Laboratory technique to multiply a DNA sample for study
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In this episode of Speaking of Mol Bio, host Steve Lewis speaks with Dr. Melissa Wu, co-founder and CEO of Seeding Labs, a nonprofit that's redefining global scientific access. Dr. Wu shares the inspiring story of how Seeding Labs helps institutions in developing nations build research infrastructure by redistributing surplus laboratory equipment from partners like Thermo Fisher Scientific.With an innovative model that connects equipment donors in the global North with universities and institutes across Africa, Asia, and Latin America, Seeding Labs enables groundbreaking science in places where opportunity is limited but talent is abundant. Dr. Wu highlights examples like the Malawi University of Science and Technology, whose graduates are now staffing the country's first hospital microbiology labs, and a Beninese research team using donated PCR equipment to improve the yield of indigenous crops like the miracle berry.More than a logistics operation, Seeding Labs is also fostering scientific networks, reversing brain drain, and giving researchers confidence, courage, and agency. Dr. Wu offers a compelling vision of an equitable global scientific ecosystem, and shares how listeners can get involved—whether by donating equipment, funds, or simply spreading the word. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague. Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.
Lending his 25-year-old OLD soul voice, Canadian Liev Dalton, creator and host of his podcast and collective Beyond Terrain, shares his truth awakening story from his time in college. He observed firsthand the flaws of academia and science, from germ theory to PCR tests, and used the lockdown period to study, reflect and think critically. In our episode, he discusses the nature of law, fires, glyphosate spraying, whole terrain, synthetics, toxins and talks of dentistry by highlighting the studies of Canadian dentist, Westin A. Price. PS - he now has a master's in counseling psychology and runs a wilderness therapy practice. Closing with the "Just Be Practice," he encourages us to look outward so we can turn inward.Show Reference:Westin A. Price: https://www.westonaprice.org/#gsc.tab=0Connect with Liev:Website: https://BeyondTerrain.com/beyond-terrain-academy IG: https://www.instagram.com/beyond.terrain/?hl=en*Host Eden Koz is a soul realignment specialist utilizing psychological empathy, intuition, psychic ability, mediumship, meditation, mindset shift, Reiki, dimensional and galactic healing, to name a few. She also performs spiritual Co#id Vac+ Healing as well as remote & face-to-face sessions with individuals and groups. Contact info for Eden Koz / Just Be®, LLC:Website: EdenJustBe.com Socials: Insta, FB, FB (Just Be), TikTok, LinkedInJust Be~Spiritual BOOM Podcast can be found on Video directories: BitChute, Rumble, YouTube, Odysee, Grassroots Warrior Network. Audio directories: Apple Podcasts, Spotify, ...
5246 風とあそぶ:) 20250902TUE 今日のCOVID-19・・・1752回目リスク回避・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
Edwin Gonzalez shares his journey from a BioBuilder apprentice to becoming a lead scientific support specialist at Thermo Fisher by age 23, highlighting how hands-on experiences and mentorship shaped his career path.• Middle school science teacher sparked Edwin's interest in science through engaging projects and supportive environment• First in his family to pursue science, without STEM role models at home• Joined BioBuilder apprenticeship program in 2019 after learning about it from a classmate• Gained first hands-on lab experience learning aseptic technique, pipetting, PCR, and bacterial transformation• Worked on biodesign project to create a device detecting airborne allergens• BioBuilder experience helped him decide to major in biology at Suffolk University• Skills learned at BioBuilder created foundation that made college coursework easier• Landed first industry position at Novo Nordisk through connections from a LabCentral internship• Currently works at Thermo Fisher as a lead scientific support specialist• Role combines lab operations, facilities management and direct research support• Recommends exploring multiple aspects of biology to build a diverse toolkit of experiencesLearn more about BioBuilder's programs for students, educators, and industry professionals here
5243 風とあそぶ:) 20250901MON 今日のCOVID-19・・・1751回目空気感染・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
5240 風とあそぶ:) 20250831SUN 今日のCOVID-19・・・1750回目人災・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
ResourcesClick here to learn about United Ostomy Associates of America (UOAA) National Quality Ostomy Care Campaign, including the Ostomy and Continent Diversion Patient Bill of Rights,.Click here to view a list of patient resources that the WOCN Society has curated, including services, products, and publications. You can also bookmark and/or share the following web address with your colleagues and patients: IDeserveaWOCNurse.com.Click here to view and use the Peristomal Skin Assessment Guide for Clinicians and Consumers,. You can also bookmark and/or share the following web address with your colleagues and patients: psag.wocn.org.Click here to learn more about Janet's session at WOCNext® 2025, “I Have an Ostomy, Where can I go?: Challenges of Setting Up An Ostomy Clinic,.”The WOCN Society, in collaboration with the American Society of Colon and Rectal Surgeons (ASCRS) and the American Urological Association (AUA), developed the educational resources to assist clinicians in selecting an effective stoma site. Click here to review these resources.If you're a healthcare professional looking to deepen your knowledge of ostomy care, explore the joint WOCN and ASCRS Ostomy Care Management (OCM) Program—an evidence-based, online education designed to enhance care delivery and improve outcomes for individuals living with an ostomy. Click here to learn more.Journal of Wound, Ostomy, and Continence Nursing (JWOCN®) articles referenced in this episode:Bridging the Gap: Perceived Educational Needs in the Inpatient to Home Care Setting for the Person With a New OstomyLessons Learned About Peristomal Skin Complications Secondary Analysis of the ADVOCATE TrialOstomy and Continent Diversion Patient Bill of Rights Research Validation of Standards of CareOther articles referenced in this episode: The ostomy leak impact tool: development and validation of a new patient-reported tool to measure the burden of leakage in ostomy device usersImpact of stoma leakage in everyday life: data from the Ostomy Life Study 2019Factors impairing quality of life for people with an ostomy About the SpeakerJanet has enjoyed 40 years in WOC Nursing. Although her early nursing career focus was critical care as a certified critical care registered nurse she certified as a CWOCN in 1985. In 1996, she embarked in a private WOC practice, first as a partnership and then as sole proprietor practicing across the continuum with a focus on ostomy care coupled with a passion for patients attaining their desirable quality of life. Janet worked in outpatient ostomy clinics serving different populations and challenges... adding a bit of spice to her practice and recently retired from patient care.Janet lectures nationally and internationally, has published on Quality of Life of People Living with an Ostomy and co-authored both a home study course on Wound Management & Healing and an educational video on Common Perineal Skin Injuries, and. She participates in Ostomy and Incontinence Associated Dermatitis research and actively participates with WOCN and industry to move ostomy care forward. Her peers awarded her the PCR* ET Nurse of the Year Award in 1996, PCR* President's Award in 2000 and PCR* Professional Educational Award in 2004.*PCR stands for the Pacific Coast Region of the WOCN Society, what is now known as the Pacific Coast Chapter of the WOCN Society (or PCC for short). The WOCN Society has 11 chapters throughout the country that support WOCN members at a local level with resources, education, networking opportunities, social gatherings, timely information, and more. For additional information, please visit wocn.org/Chapters. Editing and post-production work for this episode was provided by The Podcast Consultant.
5237 風とあそぶ:) 20250830SAT 今日のCOVID-19・・・1749回目根拠なき政治の介入・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
5234 風とあそぶ:) 20250829FRI 今日のCOVID-19・・・1748回目公衆衛生上の危機・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
Can you handle the heat? Aarati tells the story of the nature-loving scientist whose discovery of Thermus aquaticus, a microbe living in the hot waters of Yellowstone Park, helped make PCR one of the fundamental tools of biotech. Support the showFor more information and sources for this episode, visit https://www.smartteapodcast.com.
