Podcasts about Fat

Run Off Election Tuesday. FBI arrests 5 in alleged plot to attack White House UFC event. Fat finger Post. See omnystudio.com/listener for privacy information.

Run Off Election Tuesday. FBI arrests 5 in alleged plot to attack White House UFC event. Fat finger Post. See omnystudio.com/listener for privacy information.

Run Off Election Tuesday. FBI arrests 5 in alleged plot to attack White House UFC event. Fat finger Post. See omnystudio.com/listener for privacy information.

Run Off Election Tuesday. FBI arrests 5 in alleged plot to attack White House UFC event. Fat finger Post. See omnystudio.com/listener for privacy information.

You'd think the lede was D May's one-hit complete game shutout, but it might be the Belgium-Egypt draw. Doug's ready to move May. Cardinals have never had a pitcher throw a perfect game. Jackson's lesbian pompadour. Brian Setzer and Subaru Outbacks. Audio of Dustin May talking about his performance and working with Jimmy Crooks. Gawking at nippers. Ignore the berating. A Hooterville pro tip.Music from the best red-headed musicians of all time. Willie Nelson coming to STL in August. Jelly Roll and Bunny divorcing. Sweet Sweet Ky influencing the Swift/Kelce wedding. No ring, no bring. Shout out Salad Fingers. Dan Orlovsky's Family Feud hair. World Cup with Papers on Friday.Stole redhead valor. Sharon wants to broker a truce between Warson Woods Wacko and Harrison's Brother Master on Friday morning. Morning chardonnay. Some on the program will be disappointed if the Cardinals don't make the playoffs. Pro liberty, anti kink shaming. Respect the great works of "The King."Tim hates this song. (Sorry podcasters). Using McGreevy as a conduit to try to get to May. Kyle Berkshire's long drive and ball speed. Martin still getting caught up on old shows. Larry Nickel and Dan Janson are on hold let's go to Larry first. Is Larry full-time yet? Larry's favorite Cyndi Lauper songs. Larry recaps Raw and gives us his top 5 countries. Let's see what Dan Janson has to say. Dan plans to stop by Friday morning. Dan just wants to be a friend of the show. Fat or nah? Favorite canned foods.Mt. Rushmore of Paramore songs. Will Dustin May join the show today? People trying to set up Iggy and Sharon in the YouTube chat. We have to pivot because Joe Lunardi's bracketology is out. How many all-stars are the Redbirds gonna have?Disclosure Days. Movie Boi gives it 4/5 popcorns. Woke propaganda. Martin dabbles in yellow journalism. Why won't Jackson watch Girl Next Door? Radio silence from McGreevy on the D May front. Crashing weddings.Brody Herman in-studio fired up about his Knicks winning the NBA Championship. Some Cardinal talk. Brody's not trying to be dismissive. Brody likes Blaze Jordan. What's next for troubled New York fans?Design Aire Heating & Cooling EMOTDZiggy Stardust. Thiago Splitter update if you please. Audio of Chip Caray's call of May's final strikeout in the 9th last night. "He was an opener, you pale liberal." People aren't happy Jackson doesn't know about "openers."Troy Percival. Turtleback greens. Which of Tim's imperfections (there aren't many) would he fix last? The deterioration of our nomenclature. Leg shortening surgery. Jackson's been challenged to a 1v1 at Triple Lakes.Audio from Cards Territory of Matt Holliday talking about Nolan Gorman being sent down to AAA and why the team decided to make the move. Doug thinks Gorman needs a fresh start. Maybe go live on Instagram.And the winner of the Design Aire Heating & Cooling EMOTD is...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

(00:00-25:52) Tim hates this song. (Sorry podcasters). Using McGreevy as a conduit to try to get to May. Kyle Berkshire's long drive and ball speed. Martin still getting caught up on old shows. Larry Nickel and Dan Janson are on hold let's go to Larry first. Is Larry full-time yet? Larry's favorite Cyndi Lauper songs. Larry recaps Raw and gives us his top 5 countries. Let's see what Dan Janson has to say. Dan plans to stop by Friday morning. Dan just wants to be a friend of the show. Fat or nah? Favorite canned foods.(26:00-44:30) Mt. Rushmore of Paramore songs. Will Dustin May join the show today? People trying to set up Iggy and Sharon in the YouTube chat. We have to pivot because Joe Lunardi's bracketology is out. How many all-stars are the Redbirds gonna have?(44:40-58:30) Disclosure Days. Movie Boi gives it 4/5 popcorns. Woke propaganda. Martin dabbles in yellow journalism. Why won't Jackson watch Girl Next Door? Radio silence from McGreevy on the D May front. Crashing weddings.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Summary: In this episode, Justin Townsend and Adam Berkelmans explore the history, techniques, and safety considerations of fat-based preservation methods like confit, rillette, and oil preservation. They discuss how these ancient techniques transform food and remain relevant today. - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Leave a Review of the Podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Buy our Wild Fish and Game Spices⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Art of Venison Sausage Making⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Links: A Hunter's Guide to Confit Venison Shank Confit Chapters: 00:00 Introduction and Overview of Fat Preservation Techniques 02:50 The History and Evolution of Confit 06:02 The Science Behind Confit and Preservation 08:56 Rendering Fat: The Key to Successful Confit 11:51 Practical Applications and Modern Considerations 22:02 Unlocking the Value of Animal Fats 25:30 Exploring Confit and Rillette Techniques 30:04 Innovative Oil Preservation Methods 34:10 Safety in Fat and Oil Preservation 41:10 The Luxurious Transformation of Food Preservation Takeaways: History of confit and fat preservation Techniques for rendering and preserving fat Safety considerations and botulism risks Modern applications of traditional methods Transformative effects of fat on food texture and flavor Keywords: Food preservation, confit, rillette, fat preservation, wild food, traditional techniques, safety, botulism, rendering fat, culinary history Learn more about your ad choices. Visit megaphone.fm/adchoices

Everyone wants to know how "bounce back" after having a baby. The truth is, that's not the goal. In this episode, I'm sharing my postpartum fitness plan and the approach I'll be taking during those first weeks and months after birth. Instead of jumping straight into workouts, fat loss, or trying to get my body back as quickly as possible, I'll be prioritizing recovery, sleep, healing, and listening to what my body actually needs. I'll walk you through what my first few weeks postpartum may look like, including why I plan to spend most of the first week resting, when I might begin incorporating light walks and mobility work, and how I'll use my body's feedback, not a rigid timeline, to guide the process. We'll also talk about why pelvic floor health is at the center of my recovery plan and why I believe every woman should consider working with a pelvic floor physical therapist before problems arise, not just after. I'll share why I won't be rushing back into intense cardio, despite the pressure many women feel to lose baby weight as quickly as possible. We'll also discuss the truth about waist trainers, why external support can actually delay core recovery, and what a healthier approach to rebuilding strength looks like. Most importantly, I'm talking about something I think every new mom struggles with: comparison. Because no two postpartum journeys are the same, and comparing your recovery, body, or timeline to someone else's is one of the fastest ways to create unnecessary stress and frustration. If you're pregnant, postpartum, or simply curious about a more sustainable approach to recovery after birth, this episode will give you an honest look at how I'm thinking about this next chapter and why slower may actually be the smarter path forward.   Time Stamps:   (2:11) My Postpartum Fitness Plan (3:22) The Mental Side (9:19) Getting Your Body “Back” (11:20) Comparison In Postpartum (13:32) Sharing The Postpartum Journey --------------------- Find Out More Information on Vital Spark Coaching --------------------- Follow @vanessagfitness on Instagram for daily fitness tips & motivation.  --------------------- Download Our FREE Metabolism-Boosting Workout Program --------------------- Join the Women's Metabolism Secrets Facebook Community for 25+ videos teaching you how to start losing fat without hating your life! --------------------- Click here to send me a message on Facebook and we'll see how I can help or what best free resources I can share! --------------------- Interested in 1-on-1 Coaching with my team of Metabolism & Hormone Experts? Apply Here! --------------------- Check out our Youtube Channel! --------------------- Enjoyed the podcast? Let us know what you think and leave a 5⭐️ rating and review on iTunes!

