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I'm never excited when I diagnose a cat with anaemia: vague signs, confusing diagnostics, and what feels like a not-so-great prognoses. But are they really that hopeless?In this episode, feline medicine specialist Dr Rachel Korman joins us demystify the anaemic cat and offer a clear, practical diagnostic framework that will give you more confidence and better outcomes the next time you see a cat with a low PCV.Some highlights from this conversation:A step-by-step approach to categorising anaemia.Regenerative vs. non-regenerative: what it actually means in cats, and how to interpret the data.Why IMHA in cats doesn't look like IMHA in dogs — and how to recognise it.Haemoplasma infections (like Mycoplasma): When to treat, how to treat, PCR testing, and what the results really tell you.Age-specific differentials: what to prioritise in young vs. older cats.Supportive care: what works, what's myth.Prognosis pitfalls: why PCV alone doesn't predict survival.This episode will help you approach feline anaemia with more clarity, structure, and - dare we say - optimism.
What's the best gift you can give? To the millions of people whose lives have been saved by complete strangers, the answer would be simple: blood. But what exactly happens when blood has been donated, and how do we know it is safe? We chat to Dr Richard Mayne from Oxford's Experimental Medicine Division about genomics, Next-Generation Sequencing, blood screening (...and Star Trek). Could you be a blood-donating hero? Blood stocks are currently critically low, with the NHS Blood and Transplant (NHSBT) group in urgent need of new donors. Click here, and you'll be on your way to saving lives: https://www.blood.co.uk/news-and-campaigns/campaigns/blood-donor-appeal/
In this Mol Bio Minutes episode, Laurynas Alijošius shares a personal story that every molecular biologist can relate to—running PCR, cloning, and sequencing, only to discover frustrating errors in the DNA. This episode dives deep into PCR accuracy and why it matters for everything from sequencing to cloning and long-read library prep. Laurynas breaks down the major contributors to PCR error, including the fidelity of DNA polymerase, primer design flaws, template impurities, and suboptimal cycling conditions. He then offers a range of solutions—like switching to high-fidelity enzymes, using ready-to-go master mixes, and optimizing magnesium ion concentrations. He also explains how reducing cycle numbers and fine-tuning annealing temperatures can minimize unwanted amplification and ensure more reliable data.Whether you're troubleshooting or proactively optimizing your workflow, this episode is packed with tips and tools to help you increase PCR accuracy, reduce costs, and save time. Episode notes contain links to enzyme comparisons, primer design tools, and cycling guides to help you PCR with precision.Helpful resource links mentioned in this episode:Thermo Scientific web tools for primer design and analysis, and moreThe PCR Learning Center with lots of helpful tips and informationLearn more about PCR reagents and enzymesBrowse and purchase PCR enzymes and master mixesAccess the PCR troubleshooting guideDownload the molecular biology handbook Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague. Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.
Dr. Allison Zibelli and Dr. Rebecca Shatsky discuss advances in breast cancer research that were presented at the 2025 ASCO Annual Meeting, including a potential new standard of care for HER2+ breast cancer, the future of ER+ breast cancer management, and innovations in triple negative breast cancer therapy. Transcript Dr. Allison Zibelli: Hello and welcome to the ASCO Daily News Podcast. I'm Dr. Allison Zibelli, your guest host of the podcast today. I'm an associate professor of medicine and a breast medical oncologist at the Sidney Kimmel Comprehensive Cancer Center at Jefferson Health. There was a substantial amount of exciting breast cancer data presented at the 2025 ASCO Annual Meeting, and I'm delighted to be joined by Dr. Rebecca Shatsky today to discuss some of these key advancements. Dr. Shatsky is an associate professor of medicine at UC San Diego and the head of breast medical oncology at the UC San Diego Health Moores Cancer Center, where she also serves as the director of the Breast Cancer Clinical Trials Program and the Inflammatory and Triple-Negative Breast Cancer Program. Our full disclosures are available in the transcript of this episode. Dr. Shatsky, it's great to have you on the podcast today. Dr. Rebecca Shatsky: Thanks, Dr. Zibelli. It's wonderful to be here. Dr. Allison Zibelli: So, we're starting with DESTINY-Breast09, which was trastuzumab deruxtecan and pertuzumab versus our more standard regimen of taxane, trastuzumab pertuzumab for first-line treatment of metastatic HER2-positive breast cancer. Could you tell us a little bit about the study? Dr. Rebecca Shatsky: Yeah, absolutely. So, this was a long-awaited study. When T-DXd, or trastuzumab deruxtecan, really hit the market, a lot of these DESTINY-Breast trials were started around the same time. Now, this was a global, randomized, phase 3 study presented by Dr. Sara Tolaney from the Dana-Farber Cancer Institute of Harvard in Boston. It was assessing essentially T-DXd in the first-line setting for metastatic HER2-positive breast cancer in addition to pertuzumab. And that was randomized against our standard-of-care regimen, which was established over a decade ago by the CLEOPATRA trial, and we've all been using that internationally for at least the past 10 years. So, this was a large trial, and it was one-to-one-to-one of patients getting T-DXd plus pertuzumab, T-DXd alone, or THP, which mostly is used as docetaxel and trastuzumab and pertuzumab every three weeks for six cycles. And this was in over 1,000 patients; it was 1,159 patients with metastatic HER2-positive breast cancer. This was a very interesting trial. It was looking at the use of trastuzumab deruxtecan, but patients were started on this treatment for their first-line metastatic HER2-positive breast cancer with no end date to their T-DXd. So, it was, you know, you were started on T-DXd every 3 weeks until progression. Now, CLEOPATRA is a little bit different than that, though, as we know. So, CLEOPATRA has a taxane plus trastuzumab and pertuzumab. But generally, patients drop the taxane after about six to seven cycles because, as we know, you can't be really on a taxane indefinitely. You get pretty substantial neuropathy as well as cytopenias, other things that end up happening. And so, in general, that regimen has sort of a limited time course for its chemotherapy portion, and the patients maintained after the taxane is dropped on their trastuzumab and their pertuzumab, plus or minus endocrine therapy if the investigator so desires. And the primary endpoint of the trial was progression-free survival by blinded, independent central review (BICR) in the intent-to-treat population. And then it had its other endpoints as overall survival, investigator-assessed progression-free survival, objective response rates, and duration of response, and of course, safety. As far as the results of this trial, so, I think that most of us key opinion leaders in breast oncology were expecting that this was going to be a positive trial. And it surely was. I mean, this is a really, really active drug, especially in HER2-positive disease, of course. So, the DESTINY-Breast03 data really established that, that this is a very effective treatment in HER2-positive metastatic breast cancer. And this trial really, again, showed that. So, there were 383 patients that ended up on the trastuzumab plus deruxtecan plus pertuzumab arm, and 387 got THP, the CLEOPATRA regimen. What was really interesting also to note of this before I go on to the results was that 52% of patients on this trial had de novo metastatic disease. And that's pretty unusual for any kind of metastatic breast cancer trial. It kind of shows you, though, just how aggressive this disease is, that a lot of patients, they present with de novo metastatic disease. It's also reflecting the global nature of this trial where maybe the screening efforts are a little bit less than maybe in the United States, and more patients are presenting as later stage because to have a metastatic breast cancer trial in the United States with 52% de novo metastatic disease doesn't usually happen. But regardless, the disease characteristics were pretty well matched between the two groups. 54% of the patients were triple positive, or you could say hormone-positive because whether they were PR positive or ER positive and PR negative doesn't really matter in this disease. And so, the interim data cutoff was February of this year, of 2025. So, the follow-up so far has been about 29 months, so the data is still really immature, only 38% mature for progression-free survival interim analysis. But what we saw is that T-DXd plus pertuzumab, it really improved progression-free survival. It had a hazard ratio that was pretty phenomenal at 0.56 with a confidence interval that was pretty narrow of 0.44 to 0.71. So, very highly statistically significant data here. The progression-free survival was consistent across all subgroups. Overall survival, very much immature at this time, but of course, the trend is towards an overall survival benefit for the T-DXd group. The median durable response with T-DXd plus pertuzumab exceeded 3 years. Now, importantly, though, I want to stress this, is grade 3 or above treatment-emergent adverse events occurred in both subgroups pretty equally. But there were 2 deaths in the T-DXd group due to interstitial lung disease. And there was a 12.1% adjudicated drug-induced interstitial lung disease/pneumonitis event rate in the T-DXd group and only 1%, and it was grade 1-2, in the THP group. So, that's really the caveat of this therapy, is we know that a percentage of patients are going to get interstitial lung disease, and that some may have very serious adverse events from it. So, that's always something I keep in the back of my mind when I treat patients with T-DXd. And so, overall, the conclusions of the trial were pretty much a slam dunk. T-DXd plus pertuzumab, it had a highly statistically significant and clinically meaningful improvement in progression-free survival versus the CLEOPATRA regimen. And that was across all subgroups for first-line metastatic HER2-positive breast cancer here. And so, yeah, the data was pretty impressive. Just to go into the overall response rate, because that's always super important as well, you had 85.1% of patients having a confirmed overall RECIST response rate in the T-DXd plus pertuzumab group and a 78.6 in the CLEOPATRA group. The complete CR rate, complete response was 15.1% in the T-DXd group and 8.5 in the CLEOPATRA regimen. And it was really an effective regimen in this group, of course. Dr. Allison Zibelli: So, the investigators say at the end of their abstract that this is the new standard of care. Would you agree with that statement? Dr. Rebecca Shatsky: Yeah, that was a bold statement to make because I would say in the United States, not necessarily at the moment because the quality of life here, you have to think really hard about. Because one thing that's really important about the DESTINY-Breast09 data is that this was very much an international trial, and in many of the countries where patients enrolled on this, they were not able to access T-DXd off trial. And so, for them, this means T-DXd now or potentially never. And so, that is a really big difference whereas internationally, that may mean standard of care. However, in the US, patients have no issues accessing T-DXd in the second- or third-line settings. And right now, it's the standard of care in the second line in the United States, with all patients basically getting this second-line therapy except for some unique patients where they may be doing a PATINA trial regimen, which we saw at San Antonio Breast Cancer in 2024 of the triple-positive patients getting hormonal therapy plus palbociclib, which had a really great durable response. That was super impressive as well. Or there is the patient that the investigator can pick KADCYLA because the patient really wants to preserve their hair or maybe it's more indolent disease. But the quality of life on T-DXd indefinitely in the first-line setting is a big deal because, again, that CLEOPATRA regimen allows patients to drop their chemotherapy component about five to six months in. And with this, you're on a drug that feels very chemo-heavy indefinitely. And so, I think there's a lot more to investigate as far as what we're going to do with this data in the United States because it's a lot to commit a patient in the first-line metastatic setting. These de novo metastatic patients, some of them may be cured, honestly, on the HER2-targeting regimen. That's something we see these days. Dr. Allison Zibelli: So, very interesting trial. I'm sure we'll be talking about this for a long time. So, let's move on to SERENA-6, which was, I thought, a very interesting trial. This trial took patients with ER positive, advanced breast cancer after six months on an AI (aromatase inhibitor) and a CDK4/6 inhibitor. They did ctDNA every two to three months, and when they saw an ESR1 mutation emerge, they changed half of the patients to camizestrant plus CDK4/6 and kept the other half on the AI plus CDK4/6. Can you talk about that trial a little bit, please? Dr. Rebecca Shatsky: Yeah, so this was a big trial at ASCO25. This was presented as a Plenary Session. So, this was camizestrant plus a CDK4/6 inhibitor, and it could have been any of the three, so palbo, ribo, or abemaciclib in the first-line metastatic hormone-positive population, and patients were on an AI with that. They were, interestingly, tested by ctDNA at baseline to see if they had an ESR1 mutation. So, that was an interesting feature of this trial. But patients had to have already been on their CDK4/6 inhibitor plus AI for at least 6 months to enroll. And then, as you mentioned, they got ctDNA testing every 2 to 3 months. This was also a phase 3, double-blind, international trial. And I do want to highlight again, international here, because that's important when we're considering some of this data in the U.S. because it influences some of the results. So, this was presented by Dr. Nick Turner of the Royal Marsden in the UK. So, just a little bit of background for our listeners on ESR1 mutations and why they're important. This is the most common, basically, acquired resistance mutation to patients being treated with aromatase inhibitors. We know that treatment with aromatase inhibitors can induce this. It makes a conformational change in the estrogen receptor that makes the estrogen receptor constitutively active, which allows the cell to signal despite the influence of the aromatase inhibitor to decrease the estrogen production so that the ligand binding doesn't matter as much as far as the cell signaling and transcription is concerned. And camizestrant, you know, as an oral SERD, just to explain that a little bit too; these are estrogen receptor degraders. The first-in-class of a selective estrogen receptor degrader to make it to market was fulvestrant. And that's really been our standard-of-care estrogen degrader for the past 25 years, almost 25 years. And so, a lot of us are just looking for some of these oral SERDs to replace that. But regardless, they do tend to work in the ESR1-mutated population. And we know that patients on aromatase inhibitors, the estimates of patients developing an ESR1 mutation, depending on which study you look at, somewhere between 30% to 50% overall, patients will develop this mutation with hormone-positive metastatic breast cancer. There is a small percentage of patients that have these at baseline without even treatment of an aromatase inhibitor. The estimates of that are somewhere between 0.5 and up to 5%, depending on the trial you look at and the population. But regardless, there is a chance someone on their CDK4/6 inhibitor plus AI at 6 months' time course could have had an ESR1 mutation at that time. But anyway, so they got this ctDNA every 2 to 3 months, and once they were found to develop an ESR1 mutation, the patients were then switched to the oral SERD. AstraZeneca's version of the oral SERD is camizestrant, 75 mg daily. And then their type of CDK4/6 inhibitor was maintained, so they didn't switch the brand of their CDK4/6 inhibitor, importantly. And that was looked at then for progression-free survival, but these were patients with measurable disease by RECIST version 1.1. And the data cut off here was November of 2024. This was a big trial, you know, and I think that that's influential here because this was 3,256 patients, and that's a lot of patients. So, they were all eligible. And then 315 patients ended up being randomized to switch to camizestrant upon presence of that ESR1 mutation. So, that was 157 patients. And then the other half, so they were randomized 1:1, they continued on their AI without switching to an oral SERD. That was 158 patients. They were matched pretty well. And so, their baseline characteristics, you know, the two subgroups was good. But this was highly statistically significant data. I'm not going to diminish that in any way. Your hazard ratio was 0.44. Highly statistically significant confidence intervals. And you had a median progression-free survival in those that switched to camizestrant of 16 months, and then the non-switchers was 9.2 months. So, the progression-free survival benefit there was also consistent across the subgroups. And so, you had at 12 months, the PFS rate was 60.7% for the non-treatment group and 33.4% in the treatment group. What's interesting, though, is we don't have overall survival data. This is really immature, only 12% mature as far as overall survival. And again, because this was an international trial and patients in other countries right now do not have the access to oral SERDs that the United States does, the crossover rate, they were not allowed to crossover, and so, a very few patients, when we look at progression-free survival 2 and ultimately overall survival, were able to access an oral SERD in the off-trial here and in the non-treatment group. And so, that's really important as far as we look at these results. Adverse events were pretty minimal. These are very safe drugs, camizestrant and all the other oral SERDs. They have some mild toxicities. Camizestrant is known for something weird, which is called photopsia, which is some flashing lights in the periphery of the eye, but it doesn't seem to have any serious clinical significance that we know of. It has a little bit of bradycardia, but it's otherwise really well tolerated. You know, I hate to say that because that's very subjective, right? I'm not the one taking the drug. But it doesn't have any serious adverse events that would cause discontinuation. And that's really what we saw in the trial. The discontinuation rates were really low. But overall, I mean, this was a positive trial. SERENA-6 showed that switching to camizestrant at the first sign of an ESR1 mutation on CDK4/6 inhibitor plus AI improved progression-free survival. That's all we can really say from it right now. Dr. Allison Zibelli: So, let's move on to ASCENT-04, which was a bit more straightforward. Sacituzumab govitecan plus pembrolizumab versus chemotherapy plus pembrolizumab in PD-L1-positive, triple-negative breast cancer. Could you talk about that study? Dr. Rebecca Shatsky: Yeah, so this was also presented by the lovely Sara Tolaney from Dana-Farber. And this study made me really excited. And maybe that's because I'm a triple-negative breast cancer person. I mean, not to say that I don't treat hundreds of patients with hormone- positive, but our unmet needs in triple negative are huge because this is a disease where you have got to throw your best available therapy at it as soon as you can to improve survival because survival is so poor in this disease. The average survival with metastatic triple-negative breast cancer in the United States is still 13-18 months, and that's terrible. And so, for full disclosure, I did have this trial open at my site. I was one of the site PIs. I'm not the global PI of the study, obviously. So, what this study was was for patients who had had at least a progression-free survival of 6 months after their curative intent therapy or de novo metastatic disease. They were PD-L1 positive as assessed by the Dako 22C3 assay of greater than or equal to a CPS score of 10. So, that's what the KEYNOTE-355 trial was based on as well. So, standard definition of PD-L1 positive in breast cancer here. And basically, these patients were randomized 1:1 to either their sacituzumab govitecan plus pembrolizumab, day 1 they got both therapies, and then day 8 just the saci, as is standard for sacituzumab. And then the other group got the KEYNOTE-355 regimen. So, that is pembrolizumab with – your options are carbogem there, paclitaxel or nab-paclitaxel. And it's up to investigator's decision which upon those they decided. They followed these patients for disease progression or unacceptable toxicity. It was really an impressive trial in my opinion because we know already that this didn't just improve progression-free survival, because survival is so poor in this disease, of course, we know that it improved overall survival. It's trending towards that very much, and I think that's going to be shown immediately. And then the objective response rates were better, which is key in this disease because in the first-line setting, you've got a lot of people who, especially your relapsed TNBC that don't respond to anything. And you lose a ton of patients even in the first-line setting in this disease. And so, this was 222 patients to chemotherapy and pembro and 221 to sacituzumab plus pembro. Median follow-up has only been 14 months, so it's still super early here. Hazard ratio so far of progression-free survival is 0.65, highly statistically significant, narrow confidence intervals. And so, the median duration of response here for the saci group was 16.5 months versus 9.2 months. So, you're getting a 7-month progression-free survival benefit here, which in triple negative is pretty fantastic. I mean, this reminds me of when we saw the ASCENT data originally come out for sacituzumab, and we were all just so happy that we had this tool now that doubled progression-free and overall survival and made such a difference in this really horrible disease where patients do poorly. So, OS is technically immature here, but it's really trending very heavily towards improvement in overall survival. Importantly, the treatment-related adverse events in this, I mean, we know sacituzumab causes neutropenia, people who are experienced with this drug know how to manage it at this point. There wasn't any really unexpected treatment-related adverse events. You get some people with sacituzumab who have diarrhea. It's usually pretty manageable with some Imodium. So, it was cytopenias predominantly in this disease in this population that were highlighted as far as adverse events. But I'm going to be honest, like I was surprised that this wasn't the plenary over the SERENA-6 data because this, in my mind, there we have a practice-changing trial. I will immediately be trying to use this in my PD-L1 population because, to be honest, as a triple-negative breast cancer clinical specialist, when I get a patient with metastatic triple-negative breast cancer who's PD-L1 positive, I think, "Oh, thank God," because we know that part of the disease just does better in general. But now I have something that really could give them a durable response for much longer than I ever thought possible when I started really heavily treating this disease. And so, this was immediately practice-changing for me. Dr. Allison Zibelli: I think that it's pretty clear that this is at least an option, if not the option, for this group of patients. Dr. Rebecca Shatsky: Yeah, the duration of responses here was – it's just really important because, I mean, I do think this will make people live longer. Dr. Allison Zibelli: So, moving on to the final study that we're going to discuss today, neoCARHP (LBA500), which was neoadjuvant taxane plus trastuzumab, pertuzumab, plus or minus carbo(platin) in HER2-positive early breast cancer. I think this is a study a lot of us have been waiting for. What was the design and the results of this trial? Dr. Rebecca Shatsky: I was really excited about this as well because I'm one of those people that was waiting for this. This is a Chinese trial, so that is something to take note of. It wasn't an international trial, but it was a de-escalation trial which had become really popular in HER2-positive therapy because we know that we're overtreating HER2-positive breast cancer in a lot of patients. A lot of patients we're throwing the kitchen sink at it when maybe that is not necessary, and we can really de-escalate and try to personalize therapy a little bit better because these patients tend to do well. So, the standard of care, of course, in HER2-positive curative intent breast cancer with tumors that are greater than 2 cm is to give them the TCHP regimen, which is docetaxel, carboplatin, trastuzumab, and pertuzumab. And that was sort of established by several trials in the NeoSphere trial, and now it's been repeated in a lot of different studies as well. And so, that's really the standard of care that most people in the United States use for HER2-positive curative intent breast cancer. This was a trial to de-escalate the carboplatin, which I was super excited about because many of us who treat this disease a lot think carbo is the least important part of the therapy you're giving there. We don't really know that it's necessary. We've just been doing it for a long time, and we know that it adds a significant amount of toxicity. It causes thrombocytopenia, it causes severe nausea, really bad cytopenias that can be difficult in the last few cycles of this to manage. So, this trial was created. It randomized patients one to one with stage 2 and 3 HER2-positive breast cancer to either get THP, a taxane, pertuzumab, trastuzumab, similar to the what we do in first-line metastatic HER2-positive versus the whole TCHP with a carboplatin AUC of 6, which is what's pretty standard. And it was a non-inferiority trial, so important there. It wasn't to establish superiority of this regimen, which none of us, I think, were looking for it to. And it was a modified intent-to-treat population. And so, all patients got at least one cycle of this to be assessed as a standard for an intent-to-treat trial. And so, they assumed a pCR rate of about 62.8% for both groups. And, of course, it included both HER2-positive triple positives and ER negatives, which are, you know, a bit different diseases, to be honest, but we all kind of categorize them and treat them the same. And so, this trial was powered appropriately to detect a non-inferiority difference. And so, we had about 380 patients treated on both arms, and there was an absolute difference of only 1.8% of those treated with carbo versus those without. Which was fantastic because you really realized that de-escalation here may be something we can really do. And so, the patients who got, of course, the taxane regimen had fewer adverse events. They had way fewer grade 3 and 4 adverse events than the THP group. No treatment-associated deaths occur, which is pretty standard for- this is a pretty safe regimen, but it causes a lot of hospitalizations due to diarrhea, due to cytopenias, and neutropenic fever, of course. And so, I thought that this was something that I could potentially enact, you know, and be practice-changing. It's hard to say that when it's a trial that was only done in China, so it's not necessarily the United States population always. But I think for patients moving forward, especially those with, say, a 2.5 cm tumor, you know, node negative, those, I'd feel pretty comfortable not giving them the carboplatin here. Notes that I want to make about this population is that the majority were stage 2 and not stage 3. They weren't necessarily your inflammatory HER2-positive breast cancer patients. And that the taxane that was utilized in the trial is a little different than what we use in the United States. The patients were allowed to get nab-paclitaxel, which we don't have FDA approval for in the first-line curative intent setting for HER2-positive breast cancer in the United States. So, a lot of them got abraxane, and then they also got paclitaxel. We tend to use docetaxel every 3 weeks in the United States. So, just to point out that difference. We don't really know if that's important or not, but it's just a little bit different to the population we standardly treat. Dr. Allison Zibelli: So, are there patients that you would still give TCHP to? Dr. Rebecca Shatsky: Yeah, great question. I've been asked that a lot in the past like week since ASCO. I'd say in my inflammatory breast cancer patients, that's a group I do tend to sometimes throw the kitchen sink at. Now, I don't actually use AC in those because I know that that was the concern, but I think the TRAIN-2 trial really showed us you don't need to use Adriamycin in HER2-positive disease unless it's like refractory. So, I don't know that I would throw this on my stage 3C or inflammatory breast cancer patients yet because the majority of this were not stage 3. So, in your really highly lymph node positive patients, I'm a little bit hesitant to de-escalate them from the start. This is more of a like, if there's serious toxicity concerns, dropping carbo is absolutely fine here. Dr. Allison Zibelli: All right, great. Thank you, Dr. Shatsky, for sharing your valuable insights with us on the ASCO Daily News Podcast today. Dr. Rebecca Shatsky: Thanks so much, Dr. Zibelli and ASCO Daily News. I really want to thank you for inviting me to talk about this today. It was really fun, and I hope you find my opinions on some of this valuable. And so, I just want to thank everybody and my listeners as well. Dr. Allison Zibelli: And thank you to our listeners for joining us today. You'll find the links to all the abstracts discussed today in the transcript of this episode. Finally, if you like this podcast and you learn things from it, please take a moment to rate, review, and describe because it helps other people find us wherever you get your podcasts. Thank you again. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. More on today's speakers Dr. Allison Zibelli Dr. Rebecca Shatsky @Dr_RShatsky Follow ASCO on social media: @ASCO on Twitter @ASCO on Bluesky ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Allison Zibelli: No relationships to disclose Dr. Rebecca Shatsky: Consulting or Advisory Role: Stemline, Astra Zeneca, Endeavor BioMedicines, Lilly, Novartis, TEMPUS, Guardant Health, Daiichi Sankyo/Astra Zeneca, Pfizer Research Funding (Inst.): OBI Pharma, Astra Zeneca, Greenwich LifeSciences, Briacell, Gilead, OnKure, QuantumLeap Health, Stemline Therapeutics, Regor Therapeutics, Greenwich LifeSciences, Alterome Therapeutics
DNA to fundamentalny kod życia — niezwykle istotna, a zarazem niewidoczna gołym okiem cząsteczka chemiczna. Nawet najbardziej zaawansowane mikroskopy nie potrafią rozróżnić poszczególnych nukleotydów, które zapisują informacje biologiczne za pomocą czterech liter: A, T, C i G. Jak zatem odczytać ten kod chemiczny i przełożyć go na zapis literowy, który kojarzymy z DNA?W tym odcinku przybliżamy klasyczną metodę sekwencjonowania Sangera — precyzyjną technikę, która pozwala zrozumieć, jak zbudowany jest materiał genetyczny. Zaczynamy od absolutnych podstaw: struktury DNA, zasady komplementarności, działania enzymu polimerazy DNA i mechanizmu reakcji PCR, by krok po kroku dojść do istoty sekwencjonowania.Sekwencjonowanie to jedna z najważniejszych technologii we współczesnej biologii molekularnej i nieocenione narzędzie w kryminalistyce.Zapraszają: Jan Czachorowski i Agata Małoburska
This episode of Absolute Gene-ius slithers into the surprising science of invasive species monitoring with Dr. Brian Bahder. A childhood love of bugs led Brian to a dynamic career in entomology and plant pathology—and eventually to tracking large reptiles in the swamps of Florida.We dive deep into Brian's work developing multiplex digital PCR assays to detect DNA from snakes, caimans, and other invasive species using environmental samples like soil and water. He explains how this technology enables detection even after the animals are gone, and how sampling strategy, environmental variables, and experimental design are critical to getting reliable data. He also compares qPCR and digital PCR, emphasizing how each has its place depending on sensitivity, speed, and sample complexity.In the career corner, Brian shares how his academic journey was shaped by travel, risk-taking, and a healthy dose of failure. From surfing and skateboarding to discovering new species and running a diagnostic clinic, his path reminds us that science thrives on curiosity—and that even mistakenly detecting your own DNA can teach you something.Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System.
