Podcasts about ghr

Thanks for listening! Peeti V opens the show, followed by Crank. Hour 2 kicks off with Ron Reeser, and we close it out with Twenty Six making his GHR debut. Enjoy the show and let us know what you think. Drop a comment. IG: @ghettohouseradio X: @ghettohouse 

Thanks for listening! Magic Matt opens the show, followed by the legendary DJ/producer Richard Vission. Hour 2 kicks off with DJ Delight making his GHR debut, and we close it out with Riddler. Enjoy the show and let us know what you think. Drop a comment. IG: @ghettohouseradio X: @ghettohouse 

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

Bhí lá mór ag Cumann Gailf CCF ar an Fhál Carrach ar an tSatharn nuair a rinneadh an chéad fhód ar chlubtheach úr an chumann a thiontú. Bhí Conor Ó Gallachóir i láthair ag an ócáid maidin Dé Sathairn & labhair le Bean Chaptaen an Chumainn, Nóirín Uí Ghrádaigh, An Teachta Dála, Pat the Cope Ó Gallachóir & Joseph Mangan, Captaen Chumann Gailf CCF.

Afila rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Brim, Kim and Mr. Greer are back at it again. Apart from all the usual shenanigans, the gang chats about everything in pop culture with all the trimmings as they discuss who actually owns the Hollywood sign, the history of the sign itself - IE Hollywoodland, and who purchased a letter in honor of Groucho Marx. The crew also chats about the German kids who made a very interesting discovery, they question a medical examiner's credentials, discuss the home in Pennsylvania that had over 100 dead bodies in it, and the ongoing story thereof. The cast talks about Renee Good who was murdered by an ICE agent, how a GoFundMe account for her has reached upwards of 1.5 million thus far, and they offer a PSA about being kind to one another. They talk about the upside-down snow cone costumes worn on a cruise ship, Brim's appearance this weekend at the Nightmare Expo in Schenectady and GHR's addition onto the list of the 90 World's Best Pop Culture podcasts. The crew also discusses what the bigger flex would be concerning Hollywood ownage (a star or a letter), and a fun (yet gross) buffet story. The crew chats about entertainment news, opinions and other cool stuff and things. Enjoy.Wherever you listen to podcasts & www.thegrindhouseradio.comhttps://linktr.ee/thegrindhouseradio

GHR's Top Tracks of 2025 mixed by Audio 1 and Peeti V. Enjoy the show and let us know what you think. Leave a comment. Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382 Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio         Mix 1 Disco Lines Tinashe - No Broke Boys Mau P - The Less I Know The Better Chris Lake and Amber Mark - In My Head  Maesic, Marshall Jefferson, Salomé Das- Life Is Simple (Move Your Body) Chris Lake, Skrillex & ANITA B QUEEN - La Noche Layton Giordani & Green Velvet - When It Kicks Tiesto, Odd Mob & Good Boys - Won't Be Possible  Odd Mob, OMNOM & HYPERBEAM - System Dom Dolla ft. Daya - Dreamin  Mix 2 1.James Hype ft. Sam Harper and Bobby Harvey - Waterfalls 2. OMNOM & Marco Strous – Everyone's Your Friend 3. Odd Mob, OMNOM & Hyperbeam – Coming Up (It's Dare) 4. Sammy Virji & Chris Lake ft. RoRo – 925 5. Disclosure & Anderson .Paak – NO CAP 6. Max Styler – I Know You Want To 7. Chris Lake & Ragie Ban – Toxic 8. Mau P – TESLA 9. James Hype – Don't Wake Me Up (VIP Mix) Mix 3 1. Lady Gaga – Abracadabra (Kue's Studio 54 Disco Remix) 2. Hatiras – Hypnotized 3. TOKiMONSTA ft. Oby Onyioha – Enjoy Your Life 4. Goshfather – Where Were U 5. MK ft. Chrystal – Dior 6. MORTEN & ARTBAT – Culture 7. Richard Vission & Bad Boy Bill – Higher Planet 8. Don Diablo – Freek Like Me 9. Pawelo – Holding Back The Years 10. Bad Bunny – DtMF (Kue Studio 54 Mix) 11. Tiesto – RVN (Raven) Mix 4 Proppa, Rich DietZ, Smith & Sorren - Work  Cloonee, Young M.A, InntRaw - Stephanie  Fallon - Diet Coke IHAVEN. ft. Kaitlin Aragon - I Run (DJ Prophet edit) InntRaw - Breathe  CYRIL & Kelland ft. Nate Dogg - I Got Love  CID x Taylr Renee - Fancy $hit Kaskade - DNCR John Summit feat. Inez - Light Years   

Cyril rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Mau P rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Diplo rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Marshall Jefferson rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Faighimid léargas cuimsitheach ó Ghráinne Ní Aodha faoin toghchán uachtaránachta, cá seasann na páirtithe pholaitíochta ar fad, cé hiad an eite chlé agus an eite dheis, agus cad atá romhainn mar thír.