Is retatrutide, the new triple agonist GLP-1, the next big thing in weight loss (or even rapid fat loss)?That depends on how the drug works, what the results are, the reality between the headlines and the evidence, and what happens to your weight when you stop.This episode breaks down retatrutide, the GLP-1, GIP, and glucagon triple agonist behind the largest weight loss numbers ever recorded in this class. It covers the Phase 2 obesity trial and the Phase 3 Triumph results, plus why cross-trial comparisons to semaglutide and tirzepatide deserve skepticism.We examine the body composition data (or lack thereof), and why a bigger number on the scale just amplifies the stakes for muscle mass, weight regain, and the off-ramp. Especially relevant for adults over 40 who are taking, considering, or planning to come off a GLP-1.Enroll in Eat More Lift Heavy, the 26-week coached program where adults over 40 build the nutrition and training skills to preserve muscle, lose fat, and manage their physique for life, including support for lifestyle changes needed while taking GLP-1s (and to come off them if desired).Timestamps:0:00 - Retatrutide and the biggest question for GLP-1 users 3:08 - How this new triple agonist works 4:46 - Phase 2 and Phase 3 weight loss numbers 5:38 - Cross-trial comparisons and their limits 6:23 - Fat, muscle, and what the trial did NOT measure 8:30 - Strength training over 40 and accelerated muscle loss 10:07 - Building the lifestyle (alongside using the drug) 14:10 - Resistance training and protein 16:00 - Rate of loss on a powerful drug like retatrutide 17:30 - The off-ramp when you stop 18:23 - Weight regain and body fat overshooting 22:03 - Retatrutide access and the gray market 24:11 - Bonus: 3-question test to keep your resultsEpisode Mentioned:Sometimes More Is More (The Sedentary Lifter Problem)

The internet is increasingly pushing the idea that people are powerless over their weight, claiming obesity is almost entirely biology, discipline is an illusion, and hunger always wins. While biology, hormones, sleep, stress, medications, and environment absolutely influence behavior, influence is not the same as control. The problem with this messaging is that it often turns awareness into helplessness, causing people to stop believing change is possible before they even try.Fat loss is difficult, but humans are uniquely capable of building habits, creating structure, managing their environment, and overriding impulses over time. The most successful people consistently practice basic behaviors like eating enough protein, exercising regularly, improving sleep, and monitoring their intake.Biology is the context, not the conclusion, and while it may make the journey harder for some than others, believing you have no control ultimately removes your ability to change.In this episode, we break down where these ideas come from, what they get right, and where they go too far.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/Over the last 15 years, I've built companies and spent millions testing what actually upgrades human performance, and I can tell you that mental fatigue has absolutely nothing to do with willpower. In this video, I break down the exact neurochemistry of deep focus. When your brain runs out of dopamine, norepinephrine, and acetylcholine, or gets bogged down by oxidative stress, your executive function collapses. The pharmaceutical industry wants you hooked on expensive stimulants that only treat the symptoms, but the real biological fix is a common antioxidant: Vitamin C.I explain how your brain hoards Vitamin C at levels 100 times higher than your blood, how to bypass the blood-brain barrier using SVCT2 transporters, and why eating sugar before you take it completely blocks its absorption. You'll also learn the exact biohacking stack—including NAC, CoQ10, PQQ, and L-theanine—you need to recycle this molecule, protect your mitochondria, and maintain effortless, razor-sharp focus all day long.Thank you to our sponsors!-KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Trailer00:21 – Focus Is Biology01:53 – Brain Chemistry Explained05:33 – Vitamin C Revealed07:09 – How to Dose08:18 – Absorption Barriers09:31 – Optimize Uptake10:00 – Oxidative Stress Problem11:00 – Stack for Deeper FocusConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

We've got some feedback on the white suit Fat wore to the footy last night; A very special guest walks into the room to put on Ch7 Pin on Damo; We're joined by Geelong's Mark O'Connor and Melbourne's Max Gawn; and there is Nuff and a questionable QuizSee omnystudio.com/listener for privacy information.

Semaglutide Slows Biological Aging A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigenetic clock in adults living with HIV-associated metabolic disease, with simultaneous improvements across inflammation, heart, kidney, liver, and brain markers. Host Dave Asprey breaks down why this isn't a weight loss story. It's a metabolic inflammation story. He explains why the GLP-1 mechanism hitting insulin signaling, oxidative stress, and inflammatory pathways simultaneously is the real finding, and makes the case that your metabolic markers and your aging markers are the same numbers. Sources: https://www.medicalnewstoday.com/articles/glp-1-drugs-ozempic-wegovy-may-slow-biological-aging https://www.nature.com/articles/s41467-026-72861-3 https://today.ucsd.edu/story/study-popular-glp-1-drug-may-slow-down-biological-aging FDA Approves First New Sunscreen Ingredient in 20 Years The FDA approved bemotrizinol as a permitted OTC sunscreen active ingredient, the first new approval in roughly two decades, clearing it for adults and children six months and older with broad UVA and UVB coverage and low skin absorption. Host Dave Asprey explains why twenty years of regulatory lag left American consumers with inferior chemistry while Europe moved on, why he's watching independent absorption data before updating his own stack, and why consistency of use matters more than perfect formulation when sun protection remains one of the most evidence-backed longevity interventions available. Sources: https://www.fda.gov/news-events/fda-newsroom/press-announcements/fda-expands-sunscreen-options-first-time-20-years https://www.accessdata.fda.gov/scripts/cder/omuf/index.cfm?event=OrderDetail&orderid=OTC000039 https://www.usatoday.com/story/news/health/2026/06/09/new-sunscreen-ingredient-bemotrizinol/90477659007/ Deoxyribose Gel Matches Minoxidil in Hair Regrowth Study Researchers testing a topical gel made from deoxyribose, the sugar backbone of DNA, saw roughly 80 to 90 percent hair regrowth in a mouse model of male-pattern baldness, matching minoxidil results and showing new follicle formation and increased blood vessel activity in treated areas. Host Dave Asprey breaks down why mouse hair regrowth studies have a long history of failing to translate to humans, what a plausible circulation-based mechanism would actually need to show in human trial data before it's worth acting on, and why the molecule itself is interesting enough to keep watching. Sources: https://www.reddit.com/r/Biohackers/comments/1tyt87w/researchers_found_that_a_gel_made_from/ https://www.sciencealert.com/surprise-hair-loss-breakthrough-a-dna-sugar-gel-sparks-robust-regrowth Caffeinated Chewing Gum and Exercise Performance A systematic review and meta-analysis of 21 studies found caffeinated chewing gum produces a small but real ergogenic effect for muscular strength and countermovement jump height, with buccal absorption delivering caffeine faster than capsules or drinks in a five to twenty-five minute pre-training window. Host Dave Asprey breaks down why delivery mechanism is an underrated variable in caffeine optimization, why timing matters as much as dose, and why a modest but measurable edge on a cheap and accessible tool is exactly the kind of practical biohack worth understanding. Sources: https://pubmed.ncbi.nlm.nih.gov/42228847/ https://doi.org/10.1519/JSC.0000000000005530 https://www.reddit.com/r/Biohackers/comments/1u0acgc/fastacting_caffeine_does_caffeinated_chewing_gum/ Vitamin A Overdoses Surge Nearly 40 Percent Medical News Today reported a 38.7 percent spike in vitamin A overdoses in early 2025, driven by online misinformation claiming high-dose vitamin A treats or prevents measles, a claim with no clinical support and real toxicity risk from fat-soluble accumulation in the liver. Host Dave Asprey explains the actual hepatotoxicity and bone demineralization risks of preformed retinol excess, draws the critical distinction between preformed retinol and beta-carotene that got lost in the misinformation cycle, and makes the case that mechanism is not a dosing protocol and confusing the two is how people get hurt. Sources: https://www.medicalnewstoday.com/amp/articles/vitamin-a-overdoses-rose-by-38-7-2025-how-to-get-right-amount World Cup 2026 and Mass Gathering Health Risk With the 2026 FIFA World Cup underway, public health researchers are flagging dense international crowds, high-volume travel, and shared indoor and outdoor spaces as an elevated transmission environment for respiratory illness. Host Dave Asprey reframes the conversation away from germ exposure and toward immune terrain, explains why your resilience going into a high-contact environment is a variable you actually control, and lays out the pre-exposure preparation window that matters most for anyone traveling or attending large events this summer. Sources: https://www.healthline.com/health-news/2026-fifa-world-cup-health-risks-protect-yourself This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on GLP-1 aging biology, sunscreen chemistry and regulatory science, emerging hair regrowth research, caffeine delivery optimization, supplement toxicity risk, and immune terrain preparation for mass gathering events. Host Dave Asprey connects randomized clinical data, epigenetic clock research, consumer health regulation, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: semaglutide biological aging, GLP-1 epigenetic clock, DunedinPACE aging marker, PCGrimAge mortality risk, bemotrizinol FDA approval, new sunscreen ingredient 2026, UVA UVB broad spectrum sunscreen, deoxyribose hair gel, minoxidil alternative hair regrowth, caffeinated chewing gum performance, buccal caffeine absorption, pre-workout caffeine timing, vitamin A overdose toxicity, preformed retinol hypervitaminosis, fat-soluble vitamin accumulation, World Cup 2026 health risk, immune terrain optimization, mass gathering respiratory illness, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:41 – Story 1: Ozempic Slows Aging Clocks 01:53 – Story 2: New Sunscreen Approved 03:12 – Story 3: DNA Sugar & Hair Regrowth 04:38 – Story 4: Caffeine Gum & Performance 06:13 – Story 5: Vitamin A Overdose Spike 07:59 – Story 6: World Cup & Immune Prep 09:34 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week, we're joined by STgenetics®' Kevin Ziemba to discuss his article, "The Story of Fat and the Future of Protein: How Genetics Influence Components." We explore how changing consumer preferences are shaping processor demands, influencing genetic selection decisions on dairies worldwide, and creating new opportunities for producers to capture more value through strategic breeding programs. Tune in to learn why protein may be the next frontier in dairy genetics.