⚠️ This is a slideshow, so I strongly recommend watching the video episode.Jamie Andrews and his colleagues have shown that viruses probably don't exist, or if they do, they're not what we believe them to be..The Substack The Virology Controls Studies Project by Jamie Andrews challenges virology and genetic science. It aims to prove virology is flawed through simple control experiments.His team's control studies are simple experiments designed to test virology's claims by comparing samples that should show a virus with ones that shouldn't.For example, they use cell cultures with and without supposed viral material to see if they behave differently, like showing cell damage (cytopathic effects). They also run PCR tests on samples with no virus to check if they still give false positives.The conclusion is that virologists' methods are unreliable because the results often look the same whether a virus is present or not.
[01:02:32:15 - 01:03:00:26] — New COVID Variant “Nimbus” EmergesA new COVID-19 strain named NB.1.8.1 or "Nimbus" is spreading across Europe, the Americas, and the Pacific. Despite its presence, public reaction remains muted, and the WHO has struggled to reignite pandemic-level fear.[01:03:02:19 - 01:04:06:05] — COVID Death Stats & PCR Test ManipulationThe segment critiques how COVID deaths were reported, alleging that deaths from unrelated causes were labeled as COVID due to unreliable PCR tests. The fear was manufactured, not the illness itself.[01:06:50:17 - 01:07:40:08] — Nimbus Is Mild, But Messaging ContinuesDespite its spread, the WHO and CDC state that the Nimbus variant causes no more severe illness than previous strains. Symptoms are flu-like, but official guidance still pushes boosters and ongoing monitoring.[01:11:16:16 - 01:13:05:21] — RFK Jr. Challenges CNN on Vaccine TrialsRFK Jr. rebuts CNN's claims that childhood vaccines underwent placebo-controlled trials. He asserts that none used inert placebos and criticizes the CDC's licensing process for lacking true scientific rigor.[01:14:05:06 - 01:14:30:08] — Rise in Childhood Vaccines Since 1986Kennedy highlights that routine childhood shots have risen from 11 in 1986 to as many as 92 today. He argues this dramatic increase has occurred without sufficient safety testing, driven by profits over protection.[01:17:58:11 - 01:18:34:20] — CNN's Vaccine Trial Evidence DeconstructedRFK Jr. dissects CNN's list of 257 studies, explaining that the majority used active or post-licensure comparators, not inert placebos. He says the data actually supports his claims about inadequate safety trials.[01:28:18:00 - 01:28:42:14] — Vaccines, Chronic Illness, and AccountabilityHe argues that the explosion in autoimmune and chronic conditions among children should force a reevaluation of the vaccine schedule, especially products designed to alter the immune system without proper testing.[01:33:02:03 - 01:33:52:06] — Polio Cases Fell Before Vaccine RolloutData suggests polio mortality declined significantly before the vaccine was introduced. Kennedy and sources argue the impact of vaccines is overstated and that case definitions were changed to exaggerate success.[01:37:39:03 - 01:38:52:10] — Gardasil and the Dangers of Active PlacebosThe HPV vaccine Gardasil is cited as an example where placebo-controlled trials were misleading, as toxic aluminum adjuvants were used instead of inert substances. 90% of test subjects had adverse reactions.[01:47:08:10 - 01:48:07:20] — Clots in Children of Vaccinated MothersA disturbing case is reported of fibrous clots found in a 3-year-old born to a vaccinated mother. Additional studies suggest reduced IVF success and raise red flags about long-term generational health effects. [01:50:22:15 - 01:51:05:27] — Medical Gaslighting of Vaccine-Injured ChildrenA mother describes how her child became severely ill after vaccination, only to be dismissed by doctors who diagnosed her daughter with a psychological condition. Despite visible symptoms, she was offered antidepressants instead of real treatment.[01:51:49:14 - 01:52:18:05] — Parents Silenced, Doctors in DenialAcross the country, parents of vaccine-injured children say they are routinely ignored or belittled by medical professionals. RFK Jr. calls it a systematic campaign of gaslighting, protecting pharma over patients.[01:52:18:07 - 01:53:02:24] — CDC Profits from the Vaccines It PromotesRFK Jr. exposes the CDC's deep financial entanglement with the pharmaceutical industry—owning patents and earning royalties on vaccines—creating an undeniable conflict of interest.[01:54:07:21 - 01:54:54:02] — Government Pharma Pipeline: Vaccines for ProfitThe CDC, FDA, and NIH hold patents on dozens of vaccines and directly profit from licensing deals. These regulatory agencies now act as business partners to Big Pharma while maintaining a public image of oversight.[01:55:33:03 - 01:56:30:05] — The Hippocratic Oath Is DeadRFK Jr. accuses the medical establishment of abandoning its ethical foundation. He says doctors today are more concerned with protecting institutions than protecting patients, calling modern medicine morally bankrupt.[01:57:31:19 - 01:58:30:17] — Alarming Trends: Fertility Drops & Infant ClotsData from IVF clinics and anecdotal reports point to falling fertility and potential reproductive harms post-vaccination. A disturbing case involves a baby born with fibrous clots—raising fears of generational damage.[01:59:58:27 - 02:01:16:17] — Censorship That Kills: The Price of Silencing DissentRFK Jr. argues that medical censorship during COVID wasn't just wrong—it was deadly. Early treatments were discredited, expert voices silenced, and lives were lost in the name of “consensus.”[02:01:30:00 - 02:02:14:00] — Gold, Silver, and the Crumbling Dollar (Tony Arterburn)Tony Arterburn gives an update on the precious metals market, warning of long-term dollar instability. He explains how gold and silver remain reliable hedges against inflation and financial collapse, especially in times of political and institutional distrust03:13:23:17 – 03:14:07:04 — ICE Raids Expand NationwideTrump deploys ICE tactical units to five Democrat-controlled cities, including New York and Seattle, as Los Angeles goes into lockdown due to immigration riots. The move intensifies the administration's aggressive immigration crackdown.03:14:17:18 – 03:14:49:11 — Newsom Warns of Federal OverreachCalifornia Governor Gavin Newsom delivers an emotional speech warning that Trump's unilateral deployment of the National Guard could set a dangerous precedent, applying to every state and threatening democratic norms.03:27:43:17 – 03:28:42:22 — Mexican Official Talks Reclaiming U.S. LandA Mexican senator suggests reclaiming U.S. territory lost after the Treaty of Guadalupe Hidalgo, showing a historical map and implying that migration could serve as a tool to reassert Mexico's claim over the American Southwest.Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
[01:02:32:15 - 01:03:00:26] — New COVID Variant “Nimbus” EmergesA new COVID-19 strain named NB.1.8.1 or "Nimbus" is spreading across Europe, the Americas, and the Pacific. Despite its presence, public reaction remains muted, and the WHO has struggled to reignite pandemic-level fear.[01:03:02:19 - 01:04:06:05] — COVID Death Stats & PCR Test ManipulationThe segment critiques how COVID deaths were reported, alleging that deaths from unrelated causes were labeled as COVID due to unreliable PCR tests. The fear was manufactured, not the illness itself.[01:06:50:17 - 01:07:40:08] — Nimbus Is Mild, But Messaging ContinuesDespite its spread, the WHO and CDC state that the Nimbus variant causes no more severe illness than previous strains. Symptoms are flu-like, but official guidance still pushes boosters and ongoing monitoring.[01:11:16:16 - 01:13:05:21] — RFK Jr. Challenges CNN on Vaccine TrialsRFK Jr. rebuts CNN's claims that childhood vaccines underwent placebo-controlled trials. He asserts that none used inert placebos and criticizes the CDC's licensing process for lacking true scientific rigor.[01:14:05:06 - 01:14:30:08] — Rise in Childhood Vaccines Since 1986Kennedy highlights that routine childhood shots have risen from 11 in 1986 to as many as 92 today. He argues this dramatic increase has occurred without sufficient safety testing, driven by profits over protection.[01:17:58:11 - 01:18:34:20] — CNN's Vaccine Trial Evidence DeconstructedRFK Jr. dissects CNN's list of 257 studies, explaining that the majority used active or post-licensure comparators, not inert placebos. He says the data actually supports his claims about inadequate safety trials.[01:28:18:00 - 01:28:42:14] — Vaccines, Chronic Illness, and AccountabilityHe argues that the explosion in autoimmune and chronic conditions among children should force a reevaluation of the vaccine schedule, especially products designed to alter the immune system without proper testing.[01:33:02:03 - 01:33:52:06] — Polio Cases Fell Before Vaccine RolloutData suggests polio mortality declined significantly before the vaccine was introduced. Kennedy and sources argue the impact of vaccines is overstated and that case definitions were changed to exaggerate success.[01:37:39:03 - 01:38:52:10] — Gardasil and the Dangers of Active PlacebosThe HPV vaccine Gardasil is cited as an example where placebo-controlled trials were misleading, as toxic aluminum adjuvants were used instead of inert substances. 90% of test subjects had adverse reactions.[01:47:08:10 - 01:48:07:20] — Clots in Children of Vaccinated MothersA disturbing case is reported of fibrous clots found in a 3-year-old born to a vaccinated mother. Additional studies suggest reduced IVF success and raise red flags about long-term generational health effects. [01:50:22:15 - 01:51:05:27] — Medical Gaslighting of Vaccine-Injured ChildrenA mother describes how her child became severely ill after vaccination, only to be dismissed by doctors who diagnosed her daughter with a psychological condition. Despite visible symptoms, she was offered antidepressants instead of real treatment.[01:51:49:14 - 01:52:18:05] — Parents Silenced, Doctors in DenialAcross the country, parents of vaccine-injured children say they are routinely ignored or belittled by medical professionals. RFK Jr. calls it a systematic campaign of gaslighting, protecting pharma over patients.[01:52:18:07 - 01:53:02:24] — CDC Profits from the Vaccines It PromotesRFK Jr. exposes the CDC's deep financial entanglement with the pharmaceutical industry—owning patents and earning royalties on vaccines—creating an undeniable conflict of interest.[01:54:07:21 - 01:54:54:02] — Government Pharma Pipeline: Vaccines for ProfitThe CDC, FDA, and NIH hold patents on dozens of vaccines and directly profit from licensing deals. These regulatory agencies now act as business partners to Big Pharma while maintaining a public image of oversight.[01:55:33:03 - 01:56:30:05] — The Hippocratic Oath Is DeadRFK Jr. accuses the medical establishment of abandoning its ethical foundation. He says doctors today are more concerned with protecting institutions than protecting patients, calling modern medicine morally bankrupt.[01:57:31:19 - 01:58:30:17] — Alarming Trends: Fertility Drops & Infant ClotsData from IVF clinics and anecdotal reports point to falling fertility and potential reproductive harms post-vaccination. A disturbing case involves a baby born with fibrous clots—raising fears of generational damage.[01:59:58:27 - 02:01:16:17] — Censorship That Kills: The Price of Silencing DissentRFK Jr. argues that medical censorship during COVID wasn't just wrong—it was deadly. Early treatments were discredited, expert voices silenced, and lives were lost in the name of “consensus.”[02:01:30:00 - 02:02:14:00] — Gold, Silver, and the Crumbling Dollar (Tony Arterburn)Tony Arterburn gives an update on the precious metals market, warning of long-term dollar instability. He explains how gold and silver remain reliable hedges against inflation and financial collapse, especially in times of political and institutional distrust03:13:23:17 – 03:14:07:04 — ICE Raids Expand NationwideTrump deploys ICE tactical units to five Democrat-controlled cities, including New York and Seattle, as Los Angeles goes into lockdown due to immigration riots. The move intensifies the administration's aggressive immigration crackdown.03:14:17:18 – 03:14:49:11 — Newsom Warns of Federal OverreachCalifornia Governor Gavin Newsom delivers an emotional speech warning that Trump's unilateral deployment of the National Guard could set a dangerous precedent, applying to every state and threatening democratic norms.03:27:43:17 – 03:28:42:22 — Mexican Official Talks Reclaiming U.S. LandA Mexican senator suggests reclaiming U.S. territory lost after the Treaty of Guadalupe Hidalgo, showing a historical map and implying that migration could serve as a tool to reassert Mexico's claim over the American Southwest.Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
In this podcast, I speak with Dr. Roger Hodkinson, a retired Pathologist in Alberta. Dr. Hodkinson was previously Assistant Professor in the faculty of medicine at the University of Alberta and President of the Alberta Society of Laboratory, Physicians. He is currently Chairman of a US biotechnology company that is developing a DNA-based diagnostic technology for STDs and respiratory infections. Dr. Hodkinson is well-known for his outspokenness during Covid and for his courage and honesty about the government overreach. He talks about how the whole Covid lie was propped up using the PCR test and reviews an exciting investment opportunity with his firm Multiseq, which has a definite test using advanced methods that will help stop the creation of "false positives" for any future "pandemics".
Send us a textScientific research at Yellowstone and other National Park has yielded many useful discoveries benefiting humanity. One of the most important was the discovery of the thermophilic bacterium, Thermus aquaticus. Later an enzyme was purified by a team led by Dr. Henry Erlich, which led to the practical use of the PCR test in covid detection and many other uses.Science in parks is a crucial tool for the advancement of humanity.However, if it were not for the early efforts of George Menendez Wright, science may have never taken hold in our national parks. Today, the George Wright Society continues that effort by supporting parks, protected/conserved areas, cultural sites, and other kinds of place-based conservation by encouraging communication among and convenings of researchers, managers, educators, practitioners, and the public to facilitate informed decisions and actions that embrace our values.Joining me to talk science in our national parks is Dave Harmon, executive director of the George Wright Society. Dave is responsible for overseeing the George Wright Society's operations, including co-editing Parks Stewardship Forum and helping plan workshops and other meetings. A member of the GWS since 1985, Dave began working for the organization in 1990 and served as executive director from 1998 to 2017 before returning that role in 2019. He is active in IUCN's World Commission on Protected Areas. He also maintains a research interest in the relationship between biological and cultural diversity, having co-founded the NGO Terralingua, which is devoted to that subject. Dave has co-edited several volumes on protected area conservation, including The Antiquities Act: A Century of American Archaeology, Historic Preservation, and Nature Conservation (with Francis P. McManamon and Dwight T. Pitcaithley), The Full Value of Parks: From Economics to the Intangible (with Allen D. Putney), and A Thinking Person's Guide to America's National Parks (with Robert Manning, Rolf Diamant, and Nora Mitchell).https:/natureandsciencepodcast.com
Hello and welcome to Entangled! The podcast where we explore the science of consciousness, the true nature of reality, and what it means to be a spiritual being having a human experience.I'm your host Jordan Youkilis, and today I'm joined by my friend Dr. Peter Petropulos, founder of Rejuvenate Wellness Center. In this episode, Dr. P details his career, from joining the Navy as a Medical Corpsman, moving into the medical school path, and ultimately focusing on traditional medicine, where he earned his Doctor of Chiropractic and started his own practice.Peter and I discuss the distinguishing characteristics of alternative / traditional medicine relative to western medicine, and how the Rockefellers changed the paradigm of modern medicine to focus on petrochemical, pharmaceutical based interventions. We then discuss problems associated with GMOs, pesticides, and forever chemicals, and the connections between Big Ag and Big Chemical.Next, we discuss the cost benefit analysis conducted by “leaders” of Big Pharma, and their callous decisions to roll out new medicines if their expected drug profits exceed expected litigation payouts. Dr. Petropulos explains why we need to make vaccine manufacturers liable again, after the disastrous decision in 1986 to pass the National Vaccine Childhood Injury Act.From there, we discuss the impact of DDT on paralytic disease, and the connection between the elimination of DDT and the reduction in polio. We consider vaccine orthodoxy, and why people are so afraid to question it, especially as it relates to autism.Dr. Petropulos explains why orthodoxy precludes us from looking for the real etiology of diseases and for real treatments. We ask why safe and efficacious treatments like ivermectin and hydroxychloroquine were suppressed during the pandemic, but deadly, dangerous interventions like remdesivir, molnupiravir, and ventilators were promoted.Next, we discuss the ruling elites' ties to Malthusian ideology, eugenics, and depopulation. Peter explains the process of virus isolation and genomic consensus, and why these are presumptive and speculative. We consider Dr. Fauci's long history of criminality, including during the AIDS epidemic, and the curious fact that Burroughs Wellcome manufactures both “poppers” and AZT.We then discuss the failures of PCR tests, and why its inventor, Dr. Kary Mullis, has been such a staunch opponent of Fauci for decades. We consider the correlation of flu epidemics and solar maximums, and the deregulating impact of electromagnetic frequency. We then discuss the fear propaganda pumped by the establishment, and the impact of weather manipulation on EMF stressors.From there, Dr. P explains how he has been involved with vaccine safety for decades, and how that connected him to Robert F. Kennedy, Jr. and Children's Health Defense. We consider how the media has been able to enforce vaccine orthodoxy. Dr. Petropulos explains his main hopes for Secretary Kennedy's HHS, including eliminating pharmaceutical advertising, removing indemnity from vaccine manufacturers, and ending the funding of medical schools by criminal NGOs.We then discuss the need for COVID-19 pandemic accountability, and our hopes that Attorney General Pam Bondi will bring justice to the biggest perpetrators of the Plandemic fraud, including Tony Fauci, George Soros and Bill Gates. We then consider the revolution of media and the high caliber of content being produced today. Dr. Petropulos explains how he came around to the MAGA MAHA Alliance, and why President Trump needs to take ownership for the failures of Operation Warp Speed.We then discuss the release of the Epstein files and his connections to intelligence, organized crime, and the elitist class. We consider the use of sexual blackmail as a tool of control and its insidious ties to the occult. We ask what the future has in store for the oligarchy, and discuss why the central bankers need to be held accountable for their crimes against humanity.Peter and I then discuss political reform at the state and local level, the future of the Democratic party, and how to end the polarization of politics. Dr. P describes the expansion of Children's Health Defense to Colorado, the spread of information related to vaccine injuries, and the increase in sudden deaths following the COVID “vaccination” program.Dr. P describes the importance of shifting off a mandatory vaccine schedule and the ethical necessity of informed consent. We conclude the conversation highlighting COVID-19 as a moment of awakening for the general public and for influential members of the scientific community.This outro is titled: “Vaxxed & Unafraid”. Music from the show is available on the Spotify playlist “Entangled – The Vibes”. If you like the show, please drop a 5-star review and subscribe on Substack, Spotify, X, Apple or wherever you listen to podcasts.Please enjoy the episode!Music: Intro: Ben Fox - "The Vibe". End Credits: Maya Pacziga – “Healing”.Outro: “Vaxxed & Unafraid” starts at 1:30:00.Recorded: 02/14/25. Published: 06/03/25.Check out the resources mentioned:* Rejuvenate Wellness Center: https://www.rejuvenatewellnesscenter.com/* The AIDS War: Propaganda, Profiteering, and Genocide from the Medical Industrial Complex by John Lauritsen: https://a.co/d/fEJLqKm* A Farewell to Virology by Dr. Mark Bailey: https://a.co/d/flpVbTr* Virus Mania: How the Medical Industry Continually Invents Epidemics, Making Billion-Dollar Profits At Our Expense by Torsten Engelbrecht and Claus Kohnlein: https://a.co/d/cf52SOG* The Truth About Contagion: Exploring Theories of How Disease Spreads by Dr. Thomas Cowan and Saly Fallon Morell: https://a.co/d/bi37Phj* Inventing the AIDS Virus by Peter Duesberg: https://a.co/d/8hPUgCh This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit entangledpodcast.substack.com
What happens when allergen contamination starts at the farm—and no one saw it coming?In this powerful episode of our Allergen Podcast Series, Jatin Patel from FGS Ingredients shares the real story behind a nationwide recall involving mustard contaminated with peanut traces. Hosted by Alan Cadman of Intertek Food Services UK, the discussion explores:Inconsistent lab results (PCR vs ELISA)The operational impact of unexpected recallsSteps to protect consumers from unknown risks
In this Mol Bio Minutes episode, Laurynas Alijošius breaks down how to run fast PCR to save time and increase lab efficiency. He explains how to choose the right thermal cycler with fast ramp speeds, select low-volume and thin-walled PCR plastics, and use engineered DNA polymerases that offer rapid elongation and hot-start capability. Laurynas also covers practical tips for optimizing reaction components, shortening cycling protocols, and reducing waste. Whether you're aiming to finish your experiment before dinner or streamline your workflow long-term, this episode delivers everything you need to master the art of fast PCR.Helpful resource links mentioned in this episode:Molecular biology handbook – An extensive resource for all things molecular biologyApplied Biosystems thermal cyclers – Including those that support fast PCRPCR consumables – Four key attributes to considerPCR plastics selection tool – Find the right plastics for your instrument and fast PCRDNA polymerases – Four key characteristics to know and considerPCR setup optimization – Six critical things to optimize for optimal PCR resultsEnzymes and master mixes – Get the right reagents to drive your PCR reactionCycling optimization – Instrument considerations for PCR success Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague. Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.
