Podcasts about ghr

Mindset Change Community LinkAnxiety is Your Wake-Up Call Book.If anxiety, stress and overthinking are taking up too much space in your life, this Anxiety & Stress Freedom Hypnosis is designed to help you feel calmer, more present and more in control of how you respond.This thirty-minute hypnosis session combines deep relaxation with powerful hypnotic suggestions to help you change your relationship with anxious thoughts, stress and familiar patterns of overthinking.Find somewhere comfortable where you won't be disturbed, close your eyes and allow yourself to fully experience the session.For the greatest benefit, listen regularly and allow the experience to deepen with repetition.Please do not listen while driving or operating machinery. This hypnosis is for relaxation and personal development and is not a substitute for medical or psychological treatment.About Paul Sheppard Start Your Mindset Upgrade NowMy work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok

This week on GHR, we're bringing you another nonstop mix of house, techno, and everything dance music. Birthday boy Peeti V kicks things off, Crank takes over next, Riddler keeps the energy moving, and Australian DJ/producer Cyril closes out the show. Turn it up and let's get into it! IG: @ghettohouseradio X: @ghettohouse

Unlock Your Success Mindset Community LinkWhat if the opportunities for more success, wealth and abundance are already around you — but your mind simply isn't noticing them?In this episode, I'm sharing a surprisingly simple mindset exercise designed to change what you focus on, what you notice and potentially what becomes possible for you.All you need is a coin.And I'll also share something rather strange that happened to me this week while I was thinking about this exact exercise. Coincidence, neuroscience or something a little more mysterious? You can decide.Try this with me for seven days and see what happens.You might be surprised by what starts showing up.About Paul Sheppard Start Your Mindset Upgrade NowMy work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok

If your mind is constantly pushing and pulling you with overthinking, anxiety, stress, self-doubt and endless stories about what you want, or don't want, this meditation is an opportunity to step out of the struggle.Mental Freedom Meditation will guide you away from getting caught in the mind's repeating patterns and back into a natural state of calm, presence and awareness. This is a powerful place to create your happiness and success in life from.Using the breath, periods of silence and open awareness, you'll practise noticing thoughts and impulses without automatically following them — creating more space between you and the narratives of your mind.You don't need to stop thinking.You can simply learn to stop being pulled around by every thought.Take this time to slow down, become present and experience the freedom that becomes available when the mind no longer has to run the show.About Paul Sheppard Start Your Mindset Upgrade NowContact me Info@mindsetchangeuk.com - I will look forward to hearing from you.My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok

Send us Fan MailFor the past four decades, Chris Farrell has been on radio stations across the country. He was part of the launch team of Heart 106.2 in London, where he hosted shows for nearly 17 years. He has also enjoyed stints on stations that included MFM, TFM and Horizon Radio.This week Chris sits down with Luke to share stories of his radio journey. Some of the stories include joining Essex Radio when he was just 10 years old, and working on stations around the country, to landing full time work on MFM, before moving down to Horizon and the Hot FM. Joining a new service in London called Heart 106.2 and what the launch date was like. Moving to America and coming back to the UK to take on work with Radio Jackie and GHR 80's.Check out some of these airchecks of Chris courtesy of Aircheck DownloadsAlso why not give Chris a follow on Instagram @chrisfarrellradio

Start your mindset upgrade now, community link.Read my book Anxiety doesn't have to take over your life.In this episode, I share 3 simple steps to help you move from anxious to more calm, confident and in control, without fighting how you feel.Accept. Breathe. Choose.You'll learn how to stop making anxiety mean something is wrong, calm your nervous system through your breath, and change the way you label what you're experiencing. It really is simple and very effective.Anxiety is normal. It will pass. And you can learn to respond differently when it shows up.About Paul Sheppard Start Your Mindset Upgrade NowMy work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok

This week on the GHR podcast, we're taking you straight to France as DJ and producer Kungs takes over the mix. Known for his funky, feel-good house sound, Kungs brings his signature energy and a selection of tracks that keep the vibes moving from start to finish. I've been a fan of Kungs for years, so I'm excited to have him featured on this edition of the GHR podcast. Press play and discover why his sound continues to stand out. Kungs in the mix on Ghetto House Radio. IG: @ghettohouseradio X: @ghettohouse 