How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him. Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. . You'll Learn: Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one How to physically grow your hippocampus through exercise, meditation, and nutrition Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like The 7 everyday things that are shrinking your brain right now How stress, loneliness, and isolation cause measurable brain atrophy Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health Why VO2 max predicts brain aging better than almost any other marker What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely Why mitochondria health is the foundation of both brain function and longevity Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Pique | Go to Piquelife.com/dave for 20% off. - BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance Resources: • Learn More About Dr. Fotuhi's Work At: https://drfotuhi.com/ • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:59 – Intro 03:00 – Cannabis & Nicotine 04:15 – Understanding Alzheimer's 05:38 – Five Pillars Explained 07:55 – Best Cognitive Training 09:08 – Brain Size & Growth 12:36 – B12 & Lab Ranges 17:48 – Head-to-Toe Evaluation 24:17 – Sex & Brain Health 25:43 – Loneliness & Isolation 33:59 – ApoE4 Genetics 35:28 – Alzheimer's Declining 48:44 – Lithium & Brain 59:38 – VO2 Max & Fitness 1:06:42 – Psychedelics 1:09:38 – GLP-1s & Brain 1:12:38 – Closing & Action Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The protein shake Ben uses is Equip Foods Prime Protein (20% off, code BENAZADI):  https://bit.ly/4xzZI78  Pre-order Keto Flex Revised, out July 21st, and get free bonuses: https://bit.ly/4wKG1sM    Your belly fat isn't dead weight sitting around your waist. It's a biologically active organ, and the deep visceral fat around your organs sends inflammatory signals straight to your brain. Those signals shape your cravings, your mood, your memory, and your ability to feel full. One 2024 study found that people in their 20s and 30s with high visceral fat had nearly six times the risk of brain shrinkage. The late-night food noise and the willpower that keeps failing you aren't a character flaw. They're a broken biological signal. The good news: a 2026 study from Professor Iris Shai's team and Harvard showed that when people lost visceral fat and kept it off, brain shrinkage slowed and memory held strong into their 60s. This reverses. Key takeaways: Fat tissue is an endocrine organ, in the same category as your thyroid and adrenals Visceral fat, not the fat you can pinch, is the metabolically dangerous kind Leptin resistance is involved in roughly 90 percent of obesity cases, so it's a signaling problem, not a willpower problem Food noise is neurological: obesity lights up the same brain reward center as drug addiction Visceral fat is linked to depression and anxiety, independent of overall body weight Losing deep abdominal fat specifically, not just pounds, protects the brain, even against the APOE Alzheimer's gene 30 grams of protein per meal triggers your body's own GLP-1 and quiets cravings for free Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

Your eyes might be revealing metabolic disease long before your doctor catches it in bloodwork — and most people have no idea. In this episode, Dr. Vera Tarman sits down with Dr. Radka Toms, ophthalmologist, functional medicine practitioner, and founder of My Sugar Stop, to explore the fascinating and largely unknown connection between sugar, gut health, and your vision. Dr. Toms shares her own story — from a "hardcore conventional doctor" eating chocolate bars for lunch to developing rosacea and insulin resistance and eventually pioneering the field of nutritional ophthalmology. What You'll Learn:

Burn Fat While You Sleep, Boost Metabolism & Fast the Smart Way with guest expert Dr. William Li #64What if everything you've been told about metabolism, fat, and weight loss is wrong? In this episode, Samantha sits down with Dr. William Li for a second conversation in season 2 (Check out Episode #62, if you missed it - and Season 1 Episode #14 as well!).Dr. Li dismantles everything you thought you knew about metabolism, visceral fat, and intermittent fasting — revealing the science-backed strategies that let your body burn dangerous fat while you sleep, eat, and live your life.Dr. Li is an internationally renowned physician-scientist, president of the Angiogenesis Foundation, and New York Times bestselling author of Eat to Beat Your Diet — to expose the myths that have kept so many women stuck in a cycle of dieting, frustration, and self-blame.Spoiler: your metabolism is not broken. It never was.From the newly discovered science proving that human metabolism stays rock-stable from age 20 to 60, to the hidden danger of "skinny fat" and its shocking link to breast cancer, to the brilliantly simple 12-hour fasting protocol Dr. Li himself follows every day — this episode is a masterclass in working with your body instead of against it. Plus, the true origin story of the famous 16:8 intermittent fasting method that no one is talking about.WHAT YOU'LL LEARN:Your metabolism is NOT slowing down: Learn the findings from a landmark study of 6,000 people that completely rewrites what we thought we knew about metabolism — and where the real culprit actually lives.Fat is a hormone-producing organ: Discover why healthy fat is essential to your metabolic function, and what happens to your hormones when it starts to grow out of control.Excess fat behaves like a tumor: Find out why Dr. Li says too much body fat follows the same dangerous playbook as cancer — and why that makes chronic inflammation so much more urgent to address.Skinny fat is a real and serious risk: Learn what a 13-year Cornell study found when it scanned nearly 3,500 normal-weight women — and why the results are a wake-up call for women who think they're in the clear.Foods that burn fat at the cellular level: Discover which everyday grocery store foods contain natural bioactives that work against fat growth — and how they do it without you changing everything on your plate.The tape measure test: Find out why your waistline tells a more accurate story about your health than your BMI, your scale, or your body size — and how to use it at home for free.Why 12 hours of fasting is enough: Learn the surprisingly achievable protocol Dr. Li follows himself every single day — and why the research says you don't need to go longer to see real results.The truth about 16:8: Discover the origin story of the most popular intermittent fasting method — and why its famous time window has almost nothing to do with human science.Insulin is the metabolic switch: Understand the simple biological reason your body burns fat while you sleep — and how the timing of your last meal determines how hard it works overnight.Ultra-lean is not ultra-safe: Find out why the medical literature puts extreme leanness in the same dangerous category as extreme obesity — and what that means for how we define a healthy goal.About Our GuestDr. William Li is an internationally renowned physician, scientist, researcher, and author whose work has impacted over 70 diseases, including cancer, diabetes, and cardiovascular disease. He is the founder and president of the Angiogenesis Foundation and is best known for his groundbreaking TED Talk, Can We Eat to Starve Cancer?, which has been viewed by millions worldwide. He is the New York Times bestselling author of Eat to Beat Disease and Eat to Beat Your Diet: Burn Fat, Heal Your Metabolism, and Live Longer.