00:02:32 - 00:06:30: Critique of Trump's “Big Beautiful Bill” - Analyzes Trump's bill, which increases national debt by $3.3 trillion, includes tax cuts like no taxes on tips, but prioritizes military spending over real cuts. Highlights Ron Paul's call to reduce military-industrial complex expenditure. 00:26:15 - 00:31:52: Central Bank Digital Currencies (CBDCs) and Control - Discusses globalist agenda for CBDCs, quoting Augustine Carstens on centralized control and transaction tracking, warning of threats to personal freedom and privacy. 01:02:12 - 01:09:32: AI Manipulation on Social Media - Covers University of Zurich experiment where AI bots on Reddit manipulated users' beliefs through lies and targeted vulnerabilities, raising ethical concerns about AI-driven propaganda. 01:16:52 - 01:17:33: Show Introduction and Music Appreciation - Welcomes listeners back to the David Knight Show, acknowledges a viewer's comment praising David's music for breaks, and mentions a potential relaxed evening stream. 01:18:26 - 01:25:12: Pastor on Angels and Demons - Pastor Alan Jackson discusses his book Angels, Demons and You, emphasizing the reality of spiritual forces, their role in the gospel, and the church's disconnect from these truths due to rationalism and a diluted gospel. 01:25:42 - 01:35:35: Pagan Indoctrination in Schools - Reports on Chicago schools forcing Hindu rituals on students via the David Lynch Foundation, leading to a $2.6M settlement. Highlights broader pagan indoctrination (Hinduism, Buddhism, Islam) in U.S. public schools, rooted in anti-Christian agendas. 01:44:40 - 01:51:48: COVID Death Misinformation - Critiques ABC News' claim of 300+ weekly U.S. COVID deaths, alleging manipulated data (PCR tests, misattributed causes) and fearmongering to push vaccines, despite low uptake and known risks. 01:51:48 - 01:58:44: Vaccine Harms and Misreporting - Discusses adverse effects of COVID vaccines (e.g., renal failure), underreporting in VAERS, and the dangers of live virus vaccines, supported by audience comments from a paramedic and others. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
00:02:32 - 00:06:30: Critique of Trump's “Big Beautiful Bill” - Analyzes Trump's bill, which increases national debt by $3.3 trillion, includes tax cuts like no taxes on tips, but prioritizes military spending over real cuts. Highlights Ron Paul's call to reduce military-industrial complex expenditure. 00:26:15 - 00:31:52: Central Bank Digital Currencies (CBDCs) and Control - Discusses globalist agenda for CBDCs, quoting Augustine Carstens on centralized control and transaction tracking, warning of threats to personal freedom and privacy. 01:02:12 - 01:09:32: AI Manipulation on Social Media - Covers University of Zurich experiment where AI bots on Reddit manipulated users' beliefs through lies and targeted vulnerabilities, raising ethical concerns about AI-driven propaganda. 01:16:52 - 01:17:33: Show Introduction and Music Appreciation - Welcomes listeners back to the David Knight Show, acknowledges a viewer's comment praising David's music for breaks, and mentions a potential relaxed evening stream. 01:18:26 - 01:25:12: Pastor on Angels and Demons - Pastor Alan Jackson discusses his book Angels, Demons and You, emphasizing the reality of spiritual forces, their role in the gospel, and the church's disconnect from these truths due to rationalism and a diluted gospel. 01:25:42 - 01:35:35: Pagan Indoctrination in Schools - Reports on Chicago schools forcing Hindu rituals on students via the David Lynch Foundation, leading to a $2.6M settlement. Highlights broader pagan indoctrination (Hinduism, Buddhism, Islam) in U.S. public schools, rooted in anti-Christian agendas. 01:44:40 - 01:51:48: COVID Death Misinformation - Critiques ABC News' claim of 300+ weekly U.S. COVID deaths, alleging manipulated data (PCR tests, misattributed causes) and fearmongering to push vaccines, despite low uptake and known risks. 01:51:48 - 01:58:44: Vaccine Harms and Misreporting - Discusses adverse effects of COVID vaccines (e.g., renal failure), underreporting in VAERS, and the dangers of live virus vaccines, supported by audience comments from a paramedic and others. Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
Fresh off Spring Break DJ Boss Player and the Mori Show came to give you the special podcast flavor you love. Peep it!
DJ Boss Player and the Mori Show aka Sugar Plug are just poddin' giving y'all vibez from the stratosphere!
Boss Playa from the Himalayas and The Mori Show kick it for your listening pleasure!
What's good? DJ Boss Player and the Mori Show aka Sugar Plug were coolin on the set waxing philosophical. Pull up a chair, have a seat and join us!
The revolution will not be televised, but's live on your radio right now! Shoutout to the Pop Culture Revolutionaries! Check out this week's vibez with DJ Boss Player and The Mori Show!
DJ Boss Player and The Mori Show aka Sugar Plug were waxing nostalgic for their last show at WMUC! Shoutout to all the former Hip-Hop Corner show and Pop Culture Revolution cohosts! We're on to bigger and better things! Stay tuned!
DITCH YOUR DOCTOR! https://www.livelongerformula.com/wam Get a natural health practitioner and work with Christian Yordanov! Mention WAM and get a FREE masterclass! You will ALSO get a FREE metabolic function assessment! HELP SUPPORT US AS WE DOCUMENT HISTORY HERE: https://gogetfunding.com/help-wam-cover-history/ GET NON-MRNA FREEZE DRIED MEAT HERE: https://wambeef.com/ Use code WAMBEEF to save 20%! GET HEIRLOOM SEEDS & NON GMO SURVIVAL FOOD HERE: https://heavensharvest.com/ USE Code WAM to save 5% plus free shipping! GET YOUR APRICOT SEEDS at the life-saving Richardson Nutritional Center HERE: https://rncstore.com/r?id=bg8qc1 Use code JOSH to save money! Josh Sigurdson reports on the psyop that is the MAHA movement which, although it's great to see things we've been talking about for decades come to light in the mainstream, the movement continues to push limited hangout distractions and disappoint millions. RFK Jr. who essentially leads the MAHA movement under President (Operation WARP Speed) Donald Trump has recently called for people to inject their children with the Measles MMR vaccine despite years of calling out the dangers of it. While there appears to be some positive changes happening by the Department of Health and Human Services and the FDA, much of it remains a distraction. Recently, the FDA announced there will be stronger warnings added to Pfizer and Moderna Covid "vaccines" regarding possible heart damage. The FDA is also going to mandate warnings by doctors to people 65 and older and "high risk groups" regarding possible heart damage by Covid shots. This is despite young people having the highest risk. Is this the "justice" people have been asking for? What happened to Fauci going to jail? What happened to a ban on covid injections? It's still mandated as part of the schedule for babies which RFK has said he won't be touching. Do people not see what's happening here? Then people get distracted and move on to the next thing like they did with Epstein and JFK. Meanwhile the FDA is fast tracking the self amplifying mRNA Bird Flu vaccine which will create a vector of perpetual gene editing within your body over the next hoax which RFK Jr. claims he's "taking seriously." RFK was confirmed by a pharma funded house. Don't forget that. He also appears to be dramatically compromised with his connections with Rabbi Shmuley among others. Trump signed an order against price gouging big pharma corporations but that does essentially nothing considering the massive constantly growing subsidization pharma gets from countries like the UK and Canada. Besides, how is it "MAHA" to want MORE pharmaceutical drugs? The UK government is PCR testing tens of thousands of mosquitoes. Russia is warning of a "cat flu." They're planning something big. Everyone will be sitting on their hands as the World Health Organization (WHO) has already pushed forward their Pandemic Treaty. While Trump pulled out of the WHO, it takes years to complete this process and the emergency orders may happen anyways considering the US is also signed on to the United Nations' Pact For The Future which includes forced rations, injections, carbon credits and bank closures. They will stop at nothing to bring in the technocratic digital ID system and the Mainstream Alternative Media alongside the Mainstream Media will sit there and tell you nothing about it. There are pandemic exercises taking place right now and most are simply sitting apathetic, sitting on their hands, waiting for the government to fix the problems of the government for the dependent masses. You must remove YOURSELF from the system to solve the problems of the system. Prepare yourselves. Stay tuned for more from WAM! Get local, healthy, pasture raised meat delivered to your door here: https://wildpastures.com/promos/save-20-for-life/bonus15?oid=6&affid=321 USE THE LINK & get 20% off for life and $15 off your first box! SIGN UP FOR HOMESTEADING COURSES NOW: https://freedomfarmers.com/link/17150/ Get Prepared & Start The Move Towards Real Independence With Curtis Stone's Courses! GET ORGANIC CHAGA MUSHROOMS HERE: https://alaskachaga.com/wam Use code WAM to save money! See shop for a wide range of products! BUY GOLD HERE: https://firstnationalbullion.com/schedule-consult/ PayPal: ancientwonderstelevision@gmail.com FIND OUR CoinTree page here: https://cointr.ee/joshsigurdson JOIN US on SubscribeStar here: https://www.subscribestar.com/world-alternative-media For subscriber only content! Pledge here! Just a dollar a month can help us alive! https://www.patreon.com/user?u=2652072&ty=h&u=2652072 BITCOIN ADDRESS: 18d1WEnYYhBRgZVbeyLr6UfiJhrQygcgNU World Alternative Media 2025
Dr. John Sweetenham and Dr. Erika Hamilton discuss top abstracts that will be presented at the 2025 ASCO Annual Meeting, including research on tech innovations that could shape the future of oncology. Transcript Dr. John Sweetenham: Hello, and welcome to the ASCO Daily News Podcast. I'm your host, Dr. John Sweetenham, and I'm delighted to be joined today by Dr. Erika Hamilton, a medical oncologist and director of breast cancer and gynecologic cancer research at the Sarah Cannon Research Institute in Nashville, Tennessee. Dr. Hamilton is also the chair of the 2025 ASCO Annual Meeting Scientific Program, and she's here to tell us about some of the key abstracts, hot topics, and novel approaches in cancer care that will be featured at this year's Annual Meeting. Our full disclosures are available in the transcript of this episode. Dr. Hamilton, it's great to have you on the podcast today, and thanks so much for being here. Dr. Erika Hamilton: Thanks, Dr. Sweetenham. I'm glad to be here. Dr. John Sweetenham: Dr. Hamilton, the Presidential Theme of the Annual Meeting this year is ‘Driving Knowledge to Action: Building a Better Future,' and that's reflected in many of the sessions that will focus on action-oriented guidance to improve care for our patients. And as always, there'll be great presentations on practice-changing abstracts that will change treatment paradigms and transform care. Can you tell us about some of the hot topics this year and what you're particularly excited about? Dr. Erika Hamilton: You're right. Dr. Robin Zon's theme is ‘Driving Knowledge to Action: Building a Better Future,' and you're going to see that theme really interlaced throughout the ASCO program this year. We had a record number of submissions. Over 5,000 abstracts will be published, and there'll be about 3,000 presentations, either in oral format or poster presentations. We have 200 dynamic sessions. Many of the discussants will be highlighting key takeaways and how we can translate action-oriented guidance to better treat our patients to build a better future. Our state-of-the-art science will include a Plenary Session. This will feature presentations as well as discussion of each of the presentations for clinical late-breaking abstracts. We have Clinical Science Symposia that I'm particularly excited about this year. These will feature key abstracts as well as discussions and a foundational talk around the subject. We're covering novel antibody-drug conjugate targets, turning “cold” tumors “hot” to include CAR T, as well as the future of cancer detection. There'll be rapid oral abstracts, case-based panels, and this will also feature interactive audience polling and case discussions. I also want to highlight the community connection opportunities. There will be 13 Communities of Practice that will be meeting on-site during ASCO, and there's also really a plethora of networking opportunities for trainees and early-career professionals, a Women's Networking Center, a patient advocate space, and I'm happy to report there will also be live music out on the terrace this year at ASCO. Dr. John Sweetenham: Well, that's going to be a really great addition. I have to say, I think this is always a special time of year because excitement starts to mount as the meeting gets closer and closer. And once the abstracts are out there, I certainly personally feel that the excitement builds. Talking of abstracts, let's dive into some of the key abstracts for this year's meeting. I'd like to start out by asking you about Abstract 505. This reports on 15-year outcomes for women with premenopausal hormone receptor-positive early breast cancer in the SOFT and TEXT trials. It assesses the benefits of adjuvant exemestane and ovarian function suppression or tamoxifen and ovarian function suppression. So, could you talk us through this and tell us what you think the key takeaways from this abstract are? Dr. Erika Hamilton: Absolutely. This is essentially the SOFT and TEXT trials. They are trials that we've been following for quite some time, evidenced by the 15-year outcome. And I think it really answers two very important questions for us regarding adjuvant endocrine therapy for patients that are facing hormone receptor-positive disease. The benefit of ovarian function suppression for one, and then second, the benefit of exemestane over tamoxifen, which is our SERM [selective estrogen receptor modulator]. So, in terms of the SOFT trial, when we talk about distance recurrence-free interval, which I really think is probably the most meaningful because secondary cancers, et cetera, are not really what we're getting at here. But in terms of distant recurrence-free interval, certainly with tamoxifen, using tamoxifen plus ovarian function suppression adds a little bit. But where we really get additional benefits are by moving to exemestane, an aromatase inhibitor with the ovarian function suppression. So, for example, in SOFT, for distant recurrence-free interval for patients that have received prior chemotherapy, the distance recurrence-free interval was 73.5% with tamoxifen, bumped up just a tiny bit to 73.8% with ovarian function suppression. But when we used both ovarian function suppression and switched to that aromatase inhibitor, we're now talking about 77.6%. It may seem like these are small numbers, but when we talk about an absolute benefit of 4%, these are the type of decisions that we decide whether to offer chemotherapy based on. So, really just optimizing endocrine therapy really can provide additional benefits for these patients. Just briefly, when we turn to TEXT, similarly, when we look at distance recurrence-free interval for our patients that are at highest risk and receive chemotherapy, tamoxifen and ovarian function suppression, 79%; 81% with exemestane and ovarian function suppression. And when we talk about our patients that did not receive chemotherapy, it increased from 91.6% up to 94.6%—very similar that 3% to 4% number. So, I think that this is just very important information when counseling our patients about the decisions that they're going to make for themselves in the adjuvant setting and how much we want to optimize endocrine therapy. Dr. John Sweetenham: Thanks so much for your insight into that. Dr. Erika Hamilton: Yeah, absolutely. So, let's turn to hematologic malignancies. Abstract 6506 reports exciting results on the new agent ziftomenib in relapsed/refractory NPM1-mutant acute myeloid leukemia. This is a phase 1b clinical activity study and safety results. This was the pivotal KOMET-001 study. And my question is, will this new agent fulfill an unmet need in this NPM1 space? Dr. John Sweetenham: Yeah, great question. And I think the answer is almost certainly ‘yes'. So, just as some brief background, NPM1 mutation is known to be a driver of leukemogenesis in around 30% of patients with AML, and it's a poor prognostic factor. And typically, about 50% of these patients will relapse within a year of their first-line therapy, and only around 10% of them will get a subsequent complete remission with salvage therapy. Menin inhibitors, which disrupt the interaction between menin and KMT2A, are known to be active in NPM1-mutated as well as in KMT2A-rearranged AML. And ziftomenib is a selective oral menin inhibitor, which in this study was evaluated at a dose of 600 mg once a day, as you mentioned, a phase 1b/2 study, which is multicenter and presented by Dr. Eunice Wang from Roswell Park. It's a relatively large study of 112 patients who were treated with this standard dose with relatively short median follow-up at this time. The median age was 69 years, and median prior therapies were two, but with a range of one to seven. And I think very importantly, 60% of these patients had previously been treated with venetoclax, and 23% of them had had a prior transplant. Looking at the results overall for this study, the overall response rate was 35%, which is actually quite impressive. Specifically for those patients in the phase 2 part of the study, around 23% achieved a CR [complete remission] or CRh [complete remission with partial hematologic recovery]. What's very interesting in my mind is that the response rates were comparable in venetoclax-naive and venetoclax-exposed patients. And the drug was very well tolerated, with only 3% of patients having to discontinue because of treatment-related adverse events. And I think the authors appropriately conclude that, first of all, the phase 2 primary endpoint in the study was met, and that ziftomenib achieved deep and durable responses in relapsed and refractory NPM1-mutated AML, regardless of prior venetoclax, with good tolerance of the drug. And so, I think putting all of this together, undoubtedly, these data do support the potential use of this agent as monotherapy and as a new option for those patients who have relapsed or refractory NPM1-mutated acute myeloid leukemia. So, let's move on a little bit more now and change the subject and change gears completely and talk about circulating tumor DNA [ctDNA]. This has been a hot topic over a number of years now, and at this year's meeting, there are quite a few impactful studies on the use of ctDNA. We have time to focus on just one of these, and I wanted to get your thoughts on Abstract 4503. This is from the NIAGARA trial, which looks at ctDNA in patients with muscle-invasive bladder cancer who receive perioperative durvalumab. Could you tell us a little bit about this study? Dr. Erika Hamilton: So, this was the phase 3 NIAGARA trial, and this is literally looking for patients with muscle-invasive bladder cancer that are cisplatin-eligible, and the addition of durvalumab to neoadjuvant chemotherapy. So here, this is a planned exploratory analysis of ctDNA and the association with clinical outcomes from NIAGARA. So, this is really the type of study that helps us determine which of our patients are more likely to have a good outcome and which of our patients are more likely not to. There were 1,000 randomized patients in this study, and 462 comprised the biomarker-evaluable population. There were about half in the control arm and half in the durvalumab arm. And overall, the ctDNA-positive rate at baseline was about 57%, or a little over half, and that had decreased to about 22% after neoadjuvant treatment. ctDNA clearance rates from baseline to pre-radical cystectomy was about 41% among those with durvalumab and 31% among those in control. And the non-pCR rate was 97% among patients with pre-cystectomy ctDNA-positive status. So, this really gives us some information about predicting who is going to have better outcomes here. We did see a disease-free survival benefit with perioperative durvalumab, and this was observed in post-cystectomy ctDNA-positive as well as the ctDNA-negative groups. Shifting gears now to GI cancer, Abstract 3506 is a long-term safety and efficacy study of sotorasib plus panitumumab and FOLFIRI for previously treated KRAS G12C-mutated metastatic colorectal cancer. And this is the CodeBreaK-101 study. What are your thoughts on this study? Dr. John Sweetenham: Yeah, thanks. A very interesting study, and this abstract builds upon the phase 3 CodeBreaK-300 trial, which I think has just been published in the Journal of Clinical Oncology. This showed that the combination of sotorasib and panitumumab improved clinical outcomes in patients with chemorefractory KRAS G12C-mutated metastatic colorectal cancer. The current abstract, as you mentioned, reports the CodeBreaK-101 trial. And this was a phase 1b trial where FOLFIRI therapy was added to sotorasib and panitumumab in previously treated patients with KRAS G12C-mutated metastatic colorectal cancer. The abstract reports the overall and progression-free survival results, as well as some updated safety and response data. So, in this study, patients with this particular mutation who had received at least one prior systemic treatment but were KRAS G12C inhibitor-naive were enrolled into an expansion cohort of the CodeBreaK-101 protocol. And these patients received what apparently now recommended as the standard phase 2 dose of sotorasib of 960 mg daily, plus panitumumab and a standard dose of FOLFIRI. And the primary endpoint of the study was safety, and secondary endpoints included confirmed response, overall response, and progression-free survival, as assessed by the investigator. And by November of last year, 40 patients had been enrolled into this study. Common treatment-related adverse events were cutaneous; some patients developed neutropenia, and stomatitis was fairly widespread. Discontinuation of sotorasib because of adverse events was only seen in 1% of patients, although patients did have to discontinue because of toxicity from some of the other agents in the combination. Looking at the results of this study, the updated objective response rate was 57.5%, and the disease control rate was estimated at 92%, going on 93%, with a median time to response of 1.6 months and a median response duration of 6 months. After a median follow-up of 29.2 months, the median progression-free survival was 8.2 months, and the overall survival 17.9 months. So, the authors have concluded that this combination, including sotorasib, panitumumab, and FOLFIRI, does appear to show quite promising long-term efficacy in pretreated patients with this specific mutation. The ongoing phase 3 study they mentioned, CodeBreaK-301, is aiming to evaluate this combination against the standard of care in the first-line setting for patients with KRAS G12C-mutated colorectal cancer. So, promising results, and we'd be very interested to see how this particular combination performs in the frontline. Dr. Erika Hamilton: Fantastic. Thanks so much for sharing that. Let's shift gears again and really talk about digital technology. I feel that we're all going to have to get much better with this, and really, there are a lot of promises for our patients coming here. There are a lot of abstracts at ASCO that are focusing on innovations in digital technology, including a really interesting psychosocial digital application for caregivers of patients that are undergoing hematopoietic stem cell transplantation. Can you tell us a little bit about this? It's Abstract 11000. Dr. John Sweetenham: Yeah, absolutely. This abstract certainly caught my eye, and I think it's intriguing for a number of reasons, partly because it's app-based, and partly also because it specifically addresses caregiver burden and caregiver needs in the oncology setting, which I think is especially important. And although the context, the clinical context of this study, is hematopoietic stem cell transplantation, I think it has potential applications way beyond that. We all know that caregivers of patients undergoing stem cell transplantation have significant quality-of-life struggles. They are well-documented to have significant psychological and emotional strain before, during, and after stem cell transplantation. And this abstract describes an application called BMT-CARE, which is aimed at improving caregivers' quality of life, caregiver burden, mood symptoms, and coping skills, and so on. So, this was a single-center, randomized trial from MGH [Massachusetts General Hospital] of this app for stem cell transplant caregivers, compared with usual care in those individuals. And the eligible patients, or eligible individuals, were adults caring for patients with heme malignancy undergoing either an autologous or an allogeneic stem cell transplant. Patients were randomly assigned either to use the app or for usual care. And the app itself—and I think it'll be interesting to actually see this at the meeting and visualize it and see how user-friendly and so on it is—but it comprises five modules, which integrate psychoeducation, behavior change, stress management, and they're delivered through a kind of interactive platform of educational games and videos. And then participants were self-reporting at baseline and then 60 days after transplant. So, around 125 patients were enrolled in this study, of around 174 who were initially approached. So, just over 70% uptake from caregivers, which is, I think, relatively high, and evenly distributed between the two randomized arms. And the majority of the participants were spouses. And at 60 days post-stem cell transplant, the intervention participants reported a better quality of life compared with those who received usual care. If you break this down a little bit more, these participants reported lower caregiving burden, lower incidence of depression, fewer PTSD symptoms, and overall better coping skills. So, the authors conclude that this particular app, a digital health intervention, led to pretty substantial improvements in quality of life for these caregivers. So, intriguing. As I said, it'll be particularly interesting to see how this thing looks during the meeting. But if these kind of results can be reproduced, I think this sort of application has potential uses way beyond the stem cell transplant setting. Dr. Erika Hamilton: Yeah, I find that just so fascinating and very needed. I think that the caregiving role is often underestimated in how important that is for the patient and the whole family, and really giving our caregivers more tools in their toolbox certainly is quite helpful. Dr. John Sweetenham: Absolutely. Well, the meeting is getting closer, and as I mentioned earlier, I think anticipation is mounting. And I wanted to say thanks so much to you for chatting with me today about some of the interesting advances in oncology that we're going to see at this year's meeting. There is a great deal more to come. Our listeners can access links to the studies we've discussed today in the transcript of this episode. I'm also looking forward, Dr. Hamilton, to having you back on the podcast after the Annual Meeting to dive into some of the late-breaking abstracts and some of the other key science that's captured the headlines this year. So, thanks once again for joining me today. Dr. Erika Hamilton: Thanks so much for having me. Pleasure. Dr. John Sweetenham: And thank you to our listeners for joining us today. Be sure to catch my “Top Takeaways from ASCO25.” These are short episodes that will drop each day of the meeting at 5:30 p.m. Eastern Time. So, subscribe to the ASCO Daily News Podcast wherever you prefer to listen, and join me for concise analyses of the meeting's key abstracts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. More on today's speakers: Dr. John Sweetenham Dr. Erika Hamilton @erikahamilton9 Follow ASCO on social media: @ASCO on Twitter ASCO on Bluesky ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. John Sweetenham: No relationships to disclose Dr. Erika Hamilton: Consulting or Advisory Role (Inst): Pfizer, Genentech/Roche, Lilly, Daiichi Sankyo, Mersana, AstraZeneca, Novartis, Ellipses Pharma, Olema Pharmaceuticals, Stemline Therapeutics, Tubulis, Verascity Science, Theratechnologies, Accutar Biotechnology, Entos, Fosun Pharma, Gilead Sciences, Jazz Pharmaceuticals, Medical Pharma Services, Hosun Pharma, Zentalis Pharmaceuticals, Jefferies, Tempus Labs, Arvinas, Circle Pharma, Janssen, Johnson and Johnson Research Funding (Inst): AstraZeneca, Hutchison MediPharma, OncoMed, MedImmune, Stem CentRx, Genentech/Roche, Curis, Verastem, Zymeworks, Syndax, Lycera, Rgenix, Novartis, Millenium, TapImmune, Inc., Lilly, Pfizer, Lilly, Pfizer, Tesaro, Boehringer Ingelheim, H3 Biomedicine, Radius Health, Acerta Pharma, Macrogenics, Abbvie, Immunomedics, Fujifilm, eFFECTOR Therapeutics, Merus, Nucana, Regeneron, Leap Therapeutics, Taiho Pharmaceuticals, EMD Serono, Daiichi Sankyo, ArQule, Syros Pharmaceuticals, Clovis Oncology, CytomX Therapeutics, InventisBio, Deciphera, Sermonix Pharmaceuticals, Zenith Epigentics, Arvinas, Harpoon, Black Diamond, Orinove, Molecular Templates, Seattle Genetics, Compugen, GI Therapeutics, Karyopharm Therapeutics, Dana-Farber Cancer Hospital, Shattuck Labs, PharmaMar, Olema Pharmaceuticals, Immunogen, Plexxikon, Amgen, Akesobio Australia, ADC Therapeutics, AtlasMedx, Aravive, Ellipses Pharma, Incyte, MabSpace Biosciences, ORIC Pharmaceuticals, Pieris Pharmaceuticals, Pieris Pharmaceuticals, Pionyr, Repetoire Immune Medicines, Treadwell Therapeutics, Accutar Biotech, Artios, Bliss Biopharmaceutical, Cascadian Therapeutics, Dantari, Duality Biologics, Elucida Oncology, Infinity Pharmaceuticals, Relay Therapeutics, Tolmar, Torque, BeiGene, Context Therapeutics, K-Group Beta, Kind Pharmaceuticals, Loxo Oncology, Oncothyreon, Orum Therapeutics, Prelude Therapeutics, Profound Bio, Cullinan Oncology, Bristol-Myers Squib, Eisai, Fochon Pharmaceuticals, Gilead Sciences, Inspirna, Myriad Genetics, Silverback Therapeutics, Stemline Therapeutics
Ever thought about why medications work differently for different people? In this episode of Absolute Gene-ius, we explore the exciting field of pharmacogenomics with Wendy Wang, pharmacogenetic laboratory supervisor at Children's Mercy Hospital in Kansas City. Wendy shares how genetics can influence drug metabolism, offering a glimpse into how precision medicine can revolutionize healthcare by tailoring treatments based on an individual's unique genetic makeup.At the heart of Wendy's research is CYP2D6, a cytochrome P450 enzyme responsible for metabolizing around 20% of all prescribed medications. She explains how her lab uses digital PCR to analyze copy number variations (CNV), offering a reliable and precise method to predict drug metabolism. Wendy dives into the complexities of structural variants, the role of digital PCR in enhancing assay efficiency, and why pharmacogenomics is a critical piece of the precision medicine puzzle. Her use of delightful metaphors—like comparing genetic testing to ladling soup—makes complex science both relatable and engaging.In the Career Corner, Wendy opens up about her winding path to molecular biology, which included studying classical antiquity and nearly pursuing a career in history. She emphasizes the importance of resilience in research, embracing failure as a learning opportunity, and encourages budding scientists to reach out to mentors and explore diverse interests. Plus, hear about her most embarrassing lab mishap (hint: it involves a fire alarm) and the proud moment of publishing her first, first-author paper.Visit the Absolute Gene-ius page to learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System.