5231 風とあそぶ:) 20250828THU 今日のCOVID-19・・・1746回目脆弱な情報・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
5228 風とあそぶ:) 20250827WED 今日のCOVID-19・・・1746回目札幌市下水サーベイランス・・・■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
5225 風とあそぶ:) 20250826TUE 今日のCOVID-19・・・1745回目フィルター・・・■株式会社 CLEAIRhttps://cleair-w.com/■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
5222 風とあそぶ:) 20250825MON 今日のCOVID-19・・・1744回目費用の壁・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
YEP…Its another episode of You Asked, We Answered! In this episode, we will look at the data to answer 2 questions that came into the show within the last 24 hrs: 1. Is oral or topical therapy best for first treatment of uncomplicated vulvovaginal candidiasis? (We have new data- AJOG, Sept 2025, to answer that), and 2. Is urine PCR testing for UTI diagnosis a “routine practice”? (We will look at 4 sources of information to answer that one). Listen in for details. 1. Gardella, Barbara et al. Treatment of uncomplicated vulvovaginal candidiasis: topical or oral drugs? Single-day or multiple-day therapy? A network meta-analysis of randomized trials. American Journal of Obstetrics & Gynecology, Volume 233, Issue 3, 152 - 1612. Invited Commentary: JAMA Netw Open: Published Online: November 26, 20242024;7;(11):e2446711. doi:10.1001/jamanetworkopen.2024.467113. March 2025 (AAFP): Are the Advantages of Urine PCR Testing Worth the Higher Costs? https://www.aafp.org/pubs/afp/afp-community-blog/entry/are-the-advantages-of-urine-pcr-testing-worth-the-higher-costs.html4. July 2025: PALTmed: https://paltmed.org/news-media/paltmed-calls-providers-stop-using-routine-pcr-urine-tests-utis5. https://pathnostics.com/limitations-of-pcr-only/
5219 風とあそぶ:) 20250824SUN 今日のCOVID-19・・・1743回目注意喚起は大切です・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
Drs. Whitney Hartlage (@whithartlage11) and Sam Windham join Dr. Ryan Moenster to discuss updates in the diagnosis and management of community-acquire pneumonia. Hear from our guests on the role of rapid diagnostic tests such as multiplex PCR and urinary antigen tests in the inpatient and outpatient setting, considerations for initiating steroids and withholding macrolides, and when to use short antibiotic durations. Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/. Visit our website! https://breakpoints-sidp.org/ References: Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. PMID: 31573350; PMCID: PMC6812437. Chaudhuri D, Nei AM, Rochwerg B, Balk RA, Asehnoune K, Cadena R, Carcillo JA, Correa R, Drover K, Esper AM, Gershengorn HB, Hammond NE, Jayaprakash N, Menon K, Nazer L, Pitre T, Qasim ZA, Russell JA, Santos AP, Sarwal A, Spencer-Segal J, Tilouche N, Annane D, Pastores SM. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024 May 1;52(5):e219-e233. doi: 10.1097/CCM.0000000000006172. Epub 2024 Jan 19. PMID: 38240492. Odeyemi Y, Tekin A, Schanz C, Schreier D, Cole K, Gajic O, Barreto E. Comparative effectiveness of azithromycin versus doxycycline in hospitalized patients with community acquired pneumonia treated with beta-lactams: A multicenter matched cohort study. Clin Infect Dis. 2025 May 16:ciaf252. doi: 10.1093/cid/ciaf252. Epub ahead of print. PMID: 40378193. Butler AM, Nickel KB, Olsen MA, Sahrmann JM, Colvin R, Neuner E, O'Neil CA, Fraser VJ, Durkin MJ. Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults. Clin Infect Dis. 2024 Oct 23:ciae519. doi: 10.1093/cid/ciae519. Epub ahead of print. PMID: 39442057; PMCID: PMC12355227. Furukawa Y, Luo Y, Funada S, Onishi A, Ostinelli E, Hamza T, Furukawa TA, Kataoka Y. Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis. BMJ Open. 2023 Mar 22;13(3):e061023. doi: 10.1136/bmjopen-2022-061023. PMID: 36948555; PMCID: PMC10040075 Schober T, Wong K, DeLisle G, et al. Clinical outcomes of rapid respiratory virus testing in emergency departments. JAMA Intern Med. 2024;184(5):528-536. Clark T, Lindsley K, Wigmosta T, et al. Rapid multiplex PCR for respiratory viruses reduces time to result and improves clinical care: results of a systematic review and meta-analysis. J Infect. 2023;86(5):462-475. May L, Robbins EM, Canchola JA, Chugh K, Tran NK. A study to assess the impact of the cobas point-of-care RT-PCR assay (SARS-CoV-2 and Influenza A/B) on patient clinical management in the emergency department of the University of California at David Medical Center. J Clin Virol. 2023:168:105597. Cartuliares MB, Rosenvinge FS, Mogensen CB, Skovsted TA, Andersen SL, Østergaard C, et al. Evaluation of point-of-care multiplex polymerase chain reaction in guiding antibiotic treatment of patients acutely admitted with suspected community-acquired pneumonia in Denmark: a multicentre randomised controlled trial. PLoS Med. 2023;20:e1004314. doi: 10.1371/ journal.pmed.1004314. Vaughn VM, Dickson RP, Horowitz JK, Flanders SA. Community-acquired pneumonia: a review. JAMA. 2024;332(15):1282-1295. Davis MR, McCreary EK, Trzebucki AM. Things we do for no reason – ordering Streptococcus pneumoniae urinary antigen in patients with community-acquired pneumonia. Open Forum Infect Dis. 2024;11(3):ofae089. Centers for Disease Control and Prevention. Laboratory Testing for Legionella. Updated June 9, 2025. Accessed July 13, 2025. https://www.cdc.gov/legionella/php/laboratories/index.html. Jain S, Self WH, Wunderink RG. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med. 2015;373(5):415-427. Kamat IS, Ramachandram V, Eswaran H, Guffey D, Musher DM. Procalcitonin to distinguish viral from bacterial pneumonia: a systematic review and meta-analysis. Clin Infect Dis. 2020;70(3):538-542. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single blinded intervention trial. Lancet. 2004;363:600–7. doi: 10.1016/S0140- 6736(04)15591-8. Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, Widmer I, et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA. 2009;302:1059–66. Schuetz P, Muller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, et al. Procalci- € tonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Datab System Rev. 2017;10(10):CD007498. doi: 10.1002/14651858. cd007498.pub2. Huang DT, Yealy DM, Filbin MR, Brown AM, Chang C-CH, Doi Y, et al. Procalcitonin-guided use of antibiotics for lower Respiratory tract infection. New Engl J Med. 2018;379:236–49. doi: 10.1056/NEJMoa1802670. Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in severe community-acquired pneumonia. N Engl J Med. 2023;389(19):1623-1634. doi:10.1056/NEJMoa2215145. Gupta AB, Flanders SA, Petty LA, et al. Inappropriate diagnosis of pneumonia among hospitalized adults. JAMA Intern Med. 2024;184(5):548-556. Jones BE, Chapman AB, Ying J, et al. Diagnostic Discordance, Uncertainty, and Treatment Ambiguity in Community-Acquired Pneumonia: A National Cohort Study of 115 U.S. Veterans Affairs Hospitals. Ann Intern Med. 2024;177(9):1179-1189. doi:10.7326/M23-2505. Hartlage W, Imlay H, Spivak ES. The role of empiric atypical antibiotic coverage in non-severe community-acquired pneumonia. Antimicrob Steward Healthc Epidemiol. 2024;4(1):e214. doi:10.1017/ash.2024.453. Dinh A, Barbier F, Bedos JP, et al. Update of guidelines for management of community acquired pneumonia in adults by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF). Endorsed by the French Infectious Disease Society (SPILF) and the French-Speaking Society of Respiratory Diseases (SPLF); endorsed by the French Intensive Care Society (SRLF), the French Microbiology Society (SFM), the French Radiology Society (SFR), and the French Emergency Society (SFMU). Respir Med and Res. 2025. El Moussaoui R, de Borgie CAJM, van den Broek P, et al. Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study. BMJ. 2006;332(7554):1355. doi:10.1136/bmj.332.7554.1355. Dinh A, Ropers J, Duran C, et al. Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia: a randomized, non-inferiority trial. 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5216 風とあそぶ:) 20250823SAT 今日のCOVID-19・・・1742回目空気感染にはマスク・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
Dr. Sumanta (Monty) Pal and Dr. Arielle Elkrief discuss the clinical relevance of the gut microbiome in cancer immunotherapy and the importance of antibiotic stewardship, as well as interventions currently being explored to treat gut dysbiosis and optimize immunotherapy response. TRANSCRIPT Dr. Sumanta (Monty) Pal: Hi everyone, I'm Dr. Monty Pal, welcoming you to the ASCO Daily News Podcast. I'm a medical oncologist. I'm a professor and vice chair of academic affairs at the City of Hope Comprehensive Cancer Center in Los Angeles. Today we're here to discuss one of my favorite topics, which is the gut microbiome. It's almost hard to avoid the gut microbiome nowadays if you look at medical literature within oncology. It's an emerging phenomenon, but there are a couple of individuals that I would really define as pioneers in the field. And one of them is actually with me today, Dr. Arielle Elkrief, to discuss the clinical relevance of the gut microbiome, particularly amongst patients receiving immunotherapy, although I imagine our conversation today will take many twists and turns. Arielle is an assistant professor and clinician scientist in the Department of Oncology at the University of Montreal, and she is co-director of the CHUM Microbiome Center there. FYI for the listeners, we have our full disclosures in the transcript of this episode. Arielle, thank you so much for joining us today. Dr. Arielle Elkrief: Thanks so much, Monty. This is going to be amazing. Dr. Sumanta (Monty) Pal: Well, I have to tell you what sort of inspired me to bring you on as a guest. It was one of many things, but it was this really terrific ASCO Educational [Book] article that you wrote. Now, I have to tell you, I've read all the articles sort of cover to cover in the book, and they're always a wonderful primer, so if our audience is studying for board research or something of that sort, it's a terrific resource to go through. I have to tell you, this piece on the gut microbiome that you wrote is nothing short of a masterpiece. If you read this cover to cover, it's actually going to give you, I think, a sense of the current state and future state of the field. I wanted to start by just sort of beginning with sort of the origin story for a lot of this, which is this association between the gut microbiome and immunotherapy response. This takes us back several years to this pivotal series of papers in Science. Maybe you could walk our audience through that. Dr. Arielle Elkrief: Absolutely. Well, thank you so much for your kind words about the ASCO [Educational] Book. It was a team effort with a lot of key opinion leaders in the field, so I'm really glad to learn that you've liked it. Moving backwards in terms of how we came to understand that the gut microbiome is essential to priming a response to cancer immunotherapy actually goes back to 2015 and seminal papers that looked at what happens when we take mice that are germ-free mice that have never been exposed to a microbiome. These are mice that are born by cesarean section and essentially live in a bubble. And when we give those mice tumors and treat them, in the first papers with anti-CTLA-4 treatment, we realized that these antibodies don't work at all. And that was the first observation that the presence of a gut microbiome was essential to mounting an anti-cancer immune response. When we supplemented those same mice with beneficial bacteria or feces from responder patients, we were able to restore the response to immunotherapy. And so those were really the first preclinical observations that made us understand the critical role of the microbiome in immunotherapy response. Moving a little bit in the future, we examined the fecal microbiome composition using shotgun metagenomic sequencing in different cohorts of patients with solid tumors, namely lung cancers, kidney cancers, and also skin tumors like melanoma, and found that patients who responded to immunotherapy had a distinct microbiome that was characterized by beneficial bacteria compared to patients who experienced resistance to immunotherapy that had a dysbiotic or diseased microbiome. Dr. Sumanta (Monty) Pal: So, you know, it's interesting, these techniques that we're using to sequence the gut, they're a little bit different. So I wonder if you can give the audience a quick primer on these techniques that you're so well versed in, shotgun metagenomic sequencing, 16S rRNA sequencing. If you had to describe this in 30 seconds, which is a tall task, how would you do that? Dr. Arielle Elkrief: That's a tall task. Much of what we know about the microbiome initially came from a technique called 16S rRNA sequencing. This is a technique that amplifies the 16S region and basically tells you at the genus level what's going on at the level of bacterial composition. This technique is fast, relatively cheap, and can be performed on a laptop computer, which is excellent. The problem is that it's prone to a lot of technical variations. Different primers might give you different results, and you're really limited at the genus resolution. You can't get a good resolution in terms of species, and we're learning that different species from the same genus might have different physiological properties, and the same thing goes at the strain level. So when we really zone in and look at inter-species changes, we're seeing that these actually have specific functions in the host. So that brings us to metagenomic sequencing, which is a whole genome sequencing, next-generation sequencing based method that looks at the whole composition and gives you information not only on bacteria, but you might also get fungal and viral properties. You can zoom in on the strain level. You can also get functional output, so we can examine what the metabolic properties of specific species or strains might look like. The negative aspects of shotgun metagenomic sequencing is that it takes a lot of computational power in order to analyze the results and it might take a little bit longer. And certainly, within the clinical setting, not something that's feasible yet. And that brings us to more novel point-of-care biomarker tools that we've collaborated in developing along with Dr. Laurence Zitvogel and Dr. Lisa Derosa at Gustave Roussy, that learning from the shotgun metagenomics results designed a probe using quantitative PCR which looks for this specific bacteria we know to be important and developed a ratio of harmful bacteria to beneficial bacteria. This is called the TOPOSCORE, and it actually is able to predict quite nicely the response to immunotherapy using a stool sample and a really good turnaround time of almost 72 hours. Dr. Sumanta (Monty) Pal: That