You HAVE to see this — Karmelo Anthony sobbing in court after being sentenced to 35 years in prison for the cold-blooded murder of Austin Metcalf at a Texas high school track meet. Pat Gray breaks down the shocking verdict, the victim's family's powerful statements, and the hate-filled racial protests that erupted outside the courthouse as Anthony's supporters screamed “Free Karmelo!” and called the entire trial racist. This wasn't self-defense. Anthony was asked to move 15 times, warned Metcalf “touch me and find out,” then stabbed the 17-year-old peacemaker straight in the chest. The jury saw through the excuses, rejected the “sudden passion” defense, and delivered real justice in one of Texas' most conservative counties. We also cover: SPLC president defends Graham Platner? McDonald's about to release “Archy” AI drive-thrus. TrumpRX just added 800 MORE medications.  Dr. Alveda King DESTROYS Jamie Raskin in fiery showdown. WNBA's Brianna Turner questions wearing the “USA 250” patch. I'm reading every single comment from patriots like you. Drop your hottest take and let's stand together for real justice and accountability. If you're tired of the media pushing excuses for violent crime while ignoring innocent victims like Austin Metcalf, smash that LIKE button, SUBSCRIBE, and turn on notifications so you never miss Pat's unfiltered truth. 00:00 Pat Gray UNLEASHED! 00:36 Karmelo Anthony Guilty Verdict 03:11 Outside the Karmelo Anthony Trial 04:36 Fox News Announces Karmelo Anthony Verdict 06:22 Court TV Has a Meltdown over Karmelo Anthony Verdict 08:04 More of Upset People Outside the Karmelo Anthony Trial 13:14 We Have a Chasm! 17:34 Pat Gray BINGO! Winner 19:08 Graham Platner Officially Nominated 19:52 AOC on Graham Platner 21:22 Graham Platner Recruited by Two Socialists 25:15 SPLC President Asked about Graham Platner 26:30 SPLC President Asked about Pro-Life Advocates 31:39 Chewing the Fat 45:49 Brendan Sorsby Situation 48:17 Expansion of TrumpRx 51:19 SPLC President VS. Chip Roy 53:19 SPLC President VS. Darrell Issa 54:58 Jim Jordan on SPLC / Biden Administration Connection 55:55 Jim Jordan on SPLC Pocketing Money 58:14 Alveda King's Opening Remarks 1:00:15 Alveda King VS. Jamie Raskin 1:01:20 Jasmine Crockett Belittles Alveda King 1:02:04 Jasmine Crockett Attacks Charlie Kirk Post-Mortem 1:04:00 Wesley Hunt Claps Back against Jasmine Crockett 1:07:15 Trump on Iran's Power Plants & Bridges 1:08:36 Drone Boat Rescue of Two U.S. Pilots 1:12:24 Walton Family on Fox News 1:14:26 WNBA has Issues with U.S.A. 250 Jersey Patch 1:18:43 AI-Generated James Talarico Ad 1:19:40 John Thune Asked about the SAVE Act 1:22:51 How Spencer Pratt Lost the LA Mayoral Race? 1:28:32 DC Reflecting Pool Timelapse 1:32:40 Lee Zeldin Stopping Animal Testing? Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 2812 - Vinnie Tortorich and Chris Shaffer discuss food dyes and disease, what their effects could be, and much more. https://vinnietortorich.com/2026/06/food-dyes-and-disease-episode-2812 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Vinnie's workout videos are available to purchase! Choose from a 2-day, 4-day, or 6-day workout–or buy all three at a discount! TO PURCHASE VINNIE'S WORKOUT VIDEOS, CLICK THIS LINK: https://vinnietortorich.com/workout Food Dyes and Disease Ideas to boost protein. (5:00) There is a side quest discussion regarding yachts, private jets, and helicopters. (16:00) Food dyes are being removed from some Jell-Os. (26:00) A hundred thousand participants in a French study said that food coloring additives, even natural ones, increase the risk of chronic disease. (29:00) Findings suggest that even natural food colorings can increase the risk of diabetes and even cancer. It's not necessarily about the food coloring, but also the crap food they go into, like sugary cereals. (31:00) "Fat-free" foods are often loaded with more sugar and sweeteners. (39:15) Also, natural food dye in a generally unhealthy food doesn't make it any better for you. The NOVA definitions of ultra-processed foods originated in Brazil. (40:30) Brazil is moving to ban ultra-processed foods from both hospitals and schools. The food at those two places must be freshly prepared. Vinnie shares a story about his shoulder surgery and how being NSNG helped his healing, because NSNG can help reduce inflammation. (42:00) ALSO: Anna's products are now linked to PureVitamin Club's website. Look under the "Food and Snacks" section to purchase them there, too. (58:30) https://purevitaminclub.com/collections/food-and-snacks The NSNG® VIP GROUP IS NOW CLOSED AGAIN AS OF SUNDAY, MARCH 15TH Anna's next cookbook, Eat Happy Cocktail Hour, is filled with cocktails, mocktails, and appetizers and is available for pre-order right now. If you pre-order, you'll get bonus goodies! You can preorder from a wide variety of booksellers at https://eathappycocktailhour.com/ Save your receipt from wherever you preorder, you'll need it for your bonuses! Physical Release Date is October 2026 A New Sponsor Jaspr Air Scrubbers has a discount code, VINNIE, that gets you $200 off for a limited time. Jaspr offers a lifetime warranty. Go to Jaspr.co for more information or to purchase. (1:05:00) You can book a consultation with Vinnie to get guidance on your goals. https://vinnietortorich.com/phone-consultation-2/ More News Serena has added some of her clothing suggestions and beauty product suggestions to Vinnie's Amazon Recommended Products link. Self Care, Beauty, and Grooming Products that Actually Work! https://www.amazon.com/shop/vinnietortorich/list/3GPVU29UHHPMY?ref_=aipsflist Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Please make sure to watch, rate, and review it! Eat Happy Italian, Anna's second cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, on her website, and on Substack —they will spice up your day! https://annavocino.substack.com/ PURCHASE DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views it receives, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries

Send us Fan MailI am sharing my top five tips for the best sleep! I recently got a 99 sleep score and my sleep has been so good.Since tracking my sleep, I have really been able to figure out what is working, what keeps my score high, and what has been tanking it. This is such an important topic for our health. Because so much regeneration and repair happens while we sleep, I thought sleep deserved its own episode!Let me know if you have any questions or feedback. As always, you can send me an email or a DM on Instagram. Mouth Tape: Click Here  JESSICAITURZAETA15  for 15% offFind Jess below!Website: Simply Jess Skincare SIMPLY JESS SKINCARE:Each and every product is naturally derived, highly concentrated and most importantly, super performing! Every product was born out of a need to have a truly pure product that met my high standards for efficacy. Subscribe to Our Newsletter! You can take 20% off Your Order of our all natural skincare line with code: PODCAST Shop Now! Favorite Supplements for Health and Fat loss: Click HERE  My favorites are the Power Greens, Digestive Enzymes and Brain Power Favorite Mouth and Face Tape- Use Code JESSICAITURZAETA15 for 15% off Click Here Mushroom Coffee-15% off with Code: SIMPLYJESSSKINCARE15 Click HereEmail Us! jess@learningtoglow.comFollow us! Instagram Tik Tok

Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your blood vessels hold the real key to biological aging. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. William Li, an internationally renowned physician, scientist, and two-time New York Times bestselling author of "Eat to Beat Disease" and "Eat to Beat Your Diet." As President and Medical Director of the Angiogenesis Foundation, Dr. Li's groundbreaking research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases including diabetes, heart disease, blindness, and obesity. His TED Talk, "Can We Eat to Starve Cancer?", has surpassed 11 million views, making him one of the most trusted voices at the intersection of functional medicine and food as medicine science. Together they dig into the biology of SuperAgers, the vascular markers that predict how long you'll live, and why flow-mediated dilation may be the most underrated biohacking measurement tool available today. Dave shares what happened after four separate gene therapies, including klotho and VEGF, and Dr. Li explains why your metabolism, mitochondria, and gut microbiome show up in the data on every centenarian ever studied. They also get into the microplastic crisis, the cribriform plate pathway that delivers airborne particles directly to your brain, and why your tongue is the first place your body quietly stores fat. You'll Learn: What centenarian research reveals about immune function, gut health, and vascular resilience Why 50% of food extracts matched or outperformed cancer drugs in head-to-head angiogenesis testing How microplastics travel through your nose directly to your central nervous system What flow-mediated dilation and pulse wave velocity tell you about your true biological age Why your hind-third tongue fat is an overlooked early warning sign for sleep apnea and metabolism problems What Dave's four gene therapies (klotho, VEGF, follistatin) actually did to his body How the vagus nerve connects gut health to brain optimization, stress resilience, and longevity Why genetics now accounts for roughly half of longevity outcomes, and what that means for the future of gene therapy How to use biohacking tools to compound your health the same way you compound financial returns Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order. - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: William Li, Dr. William Li, Eat to Beat Disease, angiogenesis, food as medicine, centenarians, SuperAgers, longevity, anti-aging, biohacking, vascular health, flow-mediated dilation, pulse wave velocity, microplastics, cribriform plate, gene therapy, klotho, VEGF, follistatin, mitochondria, metabolism, gut health, vagus nerve, sleep apnea, functional medicine, human performance, brain optimization, cancer prevention, inflammation, immune system Resources: • Learn More About Dr. Li's Work At: https://drwilliamli.com • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 02:33 – William's Background 06:21 – Food vs. Cancer Drugs 14:09 – Gene Therapy 23:50 – Centenarian Research 27:41 – Stress & the Vagus Nerve 37:31 – Vascular Health 42:34 – Microplastics 53:19 – Novel Biomarkers See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Intro; Holidays, Birthdays, Feedbag, Chub Hugs, Nostalgia, What’s In Your Lunchbox?, Hey Chubs, Advice; TV and Movie Reviews, and lots of chub talk! chubsgonewild@gmail.com Subscribe in iTunes! Right Click Here To Download ChubsGW645: Chubs Gone Pride

Coming off GLP-1s before getting pregnant is not as simple as just stopping. Here is what to realistically expect.In this episode:What the clinical guidance says about when to stop GLP-1s before trying to conceive or starting fertility treatmentWhat to expect physically when you stop, including the truth about weight regain that nobody is preparing you forHow to take care of your body, your cycle, and your mental health through this transitionWeight regain after stopping GLP-1s is clinically expected and not your fault. Your body is not broken. It is doing exactly what the research says it will do, and you deserved to know that before you ever started taking this medication.Resources:Book a Fat Positive Fertility Roadmap SessionGet the book: Fat and FertileHave questions? Share your story in the Substack comments. I would love to hear from you. Get full access to Fat and Fertile at fatpositivefertility.substack.com/subscribe

Dani Conway is a Functional Nutritionist specializing in hormone health, gut healing, and sustainable weight loss for women over 40. Through advanced testing and personalized wellness strategies, she helps women uncover root causes, restore vitality, and achieve lasting health. Connect with Dani: The Wellness Collective: https://nutritionthenaturalway.com/ Midlife Metabolism Guide: https://go.nutritionthenaturalway.com/hhh Instagram: @daniconwayofficial The Weight Loss Accelerator: Drop the Weight, Shred the Fat  