From the archives: 6-21-23Touch DNA refers to the trace amounts of DNA that can be transferred through direct contact between an individual's skin cells and an object or surface. It is a valuable forensic tool used in crime scene investigations to help identify potential suspects or link individuals to a particular location.When individuals touch an object or surface, they leave behind skin cells containing their DNA. Touch DNA analysis involves collecting and analyzing these minute samples to extract the DNA and generate a DNA profile. The DNA profile contains unique genetic markers that can be compared to known DNA samples, such as those from a suspect or a DNA database, to determine a potential match or identify an unknown individual.The process of touch DNA analysis typically involves the following steps:Sample collection: Forensic investigators collect potential touch DNA samples from objects or surfaces at a crime scene using various techniques. This may involve swabbing the surface with a sterile cotton swab or using adhesive tape to lift any visible or invisible biological material.DNA extraction: The collected samples undergo a DNA extraction process to isolate the DNA from other substances present on the surface. This step aims to purify the DNA and remove any potential inhibitors that might interfere with subsequent analysis.DNA amplification: The extracted DNA is subjected to a process called polymerase chain reaction (PCR), which amplifies specific regions of the DNA. PCR allows for the generation of sufficient DNA material for further analysis, even if only a minimal amount of touch DNA was initially present.DNA profiling: The amplified DNA is analyzed using techniques such as short tandem repeat (STR) analysis. STR markers are specific regions within the DNA that exhibit variations in the number of repeated DNA sequences. By comparing the lengths of these STR markers between the crime scene sample and a reference sample, a DNA profile is generated.Database search and interpretation: The DNA profile obtained from the touch DNA sample can be compared to known reference samples from suspects or individuals in a DNA database. If a match is found, it can provide investigative leads or potentially establish a link between the individual and the crime scene.It's important to note that touch DNA analysis has certain limitations. The amount of DNA left behind through touch is often very small, making it susceptible to contamination and degradation. Factors such as the environmental conditions and the time elapsed since the DNA was deposited can affect the quality and quantity of the touch DNA sample. Additionally, the presence of multiple individuals' DNA on an object or surface can complicate the analysis.Nevertheless, touch DNA analysis has proven valuable in numerous criminal investigations, aiding in the identification of suspects, establishing links between individuals and crime scenes, and exonerating innocent individuals. It is a powerful tool in forensic science that complements other methods of DNA analysis, such as blood or saliva DNA samples."The comparison showed a statistical match—specifically, the STR profile is at least 5.37 octillion times more likely to be seen if Defendant is the source than if an unrelated individual randomly selected from the population is the source," the filing says according to the article.In this episode we take a look at how strong that evidence is and how Kohberger's team might attempt to challenge it.(commercial at 7:40)to contact me:bobbycapucci@protonmail.comsource:Bryan Kohberger DNA Revelation Made in New Court Documents (newsweek.com)Become a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.
IVF Clinic Bombing and Pro-Mortalism Ideology (00:02:09 - 00:09:27)Guy Edward Bartkus bombed a Palm Springs IVF clinic, killing himself and injuring five, motivated by pro-mortalism (life causes suffering, death is liberation). His manifesto, hosted on promortalism.com, rails against pro-lifers and life itself, reflecting a nihilistic, anti-human philosophy rooted in online subcultures.Cultural Nihilism and Social Media's Role (00:13:03 - 00:24:28)The bomber's pro-mortalism reflects a broader cultural nihilism, influenced by ideas like Gaia theory (humans as a virus) and amplified by social media platforms. Reddit, TikTok, and Tumblr are criticized as hubs for pseudo-intellectualism, fostering anti-life ideologies among isolated individuals.Bible Engagement as a Positive Trend (00:24:28 - 00:31:02)A LifeWay survey shows 48% of Americans view the Bible as true (up from 36% in 2016), with rising Bible sales and reading. This suggests a growing rejection of secular humanism and a return to spiritual values amid cultural nihilism.Covid as a Scam (Music Man Analogy) (00:41:36 - 00:50:18)A Brownstone Institute article compares the Covid response to The Music Man, where fear (inflated death counts, PCR test misuse) enriched “snake oil salesmen” like Fauci. This mirrors historical fearmongering (9/11, Waco) to erode rights, with elites profiting from compliance.Trump's Tariffs Impact on Small Businesses (01:11:21 - 01:16:20)An NFIB survey shows Trump's unpredictable tariffs are reducing small business optimism (down to 95.8, below the 51-year average), creating market uncertainty akin to Covid-era disruption. Small businesses face tight margins, reduced hiring, and stalled investments, with tech sector impacts highlighted by YouTubers Louis Rossman and Gamers Nexus.DEA Corruption in Drug War (01:27:30 - 01:35:58)An AP article reveals Diego Marin, a Cali cartel figure, evaded capture with DEA complicity, bribing agents while building a $100M money-laundering empire. Compared to Whitey Bulger and Iran-Contra, it's framed as a problem-reaction-solution tactic to expand the police state.Mexican Navy Ship Crash (01:37:07 - 01:39:26)An NBC News report describes a Mexican Navy sailing ship crashing into the Brooklyn Bridge, killing two and injuring 22 due to a mechanical failure. The surreal event stunned New Yorkers, highlighting the unexpected nature of Mexico's sailing navy.CDC Covid Vaccine Recommendations (01:52:26 - 01:56:33)A Wall Street Journal article reports the Trump administration plans to drop routine Covid vaccine recommendations for pregnant women, teenagers, and children, led by HHS Secretary RFK Jr. The host criticizes the CDC's blanket recommendation (everyone 6 months and older) due to no long-term safety data, profit-driven motives, and harmful side effects, arguing the vaccine should be removed entirely.HHS Covid Vaccine Recommendations and Authority (02:05:33 - 02:13:16)Dr. Ruby critiques HHS's plan to stop recommending Covid vaccines for children and pregnant women as a red herring, given its authority over FDA, NIH, CMS, and CDC to demand immediate removal. She warns of deceptive terms like “considering” and questions state chemtrail bans, citing federal exemptions (Title 50, Prep Act) and global air circulation, suspecting controlled opposition.Novavax Approval Critique and Bird Flu (02:21:20 - 02:30:03)The FDA fully approved Novavax's Covid shot, marketed as non-mRNA but using synthetic spike proteins from moth cells, posing risks like myocarditis with no long-term studies. Dr. Ruby warns of off-label use and compares it to Pfizer/Moderna's rollout. She critiques bird flu as a fabricated threat, with chicken culling inflating egg prices and testing economic control, not addressing real disease.Vaccine Shedding and Industry Protections (02:16:43 - 02:51:36)Pfizer's investigator brochure admits Covid vaccine shedding via inhalation and skin contact, raising concerns about unknown contents affecting unvaccinated individuals. Dr. Ruby highlights the vaccine industry's Prep Act immunity, with government payouts in vaccine court, and Pfizer's 50% non-disclosure agreement, allowing undisclosed ingredients, akin to coercive contracts demanding country assets.Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
IVF Clinic Bombing and Pro-Mortalism Ideology (00:02:09 - 00:09:27)Guy Edward Bartkus bombed a Palm Springs IVF clinic, killing himself and injuring five, motivated by pro-mortalism (life causes suffering, death is liberation). His manifesto, hosted on promortalism.com, rails against pro-lifers and life itself, reflecting a nihilistic, anti-human philosophy rooted in online subcultures.Cultural Nihilism and Social Media's Role (00:13:03 - 00:24:28)The bomber's pro-mortalism reflects a broader cultural nihilism, influenced by ideas like Gaia theory (humans as a virus) and amplified by social media platforms. Reddit, TikTok, and Tumblr are criticized as hubs for pseudo-intellectualism, fostering anti-life ideologies among isolated individuals.Bible Engagement as a Positive Trend (00:24:28 - 00:31:02)A LifeWay survey shows 48% of Americans view the Bible as true (up from 36% in 2016), with rising Bible sales and reading. This suggests a growing rejection of secular humanism and a return to spiritual values amid cultural nihilism.Covid as a Scam (Music Man Analogy) (00:41:36 - 00:50:18)A Brownstone Institute article compares the Covid response to The Music Man, where fear (inflated death counts, PCR test misuse) enriched “snake oil salesmen” like Fauci. This mirrors historical fearmongering (9/11, Waco) to erode rights, with elites profiting from compliance.Trump's Tariffs Impact on Small Businesses (01:11:21 - 01:16:20)An NFIB survey shows Trump's unpredictable tariffs are reducing small business optimism (down to 95.8, below the 51-year average), creating market uncertainty akin to Covid-era disruption. Small businesses face tight margins, reduced hiring, and stalled investments, with tech sector impacts highlighted by YouTubers Louis Rossman and Gamers Nexus.DEA Corruption in Drug War (01:27:30 - 01:35:58)An AP article reveals Diego Marin, a Cali cartel figure, evaded capture with DEA complicity, bribing agents while building a $100M money-laundering empire. Compared to Whitey Bulger and Iran-Contra, it's framed as a problem-reaction-solution tactic to expand the police state.Mexican Navy Ship Crash (01:37:07 - 01:39:26)An NBC News report describes a Mexican Navy sailing ship crashing into the Brooklyn Bridge, killing two and injuring 22 due to a mechanical failure. The surreal event stunned New Yorkers, highlighting the unexpected nature of Mexico's sailing navy.CDC Covid Vaccine Recommendations (01:52:26 - 01:56:33)A Wall Street Journal article reports the Trump administration plans to drop routine Covid vaccine recommendations for pregnant women, teenagers, and children, led by HHS Secretary RFK Jr. The host criticizes the CDC's blanket recommendation (everyone 6 months and older) due to no long-term safety data, profit-driven motives, and harmful side effects, arguing the vaccine should be removed entirely.HHS Covid Vaccine Recommendations and Authority (02:05:33 - 02:13:16)Dr. Ruby critiques HHS's plan to stop recommending Covid vaccines for children and pregnant women as a red herring, given its authority over FDA, NIH, CMS, and CDC to demand immediate removal. She warns of deceptive terms like “considering” and questions state chemtrail bans, citing federal exemptions (Title 50, Prep Act) and global air circulation, suspecting controlled opposition.Novavax Approval Critique and Bird Flu (02:21:20 - 02:30:03)The FDA fully approved Novavax's Covid shot, marketed as non-mRNA but using synthetic spike proteins from moth cells, posing risks like myocarditis with no long-term studies. Dr. Ruby warns of off-label use and compares it to Pfizer/Moderna's rollout. She critiques bird flu as a fabricated threat, with chicken culling inflating egg prices and testing economic control, not addressing real disease.Vaccine Shedding and Industry Protections (02:16:43 - 02:51:36)Pfizer's investigator brochure admits Covid vaccine shedding via inhalation and skin contact, raising concerns about unknown contents affecting unvaccinated individuals. Dr. Ruby highlights the vaccine industry's Prep Act immunity, with government payouts in vaccine court, and Pfizer's 50% non-disclosure agreement, allowing undisclosed ingredients, akin to coercive contracts demanding country assets.Follow the show on Kick and watch live every weekday 9:00am EST – 12:00pm EST https://kick.com/davidknightshow Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code KNIGHT Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
In this episode, we're joined by molecular biologist Dr. Jerneja Tomsic for a thorough, start-to-finish dismantling of PCR, the method that underpins much of modern diagnostic virology.We begin with foundational principles—Koch's postulates, isolation vs. purification, and the philosophical failures of modern science. Dr. Tomsic walks us through the basics of PCR, exposing its misuse in clinical settings and the flawed assumptions baked into its application.From there, we challenge the idea of asymptomatic carriers, the nonsense of virology, and the sleight of hand involved in viral sequencing, primer creation, and metagenomics.This is not just a technical critique—it's a deeper reflection on scientific corruption, narrative manipulation, and the role of fear as the real virus.If you've ever questioned the foundations of modern "infectious disease" science, this episode is essential listening.Keep up with me (socials)https://www.instagram.com/beyond.terrain/https://beyondterrain.com/Our vision at Beyond Terrain is best supported by sharing our work!Joining our private terrain community is also a wonderful way to support what we do here at Beyond Terrain.https://beyondterrain.com/beyond-terrain-community/Learn more from and support our esteemed guest, Dr. Tomsichttps://x.com/zianiniSLO
Hosťom relácie Dírerov filter bol biochemik Pavol Čekan. Okrem biochémie sa venuje výskumu v oblasti molekulárnej biológie a diagnostiky rakoviny prsníka. Študoval na univerzitách na Islande a Spojených štátoch, kde neskôr aj pracoval v Národnom onkologickom inštitúte. Na Slovensku sa do povedomia verejnosti dostal počas pandémie koronavírusu za vývoj PCR testov, ktoré sa dodnes používajú po celom svete. Za tento vynález získal viaceré významné ocenenia doma i vo svete.
What happens when scientific curiosity meets life-changing opportunity? Nicole Mumbi shares her remarkable journey and provides a powerful answer to this question.Moving from Nairobi, Kenya to Boston in 2019, Nicole faced the challenge of cultural transition while nurturing her budding interest in science. Though initially experiencing culture shock and language barriers, her determination never wavered. A simple middle school experiment on atmospheric pressure had already planted the seed of scientific fascination that would shape her future path.When Nicole's high school guidance counselor suggested applying to the BioBuilder Apprenticeship Program, she seized the opportunity despite her fears and busy academic schedule. At Ginkgo Bioworks' Learning Lab, Nicole and her team developed "Break the Stigma" – an innovative at-home HIV detection project that engineered bacterial cells with CD4 receptors to detect the virus in blood samples. This first-hand laboratory experience transformed her understanding of science from textbook concepts to real-world applications.The technical skills Nicole gained – from PCR to scientific presentation – became the foundation for her subsequent internship at the prestigious Ragon Institute. Now thriving as a Biochemistry and Molecular Biology student at UMass Amherst, she gives back by tutoring other students in chemistry while contemplating whether her future lies in research, medicine, or a combination of both.Throughout her story, Nicole emphasizes the importance of pushing past imposter syndrome to take chances. "I remember having this imposter syndrome person talking to me saying, 'I don't think you have enough qualifications,'" she shares. "But I was grateful for my mom's encouragement to partake in opportunities without feeling like an outsider."Learn more about BioBuilder's programs for students, educators, and industry professionals here
For years, scientists thought nothing could live above 73℃/163℉. At that temperature, everything boiled to death. But scientists Tom Brock and Hudson Freeze weren't convinced. What began as their simple quest to trawl for life in some of the hottest natural springs on Earth would, decades later, change the trajectory of biological science forever, saving millions of lives—possibly even yours.This seismic, totally unpredictable discovery, was funded by the U.S. government. This week, as the Trump administration slashes scientific research budgets en masse, we tell one story, a parable about the unforeseeable miracles that basic research can yield. After that, a familiar voice raises some essential questions: what are we risking with these cuts? And can we recover?Special thanks to Joanne Padrón Carney, Erin Heath, Valeria Sabate, Gwendolyn Bogard, Meredith Asbury and Megan Cantwell at AAAS. Thank you as well to Gregor Čavlović and Derek Muller and the rest of the Veritasium team.EPISODE CREDITS: Reported by - Latif Nasserwith help from - Maria Paz GutiérrezProduced by - Sarah Qari and Maria Paz GutiérrezOriginal music and sound design and mixing from - Jeremy BloomFact-checking by - Emily Kreigerand Edited by - Alex Neason with help from Sarah QariEPISODE CITATIONS:Videos - Latif also helped make a version of this story with the YouTube channel Veritasium. Articles - Hudson Freeze NYT OPED: Undercutting the Progress of American ScienceBooks -Thomas Brock, A Scientist in Yellowstone National ParkPaul Rabinow's Making PCR: A Story of BiotechnologyPodcasts Episodes:If you haven't heard, listen to our first episode about the Golden Goose awards. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.Leadership support for Radiolab's science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.
The scientific method involves observation, questioning, forming hypotheses, testing predictions and altering theories to align with results; it is not the altering of results to align with a hypothesis. There are three acceptable narratives about COVID-19: a wet mart (official), 5G (conspiracy), and laboratory leak (alternative). Whereas the https://www.science.org/content/article/cia-bribed-its-own-covid-19-origin-team-reject-lab-leak-theory-anonymous-whistleblower to reject the lab theory, https://apnews.com/article/covid-cia-trump-china-pandemic-lab-leak-9ab7e84c626fed68ca13c8d2e453dde1 explanation. This announcement was made just days after the former President regained the White House. As of April 2025, the https://www.whitehouse.gov/lab-leak-true-origins-of-covid-19/?fbclid=IwY2xjawJv5wdleHRuA2FlbQIxMAABHrhaCm1LYQx2UbG8uGLw5gkhCvB3N4a2gNrAgdarT7Z6C-XKZijSXHb3PctU_aem_hUJWc6XJ_Gfj14AvDa1VSA as “the true origins of COVID-19.” This new official designation means that at one time or another two totally different explanations were given, ultimately with the consequence of censorship and ridicule if a person thought or said anything different. Both explanations still result in justufciaotn for past, and future, measures such as: social distancing, masking, https://www.theatlantic.com/ideas/archive/2021/04/end-hygiene-theater/618576/ as a form of a theater, vaccines, etc. Prior to the recent shift in narratives, undercover video reportedly proved that Pfizer was indeed conducing gain of function research in a laboratory. But that lab was not a viral facility or a Wuhan institute; instead, it was a computer lab. In fact, https://www.pfizer.com/news/announcements/pfizer-responds-research-claims stating: “With a naturally evolving virus, it is important to routinely assess the activity of an antiviral. Most of this work is conducted using computer simulations…” Such computer simulations were used to predict mass casualties from COVID, too, and are the same ones being employed for Climate Change narratives. But what is COVID-19 or the virus designated SARS-COV-2. It is a list or complex of symptoms that are classified into categories of disease. Examination of COVID's symptoms prove they are nearly identical to the common cold and flu, among others. In fact, the https://hsph.harvard.edu/news/a-sharp-drop-in-flu-cases-during-covid-19-pandemic/. According to Harvard, this was the result of “wearing masks and distancing,” though they did not explain how such measures stopped the flu but not SARS-COV-2. Consider these three sets of symptoms from the CDC website: https://www.cdc.gov/common-cold/about/index.html: runny nose or nasal congestion, cough, sneezing, sore throat, headache, mild body aches, fever.https://www.cdc.gov/flu/signs-symptoms/index.html: runny or stuffy nose, cough, sore throat, headaches, muscle or body aches, fatigue, fever, and vomiting or diarrhea. https://www.cdc.gov/covid/signs-symptoms/index.html: congestion or runny nose, cough, sore throat, headache, muscle or body aches, fatigue, fever or chills, nausea or vomiting, and diarrhea. The only distinct symptoms of COVID were “shortness of breath or difficulty breathing” and “new loss of taste or smell.” The first symptom is already https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm in the United States - chronic lower respiratory disease. Since COVID was first tested CLRD has been bumped to sixth, though many of these respiratory deaths have been listed as COVID. In other words, what would have been diagnosed as CLRD was categorized instead as COVID-19. This is the same reason flu nearly disappeared as reported cases. These breathing problems were, within the COVID diagnosis, themselves sub-categorized as COVID-Pneumonia, and https://my.clevelandclinic.org/health/diseases/24002-covid-pneumonia. The second symptom of losing a senes of taste or smell varied between total loss and partial loss, something that also occurs with the common cold and flu. This distinct and often promoted https://www.healthline.com/health-news/who-is-most-likely-to-lose-their-sense-of-smell-and-taste-from-covid-19, and even so only involved some often minor or unspecified form of loss. Thus we can determine that between 15-37% of COVID cases had “distinct” symptoms arguably different than the overall symptoms that classify cold or flu, which means at liberal estimates over two thirds of COVID cases were nothing more than a case of the cold or flu. When defining what caused these other symptoms, we know recategorized pneumonia was one. But what about other causes that resulted in loss of senses? Other than injuries or inflammation, often caused by what we call allergies, https://www.livestrong.com/article/13731552-food-suddenly-tastes-different/ and https://pubmed.ncbi.nlm.nih.gov/27178656/, as can neurological disorders. Other than the obvious and physical, there is also the psychological. Anxiety and stress are well known to alter sense perceptions, including https://www.calmclinic.com/anxiety/signs/smell and https://pmc.ncbi.nlm.nih.gov/articles/PMC10668578/. Consider how much anxiety and stress were cultivated by 24-hour coverage of cases, deaths, symptoms, videos from China, etc., and how wiling the public was to adopt any perceptually legal or even illogical dictate for the purposes of keeping themselves and others “safe.” There is a long history of such mass psychogenic pathogen.Much of this fear was generated by variant names like “KRAKEN,” a mythical monster, as was https://www.unmc.edu/healthsecurity/transmission/2023/09/19/meet-the-man-who-named-covids-new-variants/ who likewise believed this naming heightened the public's perception of a terror they should be feeling. Such fear became so intense that one analysis suggested that COVID activated “archetypes of evil” and thus “added psychological suffering.” The study suggested: “Fear and grief caused by the pandemic have produced a powerful unconscious narrative in the collective psyche that the coronavirus is driven by an https://pmc.ncbi.nlm.nih.gov/articles/PMC8441919/. The resulting archetypal dimension of fear causes an extra layer of psychological suffering in individuals.” Such mythical, theological, and even magical terms were not lost in the New England Journal of Medicine which openly declared in 2020 that masks were little more than talismans: “Masks are not only tools, https://www.nejm.org/doi/full/10.1056/NEJMp2006372...” A spirit or demon possessing a body is an impure form that makes one sick. Items such as crosses or holy water are employed in its exorcism - to exercise/exorcise the demon and make healthy again - along with the name of the unclean. The same is done today in modern vaccine administration. The holy water is replaced by a vaccine vial, the cross is replaced by a syringe and plunger, the demon's name is replaced by the variant or virus name, and the ritual robes are replaced by white lab coats. The pandemic was not about a virus and a distinct set of symptoms. Instead it was about inducing archetypical fear and https://www.weforum.org/stories/2020/10/the-rich-got-richer-during-the-pandemic-and-that-s-a-daunting-sign-for-our-recovery/. It was at best https://www.history.com/articles/mysterious-illnesses-mass-hysteria, in the middle a conspiracy of fraud and psychological terror, and at worst a dark magical ritual to induce trauma. Further evidence of the fraud can be found in reports like this one from the New York Times that discuss the ultra amplification of PCR testing cycles from the low 30s to the mid 40s -“https://absa.org/wp-content/uploads/2020/09/NYT-200829-Your-Coronavirus-Test.pdf” - “In three sets of testing data that include cycle thresholds, compiled by officials in Massachusetts, New York and Nevada, up to 90 percent of people testing positive carried barely any virus…In Massachusetts, from 85 to 90 percent of people who tested positive in July with a cycle threshold of 40 would have been deemed negative if the threshold were 30 cycles.” Even ‘true' positive tests do not indicate symptoms or disease, or the future development of such, which brings us back to the White House website and the statement about the lab leak: “The virus possesses a biological characteristic that is not found in nature.” This may be true, as per whatever is being assumed to exist, or observed under a microscope, or played with in a computer model, yet it does not prove any disease, especially in https://abcnews.go.com/Health/covid-transmission-asymptomatic/story?id=84599810. *The is the FREE archive.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-secret-teachings--5328407/support.