New Mindset Community HereAnxiety is Your Wake-Up Call Book.I love a simple meditation where you are guided to relax your mind and body for a calm and healing experience. Just 12 minutes to take you to a deeply relaxing state of being so you can rest.Enjoy.About Paul Sheppard Start Your Mindset Upgrade NowMy work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok

One of your favourite meditations returns to help you learn to rest, relax and recover. Let me guide you into a deep muscle relaxation with gentle breath work exercises and inner work to transform your mind.About Paul Sheppard Begin your Mindset Upgrade Now.My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok

Free Kindle Book Version LinkMindset Change Community Skool Link.Finally my book Anxiety is Your Wake-Up Call is now out on Amazon and to celebrate its release the kindle version of the book is free for today the 9th and tomorrow the 10th.I would love to know your thoughts about the book and please do leave an Amazon review, it would be deeply appreciated. I have also created a brand new Skool community where you can come for live coaching, have your questions answered, receive support, take courses and have access to exclusive access to content for members only.In this episode I read the introduction of my new book and explain why current approaches with anxiety can often let people down as they can over focus on the mind and not the bigger picture.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community

This week on Ghetto House Radio, Riddler kicks things off with fresh dance music before Crank takes over with a high-energy mix packed with bangers!  Hour 2 brings something special as Kaleena Zanders makes her GHR debut, bringing her signature sound and powerful energy to the mix. Then Ecto1 takes us home and closes out the show with more nonstop dance-floor vibes. House, dance, big energy and new music. This is GHR! Listen this week and let's dance! IG: @ghettohouseradio X: @ghettohouse 

Explore, expand and raise your level of consciousness with this guided Non Sleep Deep Rest Meditation. This is one of my favourite practises to help you relax on a deeper level than before to explore what and who you are beyond the noise of your thinking mind.Let me know how this was for you.New content coming next week.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

GHR introduces you to a new DJ/producer duo from San Francisco: Dual State! JLittle and Clayton William, aka Dual State, bring a special live back-to-back set recorded on a rooftop in San Francisco with the city as the backdrop. Expect deep grooves, house vibes, and nonstop energy as these two go head-to-head in the mix.   This is one of those sets that makes you wish you were on that rooftop!   Press play, turn it up, and experience the vibe. And if you want to see the live set, check out Clayton William and JLittlemusic on Instagram.   Like, follow, subscribe, and leave a comment. Let us know what you think!   IG: @ghettohouseradio   X: @ghettohouse  

A powerful way to start your day is to enter a theta brainwave state to reprogram your mind for manifesting. This guided meditation will work with your RAS in your brain to help filter reality to look for the opportunities to help you grow and expand your success. Make this a daily practise to rewire your brain for the success and happiness you dream of."I wonder what miraculous opportunities you will notice coming your way today?"Let me know what happens for you in the comments.New meditations and hypnosis sessions coming soon.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

Belgian DJ and producer Yves V takes over this edition of the GHR Exclusive Podcast Mix! Known for his high-energy sound and massive dancefloor records, Yves V delivers a nonstop mix packed with feel-good vibes, big drops, and straight-up bangers. This is a special GHR exclusive mix, bringing you more than what you hear on the regular radio show. Turn it up wherever you're listening and enjoy the ride! Like what you hear? Make sure to like, follow, subscribe, and leave a review. It helps us spread the word about GHR and continue supporting dance music culture around the world. Thanks for listening and supporting GHR! IG: @ghettohouseradio X: @ghettohouse

GHR is coming in HOT this week! Peeti V kicks things off, then German superstar Robin Schulz takes over the mix with those signature dance vibes. Hour 2 gets CRAZY with Crank bringing nothing but bangers and serious energy, then Riddler closes it out. Turn it UP!    IG: @ghettohouseradio X: @ghettohouse

This guided meditation will take you deep into the quantum field to help you focus on manifesting like never before. The feedback from this meditation when it was originally released has been phenomenal which is why I wanted to share it again here.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community

Join me for a guided meditation which teaches you how to slow down and quieten an overthinking and busy mind. Find the peace, clarity and focus you are looking for.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