What if the amount of exercise you actually need for long-term health is far less than you've been led to believe? In this episode, I'm breaking down some fascinating claims from longevity expert Dr. Amy Killen that completely challenge the "more is better" approach many women have been taught when it comes to fitness. One statistic in particular caught my attention: her claim that women may achieve most of the longevity benefits of resistance training with surprisingly little weekly volume. We'll dive into what the research actually says about strength training, longevity, and mortality risk, including why multiple studies seem to show that the biggest health benefits occur at relatively modest amounts of resistance training. I'll also share why, in my own experience and in working with clients, two to three strength-training sessions per week seems to be the sweet spot for recovery, consistency, and long-term results. We'll talk about the trap of comparing yourself to genetic outliers, influencers, and fitness competitors whose training volumes often aren't realistic or necessary for the average woman. I'll also unpack the recommendation of 150 minutes of moderate aerobic exercise per week, why walking may be one of the most powerful longevity tools available, and my thoughts on where high-intensity exercise fits into the picture. Most importantly, I want to make the case that prioritizing health often leads to better physique outcomes over the long term than constantly chasing more workouts, more volume, and more intensity. We'll also discuss the real risks of overtraining, including hormone disruption, cycle irregularities, bone loss, and the cumulative stress excessive exercise can place on the body. If you've ever felt like you're falling behind because you're not doing enough, this episode might be the permission slip you need. Sometimes the path to better health, better recovery, and a better body isn't doing more. It's doing the right things consistently for years.   Time Stamps:   (3:02) Being Prepared For Baby Girl   (4:26) Women's Needs For Exercise   (8:22) Going Against The Stereotypical Advice   (12:37) Prioritizing Health Goals   (17:42) House Analogy   (20:07) HIIT Training --------------------- Find Out More Information on Vital Spark Coaching --------------------- Follow @vanessagfitness on Instagram for daily fitness tips & motivation.  --------------------- Download Our FREE Metabolism-Boosting Workout Program --------------------- Join the Women's Metabolism Secrets Facebook Community for 25+ videos teaching you how to start losing fat without hating your life! --------------------- Click here to send me a message on Facebook and we'll see how I can help or what best free resources I can share! --------------------- Interested in 1-on-1 Coaching with my team of Metabolism & Hormone Experts? Apply Here! --------------------- Check out our Youtube Channel! --------------------- Enjoyed the podcast? Let us know what you think and leave a 5⭐️ rating and review on iTunes!

Belly fat is one of the most searched health topics online. And honestly, that's not surprising. So many women are frustrated because they've tried everything they can think of and still aren't seeing the results they want. The problem is that the fitness industry has become incredibly good at selling quick fixes. Detox teas. Fat-burning supplements. Waist trainers. Thirty-day challenges. Cutting out entire food groups. The latest "secret" method that promises to melt belly fat fast. But here's the question: If those things actually worked long-term, would you still be searching for answers? Probably not. The truth is, most of those approaches create temporary results at best. They leave you feeling frustrated, discouraged, and wondering what's wrong with you when the weight comes back or never leaves in the first place. So today, I want to talk about the truth. No gimmicks. No magic tricks. No sugarcoating. Just the truth about what it really takes to lose belly fat and improve your health. Because if you're serious about seeing lasting results, there are some things you're going to have to stop doing. There are also some things you're finally going to have to start doing consistently. Now, that doesn't mean starving yourself, spending hours in the gym, or living on salads for the rest of your life. It means focusing on the habits that actually move the needle and letting go of the things that keep you stuck in the cycle of starting over. So if you're tired of wasting time on shortcuts and you're ready to focus on what truly works, stick with me because we're going to cover it all today. And if you're listening and thinking, "I know what I need to do, but I need accountability and support," I'd love to help. I offer one-on-one coaching where we work together to create a sustainable approach that fits your life. You can reach me at TaraJ@dietditching.com. And I'd also love for you to join our Facebook community, Lose Weight, Live Free, where you'll find encouragement, support, and other women who are working toward lasting freedom with food, weight, and health.

A headline like “weight loss drugs may reduce breast cancer risk” grabs attention fast, but the real story lives in the fine print. We take you through a new Penn Medicine study that observed lower breast cancer rates among women with overweight or obesity who used GLP-1 medications, then we translate what that finding actually means in plain language. Observational data can reveal a signal worth studying, but it cannot prove the medication caused the outcome, and that distinction matters for your decisions and your expectations. We also zoom out to the bigger why: obesity is not just about body size. Fat tissue is biologically active, shaping chronic inflammation, estrogen exposure after menopause, insulin resistance, and even how well the immune system spots abnormal cells. Those pathways help explain why obesity is linked to many cancers, including postmenopausal breast cancer, and why researchers are curious whether effective obesity treatment could shift risk over time. Then we get practical. We review what stronger evidence from randomized controlled trials says so far: GLP-1 drugs like Ozempic, Wegovy, Mounjaro, and Zepbound do not appear to increase breast cancer risk in the available trial data, even though most trials were not designed to study cancer outcomes for many years. We also discuss why newer studies seem most suggestive for hormone receptor positive breast cancer, along with the leading theories: weight loss itself, improved metabolic health and insulin signaling, reduced inflammation, and the still-unclear possibility of direct GLP-1 effects in cancer biology. If you like evidence-based medicine with real-world context (and a little Philly-life banter), subscribe, share this episode with a friend, and leave a review so more people can find the show. What question do you want answered next about GLP-1s, obesity treatment, or cancer risk?ReferencesRisk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists : A Systematic Review and Meta-Analysis. Ko A, Chang YC, Bahar F, et al. Annals of Internal Medicine. 2025;. doi:10.7326/ANNALS-25-02237.Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-Analysis. Piccoli GF, Mesquita LA, Stein C, et al. The Journal of Clinical Endocrinology and Metabolism. 2021;106(3):912-921. doi:10.1210/clinem/dgaa891.Glucagon-Like Peptide 1 Receptor Agonists and Cancer Risk: The Good, the Bad and the Unknown. Mannucci E, Dicembrini I. Nature Reviews. Clinical Oncology. 2026;23(6):459-470. doi:10.1038/s41571-026-01135-0.GLP-1 Agonists Are Associated With a Significant Reduction in Breast Cancer Incidence in Women. McDonald ES, Gillis LB, Gabriel P, et al. JCO Oncology Practice. 2026;:101200OP2600485. doi:10.1200/OP-26-00485.GLP-1 therapy and hormone receptor–positive breast cancer risk and survival: A real-world analysis.. Shah Z, Hundal J, Afridi S, et al. Journal of Clinical Oncology. 2026;44(Suppl 16):10548. doi:10.1200/JCO.2026.44.16_suppl.10548.Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer. Tatum KL, Dahman B, Stevenson A, et al. JAMA Network Open. 2026;9(5):e2612133. doi:10.1001/jamanetworkopen.2026.12133.Association of Glucagon-Like Peptide-1 Receptor Agonists With Risk of Cancers-Evidence From a Drug Target Mendelian Randomization and Clinical Trials. Sun Y, Liu Y, Dian Y, et al. International Journal of Surgery (London, England). 2024;110(8):4688-4694. doi:10.1097/JS9.0000000000001514.GLP-1 receptor agonists and breast cancer risk in type 2 diabetes.. Guo Cheng and Amanda Ward. Journal of Clinical Oncology. 2025;43(Suppl 16):10557. doi:10.1200/JCO.2025.43.16_suppl.10557.Glucagon-Like Peptide-1 Analogues and Risk of Breast Cancer in Women With Type 2 Diabetes: Population Based Cohort Study Using the UK Clinical Practice Research Datalink. Hicks BM, Yin H, Yu OH, et al. BMJ (Clinical Research Ed.). 2016;355:i5340. doi:10.1136/bmj.i5340.GLP-1 Receptor Agonists and Cancer: Current Clinical Evidence and Translational Opportunities for Preclinical Research. Valencia-Rincón E, Rai R, Chandra V, Wellberg EA. The Journal of Clinical Investigation. 2025;135(21):e194743. doi:10.1172/JCI194743.Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.Support the showProduction and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RNArtwork Rebrand and Avatars:Vantage Design Works (Vanessa Jones) Website: https://www.vantagedesignworks.com/Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qrOriginal Artwork Concept: Olivia Pawlowski