Scientific discovery happens in the lab—but it starts with curiosity and determination. In this episode of Absolute Gene-ius, we welcome Valeria Rangel, a PhD candidate at the University of California Irvine, who shares her research on acute lymphoblastic leukemia and the innovative ways digital PCR is helping uncover genetic patterns linked to cancer in Hispanic populations.Val's work focuses on Philadelphia chromosome-like (Ph-like) B-cell acute lymphoblastic leukemia, a rare and aggressive form of cancer. She explains how her lab uses digital PCR to detect mutations with high precision, identify risk factors in certain populations, and even validate findings using CRISPR-Cas9 gene editing. Through her research, Val sheds light on the role of SNPs, methylation patterns, and translocations in leukemia progression—demonstrating how digital PCR is transforming the way we approach cancer research.Beyond the science, Val takes us on her personal journey, from struggling to break into research due to financial barriers to finding her passion in oncology. In this episode's Career Corner, she shares valuable advice for aspiring scientists, tips for landing research opportunities, and some of her most hilarious and humbling lab moments (yes, she has broken multiple pipettes).Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System.
In this episode of the RWS Clinician's Corner, Margaret Floyd Barry has an enlightening discussion featuring Dr. Betty Murray, a leading expert in women's health and hormone metabolism. Dr. Betty dives deep into the intricate role of the enzyme beta glucuronidase and how it impacts everything from detoxification processes to hormone balance, particularly in women over 40. We also unpack the symbiotic relationship between hormones and the microbiome, and how this understanding can transform clinical practices. In this interview, we discuss: -What beta glucuronidase is and the relationship between hormones and the microbiome -How microbiome changes with age and hormones - and its potential benefits -The approach to testing for beta glucuronidase in conjunction with other tests -The role of diet and supplements in managing microbiome and enzyme levels -The concept of creating a healthier biome environment rather than targeting individual strains The Clinician's Corner is brought to you by Restorative Wellness Solutions. Follow us: https://www.instagram.com/restorativewellnesssolutions/ Connect with Dr. Betty Murray: Websites: https://bettymurray.com; https://livingwelldallas.com; and https://getmenrva.com YouTube: https://www.youtube.com/@drbettymurray and https://www.youtube.com/@MenopauseMasteryShow Instagram: https://www.instagram.com/drbettymurray/ Facebook: https://www.facebook.com/drbettymurray LinkedIn: https://www.linkedin.com/in/bettymurray/ Resources from Dr. Betty: Assessing the Microbiome in Clinical Practice Presentation from the Archives: https://youtu.be/nvbAE3oVec0 A Girl's Guide to Estrogen Dominance: https://ed.hormoneshelp.com/ Timestamps: 00:00 From Christian Science to Functional Medicine 10:13 Rethinking Beta Glucuronidase's Role 11:42 Menopause, Microbiome, and Hormones 17:20 Hormones' Impact on IBS Severity 25:02 Hormone Metabolism Insights in Telemedicine 28:42 Researching Age-Specific Functional Medicine 37:37 Clinician's Corner: Gut Healing Training 43:21 Dietary Impact on Microbiome Change 48:44 Postbiotic Innovations in Microbiome Therapy 51:45 Understanding Overgrowth Causes 55:51 Constant Relearning and Pattern Recognition 01:02:44 "The Clinician's Corner: Join Us" Speaker bio: Dr. Betty Murray is a women's health advocate, nutrition expert, PhD researcher, certified functional medicine practitioner, author, and speaker. Betty helps women over 40 harness their hormones to lose weight, optimize sleep, restore energy, and thrive. During her research for her Ph.D., Betty made several key discoveries that lead to hormone & metabolic imbalances that plague women over 40. Restoring balance to these key metabolic and hormone pathways is the basis of her Menopause Mastery Program. Dr. Betty is the founder and CEO of Living Well Dallas Functional Medicine Center and Menrva, a national women's telemedicine company providing bioidentical hormone treatment, nutrition, diet, and lifestyle guidance to feel like perimenopause and menopause never happened. She is the host of the Menopause Mastery Podcast, author, and featured writer for Brainz Magazine. As a professional speaker, she has shared the stage with Lisa Nichols, Dr. Mark Hyman, JJ Virgin, Dr. Steven Gundry, Codie Sanchez, Dr. Shrini Pallay, and many others, and she is a frequently featured nutrition expert on Fox News Broadcasting, CW33, NBC, and CBS. Keywords: Beta glucuronidase, estrogen metabolism, hormone imbalance, detoxification, functional medicine, gut health, microbiome, perimenopause, menopause, probiotics, pathogenic species, PCR technology, breast cancer, constipation dominant IBS, hormone metabolites, dietary changes, biofilms, fermented foods, resistant starches, calcium D-glucarate, postbiotics, metagenomics, neurotransmitters, inflammation, histamine, polyphenol-rich foods, nutraceuticals, chemotherapy toxicity, lipopolysaccharide, Gilberts syndrome Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.
Broadcast from KSQD, Santa Cruz on 4-10-2025: Dr. Dawn responds to an email about difficult-to-control asthma, recommending quercetin and inhaled cromolyn as mast cell stabilizers, and suggesting Montelukast to address leukotrienes while investigating possible mold exposure as an underlying cause. She discusses groundbreaking research on age-related bone deterioration, explaining how osteocytes undergo structural changes with age, and exploring the concept of cellular senescence including potential treatments like quercetin/dasatinib combination therapy, fisetin, and metformin. A frequent caller with a history of sepsis, osteomyelitis and eye infections describes newly developed high blood pressure, with Dr. Dawn explaining how oxidative stress from infection can damage endothelial cells, reducing nitric oxide production and suggesting L-arginine, beet consumption, and proper blood pressure measurement techniques. Responding to an email about preventing cartilage loss, Dr. Dawn evaluates glucosamine sulfate research, noting key differences between effective and ineffective studies, while emphasizing the importance of achieving healthy body weight as a primary factor in preventing osteoarthritis progression. Dr. Dawn provides guidance to an email question about choosing a primary care physician before retirement, recommending selecting doctors established in their practice for 3-4 years and warning against Medicare Advantage plans that limit provider options. She addresses an email from someone experiencing persistent fatigue following Epstein-Barr virus reactivation, suggesting additional testing to confirm viral load through PCR rather than relying solely on antibody levels, while exploring alternative causes including long COVID, mold exposure, or autoimmune issues.
Broadcast from KSQD, Santa Cruz on 4-10-2025: Dr. Dawn responds to an email about difficult-to-control asthma, recommending quercetin and inhaled cromolyn as mast cell stabilizers, and suggesting Montelukast to address leukotrienes while investigating possible mold exposure as an underlying cause. She discusses groundbreaking research on age-related bone deterioration, explaining how osteocytes undergo structural changes with age, and exploring the concept of cellular senescence including potential treatments like quercetin/dasatinib combination therapy, fisetin, and metformin. A frequent caller with a history of sepsis, osteomyelitis and eye infections describes newly developed high blood pressure, with Dr. Dawn explaining how oxidative stress from infection can damage endothelial cells, reducing nitric oxide production and suggesting L-arginine, beet consumption, and proper blood pressure measurement techniques. Responding to an email about preventing cartilage loss, Dr. Dawn evaluates glucosamine sulfate research, noting key differences between effective and ineffective studies, while emphasizing the importance of achieving healthy body weight as a primary factor in preventing osteoarthritis progression. Dr. Dawn provides guidance to an email question about choosing a primary care physician before retirement, recommending selecting doctors established in their practice for 3-4 years and warning against Medicare Advantage plans that limit provider options. She addresses an email from someone experiencing persistent fatigue following Epstein-Barr virus reactivation, suggesting additional testing to confirm viral load through PCR rather than relying solely on antibody levels, while exploring alternative causes including long COVID, mold exposure, or autoimmune issues.
Episode 188: RSV Management and PreventionDr. Sandhu and future Dr. Mohamed summarize the management of RSV and describe how to prevent it with chemoprophylaxis and vaccines. Dr Arreaza adds some comments about RSV vaccines.Written by Abdolhakim Mohamed, MSIV, Ross University School of Medicine. Comments by Ranbir Sandhu, MD, and Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.What is RSV? -The Respiratory syncytial Virus (RSV) is an enveloped, negative-sense, single-stranded RNA virus of the Orthopneumovirus genus within the Pneumoviridae family. -RSV is a major cause of acute respiratory tract infections, particularly bronchiolitis and pneumonia, in infants and young children, and it also significantly affects older adults and immunocompromised individuals. -RSV infections cause an estimated 58,000–80,000 hospitalizations among children younger than 5 years and 60,000–160,000 hospitalizations among adults older than 65 years each year.-RSV is highly contagious and spreads through respiratory droplets and direct contact with contaminated surfaces. The virus typically causes seasonal epidemics, peaking in the winter months in temperate climates and during the rainy season in tropical regions. -Virtually all children are infected with RSV by the age of two, and reinfections can occur throughout life, often with milder symptoms.-Per the 2014 Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis, from the American Academy of Pediatrics, the most common etiology of bronchiolitis is RSV. -About 97% of children are infected with RSV in the first 2 years of life, about 40% will experience lower respiratory tract infection during the initial infection. Other viruses that cause bronchiolitis include human rhinovirus, human metapneumovirus, influenza, adenovirus, coronavirus, and parainfluenza viruses.When is RSV season?-Classically, the highest incidence of infection occurs between December and March in North America. Per CDC, there were typical prepandemic RSV season patterns, but the COVID-19 pandemic disrupted RSV seasonality during 2020–2022. -Before we dive into the seasonality patterns, for context, in order to describe RSV seasonality in the US, data was gathered and analyzed from polymerase chain reaction (PCR) test results reported to the National Respiratory and Enteric Virus Surveillance System (NREVSS) during July 2017–February 2023. -Seasonal RSV epidemics were defined as the weeks during which the percentage of PCR test results that were positive for RSV was ≥3%. Per 2017–2020 data, RSV epidemics in the United States typically follow seasonal patterns, that began in October, peaked in December or January, and ended in April. -However, during 2020–21, the typical winter RSV epidemic did not occur. The 2021–22 season began in May, peaked in July, and ended in January. -The 2022–23 season started (June) and peaked (November) later than the 2021–22 season, but earlier than prepandemic seasons. CDC notes that the timing of the 2022–23 season suggests that seasonal patterns are returning toward those observed in prepandemic years, however, warn that clinicians should be aware that off-season RSV circulation might continue.Treatment of RSVSome key points of the 2014 pediatric guidelines from the American Academy of Pediatrics.-AAP strongly do not recommend beta agonists or steroids for viral associated bronchiolitis because of no significant improved outcomes. “Clinicians should not administer albuterol (or salbutamol) to infants and children with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation Strength: Strong Recommendation).”-Epinephrine is not recommended for infants and children with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation Strength: Strong Recommendation).-Nebulized hypertonic saline should not be administered to infants with a diagnosis of bronchiolitis in the emergency department (Evidence Quality: B; Recommendation Strength: Moderate Recommendation), but hypertonic saline may be administered when they are hospitalized (Evidence Quality: B; Recommendation Strength: Weak Recommendation [based on randomized controlled trials with inconsistent findings]).-Chest physiotherapy should not be used in infants and children with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation Strength: Moderate Recommendation).-Antibiotics should not be administered in bronchiolitis unless there is a concomitant bacterial infection, or a strong suspicion of one (Evidence Quality: B; Recommendation Strength: Strong Recommendation).-Oxygen therapy may not be administered if the oxyhemoglobin saturation exceeds 90% in infants and children with a diagnosis of bronchiolitis (Evidence Quality: D; Recommendation Strength: Weak Recommendation [based on low level evidence and reasoning from first principles]).-Clinicians should administer nasogastric or intravenous fluids for infants with a diagnosis of bronchiolitis who cannot maintain hydration orally (Evidence Quality: X; Recommendation Strength: Strong Recommendation).How do we prevent RSV?Infant Immuno-prophylaxis:A clinical trial in 2022 demonstrated that a single injection of nirsevimab (Beyfortus®), administered before the RSV season, protected healthy late-preterm and term infants from RSV-associated lower respiratory tract that required medical treatment. Nirsevimab is a monoclonal antibody to the RSV fusion protein that has an extended half-life.Additionally, on August 3, 2023, the Advisory Committee on Immunization Practices (ACIP) recommended nirsevimab for all infants younger than 8 months who are born during or entering their first RSV season and for infants and children between 8-19 months who are at increased risk for severe RSV disease and are entering their second RSV season. On the basis of pre-COVID-19 pandemic patterns, nirsevimab could be administered in most of the continental United States from October through the end of March.Maternal Vaccination: The CDC recommends the administration of the RSVPreF vaccine to pregnant women between 32 0/7 and 36 6/7 weeks of gestation. This vaccination aims to reduce the risk of RSV-associated lower respiratory tract infection in infants during the first 6 months of life.At this time, if a pregnant woman has already received a maternal RSV vaccine during any previous pregnancy, CDC does not recommend another dose of RSV vaccine during subsequent pregnancies.Older individuals: -Each year in the U.S., it is estimated that between 60,000 and 160,000 older adults are hospitalized and between 6,000 and 10,000 die due to RSV infection-ABRYSVO's approval will help offer older adults protection in the RSV season.-On June 26, 2024, ACIP voted to give these recommendations: all adults older than 75 years and adults between 60–74 years who are at increased risk for severe RSV disease should receive a single dose of RSV vaccine (Abrysvo®).Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Hamid S, Winn A, Parikh R, et al. Seasonality of Respiratory Syncytial Virus — United States, 2017–2023. MMWR Morb Mortal Wkly Rep 2023;72:355–361. DOI: http://dx.doi.org/10.15585/mmwr.mm7214a1Hammitt LL, Dagan R, Yuan Y, Baca Cots M, Bosheva M, Madhi SA, Muller WJ, Zar HJ, Brooks D, Grenham A, Wählby Hamrén U, Mankad VS, Ren P, Takas T, Abram ME, Leach A, Griffin MP, Villafana T; MELODY Study Group. Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants. N Engl J Med. 2022 Mar 3;386(9):837-846. doi: 10.1056/NEJMoa2110275. PMID: 35235726.Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, Johnson DW, Light MJ, Maraqa NF, Mendonca EA, Phelan KJ, Zorc JJ, Stanko-Lopp D, Brown MA, Nathanson I, Rosenblum E, Sayles S 3rd, Hernandez-Cancio S; American Academy of Pediatrics. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014 Nov;134(5):e1474-502. doi: 10.1542/peds.2014-2742. Erratum in: Pediatrics. 2015 Oct;136(4):782. doi: 10.1542/peds.2015-2862. PMID: 25349312.CDC, per their published article Seasonality of Respiratory Syncytial Virus — United States for 2017–2023, in the United StatesWhat U.S. Obstetricians Need to Know About Respiratory Syncytial Virus.Debessai H, Jones JM, Meaney-Delman D, Rasmussen SA. Obstetrics and Gynecology. 2024;143(3):e54-e62. doi:10.1097/AOG.0000000000005492.Maternal Respiratory Syncytial Virus Vaccination and Receipt of Respiratory Syncytial Virus Antibody (Nirsevimab) by Infants Aged
Season 5: Episode 207In this North American Ag Spotlight podcast episode, host Chrissy Wozniak interviews Katie Pasitney from Universal Ostrich, a family-owned ostrich farm in British Columbia, Canada. The farm, which has been raising ostriches for 35 years, is facing a crisis due to a government order to cull over 400 ostriches amid an avian flu outbreak, despite most birds showing resistance and antibodies to the virus.Katie explains that the farm has shifted focus in recent years to groundbreaking antibody research in collaboration with Kyoto Prefectural University in Japan. They inoculate ostriches with antigens to produce robust antibodies in their egg yolks, which could be used to create nutraceuticals like lozenges and nasal sprays to boost human immunity against diseases, including COVID-19 variants. This research has shown promising results, with one ostrich egg containing antibodies equivalent to 100 chicken eggs or the blood of 800 rabbits, offering a humane and efficient alternative.The crisis began in December 2024 when the farm noticed symptoms similar to a 2020 pseudomonas bacteria outbreak, initially linked to migratory mallard ducks. However, the Canadian Food Inspection Agency (CFIA), acting on an anonymous tip, tested two deceased ostriches and confirmed H5N1 avian influenza using PCR tests, rejecting the farm's request to test healthy birds or conduct a broader study. Despite the farm's isolation and the ostriches' apparent herd immunity—evidenced by 76 days without symptomatic deaths post-quarantine—the CFIA ordered the entire flock's destruction, citing trading partner policies influenced by the World Health Organization and the UN.Katie highlights the farm's struggle against what she calls a “stamping out” policy that prioritizes mass culling over preserving natural immunity, potentially benefiting Big Pharma by eliminating alternatives to vaccines. The CFIA has threatened a $250,000 fine or jail time if the farm tests its own animals, and even probed for intellectual property during a 5.5-hour meeting, despite having already signed a kill order on December 30, 2024. The family faces a deadline to kill and bury the ostriches themselves or lose compensation if a third-party contractor intervenes.With a judicial review scheduled for mid-April, the farm is fighting legally to save their ostriches and research, having raised over $60,000 for legal fees but facing $100,000 more in outstanding costs. Katie pleads for public support, emphasizing the global implications for agriculture and natural immunity, and directs listeners to saveourostiches.com for updates and donations.Chrissy underscores the story's urgency, calling for action against government overreach and the preservation of this potentially revolutionary science, urging listeners to share the episode and support the cause. Learn more about this cause at https://bcrising.ca/save-our-ostriches/ and give to the cause at https://www.givesendgo.com/save-our-ostriches or https://www.gofundme.com/f/help-ostrich-farmers-fight-to-save-herd-from-avian-flu?attribution_id=sl%3A80e09934-7413-429b-acfb-2f7015cc19d3&lang=en_CA#ostrich #farming #agricultureDon't just thank a farmer, pray for one toSend us a textAgritechnica in Hannover, Germany is held every other year, this year long-time tech writer & ag journalist Willie Vogt has put together for ag enthusiasts! The Agritechnica tour includes three days at the huge equipment and farm technology event. Learn more - https://agtoursusa.com/agritechnica.htmlSubscribe to North American Ag at https://northamericanag.com
Trump's Liberation Day Tariff ChaosPanic grips the White House as Trump's erratic Liberation Day tariff plans, set for April 2nd, spiral into chaosCar Crisis Unleashed: Trump's Tariffs Jack Prices to the Moon and Trump “couldn't care less”Musk's Mega WinCongress surrenders as Trump seizes tariff reins, spitting on the founders' wisdomDrug Czar Farce: Trump's Pick Shields CIA's Dirty Secrets Silencing Dissent: Dr. Sam Bailey's License Ripped for Defying COVID LiesNew Zealand's Dr. Sam Bailey, MD pays a brutal price—$90,000 fine and license yanked—for daring to question PCR and Trump's shots! And in Canada, a detective is punished for investigating SIDS (Sudden Infant Death Syndrome). Don't look at SIDS or autism! Green Heist: GOP Loves Biden's $4 Trillion Green Tax Credits King Trump's Gambit: Constitution Be Damned for a Third Term“I'm not joking” says Trump about a third term Pardon Payoff Scandal: Trump Cashes In on Criminals Like MiltonParadise Found (or bought) by Milton. Trump's pardon for Nikola's fraudster Milton after a cool $2 million campaign gift! Whistleblowers like Kiriakou reported Giuliani selling Trump pardons, while big-tech crooks buy freedom. Satan's Siege: Churches Vandalized, Black Mass in KansasThe Satanists' strategy and why their claims of “religious equality” should be ignored Schools, Satanists, and the First Amendment ClashOklahoma fights to reclaim religious rights in schools, while Satanists push abortion pills and Daily Wire's attempt to gag “Christ is King” becomes an Easter tradition. From Kenya murders to Idaho lawsuits, faith faces a multi-front war Bodyoid Horror: MIT's Trial Balloon to Grow Humans for Parts Unleashes Ethical HellMIT floats a nightmare—grow “bodyoids” in labs for drugs, organs, maybe meat! No pain, no brains, they claim, but the transhumanist abyss yawns wide. Is this science or a soulless descent into Brave New World? Vaccine Reckoning: Mixed Signals Whether Justice Will Prevail Dr. Vernon Coleman drops a bombshell—doctors who pushed COVID shots could be bankrupt by 2030? Yet Tennessee's Supreme Court stabs workers in the back, siding with Blue Cross Blue Shield to fire the unvaccinated Greenland MAGA: “Make America GO AWAY” Trump's Greenland obsession turns icy as Trump's chilling statement — “a good POSSIBILITY that we could do it without military force” is an implied threat of military force And, Panama Port Power Play as China shuts down the deal with antitrust probes “The Who”, Roger Daltry, says he's going blind & deaf — but he still plays a mean pinball and helps with teen cancer charity as he reflects on aging JFK Bombshell: Alleged NBC's Secret Tape Could Expose Oswald's Innocence What's Behind the Drop in Egg Prices? Mug-Shot! Too Much Coffee in Texas Could Get You a DUI (Driving Under Influence)If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-show Or you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Money should have intrinsic value AND transactional privacy: Go to DavidKnight.gold for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to TrendsJournal.com and enter the code KNIGHTFor 10% off supplements and books, go to RNCstore.com and enter the code KNIGHTBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