This week on GHR, Jeanine Da Feen kicks things off with a high-energy mix, followed by Marc Stout keeping the dance floor moving. Hour two brings Brazilian twin brothers and DJ/producer duo Dubdogz with their signature sound, and Riddler closes out the show with more dance music to keep you going. Two hours, four DJs, nonstop dance music on GHR.   IG: @ghettohouseradio  X: @ghettohouse 

Give yourself the gift of a mindset reset. These are some of my favourite meditations which work deeply inside your mind to help create lasting change from within.Enjoy.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

One of the most listened to episodes ever on the show. Hypnosis is very effective for pain release and management. Let me guide you into a deep trance to help you heal.There are some new hypnosis episodes coming soon, let me know what you need help with.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

This week on Ghetto House Radio, Peeti V kicks off the show with a high-energy mix packed with the latest dance music. Then we welcome the multi-talented Raphi, a DJ, producer, and singer who's all about house music and bringing her own sound and energy to the dance floor. Hour two turns up the heat with Crank delivering nonstop bangers before we close things out with Shimza, bringing his signature Afro Tech vibes all the way from South Africa to take us home. Turn it up and enjoy another week of GHR!   IG: @ghettohouseradio X: @ghettohouse

Nuacht Mhall. Príomhscéalta na seachtaine, léite go mall.*Inniu an cúigiú lá déag de mhí Lúnasa. Is mise Oisín Mac Conamhna.Chuir an t-athrú aeráide agus téamh domhanda isteach go mór ar an Eoraip an tseachtain seo, le breis agus céad go leith milliún duine faoi theocht de 35 céim nó níos mó Dé hAoine, agus falscaithe ar fud na hilchríche. Is iomaí teach a cailleadh i ndóiteán sa Lár-Réigiún Thiar i Sasana, agus cuireadh naoi ndauine déag chun ospidéil ann. Cailleadh duine i bhfalscaí sa Chróit, agus d'aistrigh níos mó ná míle duine amach as an gceantar údaí. Bhí falscaithe móra eile sa Ghréig, sa Ghearmáin, sa Fhrainc, agus sa Spáinn. Tógadh amach taisce na mainistreacha San Juan de la Pena in Aragón i dtuaisceart na Spáinne, ar fhaitíos go gcaillfí é i bhfalscaí atá ag díriú ar na mainistreacha; agus bhí ar an Rómáin a n-imoibreoir núicléach a mhúchadh, toisc easpa uisce in abhainn na Danóibe.Bhí lá iontach ag Éirinn ag Craobhchomórtais na hEorpa in Birmingham Déardaoin. Bhain Mark English, ó Leitir Ceanainn, Dún na nGall, bonn óir sa rás ceannais ocht gcéad méadar, in éis dó ceithre bhonn cré-umha agus bonn airgid a bhaint ag comórtais eile. Is eisean an chéad fhear a bhain bonn óir d'Éirinn riamh i gCraobhchomórtais na hEorpa, agus é sé bliana níos sine ná éinne eile sa rás ceannais. Fiche nóiméad níos déanaí, bhain Rhasidat Adeleke, ó Thamhlacht, Baile Átha Cliath, an bonn airgid dhá chéad méadar, ar an líne, le curiarracht náisiúnta nua de 22.28 soicind.Bhí urú na gréine le feiceáil ar fud iarthar na hEorpa Dé Céadaoin. Páirturú a bhí ann den chuid is mó, acht i gconair chúng a thosaigh i dtuaisceart na Sibéire, agus a chuaigh trí oirthear na Graonlainne, iarthar na hÍoslainne, tuaisceart na Spáinne, agus na hOileáin Bhailéaracha, bhí lánurú ann. Tá lánuraithe na gréine thar a bheith speisialta agus annamh, agus is le linn lánurú amháin atá sé sábháilte chun breathnú ar an ngrian le súile nochta. Is ar éigean a sheachain conair an lándorchadais cósta thiar na hÉireann, ina raibh páirturú domhain, agus scamaill ar fud na tíre faraor; acht in Zaragoza i dtuaisceart na Spáinne, a bhí faoi spéir ghlan i gconair an lándorchadais, bhí radharc aoibhinn álainn le feiceáil thart ar a leathuair in éis a hocht sa tráthnóna, nuair a chuaigh an ghealach trasna aghaidh na gréine go hiomlán, go híseal thar fhíor na spéire san iarthuaisceart. Ag tús an lánuraithe, bhí léiriú láidir den fheiniméan ar a dtugtar an “fáinne diamaint”, nuair a thaibhsíonn atmaisféar na gréine timpeall na gealaí, le ponc amháin d'aghaidh na gréine fós ag lasadh trí ghleann ar imeall na gealaí ar nós seoide. In éis an fháinne diamaint, bhí starraiceachta brúchtacha gréine gléigeala bándearga le feiceáil go soiléir le súile nochta timpeall an diosca dubh na gealaí, suite i lonradh airgid ainglí na corónach, an t- atmaisféar taobh amuigh den ghrian, uilig leabaithe i spéir neamhshaolta dhorcha. Bhí daoine ag gáir agus ag gol le hionadh agus le háthas, agus in éis [canúint; in áit “tar éis”] ceithre scór is ceathair soicind d'iontas agus de dhraíocht, bhí an lánurú thart. Beidh lánurú na gréine eile le feiceáil ar an dara lá de mhí Lúnasa an bhliain seo chugainn, i ndeisceart na Spáinne, i dtuaisceart agus Adharc na hAfraice, agus i Leithinis na hAraibe.*Léirithe ag conradh na Gaeilge i Londain. Tá an script ar fáil i d'aip phodchraolta.*GLUAISilchríoch - continentimoibreoir núicléach - nuclear reactorin éis - after (canúint Mhaigh Eo)súile nochta - naked eyesconair - pathstarraiceachta brúchtacha gréine - solar flares