was a perfect overview and a lot of information in a short amount of time. It also makes you take out your high school biology textbooks, doesn't it, to understand that the bacterial ribosome, right, is a different size and shape, and that's what we're sequencing here. But these techniques I think are incredibly important, and I'm glad you actually discussed this, this RT-PCR based strategy of calculating the TOPOSCORE. It lends itself to this phenomenon of dysbiosis, and I think for our audience, that's going to be an important term to understand as time goes on. There's the normal healthy gut and then there's this phenomenon of dysbiosis, which is, I guess, simply put, an unhealthy gut. But tell us about, you know, how often you see dysbiosis in a cancer patient, maybe versus a normal healthy adult. Dr. Arielle Elkrief: So, I think we can split up your question into two parts. One is we know from cohort studies and population level-based studies that the microbiome of patients with cancer is distinct from healthy patients or healthy people. And we know that because of the global composition. We also think that there are diversity metrics that lend themselves to being described as dysbiotic. But we do know that the microbiome of people with cancer is distinct from healthy volunteers. That's the first point. In terms of how frequently dysbiosis occurs in patients with cancer, it's not very well defined. We know that even among healthy people, there is a certain level of dysbiosis. Laurence in her talk mentioned that to be about 10% to 20%. And the other fascinating component is that when we're thinking about dysbiosis and the cancer associated microbiome, in terms of the species that are enriched, it's quite striking that a lot of these dysbiotic or negative bacteria are also found to be enriched in patients with metabolic disease, like cardiovascular disease, for example. And so it's unclear if dysbiosis is the cause or consequence, but there definitely seems to be a general pattern of disease when looking at the microbiome compared to healthy people. Dr. Sumanta (Monty) Pal: That's interesting. So, I'll tell you, my second favorite portion of your article, and I'll tell you my favorite portion as well in the context of this podcast, but my second favorite part was the section around antibiotic stewardship. You know, the utilization of antibiotics in a very pragmatic fashion amongst our patients. Can you describe why that's so critical in the context of the microbiome? Dr. Arielle Elkrief: Antibiotics can disrupt the gut microbiome composition. We know this from mouse studies, but also cohort studies of patients that are exposed to antibiotics. And most importantly, we know that patients who are exposed to antibiotics, either before or during the immunotherapy period, have significantly worse progression-free survival and overall survival to immunotherapy. And this is true for immunotherapy in the monotherapy setting, but also when combined with chemotherapy. What's striking is that when we look at patients who are just treated with chemotherapy, we don't see the negative outcome of antibiotics on outcome and progression-free survival and overall survival, suggesting that the negative impact of antibiotics on outcomes is really specific to immunotherapy backbones. The other important point is that this negative signal is maintained even after adjusting for standard prognostic variables in the specific malignancies that we're looking at. And then most importantly, at the mechanistic level, we were able to actually pinpoint the mechanism behind this antibiotic related dysbiosis. And we see this with a bloom of negative bacteria which induces a loss of MAd-CAM, which is an endothelial gut checkpoint immune marker, and that causes an efflux of immunosuppressive T cells, which are usually in the gut, to go straight into the tumor where they make the tumor unamenable to an immunotherapy response. And so now we finally have the mechanism as to why antibiotics are harmful and why we need to practice antibiotic stewardship. Dr. Sumanta (Monty) Pal: And just to be clear for the audience, I mean, if a patient needs antibiotics, they need antibiotics. But perhaps it just suggests that, and we have, I suppose, this predilection as oncologists, just for the minor cold or cough or what have you, we maybe should be a little bit more cognizant of whether or not antibiotics are truly necessary. Is that fair? Dr. Arielle Elkrief: Absolutely. So what we're advocating for is antibiotic stewardship, and this is the clear recommendation that we can make. So that means confirming a bacterial infection. If it's there and antibiotics are indicated, to choose the most narrow spectrum for the shortest course and constantly re-evaluate the indication of antibiotics. And of course, we need to work with our colleagues in infectious diseases who've done incredible work in antibiotic stewardship. And all along this process we also need to be mindful of other medications and polypharmacy, such as proton pump inhibitors or narcotics, for example, we think that these other medications which are frequently prescribed in our cancer population can also potentially have negative impacts on the microbiome and immunotherapy response. Dr. Sumanta (Monty) Pal: I think that's a terrific summary and big guidance for the audience. I promised you I'd tell you my favorite part of your article, and this is this huge table. I think the table is two and a half pages long, if I remember correctly, but it's an awesome table, and I highly recommend our audience to check this out. It lists literally every therapeutic trial for the microbiome under the sun. And so it begins with the approach of fecal microbiota transplant, which I'm going to ask you to tell us about in a second, but it also hinges on a lot of really cool sort of novel therapies, live bacterial products, mixes of different microbial products. Maybe take us through this whole approach of FMT (fecal microbiota transplantation). I actually wasn't aware of the dozens of trials that you listed there in this space. It seems like it's a very active area of research. Dr. Arielle Elkrief: Definitely. So, as you alluded to, FMT or fecal microbiota transplantation is the most well studied and direct way to modify the patient's microbiome. This technique aims to replace the patient's dysbiotic microbiome with that of a healthy microbiome, either from a healthy donor volunteer that's been heavily screened, or from a patient who experienced response to immunotherapy. And, as three landmark studies so far that have been published demonstrated the potential of FMT to reduce primary resistance or secondary resistance to immunotherapy, and this has been in melanoma. We also recently reported on the results of our FMT-LUMINate trial, which looked at patients with lung cancer and melanoma. Once again, FMT, when combined with immunotherapy was safe and led to a higher proportion of responses than we would normally expect. We're now also looking at randomized trials that have come out. So the first being the TACITO trial in kidney cancer, which compared FMT plus pembrolizumab and axitinib to placebo in patients with RCC, and again, FMT was safe and feasible and also led to an increased progression-free survival at one year, meeting the study's primary endpoint. And so, so far, there's a wealth of data really showing the promise of FMT when combined with immunotherapy, and we're now in the process of conducting larger randomized trials, including in melanoma with the CCTG (Canada Cancer Trials Group) in our ME17 or Canbiome2 trial, where we're going to be enrolling 128 patients with metastatic melanoma to receive FMT and standard of care immunotherapy compared to standard of care immunotherapy alone. Dr. Sumanta (Monty) Pal: You're very humble, so I've got to highlight for our audience. This was a mega grant that Arielle received to fund really the largest prospective exploration of FMT that will exist to date. So I'm really excited about that. I wish this was something we could participate in stateside. Before we jump into the other approach, which is live bacterial products and mixes thereof, where do you see FMT going? I think that one of the perceived challenges with FMT is that it's hard to implement, right? You need to have a really robust framework when it comes to gastroenterology, the preparation's challenging. Is there a way to envision FMT use being more generalized? Dr. Arielle Elkrief: Those are great questions. So we're lucky in Canada to work with pioneers in FMT, Michael Silverman, Saman Maleki, and John Lenehan in London, Ontario, who had this really robust FMT healthy donor screening program, which literally screens for every pathogen under the sun, and we haven't had any problems with feasibility or implementing FMT in Canada. But I think that once we're going to hopefully start doing larger scale, randomized phase three studies, that we might run into problems with scalability. And I think also with regards to reproducibility, and that's the feedback that we're getting from some regulatory authorities, especially at the level of the FDA, where there are some concerns around inter- and intra-donor variability because, of course, we can't guarantee that every fecal sample is going to be the same. So that has really pushed the field to think about other strategies, such as live biotherapeutic products which take modified FMT or bacteria from stools from either healthy donors or from responder patients and basically turn them into drugs that are regulated as drugs and can then be studied in the context of investigational new drugs or products. Dr. Sumanta (Monty) Pal: I like this and, you know, I do think that there's a future for it. We just have to kind of put our heads together and figure out how to get over all of these logistical hurdles, but, you know, I agree, I think your group and others have demonstrated, especially with this trial that you're fanning out all throughout Canada, that it can potentially be done. This is a topic that could probably go on for another couple of hours, right, especially based on the size of the table that you put together in this brilliant article, but tell us about live bacterial products or LBPs, as we call them these days. What's the current status, what's the future there? And maybe I'll give you less than two minutes here, although again, I realize it's a two-hour topic. Dr. Arielle Elkrief: You're probably better suited to speak about that because you've been one of the pioneers in terms of this. So we can think about LBPs in terms of single strain organisms, like CBM588 for an example, which your group did some amazing work in showing that, in a randomized setting, that this led to better responses than we would expect compared to just work with controls. We also know that LBPs can have multiple strains, up to 30. We're collaborating with a company called Cannabis Bioscience that is actually working on much larger communities of consortia. And so we're really excited about the direction that that's taking in terms of taking these LBPs and developing them from the drug perspective. In addition to LBPs, we know that there are other ways that we can change the microbiome, notably prebiotics, which are compounds which can have a beneficial impact on the microbiome. And one of these is camu camu, which I know your group is leading a clinical trial looking at camu camu and kidney cancer, and we're excited to see how that compares to FMT or LBPs, because that might be a potentially scalable alternative. Dr. Sumanta (Monty) Pal: That's awesome. What a terrific overview, and that was less than two minutes. I don't know how you did it. That's terrific. Arielle, this has been such an insightful conversation. I just want to thank you for, again, a terrific article in the ASCO Educational Book. I highly recommend all of our listeners to go there and check it out, and also for sharing all these terrific insights on the podcast today. Dr. Arielle Elkrief: Thank you so much, Monty. Dr. Sumanta (Monty) Pal: And thanks to our listeners, too. If you value the insights that you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Thanks, everyone. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers: Dr. Sumanta (Monty) Pal @montypal Dr. Arielle Elkrief Follow ASCO on social media: @ASCO on Twitter ASCO on Bluesky ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Sumanta (Monty) Pal: Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis Dr. Arielle Elkrief: Honoraria: AstraZenica, Bristol-Myers Squibb, Merck, EMD Serono Consulting or Advisory Role: Bristol-Myers Squibb Research Funding (Inst.): Kanvas Bioscience, AstraZeneca, Merck Other Relationship: Royal College of Surgeons and Physicians of Canada, Cedar's Cancer Center (Henry R. Shibata Fellowship), Canadian Institutes of Health Research (CIHR)
5213 風とあそぶ:) 20250822FRI 今日のCOVID-19・・・1741回目リスク回避は可能・・・■PCR nowhttps://pcrnow.jp■コロナ早期診断・治療|新型コロナは終わっていない| 塩野義製薬https://bit.ly/4kLQEV6■検証なきコロナ禍 ~いまこそ「下水サーベイランス」(北島正章さん・兪炳匡さん)【山岡純一郎のニッポンの崖っぷち】20250716https://youtu.be/jqPogTrB56Y?si=aJkT66VcHjKcCGpz■NO HATE 国会議員はデマ-差別を止め-人権と憲法を守る義務を果たしてください!https://bit.ly/4mk0uP6■「デマと差別が蔓延する社会を許しません」発表記者会見 中継配信(2025年7月28日)https://www.youtube.com/live/y3sE1_jZ_7U?si=HOjtgUZijVujs2_y■伊東英朗監督「サイレントフォールアウト」https://fallout22.comhttps://youtu.be/RbAgsVUyYtE?si=1sAVRyMrRzTHJ0py■隠されてきた米国の核被害 20年以上追い続けるワケ|ゲスト:伊東英朗(4/7)https://youtu.be/UrWh4xr07g4?si=2WQ1x9HmxAo2NzbA■サイレント・フォールアウト: アメリカ核実験を止めた女性たちとその真実https://amzn.to/46w1NWB■BREAKING! The New SARS-CoV-2 Variant, NB.1.8.1 is the Most Dangerous So Far Poses a Major Threat!https://www.thailandmedical.news/news/breaking-the-new-sars-cov-2-variant-nb-1-8-1-is-the-most-dangerous-so-far-and-poses-a-major-threat■札幌市下水サーベイランスhttps://www.city.sapporo.jp/gesui/surveillance.html■新型コロナ・季節性インフルエンザの流行状況速報値の活用例監修モデルナhttps://moderna-epi-report.jp/■全員が安全になるまで、誰も安全ではないNobody is safe until everybody is safe●WHOコロナ後遺症の方のためのガイドラインhttp://bit.ly/3kteZFv 日本語●職場復帰に関するガイドラインー英国産業衛生学会http://bit.ly/3ZWmipo 日本語■Flowflex フロウフレックス 抗原検査キットhttps://amzn.to/46LQ3wY■株式会社 CLEAIRhttps://cleair-w.com/■ゲノムに聞け 最先端のウイルスとワクチンの科学https://amzn.to/42pt7DH気合・気愛で555!!!アラキ:)KOJI ARAKI Art WorksCopyright KOJI ARAKI Art Works All Rights Reserved
Damian Anfile revine la o poveste, alături de mine. Povestim despre viața lui Ion Iliescu, urmărindu-i copilăria, adolescența, familia și relația cu aceaștia, ascensiunea sa în PCR, anii de studiu de la Moscova, relația cu familia Ceaușescu, acuzațiile ce-l privesc în legătură cu Revoluția din decembrie 1989, mineriadele, cele 3 mandate, viața de după politică și multe, multe altele.