I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 seconds, my severe brain fog lifted, and my metabolism completely shifted.In this video, I break down exactly why adding sugar to your morning coffee is destroying your metabolism, spiking your insulin, and keeping you fat. I explain the hard science behind the alternative: blending "fat cubes" (grass-fed butter) and MCT oil into your coffee. I reveal how this specific combination of butyrate, CLA, and medium-chain triglycerides bypasses traditional digestion to go straight to your liver, instantly converting into ketones for pure brain fuel. You'll learn how eating more fat actually trains your body to burn its own stored fat, allowing me to hit 4.8% body fat at 50 years old with a biological age in my 30s—without hunger, without a 3 PM crash, and without living in the gym.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayViome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – Intro 00:42 – Pancreatic Cancer Halted by Virus Injection 01:44 – Teens & AI Therapy Chatbots 03:13 – GLP-1 Drugs Cut Breast Cancer Risk 04:30 – Russia's $26B Longevity Program 06:18 – Sauna vs. Cold Plunge 09:10 – ClosingConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Pancreatic Cancer Halted by Virus Injection Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's dense biological wall becomes less of an advantage when a virus can replicate inside it directly, and why a measurable response at a safety dose is the kind of early signal that changes how he's watching this field. Sources: https://www.newscientist.com AI Chatbots and Teen Mental Health A new survey shows roughly one in five adolescents and young adults are now going to AI chatbots when they feel sad, anxious, nervous, or stressed, with usage heaviest in the 18–21 range. Host Dave Asprey explains why general-purpose language models designed to be engaging are dangerous as a substitute for real mental health support, why false reassurance from a chatbot may make the pipeline to real care harder to reach, and why this is a health systems story masquerading as a tech adoption story — and what parents need to do about it. Sources: https://www.nbcnews.com GLP-1 Drugs Cut Breast Cancer Risk Penn Medicine published a retrospective analysis of over 111,000 women finding GLP-1 exposure associated with about 35% lower odds of breast cancer in the full cohort and around 30% lower in a matched comparison group. Host Dave Asprey breaks down why this isn't just a weight loss story — it's a metabolic dysfunction story — explains the insulin resistance, inflammation, and hormonal environment mechanisms that may be driving the signal, and makes the case that this finding should be reshaping how oncologists and OBGYNs think about high-risk patients right now. Sources: https://www.pennmedicine.org Putin's $26 Billion Longevity Program The Wall Street Journal reports that Russia has made anti-aging research a Kremlin-level national priority through a $26 billion program including gene therapy, organ bioprinting, and xenotransplantation, led by Putin's daughter Maria Vorontsova and physicist Mikhail Kovalchuk. Host Dave Asprey breaks down what's geopolitical theater, what's legitimately frontier science, and why the real question is whether any findings will make it out to the broader research community or get locked inside a state program. Sources: https://www.wsj.com https://www.france24.com Sauna vs. Cold Plunge A landmark Finnish study tracked over 2,300 men for nearly 21 years and found increasing sauna frequency associated with dramatically lower cardiovascular and all-cause mortality — strongest at four or more sessions per week. Host Dave Asprey settles the debate with the actual data, explains what heat shock proteins and cold shock proteins actually are and why the evidence base behind them is nowhere near equivalent, and calls out the wellness marketing presenting early-stage mouse model research as the cold water equivalent of two decades of human mortality outcomes. Sources: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2521522 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cancer treatment breakthroughs, adolescent mental health and AI, metabolic drivers of disease, geopolitical longevity science, and the real evidence behind popular recovery modalities. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: oncolytic virus pancreatic cancer, engineered virus tumor treatment, AI chatbot teen mental health, adolescent AI emotional support, GLP-1 breast cancer risk, semaglutide cancer prevention, metabolic dysfunction root cause disease, Putin longevity program Russia, New Health Preservation Technologies, anti-aging biotech geopolitics, sauna longevity mortality data, cold plunge cold shock proteins, RBM3 heat shock proteins, sauna vs cold plunge evidence, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today - Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:42 – Pancreatic Cancer Halted by Virus Injection 01:44 – Teens & AI Therapy Chatbots 03:13 – GLP-1 Drugs Cut Breast Cancer Risk 04:30 – Russia's $26B Longevity Program 06:18 – Sauna vs. Cold Plunge 09:10 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this solo episode, Vanessa breaks down the biggest takeaways from her conversation with Daniel R. Moore, Professor of Muscle Physiology at the University of Toronto. This episode is a deep dive into muscle protein synthesis, protein intake, fat loss, aging, and why preserving lean mass is one of the most important factors for long-term metabolic health and body composition. Check out the Protein-Sparing Modified Fasting Library at ketogenicgirl.com and use code VANESSA for 20% off. Vanessa explains: What muscle protein synthesis actually is Why muscle is constantly remodeling Why low-protein dieting can accelerate muscle loss How calorie deficits increase protein requirements Why resistance training is the most powerful muscle-preserving signal The truth about the "protein per meal ceiling" Why whey protein is so effective What anabolic resistance really means Why movement and exercise become increasingly important as we age How menopause impacts muscle loss and metabolic health This episode also explores why muscle is not just aesthetic tissue — it is metabolic, protective, and longevity-promoting tissue. In This Episode Muscle protein synthesis explained Protein turnover & muscle remodeling Why low-protein diets backfire Protein needs during fat loss Resistance training & muscle preservation The protein ceiling debate Whey protein & leucine Anabolic resistance & aging Menopause & muscle loss Protein timing & meal distribution Fat loss vs muscle loss Metabolic health & longevity The PSMF Library is officially live

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body.. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time. They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time. You'll Learn: Why microplastics accumulate inside lysosomes and what sulforaphane does to release them How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin What an in-house study revealed about how and where microplastics actually leave the body How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch How sulforaphane boosts BDNF and neuroplasticity at the cellular level What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - Timeline | Go to timeline.com/dave and you'll get an additional 20% off your first month - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox Resources: • For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:55 – Intro & Context 4:48 – Microplastics & Sulforaphane 12:39 – Broccoli Sprouts Formulation 15:20 – Lab Origin Story 26:01 – Reducing Toxin Exposure 37:06 – Estrogen, Hormones & Berberine 52:46 – Autism, ADHD & Brain Health 59:01 – Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

“I'd  like to propose a toast to the garden, to this beautiful planet, and to the gardener. You know,  some people have gardens, some people don't. But, they need to have a garden because Grandfather used to say, “We are all a garden in the world." So, I give thanks to the garden and the gardener.” —Carlo MontesantiAnd so, we have gathered to the final course in this banquet, Dolce. Dessert. Here at this table, we reflect on inheritance. Returning once more to conversations with Carlo Montesanti, Jessie Jowers, and Arianna Gelpke, this episode lingers on to ask if we can remember landscapes, and if we can do so over a shared meal. What does it mean to grow (food, family, and tradition), in a world that has increasingly been shaped by speed, extraction, automation and touristic ideals? Amidst these changes, what remnants will we be able to conserve? In "Dolce," we continue our walk at Slow Life Family Farm, moving between memory, archaeology and rituals made at the dinner table and reflect on the legacy of slow food—that it is not a cuisine and, maybe even, not exclusive to the romantic imagings of Italian provincial life. Perhaps, it is about the way we attend to Earth and care for its continuity, asking not what we can take from it, but what we can give in return. We also join Arianna at Corzano e Paterno to discuss the process of "reading the grapes" and the factors that influence wine-making. This episode contemplates sweetness as something more than a flavour, as a longing for ways of living that keep us in relation to one another and the land which feeds us. Fat of The Land is a series that asks us what we mean when we look for connection between people and the land. Following a desire for real relation, for deliciousness, and for slowness, each episode traces what happens when we follow this desire. This episode is brought to you by generous sponsorships from Ritū and Terra Elaÿa. Music and sound design in this episode is brought to you from the For The Wild Studio.Thank you to Carlo and Jessie of Slow Life Family Farm and Arianna of Fattoria Corzano and Paterno  for joining us in conversation.BiographiesCarlo Montesanti: Born in Siracusa, Carlo is an esteemed English-speaking guide in Eastern Sicily, known for his work with BBC nature documentaries and Netflix's Chef's Table series.Jessie Jowers: With a passion for the traditional uses of plants, Jessie brings a wealth of knowledge about local crafts, foods, and medicines to our farm's daily life. Arianna Gelpke: Arianna Gelpke is a representative of Fattoria Corzano and Paterno, working in the family farm, and wine, cheese and oil production. She is passionate for nature and working with the land in the pursuit of sustainable agriculture and high-quality artisan produce. Since Wendelin Gelpke purchased Corzano in 1971 and the subsequent addition of Paterno in 1974, the two-hundred-hectare farm has developed along three different lines: wine and oil production, artisanal sheep's cheese production, and “Agriturismo.”Partners RitūFat of The Land is a series about what it means to be in relationship with land, food, and the people who tend both across generations. Ritū was made with the same kind of care; six ancient plants, ground and blended into a morning cup that honors the land it comes from, delivered in a compostable bag that returns to the earth.Ritu built a custom landing page for us and would like to offer For The Wild listeners 25% their first month with a discount code FORTHEWILD25. To order yourself some Ritu, head to: drinkritu.com/forthewild Terra ElaÿaThanks also to Elaÿa for the support of this series. Terra Elaÿa is a sanctuary where ancient ways meet the needs of our time. We emerge at this time of crossroads, standing as a space for the transformation, renewal, and re-enchantment of the human spirit. Located in the heart of southern Italy, we provide a place to come into a deeper relationship with life: to slow down, listen, and restore embodied wisdom.Head to terraelaya.com to learn more upcoming Elaÿa experiences or to host an event.  Support the show