Create abundance in your life with this powerful meditation. Let me guide you into a deeply relaxing meditation where you can access success mode and become the abundant state you seek. Remember, we don't attract what we want, we attract what we are.Thank you for meditating with me as it changes the world more than you can know.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

A simple meditation for inner peace. I truly believe that we can create powerful lives from a peaceful and present state of mind. Let me guide you into experiencing a deep relaxing state of being to help you discover the truth of who you are.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

NSDR Meditation: Letting Go Without EffortA guided non-sleep deep rest (NSDR) meditation for deep relaxation, stress relief, and letting go — from Paul Sheppard on the Ultimate Mindset Change podcast.In this guided meditation, you'll do something a little different: instead of trying to relax, you'll discover the body already knows how to release what it's holding. You only need to observe.Beginning with the breath, this full body scan moves from the crown of your head down to your feet, letting tension soften without effort. Along the way, Paul invites you to notice the part of you that's straining to make something happen — and to let that part rest. When the controlling mind quietens, your true self has space to rise.You'll also sit with a question worth carrying into your day: what is here right now, when there are no problems to solve?This NSDR session is ideal for: afternoon rest and recovery, calming an overactive mind, releasing anxiety and tension, and anyone new to non-sleep deep rest.Pairs beautifully with the Letting Go and Be Free challenge, also on the Ultimate Mindset Change podcast.Find a comfortable position, soften your gaze, and let your eyes close like curtains at the end of the day.Please don't listen while driving or operating machinery.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community

Thanks for listening! This week's GHR features Peeti V kicking things off, followed by DJ Kue in the mix. In the second hour, DJ Delight keeps the energy going before we wrap things up with an exclusive back-to-back set from Arty and Laidback Luke. Enjoy the show!   IG: @ghettohouseradio X: @ghettohouse

No meditation experience needed. Lie back and listen, I will do the rest.A gentle 15-minute NSDR meditation (Non-Sleep Deep Rest) to heal and relax your whole mind and body — and open the door to a higher level of consciousness you can carry into the rest of your day.Paul Sheppard guides you through a golden healing light visualisation, beginning with a simple two-part breath: drawing warm light into the belly and chest, pausing, then exhaling slowly through the mouth to release anything heavy you've been carrying. In the stillness at the end of each breath, you'll meet your natural state — quiet, spacious and always available.From the crown of your head down to your toes, the golden light moves through the body, softening the scalp, smoothing the forehead, loosening the jaw, releasing the shoulders and settling the spine vertebra by vertebra, supporting your body's innate healing ability along the way.Midway through, you'll bring someone you love to mind — a person or a pet — and rest in a loving-kindness affirmation: I am resting deeply within myself, feeling loved.The session closes with a simple but powerful inquiry — I wonder what my next thought will be — a practice that reveals the gap between you and your thinking, and reminds you that you are not your thoughts, not your mind, not your feelings. You are the awareness that observes them all.In this episode:The two-part golden light breath for deep relaxationExtended exhales to release tension and quiet the mindA full-body healing light scan, crown to feetGratitude and loving-kindness to shift your energyThe affirmation: I am resting deeply within myself, feeling lovedThe "next thought" inquiry for glimpsing pure awarenessHow to tap into stillness in small pauses throughout your dayWhether you lie down or sit upright, this is an ideal reset for stressful days, an afternoon energy dip, or winding down before sleep. Just 15 minutes to soften, let go, and come home to yourself.Please don't listen while driving or operating machinery.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