Trump's Liberation Day Tariff ChaosPanic grips the White House as Trump's erratic Liberation Day tariff plans, set for April 2nd, spiral into chaosCar Crisis Unleashed: Trump's Tariffs Jack Prices to the Moon and Trump “couldn't care less”Musk's Mega WinCongress surrenders as Trump seizes tariff reins, spitting on the founders' wisdomDrug Czar Farce: Trump's Pick Shields CIA's Dirty Secrets Silencing Dissent: Dr. Sam Bailey's License Ripped for Defying COVID LiesNew Zealand's Dr. Sam Bailey, MD pays a brutal price—$90,000 fine and license yanked—for daring to question PCR and Trump's shots! And in Canada, a detective is punished for investigating SIDS (Sudden Infant Death Syndrome). Don't look at SIDS or autism! Green Heist: GOP Loves Biden's $4 Trillion Green Tax Credits King Trump's Gambit: Constitution Be Damned for a Third Term“I'm not joking” says Trump about a third term Pardon Payoff Scandal: Trump Cashes In on Criminals Like MiltonParadise Found (or bought) by Milton. Trump's pardon for Nikola's fraudster Milton after a cool $2 million campaign gift! Whistleblowers like Kiriakou reported Giuliani selling Trump pardons, while big-tech crooks buy freedom. Satan's Siege: Churches Vandalized, Black Mass in KansasThe Satanists' strategy and why their claims of “religious equality” should be ignored Schools, Satanists, and the First Amendment ClashOklahoma fights to reclaim religious rights in schools, while Satanists push abortion pills and Daily Wire's attempt to gag “Christ is King” becomes an Easter tradition. From Kenya murders to Idaho lawsuits, faith faces a multi-front war Bodyoid Horror: MIT's Trial Balloon to Grow Humans for Parts Unleashes Ethical HellMIT floats a nightmare—grow “bodyoids” in labs for drugs, organs, maybe meat! No pain, no brains, they claim, but the transhumanist abyss yawns wide. Is this science or a soulless descent into Brave New World? Vaccine Reckoning: Mixed Signals Whether Justice Will Prevail Dr. Vernon Coleman drops a bombshell—doctors who pushed COVID shots could be bankrupt by 2030? Yet Tennessee's Supreme Court stabs workers in the back, siding with Blue Cross Blue Shield to fire the unvaccinated Greenland MAGA: “Make America GO AWAY” Trump's Greenland obsession turns icy as Trump's chilling statement — “a good POSSIBILITY that we could do it without military force” is an implied threat of military force And, Panama Port Power Play as China shuts down the deal with antitrust probes “The Who”, Roger Daltry, says he's going blind & deaf — but he still plays a mean pinball and helps with teen cancer charity as he reflects on aging JFK Bombshell: Alleged NBC's Secret Tape Could Expose Oswald's Innocence What's Behind the Drop in Egg Prices? Mug-Shot! Too Much Coffee in Texas Could Get You a DUI (Driving Under Influence)If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-show Or you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Money should have intrinsic value AND transactional privacy: Go to DavidKnight.gold for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to TrendsJournal.com and enter the code KNIGHTFor 10% off supplements and books, go to RNCstore.com and enter the code KNIGHTBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
We have a great Round Up / Lowdown on Canadian specific topics.... You American's might wanna tune in tho! Mass Integration on the rise in Que, Elbows up over Pokemon cards in a Coscto parking lot... guess where. Yep. Brampton PP signalling with letter re Hola Muhola! Meanwhile Danielle Smith starts out with long list for Carneyage to undo for Alberta. Canada - The most European Non European country signals to the EU, meanwhile the EU wants to use their private capital to finance the war machine. You can't make this stuff up. What about Alberta and the national CPP. And did the tariffs on China effect our 600 million dollar investment on China EV's from the CPP? We go over the ICAIE report from late 2023 - The Growing Harms of Cross-Border Illicit Trade Vectors and Threat Convergence to Canada's National Security. If this doesn't get you thinking about our relationship with USA..... The depopulation exemption on ostriches is still in play although it might end and all due to PCR testing. Legit Climate change hysteria from MLA's in BC! And buckle up Canada - GFANZ is in play and USA is talking about it, in a Judicial Report. A sincere heads up from American oil rigs for Alberta to get their shit together quick Value for Value. You Canadian News deconstruction with zero ads. Please donate! Thanks for watching and listening. https://eh-list.ca/ Support the show directly: https://grimericacbd.com/ CBD and THC Tinctures and Gummies! https://grimerica.ca/support-2/ http://Grimerica.ca/shrooms and Micro Dosing The Eh-List YouTube Channel: https://youtube.com/@theeh-list?si=d_ThkEYAK6UG_hGX Our Adultbrain Audiobook Podcast and Website: www.adultbrain.ca Our Audiobook Youtube Channel: https://www.youtube.com/@adultbrainaudiobookpublishing/videos Support and extra content http://www.grimericaoutlawed.ca/support. Substack and Subscribe. https://grimericaoutlawed.substack.com/ or to our Locals https://grimericaoutlawed.locals.com/ or Rokfin www.Rokfin.com/Grimerica Patreon https://www.patreon.com/grimericaoutlawed Darren's book www.acanadianshame.ca Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com www.grimerica.ca/Shrooms and Micro-Dosing Other affiliated shows: www.grimerica.ca The OG Grimerica Show www.Rokfin.com/Grimerica Our channel on free speech Rokfin Join the chat / hangout with a bunch of fellow Grimericans Https://t.me.grimerica https://www.guilded.gg/chat/b7af7266-771d-427f-978c-872a7962a6c2?messageId=c1e1c7cd-c6e9-4eaf-abc9-e6ec0be89ff3 Leave a review on iTunes and/or Stitcher: https://itunes.apple.com/ca/podcast/grimerica-outlawed http://www.stitcher.com/podcast/grimerica-outlawed Sign up for our newsletter http://www.grimerica.ca/news SPAM Graham = and send him your synchronicities, feedback, strange experiences and psychedelic trip reports!! graham@grimerica.com InstaGRAM https://www.instagram.com/the_grimerica_show_podcast/ Purchase swag, with partial proceeds donated to the show www.grimerica.ca/swag Send us a postcard or letter http://www.grimerica.ca/contact/ ART - Napolean Duheme's site http://www.lostbreadcomic.com/ MUSIC Tru Northperception, Felix's Site sirfelix.bandcamp.com Links to the stuff we chatted about: https://www.ourgreaterdestiny.ca/p/icaie-report-colossal-scale-of-international?utm_source=post-email-title&publication_id=832740&post_id=159156905&utm_campaign=email-post-title&isFreemail=true&r=24pqe&triedRedirect=true&utm_medium=email https://lawyerlisa.substack.com/p/eu-plan-to-use-europeans-private?utm_source=post-email-title&publication_id=1287362&post_id=159342647&utm_campaign=email-post-title&isFreemail=true&r=24pqe&triedRedirect=true&utm_medium=email https://x.com/ryangerritsen/status/1901634358730973274 https://x.com/Ab51_Project/status/1901750010079060063 https://x.com/AnnRolle_/status/1901017931057623156 https://x.com/chrisdacey/status/1901595877942174100 https://x.com/FoodProfessor/status/1901436700670234704 https://x.com/cbcwatcher/status/1901353901141508126 https://x.com/Bob31685906/status/1901307197092737056 Darren's links: https://www.theepochtimes.com/opinion/quebec-is-replacing-multiculturalism-with-integration-english-canada-should-do-the-same-5823509?utm_source=OP_article_paid&src_src=OP_article_paid&utm_campaign=opinion-2025-03-19-ca&src_cmp=opinion-2025-03-19-ca&utm_medium=email&est=KsP4djGXC2jVUacDJOoMv7sk9QQWwcwin4XOeq3RN%2Ba7ash1%2FVgsX%2BR0P1ZhNwR6 https://x.com/sarbrajskahlon/status/1900594893065703658/photo/1 https://x.com/abdaniellesmith/status/1900672150530650457?s=43 https://x.com/cnm5000/status/1901295018201223573/photo/1 https://bcrising.ca/save-our-ostriches/ https://x.com/tablesalt13/status/1901317991783973313?s=43 https://x.com/thevivafrei/status/1902115262582632766/video/1
#1 Tired of the masks, lockdowns, and untested vaccines? Two fearless New Zealand physicians, Dr. Mark Bailey and Dr. Samantha Bailey, drsambailey.com, unleash their explosive book, The Final Pandemic: An Antidote to Medical Tyranny! They're ripping the veil off the so-called "settled science" of virology, exposing a century of lies about viruses and contagion that never held up to real scrutiny. From the Spanish Flu's failed transmission experiments to the common cold's laughable "virus hunts," they reveal how fear—not germs—has been the real contagion all along. Backed by 444 rock-solid references, this isn't conspiracy—it's science reclaiming its purpose#2 Christine Massey blows the lid off the global virus scam! Armed with Freedom of Information requests sent to 225 institutions across 40 countries, she relentlessly demanded one simple thing: proof that the SARS-CoV-2 virus—or any virus—was ever isolated from a sick person. The result? A deafening silence—no evidence, no particles, nothing but a house of cards built on CGI cartoons and fraudulent PCR tests! From the CDC to the FDA, health agencies worldwide confessed: they've got no proof, and virology's "science" is a sham. Discover how Christine's five-year crusade exposes the pandemic as a trillion-dollar lie, shattering the myth of contagion and empowering you to question everything. substack.com/@christinemasseyfois1 #3 Catherine Austin Fitts, solari.com, former HUD Assistant Secretary and financial whistleblower, unveils the chilling truth behind the DOGE operation! Far from a simple budget trim, she reveals a shadowy scheme—led by an "Elon Musk" operation, not just a man—to gut the civil service, shift billions to corporate cronies, and erect an AI-powered control grid that could enslave us all. With $38 billion already funneled to Musk's empire, vanishing trillions, and a Bitcoin Ponzi plot eyeing America's land, Fitts warns of a coup disguised as reform. And what of RFK Jr.'s jaw-dropping embrace of MMR that's left allies reeling and skeptics roaring? Once a champion of truth with Children's Health Defense, he's now under fire, squeezed by unseen forces in a brutal game of political chess and the plot to rebuild trust in a corrupt system. Is RFK a hero or a pawn in this high-stakes conspiracy?If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-show Or you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Money should have intrinsic value AND transactional privacy: Go to DavidKnight.gold for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to TrendsJournal.com and enter the code KNIGHTFor 10% off supplements and books, go to RNCstore.com and enter the code KNIGHTBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
#1 Tired of the masks, lockdowns, and untested vaccines? Two fearless New Zealand physicians, Dr. Mark Bailey and Dr. Samantha Bailey, drsambailey.com, unleash their explosive book, The Final Pandemic: An Antidote to Medical Tyranny! They're ripping the veil off the so-called "settled science" of virology, exposing a century of lies about viruses and contagion that never held up to real scrutiny. From the Spanish Flu's failed transmission experiments to the common cold's laughable "virus hunts," they reveal how fear—not germs—has been the real contagion all along. Backed by 444 rock-solid references, this isn't conspiracy—it's science reclaiming its purpose#2 Christine Massey blows the lid off the global virus scam! Armed with Freedom of Information requests sent to 225 institutions across 40 countries, she relentlessly demanded one simple thing: proof that the SARS-CoV-2 virus—or any virus—was ever isolated from a sick person. The result? A deafening silence—no evidence, no particles, nothing but a house of cards built on CGI cartoons and fraudulent PCR tests! From the CDC to the FDA, health agencies worldwide confessed: they've got no proof, and virology's "science" is a sham. Discover how Christine's five-year crusade exposes the pandemic as a trillion-dollar lie, shattering the myth of contagion and empowering you to question everything. substack.com/@christinemasseyfois1 #3 Catherine Austin Fitts, solari.com, former HUD Assistant Secretary and financial whistleblower, unveils the chilling truth behind the DOGE operation! Far from a simple budget trim, she reveals a shadowy scheme—led by an "Elon Musk" operation, not just a man—to gut the civil service, shift billions to corporate cronies, and erect an AI-powered control grid that could enslave us all. With $38 billion already funneled to Musk's empire, vanishing trillions, and a Bitcoin Ponzi plot eyeing America's land, Fitts warns of a coup disguised as reform. And what of RFK Jr.'s jaw-dropping embrace of MMR that's left allies reeling and skeptics roaring? Once a champion of truth with Children's Health Defense, he's now under fire, squeezed by unseen forces in a brutal game of political chess and the plot to rebuild trust in a corrupt system. Is RFK a hero or a pawn in this high-stakes conspiracy?If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-show Or you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Money should have intrinsic value AND transactional privacy: Go to DavidKnight.gold for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to TrendsJournal.com and enter the code KNIGHTFor 10% off supplements and books, go to RNCstore.com and enter the code KNIGHTBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
Trump's tariff chaos backfires hilariously—his own USMCA treaty, a NAFTA glow-up he once hyped, trips up his team, leaving Canada and Mexico untouchableThe FDA's sham “black box” warnings shield Big Pharma's as he kills and cripplesWikipedia's Larry Sanger flips the script, trading hardcore skepticism for unshakable faith in a brain-busting journey rivaling C.S. Lewis.A “measles death” hoax unravels—hospitals dodge blame for a girl's RSV demise, pushing dodgy tests and MMR agendasDOGE crashes as courts prove they can squash his cuts with a single gavel. Will Trump challenge judicial supremacy?2:30 Trump Tariffs Sabotaged by His Own Trade TreatyNo one in the Trump administration read the USMCA (NAFTA rebranded) treaty Trump was so proud of in his first administration. So the tariff pendulum swings back and forth. How much of goods from Canada & Mexico are off limits? Will anything change in 30 days? 24:11 Black Box Cover-Up: People Dead or Disabled as FDA & Pharma Shifts Blame to Physicians & Pharmacists A pharmaceutical scandal that's destroying lives—like Whistler's and 27-year-old Elisa's—with the dangerous drug Levofloxacin (aka Levaquin). Prescribed for pneumonia, it left Elisa trembling, crippled by nerve pain and joint agony, mirroring Whistler's nightmare. The FDA's "black box" warnings are a sick joke—buried, ignored, and never shared by doctors or pharmacists who shrug, "It's rare!” This is how Big Pharma poisons with impunity while the FDA—Free to Do Anything—rubber-stamps their crimes. 44:34 LIVE comments from audience 55:59 Wikipedia Mastermind Shocks the World: From Atheist Skeptic to Christian Convert Larry Sanger, co-founder Wikipedia, has a stunning embrace of Christianity! This isn't just another celebrity conversion—it's a PhD philosopher's epic showdown with faith, tearing through decades of skepticism like a intellectual bulldozer. Raised with unanswered questions Sanger dove into the Bible, not to believe, but to dissect it. What he found? Answers that rocked his Ayn Rand-loving, agnostic world! Compared to C.S. Lewis and cold-case detective J. Warner Wallace, his journey from doubt to truth is a wild ride of reason, fueled by marriage, fatherhood, and a relentless quest for meaning. Uncover the shocking twist that's got everyone talking—faith isn't blind, it's bulletproof 1:05:28 “Measles Death” Looks Like Hospital Murder & Misattribution Forget the headlines screaming “unvaccinated doom”—this little girl, battling RSV pneumonia, was allegedly denied breathing treatments while her desperate parents begged for help. No measles rash, just a dodgy PCR test, and now a second “death” pops up with the same shady story. This sinister agenda to peddle MMR shots and bully RFK Jr. into submission worked like a charm. They're even cooking up a “Gulf of Measles” scare for Spring Break, ignoring that college kids would be. It's not about health—it's a power grab1:30:19 Check Your Chicks for mRNA, and Check MAHA for Bird Flu Fearmongering If you're going to get spring chicks for your backyard make sure they're not vaccinated as Tractor Supply boasts! And make sure you're not supporting the “MAHA influencers” like McCullough who've shamelessly pivoted from truth-teller to fear-peddling shill, now pushing pandemic for profit1:45:21 Trump's DOGE Dream Crumbles: Courts Claw Back Billions as Judicial Supremacy Reigns!Pop the champagne? Not so fast! Unless Trump fights judicial supremacy none of the celebrated DOGE cuts will stick. Only one of 677 district judges can halt the parade whether it's probationary employees fired or USAID foreign aid cancelled. 2:03:10 Blackrock Bought Into Panama Canal Company About a Month After Trump's ElectionHmmm… 2:05:17 Trump's Wild Card Chaos: Gerald Celente Exposes the Billionaire Freak Show and Power GrabGerald Celente, trend-forecasting legend TrendsJournal.com, rips the mask off the Trump administration's unpredictable madness! From tariff whiplash to a billionaire-packed cabinet, the elites are cashing in while the world teeters on the edge of war and economic collapse. Trump steers Blackrock into the Panama Canal and China is overbuilt domestically and in other countries with the Belt & Road Initiative —trending toward a gold boomIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-show Or you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Money should have intrinsic value AND transactional privacy: Go to DavidKnight.gold for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to TrendsJournal.com and enter the code KNIGHTFor 10% off supplements and books, go to RNCstore.com and enter the code KNIGHTBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.
Trump's tariff chaos backfires hilariously—his own USMCA treaty, a NAFTA glow-up he once hyped, trips up his team, leaving Canada and Mexico untouchableThe FDA's sham “black box” warnings shield Big Pharma's as he kills and cripplesWikipedia's Larry Sanger flips the script, trading hardcore skepticism for unshakable faith in a brain-busting journey rivaling C.S. Lewis.A “measles death” hoax unravels—hospitals dodge blame for a girl's RSV demise, pushing dodgy tests and MMR agendasDOGE crashes as courts prove they can squash his cuts with a single gavel. Will Trump challenge judicial supremacy?2:30 Trump Tariffs Sabotaged by His Own Trade TreatyNo one in the Trump administration read the USMCA (NAFTA rebranded) treaty Trump was so proud of in his first administration. So the tariff pendulum swings back and forth. How much of goods from Canada & Mexico are off limits? Will anything change in 30 days? 24:11 Black Box Cover-Up: People Dead or Disabled as FDA & Pharma Shifts Blame to Physicians & Pharmacists A pharmaceutical scandal that's destroying lives—like Whistler's and 27-year-old Elisa's—with the dangerous drug Levofloxacin (aka Levaquin). Prescribed for pneumonia, it left Elisa trembling, crippled by nerve pain and joint agony, mirroring Whistler's nightmare. The FDA's "black box" warnings are a sick joke—buried, ignored, and never shared by doctors or pharmacists who shrug, "It's rare!” This is how Big Pharma poisons with impunity while the FDA—Free to Do Anything—rubber-stamps their crimes. 44:34 LIVE comments from audience 55:59 Wikipedia Mastermind Shocks the World: From Atheist Skeptic to Christian Convert Larry Sanger, co-founder Wikipedia, has a stunning embrace of Christianity! This isn't just another celebrity conversion—it's a PhD philosopher's epic showdown with faith, tearing through decades of skepticism like a intellectual bulldozer. Raised with unanswered questions Sanger dove into the Bible, not to believe, but to dissect it. What he found? Answers that rocked his Ayn Rand-loving, agnostic world! Compared to C.S. Lewis and cold-case detective J. Warner Wallace, his journey from doubt to truth is a wild ride of reason, fueled by marriage, fatherhood, and a relentless quest for meaning. Uncover the shocking twist that's got everyone talking—faith isn't blind, it's bulletproof 1:05:28 “Measles Death” Looks Like Hospital Murder & Misattribution Forget the headlines screaming “unvaccinated doom”—this little girl, battling RSV pneumonia, was allegedly denied breathing treatments while her desperate parents begged for help. No measles rash, just a dodgy PCR test, and now a second “death” pops up with the same shady story. This sinister agenda to peddle MMR shots and bully RFK Jr. into submission worked like a charm. They're even cooking up a “Gulf of Measles” scare for Spring Break, ignoring that college kids would be. It's not about health—it's a power grab1:30:19 Check Your Chicks for mRNA, and Check MAHA for Bird Flu Fearmongering If you're going to get spring chicks for your backyard make sure they're not vaccinated as Tractor Supply boasts! And make sure you're not supporting the “MAHA influencers” like McCullough who've shamelessly pivoted from truth-teller to fear-peddling shill, now pushing pandemic for profit1:45:21 Trump's DOGE Dream Crumbles: Courts Claw Back Billions as Judicial Supremacy Reigns!Pop the champagne? Not so fast! Unless Trump fights judicial supremacy none of the celebrated DOGE cuts will stick. Only one of 677 district judges can halt the parade whether it's probationary employees fired or USAID foreign aid cancelled. 2:03:10 Blackrock Bought Into Panama Canal Company About a Month After Trump's ElectionHmmm… 2:05:17 Trump's Wild Card Chaos: Gerald Celente Exposes the Billionaire Freak Show and Power GrabGerald Celente, trend-forecasting legend TrendsJournal.com, rips the mask off the Trump administration's unpredictable madness! From tariff whiplash to a billionaire-packed cabinet, the elites are cashing in while the world teeters on the edge of war and economic collapse. Trump steers Blackrock into the Panama Canal and China is overbuilt domestically and in other countries with the Belt & Road Initiative —trending toward a gold boomIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-show Or you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Money should have intrinsic value AND transactional privacy: Go to DavidKnight.gold for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to TrendsJournal.com and enter the code KNIGHTFor 10% off supplements and books, go to RNCstore.com and enter the code KNIGHTBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.