On episode #87 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/31/25 – 8/18/25. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Adjuvanted recombinant zoster vaccine is effective against herpes zoster ophthalmicus, and is associated with lower risk of acute myocardial infarction and stroke in adults aged ≥50 years (CID) Bacterial Dalbavancin for Treatment of Staphylococcus aureus Bacteremia (JAMA) Propensity-Matched Comparison of Timely vs. Delayed Antibiotic Therapy in Stenotrophomonas maltophilia Pneumoni (OFID) The proportion of Treponema pallidum PCR-positive primary syphilis infections which are seronegative for syphilis (OFID) Cefixime versus benzathine penicillin G for the treatment of early syphilis (Journal of Antimicrobial Chemotherapy) Dalbavancin for Treatment of Staphylococcus aureus Bacteremia (JAMA) Fungal The Last of US Season 2 (YouTube) Parasitic Increasing Length of the Babesia Season in New England in the Climate Change Era (OFID) Ivermectin to Control Malaria (NEJM) Miscellaneous ACIP Recommendations Summary (CDC: Influenza) Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to frailty score (JID) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.
Are germs truly the villains of human health—or have we misunderstood the body's healing process from the very beginning? In this eye-opening episode of the Know Better | Do Better Podcast, Autumn sits down with Liev Dalton, founder of Beyond Terrain, to dismantle mainstream medical myths and reveal the truth behind the terrain paradigm. From pleomorphism and the flaws of PCR testing to ancestral wisdom and the body's natural detox processes, Liev uncovers why germ theory may be the greatest medical misdirection of our time—and how reclaiming your health starts with honoring your body, not fearing it. If you've ever questioned the medical system, wondered why symptoms keep coming back, or felt drawn to holistic, root-cause healing, this conversation will challenge everything you thought you knew about illness, microbes, and healing.
HIV, superbugs, and standards—oh my! In this episode of Absolute Gene-ius, we explore the frontier of infectious disease research with Dr. Jesús Mingorance, researcher at Hospital Universitario La Paz in Madrid. His research is translational and uses digital PCR, qPCR, sequencing, and more.Dr. Mingorance walks us through his application of ultra-sensitive PCR methods to track HIV-2 viral loads—particularly in challenging cases where standard assays fall short. He shares how digital PCR enabled detection in samples where conventional tests failed, and how it's becoming essential for assay calibration and microbial quantification. He also dives into the endemic challenges of carbapenem-resistant Klebsiella pneumoniae in hospitals, revealing the clinical and epidemiological importance of quantifying pathogen load within the microbiome.In the career corner, Dr. Mingorance recounts his unconventional journey—from humanities student to biologist inspired by a single sentence about DNA. With humor and honesty, he reflects on the patience needed in science, the value of good questions, and the importance of mentoring new scientists. “Biology is beautiful,” he reminds us. We agree.Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System.
Dean's Chat hosts, Drs. Jeffrey Jensen and Johanna Richey, welcome Dr. Joseph Coppola to the podcast! Dr. Coppola is a yound practitioner in Massachusetts, practicing in Community Health Centers in Lynn and Peabody. A fantastic discussion on underserved communities, the medical challenges, the creative ways care can be delivered, and the compassion and empathy he has for his patients. Joseph has been in education since 2012, teaching within the Boston Public Health Commission/Boston University School of Medicine. He taught Anatomy, Physiology, and Biology to high school students. His life long passion for teaching is evident. A graduate of the New York College of Podiatric Medicine in 2020, Dr. Coppola did his 3 year residency training in Podiatric Medicine and Surgery at the Metrowest Medical Center in Framingham, MA. We had a chance to talk about our Dean's Chat sponsor, Bako Diagnostics, as Dr. Coppola participated in the Bako Diagnostics Mini-Fellowship in April 2023. We discussed the intensive Dermatopathology rotation that focuses on the principles of Podiatric Dermatology. He learned different biopsy techniques, utilization of instruments with exposure to specialized testing such as ENFD, immunohistochemistry, mass spectrometry, and real time PCR interpretations of complex cases from the lower extremity. Enjoy!
In this episode of For Pet's Sake, Mark from Bella+Duke talks to Charlotte, head of clinical administration at Wormcount, about parasite prevention, faecal testing, and why targeted deworming is better than blanket treatment. Learn how to spot signs of worm infestations, why chemical dewormers don't provide long-term protection, and how PCR testing is revolutionizing parasite detection for pets. Charlotte also discusses zoonotic risks, the environmental impact of over-deworming, and the importance of routine testing for dogs of different lifestyles. If you're a pet owner looking to safeguard your dog's health, prevent resistant parasites, and understand modern parasite management, this episode is packed with essential insights.
Gut Health Over 40: Tiny Health's Microbiome, Longevity, and ResilienceClick On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Cheryl Sew Hoy - CEO of "Tiny Health"www.TinyHealth.comSocials: @Tiny.HeatlhPodcast Summary: Brad Williams (Over 40 Fitness Hacks) welcomed Cheryl, founder of Tiny Health, after first learning about her company through Crowd Health. Brad shared his personal journey with gut testing, food allergies, and how microbiome awareness changed his approach to health. He also mentioned his recent Tiny Health score of 82/100, which outperformed his family's results.Cheryl (age 42, mom of three) founded Tiny Health after her first child, born via C-section, developed eczema and food allergies linked to disrupted microbiome colonization.Determined to prevent the same issues, she researched microbiome science and saw improved outcomes with her next two children (both vaginal births, no allergies).Tiny Health began with a focus on baby gut health but was always designed to expand into longevity and adult health, supporting people through all stages of life.Today, Tiny Health powers gut testing not only for families but also for longevity clinics, health assessment companies, and even the Mayo Clinic.Microbiome Importance: 80% of the immune system is housed in the gut. Early life gut balance impacts long-term immune strength, allergy risk, metabolic health, and autoimmune conditions.Technology Advantage: Traditional stool tests (PCR) only detect targeted pathogens, while Tiny Health uses metagenomic sequencing to capture a complete, functional view of the microbiome, including beneficial bacteria and pathways.Scoring & Metrics: Results include overall gut scores, resilience scores, antibiotic resistance, and insights into digestion, immune function, and hormone regulation.Supplements vs. Food:Supplements can help correct imbalances short-term, but lasting gut health requires prebiotic fibers and diverse whole foods.Fermented foods and polyphenol-rich foods (like berries) boost diversity and resilience.Leaky Gut Explained: The gut lining acts like a castle wall; without enough butyrate (produced by fiber-digesting bacteria), food particles and pathogens can cross, triggering immune responses and food sensitivities.Resilience & Recovery: Antibiotics, infections, or travel (“Bali belly”) can disrupt the microbiome for months or longer. Retesting 4–6 weeks after such events helps measure recovery.Aging Microbiome: After 40, resilience decreases, making gut testing and diet/lifestyle adjustments more important.Red Meat & Alcohol: Red meat isn't inherently bad, but must be balanced with fiber to prevent protein fermentation issues. Alcohol negatively impacts gut health and sleep, but moderation and timing can help reduce effects.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at brad@over40fitnesshacks.com or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV
Pop Culture Revolution has moved to a new home! Absolute DMV Podcast Network! DJ Boss Player and Mori christened the new season! DJ Boss Player's wife brought cake and champagne to celebrate! They caught up on all the hot topics they missed since the last episode in May! And they took a "Deep Dive" into the topic of capitalism in the USA! And now we're going to have video content in addition to the audio distribution! Look out for it in the coming days! We're back with a new swag and better than EVER! Join the Revolution!