Tá bainisteoir Ghrúpscéim Uisce Loch Oirbhirte agus Leitir Mealláin i gConamara ag fáiltiú roimh mholadh na Gníomhaireachta Um Chaomhnú Comhshaoil go mbeadh dualgas ar chuile ghrúpscéim príobháideach uisce sa tír clárú leis na húdaráis áitiúla, ach cur ar a gcumas an costas breise a bhainfeadh leis sin a sheasamh.

No meditation skills required. Lie back, listen, and let go. In this guided NSDR meditation (Non-Sleep Deep Rest), Paul Sheppard walks you through one of the simplest and most powerful ways to meditate — no experience needed, no effort required.You'll begin with a peripheral vision technique that quietens the default mode network, the part of the brain responsible for self-talk, rumination and mental time-travel into the past and future. It's a tool you can use anywhere, in seconds, to drop instantly into the present moment.From there, Paul guides you through a heart-centred gratitude practice and a full-body relaxation scan — releasing tension from scalp to toes — before working with the breath and the natural pause at the end of each exhale to stimulate the vagus nerve, reduce inflammation and settle the nervous system into deep calm.The session closes with a gentle self-inquiry practice: looking inward for the part of you that's trying, and discovering what remains when that effort dissolves — pure awareness, the you beneath the noise of the mind.In this episode:The peripheral vision technique for instant presenceHow the default mode network drives ego, worry and overthinkingA gratitude practice to shift your energy in momentsFull-body progressive relaxation and tension releaseBreath pauses, the vagus nerve and the relaxation responseSelf-inquiry: dissolving the part of you that's tryingResting as awareness — your natural state of beingPerfect for anxiety and stress relief, an afternoon reset, winding down before sleep, or recovering from burnout. Find a comfortable place to lie down, press play, and simply let it happen.Please don't listen while driving or operating machinery.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

Andrew Dorle is the Director of Investment Operations and Analytics at GHR Foundation.  Based out of Minneapolis, GHR's mission is to is to be of service to people and their limitless potential for good.Andrew takes us through his migration from the investment side into operations — the unexpected lessons that carried over and why that dual perspective has become a competitive advantage. We dig into how GHR moved analytics from a secondary focus into the core of decision-making.From there we discuss how communication works between teams, why data integrity is the non-negotiable first principle, and what a lean, all-director team can do faster when they're aligned on the fundamentals.We get tactical on technology and vendor strategy - their philosophy on best-in-breed versus all-in-one platforms, how they evaluate new entrants and where AI can realistically help a small, nimble foundation move the needle on workflows. For anyone building or scaling operations at a foundation or multi-family office — this is a conversation on what foundation operations can look like when operational discipline and analytical rigor are aligned.Learn More Follow Capital Allocators at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@tseides⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Subscribe to the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠mailing list ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Access transcript with ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Premium Membership ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Editing and post-production work for this episode was provided by The Podcast Consultant (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://thepodcastconsultant.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠)

