRx 51:19 SPLC President VS. Chip Roy 53:19 SPLC President VS. Darrell Issa 54:58 Jim Jordan on SPLC / Biden Administration Connection 55:55 Jim Jordan on SPLC Pocketing Money 58:14 Alveda King's Opening Remarks 1:00:15 Alveda King VS. Jamie Raskin 1:01:20 Jasmine Crockett Belittles Alveda King 1:02:04 Jasmine Crockett Attacks Charlie Kirk Post-Mortem 1:04:00 Wesley Hunt Claps Back against Jasmine Crockett 1:07:15 Trump on Iran's Power Plants & Bridges 1:08:36 Drone Boat Rescue of Two U.S. Pilots 1:12:24 Walton Family on Fox News 1:14:26 WNBA has Issues with U.S.A. 250 Jersey Patch 1:18:43 AI-Generated James Talarico Ad 1:19:40 John Thune Asked about the SAVE Act 1:22:51 How Spencer Pratt Lost the LA Mayoral Race? 1:28:32 DC Reflecting Pool Timelapse 1:32:40 Lee Zeldin Stopping Animal Testing? Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 2812 - Vinnie Tortorich and Chris Shaffer discuss food dyes and disease, what their effects could be, and much more. https://vinnietortorich.com/2026/06/food-dyes-and-disease-episode-2812 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Vinnie's workout videos are available to purchase! Choose from a 2-day, 4-day, or 6-day workout–or buy all three at a discount! TO PURCHASE VINNIE'S WORKOUT VIDEOS, CLICK THIS LINK: https://vinnietortorich.com/workout Food Dyes and Disease Ideas to boost protein. (5:00) There is a side quest discussion regarding yachts, private jets, and helicopters. (16:00) Food dyes are being removed from some Jell-Os. (26:00) A hundred thousand participants in a French study said that food coloring additives, even natural ones, increase the risk of chronic disease. (29:00) Findings suggest that even natural food colorings can increase the risk of diabetes and even cancer. It's not necessarily about the food coloring, but also the crap food they go into, like sugary cereals. (31:00) "Fat-free" foods are often loaded with more sugar and sweeteners. (39:15) Also, natural food dye in a generally unhealthy food doesn't make it any better for you. The NOVA definitions of ultra-processed foods originated in Brazil. (40:30) Brazil is moving to ban ultra-processed foods from both hospitals and schools. The food at those two places must be freshly prepared. Vinnie shares a story about his shoulder surgery and how being NSNG helped his healing, because NSNG can help reduce inflammation. (42:00) ALSO: Anna's products are now linked to PureVitamin Club's website. Look under the "Food and Snacks" section to purchase them there, too. (58:30) https://purevitaminclub.com/collections/food-and-snacks The NSNG® VIP GROUP IS NOW CLOSED AGAIN AS OF SUNDAY, MARCH 15TH Anna's next cookbook, Eat Happy Cocktail Hour, is filled with cocktails, mocktails, and appetizers and is available for pre-order right now. If you pre-order, you'll get bonus goodies! You can preorder from a wide variety of booksellers at https://eathappycocktailhour.com/ Save your receipt from wherever you preorder, you'll need it for your bonuses! Physical Release Date is October 2026 A New Sponsor Jaspr Air Scrubbers has a discount code, VINNIE, that gets you $200 off for a limited time. Jaspr offers a lifetime warranty. Go to Jaspr.co for more information or to purchase. (1:05:00) You can book a consultation with Vinnie to get guidance on your goals. https://vinnietortorich.com/phone-consultation-2/ More News Serena has added some of her clothing suggestions and beauty product suggestions to Vinnie's Amazon Recommended Products link. Self Care, Beauty, and Grooming Products that Actually Work! https://www.amazon.com/shop/vinnietortorich/list/3GPVU29UHHPMY?ref_=aipsflist Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Please make sure to watch, rate, and review it! Eat Happy Italian, Anna's second cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, on her website, and on Substack —they will spice up your day! https://annavocino.substack.com/ PURCHASE DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views it receives, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries

Send us Fan MailI am sharing my top five tips for the best sleep! I recently got a 99 sleep score and my sleep has been so good.Since tracking my sleep, I have really been able to figure out what is working, what keeps my score high, and what has been tanking it. This is such an important topic for our health. Because so much regeneration and repair happens while we sleep, I thought sleep deserved its own episode!Let me know if you have any questions or feedback. As always, you can send me an email or a DM on Instagram. Mouth Tape: Click Here  JESSICAITURZAETA15  for 15% offFind Jess below!Website: Simply Jess Skincare SIMPLY JESS SKINCARE:Each and every product is naturally derived, highly concentrated and most importantly, super performing! Every product was born out of a need to have a truly pure product that met my high standards for efficacy. Subscribe to Our Newsletter! You can take 20% off Your Order of our all natural skincare line with code: PODCAST Shop Now! Favorite Supplements for Health and Fat loss: Click HERE  My favorites are the Power Greens, Digestive Enzymes and Brain Power Favorite Mouth and Face Tape- Use Code JESSICAITURZAETA15 for 15% off Click Here Mushroom Coffee-15% off with Code: SIMPLYJESSSKINCARE15 Click HereEmail Us! jess@learningtoglow.comFollow us! Instagram Tik Tok

Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your blood vessels hold the real key to biological aging. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. William Li, an internationally renowned physician, scientist, and two-time New York Times bestselling author of "Eat to Beat Disease" and "Eat to Beat Your Diet." As President and Medical Director of the Angiogenesis Foundation, Dr. Li's groundbreaking research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases including diabetes, heart disease, blindness, and obesity. His TED Talk, "Can We Eat to Starve Cancer?", has surpassed 11 million views, making him one of the most trusted voices at the intersection of functional medicine and food as medicine science. Together they dig into the biology of SuperAgers, the vascular markers that predict how long you'll live, and why flow-mediated dilation may be the most underrated biohacking measurement tool available today. Dave shares what happened after four separate gene therapies, including klotho and VEGF, and Dr. Li explains why your metabolism, mitochondria, and gut microbiome show up in the data on every centenarian ever studied. They also get into the microplastic crisis, the cribriform plate pathway that delivers airborne particles directly to your brain, and why your tongue is the first place your body quietly stores fat. You'll Learn: What centenarian research reveals about immune function, gut health, and vascular resilience Why 50% of food extracts matched or outperformed cancer drugs in head-to-head angiogenesis testing How microplastics travel through your nose directly to your central nervous system What flow-mediated dilation and pulse wave velocity tell you about your true biological age Why your hind-third tongue fat is an overlooked early warning sign for sleep apnea and metabolism problems What Dave's four gene therapies (klotho, VEGF, follistatin) actually did to his body How the vagus nerve connects gut health to brain optimization, stress resilience, and longevity Why genetics now accounts for roughly half of longevity outcomes, and what that means for the future of gene therapy How to use biohacking tools to compound your health the same way you compound financial returns Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order. - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: William Li, Dr. William Li, Eat to Beat Disease, angiogenesis, food as medicine, centenarians, SuperAgers, longevity, anti-aging, biohacking, vascular health, flow-mediated dilation, pulse wave velocity, microplastics, cribriform plate, gene therapy, klotho, VEGF, follistatin, mitochondria, metabolism, gut health, vagus nerve, sleep apnea, functional medicine, human performance, brain optimization, cancer prevention, inflammation, immune system Resources: • Learn More About Dr. Li's Work At: https://drwilliamli.com • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 02:33 – William's Background 06:21 – Food vs. Cancer Drugs 14:09 – Gene Therapy 23:50 – Centenarian Research 27:41 – Stress & the Vagus Nerve 37:31 – Vascular Health 42:34 – Microplastics 53:19 – Novel Biomarkers See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 seconds, my severe brain fog lifted, and my metabolism completely shifted.In this video, I break down exactly why adding sugar to your morning coffee is destroying your metabolism, spiking your insulin, and keeping you fat. I explain the hard science behind the alternative: blending "fat cubes" (grass-fed butter) and MCT oil into your coffee. I reveal how this specific combination of butyrate, CLA, and medium-chain triglycerides bypasses traditional digestion to go straight to your liver, instantly converting into ketones for pure brain fuel. You'll learn how eating more fat actually trains your body to burn its own stored fat, allowing me to hit 4.8% body fat at 50 years old with a biological age in my 30s—without hunger, without a 3 PM crash, and without living in the gym.