If you've been trying to conceive with low AMH, high FSH, diminished ovarian reserve (DOR), or poor egg quality and nothing seems to be working… or if you've experienced failed IVF cycles or unexplained pregnancy loss - this episode is for you. We're diving into one of the most overlooked infections that could be silently impacting your fertility: Ureaplasma. This commonly missed microbe can compromise egg quality, disrupt implantation, and contribute to early miscarriage, even when labs appear “normal.” Whether you're TTC naturally or preparing for an IVF or FET cycle, you'll learn: How Ureaplasma affects egg and embryo quality, implantation, and ovarian reserve Why this infection is often missed on standard fertility workups The importance of partner testing and treating both partners When and how to test for Ureaplasma The functional fertility approach we use at Fab Fertile to rebalance the vaginal and seminal microbiome for optimal conception If you've done “all the things” and still aren't seeing results, this episode may reveal a missing piece of your fertility puzzle. This episode is for you if: You're struggling to conceive naturally despite doing “all the right things.” You've had failed IVF transfers, poor egg quality, or low ovarian reserve without clear answers. You've experienced recurrent infections or unexplained pregnancy losses. 5 Key Points: Why Ureaplasma and Mycoplasma are often missed in standard fertility testing and why they matter for egg quality, implantation and pregnancy maintenance. How Ureaplasma can contribute to low AMH, high FSH, and diminished ovarian reserve by increasing inflammation in the reproductive tract and altering the vaginal microbiome. The link between Ureaplasma and recurrent miscarriage, failed IVF, and abnormal embryos, even when other tests are “normal”. The functional fertility approach to addressing Ureaplasma with targeted antimicrobials, vaginal microbiome restoration, and gut health support for natural and assisted conception. --- TIMESTAMPS [00:00:00] Intro: Ureaplasma's hidden role in fertility struggles, natural conception, failed IVF, low AMH, DOR, poor egg quality, and unexplained pregnancy loss. [00:01:00] Who this episode is for: Fertility challenges including low AMH, high FSH, DOR, RPL, recurrent infections, and unexplained infertility. [00:02:00] What is ureaplasma? Impact on vaginal and seminal microbiome, egg and sperm quality, inflammation, and implantation failure. [00:03:00] Who should get tested? Those with unexplained infertility, recurrent pregnancy loss, persistent infections, elevated CRP/ANA, poor IVF outcomes, or partner infection history. [00:04:00] Why microbiome testing matters: Gut, vaginal, and seminal microbiome panels uncover hidden infections missed by conventional testing. [00:05:00] Key red flags: Multiple failed IVF transfers, RPL after heartbeat confirmation, chronic vaginal/urinary symptoms, and abnormal semen analysis. [00:06:00] Testing methods: Functional medicine/nutrition, PCR, and microbiome panels (e.g., Juno Bio) versus limited conventional testing. [00:07:00] Supporting Fertility Success: Using biofilm disruptors and restoring balance in gut and vaginal microbiomes to improve egg quality and IVF outcomes. --- How to Get Started With Functional Fertility Support Book your call here to get your personalized plan and options to help improve pregnancy success either naturally or with IVF treatment. Check out our Fab Fertile functional fertility program here and learn how to improve AMH levels naturally. We work with couples that have low AMH, high FSH, diminished ovarian reserve, premature ovarian insufficiency, and recurrent pregnancy loss. --- RESOURCES Before Your IVF Transfer, Test This First: https://fabfertile.com/blogs/podcasts/before-your-ivf-transfer-test-this-first?_pos=4&_sid=c1bed4027&_ss=r IVF Prep with Low AMH: Boosting Your Chances for Success: https://fabfertile.com/blogs/podcasts/ivf-prep-with-low-amh-boosting-your-chances-for-success-1?_pos=1&_sid=2685fd59c&_ss=r Causes of Miscarriage Before 12 Weeks: What Most Doctors Miss: https://fabfertile.com/blogs/podcasts/causes-of-miscarriage-before-12-weeks-what-most-doctors-miss What You Need To Know About Chronic Infections And Infertility: https://fabfertile.com/blogs/podcasts/what-you-need-to-know-about-chronic-infections-and-infertility?_pos=2&_sid=1142152ce&_ss=r Our favorite fertility tracker Inito (use code FABFERTILE15 to save 15) Studies Today's study looks at Ureaplasma urealyticum, a common genital tract infection, and how it affects IVF. Researchers found it didn't affect fertilization or embryo quality but was linked to lower pregnancy rates after embryo transfer. The culprit? Infection in the endometrial lining which can disrupt implantation. So even if embryos look good Ureaplasma can still sabotage IVF success. https://academic.oup.com/humrep/article-abstract/6/5/727/609246?redirectedFrom=fulltext This study looked at whether Ureaplasma urealyticum in men's semen affects IVF. The results? Fertilization and pregnancy rates were the same for infected and uninfected men. But here's the thing, miscarriage rates were much higher in couples where the male partner had the infection. So Ureaplasma might not stop you from getting pregnant but it can increase the risk of losing the pregnancy. https://www.fertstert.org/article/S0015-0282(98)00472-5/fulltext Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH ---
FREEDOM - HEALTH - HAPPINESSThis podcast is highly addictive and seriously good for your health.SUPPORT DOC MALIK To make sure you don't miss any episodes, have access to bonus content, back catalogue, and monthly Live Streams, please subscribe to either:The paid Spotify subscription here: https://creators.spotify.com/pod/show/docmalik/subscribe The paid Substack subscription here: https://docmalik.substack.com/subscribeThank you to all the new subscribers for your lovely messages and reviews! And a big thanks to my existing subscribers for sticking with me and supporting the show! ABOUT THIS CONVERSATION: Attorney Tom Renz and I dig into the lies, fear tactics, and deep state manipulation that defined the COVID plandemic. From rigged PCR testing to the PREP Act's corporate immunity, we expose the fraud, call out weak leadership, and talk about the personal cost of fighting for truth and freedom. This is about courage, accountability, and the battle for our children's future.See my substack for more information.Much love, as always.Doc MalikLinksWebsite https://tomrenz.com/IMPORTANT INFORMATIONCONSULTATION SERVICEIn a world of rushed 7-minute consultations and endless referrals, I offer you something rare: time, context, and clear guidance.As your health advocate, I can help you:Understand your diagnosis and decode medical jargonDecide who to see: GP, specialist, osteopath, physio, accupuntcurist, homeopath etc?Break down treatment plans in plain, easy to understand non jargon EnglishPrepare for surgery, understand your risks, obtain true informed consent, and optimise yourself pre-op Recover from surgery, advise you how to heal faster and quicker and minimise post-op complicationsManage chronic illness with lifestyle, mindset, and dietary changesExplore holistic options that complement conventional careImplement lifestyle changes like fasting, stress reduction, or movementAsk better questions, and get real answersGet an unbiased second opinionReady to Take Control?If you're navigating a health concern, preparing for a big decision, or simply want to feel more confident in your path forward, I'd love to support you.Book here https://docmalik.com/consultations/ Because it's your body, your life, and your future. Let's make sure you're informed and heard.WaterpureI distill all my water for drinking, washing fruit and vegetables, and cooking. If you knew what was in tap water, so would you!https://waterpure.co.uk/docmalik BUY HERE TODAYHunter & Gather FoodsSeed oils are inflammatory, toxic and nasty; eliminate them from your diet immediately. Check out the products from this great companyhttps://hunterandgatherfoods.com/?ref=DOCHG BUY HERE TODAYUse DOCHG to get 10% OFF your purchase with Hunter & Gather Foods.IMPORTANT NOTICEIf you value my podcasts, please support the show so that I can continue to speak up by choosing one or both of the following options - Buy me a coffee If you want to make a one-off donation.Doc Malik Merch Store Check out my amazing freedom merch
Nesse episódio, o Dr. Vinícius Zofoli, intensivista e editor-chefe de terapia intensiva do portal Afya, discute como utilizar a ecocardiografia no contexto da PCR. Aperte o play e ouça agora! Confira esse e outros posts no Portal Afya e siga nossas redes sociais!FacebookInstagramLinkedinTwitter
Ready to get real about breast augmentation? In this episode, we're diving deep into the world of cosmetic surgery with a no-holds-barred conversation you won't want to miss! Today, Dr. Robert Whitfield speaks with a patient, Kathy Dixon, who's here to share her personal journey. Kathy opens up about how her cultural background shaped her decisions, her struggles with breast implant illness, and what led her to choose explant surgery. Tune in to hear so much more! Kathy's Business, Oh Yes Communications (https://www.ohyescommunications.com/author/kathy/) Show Highlights: Kathy's Cultural Influences & Decision for Augmentation (00:02:45) *Kathy discusses her Colombian heritage, body image, and initial decision to pursue breast augmentation. *Cultural Trends in Plastic Surgery (00:08:21) South American vs. U.S. beauty standards, Brazilian butt lifts, and safety concerns. Fat Transfer Misconceptions & Technical Details (00:09:11) Differences between fat transfer to buttocks, face, and breasts, and addresses misconceptions Kathy's Surgical Journey & Onset of Symptoms (00:16:29) *Kathy recounts her initial surgery, complications, and the gradual onset of physical and emotional symptoms. *Medical Dismissal & Search for Answers (00:18:36) Being dismissed by doctors, pursuing hormone testing, and discovering breast implant illness Testing, Mold, and Mycotoxins (00:20:34) High mold count; surgeon discusses PCR testing, bacterial contamination, and importance of thorough pathology Challenges in Women's Health & Medical Gaslighting (00:28:00) Lack of support for women, medical gaslighting, and inappropriate reliance on birth control for hormone issues Mold, Detoxification, and Environmental Factors (00:33:37) *Environmental and dietary sources of mold, detox challenges, and lifestyle changes *Post-Surgery Recovery & Lifestyle Adjustments (00:44:11) *Recovery goals, physical therapy, emotional healing, and the importance of support systems *Support Systems & Patient Experience (00:48:25) Importance of family support, patient education, and realistic expectations for recovery Links and Resources Let's Connect Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?t=8oQyjO25X5i&r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com Ultrahuman - Use code WHITFIELD10 for the most accurate wearable - https://www.ultrahuman.com/ring/buy/us/?affiliateCode=drwhitfield
Maryam Heinen is the author of Operation George Floyd. Get the book or documentary at www.maryamhenein.comLow Value Mail is a live call-in show with some of the most interesting guests the internet has to offer.Every Monday night at 7pm ETSupport The Show:
In this follow-up conversation with Raw Farm's CEO & Founder Mark McAfee, we explore the nuanced differences between raw milk and UV pasteurization technology. Mark shares his expert perspective on UV treatment as a middle ground between raw milk and traditional heat pasteurization, explaining why it preserves some bioactives while eliminating the beneficial bacterial diversity that makes raw milk unique.We dive into the technical aspects of milk safety, including Raw Farm's advanced PCR testing protocols that provide daily pathogen screening, and discuss the practical challenges of scaling raw milk production. Mark also shares his guide on how to source clean raw milk from your local farm. About Mark McAfeeMark McAfee founded the Raw Milk Institute (RAWMI) in 2011 to assure that farmers had a resource to assist them in producing very low risk raw milk for their consumers. Mark is passionate about “grass to glass” risk reduction management on the farm, and he believes that raw milk cannot emerge as a trusted food unless it is very low risk. He is certified in HACCP management from Chapman University and has developed and implemented award winning Food Safety Plans including Raw Milk Risk Analysis & Management Plans (“RAMP”).Links & ResourcesIntro to raw milk episode with Mark McAfee and Max KaneBob Comstock episode on UV pasteurization technologyGuide: How to Find a Good Raw Milk FarmerRaw milk finder: https://www.realmilk.com/raw-milk-finder/Raw Farm website: https://rawfarm.comCornell University 2021 study on bioactives in milkDiscounts Get 10% off delicious local farm-fresh food delivered to your door with my link for FarmMatch: https://farmmatch.com/jane Get 15% off high-quality Italian olive oil with code FARMTOFUTURE: https://shop.vignolifood.com/FARMTOFUTURE Get 40% the CircleDNA's Premium DNA test with code JANEZHANG: https://circledna.com/premium Connect with Jane Z. Instagram: @farm.to.future Email: jane@farmtofuture.co Website: farmtofuture.co
In this episode of The ICHE Podcast, we take a deep dive into the evolving role of plasma cell-free DNA (cfDNA) metagenomic next-generation sequencing (mNGS) in the diagnosis of infectious diseases. Hosted by experts from UCLA Health, this discussion breaks down what cfDNA mNGS is, how it differs from more traditional pathogen detection tools like PCR, and where it fits in the diagnostic landscape. Dr. Ishminder Kaur, Dr. Daniel Uslan, and Dr. Shangxin Yang join the episode to explore the clinical utility, benefits, and pitfalls of this rapidly emerging diagnostic modality. The group reviews several individual studies, highlighting how they approached their research questions, key findings, and the implications for patient care and antimicrobial stewardship. The conversation also addresses challenges such as interpreting complex results, cost considerations, and potential overuse. Whether you're a clinician, laboratorian, or infection preventionist, this episode provides critical insights into when and how cfDNA mNGS may enhance your diagnostic toolkit—and when it might not. Each guest closes with a practical takeaway: concrete advice for healthcare professionals who are considering incorporating cfDNA testing into their own clinical or infection control practice.