Nalika Gajaweera (Research Affiliate, Walter H. Capps Center, University of California, Santa Barbara; PhD, Anthropology, University of California, Irvine, 2013) is an anthropologist of Buddhism, race, and ethics, with a focus on community well-being and resilience. Her current book manuscript, Transforming the American Sangha, funded by the Kataly Foundation, is an ethnography of the Insight Meditation movement in North America, focused on the efforts of practitioners of color to raise awareness of oppressive racial conditions in these communities. Her doctoral research examined how Buddhist ethics and practices of giving shaped Sri Lankan local NGOs doing humanitarianism work in the context of two disasters: the Indian Ocean tsunami of 2004 and ethnic conflict that ended in 2009. A former Fulbright fellow, Dr. Gajaweera has conducted fieldwork in North America and South Asia, managing and conducting complex multi-stakeholder research projects, exploring power building efforts among marginalized groups. Funders for these projects included Kataly Foundation, John Templeton Foundation, Hilton Foundation and GHR. Nalika Gajawira will collaborate with Ann Gleig on a comparative ethnographic study of how Buddhist communities adopt and adapt popular spiritual exercises such as "secular" mindfulness and yoga classes within a wider Buddhist framework. Their work aims to illustrate the processes, frameworks and relationships that can enable more responsible relationships between specific religious communities and the word of spiritual wellness practices. Visit Sacred Writes: https://www.sacred-writes.org/templeton-working-group Visit Nalika Gajaweera: https://nalikagajaweera.com/ https://dornsife.usc.edu/crcc/profile/nalika-gajaweera/  

This week's GHR lineup: Peeti V gets things started, Riddler keeps the energy going, Magic Matt takes over to kick off the second hour, and Yves V closes out the show. IG: @ghettohouseradio X: @ghettohouse 

GHR: 700 Pounds of Fireworks Go Boom (7-2-26)Brim and Mr. Greer are back at it again. Apart from all the usual shenanigans, the gang chats about everything in pop culture with all the trimmings. They discuss the multiple Chase employees making news for getting fired within weeks, Terrifier getting sued by Ruthless Studios, and Waymo gets kicked out of NYC. The crew also chats about Harry Styles collapsing on stage, the house in Seattle that blew up from 700 pounds of fireworks being set on fire, and a very interesting conversation about Joe Dirt. The cast talks about the woman who stole $32k in Lottery tickets, and Bricks and Minifigs coming to a truce with Reckless Ben. They talk about gaming, Funcoland and Gamestop, and the new GTA 6. The crew chats about entertainment news, opinions and other cool stuff and things. Enjoy.Wherever you listen to podcasts & www.thegrindhouseradio.comhttps://linktr.ee/thegrindhouseradio

Nothing but heat this week on GHR! Kicking things off is Ron Reeser, followed by Riddler, then Afila. Closing out the show is one of the hottest DJ/producers in dance music right now, HUGEL, celebrating the release of his brand-new album, Twenty One. Turn it up! IG: @ghettohouseradio X: @ghettohouse 

Pride Month is here and GHR is bringing the soundtrack. Loud, proud, and made for the dance floor. Here's the GHR Pride Mix, mixed by Jeanine Da Feen. ❤️

Thanks for listening. DJ Ecto 1 kicks off the show in the mix, followed by the legendary Richard Vission. Up next, R3wire makes his GHR debut. Wrapping up the show, Magic Matt. IG: @ghettohouseradio  X: @ghettohouse

Over 2 decades deep in the dance music game and we're celebrating a massive milestone. Kicking off show 1000 with an all-star lineup featuring Kaskade, Laidback Luke, Mau P, and Steve Aoki in the mix.   From the early days to now... thank you for riding with us through every era of dance music. This is GHR show 1000.   IG: @ghettohouseradio X: @ghettohouse

Thanks for listening! One of the dopest house music labels, Aliens on Mushrooms, takes over GHR. We kick things off with the label boss Gettoblaster, followed by Franklyn Watts. Hour 2 jumps off with Harvé, and we wrap it up with the legendary DJ Sneak, rocking an all-vinyl set.  IG: @ghettohouseradio X: @ghettohouse

Thanks for listening! Kue kicks off the show, followed by Riddler. Hour 2 starts with Miss Mia making her GHR debut, and we close things out with DJ/producer duo KREAM. Enjoy the show and let us know what you think. Drop a comment!  IG: @ghettohouseradio  X: @ghettohouse

Thanks for listening! Peeti V opens the show, followed by Crank. Hour 2 kicks off with Ron Reeser, and we close it out with Twenty Six making his GHR debut. Enjoy the show and let us know what you think. Drop a comment. IG: @ghettohouseradio X: @ghettohouse 