Martin Ikin rocks this edition of our GHR exclusive podcast mix series. Thank you for listening. Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382 Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Fáilte ar ais chuig eagrán nua de Ar An Lá Seo ar an 3ú lá de mí Dheireadh Fómhair, liomsa Lauren Ní Loingsigh. I 1980 bhí plean nua ann chun an dífhostaíocht a laghdú do na daoine óga I mBaile Átha Cliath. Tháinig an nuacht amach ó aire don lucht oibre. I 1986 bhí bean agus fear ag tiomáint I gcarr difriúil agus bhuail siad díreach in éadan an chairr eile taobh amuigh de Eochaill agus mharaíodh an bheirt acu. I 2002 tháinig an nuacht amach go raibh Nicky English chun seas siar óna ról mar bhainisteoir den fhoireann iománaíochta Tiobraid Árann. Tháinig sé amach go ndúirt sé leis na n-oifigí go raibh sé ag iarradh seas siar óna bpost agus bhí an fhoireann ag féachaint do bhainisteoir nua. I 2010 chaill Drom-Inch I gcoinne Sarsfield Durlas san iománaíocht. Bhuaigh Sarsfield don 41ú h-uair I dTeampall Mór. Dúradh go raibh an cluiche teann agus go raibh a lán teannas ann go dtí an deireadh. Sin The Police le Don't Stand So Close To Me – an t-amhrán is mó ar an lá seo I 1980. Ag lean ar aghaidh le nuacht cheoil ar an lá seo I 2002 fuair Darryl DeLoach bás de bharr ailse ae ag aois 56. Bhí sé páirteach den banna cheol Iron Butterfly nuair a thosaigh siad. I 2011 tháinig sé amach go raibh Queen le We Are The Champions an t-amhrán is somheabhraithe a scríobh aon duine riamh. Agus ar deireadh breithlá daoine cáiliúla ar an lá seo rugadh drumadóir Tommy Lee sa Ghréig I 1962 agus rugadh amhránaí Gwen Stefani I Meiriceá ar an lá seo I 1969 agus seo chuid de amhrán. Beidh mé ar ais libh an tseachtain seo chugainn le heagrán nua de Ar An Lá Seo. Welcome back to another edition of Ar An Lá Seo on the 3rd of October, with me Lauren Ní Loingsigh 1980 New plans to ease youth unemployment in one of the the state's job blackspots, the inner city of Dublin, were announced by the minister for labour. 1986: a man and woman driving in seperate cars were both killed in a head on collision outside Youghal. 2002 - TIPPERARY Senior Hurling Boss Nicky English decided to call it a day after a four-year term at the helm. The Lattin-Cullen man informed officers of the County Board that he wished to step down from his position as Manager of the Premier County, and the hunt was on for a successor to be named.  2010 - Thurles Sarsfields dethroned the Mid Tipperary senior hurling title holders Drom-Inch to claim their 41st ever divisional title in Templemore. A game that was played in a tight and tense atmosphere went right down to the wire. Sars won 1-16 to Drom's 2-11.  That was The Police Don't Stand So Close To Me – the biggest song on this day in 1980 Onto music news on this day In 2002 Original guitarist, vocalist from American psychedelic rock band Iron Butterfly Darryl DeLoach died of liver cancer at the age of 56. 2011 According to new scientific research, Queen's 'We Are The Champions' was found to be the catchiest song ever written. And finally celebrity birthdays on this day – drummer Tommy Lee was born in Greece in 1962 and singer Gwen Stefani was born in America on this day in 1969. I'll be back with you next week with another edition of Ar An Lá Seo.