Can you detect Alzheimer's with a spit sample? That's the question driving Arianna Arbona's exciting research at Universidad Pablo de Olavide in Sevilla, Spain. In this episode of Absolute Gene-ius, she shares how she's isolating microvesicles from saliva and blood to identify early biomarkers for neurodegenerative diseases like Alzheimer's—an effort that could one day lead to minimally invasive diagnostic tools.Arianna describes the scientific and technical hurdles she's overcoming, from low vesicle concentrations to validating the brain-specific origin of those vesicles. She also reflects on her previous lupus research, where digital PCR enabled detection of faint mRNA signatures that qPCR missed—making it an essential tool for rare target quantification. Her future plans include integrating immuno-PCR and multiplex assays for more sensitive and multi-marker detection in Alzheimer's and beyond.In the career corner, Arianna recounts her journey from the Canary Islands to Helsinki to Sevilla, balancing passion, mentorship, and a healthy sense of humor. She talks about working through uncertainty after her master's degree, the mentors who kept her smiling, and how an early accidents taught her resilience. Her message to aspiring scientists: follow your curiosity and don't be afraid to change direction.Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System.
Jerneja Tomsic is a rebellious, outspoken gal (thank goodness) who carries a PhD in Molecular Biology. Being from Slovenia (as is Melania Trump), she knows about socialism... down to the untruths of science paradigms because she is in that world, is now awake and researches. From the lies of PCR tests being effective in diagnosing Co*v*d down to the truth of DNA/double helix, cancer, mammograms, viruses and bacteria.For the "Just Be Practice," Jerneja highlights how fear is the real virus.References for the show:https://viroliegy.comConversation on breast health:https://odysee.com/@Dawn-Lester:3/Conversation-with-Robyn---Jerneja:eLinks to Jerneja:Her Rumble channel: https://rumble.com/user/Jerneja18Chat with Kevin Corbett on PCR tests for The End of COVID project:https://odysee.com/@TheEndOfCovid:3/20230706-TEOC-TEOC-SESSION-The-PCR-Tests--Dr--Jerneja-Tomsic--Dr--Kevin-Corbett-MULTICAM-CUT-2-mov-by-NA:bThe Scientific Method:https://rumble.com/v59dcal-mwk-science-1-the-scientific-method-jerneja-tomsic.htmlPeer Review:https://rumble.com/v5b8wcd-mwk-science-2-peer-review-jerneja-tomsic.html*Host Eden Koz is a soul realignment specialist utilizing such gifts as psychological empathy, intuition, psychic ability, mediumship, meditation, mindset shift, Reiki, dimensional and galactic healing, to name a few. She can also perform a spiritual Co#id Vac+ Healing as well as remote & face-to-face sessions with individuals and groups. Contact info for Eden Koz / Just Be®, LLC:Website: EdenJustBe.com Socials: Insta, FB, FB (Just Be), LinkedIn Just Be~Spiritual BOOM Podcast can be found on the audio directories: Apple Podcasts, Spotify, Amazon Music, Stitcher, iHeart Radio, TuneIn+Alexa, ...
Many people struggling with chronic illness, fatigue, brain fog, or unexplained symptoms never find real answers because they're not addressing the root cause: cellular toxicity. In this episode, Dr. Robert Whitfield sits down with Dr. Daniel Pompa, a leading voice in cellular detox and functional medicine, to explore why so many people stay sick despite trying countless protocols. They break down how inflammation, toxic overload, and chemical exposure disrupt your body at the cellular level and what it actually takes to start healing. Whether you're dealing with hormonal imbalances, autoimmune symptoms, or post-explant recovery, this conversation is a must-listen for anyone interested in root-cause healing and natural detox strategies that work.
Stool testing technology has advanced rapidly in recent years, with newer methods like PCR and whole-genome sequencing offering faster and more precise insights into the gut microbiome. These innovations have transformed how clinicians approach gut health, allowing for more targeted interventions. However, older technologies—such as microscopy, culture, and enzyme-based assays—still play a valuable role. These methods provide functional insights that molecular tools may miss, such as direct observation of parasites or assessment of digestive markers. The most comprehensive labs recognize that no single method gives the full picture. Instead, combining the strengths of both modern and traditional techniques ensures more accurate, clinically meaningful results. In this episode, we dive into the pros and cons of different laboratory methodologies used in stool testing—from culture and microscopy to PCR and advanced sequencing. We break down how these choices impact accuracy, sensitivity, and clinical usefulness. You'll also learn why Genova Diagnostics stands out for its integrative, evidence-based approach, combining multiple testing methods to deliver the most comprehensive and clinically actionable results available. Today on The Lab Report: 4:00 Technology grows quickly, and the microbiome is complex 7:30 Microbiology culture 12:40 PCR – very precise if done correctly! 17:00 Interpreting the laundry list 20:10 Remember the microscope? 23:30 Whole-genome (shotgun) sequencing pros/cons 27:15 Genova does it all – and well Additional Resources: GI Effects Stool Profile Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.
In today's episode, we had the opportunity to speak with Henry M. Kuerer, MD, PhD, FACS, CMQ, about the potential to safely omit surgery in a subset of patients with early-stage HER2-positive or triple-negative breast cancer who achieve a pathologic complete response (pCR) following neoadjuvant systemic therapy. Dr Kuerer is a professor of breast surgical oncology at The University of Texas MD Anderson Cancer Center in Houston, Texas. In our conversation, Dr Kuerer reviewed the rationale behind a prospective phase 2 clinical trial (NCT02945579) testing image-guided vacuum-assisted core biopsy to identify patients with no residual disease after neoadjuvant therapy. He outlined the strict technical and eligibility criteria that enabled accurate detection of pCR—including tumors downsizing to less than 2 cm and biopsy of at least 12 cores from the tumor bed—and discussed why this biopsy-based approach may be more reliable than standard surgery in detecting residual disease. He also highlighted the broader clinical implications of the findings, noting that patients with biopsy-confirmed pCR may proceed directly to radiotherapy and avoid breast surgery altogether.