Dr. Gary Null provides a commentary on "Universal Healthcare" Universal Healthcare is the Solution to a Broken Medical System Gary Null, PhD Progressive Radio Network, March 3, 2025 For over 50 years, there has been no concerted or successful effort to bring down medical costs in the American healthcare system. Nor are the federal health agencies making disease prevention a priority. Regardless whether the political left or right sponsors proposals for reform, such measures are repeatedly defeated by both parties in Congress. As a result, the nation's healthcare system remains one of the most expensive and least efficient in the developed world. For the past 30 years, medical bills contributing to personal debt regularly rank among the top three causes of personal bankruptcy. This is a reality that reflects not only the financial strain on ordinary Americans but the systemic failure of the healthcare system itself. The urgent question is: If President Trump and his administration are truly seeking to reduce the nation's $36 trillion deficit, why is there no serious effort to reform the most bloated and corrupt sector of the economy? A key obstacle is the widespread misinformation campaign that falsely claims universal health care would cost an additional $2 trillion annually and further balloon the national debt. However, a more honest assessment reveals the opposite. If the US adopted a universal single-payer system, the nation could actually save up to $20 trillion over the next 10 years rather than add to the deficit. Even with the most ambitious efforts by people like Elon Musk to rein in federal spending or optimize government efficiency, the estimated savings would only amount to $500 billion. This is only a fraction of what could be achieved through comprehensive healthcare reform alone. Healthcare is the largest single expenditure of the federal budget. A careful examination of where the $5 trillion spent annually on healthcare actually goes reveals massive systemic fraud and inefficiency. Aside from emergency medicine, which accounts for only 10-12 percent of total healthcare expenditures, the bulk of this spending does not deliver better health outcomes nor reduce trends in physical and mental illness. Applying Ockham's Razor, the principle that the simplest solution is often the best, the obvious conclusion is that America's astronomical healthcare costs are the direct result of price gouging on an unimaginable scale. For example, in most small businesses, profit margins range between 1.6 and 2.5 percent, such as in grocery retail. Yet the pharmaceutical industrial complex routinely operates on markup rates as high as 150,000 percent for many prescription drugs. The chart below highlights the astronomical gap between the retail price of some top-selling patented pharmaceutical medications and their generic equivalents. Drug Condition Patent Price (per unit) Generic Price Estimated Manufacture Cost Markup Source Insulin (Humalog) Diabetes $300 $30 $3 10,000% Rand (2021) EpiPen Allergic reactions $600 $30 $10 6,000% BMJ (2022) Daraprim Toxoplasmosis $750/pill $2 $0.50 150,000% JAMA (2019) Harvoni Hepatitis C $94,500 (12 weeks) $30,000 $200 47,000% WHO Report (2018) Lipitor Cholesterol $150 $10 $0.50 29,900% Health Affairs (2020) Xarelto Blood Thinner $450 $25 $1.50 30,000% NEJM (2020) Abilify Schizophrenia $800 (30 tablets) $15 $2 39,900% AJMC (2019) Revlimid Cancer $16,000/mo $450 $150 10,500% Kaiser Health News (2021) Humira Arthritis $2,984/dose $400 $50 5,868% Rand (2021) Sovaldi Hepatitis C $1,000/pill $10 $2 49,900% JAMA (2021) Xolair Asthma $2,400/dose $300 $50 4,800% NEJM (2020) Gleevec Leukemia $10,000/mo $350 $200 4,900% Harvard Public Health Review (2020) OxyContin Pain Relief $600 (30 tablets) $15 $0.50 119,900% BMJ (2022) Remdesivir Covid-19 $3,120 (5 doses) N/A $10 31,100% The Lancet (2020) The corruption extends far beyond price gouging. Many pharmaceutical companies convince federal health agencies to fund their basic research and drug development with taxpayer dollars. Yet when these companies bring successful products to market, the profits are kept entirely by the corporations or shared with the agencies or groups of government scientists. On the other hand, the public, who funded the research, receives no financial return. This amounts to a systemic betrayal of the public trust on a scale of hundreds of billions of dollars annually. Another significant contributor to rising healthcare costs is the widespread practice of defensive medicine that is driven by the constant threat of litigation. Over the past 40 years, defensive medicine has become a cottage industry. Physicians order excessive diagnostic tests and unnecessary treatments simply to protect themselves from lawsuits. Study after study has shown that these over-performed procedures not only inflate costs but lead to iatrogenesis or medical injury and death caused by the medical system and practices itself. The solution is simple: adopting no-fault healthcare coverage for everyone where patients receive care without needing to sue and thereby freeing doctors from the burden of excessive malpractice insurance. A single-payer universal healthcare system could fundamentally transform the entire industry by capping profits at every level — from drug manufacturers to hospitals to medical equipment suppliers. The Department of Health and Human Services would have the authority to set profit margins for medical procedures. This would ensure that healthcare is determined by outcomes, not profits. Additionally, the growing influence of private equity firms and vulture capitalists buying up hospitals and medical clinics across America must be reined in. These equity firms prioritize profit extraction over improving the quality of care. They often slash staff, raise prices, and dictate medical procedures based on what will yield the highest returns. Another vital reform would be to provide free medical education for doctors and nurses in exchange for five years of service under the universal system. Medical professionals would earn a realistic salary cap to prevent them from being lured into equity partnerships or charging exorbitant rates. The biggest single expense in the current system, however, is the private health insurance industry, which consumes 33 percent of the $5 trillion healthcare budget. Health insurance CEOs consistently rank among the highest-paid executives in the country. Their companies, who are nothing more than bean counters, decide what procedures and drugs will be covered, partially covered, or denied altogether. This entire industry is designed to place profits above patients' lives. If the US dismantled its existing insurance-based system and replaced it with a fully reformed national healthcare model, the country could save $2.7 trillion annually while simultaneously improving health outcomes. Over the course of 10 years, those savings would amount to $27 trillion. This could wipe out nearly the entire national debt in a short time. This solution has been available for decades but has been systematically blocked by corporate lobbying and bipartisan corruption in Washington. The path forward is clear but only if American citizens demand a system where healthcare is valued as a public service and not a commodity. The national healthcare crisis is not just a fiscal issue. It is a crucial moral failure of the highest order. With the right reforms, the nation could simultaneously restore its financial health and deliver the kind of healthcare system its citizens have long deserved. American Healthcare: Corrupt, Broken and Lethal Richard Gale and Gary Null Progressive Radio Network, March 3, 2025 For a nation that prides itself on being the world's wealthiest, most innovative and technologically advanced, the US' healthcare system is nothing less than a disaster and disgrace. Not only are Americans the least healthy among the most developed nations, but the US' health system ranks dead last among high-income countries. Despite rising costs and our unshakeable faith in American medical exceptionalism, average life expectancy in the US has remained lower than other OECD nations for many years and continues to decline. The United Nations recognizes healthcare as a human right. In 2018, former UN Secretary General Ban Ki-moon denounced the American healthcare system as "politically and morally wrong." During the pandemic it is estimated that two to three years was lost on average life expectancy. On the other hand, before the Covid-19 pandemic, countries with universal healthcare coverage found their average life expectancy stable or slowly increasing. The fundamental problem in the U.S. is that politics have been far too beholden to the pharmaceutical, HMO and private insurance industries. Neither party has made any concerted effort to reign in the corruption of corporate campaign funding and do what is sensible, financially feasible and morally correct to improve Americans' quality of health and well-being. The fact that our healthcare system is horribly broken is proof that moneyed interests have become so powerful to keep single-payer debate out of the media spotlight and censored. Poll after poll shows that the American public favors the expansion of public health coverage. Other incremental proposals, including Medicare and Medicaid buy-in plans, are also widely preferred to the Affordable Care Act or Obamacare mess we are currently stuck with. It is not difficult to understand how the dismal state of American medicine is the result of a system that has been sold out to the free-market and the bottom line interests of drug makers and an inflated private insurance industry. How advanced and ethically sound can a healthcare system be if tens of millions of people have no access to medical care because it is financially out of their reach? The figures speak for themselves. The U.S. is burdened with a $41 trillion Medicare liability. The number of uninsured has declined during the past several years but still lingers around 25 million. An additional 30-35 million are underinsured. There are currently 65 million Medicare enrollees and 89 million Medicaid recipients. This is an extremely unhealthy snapshot of the country's ability to provide affordable healthcare and it is certainly unsustainable. The system is a public economic failure, benefiting no one except the large and increasingly consolidated insurance and pharmaceutical firms at the top that supervise the racket. Our political parties have wrestled with single-payer or universal healthcare for decades. Obama ran his first 2008 presidential campaign on a single-payer platform. Since 1985, his campaign health adviser, the late Dr. Quentin Young from the University of Illinois Medical School, was one of the nation's leading voices calling for universal health coverage. During a private conversation with Dr. Young shortly before his passing in 2016, he conveyed his sense of betrayal at the hands of the Obama administration. Dr. Young was in his 80s when he joined the Obama campaign team to help lead the young Senator to victory on a promise that America would finally catch up with other nations. The doctor sounded defeated. He shared how he was manipulated, and that Obama held no sincere intention to make universal healthcare a part of his administration's agenda. During the closed-door negotiations, which spawned the weak and compromised Affordable Care Act, Dr. Young was neither consulted nor invited to participate. In fact, he told us that he never heard from Obama again after his White House victory. Past efforts to even raise the issue have been viciously attacked. A huge army of private interests is determined to keep the public enslaved to private insurers and high medical costs. The failure of our healthcare is in no small measure due to it being a fully for-profit operation. Last year, private health insurance accounted for 65 percent of coverage. Consider that there are over 900 private insurance companies in the US. National Health Expenditures (NHE) grew to $4.5 trillion in 2022, which was 17.3 percent of GDP. Older corporate rank-and-file Democrats and Republicans argue that a single-payer or socialized medical program is unaffordable. However, not only is single-payer affordable, it will end bankruptcies due to unpayable medical debt. In addition, universal healthcare, structured on a preventative model, will reduce disease rates at the outset. Corporate Democrats argue that Obama's Affordable Care Act (ACA) was a positive step inching the country towards complete public coverage. However, aside from providing coverage to the poorest of Americans, Obamacare turned into another financial anchor around the necks of millions more. According to the health policy research group KFF, the average annual health insurance premium for single coverage is $8,400 and almost $24,000 for a family. In addition, patient out-of-pocket costs continue to increase, a 6.6% increase to $471 billion in 2022. Rather than healthcare spending falling, it has exploded, and the Trump and Biden administrations made matters worse. Clearly, a universal healthcare program will require flipping the script on the entire private insurance industry, which employed over half a million people last year. Obviously, the most volatile debate concerning a national universal healthcare system concerns cost. Although there is already a socialized healthcare system in place -- every federal legislator, bureaucrat, government employee and veteran benefits from it -- fiscal Republican conservatives and groups such as the Koch Brothers network are single-mindedly dedicated to preventing the expansion of Medicare and Medicaid. A Koch-funded Mercatus analysis made the outrageous claim that a single-payer system would increase federal health spending by $32 trillion in ten years. However, analyses and reviews by the Congressional Budget Office in the early 1990s concluded that such a system would only increase spending at the start; enormous savings would quickly offset it as the years pass. In one analysis, "the savings in administrative costs [10 percent of health spending] would be more than enough to offset the expense of universal coverage." Defenders of those advocating for funding a National Health Program argue this can primarily be accomplished by raising taxes to levels comparable to other developed nations. This was a platform Senator Bernie Sanders and some of the younger progressive Democrats in the House campaigned on. The strategy was to tax the highest multimillion-dollar earners 60-70 percent. Despite the outrage of its critics, including old rank-and-file multi-millionaire Democrats like Nancy Pelosi and Chuck Schumer, this is still far less than in the past. During the Korean War, the top tax rate was 91 percent; it declined to 70 percent in the late 1960s. Throughout most of the 1970s, those in the lowest income bracket were taxed at 14 percent. We are not advocating for this strategy because it ignores where the funding is going, and the corruption in the system that is contributing to exorbitant waste. But Democratic supporters of the ACA who oppose a universal healthcare plan ignore the additional taxes Obama levied to pay for the program. These included surtaxes on investment income, Medicare taxes from those earning over $200,000, taxes on tanning services, an excise tax on medical equipment, and a 40 percent tax on health coverage for costs over the designated cap that applied to flexible savings and health savings accounts. The entire ACA was reckless, sloppy and unnecessarily complicated from the start. The fact that Obamacare further strengthened the distinctions between two parallel systems -- federal and private -- with entirely different economic structures created a labyrinth of red tape, rules, and wasteful bureaucracy. Since the ACA went into effect, over 150 new boards, agencies and programs have had to be established to monitor its 2,700 pages of gibberish. A federal single-payer system would easily eliminate this bureaucracy and waste. A medical New Deal to establish universal healthcare coverage is a decisive step in the correct direction. But we must look at the crisis holistically and in a systematic way. Simply shuffling private insurance into a federal Medicare-for-all or buy-in program, funded by taxing the wealthiest of citizens, would only temporarily reduce costs. It will neither curtail nor slash escalating disease rates e. Any effective healthcare reform must also tackle the underlying reasons for Americans' poor state of health. We cannot shy away from examining the social illnesses infecting our entire free-market capitalist culture and its addiction to deregulation. A viable healthcare model would have to structurally transform how the medical economy operates. Finally, a successful medical New Deal must honestly evaluate the best and most reliable scientific evidence in order to effectively redirect public health spending. For example, Dr. Ezekiel Emanuel, a former Obama healthcare adviser, observed that AIDS-HIV measures consume the most public health spending, even though the disease "ranked 75th on the list of diseases by personal health expenditures." On the other hand, according to the American Medical Association, a large percentage of the nation's $3.4 trillion healthcare spending goes towards treating preventable diseases, notably diabetes, common forms of heart disease, and back and neck pain conditions. In 2016, these three conditions were the most costly and accounted for approximately $277 billion in spending. Last year, the CDC announced the autism rate is now 1 in 36 children compared to 1 in 44 two years ago. A retracted study by Mark Blaxill, an autism activist at the Holland Center and a friend of the authors, estimates that ASD costs will reach $589 billion annually by 2030. There are no signs that this alarming trend will reverse and decline; and yet, our entire federal health system has failed to conscientiously investigate the underlying causes of this epidemic. All explanations that might interfere with the pharmaceutical industry's unchecked growth, such as over-vaccination, are ignored and viciously discredited without any sound scientific evidence. Therefore, a proper medical New Deal will require a systemic overhaul and reform of our federal health agencies, especially the HHS, CDC and FDA. Only the Robert Kennedy Jr presidential campaign is even addressing the crisis and has an inexpensive and comprehensive plan to deal with it. For any medical revolution to succeed in advancing universal healthcare, the plan must prioritize spending in a manner that serves public health and not private interests. It will also require reshuffling private corporate interests and their lobbyists to the sidelines, away from any strategic planning, in order to break up the private interests' control over federal agencies and its revolving door policies. Aside from those who benefit from this medical corruption, the overwhelming majority of Americans would agree with this criticism. However, there is a complete lack of national trust that our legislators, including the so-called progressives, would be willing to undertake such actions. In addition, America's healthcare system ignores the single most critical initiative to reduce costs - that is, preventative efforts and programs instead of deregulation and closing loopholes designed to protect the drug and insurance industries' bottom line. Prevention can begin with banning toxic chemicals that are proven health hazards associated with current disease epidemics, and it can begin by removing a 1,000-plus toxins already banned in Europe. This should be a no-brainer for any legislator who cares for public health. For example, Stacy Malkan, co-founder of the Campaign for Safe Cosmetics, notes that "the policy approach in the US and Europe is dramatically different" when it comes to chemical allowances in cosmetic products. Whereas the EU has banned 1,328 toxic substances from the cosmetic industry alone, the US has banned only 11. The US continues to allow carcinogenic formaldehyde, petroleum, forever chemicals, many parabens (an estrogen mimicker and endocrine hormone destroyer), the highly allergenic p-phenylenediamine or PBD, triclosan, which has been associated with the rise in antibiotic resistant bacteria, avobenzone, and many others to be used in cosmetics, sunscreens, shampoo and hair dyes. Next, the food Americans consume can be reevaluated for its health benefits. There should be no hesitation to tax the unhealthiest foods, such as commercial junk food, sodas and candy relying on high fructose corn syrup, products that contain ingredients proven to be toxic, and meat products laden with dangerous chemicals including growth hormones and antibiotics. The scientific evidence that the average American diet is contributing to rising disease trends is indisputable. We could also implement additional taxes on the public advertising of these demonstrably unhealthy products. All such tax revenue would accrue to a national universal health program to offset medical expenditures associated with the very illnesses linked to these products. Although such tax measures would help pay for a new medical New Deal, it may be combined with programs to educate the public about healthy nutrition if it is to produce a reduction in the most common preventable diseases. In fact, comprehensive nutrition courses in medical schools should be mandatory because the average physician receives no education in this crucial subject. In addition, preventative health education should be mandatory throughout public school systems. Private insurers force hospitals, clinics and private physicians into financial corners, and this is contributing to prodigious waste in money and resources. Annually, healthcare spending towards medical liability insurance costs tens of billions of dollars. In particular, this economic burden has taxed small clinics and physicians. It is well past the time that physician liability insurance is replaced with no-fault options. Today's doctors are spending an inordinate amount of money to protect themselves. Legions of liability and trial lawyers seek big paydays for themselves stemming from physician error. This has created a culture of fear among doctors and hospitals, resulting in the overly cautious practice of defensive medicine, driving up costs and insurance premiums just to avoid lawsuits. Doctors are forced to order unnecessary tests and prescribe more medications and medical procedures just to cover their backsides. No-fault insurance is a common-sense plan that enables physicians to pursue their profession in a manner that will reduce iatrogenic injuries and costs. Individual cases requiring additional medical intervention and loss of income would still be compensated. This would generate huge savings. No other nation suffers from the scourge of excessive drug price gouging like the US. After many years of haggling to lower prices and increase access to generic drugs, only a minute amount of progress has been made in recent years. A 60 Minutes feature about the Affordable Care Act reported an "orgy of lobbying and backroom deals in which just about everyone with a stake in the $3-trillion-a-year health industry came out ahead—except the taxpayers.” For example, Life Extension magazine reported that an antiviral cream (acyclovir), which had lost its patent protection, "was being sold to pharmacies for 7,500% over the active ingredient cost. The active ingredient (acyclovir) costs only 8 pennies, yet pharmacies are paying a generic maker $600 for this drug and selling it to consumers for around $700." Other examples include the antibiotic Doxycycline. The price per pill averages 7 cents to $3.36 but has a 5,300 percent markup when it reaches the consumer. The antidepressant Clomipramine is marked up 3,780 percent, and the anti-hypertensive drug Captopril's mark-up is 2,850 percent. And these are generic drugs! Medication costs need to be dramatically cut to allow drug manufacturers a reasonable but not obscene profit margin. By capping profits approximately 100 percent above all costs, we would save our system hundreds of billions of dollars. Such a measure would also extirpate the growing corporate misdemeanors of pricing fraud, which forces patients to pay out-of-pocket in order to make up for the costs insurers are unwilling to pay. Finally, we can acknowledge that our healthcare is fundamentally a despotic rationing system based upon high insurance costs vis-a-vis a toss of the dice to determine where a person sits on the economic ladder. For the past three decades it has contributed to inequality. The present insurance-based economic metrics cast millions of Americans out of coverage because private insurance costs are beyond their means. Uwe Reinhardt, a Princeton University political economist, has called our system "brutal" because it "rations [people] out of the system." He defined rationing as "withholding something from someone that is beneficial." Discriminatory healthcare rationing now affects upwards to 60 million people who have been either priced out of the system or under insured. They make too much to qualify for Medicare under Obamacare, yet earn far too little to afford private insurance costs and premiums. In the final analysis, the entire system is discriminatory and predatory. However, we must be realistic. Almost every member of Congress has benefited from Big Pharma and private insurance lobbyists. The only way to begin to bring our healthcare program up to the level of a truly developed nation is to remove the drug industry's rampant and unnecessary profiteering from the equation. How did Fauci memory-hole a cure for AIDS and get away with it? By Helen Buyniski Over 700,000 Americans have died of AIDS since 1981, with the disease claiming some 42.3 million victims worldwide. While an HIV diagnosis is no longer considered a certain death sentence, the disease looms large in the public imagination and in public health funding, with contemporary treatments running into thousands of dollars per patient annually. But was there a cure for AIDS all this time - an affordable and safe treatment that was ruthlessly suppressed and attacked by the US public health bureaucracy and its agents? Could this have saved millions of lives and billions of dollars spent on AZT, ddI and failed HIV vaccine trials? What could possibly justify the decision to disappear a safe and effective approach down the memory hole? The inventor of the cure, Gary Null, already had several decades of experience creating healing protocols for physicians to help patients not responding well to conventional treatments by the time AIDS was officially defined in 1981. Null, a registered dietitian and board-certified nutritionist with a PhD in human nutrition and public health science, was a senior research fellow and Director of Anti-Aging Medicine at the Institute of Applied Biology for 36 years and has published over 950 papers, conducting groundbreaking experiments in reversing biological aging as confirmed with DNA methylation testing. Additionally, Null is a multi-award-winning documentary filmmaker, bestselling author, and investigative journalist whose work exposing crimes against humanity over the last 50 years has highlighted abuses by Big Pharma, the military-industrial complex, the financial industry, and the permanent government stay-behind networks that have come to be known as the Deep State. Null was contacted in 1974 by Dr. Stephen Caiazza, a physician working with a subculture of gay men in New York living the so-called “fast track” lifestyle, an extreme manifestation of the gay liberation movement that began with the Stonewall riots. Defined by rampant sexual promiscuity and copious use of illegal and prescription drugs, including heavy antibiotic use for a cornucopia of sexually-transmitted diseases, the fast-track never included more than about two percent of gay men, though these dominated many of the bathhouses and clubs that defined gay nightlife in the era. These patients had become seriously ill as a result of their indulgence, generally arriving at the clinic with multiple STDs including cytomegalovirus and several types of herpes and hepatitis, along with candida overgrowth, nutritional deficiencies, gut issues, and recurring pneumonia. Every week for the next 10 years, Null would counsel two or three of these men - a total of 800 patients - on how to detoxify their bodies and de-stress their lives, tracking their progress with Caiazza and the other providers at weekly feedback meetings that he credits with allowing the team to quickly evaluate which treatments were most effective. He observed that it only took about two years on the “fast track” for a healthy young person to begin seeing muscle loss and the recurrent, lingering opportunistic infections that would later come to be associated with AIDS - while those willing to commit to a healthier lifestyle could regain their health in about a year. It was with this background that Null established the Tri-State Healing Center in Manhattan in 1980, staffing the facility with what would eventually run to 22 certified health professionals to offer safe, natural, and effective low- and no-cost treatments to thousands of patients with HIV and AIDS-defining conditions. Null and his staff used variations of the protocols he had perfected with Caiazza's patients, a multifactorial patient-tailored approach that included high-dose vitamin C drips, intravenous ozone therapy, juicing and nutritional improvements and supplementation, aspects of homeopathy and naturopathy with some Traditional Chinese Medicine and Ayurvedic practices. Additional services offered on-site included acupuncture and holistic dentistry, while peer support groups were also held at the facility so that patients could find community and a positive environment, healing their minds and spirits while they healed their bodies. “Instead of trying to kill the virus with antiretroviral pharmaceuticals designed to stop viral replication before it kills patients, we focused on what benefits could be gained by building up the patients' natural immunity and restoring biochemical integrity so the body could fight for itself,” Null wrote in a 2014 article describing the philosophy behind the Center's approach, which was wholly at odds with the pharmaceutical model.1 Patients were comprehensively tested every week, with any “recovery” defined solely by the labs, which documented AIDS patient after patient - 1,200 of them - returning to good health and reversing their debilitating conditions. Null claims to have never lost an AIDS patient in the Center's care, even as the death toll for the disease - and its pharmaceutical standard of care AZT - reached an all-time high in the early 1990s. Eight patients who had opted for a more intensive course of treatment - visiting the Center six days a week rather than one - actually sero-deconverted, with repeated subsequent testing showing no trace of HIV in their bodies. As an experienced clinical researcher himself, Null recognized that any claims made by the Center would be massively scrutinized, challenging as they did the prevailing scientific consensus that AIDS was an incurable, terminal illness. He freely gave his protocols to any medical practitioner who asked, understanding that his own work could be considered scientifically valid only if others could replicate it under the same conditions. After weeks of daily observational visits to the Center, Dr. Robert Cathcart took the protocols back to San Francisco, where he excitedly reported that patients were no longer dying in his care. Null's own colleague at the Institute of Applied Biology, senior research fellow Elana Avram, set up IV drip rooms at the Institute and used his intensive protocols to sero-deconvert 10 patients over a two-year period. While the experiment had been conducted in secret, as the Institute had been funded by Big Pharma since its inception half a century earlier, Avram had hoped she would be able to publish a journal article to further publicize Null's protocols and potentially help AIDS patients, who were still dying at incredibly high rates thanks to Burroughs Wellcome's noxious but profitable AZT. But as she would later explain in a 2019 letter to Null, their groundbreaking research never made it into print - despite meticulous documentation of their successes - because the Institute's director and board feared their pharmaceutical benefactors would withdraw the funding on which they depended, given that Null's protocols did not involve any patentable or otherwise profitable drugs. When Avram approached them about publication, the board vetoed the idea, arguing that it would “draw negative attention because [the work] was contrary to standard drug treatments.” With no real point in continuing experiments along those lines without institutional support and no hope of obtaining funding from elsewhere, the department she had created specifically for these experiments shut down after a two-year followup with her test subjects - all of whom remained alive and healthy - was completed.2 While the Center was receiving regular visits by this time from medical professionals and, increasingly, black celebrities like Stokely Carmichael and Isaac Hayes, who would occasionally perform for the patients, the news was spreading by word of mouth alone - not a single media outlet had dared to document the clinic that was