Fáilte ar ais chuig eagrán nua de Ar An Lá Seo ar an 10ú lá de mí Dheireadh Fómhair, liomsa Lauren Ní Loingsigh. I 1980 tháinig sé amach I rith 12 mhí chuaigh 60 míle duine ón tír chuigh Meiriceá de réir an ambasáid Meiriceánach. I 2003 tháinig sé amach go raibh na leantóirí Éireannach don rugbaí ag iarradh taisteal chuig an Astráil don Corn Domhanda ach bhí roinnt acu fágtha gan ticéad tar éis iad a ceannach ó chomhlach Briotanach agus bhí na Gardaí ag fiosrú é de bharr caimiléireacht. I 2007 bhí slatiascaire agus daoine a raibh ina chónaí san áit ar buile mar go raibh substaint bhán san Abhainn san Aonach Urmhumhan. Dúirt an Slatiascaire Ormond go raibh a lán truailliú ag dul ar aghaidh. Bhí an abhainn san Aonach Urmhumhan dath bán agus bhí eagla ar dhaoine gur mharaíodh a lán iasc. I 2008 bhí cúpla teach tábhairne ón chontae ag glacadh páirt sa tráth na gceist náisiúnta. Eagraithe ón VFI agus Stiléir Éireannach, bhí sé seo ar siúil gach bliain chun airgead a bhailiú do Ghrúpa Athshlánú. Sin Madonna le True Blue – an t-amhrán is mó ar an lá seo I 1986. Ag lean ar aghaidh le nuacht cheoil ar an lá seo I 2000 chan Britney Spears don chéad uair sa Bhreatain nuair a chan sí do trí oíche I Wembley Arena. I 2009 fuair Stephen Gately ó Boyzone bás go tobann ag aois 33 nuair a bhí sé ar a laethanta saoire I Majorca. Agus ar deireadh breithlá daoine cáiliúla ar an lá seo rugadh aisteoir Martin Kemp sa Bhreatain I 1961 agus rugadh amhránaí agus aisteoir Jodie Benson I Meiriceá ar an lá seo I 1961 agus seo chuid de amhrán. Beidh mé ar ais libh an tseachtain seo chugainn le heagrán nua de Ar An Lá Seo. Welcome back to another edition of Ar An Lá Seo on the 10th of October, with me Lauren Ní Loingsigh 1980: During the last 12 months alone, more than 60,000 Irish people visited the UNited States, according to the US Embassy in Dublin. 2003: irish rugby fans that were hoping to travel to next montsh world cup in Australia have been left without tickets after sending money to a british company which is being investigated for fraud. 2007 - Local anglers and members of the public were infuriated following a spill of a white substance into the Nenagh River. The Nenagh Ormond Anglers said a large volume of the polluting material emerged from the Clareen Stream. The Nenagh River turned a whitish colour for a long stretch, prompting fears of a major fish kill in the renowned brown trout, and Outrage as the Nenagh River turned white.  2008 - Several Tipperary pubs are taking part in the National Rehab/Powers Whiskey Pub Quiz. Organised in association with the Vintners Federation of Ireland (VFI) and Irish Distillers, the annual national pub quiz raises funds for the Rehab Group. The winning team from each pub will progress to the Tipperary county final.  That was Madonna with True Blue – the biggest song on this day in 1986 Onto music news on this day In 2000 Britney Spears made her UK live debut when she played the first of three sold out nights at London's Wembley Arena. 2009 Boyzone singer Stephen Gately died suddenly at the age of 33 while on holiday in Majorca. And finally celebrity birthdays on this day – actor Martin Kemp was born in the UK in 1961 and actress and singer Jodie Benson was born in America on this day in 1961 and this is one of her songs. I'll be back with you next week with another edition of Ar An Lá Seo.

Brim and Mr. Greer are back at it again. Apart from all the usual shenanigans, the gang chats about everything pop culture with all the trimmings including how GHR and Brimstone are up for the Best of LI Awards again, how to vote for them, and how it would be great to take the wins home to Grindhouse yet again. The crew also chats about how awesome the Rise of the Jack-o-Lanterns on Long Island is, Universal Studios moves towards a Disney style Fast Pass for popular rides, and Disney takes down the Hollywood Studios arch. The cast talks about Snapple, their history on Long Island, and that they are currently bringing back the glass bottles for a limited run in New York only. They talk about Colman Domingo being cast as the Cowardly Lion in Wicked: For Good, and the passing of Ace Frehley (KISS) and Sam Rivers (Limp Bizkit). The crew also discusses the Twitch streamer who was sexually assaulted at Twich Con, Historic jewels stolen in France, and Jim Carrey joining the cast of the Jetsons. The cast discusses Brim Wins including the Brimstone Dr. Dancaked pancake, Burnt Offerings now available on-tap at Necromantic Brew Co, and his recent appearance at Darkside Arts & Oddities Expo. The crew chats about entertainment news, opinions and other cool stuff and things. Enjoy.Wherever you listen to podcasts & www.thegrindhouseradio.comhttps://linktr.ee/thegrindhouseradioThe Grindhouse RadioFB: @thegrindhouseradioTW: @therealghradioInstagram: @thegrindhouseradio