Thanks for listening! Magic Matt opens the show, followed by the legendary DJ/producer Richard Vission. Hour 2 kicks off with DJ Delight making his GHR debut, and we close it out with Riddler. Enjoy the show and let us know what you think. Drop a comment. IG: @ghettohouseradio X: @ghettohouse 

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

Afila rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Brim, Kim and Mr. Greer are back at it again. Apart from all the usual shenanigans, the gang chats about everything in pop culture with all the trimmings as they discuss who actually owns the Hollywood sign, the history of the sign itself - IE Hollywoodland, and who purchased a letter in honor of Groucho Marx. The crew also chats about the German kids who made a very interesting discovery, they question a medical examiner's credentials, discuss the home in Pennsylvania that had over 100 dead bodies in it, and the ongoing story thereof. The cast talks about Renee Good who was murdered by an ICE agent, how a GoFundMe account for her has reached upwards of 1.5 million thus far, and they offer a PSA about being kind to one another. They talk about the upside-down snow cone costumes worn on a cruise ship, Brim's appearance this weekend at the Nightmare Expo in Schenectady and GHR's addition onto the list of the 90 World's Best Pop Culture podcasts. The crew also discusses what the bigger flex would be concerning Hollywood ownage (a star or a letter), and a fun (yet gross) buffet story. The crew chats about entertainment news, opinions and other cool stuff and things. Enjoy.Wherever you listen to podcasts & www.thegrindhouseradio.comhttps://linktr.ee/thegrindhouseradio

GHR's Top Tracks of 2025 mixed by Audio 1 and Peeti V. Enjoy the show and let us know what you think. Leave a comment. Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382 Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio         Mix 1 Disco Lines Tinashe - No Broke Boys Mau P - The Less I Know The Better Chris Lake and Amber Mark - In My Head  Maesic, Marshall Jefferson, Salomé Das- Life Is Simple (Move Your Body) Chris Lake, Skrillex & ANITA B QUEEN - La Noche Layton Giordani & Green Velvet - When It Kicks Tiesto, Odd Mob & Good Boys - Won't Be Possible  Odd Mob, OMNOM & HYPERBEAM - System Dom Dolla ft. Daya - Dreamin  Mix 2 1.James Hype ft. Sam Harper and Bobby Harvey - Waterfalls 2. OMNOM & Marco Strous – Everyone's Your Friend 3. Odd Mob, OMNOM & Hyperbeam – Coming Up (It's Dare) 4. Sammy Virji & Chris Lake ft. RoRo – 925 5. Disclosure & Anderson .Paak – NO CAP 6. Max Styler – I Know You Want To 7. Chris Lake & Ragie Ban – Toxic 8. Mau P – TESLA 9. James Hype – Don't Wake Me Up (VIP Mix) Mix 3 1. Lady Gaga – Abracadabra (Kue's Studio 54 Disco Remix) 2. Hatiras – Hypnotized 3. TOKiMONSTA ft. Oby Onyioha – Enjoy Your Life 4. Goshfather – Where Were U 5. MK ft. Chrystal – Dior 6. MORTEN & ARTBAT – Culture 7. Richard Vission & Bad Boy Bill – Higher Planet 8. Don Diablo – Freek Like Me 9. Pawelo – Holding Back The Years 10. Bad Bunny – DtMF (Kue Studio 54 Mix) 11. Tiesto – RVN (Raven) Mix 4 Proppa, Rich DietZ, Smith & Sorren - Work  Cloonee, Young M.A, InntRaw - Stephanie  Fallon - Diet Coke IHAVEN. ft. Kaitlin Aragon - I Run (DJ Prophet edit) InntRaw - Breathe  CYRIL & Kelland ft. Nate Dogg - I Got Love  CID x Taylr Renee - Fancy $hit Kaskade - DNCR John Summit feat. Inez - Light Years   

Cyril rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Mau P rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Diplo rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio

Marshall Jefferson rocks this edition of our GHR exclusive podcast mix series. Thank you for listening.   Subscribe to the GHR Podcast: itunes.apple.com/us/podcast/ghett…adio/id435480382   Website: www.weareghr.com Facebook: www.facebook.com/ghettohouseradio Twitter: www.twitter.com/ghettohouse Instagram: www.instagram.com/ghettohouseradio