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayViome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – Intro 00:42 – Pancreatic Cancer Halted by Virus Injection 01:44 – Teens & AI Therapy Chatbots 03:13 – GLP-1 Drugs Cut Breast Cancer Risk 04:30 – Russia's $26B Longevity Program 06:18 – Sauna vs. Cold Plunge 09:10 – ClosingConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Pancreatic Cancer Halted by Virus Injection Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's dense biological wall becomes less of an advantage when a virus can replicate inside it directly, and why a measurable response at a safety dose is the kind of early signal that changes how he's watching this field. Sources: https://www.newscientist.com AI Chatbots and Teen Mental Health A new survey shows roughly one in five adolescents and young adults are now going to AI chatbots when they feel sad, anxious, nervous, or stressed, with usage heaviest in the 18–21 range. Host Dave Asprey explains why general-purpose language models designed to be engaging are dangerous as a substitute for real mental health support, why false reassurance from a chatbot may make the pipeline to real care harder to reach, and why this is a health systems story masquerading as a tech adoption story — and what parents need to do about it. Sources: https://www.nbcnews.com GLP-1 Drugs Cut Breast Cancer Risk Penn Medicine published a retrospective analysis of over 111,000 women finding GLP-1 exposure associated with about 35% lower odds of breast cancer in the full cohort and around 30% lower in a matched comparison group. Host Dave Asprey breaks down why this isn't just a weight loss story — it's a metabolic dysfunction story — explains the insulin resistance, inflammation, and hormonal environment mechanisms that may be driving the signal, and makes the case that this finding should be reshaping how oncologists and OBGYNs think about high-risk patients right now. Sources: https://www.pennmedicine.org Putin's $26 Billion Longevity Program The Wall Street Journal reports that Russia has made anti-aging research a Kremlin-level national priority through a $26 billion program including gene therapy, organ bioprinting, and xenotransplantation, led by Putin's daughter Maria Vorontsova and physicist Mikhail Kovalchuk. Host Dave Asprey breaks down what's geopolitical theater, what's legitimately frontier science, and why the real question is whether any findings will make it out to the broader research community or get locked inside a state program. Sources: https://www.wsj.com https://www.france24.com Sauna vs. Cold Plunge A landmark Finnish study tracked over 2,300 men for nearly 21 years and found increasing sauna frequency associated with dramatically lower cardiovascular and all-cause mortality — strongest at four or more sessions per week. Host Dave Asprey settles the debate with the actual data, explains what heat shock proteins and cold shock proteins actually are and why the evidence base behind them is nowhere near equivalent, and calls out the wellness marketing presenting early-stage mouse model research as the cold water equivalent of two decades of human mortality outcomes. Sources: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2521522 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cancer treatment breakthroughs, adolescent mental health and AI, metabolic drivers of disease, geopolitical longevity science, and the real evidence behind popular recovery modalities. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: oncolytic virus pancreatic cancer, engineered virus tumor treatment, AI chatbot teen mental health, adolescent AI emotional support, GLP-1 breast cancer risk, semaglutide cancer prevention, metabolic dysfunction root cause disease, Putin longevity program Russia, New Health Preservation Technologies, anti-aging biotech geopolitics, sauna longevity mortality data, cold plunge cold shock proteins, RBM3 heat shock proteins, sauna vs cold plunge evidence, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today - Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:42 – Pancreatic Cancer Halted by Virus Injection 01:44 – Teens & AI Therapy Chatbots 03:13 – GLP-1 Drugs Cut Breast Cancer Risk 04:30 – Russia's $26B Longevity Program 06:18 – Sauna vs. Cold Plunge 09:10 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body.. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time. They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time. You'll Learn: Why microplastics accumulate inside lysosomes and what sulforaphane does to release them How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin What an in-house study revealed about how and where microplastics actually leave the body How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch How sulforaphane boosts BDNF and neuroplasticity at the cellular level What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - Timeline | Go to timeline.com/dave and you'll get an additional 20% off your first month - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox Resources: • For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:55 – Intro & Context 4:48 – Microplastics & Sulforaphane 12:39 – Broccoli Sprouts Formulation 15:20 – Lab Origin Story 26:01 – Reducing Toxin Exposure 37:06 – Estrogen, Hormones & Berberine 52:46 – Autism, ADHD & Brain Health 59:01 – Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