James Hype rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Brim, Kim and Mr. Greer are back at it again. Apart from all the usual shenanigans, the gang chats about everything pop culture with all the trimmings. This week they're joined by Ralph of Necromantic Brew Co. to try Brim's 'Burnt Offerings' and other gluten free flavors. The crew also chats about Bad Bunny doing this year's half-time show, how he purposely set up a residency in Puerto Rico, and how he has helped raise a lot of money for the betterment of PR. The cast talks about Dutch Wonderland in Pennsylvania, Amish talk, and Conor MacGregor asking for 100mil to fight on the White House lawn. The crew also discusses Brim's new menu item at Island Lake Diner on Long Island, they question if we actually went to the moon or not, and gossip about the splitting of Nicole Kidman and Kieth Urban. The cast discusses the Emmys (again), flat earthing, and possible problems with Ryan Reynolds and Blake Lively. The crew chats about entertainment news, opinions and other cool stuff and things. Enjoy.Wherever you listen to podcasts & www.thegrindhouseradio.comhttps://linktr.ee/thegrindhouseradioThe Grindhouse RadioFB: @thegrindhouseradioTW: @therealghradioInstagram: @thegrindhouseradio

Hatiras rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Thanks for listening. JEANINE DA FEEN opens the show followed by DJ/Producer RICHARD VISSION. Kicking off hour 2 making his GHR debut MAESIC. Closing the show PEETI V. Enjoy the show and let us know what you think. Leave a comment. *All Music Provided by all Major Labels *No Copyright Issues Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382 Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Agatha Hurst, ó Ghrúpa Faire Míolta Móra agus Deilfeanna na hÉireann ag labhairt faoin bhfeachtas bailithe airgid atá acu le leantóir a cheannach.

An raibh "Silly Season" againn i mbliana? Cé atá ag rith don Áras? An deachtóir é Trump? Ar cheart do ghealltanas pósta Taylor Swift agus Travis Kelce a bheith ina cheannlíne nuachta? Cuirimid na ceisteanna seo ar fad ar Ghráinne Ní Aodha.

Hugel rocks this edition of our GHR exclusive podcast mix series. Taking us all over the world. This is a world mix. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Audio1 rocks this edition of our GHR exclusive podcast mix series. It's all about Drum & Bass. Thank you for listening. 01. Bladerunner - Come Again 02. Sub Killaz, Profile & Sub Zero - Let's Go 03. Sub Focus, Culture Shock & Fragma - Miracle 04. Wilkinson - Come Down 05. 1991 & Rova - Hijack 06. Ekko & Sidetrack - Up Late 07. Kanine - Feel The Vibration 08. FreebaseFM - Away 09. Pirapus - BODY DROP (Won't Stop) 10. Kanine - Bloodstream 11. Mozey - Nerdy Roller 12. Grafix & Rova - Let Me Down 13. 1991, Mugatu & Mali-Koa - Love In The Answer 14. HUGEL & Diplo ft. Malou & Yuna - Forever (Jauz Remix) 15. Redlight - 9ts Baby (Disrupta Bootleg) 16. Serum & The Riddler - Ain't No Way (Bladerunner Remix) 17. Morgan Seatree, Florence + The Machine - Say My Name (Sub Focus Remix) 18. Lady Gaga & Bruno Mars - Die With A Smile (FREEMXN Remix) 19. Ookay - Walk Away 20. Arcando - California Dreamin' 21. Rova - Left 2 Right 22. Rudimental ft. Jess Glynne - Back To Me *All Music Provided by all Major Labels *No Copyright Issues Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382 Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio        