01:00:45 – 01:07:03UN-Backed One-World Climate Religion and Indoctrination in SchoolsCoverage details a global initiative to unite religions under environmentalism, replacing Judeo-Christian morality with “common values” aligned to Agenda 2030. Education systems, the Vatican, and the UN are identified as key actors in promoting this shift, with critiques of figures like Pope Francis and references to occultist influences on global spirituality. 01:21:14 – 01:29:28Homeschooling Crackdown and Christian Persecution in ChinaA deep dive into illegal homeschooling under China's communist regime, highlighting a pastor's defiance in educating his children biblically and the risks parents face, including imprisonment and loss of educational access. The narrative contrasts this with U.S. leniency and warns about potential future parallels. 02:07:33 – 02:14:5622 States Support Lawsuit Against School Over Gender Transition Without Parental ConsentA New Jersey father sues after his daughter is socially transitioned by school staff without his knowledge. The case raises questions about state overreach, parental rights, and the ideology embedded in public education, prompting a national coalition of states to intervene. 02:54:24 – 02:55:27Metadata Comparison to Obama's Birth Certificate Sparks Broader DistrustAnalysis of the Epstein footage metadata triggers comparisons to the Obama birth certificate controversy, where layered files were also detected. Critics suggest this pattern of digital tampering exposes a long-standing culture of government deceit and misuse of Adobe tools to fabricate documents. 03:01:38 – 03:04:21Trump Reverses on Epstein Files, Blames Political EnemiesTrump dismisses the Epstein files as fabricated by Democrats, despite having campaigned on releasing them. The narrative is described as a “mutual destruction” scenario implicating both parties, and his sudden shift is portrayed as preemptive damage control amid growing MAGA backlash. 03:06:51 – 03:08:09Epstein-Mossad Theory Reemerges Amid Trump Loyalty CriticismA claim resurfaces that Epstein worked for Israeli intelligence and acquired blackmail material on Trump. The connection is tied to Israeli elites like Ehud Barak and Les Wexner, with allegations that these ties explain Trump's consistent alignment with Israeli interests. 03:39:42 – 03:42:14Charges Dropped Against COVID Vaccine Skeptic Dr. Kirk MooreAttorney General Pam Bondi orders charges dismissed against Dr. Kirk Moore, who was accused of issuing fake COVID vaccine cards and destroying doses. The move is portrayed as a political concession to the MAGA base, with criticism of the government's original crackdown and praise for Moore's resistance to mandates. 03:56:19 – 03:57:09Push to Remove Vaccine Liability Protections and Enable LawsuitsAdvocates urge lawmakers to revoke immunity protections for vaccine makers and reclassify mRNA injections as gene-altering. The segment calls for retroactive lawsuits, arguing that only direct legal consequences will halt corporate harm. 03:57:47 – 03:58:32COVID Measures Blamed for More Harm Than Virus ItselfClaims are made that the "cure"—vaccines, ventilators, and Remdesivir—caused more deaths than COVID. The PCR test is mocked as unreliable, and the segment portrays pandemic policy as a coordinated scam by the healthcare system. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
01:00:45 – 01:07:03UN-Backed One-World Climate Religion and Indoctrination in SchoolsCoverage details a global initiative to unite religions under environmentalism, replacing Judeo-Christian morality with “common values” aligned to Agenda 2030. Education systems, the Vatican, and the UN are identified as key actors in promoting this shift, with critiques of figures like Pope Francis and references to occultist influences on global spirituality. 01:21:14 – 01:29:28Homeschooling Crackdown and Christian Persecution in ChinaA deep dive into illegal homeschooling under China's communist regime, highlighting a pastor's defiance in educating his children biblically and the risks parents face, including imprisonment and loss of educational access. The narrative contrasts this with U.S. leniency and warns about potential future parallels. 02:07:33 – 02:14:5622 States Support Lawsuit Against School Over Gender Transition Without Parental ConsentA New Jersey father sues after his daughter is socially transitioned by school staff without his knowledge. The case raises questions about state overreach, parental rights, and the ideology embedded in public education, prompting a national coalition of states to intervene. 02:54:24 – 02:55:27Metadata Comparison to Obama's Birth Certificate Sparks Broader DistrustAnalysis of the Epstein footage metadata triggers comparisons to the Obama birth certificate controversy, where layered files were also detected. Critics suggest this pattern of digital tampering exposes a long-standing culture of government deceit and misuse of Adobe tools to fabricate documents. 03:01:38 – 03:04:21Trump Reverses on Epstein Files, Blames Political EnemiesTrump dismisses the Epstein files as fabricated by Democrats, despite having campaigned on releasing them. The narrative is described as a “mutual destruction” scenario implicating both parties, and his sudden shift is portrayed as preemptive damage control amid growing MAGA backlash. 03:06:51 – 03:08:09Epstein-Mossad Theory Reemerges Amid Trump Loyalty CriticismA claim resurfaces that Epstein worked for Israeli intelligence and acquired blackmail material on Trump. The connection is tied to Israeli elites like Ehud Barak and Les Wexner, with allegations that these ties explain Trump's consistent alignment with Israeli interests. 03:39:42 – 03:42:14Charges Dropped Against COVID Vaccine Skeptic Dr. Kirk MooreAttorney General Pam Bondi orders charges dismissed against Dr. Kirk Moore, who was accused of issuing fake COVID vaccine cards and destroying doses. The move is portrayed as a political concession to the MAGA base, with criticism of the government's original crackdown and praise for Moore's resistance to mandates. 03:56:19 – 03:57:09Push to Remove Vaccine Liability Protections and Enable LawsuitsAdvocates urge lawmakers to revoke immunity protections for vaccine makers and reclassify mRNA injections as gene-altering. The segment calls for retroactive lawsuits, arguing that only direct legal consequences will halt corporate harm. 03:57:47 – 03:58:32COVID Measures Blamed for More Harm Than Virus ItselfClaims are made that the "cure"—vaccines, ventilators, and Remdesivir—caused more deaths than COVID. The PCR test is mocked as unreliable, and the segment portrays pandemic policy as a coordinated scam by the healthcare system. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHTFind out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
Having met at the UC Davis Wine Executive Program, Kia Behnia, CEO, and Mason Earles, CTO, founded Scout to replicate the best sensor in the vineyard, “the farmer's eye.” Leveraging off-the-shelf hardware, Scout uses AI to process images taken from a tractor to automate vineyard mapping, vine counting, yield forecasting, virus identification, and more. From managing vineyard assets to implementing precision agriculture to improve quality, Scout is harnessing the power of AI to optimize vineyard management.Detailed Show Notes: Mason's background - UC Davis Professor, Apple, AI & agricultureKia's background for Scout - owns the Neotempo wine brand, worked at Splunk, the “data for everything” companyThe official company name is Agricultural Scout, dba Scout, the website is agscout.ai, so it can be called any of those namesFounded in 2022, initially more hardware-based, but pivoted to an intelligence company using off-the-shelf hardwareThe goal is to “replicate the farmer's eye” with an AI-based solution using cameras, tractors, and Scout cloud and mobile app (which can be used offline); the brain is centered around a phoneUS only today (~50-100 clients, 300 blocks, 2M vines, processed 56M photos), going international in 20264 main use cases currently: Automate vine count, inventory, and mapping of vines - 4x faster than people could doEstimate crop performance - both vigor and fruitYield forecasting - can use every step in the growing season to forecast yield with historical performance and weather forecastsHealth performance and vine mapping - leveraging AI for virus detection3 types of clientsEstate wineriesVineyard management companies (“VMC”)Real estate investors or owners to track vineyardsBenefits include: $400-1,200 savings/acreProductivity gains through managing more acres with fewer people, identifying low-performing vines, and the program tells farmers where to sampleRemote monitoring of faraway vineyardsEarly season yield forecastingDisease management - virus can cause $170k/acre damage over 3-5 years, costs $40/PCR test, the goal is to keep virus 50 acresNeighborhood and AVA discountsStarter - 2 scan package (for inventory and virus)Professional - 6 scan packageTypical customer starts w/ 2 and upgrades to 6Monarch promotion, customers get 1 free scanUp front hardware costs ~$3,000New product in beta in July 2025 - ChatGPT Scout for vineyardsMarketing mostly through word of mouth, industry trade shows, and webinars have been effective, as has partnership with Monarch (already tech enthusiasts)Barriers to purchase are often due to farming budgets built around labor Hosted on Acast. See acast.com/privacy for more information.
Chagas disease is a dangerous tropical illness caused by single-cell parasites known as Trypanosoma cruzi. In most cases, if not treated immediately, the infection becomes chronic: the immune system of the host greatly reduces the number of parasites present in the body yet fails to fully eradicate them. Current diagnostic approaches often fail to detect these low numbers of parasites. A research team from the University of Georgia and others aimed to develop a test for cure. Joining me today is Rick Tarleton, PhD. Dr Tarleton ia a Regents' Professor at the University of Georgia and a Distinguished Professor in Biological Sciences in the Department of Cellular Biology. Serial ‘deep-sampling' PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected human, macaque, and canine hosts, and allows accurate monitoring of parasite load following treatment
Two Onc Docs, hosted by Samantha A. Armstrong, MD, and Karine Tawagi, MD, is a podcast dedicated to providing current and future oncologists and hematologists with the knowledge they need to ace their boards and deliver quality patient care. Dr Armstrong is a hematologist/oncologist and assistant professor of clinical medicine at Indiana University Health in Indianapolis. Dr Tawagi is a hematologist/oncologist and assistant professor of clinical medicine at the University of Illinois in Chicago. In this episode, OncLive On Air® partnered with Two Onc Docs to bring a discussion of key data from the phase 3 MATTERHORN trial (NCT04592913), which were presented at the 2025 ASCO Annual Meeting. MATTERHORN was a randomized, double-blind, multinational study evaluating the addition of durvalumab (Imfinzi) to FLOT (5-fluorouracil, leucovorin, oxaliplatin, and docetaxel) in patients with previously untreated, resectable gastric or gastroesophageal junction adenocarcinoma. In the MATTERHORN trial, 948 patients were randomly assigned 1:1 to receive either durvalumab or placebo in combination with perioperative FLOT, followed by 10 cycles of durvalumab or placebo as adjuvant therapy. The primary end point was event-free survival (EFS); secondary end points included overall survival (OS) and pathological complete response (pCR). The trial met its primary end point. Durvalumab plus FLOT (n = 474) significantly improved EFS vs placebo plus FLOT (n = 474; HR, 0.71; 95% CI, 0.58-0.86; P < .001), representing a 29% reduction in risk of progression, recurrence, or death. The interim OS analysis showed a nonsignificant trend favoring durvalumab (HR, 0.78; 95% CI, 0.62-0.97; P = .025). The pCR rate was 19% (95% CI, 15.75%-23.04%) with durvalumab vs 7.2% (95% CI, 5.02%-9.88%) with placebo. Toxicity profiles were comparable between the 2 groups, though immune-related adverse effects were more frequent with durvalumab. Importantly, the addition of durvalumab did not delay surgery or initiation of adjuvant therapy. Although the MATTERHORN regimen is not yet FDA approved or included in the National Comprehensive Cancer Network guidelines, this trial demonstrates a promising EFS benefit and potential practice-changing implications, pending mature OS data and further molecular subgroup analyses, according to Armstrong and Tawagi.