curing AIDS patients for free. Instead, they gave airtime to Anthony Fauci, director of the National Institute of Allergies and Infectious Diseases, who had for years been spreading baseless, hysteria-fueling claims about HIV and AIDS to any news outlet that would put him on. His claim that children could contract the virus from “ordinary household conduct” with an infected relative proved so outrageous he had to walk it back,3 and he never really stopped insisting the deadly plague associated with gays and drug users was about to explode like a nuclear bomb among the law-abiding heterosexual population. Fauci by this time controlled all government science funding through NIAID, and his zero-tolerance approach to dissent on the HIV/AIDS front had already seen prominent scientists like virologist Peter Duesberg stripped of the resources they needed for their work because they had dared to question his commandment: There is no cause of AIDS but HIV, and AZT is its treatment. Even the AIDS activist groups, which by then had been coopted by Big Pharma and essentially reduced to astroturfing for the toxic failed chemotherapy drug AZT backed by the institutional might of Fauci's NIAID,4 didn't seem to want to hear that there was a cure. Unconcerned with the irrationality of denouncing the man touting his free AIDS cure as an “AIDS denier,” they warned journalists that platforming Null or anyone else rejecting the mainstream medical line would be met with organized demands for their firing. Determined to breach the institutional iron curtain and get his message to the masses, Null and his team staged a press conference in New York, inviting scientists and doctors from around the world to share their research on alternative approaches to HIV and AIDS in 1993. To emphasize the sound scientific basis of the Center's protocols and encourage guests to adopt them into their own practices, Null printed out thousands of abstracts in support of each nutrient and treatment being used. However, despite over 7,000 invitations sent three times to major media, government figures, scientists, and activists, almost none of the intended audience members showed up. Over 100 AIDS patients and their doctors, whose charts exhaustively documented their improvements using natural and nontoxic modalities over the preceding 12 months, gave filmed testimonials, declaring that the feared disease was no longer a death sentence, but the conference had effectively been silenced. Bill Tatum, publisher of the Amsterdam News, suggested Null and his patients would find a more welcoming audience in his home neighborhood of Harlem - specifically, its iconic Apollo Theatre. For three nights, the theater was packed to capacity. Hit especially hard by the epidemic and distrustful of a medical system that had only recently stopped being openly racist (the Tuskegee syphilis experiment only ended in 1972), black Americans, at least, did not seem to care what Anthony Fauci would do if he found out they were investigating alternatives to AZT and death. PBS journalist Tony Brown, having obtained a copy of the video of patient testimonials from the failed press conference, was among a handful of black journalists who began visiting the Center to investigate the legitimacy of Null's claims. Satisfied they had something significant to offer his audience, Brown invited eight patients - along with Null himself - onto his program over the course of several episodes to discuss the work. It was the first time these protocols had received any attention in the media, despite Null having released nearly two dozen articles and multiple documentaries on the subject by that time. A typical patient on one program, Al, a recovered IV drug user who was diagnosed with AIDS at age 32, described how he “panicked,” saw a doctor and started taking AZT despite his misgivings - only to be forced to discontinue the drug after just a few weeks due to his condition deteriorating rapidly. Researching alternatives brought him to Null, and after six months of “detoxing [his] lifestyle,” he observed his initial symptoms - swollen lymph nodes and weight loss - begin to reverse, culminating with sero-deconversion. On Bill McCreary's Channel 5 program, a married couple diagnosed with HIV described how they watched their T-cell counts increase as they cut out sugar, caffeine, smoking, and drinking and began eating a healthy diet. They also saw the virus leave their bodies. For HIV-positive viewers surrounded by fear and negativity, watching healthy-looking, cheerful “AIDS patients” detail their recovery while Null backed up their claims with charts must have been balm for the soul. But the TV programs were also a form of outreach to the medical community, with patients' charts always on hand to convince skeptics the cure was scientifically valid. Null brought patients' charts to every program, urging them to keep an open mind: “Other physicians and public health officials should know that there's good science in the alternative perspective. It may not be a therapy that they're familiar with, because they're just not trained in it, but if the results are positive, and you can document them…” He challenged doubters to send in charts from their own sero-deconverted patients on AZT, and volunteered to debate proponents of the orthodox treatment paradigm - though the NIH and WHO both refused to participate in such a debate on Tony Brown's Journal, following Fauci's directive prohibiting engagement with forbidden ideas. Aside from those few TV programs and Null's own films, suppression of Null's AIDS cure beyond word of mouth was total. The 2021 documentary The Cost of Denial, produced by the Society for Independent Journalists, tells the story of the Tri-State Healing Center and the medical paradigm that sought to destroy it, lamenting the loss of the lives that might have been saved in a more enlightened society. Nurse practitioner Luanne Pennesi, who treated many of the AIDS patients at the Center, speculated in the film that the refusal by the scientific establishment and AIDS activists to accept their successes was financially motivated. “It was as if they didn't want this information to get out. Understand that our healthcare system as we know it is a corporation, it's a corporate model, and it's about generating revenue. My concern was that maybe they couldn't generate enough revenue from these natural approaches.”5 Funding was certainly the main disciplinary tool Fauci's NIAID used to keep the scientific community in line. Despite the massive community interest in the work being done at the Center, no foundation or institution would defy Fauci and risk getting itself blacklisted, leaving Null to continue funding the operation out of his pocket with the profits from book sales. After 15 years, he left the Center in 1995, convinced the mainstream model had so thoroughly been institutionalized that there was no chance of overthrowing it. He has continued to counsel patients and advocate for a reappraisal of the HIV=AIDS hypothesis and its pharmaceutical treatments, highlighting the deeply flawed science underpinning the model of the disease espoused by the scientific establishment in 39 articles, six documentaries and a 700-page textbook on AIDS, but the Center's achievements have been effectively memory-holed by Fauci's multi-billion-dollar propaganda apparatus. FRUIT OF THE POISONOUS TREE To understand just how much of a threat Null's work was to the HIV/AIDS establishment, it is instructive to revisit the 1984 paper, published by Dr. Robert Gallo of the National Cancer Institute, that established HIV as the sole cause of AIDS. The CDC's official recognition of AIDS in 1981 had done little to quell the mounting public panic over the mysterious illness afflicting gay men in the US, as the agency had effectively admitted it had no idea what was causing them to sicken and die. As years passed with no progress determining the causative agent of the plague, activist groups like Gay Men's Health Crisis disrupted public events and threatened further mass civil disobedience as they excoriated the NIH for its sluggish allocation of government science funding to uncovering the cause of the “gay cancer.”6 When Gallo published his paper declaring that the retrovirus we now know as HIV was the sole “probable” cause of AIDS, its simple, single-factor hypothesis was the answer to the scientific establishment's prayers. This was particularly true for Fauci, as the NIAID chief was able to claim the hot new disease as his agency's own domain in what has been described as a “dramatic confrontation” with his rival Sam Broder at the National Cancer Institute. After all, Fauci pointed out, Gallo's findings - presented by Health and Human Services Secretary Margaret Heckler as if they were gospel truth before any other scientists had had a chance to inspect them, never mind conduct a full peer review - clearly classified AIDS as an infectious disease, and not a cancer like the Kaposi's sarcoma which was at the time its most visible manifestation. Money and media attention began pouring in, even as funding for the investigation of other potential causes of AIDS dried up. Having already patented a diagnostic test for “his” retrovirus before introducing it to the world, Gallo was poised for a financial windfall, while Fauci was busily leveraging the discovery into full bureaucratic empire of the US scientific apparatus. While it would serve as the sole basis for all US government-backed AIDS research to follow - quickly turning Gallo into the most-cited scientist in the world during the 1980s,7 Gallo's “discovery” of HIV was deeply problematic. The sample that yielded the momentous discovery actually belonged to Prof. Luc Montagnier of the French Institut Pasteur, a fact Gallo finally admitted in 1991, four years after a lawsuit from the French government challenged his patent on the HIV antibody test, forcing the US government to negotiate a hasty profit-sharing agreement between Gallo's and Montagnier's labs. That lawsuit triggered a cascade of official investigations into scientific misconduct by Gallo, and evidence submitted during one of these probes, unearthed in 2008 by journalist Janine Roberts, revealed a much deeper problem with the seminal “discovery.” While Gallo's co-author, Mikulas Popovic, had concluded after numerous experiments with the French samples that the virus they contained was not the cause of AIDS, Gallo had drastically altered the paper's conclusion, scribbling his notes in the margins, and submitted it for publication to the journal Science without informing his co-author. After Roberts shared her discovery with contacts in the scientific community, 37 scientific experts wrote to the journal demanding that Gallo's career-defining HIV paper be retracted from Science for lacking scientific integrity.8 Their call, backed by an endorsement from the 2,600-member scientific organization Rethinking AIDS, was ignored by the publication and by the rest of mainstream science despite - or perhaps because of - its profound implications. That 2008 letter, addressed to Science editor-in-chief Bruce Alberts and copied to American Association for the Advancement of Science CEO Alan Leshner, is worth reproducing here in its entirety, as it utterly dismantles Gallo's hypothesis - and with them the entire HIV is the sole cause of AIDS dogma upon which the contemporary medical model of the disease rests: On May 4, 1984 your journal published four papers by a group led by Dr. Robert Gallo. We are writing to express our serious concerns with regard to the integrity and veracity of the lead paper among these four of which Dr. Mikulas Popovic is the lead author.[1] The other three are also of concern because they rely upon the conclusions of the lead paper .[2][3][4] In the early 1990s, several highly critical reports on the research underlying these papers were produced as a result of governmental inquiries working under the supervision of scientists nominated by the National Academy of Sciences and the Institute of Medicine. The Office of Research Integrity of the US Department of Health and Human Services concluded that the lead paper was “fraught with false and erroneous statements,” and that the “ORI believes that the careless and unacceptable keeping of research records...reflects irresponsible laboratory management that has permanently impaired the ability to retrace the important steps taken.”[5] Further, a Congressional Subcommittee on Oversight and Investigations led by US Representative John D. Dingell of Michigan produced a staff report on the papers which contains scathing criticisms of their integrity.[6] Despite the publically available record of challenges to their veracity, these papers have remained uncorrected and continue to be part of the scientific record. What prompts our communication today is the recent revelation of an astonishing number of previously unreported deletions and unjustified alterations made by Gallo to the lead paper. There are several documents originating from Gallo's laboratory that, while available for some time, have only recently been fully analyzed. These include a draft of the lead paper typewritten by Popovic which contains handwritten changes made to it by Gallo.[7] This draft was the key evidence used in the above described inquiries to establish that Gallo had concealed his laboratory's use of a cell culture sample (known as LAV) which it received from the Institut Pasteur. These earlier inquiries verified that the typed manuscript draft was produced by Popovic who had carried out the recorded experiment while his laboratory chief, Gallo, was in Europe and that, upon his return, Gallo changed the document by hand a few days before it was submitted to Science on March 30, 1984. According to the ORI investigation, “Dr. Gallo systematically rewrote the manuscript for what would become a renowned LTCB [Gallo's laboratory at the National Cancer Institute] paper.”[5] This document provided the important evidence that established the basis for awarding Dr. Luc Montagnier and Dr. Francoise Barré-Sinoussi the 2008 Nobel Prize in Medicine for the discovery of the AIDS virus by proving it was their samples of LAV that Popovic used in his key experiment. The draft reveals that Popovic had forthrightly admitted using the French samples of LAV renamed as Gallo's virus, HTLV-III, and that Gallo had deleted this admission, concealing their use of LAV. However, it has not been previously reported that on page three of this same document Gallo had also deleted Popovic's unambiguous statement that, "Despite intensive research efforts, the causative agent of AIDS has not yet been identified,” replacing it in the published paper with a statement that said practically the opposite, namely, “That a retrovirus of the HTLV family might be an etiologic agent of AIDS was suggested by the findings.” It is clear that the rest of Popovic's typed paper is entirely consistent with his statement that the cause of AIDS had not been found, despite his use of the French LAV. Popovic's final conclusion was that the culture he produced “provides the possibility” for detailed studies. He claimed to have achieved nothing more. At no point in his paper did Popovic attempt to prove that any virus caused AIDS, and it is evident that Gallo concealed these key elements in Popovic's experimental findings. It is astonishing now to discover these unreported changes to such a seminal document. We can only assume that Gallo's alterations of Popovic's conclusions were not highlighted by earlier inquiries because the focus at the time was on establishing that the sample used by Gallo's lab came from Montagnier and was not independently collected by Gallo. In fact, the only attention paid to the deletions made by Gallo pertains to his effort to hide the identity of the sample. The questions of whether Gallo and Popovic's research proved that LAV or any other virus was the cause of AIDS were clearly not considered. Related to these questions are other long overlooked documents that merit your attention. One of these is a letter from Dr. Matthew A. Gonda, then Head of the Electron Microscopy Laboratory at the National Cancer Institute, which is addressed to Popovic, copied to Gallo and dated just four days prior to Gallo's submission to Science.[8] In this letter, Gonda remarks on samples he had been sent for imaging because “Dr Gallo wanted these micrographs for publication because they contain HTLV.” He states, “I do not believe any of the particles photographed are of HTLV-I, II or III.” According to Gonda, one sample contained cellular debris, while another had no particles near the size of a retrovirus. Despite Gonda's clearly worded statement, Science published on May 4, 1984 papers attributed to Gallo et al with micrographs attributed to Gonda and described unequivocally as HTLV-III. In another letter by Gallo, dated one day before he submitted his papers to Science, Gallo states, “It's extremely rare to find fresh cells [from AIDS patients] expressing the virus... cell culture seems to be necessary to induce virus,” a statement which raises the possibility he was working with a laboratory artifact. [9] Included here are copies of these documents and links to the same. The very serious flaws they reveal in the preparation of the lead paper published in your journal in 1984 prompts our request that this paper be withdrawn. It appears that key experimental findings have been concealed. We further request that the three associated papers published on the same date also be withdrawn as they depend on the accuracy of this paper. For the scientific record to be reliable, it is vital that papers shown to be flawed, or falsified be retracted. Because a very public record now exists showing that the Gallo papers drew unjustified conclusions, their withdrawal from Science is all the more important to maintain integrity. Future researchers must also understand they cannot rely on the 1984 Gallo papers for statements about HIV and AIDS, and all authors of papers that previously relied on this set of four papers should have the opportunity to consider whether their own conclusions are weakened by these revelations. Gallo's handwritten revision, submitted without his colleague's knowledge despite multiple experiments that failed to support the new conclusion, was the sole foundation for the HIV=AIDS hypothesis. Had Science published the manuscript the way Popovic had typed it, there would be no AIDS “pandemic” - merely small clusters of people with AIDS. Without a viral hypothesis backing the development of expensive and deadly pharmaceuticals, would Fauci have allowed these patients to learn about the cure that existed all along? Faced with a potential rebellion, Fauci marshaled the full resources under his control to squelch the publication of the investigations into Gallo and restrict any discussion of competing hypotheses in the scientific and mainstream press, which had been running virus-scare stories full-time since 1984. The effect was total, according to biochemist Dr. Kary Mullis, inventor of the polymerase chain reaction (PCR) procedure. In a 2009 interview, Mullis recalled his own shock when he attempted to unearth the experimental basis for the HIV=AIDS hypothesis. Despite his extensive inquiry into the literature, “there wasn't a scientific reference…[that] said ‘here's how come we know that HIV is the probable cause of AIDS.' There was nothing out there like that.”9 This yawning void at the core of HIV/AIDS “science" turned him into a strident critic of AIDS dogma - and those views made him persona non grata where the scientific press was concerned, suddenly unable to publish a single paper despite having won the Nobel Prize for his invention of the PCR test just weeks before. 10 DISSENT BECOMES “DENIAL” While many of those who dissent from the orthodox HIV=AIDS view believe HIV plays a role in the development of AIDS, they point to lifestyle and other co-factors as being equally if not more important. Individuals who test positive for HIV can live for decades in perfect health - so long as they don't take AZT or the other toxic antivirals fast-tracked by Fauci's NIAID - but those who developed full-blown AIDS generally engaged in highly risky behaviors like extreme promiscuity and prodigious drug abuse, contracting STDs they took large quantities of antibiotics to treat, further running down their immune systems. While AIDS was largely portrayed as a “gay disease,” it was only the “fast track” gays, hooking up with dozens of partners nightly in sex marathons fueled by “poppers” (nitrate inhalants notorious for their own devastating effects on the immune system), who became sick. Kaposi's sarcoma, one of the original AIDS-defining conditions, was widespread among poppers-using gay men, but never appeared among IV drug users or hemophiliacs, the other two main risk groups during the early years of the epidemic. Even Robert Gallo himself, at a 1994 conference on poppers held by the National Institute on Drug Abuse, would admit that the previously-rare form of skin cancer surging among gay men was not primarily caused by HIV - and that it was immune stimulation, rather than suppression, that was likely responsible.11 Similarly, IV drug users are often riddled with opportunistic infections as their habit depresses the immune system and their focus on maintaining their addiction means that healthier habits - like good nutrition and even basic hygiene - fall by the wayside. Supporting the call for revising the HIV=AIDS hypothesis to include co-factors is the fact that the mass heterosexual outbreaks long predicted by Fauci and his ilk in seemingly every country on Earth have failed to materialize, except - supposedly - in Africa, where the diagnostic standard for AIDS differs dramatically from those of the West. Given the prohibitively high cost of HIV testing for poor African nations, the WHO in 1985 crafted a diagnostic loophole that became known as the “Bangui definition,” allowing medical professionals to diagnose AIDS in the absence of a test using just clinical symptoms: high fever, persistent cough, at least 30 days of diarrhea, and the loss of 10% of one's body weight within two months. Often suffering from malnutrition and without access to clean drinking water, many of the inhabitants of sub-Saharan Africa fit the bill, especially when the WHO added tuberculosis to the list of AIDS-defining illnesses in 1993 - a move which may be responsible for as many as one half of African “AIDS” cases, according to journalist Christine Johnson. The WHO's former Chief of Global HIV Surveillance, James Chin, acknowledged their manipulation of statistics, but stressed that it was the entire AIDS industry - not just his organization - perpetrating the fraud. “There's the saying that, if you knew what sausages are made of, most people would hesitate to sort of eat them, because they wouldn't like what's in it. And if you knew how HIV/AIDS numbers are cooked, or made up, you would use them with extreme caution,” Chin told an interviewer in 2009.12 With infected numbers stubbornly remaining constant in the US despite Fauci's fearmongering projections of the looming heterosexually-transmitted plague, the CDC in 1993 broadened its definition of AIDS to include asymptomatic (that is, healthy) HIV-positive people with low T-cell counts - an absurd criteria given that an individual's T-cell count can fluctuate by hundreds within a single day. As a result, the number of “AIDS cases” in the US immediately doubled. Supervised by Fauci, the NIAID had been quietly piling on diseases into the “AIDS-related” category for years, bloating the list from just two conditions - pneumocystis carinii pneumonia and Kaposi's sarcoma - to 30 so fast it raised eyebrows among some of science's leading lights. Deeming the entire process “bizarre” and unprecedented, Kary Mullis wondered aloud why no one had called the AIDS establishment out: “There's something wrong here. And it's got to be financial.”13 Indeed, an early CDC public relations campaign was exposed by the Wall Street Journal in 1987 as having deliberately mischaracterized AIDS as a threat to the entire population so as to garner increased public and private funding for what was very much a niche issue, with the risk to average heterosexuals from a single act of sex “smaller than the risk of ever getting hit by lightning.” Ironically, the ads, which sought to humanize AIDS patients in an era when few Americans knew anyone with the disease and more than half the adult population thought infected people should be forced to carry cards warning of their status, could be seen as a reaction to the fear tactics deployed by Fauci early on.14 It's hard to tell where fraud ends and incompetence begins with Gallo's HIV antibody test. Much like Covid-19 would become a “pandemic of testing,” with murder victims and motorcycle crashes lumped into “Covid deaths” thanks to over-sensitized PCR tests that yielded as many as 90% false positives,15 HIV testing is fraught with false positives - and unlike with Covid-19, most people who hear they are HIV-positive still believe they are receiving a death sentence. Due to the difficulty of isolating HIV itself from human samples, the most common diagnostic tests, ELISA and the Western Blot, are designed to detect not the virus but antibodies to it, upending the traditional medical understanding that the presence of antibodies indicates only exposure - and often that the body has actually vanquished the pathogen. Patients are known to test positive for HIV antibodies in the absence of the virus due to at least 70 other conditions, including hepatitis, lupus, rheumatoid arthritis, syphilis, recent vaccination or even pregnancy. (https://www.chcfl.org/diseases-that-can-cause-a-false-positive-hiv-test/) Positive results are often followed up with a PCR “viral load” test, even though the inventor of the PCR technique Kary Mullis famously condemned its misuse as a tool for diagnosing infection. Packaging inserts for all three tests warn the user that they cannot be reliably used to diagnose HIV.16 The ELISA HIV antibody test explicitly states: “At present there is no recognized standard for establishing the presence and absence of HIV antibody in human blood.”17 That the public remains largely unaware of these and other massive holes in the supposedly airtight HIV=AIDS=DEATH paradigm is a testament to Fauci's multi-layered control of the press. Like the writers of the Great Barrington Declaration and other Covid-19 dissidents, scientists who question HIV/AIDS dogma have been brutally punished for their heresy, no matter how prestigious their prior standing in the field and no matter how much evidence they have for their own claims. In 1987, the year the FDA's approval of AZT made AIDS the most profitable epidemic yet (a dubious designation Covid-19 has since surpassed), Fauci made it clearer than ever that scientific inquiry and debate - the basis of the scientific method - would no longer be welcome in the American public health sector, eliminating retrovirologist Peter Duesberg, then one of the most prominent opponents of the HIV=AIDS hypothesis, from the scientific conversation with a professional disemboweling that would make a cartel hitman blush. Duesberg had just eviscerated Gallo's 1984 HIV paper with an article of his own in the journal Cancer Research, pointing out that retroviruses had never before been found to cause a single disease in humans - let alone 30 AIDS-defining diseases. Rather than allow Gallo or any of the other scientists in his camp to respond to the challenge, Fauci waged a scorched-earth campaign against Duesberg, who had until then been one of the most highly regarded researchers in his field. Every research grant he requested was denied; every media appearance was canceled or preempted. The University of California at Berkeley, unable to fully fire him due to tenure, took away his lab, his graduate students, and the rest of his funding. The few colleagues who dared speak up for him in public were also attacked, while enemies and opportunists were encouraged to slander Duesberg at the conferences he was barred from attending and in the journals that would no longer publish his replies. When Duesberg was summoned to the White House later that year by then-President Ronald Reagan to debate Fauci on the origins of AIDS, Fauci convinced the president to cancel, allegedly pulling rank on the Commander-in-Chief with an accusation that the “White House was interfering in scientific matters that belonged to the NIH and the Office of Science and Technology Assessment.” After seven years of this treatment, Duesberg was contacted by NIH official Stephen O'Brien and offered an escape from professional purgatory. He could have “everything back,” he was told, and shown a manuscript of a scientific paper - apparently commissioned by the editor of the journal Nature - “HIV Causes AIDS: Koch's Postulates Fulfilled” with his own name listed alongside O'Brien's as an author.18 His refusal to take the bribe effectively guaranteed the epithet “AIDS denier” will appear on his tombstone. The character assassination of Duesberg became a template that would be deployed to great effectiveness wherever Fauci encountered dissent - never debate, only demonize, deplatform and destroy. Even Luc Montagnier, the real discoverer of HIV, soon found himself on the wrong side of the Fauci machine. With his 1990 declaration that “the HIV virus [by itself] is harmless and passive, a benign virus,” Montagnier began distancing himself from Gallo's fraud, effectively placing a target on his own back. In a 1995 interview, he elaborated: “four factors that have come together to account for the sudden epidemic [of AIDS]: HIV presence, immune hyper-activation, increased sexually transmitted disease incidence, sexual behavior changes and other behavioral changes” such as drug use, poor nutrition and stress - all of which he said had to occur “essentially simultaneously” for HIV to be transmitted, creating the modern epidemic. Like the professionals at the Tri-State Healing Center, Montagnier advocated for the use of antioxidants like vitamin C and N-acetyl cysteine, naming oxidative stress as a critical factor in the progression from HIV to AIDS.19 When Montagnier died in 2022, Fauci's media mouthpieces sneered that the scientist (who was awarded the Nobel Prize in 2008 for his discovery of HIV, despite his flagging faith in that discovery's significance) “started espousing views devoid of a scientific basis” in the late 2000s, leading him to be “shunned by the scientific community.”20 In a particularly egregious jab, the Washington Post's obit sings the praises of Robert Gallo, implying it was the American scientist who really should have won the Nobel for HIV, while dismissing as “
Culvitvate Elevate's Matt Roeske, a health educator, blows our minds in this one by taking down much of the conventional wisdom around DNA and PCR testing, and even challenges some of the red pill stances we've perhaps taken for granted, including the parasite model of illness, and the efficacy of Ivermectin. Grab your copy of the 2nd issue of the Chaos Twins now and join the Army Of Chaos: https://bit.ly/415fDfY Check out Sam "DoomScrollin with Sam Tripoli and Midnight Mike" Every Tuesday At 2:30pm pst on Youtube, X Twitter, Rumble and Rokfin! Join the WolfPack at Wise Wolf Gold and Silver and start hedging your financial position by investing in precious metals now! Go to samtripoli.gold and use the promo code "TinFoil" and we thank Tony for supporting our show. CopyMyCrypto.com: The ‘Copy my Crypto' membership site shows you the coins that the youtuber ‘James McMahon' personally holds - and allows you to copy him. 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What's really behind the price and scarcity of eggs? Today, I'm going to interview Clayton Baker, M.D. to discuss the recent bird flu outbreak. Egg prices are not random, and the outbreak is not an accident! DATA:https://brownstone.org/articles/bird-...Please join me in welcoming Dr. Clayton Baker! Dr. Baker points out the similarities between the current bird flu outbreak and the COVID-19 outbreak of 2020. The media creates fear, followed by a pandemic, to gain control. This eventually leads to civil rights violations, including lockdowns and work bans.Next, people are coerced into taking profitable yet toxic vaccines as a countermeasure against the outbreak. We are witnessing this once again with the current bird flu outbreak.There are two labs in the US: the Southeast Poultry Research Lab, funded by the USDA, and the University of Wisconsin Veterinary School, which conducts gain-of-function research on viruses. This involves manipulating a naturally occurring virus to make it more deadly and able to jump from species to species. Farmers are encouraged to perform PCR tests on their flocks, which are known for false positives. If any of their birds test positive for bird flu, they are paid to slaughter their entire flock. The increase in egg prices is not due to bird deaths from bird flu but rather the mass slaughter of birds. Over 1.25 billion taxpayer dollars have been used to fund this mass slaughter. Ultimately, the goal is to mass vaccinate chickens in the food supply against bird flu.Gain-of-function research is dangerous and must stop! We can also help combat this problem by purchasing eggs from smaller farmers at farmer's markets.
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