This episode is about more than food. It's about understanding why we reach for certain foods, creating a realistic off-ramp from ultra-processed eating, and giving your body a chance to reset. If you've ever felt like you're doing everything right but still struggling with weight, energy, inflammation, or cravings, this episode is for you.   Citation: Hall, Kevin D., et al. “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake.” Cell Metabolism, vol. 30, no. 1, 2019, pp. 67–77.e3. https://doi.org/10.1016/j.cmet.2019.05.008 — This is the cornerstone. Same calories, sugar, fat, fiber, and macros on both diets; people ate ~500 kcal/day more on the ultra-processed one and gained weight. It's the strongest evidence that the processing, not just the nutrients, changes intake. Why fat + sugar together hijack reward more than either alone (the “hyperpalatable” mechanism) DiFeliceantonio, Alexandra G., et al. “Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward.” Cell Metabolism, vol. 28, no. 1, 2018, pp. 33–44.e3. https://doi.org/10.1016/j.cmet.2018.05.018 McDougle, Molly, et al. “Separate Gut-Brain Circuits for Fat and Sugar Reinforcement Combine to Promote Overeating.” Cell Metabolism, vol. 36, no. 2, 2024, pp. 393–407. https://doi.org/10.1016/j.cmet.2023.12.014 — Together these support your point that engineered fat-plus-sugar foods (the Doritos idea) light up reward pathways more than natural foods, because fat and sugar run on separate gut-brain circuits that combine. Why “glycemic velocity” matters — hidden refined starches like maltodextrin Hofman, Denise L., et al. “Nutrition, Health, and Regulatory Aspects of Digestible Maltodextrins.” Critical Reviews in Food Science and Nutrition, vol. 56, no. 12, 2016, pp. https://doi.org/10.1080/10408398.2014.940415 — Supports the egg-bite/maltodextrin point: maltodextrin is a refined starch with a glycemic index around 85–110, higher than table sugar, hiding on labels as “modified food starch.” Backs your “what the calories came from” framing. Why these foods genuinely relieve stress (your central, original thesis) Ulrich-Lai, Yvonne M., et al. “Pleasurable Behaviors Reduce Stress via Brain Reward Pathways.” Proceedings of the National Academy of Sciences, vol. 107, no. 47, 2010, pp. https://doi.org/10.1073/pnas.1007740107 Tomiyama, A. Janet, et al. “Comfort Food Is Comforting to Those Most Stressed: Evidence of the Chronic Stress Response Network in High Stress Women.” Psychoneuroendocrinology, vol. 36, no. 10, 2011, pp. 1513–1519. https://doi.org/10.1016/j.psyneuen.2011.04.005 — This is the science behind “the food was doing something right.” Palatable food measurably dampens the HPA (cortisol) stress axis through reward pathways — which is exactly why pulling it without replacing the stress tool fails. Why cravings are state-dependent and rise with stress (the “urge depends on the state of your blood / stress level” claim) Adam, Tanja C., and Elissa S. Epel. “Stress, Eating and the Reward System.” Physiology & Behavior, vol. 91, no. 4, 2007, pp. 449–458. https://doi.org/10.1016/j.physbeh.2007.04.011 Darcey, Valerie L., et al. “Brain Dopamine Responses to Ultra-Processed Milkshakes Are Highly Variable and Not Significantly Related to Adiposity in Humans.” Cell Metabolism, vol. 37, no. 3, 2025, pp. 616–628. https://doi.org/10.1016/j.cmet.2025.02.002  (edited)      WHAT TO EAT FOR THE NEXT SIX WEEKS — Protein. Plant. Potato. (P³) The formula for every meal: one protein + one plant + one starch (potato, or beans and rice). Add fat — olive oil, butter, avocado, cheese, nuts. Add flavor — salt, pepper, garlic, lemon, vinegar, salsa, hot sauce, herbs. This is not the meal you dreamed of. This is the meal that sets you free. BREAKFAST Eggs + sautéed vegetables + fruit on the side Plain Greek yogurt + berries + a handful of nuts Leftover chicken or beef + potato + vegetables (last night's dinner works) LUNCH Chicken + roasted potato + green salad with olive oil and lemon Tuna + white beans + cucumber + tomato, dressed with olive oil and vinegar Beef + potato + peppers + salsa DINNER Sheet-pan chicken + potatoes + green beans Instant Pot chicken + potato + a vegetable Burger patty (no bun) + potato + salad Batch chili (beef + beans + tomato) over rice Baked fish + sweet potato + roasted broccoli Pork + beans and rice + sautéed greens THE DURESS PLATE — for when the day collapses One protein + one plant + one starch, zero cooking. Examples: • Hard-boiled eggs + apple + handful of nuts • Tuna + canned beans + cucumber, with olive oil • Pre-cooked/frozen ground beef + frozen vegetables + microwave potato • String cheese + fruit + a few nuts (in a real pinch) SIMPLE RECIPES Sheet-Pan Chicken & Potatoes (serves 4) Toss chicken thighs and quartered baby potatoes in olive oil, salt, pepper, garlic. Roast at 425°F (220°C) ~35–40 min. Add green beans for the last 15 min. Batch Chili (serves 6) Brown 2 lb ground beef with chopped onion. Add 2 cans diced tomatoes, 2 cans beans (drained), garlic, cumin, chili powder, salt. Simmer 30+ min. Freezes well — make once, eat all week. Serve over rice. Instant Pot Chicken Chicken breasts + ½ cup broth + salt, garlic, paprika. Pressure cook 10 min, natural release 5. Shred. Pairs with any potato + vegetable. The 5-Minute Tuna Bean Bowl Can of tuna + can of white beans (rinsed) + diced cucumber and tomato. Dress with olive oil, lemon or vinegar, salt, pepper. Microwave Potato, Done Right Pierce a potato, microwave 5–7 min. Split, add butter or olive oil, salt, pepper. The reliable, universal starch. Remember: Don't aim for one perfect week repeated six times. Just follow the basic protocol the best you can for six weeks. When a craving hits, run the nine-minute interrupt from Episode 14.   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.

Intro; Holidays, Birthdays, Feedbag, Chub Hugs, Nostalgia, What’s In Your Lunchbox?, Hey Chubs, Advice; TV and Movie Reviews, and lots of chub talk! chubsgonewild@gmail.com Subscribe in iTunes! Right Click Here To Download ChubsGW644: Chub The Night Away

"It is no secret that music contracts can be rather brutal on artists. Often the stories focus on not getting paid but there is also the interesting idea of a lawsuit ordering a musician to fill his or her contract and record what we are calling a court ordered album. We have multiple examples plus one where the band was paid NOT to record an album."

"The New York Times released their 30 Greatest Living American Songwriters list a short while ago. I know online lists usually have some click bait to start conversation but this list was overtly egregious. Not for who was on it. It was who was left off. We will go over the list and play some artists that should have been on there."

"Sony Music Publishing confirmed an agreement to acquire Blackstone's Recognition Music Group catalog for $3.5 billion. The Red Hot Chili Peppers just sold their catalog for $300 million. Other Funds are raising billions to start buying. These buyers are called Music Rights Funds. I became interested in how these Funds actually made money. How does one invest and can I sell my own music. I have the answers for you."

Send us Fan MailIn this episode of Learning to Glow, I sit down with Yondje Choi, founder of OMA, to talk about the power of seaweed, warm foods, Korean wellness traditions, and simple daily rituals that support digestion, skin, energy, and overall health.She shares the beautiful story behind OMA and how her mom inspired the company after showing up at the hospital with homemade Korean seaweed soup, just one day after giving birth. That moment of nourishment became the heart of the brand.What we talked about:• Why seaweed is considered a superfood for thyroid health, hormones, metabolism, digestion, skin, and hair• The iodine gap and why many modern salts do not contain iodine• The benefits of warm foods, warm water, broth, and soup for digestion and energy• Skincare wisdom from her grandma• The power of small habits, simple routines, and consistency over perfectionGet 15% off Oma Natural Foods with Code JESS15 Click HERE for websiteFind Jess below!Website: Simply Jess Skincare SIMPLY JESS SKINCARE:Each and every product is naturally derived, highly concentrated and most importantly, super performing! Every product was born out of a need to have a truly pure product that met my high standards for efficacy. Subscribe to Our Newsletter! You can take 20% off Your Order of our all natural skincare line with code: PODCAST Shop Now! Favorite Supplements for Health and Fat loss: Click HERE  My favorites are the Power Greens, Digestive Enzymes and Brain Power Favorite Mouth and Face Tape- Use Code JESSICAITURZAETA15 for 15% off Click Here Mushroom Coffee-15% off with Code: SIMPLYJESSSKINCARE15 Click HereEmail Us! jess@learningtoglow.comFollow us! Instagram Tik Tok

12pm hour of The K&C Masterpiece! NFL Overreaction or Reality. Texas Rangers manager Skip Schumaker. My Buddy's an Idiot (American tennis players / Fat soldiers apparently / North Carolina track officials / Perhaps Jusuf Nurkic).

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is transforming personalized peptide protocols in functional medicine Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy Resources: • Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro & Guest Welcome 01:55 – Censorship & Platform Bans 06:20 – Peptide Science & Bioavailability 07:20 – Delivery Methods 14:30 – Supply Chain & US Manufacturing 17:01 – Manufacturing Risks & Contamination 24:43 – Peptide Stacks 28:41 – Immune Peptides & Thymus 30:57 – Overhyped Peptides 41:00 – Alternative Delivery (Patches, Nasal, Rectal) 47:25 – Side Effects & Risk 50:30 – Mixing & Storage Tips 54:05 – Wrap-Up & Where to Buy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Summer travel, holidays, BBQs, cruises, family gatherings, and social events can feel like a minefield when you're working to reverse insulin resistance. Episode #260

Most women who struggle with binge eating never talk about it. I'm changing that today. In this episode, I get personal about my own journey with binge eating, tracing it back to my early twenties and walking through the slow, nonlinear process of working through it over the past decade. This is not a quick fix episode. There is no finish line moment, no single breakthrough that made it all click. What there is, is an honest look at what actually moved the needle over time. I break down the three things that made the biggest difference in my healing: releasing the good food and bad food rules that were quietly running the show, going through a functional reverse diet to address what was happening on a physiological level, and reframing the stories I was telling myself after a binge episode. I also dig into something that does not get talked about enough, which is how your body's overall toxic load and sensitivity to certain foods can actually reinforce disordered eating patterns without you even realizing it. If you have ever felt completely out of control around food, finished a vacation feeling more guilt than joy, or wondered if you will ever stop the restrict and binge cycle, this episode is for you. You are not broken, and you are not alone.   Time Stamps:   (2:52) Visiting Mama Pozos At Hilton Head  (7:27) Defining Binge Eating  (12:22) Biggest Difference Makers With Controlling Binging  (14:14) Letting Go Of Food Rules  (16:50) Functional Reverse Dieting --------------------- Find Out More Information on Vital Spark Coaching --------------------- Follow @vanessagfitness on Instagram for daily fitness tips & motivation.  --------------------- Download Our FREE Metabolism-Boosting Workout Program --------------------- Join the Women's Metabolism Secrets Facebook Community for 25+ videos teaching you how to start losing fat without hating your life! --------------------- Click here to send me a message on Facebook and we'll see how I can help or what best free resources I can share! --------------------- Interested in 1-on-1 Coaching with my team of Metabolism & Hormone Experts? Apply Here! --------------------- Check out our Youtube Channel! --------------------- Enjoyed the podcast? Let us know what you think and leave a 5⭐️ rating and review on iTunes!