[01:02:32:15 - 01:03:00:26] — New COVID Variant “Nimbus” EmergesA new COVID-19 strain named NB.1.8.1 or "Nimbus" is spreading across Europe, the Americas, and the Pacific. Despite its presence, public reaction remains muted, and the WHO has struggled to reignite pandemic-level fear.[01:03:02:19 - 01:04:06:05] — COVID Death Stats & PCR Test ManipulationThe segment critiques how COVID deaths were reported, alleging that deaths from unrelated causes were labeled as COVID due to unreliable PCR tests. The fear was manufactured, not the illness itself.[01:06:50:17 - 01:07:40:08] — Nimbus Is Mild, But Messaging ContinuesDespite its spread, the WHO and CDC state that the Nimbus variant causes no more severe illness than previous strains. Symptoms are flu-like, but official guidance still pushes boosters and ongoing monitoring.[01:11:16:16 - 01:13:05:21] — RFK Jr. Challenges CNN on Vaccine TrialsRFK Jr. rebuts CNN's claims that childhood vaccines underwent placebo-controlled trials. He asserts that none used inert placebos and criticizes the CDC's licensing process for lacking true scientific rigor.[01:14:05:06 - 01:14:30:08] — Rise in Childhood Vaccines Since 1986Kennedy highlights that routine childhood shots have risen from 11 in 1986 to as many as 92 today. He argues this dramatic increase has occurred without sufficient safety testing, driven by profits over protection.[01:17:58:11 - 01:18:34:20] — CNN's Vaccine Trial Evidence DeconstructedRFK Jr. dissects CNN's list of 257 studies, explaining that the majority used active or post-licensure comparators, not inert placebos. He says the data actually supports his claims about inadequate safety trials.[01:28:18:00 - 01:28:42:14] — Vaccines, Chronic Illness, and AccountabilityHe argues that the explosion in autoimmune and chronic conditions among children should force a reevaluation of the vaccine schedule, especially products designed to alter the immune system without proper testing.[01:33:02:03 - 01:33:52:06] — Polio Cases Fell Before Vaccine RolloutData suggests polio mortality declined significantly before the vaccine was introduced. Kennedy and sources argue the impact of vaccines is overstated and that case definitions were changed to exaggerate success.[01:37:39:03 - 01:38:52:10] — Gardasil and the Dangers of Active PlacebosThe HPV vaccine Gardasil is cited as an example where placebo-controlled trials were misleading, as toxic aluminum adjuvants were used instead of inert substances. 90% of test subjects had adverse reactions.[01:47:08:10 - 01:48:07:20] — Clots in Children of Vaccinated MothersA disturbing case is reported of fibrous clots found in a 3-year-old born to a vaccinated mother. Additional studies suggest reduced IVF success and raise red flags about long-term generational health effects. [01:50:22:15 - 01:51:05:27] — Medical Gaslighting of Vaccine-Injured ChildrenA mother describes how her child became severely ill after vaccination, only to be dismissed by doctors who diagnosed her daughter with a psychological condition. Despite visible symptoms, she was offered antidepressants instead of real treatment.[01:51:49:14 - 01:52:18:05] — Parents Silenced, Doctors in DenialAcross the country, parents of vaccine-injured children say they are routinely ignored or belittled by medical professionals. RFK Jr. calls it a systematic campaign of gaslighting, protecting pharma over patients.[01:52:18:07 - 01:53:02:24] — CDC Profits from the Vaccines It PromotesRFK Jr. exposes the CDC's deep financial entanglement with the pharmaceutical industry—owning patents and earning royalties on vaccines—creating an undeniable conflict of interest.[01:54:07:21 - 01:54:54:02] — Government Pharma Pipeline: Vaccines for ProfitThe CDC, FDA, and NIH hold patents on dozens of vaccines and directly profit from licensing deals. These regulatory agencies now act as business partners to Big Pharma while maintaining a public image of oversight.[01:55:33:03 - 01:56:30:05] — The Hippocratic Oath Is DeadRFK Jr. accuses the medical establishment of abandoning its ethical foundation. He says doctors today are more concerned with protecting institutions than protecting patients, calling modern medicine morally bankrupt.[01:57:31:19 - 01:58:30:17] — Alarming Trends: Fertility Drops & Infant ClotsData from IVF clinics and anecdotal reports point to falling fertility and potential reproductive harms post-vaccination. A disturbing case involves a baby born with fibrous clots—raising fears of generational damage.[01:59:58:27 - 02:01:16:17] — Censorship That Kills: The Price of Silencing DissentRFK Jr. argues that medical censorship during COVID wasn't just wrong—it was deadly. Early treatments were discredited, expert voices silenced, and lives were lost in the name of “consensus.”[02:01:30:00 - 02:02:14:00] — Gold, Silver, and the Crumbling Dollar (Tony Arterburn)Tony Arterburn gives an update on the precious metals market, warning of long-term dollar instability. He explains how gold and silver remain reliable hedges against inflation and financial collapse, especially in times of political and institutional distrust03:13:23:17 – 03:14:07:04 — ICE Raids Expand NationwideTrump deploys ICE tactical units to five Democrat-controlled cities, including New York and Seattle, as Los Angeles goes into lockdown due to immigration riots. The move intensifies the administration's aggressive immigration crackdown.03:14:17:18 – 03:14:49:11 — Newsom Warns of Federal OverreachCalifornia Governor Gavin Newsom delivers an emotional speech warning that Trump's unilateral deployment of the National Guard could set a dangerous precedent, applying to every state and threatening democratic norms.03:27:43:17 – 03:28:42:22 — Mexican Official Talks Reclaiming U.S. LandA Mexican senator suggests reclaiming U.S. territory lost after the Treaty of Guadalupe Hidalgo, showing a historical map and implying that migration could serve as a tool to reassert Mexico's claim over the American Southwest.Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
[01:02:32:15 - 01:03:00:26] — New COVID Variant “Nimbus” EmergesA new COVID-19 strain named NB.1.8.1 or "Nimbus" is spreading across Europe, the Americas, and the Pacific. Despite its presence, public reaction remains muted, and the WHO has struggled to reignite pandemic-level fear.[01:03:02:19 - 01:04:06:05] — COVID Death Stats & PCR Test ManipulationThe segment critiques how COVID deaths were reported, alleging that deaths from unrelated causes were labeled as COVID due to unreliable PCR tests. The fear was manufactured, not the illness itself.[01:06:50:17 - 01:07:40:08] — Nimbus Is Mild, But Messaging ContinuesDespite its spread, the WHO and CDC state that the Nimbus variant causes no more severe illness than previous strains. Symptoms are flu-like, but official guidance still pushes boosters and ongoing monitoring.[01:11:16:16 - 01:13:05:21] — RFK Jr. Challenges CNN on Vaccine TrialsRFK Jr. rebuts CNN's claims that childhood vaccines underwent placebo-controlled trials. He asserts that none used inert placebos and criticizes the CDC's licensing process for lacking true scientific rigor.[01:14:05:06 - 01:14:30:08] — Rise in Childhood Vaccines Since 1986Kennedy highlights that routine childhood shots have risen from 11 in 1986 to as many as 92 today. He argues this dramatic increase has occurred without sufficient safety testing, driven by profits over protection.[01:17:58:11 - 01:18:34:20] — CNN's Vaccine Trial Evidence DeconstructedRFK Jr. dissects CNN's list of 257 studies, explaining that the majority used active or post-licensure comparators, not inert placebos. He says the data actually supports his claims about inadequate safety trials.[01:28:18:00 - 01:28:42:14] — Vaccines, Chronic Illness, and AccountabilityHe argues that the explosion in autoimmune and chronic conditions among children should force a reevaluation of the vaccine schedule, especially products designed to alter the immune system without proper testing.[01:33:02:03 - 01:33:52:06] — Polio Cases Fell Before Vaccine RolloutData suggests polio mortality declined significantly before the vaccine was introduced. Kennedy and sources argue the impact of vaccines is overstated and that case definitions were changed to exaggerate success.[01:37:39:03 - 01:38:52:10] — Gardasil and the Dangers of Active PlacebosThe HPV vaccine Gardasil is cited as an example where placebo-controlled trials were misleading, as toxic aluminum adjuvants were used instead of inert substances. 90% of test subjects had adverse reactions.[01:47:08:10 - 01:48:07:20] — Clots in Children of Vaccinated MothersA disturbing case is reported of fibrous clots found in a 3-year-old born to a vaccinated mother. Additional studies suggest reduced IVF success and raise red flags about long-term generational health effects. [01:50:22:15 - 01:51:05:27] — Medical Gaslighting of Vaccine-Injured ChildrenA mother describes how her child became severely ill after vaccination, only to be dismissed by doctors who diagnosed her daughter with a psychological condition. Despite visible symptoms, she was offered antidepressants instead of real treatment.[01:51:49:14 - 01:52:18:05] — Parents Silenced, Doctors in DenialAcross the country, parents of vaccine-injured children say they are routinely ignored or belittled by medical professionals. RFK Jr. calls it a systematic campaign of gaslighting, protecting pharma over patients.[01:52:18:07 - 01:53:02:24] — CDC Profits from the Vaccines It PromotesRFK Jr. exposes the CDC's deep financial entanglement with the pharmaceutical industry—owning patents and earning royalties on vaccines—creating an undeniable conflict of interest.[01:54:07:21 - 01:54:54:02] — Government Pharma Pipeline: Vaccines for ProfitThe CDC, FDA, and NIH hold patents on dozens of vaccines and directly profit from licensing deals. These regulatory agencies now act as business partners to Big Pharma while maintaining a public image of oversight.[01:55:33:03 - 01:56:30:05] — The Hippocratic Oath Is DeadRFK Jr. accuses the medical establishment of abandoning its ethical foundation. He says doctors today are more concerned with protecting institutions than protecting patients, calling modern medicine morally bankrupt.[01:57:31:19 - 01:58:30:17] — Alarming Trends: Fertility Drops & Infant ClotsData from IVF clinics and anecdotal reports point to falling fertility and potential reproductive harms post-vaccination. A disturbing case involves a baby born with fibrous clots—raising fears of generational damage.[01:59:58:27 - 02:01:16:17] — Censorship That Kills: The Price of Silencing DissentRFK Jr. argues that medical censorship during COVID wasn't just wrong—it was deadly. Early treatments were discredited, expert voices silenced, and lives were lost in the name of “consensus.”[02:01:30:00 - 02:02:14:00] — Gold, Silver, and the Crumbling Dollar (Tony Arterburn)Tony Arterburn gives an update on the precious metals market, warning of long-term dollar instability. He explains how gold and silver remain reliable hedges against inflation and financial collapse, especially in times of political and institutional distrust03:13:23:17 – 03:14:07:04 — ICE Raids Expand NationwideTrump deploys ICE tactical units to five Democrat-controlled cities, including New York and Seattle, as Los Angeles goes into lockdown due to immigration riots. The move intensifies the administration's aggressive immigration crackdown.03:14:17:18 – 03:14:49:11 — Newsom Warns of Federal OverreachCalifornia Governor Gavin Newsom delivers an emotional speech warning that Trump's unilateral deployment of the National Guard could set a dangerous precedent, applying to every state and threatening democratic norms.03:27:43:17 – 03:28:42:22 — Mexican Official Talks Reclaiming U.S. LandA Mexican senator suggests reclaiming U.S. territory lost after the Treaty of Guadalupe Hidalgo, showing a historical map and implying that migration could serve as a tool to reassert Mexico's claim over the American Southwest.Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
For years, scientists thought nothing could live above 73℃/163℉. At that temperature, everything boiled to death. But scientists Tom Brock and Hudson Freeze weren't convinced. What began as their simple quest to trawl for life in some of the hottest natural springs on Earth would, decades later, change the trajectory of biological science forever, saving millions of lives—possibly even yours.This seismic, totally unpredictable discovery, was funded by the U.S. government. This week, as the Trump administration slashes scientific research budgets en masse, we tell one story, a parable about the unforeseeable miracles that basic research can yield. After that, a familiar voice raises some essential questions: what are we risking with these cuts? And can we recover?Special thanks to Joanne Padrón Carney, Erin Heath, Valeria Sabate, Gwendolyn Bogard, Meredith Asbury and Megan Cantwell at AAAS. Thank you as well to Gregor Čavlović and Derek Muller and the rest of the Veritasium team.EPISODE CREDITS: Reported by - Latif Nasserwith help from - Maria Paz GutiérrezProduced by - Sarah Qari and Maria Paz GutiérrezOriginal music and sound design and mixing from - Jeremy BloomFact-checking by - Emily Kreigerand Edited by - Alex Neason with help from Sarah QariEPISODE CITATIONS:Videos - Latif also helped make a version of this story with the YouTube channel Veritasium. Articles - Hudson Freeze NYT OPED: Undercutting the Progress of American ScienceBooks -Thomas Brock, A Scientist in Yellowstone National ParkPaul Rabinow's Making PCR: A Story of BiotechnologyPodcasts Episodes:If you haven't heard, listen to our first episode about the Golden Goose awards. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.Leadership support for Radiolab's science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.