“I'd  like to propose a toast to the garden, to this beautiful planet, and to the gardener. You know,  some people have gardens, some people don't. But, they need to have a garden because Grandfather used to say, “We are all a garden in the world." So, I give thanks to the garden and the gardener.” —Carlo MontesantiAnd so, we have gathered to the final course in this banquet, Dolce. Dessert. Here at this table, we reflect on inheritance. Returning once more to conversations with Carlo Montesanti, Jessie Jowers, and Arianna Gelpke, this episode lingers on to ask if we can remember landscapes, and if we can do so over a shared meal. What does it mean to grow (food, family, and tradition), in a world that has increasingly been shaped by speed, extraction, automation and touristic ideals? Amidst these changes, what remnants will we be able to conserve? In "Dolce," we continue our walk at Slow Life Family Farm, moving between memory, archaeology and rituals made at the dinner table and reflect on the legacy of slow food—that it is not a cuisine and, maybe even, not exclusive to the romantic imagings of Italian provincial life. Perhaps, it is about the way we attend to Earth and care for its continuity, asking not what we can take from it, but what we can give in return. We also join Arianna at Corzano e Paterno to discuss the process of "reading the grapes" and the factors that influence wine-making. This episode contemplates sweetness as something more than a flavour, as a longing for ways of living that keep us in relation to one another and the land which feeds us. Fat of The Land is a series that asks us what we mean when we look for connection between people and the land. Following a desire for real relation, for deliciousness, and for slowness, each episode traces what happens when we follow this desire. This episode is brought to you by generous sponsorships from Ritū and Terra Elaÿa. Music and sound design in this episode is brought to you from the For The Wild Studio.Thank you to Carlo and Jessie of Slow Life Family Farm and Arianna of Fattoria Corzano and Paterno  for joining us in conversation.BiographiesCarlo Montesanti: Born in Siracusa, Carlo is an esteemed English-speaking guide in Eastern Sicily, known for his work with BBC nature documentaries and Netflix's Chef's Table series.Jessie Jowers: With a passion for the traditional uses of plants, Jessie brings a wealth of knowledge about local crafts, foods, and medicines to our farm's daily life. Arianna Gelpke: Arianna Gelpke is a representative of Fattoria Corzano and Paterno, working in the family farm, and wine, cheese and oil production. She is passionate for nature and working with the land in the pursuit of sustainable agriculture and high-quality artisan produce. Since Wendelin Gelpke purchased Corzano in 1971 and the subsequent addition of Paterno in 1974, the two-hundred-hectare farm has developed along three different lines: wine and oil production, artisanal sheep's cheese production, and “Agriturismo.”Partners RitūFat of The Land is a series about what it means to be in relationship with land, food, and the people who tend both across generations. Ritū was made with the same kind of care; six ancient plants, ground and blended into a morning cup that honors the land it comes from, delivered in a compostable bag that returns to the earth.Ritu built a custom landing page for us and would like to offer For The Wild listeners 25% their first month with a discount code FORTHEWILD25. To order yourself some Ritu, head to: drinkritu.com/forthewild Terra ElaÿaThanks also to Elaÿa for the support of this series. Terra Elaÿa is a sanctuary where ancient ways meet the needs of our time. We emerge at this time of crossroads, standing as a space for the transformation, renewal, and re-enchantment of the human spirit. Located in the heart of southern Italy, we provide a place to come into a deeper relationship with life: to slow down, listen, and restore embodied wisdom.Head to terraelaya.com to learn more upcoming Elaÿa experiences or to host an event.  Support the show

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is transforming personalized peptide protocols in functional medicine Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy Resources: • Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro & Guest Welcome 01:55 – Censorship & Platform Bans 06:20 – Peptide Science & Bioavailability 07:20 – Delivery Methods 14:30 – Supply Chain & US Manufacturing 17:01 – Manufacturing Risks & Contamination 24:43 – Peptide Stacks 28:41 – Immune Peptides & Thymus 30:57 – Overhyped Peptides 41:00 – Alternative Delivery (Patches, Nasal, Rectal) 47:25 – Side Effects & Risk 50:30 – Mixing & Storage Tips 54:05 – Wrap-Up & Where to Buy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Personal Experience00:47 – Root Cause: Not in Your Head01:05 – Blood Flow and Brain Function02:10 – The Calf Pump03:52 – Foot Sensory Signals04:26 – Nervous System Impact06:22 – How to Fix It07:51 – Personal ResultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.