Brim, Kim and Mr. Greer are back at it again. Apart from all the usual shenanigans, the gang chats about everything pop culture with all the trimmings and discusses Shark Week, Tom's dislike of Shark Week programming, and Brim's enjoyment of it. They also chat about playing Celebrity Softball, and how the GHR crew did a good job playing. The cast talks about the new Superman movie, the resurgence of crazy popcorn buckets and they discuss what's right and wrong for comedians. The crew also discusses the passing of legendary personalities, Malcolm Jamal Warner, Ozzy Osbourne and the free offerings of tapioca for watching Matlock (as per Greer). The cast chats about Stephen Colbert losing his job and the end of Late Night, Shane Gillis and the Espy's, as well as a mention of Caitlyn Clark. They discuss Chicago's Epic Con controversy, and the increasing surge of conventions around the country. The crew chats about entertainment news, opinions and other cool stuff and things. Enjoy.Wherever you listen to podcasts & www.thegrindhouseradio.comhttps://linktr.ee/thegrindhouseradioThe Grindhouse RadioFB: @thegrindhouseradioTW: @therealghradioInstagram: @thegrindhouseradio

Beo ón Aithin sa Ghréig, áit a bhfuil dáltaí ó Phobalscoil Ghaoth Dobhair ag glacadh páirte i gComórtas Eorpach Comhlacht na Bliana Junior Achievement 2025.

Becky Ní Éallaithe, ceoltóir & damhsóir, & Alanagh Ní Ghríofa Ní Chonghaile damhsóir & amhránaí ar Ardán an Cheoil & ag labhairt faoina dturas ar Cheanada le gairid.

Thanks for listening. RIDDLER opens the show followed by PEETI V. Kicking off hour 2 DJ/Producer MARC STOUT. Closing the show making his GHR debut GOSHFATHER. Enjoy the show and let us know what you think. Leave a comment. *All Music Provided by all Major Labels *No Copyright Issues Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382 Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Ag plé cuairt an Aire Tithíochta James Browne go Dún na nGall inné áit ar chas sé le toscaireacht ó Ghrúpa Gníomhaíochta na mBrící Lochtacha le linn a chuairte.

Thanks for listening. AUDIO 1 opens the show followed by DJ/Producer CYRIL. Kicking off houu 2 RIDDLER. Closing the show making his GHR debut PAWELO. Enjoy the show and let us know what you think. Leave a comment. *All Music Provided by all Major Labels *No Copyright Issues Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382 Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

The Global Heat Reduction Initiative's Kiff Gallagher talks with Ian Welsh about 'Total Climate Accounting', a framework created by GHR to address critical gaps in current climate metrics by incorporating super pollutants like methane and black carbon. They discuss how this approach provides organisations with actionable data to reduce near-term warming while maintaining long-term decarbonisation goals – revealing why traditional carbon accounting falls short in today's crisis.

Brim, Kim and Mr. Greer are back at it again. Apart from all the usual shenanigans, the gang chats about everything pop culture with all the trimmings including why Disney very well may be concerned about the new Universal Studios theme park. The cast talks about how fans can play against Brim and Mr. Greer on the Portal One App, the success of Syndicate Smokedown in Texas, bad GHR cast habits, and Kim's brief obsession with Euro Truck Simulator. The crew also discusses the film 'The Life List' on Netflix, the McDonald's Minecraft meal mix-up, and how the trailer for Brim's season od 'And Just Like That'. The cast chats about how Katoe Perry and a few others went into space for about ten minutes via Jeff Bezos, Kim gives an airport update, the meaning of yellow capped Coca-Cola, and how it would be amusing if flat earthers were right. They discuss the Jason Momoa as Lobo, as well as Yo-Gabba-Gabba at Coachella. The crew chats about entertainment news, opinions and other cool stuff and things. Enjoy.Wherever you listen to podcasts & www.thegrindhouseradio.comhttps://linktr.ee/thegrindhouseradioThe Grindhouse RadioFB: @thegrindhouseradioTW: @therealghradioInstagram: @thegrindhouseradio

Dúirt Seanán Mac Aoidh, Bainisteoir Phobal Eascarrach ar an Fhálcarrach agus ball den Ghrúpa Tinteán, go bhfuil sé tábhachtach castáil le Comhairle Condae Dhún na nGall leis na deacrachtaí atá ag cainteoirí Gaeilge tithe a aimsiú ina mbaile féin a phlé.