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Personal Experience00:47 – Root Cause: Not in Your Head01:05 – Blood Flow and Brain Function02:10 – The Calf Pump03:52 – Foot Sensory Signals04:26 – Nervous System Impact06:22 – How to Fix It07:51 – Personal ResultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. Sources: https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump https://www.bbc.com/news/articles/cedpz1zqp8po https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes. Sources: https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34 Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant. Sources: https://www.sciencedaily.com/releases/2026/05/260524012959.htm https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx https://www.eurekalert.org/news-releases/982100 https://www.eurekalert.org/news-releases/1116021 IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters. Sources: https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html https://www.eurekalert.org/news-releases/1128678 https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html https://clinicaltrials.gov/ New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study. Sources: https://www.science.org/doi/10.1126/science.adz1187 https://pubmed.ncbi.nlm.nih.gov/41610249/ https://www.nature.com/articles/d41586-026-00300-w https://www.eurekalert.org/news-releases/1113892 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6 Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:38 – Story 1: Enhanced Games 01:49 – Story 2: Kyle Busch Death (Sepsis) 03:09 – Story 3: Menin Protein and Brain Aging 04:37 – Story 4: Inflammation and Depression 06:20 – Story 5: Lifespan Heritability 07:47 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people stay stuck for years on something that could be done in weeks. This week the crew breaks down the story of one man who rebuilt what a whole city left broken for 140 years, and finished it in 52 days. The difference was ownership and urgency, not money or talent. JOIN US LIVE ON PATREON New audio every Tuesday, video every Wednesday, plus live recordings with the S2S fam. This is where the real conversations keep going. https://www.patreon.com/c/S2SPodcast120 PRE-ORDER "WE IS GREATER THAN ME" The debut book from Eric Thomas and CJ Quinney. https://www.amazon.com/We-Greater-Than-Me-Highest-ebook/dp/B0GPGXXD5D ENJOYING THE SHOW? If this episode hit you, take ten seconds to rate and review us on Apple Podcasts. It helps more people find us. Apple Podcasts: https://podcasts.apple.com/us/podcast/secret-to-success/id123456789 Spotify: https://open.spotify.com/show/0GrMsi1Cxj3nipnI9HR1QX?si=f057018bcba44c15 CHAPTERS Chapters 00:00:00 Opening: 140 Years vs 52 Days - The Wall That Changed Everything 00:02:33 Welcome and Team Introductions: Fresh Off the Plane Energy 00:05:01 Next Level Speakers Conference Announcement: Your 52-Day Moment 00:11:33 Fair or Foul: The Elderly Server Dilemma 00:14:54 The Tipping Epidemic: From Drive-Throughs to 35 Percent Suggestions 00:09:14 The Knicks Talk and Sports Banter: When Franchises Finally Break Through 00:20:49 The Sermon Breakdown: Self-Accountability and the 52-Day Principle 00:26:21 The Math That Will Blow Your Mind: 983 Opportunities Wasted 00:28:41 ET's Bathroom Story: When Vision Meets Self-Accountability 00:28:25 The Broken Comb Philosophy: Why DeDeThrows Things Away Immediately 00:38:03 Vision, Urgency, and Miracle Territory: The Three Keys to 52 Days 00:40:27 The Michael Jackson Warning: If You Don't Move, God Gives It to Prince 00:44:19 Rachel's Transformation: From Basement to 1.3 Million in Softball 00:45:47 The Hot Seat Moment: How 5,000 Dollars Changed Rachel's Life Forever 00:48:03 Rachel Creates the Next Mastermind: When Students Become Teachers 00:46:39 The Tithing Conversation: When Your Wife Gives 40 Percent 01:06:14 Toby and Fat's 8,000 Square Foot Mansion: Real Estate Without the Degree 01:06:14 Exposure Changes Everything: Why Most People Stay Broke 01:04:41 The Callus Principle: Why the First Brick Hurts the Most 01:10:15 Final Challenge: 140 Years or 52 Days - You Choose KALM DOWN WITH KARL Karl on why the callus comes before the breakthrough. The first brick hurts, but there is a point where you stop feeling it and start building faster than everyone still waiting to begin. MAL'S MILLIONAIRE MOMENT FEATURING JEMAL KING Jemal on why most people are not broke because they are lazy. They are broke because they have not been exposed to more. Your level of exposure determines your level of success. NEXT LEVEL SPEAKERS CONFERENCE June 5 to 7, 2026, Atlanta, GA. Learn to start, grow, and monetize your speaking brand. nextlevelspeakersconference.com APOC VIRTUAL CHURCH Saturdays 11am EST on YouTube. www.apocministry.org FOLLOW Instagram: @s2spodcast Subscribe on YouTube: https://www.youtube.com/@S2SPodcastChannel?sub_confirmation=1 ABOUT THE PODCAST The Secret to Success podcast is hosted by Eric Thomas, the Hip Hop Preacher, Karl Phillips, the Bajan Sensation, CJ Quinney, and Jemal King. Four friends, four journeys, one mission, real conversations on faith, family, business, and the work it takes to build a life that lasts. New episodes every Thursday.

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fat of The Land, Episode 4, Contorni“Mother Earth is really asking us to touch the soil… it's not just enough to pray. We need to put our hands in the soil.”  —Carlo MontesantiContorni. The side dishes, or the surroundings. In this fourth episode of our series Fat of The Land, we turn towards the question of taste: how it is cultivated and remembered. Through conversations with Carlo Montesanti and Arianna Gelpke, the episode traces the shifting contours of Italian food culture amid tourism, commercialisation, supermarket convenience, and the global appetite for an imagined “Italian cuisine.” What happens to taste when food becomes spectacle, an export or a brand? And, what tastes are lost? Can they ever be reclaimed?Moving across Sicily and Tuscany, this episode reflects on taste as not just as a matter of preference but as a way of reading the earth. Contorni provokes us to consider taste in all of its forms: sensorial, cultural, economic and ecological. What desires for taste reveal about hunger itself: hunger for nourishment, nostalgia, identity, and connection to a place past… or of the now. Fat of The Land is a series that asks us what we mean when we look for connection between people and the land. Following a desire for real relation, for deliciousness, and for slowness, each episode traces what happens when we follow this desire. This episode is brought to you by generous sponsorships from Ritū and Terra Elaÿa. Music and sound design in this episode is brought to you from the For The Wild Studio.Thank you to Jessie of Slow Life Family Farm and Arianna of Fattoria Corzano e Paterno for joining us in conversation.Biographies Carlo Montesanti, born in Siracusa, is an esteemed English-speaking guide in Eastern Sicily, known for his work with BBC nature documentaries and Netflix's Chef's Table series.Arianna Gelpke is a representative of her family's farm, Fattoria Corzano e Paterno. She is passionate for nature and working with the land in the pursuit of sustainable agriculture and high-quality artisan produce. Since Wendelin Gelpke purchased Corzano in 1971 and the subsequent addition of Paterno in 1974, the two-hundred-hectare farm has developed along three different lines: slow wine, olive oil, and artisanal cheese production, along with “Agriturismo.”Partners RitūFat of The Land is a series about what it means to be in relationship with land, food, and the people who tend both across generations. Ritū was made with the same kind of care; six ancient plants, ground and blended into a morning cup that honors the land it comes from, delivered in a compostable bag that returns to the earth.Ritu built a custom landing page for us and would like to offer For The Wild listeners 25% their first month with a discount code FORTHEWILD25. To order yourself some Ritu, head to drinkritu.com/forthewild.Terra ElaÿaThanks also to Elaÿa for the support of this series. Terra Elaÿa is a sanctuary where ancient ways meet the needs of our time. We emerge at this time of crossroads, standing as a space for the transformation, renewal, and re-enchantment of the human spirit. Located in the heart of southern Italy, we provide a place to come into a deeper relationship with life: to slow down, listen, and restore embodied wisdom.Head to terraelaya.com to learn more about upcoming Elaÿa experiences or to host an event. Support the show