GHR's Road to Coachella Mix 2025 mixed by AUDIO 1. 01. Mau P - The Less I Know The Better 02. David Penn, Vintage Culture  & Raphaella - Just Stay The Night 03. Lola Young - Messy - BVRNOUT Remix 04. Chris Lorenzo & High Jinx - California Dreaming' 05. Alok & Firebeatz - Higher State Of Consciousness 06. Chris Lake & Aluna - Beggin' 07. Cloonee, Young M.A. & InntRaw - Stephanie (Disco Dom Refunk) 08. Lady Gaga - Abracadabra (Kue's Studio 54 Disco Remix) 09. Basement Jaxx - Red Alert 10. Tiesto & Oscar L - Flex 11. Zedd - Shave It 12. Above & Beyond - We're All We Need 13. Charli XCX ft. Billie Eilish - Guess 14. Sean Paul and Odd Mob - Get Busy 15. Shermanology - Beat Of The Drum 16. Skrillex, Missy Elliott & Mr. Oizo - Ratata 17. Kaskade & Punctual ft. Poppy Baskcomb - Heaven Knows 18. salute & Disclosure - lift off! 19. Chase & Status ft. Stormzy - Backbone 20. The Prodigy - Breathe (Mefjus & Camo & Krooked Remix) 21. Chase & Status and Bou - Baddadan 22. Chase & Status and Bou - Baddadan (TANTRON Remix)     *All Music Provided by all Major Labels *No Copyright Issues   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse  

Here is a new mix that was aired recently with the fam on @ghettohouseradio featuring a collective of house, EDM, & some pop/dance/mainstream remixes/bootlegs. I hope you enjoy the mix

Here is a new mix that was aired recently with the fam on @ghettohouseradio featuring a collective of house, EDM, & some pop/dance/mainstream remixes/bootlegs. I hope you enjoy the mix

Here is a new mix that was aired recently with the fam on @ghettohouseradio featuring a collective of house, EDM, & some pop/dance/mainstream remixes/bootlegs. I hope you enjoy the mix

Amhrán ó Rang a 3 atá acu ón Dráma ‘An Ghréasaí agus na Leipreacháin' a dheineadar le déanaí ar stáitse i gcomórtas ‘Coirm' le Gael-Linn.

Day 65 of preparing body and mind to run 3,000 kilometers around the coast of Ireland—equivalent to 71 marathons back-to-back.Today's dispatch captures Damian Browne at 4:40 AM, bleary-eyed in his car, wrestling with doubt and fatigue before heading to the gym. What unfolds is a raw, unfiltered look at the grind of endurance training: a morning of running intervals, a body teetering on the edge of injury, and a mind battling to stay disciplined.This episode marks week one of a new training cycle, with Damian pushing 40% more running volume than the previous week while carefully managing Achilles discomfort. The shift to early morning sessions is paying off—better recovery, sharper focus—but the real story lies in the mental game. Resistance, Damian reflects, isn't a barrier; it's a signal of fertile ground for building resilience. Tune in for an honest account of progress, setbacks, and the quiet victories that keep this monumental challenge alive.In This Episode:✔️ Early mornings, new habits: Why training at dawn is reshaping recovery and discipline✔️ Running intervals breakdown: 31 minutes of treadmill work—5x2 min, 7x3 min—at a faster pace than last week✔️ Achilles tightrope: Navigating lingering discomfort and the fear of overdoing it✔️ Strength tweaks: Adding glute ham raises (GHR) and sit-ups to align hips and spine for better running form✔️ The mental edge: Turning resistance into fuel for growth amidst doubt and uncertaintyFor the Deep Roots AudienceThis episode is for the relentless—those who chase authenticity, test their limits, and find purpose in the struggle. Damian's journey speaks to adventurers, dreamers, and anyone striving to carve meaning from the chaos of daily life. His vulnerability and grit will ignite your own drive to keep pushing forward, no matter the odds.

Brim, Kim and Mr. Greer are back at it again. Apart from all the usual shenanigans, the gang chats about everything pop culture with all the trimmings and they discuss the Oscar's, how the Wicked performance was well - wicked, the twenty year payback kiss by Halle Berry, and the Kendrick Lamar joke laid out by Conan O'Brian. The cast talks about the recent deaths in Hollywood (Gene Hackman, Michelle Trachtenberg, Buster Poindexter), how Olivia Rodrigo and Sabrina Carpenter apparently made up, and Drake ends his lawsuit with iHeartRadio about the Kendrick Lamar diss track. The crew also chats about Kingda Ka being destroyed at Six Flags in Jersey, unsafe rides, and how GHR anticipates visiting Universal's Epic Universe before they open. The cast chats about the recent Marvel leaks, DVD's from Warner Bros and how Disney is steering away from long-form animation. They also discuss how John Cena going heel after all these years. The crew chats about entertainment news, opinions and other cool stuff and things. Enjoy.Wherever you listen to podcasts & www.thegrindhouseradio.comhttps://linktr.ee/thegrindhouseradioThe Grindhouse RadioFB: @thegrindhouseradioTW: @therealghradioInstagram: @thegrindhouseradio

Here is a new mix that was aired recently with the fam on @ghettohouseradio featuring a collective of house, EDM, & some pop/dance/mainstream remixes/bootlegs. I hope you enjoy the mix

Here is a new mix that was aired recently with the fam on @ghettohouseradio featuring a collective of house, EDM, & some pop/dance/mainstream remixes/bootlegs. I hope you enjoy the mix

Beidh cruinniú poiblí ag an Ghrúpa Sábháil Ionad Oideachais Dhún na nGall i mBaile Dhún na nGall tráthnóna inniu leis an Ionad Oideachais ar an bhaile atá le haistriú go Leitir Ceanainn a phlé.

Here is a new mix that was aired recently with the fam on @ghettohouseradio featuring a collective of house, EDM, & some pop/dance/mainstream remixes/bootlegs. I hope you enjoy the mix

Here is a new mix that was recently aired with the fam on @ghettohouseradio, featuring a collection of the top house tracks from 2024. I hope you enjoy the mix

Here is a new mix that was recently aired with the fam on @ghettohouseradio, featuring a collection of the top house tracks from 2024. I hope you enjoy the mix

GHR's Top Tracks of 2024 Mix 1 Danny Avila, Sam Wolfe, HNTR, Rome Fortune - Yes B!tch  Fisher, Flowdan - Boost Up Marlon Hoffstadt - It's That Time (Fisher remix) Will Clarke, BURNS - Give Me Laidback Luke, Ronald Clark - Praise To The Bass John Summit, Hayla - Shiver Nimino - I Only Smoke When I Drink Zerb, The Chainsmokers, Ink - Addicted  Hugel, Diplo ft. Malou & Yuna - Forever Diplo, Riva Starr, Kareen Lomax - Heaven or Not   Mix 2 Chris Lake, Sammy Virji ft. Nathan Nicholson - Summertime Blues Mau P - Beats For The Underground John  Summit - Eat The Bass Sebastian Ingrosso & Steve Angello - Skip Steve Angello - Me Cyril - Stumblin' in (Arno Cost & Norman Doray Remix)  C.I.D. vs Spankox - To The Club DJ Snake, Peso Pluma - Teka HI-LO, Green Velvet, Dajae - Lift me up Dom Dolla - girl$ Mix 3 Skrillex, Hamdi, TAICHU, OFFAIAH, Contra - Push Pickle - Get Silly John Summit, Sub Focus ft. Julia Church - Go Back Ella Henderson ft. Rudimental - Alibi Fredagain… Anderson. Pack, CHIKA - Places to be Chase and Status, Stormzy - Back Bone Fred Again… Baby Keem - leavemealone Kabin Crew & Lisdoonvarna Crew - The Spark Mix 4 Mau P - Merther Alesso - Zig Zag Swedish House Mafia, Niki and The Dove - Lioness Mr. Belt and Wezol - It's Not Right But It's Ok Richard Vission - Bom Bom Bom Meduza, Hayla - Another World Swedish House Mafia, Alicia Keys - Finally James Hype ft. Shamiya Battles - 7 Seconds Adam Port, Stryv, Keinemusik, Orso, Malachiii- Move *All Music Provided by all Major Labels *No Copyright Issues Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382 Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio  

Here is a new mix that was aired recently with the fam on @ghettohouseradio featuring a collective of house, EDM, & some pop/dance/mainstream remixes/bootlegs. I hope you enjoy the mix

Micheál Ó Cinnéide - Feirmeoir ó Bhaile na bPoc atá i gcoinne an tairiscint ó Ghrúpa Chiarraí, go ndíolfaí an gnó déiríochta Kerry Dairy Ireland do Chomharchumann Chiarraí. Pádraig Ó Scanláin - Feirmeoir ó Dhún Chaoin atá den tuairim gur bhfuil Grúpa Chiarraí mar chomlacht comhábhar bia nach bhfuil bainne de dhíth orthu a thuilleadh

Audio1 rocks this edition of our GHR exclusive podcast mix series. Jungle and Drum Bass mix. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio