Eyla Cuenca has lived and traveled throughout the United States and several countries, accumulating knowledge and expertise in her field that spans over a decade. Her work strives to connect women, parents, and children through the scope of conception, birth and parenting. As a Birth Guide, she draws on a blend of ancient traditions and evidence based information to bring custom tailored support to every individual no matter where they are in their process. As a teacher, birth guide, and visual storyteller Eyla, offers Natural Birth classes, Prenatal and Postpartum Guidance Consultations, Reiki Energy healing, Documentary Birth Photography and highly individualized Birth Doula Support. She provides support in person and online so that anyone anywhere in the world has the opportunity for empowered birth education and guidance. Check out Eyla's course, Uncovering Birth, here What student get from the Uncovering Birth Immersion: a deep knowledge how labor and birth work fears transmuted into desires and courage Nutrition to avoid birth complications & support postpartum health effective non-chemical relaxation techniques clear understanding of breastfeeding, newborn care, postpartum healing tools for clear communication with medical providers & birth team a comprehensive unique birth & postpartum plan how to navigate variables & unexpected scenarios deeper connection and communication with your birth partner PDF's, Videos, and actions steps to support you in continued learning & conscious parenting “Maybe you want a natural birth but everyone says it's painful, and maybe even impossible. This 8 week deep dive into an empowered birth will crush your limiting beliefs holding you back from having the experience you want and are worthy of.” I get it, there is a lot telling us we can't do it. Telling us that birth is something we should want to get through as quickly as possible. I'm here to tell you, birth can be transformative, pleasurable and the best experience of your life. It's just a matter of getting fully informed. Are you ready to break through limiting beliefs and have a peaceful & empowered experience? ~Results of Taking this Course~ As a mother, after this course you will: Know how to prepare your body and mind for easeful and connected birthing Feel confident about your birth choices & making informed decisions Be able to plan and accomplish the natural birth of your dreams Understand how to welcome, nurture and care for your new baby Break through any fear or apprehensions about the “pain” or mysteries of birth As a father, after this course you will: Know exactly how to support the mother through her journey Feel confident in creating a masculine container within the birth context Be able to advocate more easily for your family Have the practical tools to read labor and assist with newborn care and postpartum support Dispel limiting beliefs about birth Check out Eyla's course, Uncovering Birth, here
Increasingly, LinkedIn is a crucial part of the hiring process. Whether employers are vetting you for a position you've applied for or seeking out candidates with the credentials they require, they ARE most definitely looking at your LI profile. Today, we're specifically covering strategies for writing an outstanding LI headline. This is the “tag line” that goes directly underneath your name at the top of your profile – and it is prime real estate. A reminder that I offer a monthly job search Masterclass, held on the third Thursday of the month at 4:00 p.m. Eastern. The topic is different each month, and I jam-pack them full of content. To learn about the next webinar: https://mastercoachwebinars.carrd.com1. Don't use the default.One of the biggest errors you can make on your LI headline is allowing LI to default to your current job title and employer. You have 220 characters to create a compelling headline; don't waste it. I'll be going over how best to leverage these 220 characters in this episode. 2. What are we trying to communicate in the headline? Your LI headline should communicate the following: -Who you are (your current or aspirational title, or the essence of your work) -What you do (How you add value to an organization)-Results you've produced (The results of the value you've added)-Credibility or proof (Evidence of what you've said about yourself) 3. Have a headline strategy in mind. For example: -If your current job title is the same job title you are job searching for, then start with that title | Your value proposition or keywords Example:Human Resources Manager | Delivering transformational leadership as a strategic partner | Proactively addressing issues and developing processes that solve complex business problems and enhance bottom-line results (213 characters) With Keywords:Human Resources Director | Professional in Human Resources (PHR) | Professional Certified Coach (PCC) | Strong international HR leadership | Experience with M&A, Spinoffs, Startups (180 characters) -If you are not actively job searching and want to leverage your LI profile for sales or other business, then start with your job title and company name | Your value proposition or keywords Example: Sales Leader, ABC Supply | Driving excellence in customer satisfaction with exceptional products, superior service after the sale, and generous referral incentives (163 characters) ORSales Director, ABC Supply | Value-Added Reseller (VAR) of commercial and residential kitchen and bath products from Kitchenaid, Whirlpool, Kenmore, Maytag, Bosch, Jacuzzi | Serving the greater Chicagoland area (210 characters) -If you are overtly job searching, then include your target job title as much as you legitimately can | Your value proposition or keywords (but never include Looking for Work or Seeking Opportunities) – divorce yourself from your current employer Example: Transformational Leader in Human Resources & Talent Acquisition | Delivering human capital and talent acquisition efforts that improve retention rates, reduce hiring costs, and increase profitability (199 characters) ORTransformational Human Resources & Talent Acquisition Leader | Workforce Planning | Pipeline Development | HRIS | Streamlining TA processes, improving retention rates, and reducing hiring costs (193 characters) -If you are unemployed, you can (and should) be overt. You don't have a current job title, so you want to make sure your target job title is included in your headline. Example:Mechanical Engineer | Extensive technical background, strong problem-solving skills, and the ability to see around corners | Streamlining processes | Educating and empowering team members (188 characters) OR: Mechanical Engineer | Advanced Thermodynamics | Advanced Fluid Mechanics | Human Robotic Systems | Optical Engineering | Metamaterials | Extreme Materials | Analytics & Statistical Learning | Engineering Finance (211 characters) -If you are looking to make a career pivot and are doing so covertly, massage your current job title towards what you are looking for | Include keywords for your new career as much as possible Example: (currently in marketing; wants to move into sales) Sales & Marketing Leader | Delivering exceptional sales support with marketing strategy and collateral | Experience with Salesforce | Strong business development skills | Competitive drive to succeed (199 characters) ORSales & Marketing Leader, B2B and B2C | Salesforce | Sales Support | Business Development | Social Media Marketing | Marketing Collateral | Lead-Generation | Account Management (176 characters) In summary, your LinkedIn headline should NOT be your current job title and employer. Think like a recruiter who would be searching on LI for someone like you – what would cause them to stop searching and spend time on your profile? If you are job searching, include your aspirational job title as closely as you can. Finally, don't try to cover too much real estate with your headline. Rather than appearing capable of a lot of things, it will likely make you look unfocused. Are you in the wrong job that chips away at you every day? The CareerSpring document and coaching program will help you find a job that uses your zone of genius, recognizes your value, and pays you what you're worth. If you're ready to take your job search to the next level by working with a highly experienced professional with a track record of client success, schedule a complimentary consult to learn more: https://calendly.com/lesaedwards/zoom-meetings2
238: Birmingham Diamond League | USATF Distance Classic This episode of the Inside Running Podcast is brought to you by PILLAR Performance – Australia's leading sports micronutrition brand – providing high-strength formulations to support recovery, elevate energy and relieve joint inflammation for endurance athletes. Available online now at pillarperformance.shop Brad accelerates his training volume ahead of Gold Coast in 6 weeks time. Julian keeps watch over Pia while floating the idea of softly getting back into cross country. Brady skims through the Moose Fartlek and welcomes some newcomers to the Barmah Park loop. Birmingham Diamond League featured more Australians, with Oliver Hoare scores bronze in the Men's 1500m in 3:35.76, with Matt Ramsden running 3:39 and Stewy McSweyn in 3:44.14. Peter Bol followed up his performance in Doha with a 1:47.59 in the 800m. Jessica Hull takes a narrow silver placing just behind Laura Muir, in 4:03.42 and ahead of Winnie Chebet of Kenya. In the Women's 5000m, Rose Davies ran 15:28.47 and Izzy Batt-Doyle closely behind in 15:29.05. Birmingham Diamond League Results Abby Caldwell took the win in the 1500m 4:04.18 at the USATF Distance Classic, Walnut California, securing her World Champs qualification. Jack Bruce came 3rd in 13:39.44 for the Men's 5000m, ahead of Sam McEntee in 7th and Kang Nyoak in 8th. Paige Campbell also featured in the women's 5000m. Matt Clarke ran 8:33 and Max Stevens posted 8:45 in the Men's Steeplechase while Amy Cashin won the Women's Steeplechase in 9:31.28, with Brielle Erbacher 5th in 9:46.29. USATF Distance Classic Results https://www.instagram.com/p/Cd4oSiwL9vF/ Jack Rayner came 2nd in the Great Manchester 10k in 28:16, 10 seconds behind winner Jake Robertson of New Zealand. Results via World-Track Shelby Houlihan loses her appeal on her doping ban, remains ineligible to compete until January 2025. NBC Sports Report Jessica Stenson took out the SA 10k Road Champs in 32:59 at West Beach ahead of Jess Pascoe and Brooke Hines. Adrian Potter takes the win in 29:07 ahead of brothers Jacob Cocks and Riley Cocks. SA Athletics Results St George Classic 10k XC held the Novice Champs won by Dylan Offord and Asha Martin while the open race was taken out by Ben St Lawrence and Naomi Tacred. Athletics NSW Results Listener Question asks how to balance running with being a new parent Moose gives this week's training talk presented by Lululemon: - 5x300m, 100m recovery w/400m jog recovery Moose explains how this workout designed reintroduction to faster workouts, with an emphasis on the recovery periods and the importance of group training. Moose spruiks the Nike Aeroswift Tights, then boys wrap up with a preview of the fields in a loaded Diamond League Pre Classic this Saturday 28th May. Tickets are now on sale for the IRP Gold Coast Marathon Live Show presented by Pillar Performance to be held at the Southport RSL on Sunday 3rd July after the event. Patreon Link: https://www.patreon.com/insiderunningpodcast Opening and Closing Music is Undercover of my Skin by Benny Walker. www.bennywalkermusic.com Join the conversation at: https://www.facebook.com/insiderunningpodcast/ To donate and show your support for the show: https://www.paypal.com/cgi-bin/webscr?cmd=_s-xclick&hosted_button_id=9K9WQCZNA2KAN
The San Francisco Giants' starting rotation has been the unluckiest unit in baseball. They've allowed the highest BABIP, and as a team they have the biggest gap between their ERA and their FIP. Results are all that matters in the end, but it's hard to explain these numbers with anything other than luck. Maybe a bit of bad defense, too. It happened to Alex Cobb again last night. He was cruising along before five runs came across after two were out. Three bloop hits with two outs ended up scoring two runs, then Pete Alonso really made the SF Giants pay with a back-breaking three-run homer. It was too much to overcome, and Cobb (6.25 ERA, 2.73 FIP) has by far the biggest gap between his ERA and his FIP among pitchers with at least 30 innings pitcher. Carlos Rodón and Alex Wood are also in the top 13 in that category among 127 pitchers with at least 30 IP. The team is on its second five-game losing streak in the month of May. It's been an ugly stretch of baseball, bad fortune being just a part of it. Looking down to the minors for some potential help and/or bright spots, David Villar remains a call-up candidate as he continues to dominate in Triple-A. He would need to be added to the 40-man roster. Kyle Harrison, meanwhile, earned a promotion to Double-A after he struck out exactly half of the 118 batters he faced this season. He was great in San Jose last year, and somehow managed to get significantly better in Eugene this year. Harrison is just 20 years old, and he's getting closer to the major leagues. His rise is something for Giants fans to watch very closely. Find and follow Locked On Giants on your favorite podcast platforms:
Each month, presidential pollster, Harris Poll Chairman and Stagwell Global Chairman & CEO MARK PENN and BOB CUSACK, Editor in Chief of The Hill discuss the findings of the latest Harvard CAPS / Harris Poll. This month's survey of 2,000 registered voters was conducted May 18-19, 2022. When asked how he'd sum up the mood of the country in just one word, Penn offered "INFLATION". The Harvard CAPS / Harris Poll is a monthly poll released by Harvard's Center for American Political Studies and Harris Insights and Analytics. Conducted online within the United States, every monthly survey captures the responses of over 2,000 registered voters. The results reflect a nationally representative sample. Results were weighted for age within gender, region, race/ethnicity, marital status, household size, income, employment, and education where necessary to align them with their actual proportions in the population. Propensity score weighting was also used to adjust for respondents' propensity to be online.
Interested in how to ethically use scarcity marketing in your business? Using scarcity is definitely effective, but how do you implement scarcity marketing and stay ethical? Jacques Hopkins joins me in this episode to talk about a recent experiment he ran in his business that totally changes the way I think about scarcity marketing.In this episode, We'll dive into:-What kept Jacques going through 7 failed business attempts-3 different ways to implement scarcity to your marketing funnels-Results from the experiment Jacques performed on his funnel that 10xed his online course sales.Resources:For show notes and free resources: www.businesssavvyshow.comFollow:www.instagram.com/hellosavvycowww.facebook.com/hellosavvycoConnect With Jacques:Instagram: https://instagram.com/pianoin21days Podcast: The Online Course Showhttps://pianoin21days.com/Sponsored by:HelloSavvy HelloSavvy is a new freelancer marketplace that is changing the way hiring happens online. HelloSavvy helps you find freelancers that will align with your company's mission and vision. You can even filter freelancers by personality type and the specific tools you use in your business! Ready to scale your business by hiring the right people? Head over to Hellosavvy.com to learn more.
A lot of content writers struggle when it comes to pricing. They are great at what they do but they have the employee mindset. The problem is they don't go out there and get help in improving their sales and marketing skills because these are different skills that they need to acquire. They have the skill to do the job but they don't have the skill to sell the service. So, we got Francielle joining us today to give her expert pricing strategies and selling your service.About FrancielleToday's guest is Francielle Silva. She was born and raised in Brazil but moved to Canada 8 years ago and worked as a caregiver. She has a lot of experience and built a community on Facebook called the Newbies Copywriters & Content Writers.She started out as a copywriter last year and she is transitioning into a business coach because she loves helping people and she got some who are requesting her service. She used some strategies that work. Now, she is leveling up by focusing as a business and visibility coach to help her clients stay visible on social media.Key points we've discussed:Pricing strategies without sounding salesyFrancielle provides a downloadable pricing guide for our Savvy Nurse Writer membersGet the pricing you deserve without chasing away clientsTips for getting testimonials from your clientsTo charge per hour or notTips for Pricing your ServicesWhen you charge very low, you are also attracting low-paying clients that will not trust you. High-paying clients pay for their time and they want RESULTS.It's important to ask your clients before you charge: what do they want to get from your service?Don't charge per hour.Don't try to persuade your clients to start off with a service that they don't have. Just start off with what they want and deliver value.Don't just work with start-up companies because they might not sustain the budget to keep working with you all the time. So, it is important to expand your service to established businesses as you grow.If you keep getting money objections, it's a red flag for you.You don't have to have 10 years of experience to charge a higher rate.If you want to have consistent clients, you need to be consistent with your business and you need to provide consistent value.Keep listening to this episode for more tips!Tips for Getting Testimonials From Your ClientsSend your client a request for a testimonial by answering these 3 essential questions:How are you feeling, what are you struggling with before we start working together?How was working with me?What did you get after working with me? Or what problem did I help you to solve?Support the show
Lots of people have asked us questions about building their personal brand. The two questions we most often get are: “How long DOES it take to build your brand? and “When should I start seeing RESULTS?” In this episode, Tonya and Michael share the answers to those questions with great transparency and detail. If you have more questions about building your personal brand, leave them in the comments and we'll make sure to get each of them answered!
Nutrition for fat loss and muscle growth is simple, there's just a lot of confusion and conflicting information. In this episode I share the secret to long term, easy and sustainable fat loss.The Ultimate Flexible Dieting GuideClick Here To Become a VIP member (Join DK's coaching app here)SHOP DKFITNESS MERCH HEREwww.younifyactive.com DKFITNESS at checkout for 15% offUse code DJK10 on all EHPlabs supplements for 10% offUse code DK15 on all Athletikan Sneakers for 15% offIntro by Will Sparks.Find this episode helpful? Share it with a friend or post a screenshot to your social media.
RotoViz Analyst Michael Dubner joins the show to discuss his Best Ball Tool for tracking Player Exposures, Stack Tracker, Roster Constructions, Results, and more. Subscribe and listen along as the guys look at the keys of the format, the best roster strategies, and tools to use to win your league, Zero RB, and much more! Click here for Michael's FREE Best Ball Tool Subscribe to the RotoViz YouTube Channel here! HOST Colm Kelly (@OvertimeIreland) – Executive Producer of RotoViz Radio GUEST Michael Dubner (@Dubner_Michael) – Analyst/Writer at RotoViz.com The Best Ball Show is powered by RotoViz Radio. SPONSORS RotoViz - RotoViz Radio listeners can save 10% off of a 1-year RotoViz subscription at RotoViz.com/podcast or by applying the discount code 'rvradio2022' at checkout. SHOW NOTES Email: RotoVizRadio@gmail.com Twitter: @RotoVizRadio Learn more about your ad choices. Visit podcastchoices.com/adchoices
Could probiotics restore microbiome imbalance linked to autoimmune disorder? UCLA and Oslo University Probiotics might help restore gut bacterial imbalance in patients with systemic sclerosis, says a new study looking at gastrointestinal bacterial compositions in two geographically-distinct populations suffering from the autoimmune disorder. Systemic sclerosis is an autoimmune disease which impacts the body's connective tissue. It is an uncommon condition that results in hard, thickened areas of skin and sometimes problems with internal organs and blood vessels.The study ran across the US and Norway and found that Norwegians and Americans with systemic sclerosis had higher levels of bacteria which can cause inflammation and lower levels of bacteria which are said to protect against inflammation compared to those not suffering from systemic sclerosis.The study found that those with systemic sclerosis had significantly lower levels of gut bacteria which is thought to protect against inflammation, such as Bacteroides.They were also found to have higher amounts of bacteria which promote inflammation, such as Fusobacterium, in comparison to those without systemic sclerosis.The study suggests that probiotics may aid restoring gut bacterial balance in those suffering from systemic sclerosis. Caraway extract shows slimming potential for women University of Malaya (Malaysia), An aqueous extract of caraway seeds may suppress appetite and help slim waistlines and thighs in physically active women, says a new study. Data published in Phytotherapy Research indicated that 90 days of supplementation with the caraway (Carum carvi L.) extract led to significant reductions in waist circumference of 6.2 cm and thigh circumference of 5.4 cm, compared to baseline levels. No significant waist reductions were recorded in the placebo group. “This study showed that the consumption of 30 mL/day CAE [caraway aqueous extract] may result in reasonable anti-obesity effects,” wrote the researchers. “Most likely, this occurs through a combination of four major bioactivities, including anti-microbial, anti-oxidant, and anti-inflammatory properties, together with the appetite-suppressing activity. Scientists from the University of Malaya (Malaysia), Shahid Beheshti University of Medical Sciences (Iran), and Natural Products Inc (USA) recruited 70 aerobically trained, overweight, and obese women to participate in their triple-blind, placebo-controlled, clinical study. The women – who were instructed to not change their diet or physical activity – were randomly assigned to receive either the caraway extract or placebo for 90 days. Results showed that women in the caraway group had significant reductions in both appetite levels and carbohydrate intake compared with the placebo group. Commenting on the potential bioactives compounds responsible for the effects, the researchers note that caraway seed extracts contain volatile compounds such as limonene, gamma-terpinene, trans-carveol, carvone, thymol, and carvacrol. Friends Provide Better Pain Relief Than Morphine, Oxford University Study Reveals Oxford University Recent studies have explored the science behind friendships and discovered that there are actually measurable differences between people who have strong, healthy social networks and those who don't. In particular, people with strong friend connections were found to experience significantly better states of physical and mental health. “People with social support have fewer cardiovascular problems and immune problems, and lower levels of cortisol — a stress hormone,” says Tasha R. Howe, PhD, associate professor of psychology at Humboldt State University. Adding to the growing research on the benefits of friendship, a recent study conducted by researchers at Oxford University established that people with more friends have higher pain tolerance. The study was designed to use pain tolerance to test the brain's endorphin activity. The researchers theorised that people with larger social networks would, as a result, have higher pain tolerance. The findings of the study supported their theory in that it showed that indeed, strong social connections were correlated with higher pain tolerance. As mentioned in the final statement it is not just the size of our social network that is important to our wellbeing, but the quality of the friendships that matters as well. With the advent of the internet modern society is changing quickly, and our interactions are increasingly occurring online. Even though the internet can be a great way to connect with likeminded people, online friends just aren't the same as those we can actually sit with and look directly in the eye when we communicate–and a digital hug is just nowhere near as good as a real one! Videos: 1. Pfizer CEO Albert Bourla explains Pfizer's new tech to Davos crowd (0:25) 2. You'll Never See This on Tell Lie Vision (2:19) 3. Jimmy Dore- TV War “Experts” Revealed As Paid Shills For Weapons Manufacturers (only first 6:00) 5. SHOCKING! Assad Spills Truth About Ukraine Conflict and NATO by Richard Medhurst (11:50)
The world is changing every single day. If you remember AOL, you might be what's considered “Old,” and if you don't, now you have the ability to Google it. We live in a day and age where technology has made life much easier and the obstacles of insufficient budgets, low-tech, costly manpower, and expensive retail space are truly a thing of the past. We're moving at lightening speed and our ability to learn, process, and implement immediately in today's society is compressing time and creating space for you to live your life as intended. Marco Torres is Co-Founder of Marketing Boost, which helps entrepreneurs engage with their clientele, get more opportunities at a “Yes” and close more sales. His vast background in marketing began in the foundations of what has led to modern-day marketing. Marco shares a few of his hidden gems most marketers won't share with you. Today, Jason, Steve, and Marco have a killer discussion as they dive into a flashback of the early days of the internet, discussing AOL, and tedious coding processes that are no longer used. Marco shares some of the challenges he had in the early days and share some proven psychological research to help you engage and close your prospects converting them into clients for life. He shares how they took a simple marketing campaign and rocket-launched a successful travel company back in 2010. That same company is now used to offer complimentary hotel stays in locations around the world, hotel savings cards that allow you to “buy down” your rate during your stay, and restaurant savings vouchers. If you've been looking for a way to make an impact by leading with value, you've tuned in to the right episode today. Listen closely for a special offer Marco makes to all listeners of today's episode. What You'll Learn: Why it's a great time more than ever to be an entrepreneur What AOL was back in the 1990s The difference between technology today and 25 years ago Apps, automations, and other tech stacks that will make your life and business easy The power of the “value add,” what it is, and what it means to Marco What Marketing Boost does and how it can help incentivize your clients Psychological studies taht prove adding items as opposed to discounts closes more sales Why selling on price is commoditizing your business and training your clients to be the worst on the planet How using video reviews and testimonials helped launch a successful travel company in 2010 Results of a survey you can implement in your business starting today using text and email How you can save tons of cash on hotel stays, obtain complimentary hotel stays for your clients, and get restaurant savings vouchers The difference between a “sales funnel” and “website” Where you should drive traffic A special offer for anyone who listens to this episode Favorite Quote: “The bottom line is anything you do over and over everyday, you need to build a process for it and outsource it and hire somebody in the world to do it. Each time you do that, you can start looking at your business from 30,000 miles above and start having the business working for you instead of you working in the business every day. It sounds intimidating at the start when you have a small budget, and you're just starting, but if you think small, you'll be small.” Marco Torres Connect With Marco: Facebook Marketing Boost Special Offer For Listeners of This Podcast How To Get Involved: Find Jason on Instagram & Facebook. Find Steve on Instagram & Facebook. No Bull Business & Brews on Facebook Get Jason's #Best Selling Book: See and Seize: Lessons From Merging and Acquiring Agencies and Assets Enjoyed the episode? Hop over to Apple Podcasts for more! Like and share to help spread the word. We appreciate your support—and we hope to return the favor: Leave a review to let us know what you want to hear from Jason and Steve next.
While those with "equipping gifts" prepare others' heads and hearts for the work of ministry through discipleship, those with "service gifts" do the hands-and-feet work of ministry. Most of us have several spiritual gifts that the Holy Spirit arranges in "clusters" that help us minister effectively to others in the Church. In this episode, we explore types of service clusters and begin unpacking the nuances of individual service gifts. Thank you to my newest Friends of the Show Julie S; Bonnie C; Elizabeth Mc; Margie Y; Laura B; and Katherine A, for loving and lifting me! Friends of the Show get all Premium Content and monthly meet-ups with Sonja! LOVE the Word® is a Bible study method based on Mary's own practice: lectio without the Latin. Get the book based on Sonja's method in the right margin, How to Pray Like Mary. L | Listen (Receive the Word via audio or video.) O | Observe (Connect the passage to your life and recent events.) In evaluating your gifts, can you discern a particular arrangement that could make you effective in a specific ministry endeavor? Have you identified an underserved "gap" in your parish? Could that be the Holy Spirit inviting you to offer or begin something new? V | Verbalize (Pray about your thoughts and emotions.) Remembering that He loves you and that you are in His presence, talk to God about the particulars of your O – Observe step. You may want to write your reflections in your LOVE the Word® journal. Or, get a free journal page and guide in the right-hand margin. E | Entrust (May it be done to me according to your word!) Come Holy Spirit, fill the hearts of Your faithful. Enkindle in them the fire of Your love, and there shall be a new creation, and You shall renew the face of the earth. Amen. + Bible Study Evangelista is on the Laudate app! Connect I am no longer on Facebook. Join us in the new community forum, where we're talking about spiritual gifts, daily LOVE the Word takeaways, healing, caregiver support, and lots more. What We Discussed | Show Notes Overview: Minutes 00:12:00 – Results of the spiritual gifts quizzes; gift clusters: Service gifts: administration Minutes 12:01-24:00 – caregiving, craftsmanship Minutes 24:01-36:00 – discernment, encouragement, faith, generosity Minutes 36:01-48:00 – hospitality, intercession, mercy, mission, musicianship, trust Resources Decree on the Apostolate of the Laity, Pope Paul VI On the Vocation and Mission of the Lay Faithful in the Church and in the World, Christefideles Laici, Pope John Paul II Fruitful Discipleship, Sherry Weddell Iuvenescit Ecclesia, The Relationship Between Hierarchical and Charismatic Gifts in the Life and the Mission of the Church, Congregation for the Doctrine of the Faith Transcript Click here for a transcript of the show.
Results, results, results. This is what the junior golfer wants, and arguably what us adults want as well. But is it the most important thing? At the time, it may seem that way, but lets remember, we want to be raising good people. In this episode I will discuss what I feel are some important areas we would be preaching to junior golfers.
Many have asked so today is the day! Join me as we talk about the LIFT(her) program and the upcoming Inspire(her) 3 Day Results Challenge. We take a deeper dive into the value of both and answer some questions that have been asked about LIFT(her) results. I am very proud of both and the incredible women who are taking the lead in their lives and creating their abundant life both professionally and personally. It is my mission to help women who are ready to create the change and growth they want in their lives, businesses, careers, and relationships. These women may not yet understand that they are leaders (and some do) in their lives and are ready to be bold and act by creating new habits, beliefs and behaviors leading them to their biggest and most meaningful outcomes. I want women to seize every single moment and know they deserve the abundant life they desire. Highlights from this episode: (02:07) The method behind the motivation (05:23) There's no stopping us (09:11) LIFT(her) gets mind-blowing results! (14:08) What is your genius? (18:02) Get clear on your intentions As mentioned in this episode: Share your Curiosity Challenges, learnings, and any questions here! Around the Corner: Join Coach Kelly on June 1st at 12:00 p.m. PST for an exciting Inspire(her) Results 3 Day Challenge designed to help you make decisions using tips/tools/strategies from The LIFT Method that will have you acting instead of waiting. Click here to read more about it and join! The LIFT(her) 12 month Group Coaching for Women has launched and the next group starts on 6/15/22. CLICK HERE and join us for the NEW Group Coaching Program for Women using the four pillars of The LIFT Method to create an EPIC year of impact, growth, and success. The next group starts 6/15/22. Got questions? Email us here If you enjoyed this episode please share it with a friend, and it would mean so much if you could take a quick moment to write a REVIEW on Apple Podcasts. Connect with Coach Kelly and for more resources please visit: www.kellyjmobeck.com Let's Get Social, follow Coach Kelly: @KellyMobeck on LinkedIn @KellyMobeck on Instagram Let us know any questions in life you have, and what you would love to hear more about, we are happy to help and will take these on in future episodes.
A "Zip Bomb" to Bypass Security Controls & Sandboxes https://isc.sans.edu/forums/diary/A+Zip+Bomb+to+Bypass+Security+Controls+Sandboxes/28670/ Cisco IOS XR Software Health Check Open Port Vulnerability https://tools.cisco.com/security/center/content/CiscoSecurityAdvisory/cisco-sa-iosxr-redis-ABJyE5xK pwn2own Vancouver 2022 Results https://www.zerodayinitiative.com/blog/2022/5/18/pwn2own-vancouver-2022-the-results#three Malicious PyPi Packages Drop Cobalt Strike https://blog.sonatype.com/new-pymafka-malicious-package-drops-cobalt-strike-on-macos-windows-linux Security Advisory for BR200, BR500 and PSV-2021-0286 https://kb.netgear.com/000064712/Security-Advisory-for-Multiple-Security-Vulnerabilities-on-BR200-and-BR500-PSV-2021-0286
Hosts Mat Bradley-Tschirgi, Thrasher, BJ, and special guest Rudie Obias (freelancer writer for Mental Floss) discuss Star Wars Episode II Attack of the Clones. A whiny teenager massacres a village while professing his love to an older woman. The lowest grossing of the Star Wars Prequel Trilogy, Star Wars Episode II Attack of the Clones takes place a handful of years after Star Wars Episode I The Phantom Menace. Anakin is now a petulant teenager fawning over Queen Amidala. Obi-Wan Kenobi has a beard and more sass than before. Part murder mystery, part love story, and part political quagmire, Attack of the Clones has too much story going on and kind of drags for much of its running time. However, not all is lost. Writer and director George Lucas seems giddy here exploring a cacophony of settings and ideas; if nothing else, the whole enterprise feels less leaden than The Phantom Menace. Christopher Lee as Count Dooku makes a nice pairing with senior baddie Ian McDiarmid as Senator Palpatine. Both actors can bluster their way through even the most banal dialogue. Sequelcast 2 and Friends is part of the HyperX Podcast Network. Follow the show on Twitter @Sequelcast2 Buy Marc with a C's music at Bandcamp Buy Mat's books (How to Buy a PlayStation 5 [Results not Guaranteed], Podcast You Nerd!) Buy Thrasher's tabletop RPG supplements from DriveThruRPG Watch Alex Miller's YouTube series The Trailer Project Groundwork by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3832-groundwork License: https://filmmusic.io/standard-license
Watch the video on our YouTube channel "SKULLBELLZTV!" Brandon Bebo, “your favorite pothead bodybuilder,” is a highly competitive middle weight NPC athlete and coach. The passion this young man has for the sport is clearly evident in his: 1. Consistently Outstanding body composition and presentation 2. Results of his clients which from I've seen are always in top shape 3. No bullshit, relentless, all-or-nothing attitude he brings to what seems to be all areas of life, whether it's his own workouts, bringing the best out of his competitors, even training his 2-year old WOLF/DOBERMAN/BLUE-NOSE-PIT named Primo! Every conversation with Brandon has left me with valuable takeaways. He an I are actually competing AGAINST each other this fall, September 10, 2022. MEDICAL DISCLAIMER: Please check with your doctor before implementing any of the topics we discuss on this show. We are not medical professionals. We are athletes and coaches. Email Brandon for competition coaching: email@example.com @bigyoungbebo / Brandon Bebo Noe
Blueberries can lower the risk of cardiovascular disease in postmenopausal women with high blood pressure Colorado State University, May 19 2022 Consuming blueberries can lower the risk of cardiovascular disease in postmenopausal women with high blood pressure, according to new research by Colorado State University faculty member Sarah Ardanuy Johnson. Consumption of 22 grams of freeze dried blueberry powder (equivalent to about 1 cup of fresh blueberries) mixed with water taken daily for 12 weeks improved the function of the inner lining of blood vessels (called the endothelium), according to preliminary findings of a study. They performed a randomized, double-blind, placebo-controlled, parallel-arm clinical trial in 43 estrogen-deficient postmenopausal women aged 45-65 years with elevated blood pressure or stage 1-hypertension. Johnson's research team used freeze-dried blueberries to retain the polyphenols as much as possible, and to allow for the study to be double-blind, meaning that neither the investigators nor the study participants knew whether they were getting the treatment (blueberry) or placebo. Johnson said the team observed increases in blood metabolites that are products of metabolism of anthocyanins (polyphenols found in blueberries that give them their blue color) and metabolism of polyphenols by the gut microbiome. Diet plays key role in ADHD symptoms in children Ohio State University, May 20, 2022 Here's a good reason for children with attention deficit hyperactivity disorder (ADHD) to eat their fruits and vegetables: It may help reduce inattention issues, a new study suggests. Results showed that kids who consumed more fruits and vegetables showed less severe symptoms of inattention, said Irene Hatsu, associate professor of human nutrition at The Ohio State University. The study that evaluated the effectiveness of the supplement showed that children who took the micronutrients were three times as likely to show significant improvement in their ADHD and emotional dysregulation symptoms than those who took a placebo. Higher dose of melatonin improved sleep in older adults Harvard University, May 19, 2022 In a small study of healthy adults aged 55 and older, 5 mg of melatonin increased total sleep time compared to a placebo. Researchers conducted the study in 24 healthy, older adults to evaluate whether a high-doseor a low-dose melatonin supplement could improve sleep. The team found that the higher dose had a significant impact, increasing total sleep time compared to placebo by more than 15 minutes for nighttime sleep and by half an hour for daytime sleep. Results are published in the Journal of Pineal Research. The body naturally produces the hormone melatonin, which helps regulate a person's sleep-wake cycle with night and day. Melatonin levels peak at night. But among older people, levels of the hormone are often lower. The team found that the low dose of melatonin did not lead to a statistically significant change in overall sleep time and that the changes that were seen were when sleep was scheduled during the biological day. Participants taking the 5 mg dose had a significant increase in total sleep time and sleep efficiency regardless of whether sleep was scheduled during the day or night. Sound Waves Boost Older Adult's Memory, Deep Sleep Northwestern University, May 14, 2022 Gentle sound stimulation—such as the rush of a waterfall—synchronized to the rhythm of brain waves significantly enhanced deep sleep in older adults and improved their ability to recall words. This is according to a Northwestern Medicine study. Deep sleep is critical for memory consolidation. But beginning in middle age, deep sleep decreases substantially, which scientists believe contributes to memory loss in aging. The sound stimulation significantly enhanced deep sleep in participants and their scores on a memory test. The degree of slow wave sleep enhancement was related to the degree of memory improvement, suggesting slow wave sleep remains important for memory, even in old age. Mulberry extract may ‘activate' brown fat, help treat obesity Chinese Academy of Sciences, May 9, 2022 Researchers from the Chinese Academy of Sciences say obesity can be treated by using a natural compound in mulberries that “activates” brown fat.The compound, known as rutin, was found to have weight loss properties in a study published in The FASEB Journal. Researchers say this may not only be able to help treat obesity, but related diseases associated with excessive weight gain.”The beneficial effects of rutin on BAT-mediated metabolic improvement have evoked a substantial interest in the potential treatment for obesity and its related diseases, such as diabetes,” researcher Wan-Zhu Jin said in a press release. During the experiment, supplemental rutin was added to the drinking water of both groups. Researchers observed improved glucose homeostasis in both cohorts. The investigators concluded the rutin improved metabolic functions in the mice. Scientists are confident similar remedies can be used to treat obesity in humans. Psychedelic drugs promote neural plasticity in rats and flies University of California Davis, May 12, 2022 Psychedelic drugs may have mind-altering powers in the physical sense, too. A new study, published in the journal Cell Reports, found psychedelics, specifically DOI, DMT, and LSD, can change brain cells in rats and flies, making neurons more likely to branch out and connect with one another. The work supports the theory that psychedelics could help to fight depression, anxiety, addiction, and post-traumatic stress disorder. “These are some of the most powerful compounds known to affect brain function, it's very obvious to me that we should understand how they work,” says senior author David E. Olson, assistant professor at the University of California, Davis. The idea that depression stems from imbalanced brain chemistry remains popular, but recent studies have revealed evidence that depression manifests as structural changes in brain circuits or atrophy in parts of the brain. This doesn't mean neurons die off during depression, but that neurites retract. Neurites are the sections—either axons or dendrites—of a neuron that project out to bridge the gap between two neurons at the synapse to facilitate communication. “One of the hallmarks of depression is that the neurites in the prefrontal cortex—a key brain region that regulates emotion, mood, and anxiety—those neurites tend to shrivel up,” says Olson. These brain changes also appear in cases of anxiety, addiction, and post-traumatic stress disorder. In their paper, Olson and colleagues tested psychedelics and showed some psychedelics tested, including LSD, proved to be more potent and efficacious in promoting neurite growth. Videos : 1. Whoa! Rand Paul spitting truth bombs like a rocket launcher 2. Preparing for
Respect The Voodoo™ The "NEW" Revolutionary Hoodoo New Orleans Voodoo Secrets and Recipes Respect The Voodoo™ Psychics can predict But Hoodoo New Orleans Voodoo Secrets and Recipes get Results! www.HouseoftheDivinePrince.com DivinePrince@HouseoftheDivinePrince.com NOON US CST on Blog Talk Radio! Host | Member since Dec 23, 2008 Pan African Spiritualist Practitioner Author and Advisor I will be FORWARD (NOON US CST) with more Revolutionary Hoodoo New Orleans Voodoo Secrets and Recipes! ATR Spirituality and Religion from a Pan African Hoodoo World Spiritualist perspective. Listen in and Call in (And ALWAYS In-Archive at Your Leisure and Convenience) GUEST CALL-IN (515) 605-9718 https://www.BlogTalkRadio.com/The-Divine-Prince All is a Blessing! #RespectTheVoodoo
This week Deborah reveals the key questions leaders should be asking about how team engage and when to focus on independent work vs. collaboration. Listen in as she explores indicators that silos are working in your business as well as red flags when it's time to bring the team together. Create a personal career strategy that develops the leadership and communication skills you need to assess challenges, showcase your skills, and demonstrate your ability to be a C-Suite Leader. Learn more about the C-Suite Academy here: https://bit.ly/csawaitlist22 See omnystudio.com/listener for privacy information.
This week we discuss the "sum of the parts" of Rackspace, Rocky Linux recreates CentOS and thoughts on the economy. Plus, a debate: rental car vs. Uber. Rundown Rackspace Technology Reports First Quarter 2022 Results; Company Evaluating Strategic Alternatives (https://ir.rackspace.com/news-releases/news-release-details/rackspace-technology-reports-first-quarter-2022-results-company) Cloudflare gets serious about infrastructure services (https://techcrunch.com/2022/05/11/with-new-serverless-database-cloudflare-gets-serious-about-infrastructure-services/) Rocky Linux developer CIQ raises $26M to recreate CentOS for enterprises (https://venturebeat.com/2022/05/11/rocky-linux-developer-ciq-raises-26m-to-recreate-centos-for-enterprises/) Snowflake Stock: Finally, This Software Titan Is Worth A Nibble (NYSE:SNOW) (https://seekingalpha.com/article/4511737-snowflake-worth-nibble) Job vacancies outpace unemployment for first time (https://www.bbc.co.uk/news/uk-61475720) Relevant to your Interests Observability Engineering - O'Reilly Book 2022 Download (https://info.honeycomb.io/observability-engineering-oreilly-book-2022) Observe raises $70M to grow its data-fueled observability platform (https://siliconangle.com/2022/05/11/observe-raises-70m-grow-data-fueled-observability-platform/) Apple discontinues its last iPod (https://www.engadget.com/apple-discontinues-ipod-touch-161433001.html) Ploopy. Open-source hardware. (https://ploopy.co/) DigitalBridge to Buy Switch for $11 Billion as Data Center M&A Binge Continues (http://) Aiven Raises $210M to Invest in Sustainable Open Source Cloud (https://www.businesswire.com/news/home/20220511005232/en/Aiven-Raises-210M-to-Invest-in-Sustainable-Open-Source-Cloud) Workforce management startup Rippling raises $250M at $11.25B valuation (https://siliconangle.com/2022/05/11/workforce-management-startup-rippling-raises-250m-11-25b-valuation/) Google finally announces the Pixel Watch (https://www.theverge.com/2022/5/11/23064072/google-pixel-watch-fitbit-io-2022) IBM's massive 'Kookaburra' quantum processor might land in 2025 (https://www.popsci.com/technology/ibm-quantum-computing-roadmap/) Google Cloud launches AlloyDB, a new fully managed PostgreSQL database service (https://techcrunch.com/2022/05/11/google-cloud-launches-alloydb-a-new-fully-managed-postgresql-database-service/) Komodor provides a Kubernetes troubleshooting platform (https://techcrunch.com/2022/05/12/komodor-is-building-kubernetes-troubleshooting-platform-for-the-masses/) Nvidia Does the Unexpected: Open Sources GPU Drivers for Linux (https://thenewstack.io/nvidia-does-the-unexpected-open-sources-gpu-drivers-for-linux/) Hands-Free Voice Control | Sonos (https://www.sonos.com/en-us/sonos-voice-control) Appeals court unleashes Texas's anti-content-moderation law (https://www.theregister.com/2022/05/12/appeals_court_lets_texas_law/) Chicken Soup for the Soul Entertainment acquires Redbox (https://techcrunch.com/2022/05/11/chicken-soup-for-the-soul-entertainment-acquires-redbox-for-375m-to-accelerate-its-streaming-business/?tpcc=tcpluslinkedin) Hasura raises $100M to create GraphQL APIs for databases (https://twitter.com/mamund/status/1525142084138713092) Jeffrey Snover claims Microsoft demoted him for PowerShell (https://www.theregister.com/2022/05/10/jeffrey_snover_said_microsoft_demoted/) Amazon CEO Andy Jassy's $214 million pay package is 'excessive' and should be vetoed by shareholders, say advisory firms (https://www.businessinsider.com/amazon-ceo-andy-jassy-salary-excessive-report-vote-down-2022-5) Netflix tells employees they can quit if they don't want to work on content they disagree with, according to new company culture guidelines (https://www.businessinsider.com/netflix-company-culture-guidelines-employees-can-quit-if-they-disagree-2022-5) Not all open-source leaders are jerks (https://www.theregister.com/2022/05/12/not_all_opensource_leaders_are/) Intel Poaches Open Source Execs from Netflix, Apple to Boost Linux Efforts (https://thenewstack.io/intel-poaches-open-source-execs-from-netflix-apple-to-boost-linux-efforts/) Jeff Bezos turns up heat on Joe Biden over US inflation (https://www.ft.com/content/8ef4934e-2072-4534-bce6-824fb0da8628) Satya Nadella details Microsoft plan for ‘significant additional investment' in employee compensation (https://www.geekwire.com/2022/satya-nadella-details-microsoft-plan-for-significant-additional-investment-in-employee-compensation/) Musk: Twitter deal at lower price "not out of the question" (https://www.axios.com/2022/05/16/elon-musk-twitter-deal-lower-price?utm_source=newsletter&utm_medium=email&utm_campaign=newsletter_axioslogin&stream=top) Google Lets Personal Users Stay On 'No-Cost Legacy G Suite' With Custom Gmail Domain (https://tech.slashdot.org/story/22/05/16/2121201/google-lets-personal-users-stay-on-no-cost-legacy-g-suite-with-custom-gmail-domain) Apple slows return to office, will let employees stay remote and require masks in common spaces (https://www.theverge.com/2022/5/17/23100696/apple-delay-hybrid-office-return-work-from-home-covid-19-masks?utm_campaign=theverge&utm_content=chorus&utm_medium=social&utm_source=twitter) For Tech Startups, the Party Is Over (https://www.wsj.com/articles/for-tech-startups-the-party-is-over-11652710330?mod=djemalertNEWS) The State of Kubernetes Security in 2022 (https://www.redhat.com/en/blog/state-kubernetes-security-2022-1) Facebook's hiring crisis: Engineers are turning down offers (https://www.protocol.com/workplace/facebook-docs-hiring-recruiting-crisis) Twitter bleeds more top talent in the midst of Musk acquisition (https://www.protocol.com/bulletins/twitter-executives-departure-musk) Sisters doing it for themselves: this nun built her own power plant (https://www.euronews.com/next/2022/05/16/sisters-doing-it-for-themselves-drc-nun-fed-up-with-power-outages-builds-own-hydroelectric) Google Cloud launches new software supply chain and zero trust security services (https://techcrunch.com/2022/05/17/google-cloud-launches-new-software-supply-chain-and-zero-trust-security-services/) Orbit + Hoopy: Writing the Future of DevRel - Orbit (https://orbit.love/blog/orbit-hoopy-writing-the-future-of-devrel) A beef over NFTs is shaking the sneaker industry - The Hustle (https://thehustle.co/05172022-Nike-StockX) Introducing the 2022 State of Crypto Report (https://a16zcrypto.com/state-of-crypto-report-a16z-2022/) Apple has shown its mixed reality headset to its board of directors: report (NASDAQ:AAPL) (https://seekingalpha.com/news/3841044-apple-has-shown-its-mixed-reality-headset-to-its-board-of-directors-report?utm_campaign=twitter_automated&utm_content=news&utm_medium=social&utm_source=twitter_automated) Why Did Heroku Fail? (https://matt-rickard.com/why-did-heroku-fail/) Docker Launches Docker Extensions and Docker Desktop for Linux (https://www.infoq.com/news/2022/05/docker-desktop-extensions-linux/?utm_campaign=infoq_content&utm_source=infoq&utm_medium=feed&utm_term=global) Nonsense Mailin' It! - The Official USPS Podcast (https://usps-mailin-it.simplecast.com/) Dad's take on Peloton from 2019 (https://twitter.com/peter/status/1524265098465792000?s=21&t=5jYSjrdL3mIVGMb-31qQtg) A solar power plant in space? The UK wants to build one by 2035. (https://www.space.com/space-based-solar-power-plant-2035) Elon discovers Lawyers (https://twitter.com/elonmusk/status/1525615849167589380?s=21&t=VVDN3Oxzsmu57Srayk2X1w) More Cables (https://twitter.com/rayredacted/status/1490088765112700928?s=21&t=TNzXDAprfUDBcUIehlJ5yw) Computer powered by colony of blue-green algae has run for six months (https://www.newscientist.com/article/2319584-computer-powered-by-colony-of-blue-green-algae-has-run-for-six-months/) Southwest introduces transferable credits (https://twitter.com/southwestair/status/1527001072132399104?s=21&t=jrhjV0241gVclZpxEP0vnQ) Listener Feedback Relyance AI is looking for a VP of Product (https://boards.greenhouse.io/relyance/jobs/4148931004) Conferences THAT Conference comes to Texas (https://that.us/events/tx/2022/), May 23-26, 2022 Discount Codes: Everything Ticket ($75 off): SDTFriends75 3 Day Camper Ticket ($50 off): SDTFriends50 Virtual Ticket ($75 off): SDTFriendsON75 cdCon, June 7 – 8, 2022 Austin, Texas + Virtual (https://events.linuxfoundation.org/cdcon/) Get a 40% disocunt with this code: CdCon22SDPod MongoDB World 2022 (https://www.mongodb.com/world-2022), June 7-9th, 2022 Splunk's ,conf (http://Splunk's> ,conf June 13-16, 2022), June 13-16, 2022 FinOps X (https://events.linuxfoundation.org/finops-x/), June 20-21, 2022, Matt's there! DevOps Loop (https://devopsloop.io), June 22nd. Free! Coté helps put the agenda together. Open Source Summit North America (https://events.linuxfoundation.org/open-source-summit-north-america/), June 21-24, 2022, Matt's there! THAT Conference Wisconsin (https://that.us/call-for-counselors/wi/2022/), July 25, 2022 VMware Explore 2022, August 29 – September 1, 2022 (https://www.vmware.com/explore.html?src=so_623a10693ceb7&cid=7012H000001Kb0hQAC) SpringOne Platform (https://springone.io/?utm_source=cote&utm_medium=podcast&utm_content=sdt), SF, December 6–8, 2022. SDT news & hype Join us in Slack (http://www.softwaredefinedtalk.com/slack). Get a SDT Sticker! Send your postal address to firstname.lastname@example.org (mailto:email@example.com) and we will send you free laptop stickers! Follow us on Twitch (https://www.twitch.tv/sdtpodcast), Twitter (https://twitter.com/softwaredeftalk), Instagram (https://www.instagram.com/softwaredefinedtalk/), LinkedIn (https://www.linkedin.com/company/software-defined-talk/) and YouTube (https://www.youtube.com/channel/UCi3OJPV6h9tp-hbsGBLGsDQ/featured). Use the code SDT to get $20 off Coté's book, (https://leanpub.com/digitalwtf/c/sdt) Digital WTF (https://leanpub.com/digitalwtf/c/sdt), so $5 total. Become a sponsor of Software Defined Talk (https://www.softwaredefinedtalk.com/ads)! Recommendations Brandon: tvOS 15.4 lets you finally log in to captive Wi-Fi portals on Apple TV (https://www.macworld.com/article/622912/tvos-15-4-features-release-install.html) Matt: The Poppy War (https://amzn.to/3LufOWD) Coté: Skilcraft U.S. Government Retractable Ball Point Pen, Fine Point, Blue Ink, Box of 12 (https://www.amazon.com/Skilcraft-Government-Retractable-Point-7520-01-332-3967/dp/B008UARY3I/). 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It's the final countdown... time to fire up the barbeque and get those democracy sausages sizzling, as we prepare to head to the polls to vote in the 2022 federal election (unless you're one of the 5 million super-organised Aussies who've already cast their ballot). But what if you haven't been particularly engaged in this election campaign, or you're still not sure who to vote for? Well, fear not, because The Quicky speaks to two experts in Australian politics to wrap this election up like the bread around your snag into one easily digestible episode, summarising everything you need to know before you number those boxes. Subscribe to Mamamia GET IN TOUCH Feedback? We're listening! Call the pod phone on 02 8999 9386 or email us at firstname.lastname@example.org CONTACT US Got a topic you'd like us to cover? Send us an email at email@example.com CREDITS Host: Claire Murphy With thanks to: Amy Remeikis - Guardian Australia's political reporter Mark Kenny - Australian Studies Professor at the Australian National University's College of Arts and Social Sciences, and host of the weekly politics and public affairs podcast, Democracy Sausage With Mark Kenny Producer: Claire Murphy Executive Producer: Siobhán Moran-McFarlane Audio Producer: Jacob Round Subscribe to The Quicky at...https://mamamia.com.au/the-quicky/ Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures. Just by reading our articles or listening to our podcasts, you're helping to fund girls in schools in some of the most disadvantaged countries in the world - through our partnership with Room to Read. We're currently funding 300 girls in school every day and our aim is to get to 1,000. Find out more about Mamamia at mamamia.com.au Support the show: https://www.mamamia.com.au/mplus/ See omnystudio.com/listener for privacy information.
On Episode 16 of the Stroke Alert Podcast, Dr. Negar Asdaghi highlights two articles from the May issue of Stroke: “Number of Affected Relatives, Age, Smoking, and Hypertension Prediction Score for Intracranial Aneurysms in Persons With a Family History for Subarachnoid Hemorrhage” and “Endovascular Treatment for Acute Ischemic Stroke With or Without General Anesthesia.” She also interviews Dr. Patrick Lyden on “The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results.” Dr. Negar Asdaghi: Let's start with some questions. 1) How is it that stroke can be cured in rodents but not in humans? 2) Are we wasting time or gaining time with general anesthesia before endovascular thrombectomy? 3) My father had an aneurysmal subarachnoid hemorrhage, Doctor. What is my risk of having an aneurysm, and how often should we check for one? We're back here with the Stroke Alert Podcast to tackle the toughest questions in the field because this is the best in Stroke. Stay with us. Dr. Negar Asdaghi: Welcome back to the May 2022 issue of the Stroke Alert Podcast. My name is Negar Asdaghi. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine and your host for the monthly Stroke Alert Podcast. For the May 2022 issue of Stroke, we have a number of papers that I'd like to highlight. We have seven articles as part of our Focused Update on the topic of neuroimmunology and stroke, organized by our own Stroke editors, Drs. Johannes Boltze and Miguel Perez-Pinzon. We also have an interesting study by Dr. David Saadoun and colleagues from Sorbonne University in Paris, where we learn that in patients with Takayasu disease, how the delay in diagnosis, as defined by the time from symptom onset to the diagnosis being over one year, was significantly associated with development of ischemic cerebrovascular events. In the Comments and Opinions section, we have an interesting study by Dr. Goldenberg and colleagues from University of Toronto on the benefits of GLP-1 receptor agonists for stroke reduction in type 2 diabetes and why should stroke neurologists be familiar with this new class of diabetic medication. Dr. Negar Asdaghi: Later, in the interview section of the podcast, I have the great honor of interviewing Dr. Patrick Lyden, one of the founding fathers of thrombolytic therapy in stroke, as he walks us through the Stroke Preclinical Assessment Network and what his hopes are for the future of stroke therapy. I also ask him for some advice, and he did tell us about the view from the top, as he truly stands on the shoulder of giants. But first with these two articles. Dr. Negar Asdaghi: In a landmark population-based study out of Sweden that was published in Brain in 2008, we learned that the odds of development of aneurysmal subarachnoid hemorrhage for individuals with one first-degree relative with a prior history of aneurysmal subarachnoid hemorrhage was 2.15. For individuals with two affected first-degree relatives, the odds ratio was 51. So, it's not surprising that a great deal of anxiety is caused within a family when a relative has an aneurysmal subarachnoid hemorrhage, especially if that family member was young or another member of the family had the same condition before. This scenario is commonly followed by a number of inevitable questions: Should all family members of the affected individual be screened for presence of an intracranial aneurysm? If yes, how often should vascular imaging be performed, and should other aneurysmal risk factors, such as age, sex, smoking, and hypertension, be also considered in the screening decision-making? In this issue of the journal, as part of a derivation-validation study, a group of investigators, led by Dr. Charlotte Zuurbier from University Medical Center at Utrecht Brain Center in the Netherlands, studied the ability of a simple scoring system that was developed in their derivation cohort to predict the presence of an intracranial aneurysm on vascular imaging. Dr. Negar Asdaghi: They then tested the scoring model in their validation cohort. So, for their development cohort, they used data on 660 persons who were screened at the University Medical Center for presence of an intracranial aneurysm because they had two or more affected first-degree relatives with a prior history of aneurysmal subarachnoid hemorrhage. The median age of participants at the time of first screening was 40, and 59% were female. Dr. Negar Asdaghi: So, in this cohort, the investigators simply looked at factors that were independently associated with finding an aneurysm on vascular screening by their multivariate analysis. And they identified the following factors; the first factor was the number of affected relatives. Now, a reminder that all of these people in the cohort had at least two first-degree relatives with an aneurysmal subarachnoid hemorrhage. And they found that amongst these people, those that had three or more family members with aneurysmal subarachnoid hemorrhage were significantly more likely to have a positive screening test for intracranial aneurysm. The next factor was older age — the older that relative, the more likely their screening imaging was positive for an aneurysm — and the other independent factors were smoking and hypertension. So they created the NASH acronym; N for number of relatives, A for age, S for smoking, and H for hypertension. When assigning points for each of these factors, the NASH scoring system had a C statistics of 0.68 in predicting whether or not someone would have a positive test, which is an intracranial aneurysm. Dr. Negar Asdaghi: And now a reminder for our listeners that C statistics gives us the probability that a person with a certain condition, in this case, a certain NASH score, will have the outcome of interest, in this case, an aneurysm found by vascular imaging. In general, for C statistics, the closer we get to 1, the more robust is our predictive model. Values over 0.7 indicate that we have a good model, but values over 0.8 indicate a very strong model. So the NASH score, at 0.68, has a reasonably good capability in predicting who will or will not have an intracranial aneurysm if we complete the vascular imaging. But it's not a very strong model, and this should be kept in mind. Let's look at some of their numbers. In their development cohort, the probability of finding an intracranial aneurysm for a person who scored low on NASH, that is a young person who never smoked and is not hypertensive, was only 5%, whereas the probability of finding an intracranial aneurysm in a person who scored high on NASH, that is an older person in their 60s or 70s, with three or more affected relatives, who is hypertensive and a smoker, was 36%. Dr. Negar Asdaghi: So, then they tested this NASH score in their external validation cohort and found that the likelihood of identifying an aneurysm increased as expected along the range of predicted probabilities of NASH. That is, the higher the score, the more likely to find an aneurysm on screening with vascular imaging. And the C statistics in the validation cohort was slightly lower than the C statistics in the derivation cohort. So, the important lesson we learned from this study is that the risk of having an intracranial aneurysm in a person who has a first-degree family member with a prior history of aneurysmal subarachnoid hemorrhage is substantially different depending on their NASH score, and this should be taken into consideration when deciding on screening and counseling various family members of the affected patient or prioritizing who should be screened first in routine practice. Dr. Negar Asdaghi: The ideal anesthetic management during endovascular therapy is still unknown. A number of studies have compared the different anesthetic options available during thrombectomy, which include general anesthesia, or GA, conscious sedation, use of local anesthesia, and no sedation at all. The main argument for doing endovascular therapy under general anesthesia is that although this procedure will take some precious pre-thrombectomy time, it does result in strict immobility. And that is really ideal in the sense that it improves catheter navigation and interpretation of angiography, in addition to obviously providing a secure airway and, of course, avoiding the need to have to do an emergency intubation in case of procedural complications. The argument against general anesthesia is not only the issue of time but also the risk of hypotension and hemodynamic compromise, especially during induction, and the loss of very valuable neurological examination in a completely sedated patient during the procedure. Dr. Negar Asdaghi: The question is, does general anesthesia improve or worsen neurological and functional outcomes post-thrombectomy? Several smaller randomized trials have looked at this very question, mainly comparing GA to all other forms of sedation during thrombectomy, but they have yielded inconsistent findings regarding the three-month functional outcome. Dr. Negar Asdaghi: Some of them showed that patients under GA ended up doing better. Some showed no difference in the overall outcomes. But overall, their pooled analysis suggested that GA might be superior to the competing counterpart, which is the conscious sedation, and associated with better functional outcome. But these centers had highly specialized anesthesia teams, and it's possible that their findings may not be generalizable to routine practice. So, in this issue of the journal, using the Swiss Stroke Registry, Dr. Benjamin Wagner from the Department of Neurology at the University Hospital in Basel and colleagues report on the outcomes of endovascularly treated patients in the Swiss Stroke Registry receiving thrombectomy for an anterior circulation stroke with or without general anesthesia. The primary outcome was disability on the modified Rankin Scale after three months. For this study, they excluded one out of the nine centers in the registry that had lots of missing data on their three-month follow-up. Dr. Negar Asdaghi: And so, from 2014 to 2017, 1,284 patients across eight stroke centers in the registry were included in this study. Sixty-six percent received thrombectomy under general anesthesia. On baseline comparison, the patients in the GA group were older, had a higher NIH Stroke Scale on admission, had worse preclinical functional status, and more likely to have presented with multi-territorial ischemic stroke. So, many reasons as to why people who underwent general anesthesia would have a worse clinical outcome in this study. So, now let's look at their primary outcome. In the unadjusted model, the three-month modified Rankin Scale was significantly worse in the GA group as compared to the non-GA group, which is obviously expected given the differences in their baseline characteristics. Dr. Negar Asdaghi: But what was surprising was that the odds of having a higher mRS score was significantly greater still in the adjusted models. They also did propensity score matching analysis, and they found that the NIH Stroke Scale after 24 hours, and the odds of dependency and death and mortality were all higher in the adjusted model in the GA group. They also looked at a number of secondary outcomes and found that door-to-puncture time was longer in the GA group. Dr. Negar Asdaghi: And also these patients were more likely to be transferred to ICU after treatment as compared to the non-GA treated counterparts. The authors point out that these real-world data are in keeping with the findings from the HERMES meta-analysis, which included over 1,700 endovascularly treated patients, and two previously published large registry data, one from Italy, which included over 4,000 endovascularly treated patients, and one from Germany, including 5,808 patients, all of them showing a worse functional outcome in endovascular therapy if the treatment was performed under general anesthesia, as compared to all other forms of sedation or no sedation at all. Again, these findings are in contrast with the reassuring results of the randomized trials on this topic, specifically in contrast to the AnStroke, SIESTA, and GOLIATH randomized trials, which compare GA to conscious sedation, showing either neutral or positive results in favor of general anesthesia pre-thrombectomy. Dr. Negar Asdaghi: So, in summary, what we learned from this real-world, observational study is that general anesthesia was associated with worse functional outcome post-endovascular thrombectomy, independent of other confounders, which means that the jury is still out on the ideal form of anesthesia for an individual patient prior to endovascular therapy, and we definitely need larger, multicenter studies on this topic. Dr. Negar Asdaghi: There are over a thousand experimental treatments that have shown benefit in prevention of neurological disability in animal models of ischemic stroke but have failed to show the same efficacy in human randomized trials. In fact, to date, reperfusion therapies, either in the form of intravenous lytic therapies or endovascular treatments, are the only successful treatments available to improve clinical outcomes in patients who suffer from ischemic stroke, and stroke remains a leading cause of death and disability worldwide. How come stroke can be cured in rodents but not in humans? Are neuroprotective therapies, or as more correctly referred to, the cerebroprotective therapies, the epitome of bench-to-bedside translational research failure? And if this is true, what are the key contributors to the scientific conundrum, and how can this be averted in the future? This is the question that a remarkable group of neuroscientists, led by Dr. Patrick Lyden from University of Southern California, are hoping to answer. Dr. Negar Asdaghi: In this issue of the journal, these investigators describe the rationale, design, feasibility, and stage 1 results of their multicenter SPAN collaboration, which stands for the Stroke Preclinical Assessment Network. I'm joined today by Professor Lyden himself to discuss this collaboration. Now, Professor Lyden absolutely needs no introduction to our stroke community, but as always, introductions are nice. So, here we go. Dr. Lyden is a Professor of Physiology, Neuroscience, and Neurology at Zilkha Neurogenetic Institute, Keck School of Medicine, at USC. He has truly been a leader in the field of preclinical and clinical vascular research with over 30 years of experience in conducting studies and randomized trials, including conducting the pivotal NINDS clinical trial that led to the approval of the first treatment for acute ischemic stroke in 1996. Throughout his exemplary career, he has accumulated many accolades and is the recipient of multiple awards and honors, including the prestigious 2019 American Stroke Association William Feinberg Award for Excellence in Clinical Stroke. Good morning, Pat, it's truly an honor to welcome you to our podcast today. Dr. Patrick Lyden: Thanks, I'm glad to be here. Dr. Negar Asdaghi: Well, in the era of successful reperfusion therapies, it seems that the new generation of stroke neurologists and interventionalists have their eyes, so to speak, on the clock and are interested in opening the blood vessels and opening them fast. In the age of reperfusion treatments, why do we still need to talk about the role of cerebroprotective treatments? Dr. Patrick Lyden: Well, not to sound too glib about it, but not everybody gets better after a thrombectomy. So, thrombectomy is good, it's more effective than anything else that we've tried before, but there are a remaining number of patients with a residual disability. Not only that, and from a more scientific standpoint, thrombectomy offers us the opportunity now to combine cerebroprotective therapy with known reperfusion. Remember, before, we didn't know when the artery had opened, but now we do an embolectomy, we know there's reperfusion. It gives us the opportunity to know that we're combining our treatment with reperfusion. Dr. Negar Asdaghi: So, in the paper, you discussed how hundreds of treatments have been studied and shown efficacy in reducing neurological disability in animal models of stroke, and yet failed in human studies. In your opinion, what were the top two most disappointing studies in terms of clinical failure despite pre-clinical encouraging data? Dr. Patrick Lyden: Well, the first one I mentioned was personal because it was the first one that I led, and it was a molecule called clomethiazole that I had helped establish the rationale for in my very first grant. So, it was the first trial I led, it was multinational, and, of course, I firmly believed we were going to hit a home run, and we failed. But to the field, the real watershed moment in neuroprotective therapy was the so-called SAINT II Trial. SAINT II was a study of a drug called NXY-059, and it was the first drug that purportedly had satisfied all of the so-called STAIR criteria. The STAIR criteria came out of a roundtable between academics and industry on how to best qualify drugs preclinically before going to human trials. And the idea was, if you were a 10 out of 10 on the STAIR criteria, then you should win when you come to human clinical trials. And the SAINT II Trial, which I was a co-leader, a co-investigator, on, also failed. Dr. Patrick Lyden: And so many, many, many drugs had failed by that point. Tens of millions, if not a hundred million dollars, had been spent by industry, and SAINT II really caused the field to stop. Industry stopped investing in stroke; academic investment in stroke dried up. NIH funding became more difficult to get after SAINT II, and that really was sort of the really historical low moment in the development of treatment for stroke. Dr. Negar Asdaghi: I was a resident when SAINT II came out, and I remember that somber feeling. Dr. Patrick Lyden: It was a sad day. Dr. Negar Asdaghi: Yeah. So, in the paper, you outline a number of potential causes as to why this translational failure may have occurred. But you highlighted the absence of preclinical scientific rigor as the most responsible source. And you already alluded to this a little bit. Can you please tell us a bit more? Dr. Patrick Lyden: Absolutely. And first, of course, we have to say that the ideal clinical trial design is not available. We really don't know the absolute best way to test the drugs in human clinical trials. But leave that for another day. Dr. Patrick Lyden: On the preclinical side, what can we say we're doing wrong? We're not sure, but one thing that has been highlighted over and over is that we don't approach preclinical characterization with as much rigor as we should. What do I mean by that? Animal models recapitulate for us some of the biology of a stroke, but not all. For example, many, many times we test a drug in a young model, an animal that's quite young, corresponding to a late teenager in human terms. Well, that's ridiculous. Stroke occurs in elderly people, and so on. So, the NIH called in a landmark conference for additional rigor, enhanced rigor. And I should mention the STAIR criteria were a first attempt at this. STAIR put out guidelines that said animals should be elderly, the animals should be randomized, et cetera, et cetera. And so that didn't happen. Although the STAIR criteria were out there, very few laboratories really committed to full rigor. And so the NIH funded the Stroke Preclinical Assessment Network, SPAN, to implement every aspect that we could think of that would add the best possible scientific design, the utmost rigor. So, we implemented true blinded assessment, true randomization, complete case ascertainment where we follow every single subject in the study and account for dropouts and subjects that don't complete the treatment, and, most importantly, a proper statistical design with adequate power and very large numbers. And the hypothesis that we're testing is that additional rigor in SPAN will lead to a better positive predictive value when we think about drugs that should go forward for testing in human stroke trials. Dr. Negar Asdaghi: So, I think you already answered my next question, which was basically, why do you think SPAN is going to achieve what all others have failed to achieve? But I wanted to simplify and repeat what you mentioned. So, in simple terms, what SPAN is trying to do is to bring all preclinical research to a level of scientific rigor that was not necessarily present and make it a multicenter effort. And can you a little bit tell us about the different stages, again, of SPAN? Dr. Patrick Lyden: Well, I'm not arguing that all preclinical research needs to be done following a SPAN type of model. Where SPAN fits in is at the end of a development project. So, if you want to characterize the cellular and molecular mechanisms, you don't need to do all of this rigor that we're doing. Just study the drug in the lab and do the mechanistic studies that need to be done. If you want to do dose finding, it doesn't need to be done this way. But at the end of that, OK, first we establish the mechanism, that's the first stage. Then we establish the toxicity. Then we establish target engagement. At the end, we are looking for some evidence that the drug will have a beneficial effect on outcomes. And in previous animal models, the only outcome, generally, the most common outcome that was studied, was size of the stroke. But in humans, the FDA does not recognize stroke size as a valid outcome. Dr. Patrick Lyden: We look at function, most often measured with the Rankin score and the NIH Stroke Scale. So, we had to create a functional outcome, and then we had to study it at multiple laboratories to make sure we could replicate the effect across multiple sites. And we chose what's called a multi-arm, multi-stage (MAMS) statistical design. All the drugs start out in the experiment at the end of the first interim analysis, which is 25% of the sample size. We cull any compounds or treatments that appear futile are removed. Any that appear effective move on. At the end of the second stage, there's more culling. There's a total of four stages, and we're about to enter stage four, by the way. That's starting next week. And in stage four, there will be, at most, two, maybe only one treatment that has appeared non-futile and possibly effective for final characterization. Dr. Negar Asdaghi: So, really interesting. I just want to highlight two important comments that you mentioned for our listeners again. So this is multi-layer, as you mentioned, multi-arm, multi-stages. It's sort of filter by filter, just ensuring that what we're seeing, the efficacy we're seeing in preclinical studies, will potentially be replicated in clinical studies. And what you mentioned that's very important is outcomes that classically is measured in animal models are infarct volume that are obviously very important but not necessarily may translate to exactly what we look at in clinical studies, which is functional outcomes, modified Rankin score and NIH Stroke Scale. So, with that, I want to then come back to the treatments that are actually being studied as part of SPAN. You have six very different agents as part of SPAN, from tocilizumab to uric acid. Why do you think these therapies will work? Dr. Patrick Lyden: Well, my job as the PI of the coordinating center is to remain completely agnostic to the treatments. So, everybody's equal, and they all come in on an equal playing field. We actually have a mechanical treatment called remote ischemic conditioning, as well, and then five drugs. And these were selected through a peer review process at NIH. And then we were informed at the coordinating center what drugs we would be studying. Five drugs and one treatment. And then, of course, the challenge to us was to somehow create a blinded, randomized situation. Now, this turned out to be a fascinating, it's more mechanical, but how do you blind when some of the drugs are given orally, some are given intraperitoneally, some are given intravenously, some are given once, some are given multiple times? So, we had to work with the manufacturers and inventors of these drugs and figure out a way to package them, and in the paper, actually, there's a photograph in the appendix that shows we had to find these bottles that were amber-colored and how to load them and lyophilize the drug. Dr. Patrick Lyden: And it's actually pretty fascinating how we were able to get all of these different, wildly different therapies, as you say, into a paradigm where they could be tested one against another in a truly blinded, truly randomized way. Dr. Negar Asdaghi: Do you think you can go on record and say which one is your favorite? Dr. Patrick Lyden: My favorite drug's not even in SPAN. I am truly agnostic because where my heart is, is with a drug that I've been studying in my laboratory completely separately and not part of SPAN. Dr. Negar Asdaghi: All right, so we don't have a favorite. So, in a recent review article in Stroke, you commented on treatments used by ancient Persians, Greeks, and Romans to remedy the brain affected by stroke and how the future generation of physicians will look back at our current practices of stroke with the same, how you said, awe and bemusement we hold for Galen, Aristotle, and Avicenna. How do you think stroke will be treated in the year 2222? Dr. Patrick Lyden: Well, first of all, and to be serious for just one moment, 200 years from now, I worry more about the climate than about medicine. And I really believe our biggest efforts need to be spent on saving the planet. But assuming we make it that long, obviously diagnostic methods will be completely different. Using ionizing radiation to scan the body will be laughed at by physicians in the future. There'll be detection technologies that aren't even on our radar yet today. And then treatments will be cellular focused and regionally focused. We give a drug through a vein and it circulates throughout the entire body, and I'm sure physicians in the future will find a way to somehow get treatment into the part of the body that's injured, not the whole body. And then, who knows? All we can say is they will laugh at us in the same way that we laugh at Theodoric the Barber of York. Dr. Negar Asdaghi: Let's move on from the future to the past. You're arguably one of the founding fathers of reperfusion therapies. You were instrumental in getting intravenous lytic therapy approved in 1996. It literally took the field 20 years for the next treatment to be approved, that's endovascular treatment. If you could go back in time and give your young self an advice on the subject of research, of course, design and execution, what advice would you give yourself? Dr. Patrick Lyden: Don't listen to old guys. We got a lot of advice from gray-bearded folks back when we were putting together the tPA trial, and fortunately we ignored some very bad advice and did what we imagined was the right thing to do as young, headstrong up-and-comers do. The other thing is, we really believed that by publishing our science very objectively, without editorial comment, we would be listened to. And that was dead wrong. So, the data was printed in the New England Journal in a very neutral tone, and we felt people would read that data and they would start using tPA the day after the publication. And, as you say, it took 20 years for tPA to really gain widespread acceptance, thrombolytic therapy. Today, people view it as standard, but it wasn't that way at the beginning. And I would say to myself and my colleagues at that time, "Don't be afraid to promote a positive result." Yes, it has to be done with the utmost rigor, but once you have a positive result, there will be plenty of people around pretending they know more than you and telling the world why you are wrong. And it's very important to stand up for your science and stand up for your results and say, no, no, no, no, that interpretation is wrong. The data says what we said it says, and this is an effective treatment and should be used, as an example. Dr. Negar Asdaghi: What a great advice. Just be bold and say it loud and stand up for your science. Pat, it's been a pleasure interviewing you and having you on the podcast. We really look forward to watching your research. Bring, let me say it again, 2222 closer to now. Dr. Patrick Lyden: Thank you. Glad to be here. Dr. Negar Asdaghi: Thank you. Dr. Negar Asdaghi: And this concludes our podcast for the May 2022 issue of Stroke. Please be sure to check out this month's table of contents for the full list of publications, including two articles on quality improvement in stroke and neurohospitalist—inpatient teleneurology, which comes as part of our Advances in Stroke series prepared by our section editors. And as we close our podcast today, let's take a moment and ask ourselves the same question that I asked Dr. Lyden earlier. What is the next frontier in stroke treatment? Past reperfusion therapies, we have to find ways to preserve the neurons and not just the neurons, all components of the brain. So, is the future of stroke therapy cerebroprotection? Ever since the dawn of history, humanity has lived alongside of death with the conscious apprehension that as we age, we lose the very gift of life. But unlike our ancestors, the search for immortality isn't the quest to find a fountain of youth anymore. We learned that death is inevitable, but with medicine, we can reduce illness and suffering to prolong a life worth living, one with a healthy brain. And today we're closer than ever to this modern immortality with cerebroprotection in stroke, as we stay alert with Stroke Alert. Dr. Negar Asdaghi: This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit AHAjournals.org.
We all go through moments of stress from having a lot on our plate. Our overly busy lives can prevent us from thinking clearly which doesn't allow us to make the best decisions. In this episode we learn about strategic inaction and how it can help us achieve more by doing less. As you listen I challenge you to think about how this can help you in your financial life. In this episode, Jinny Uppal, a business and tech growth strategist, board advisor and thought leader, shares with us her money memory that has impacted her to this day and what led her to write her book In/Action: Rethinking the Path to Results. What you'll learn about in today's episode: How we can stop the hustling but still be able to get ahead in our goals What a strategic pause is and why it matters The specific role the hustle culture plays on the great resignation For a quick recap of this episode go to http://www.jenhemphill.com/309 Want to get social? Let's connect more on Instagram @jenhemphill Grab your copy of My Daily Dinero Ritual and increase your money confidence here: https://jenhemphill.com/dinero The post, How a Strategic Inaction Can Help You to Achieve More by Doing Less | HDM 309 appeared first on the Her Dinero Matters Podcast.
Being ready to deal with failure and setbacks in trading is a key skill. Failing to deal with failure is going to destroy your mental and financial capital and make profitable trading impossible. In this podcast episode, I am proposing a different approach to dealing with setbacks. ################ My trading course bundle: ► https://ultimatepriceaction.com/ Edgewonk trading journal: ► https://www.edgewonk.com *** use discount code: tradeciety *** ################ ► Risk Disclaimer: https://www.tradeciety.com/risk-disclaimer/ Disclaimer: The experience reports and comments constitute the personal experiences of our users. These are individual results that do not permit conclusions to be drawn about future developments. In particular, we make no claim that these are typical results that can be achieved by our users on a regular basis. Tradeciety can neither predict nor guarantee the occurrence of certain developments or the achievement of profits nor will it do so. Results may not be typical and may vary from person to person. There are inherent risks involved with investing and trading, including the loss of your investment. Past performance in the market is not indicative of future results. Any investment is at your own risk. Connect with me My website: https://tradeciety.com/ My YouTube channel: https://www.youtube.com/tradeciety
In this episode of the Duct Tape Marketing Podcast, I interview Edward Sullivan. Edward has been coaching and advising start-up founders, Fortune 10 executives, and heads of state for over 15 years. His clients include executives from Google, Salesforce, Slack, and dozens of other fast-growth companies. He holds an MBA from Wharton and an MPA from the Harvard Kennedy School. Edward is CEO & President of the renowned executive coaching consultancy Velocity. He also has a new book launching on June 21, 2022, called — Leading With Heart: 5 Conversations That Unlock Creativity, Purpose, and Results. Links to resources: Leadingwithheartbook.com Take the Marketing Assessment: Marketingassessment.co
Nearly 75% of consumers want to be able to text with a business. But many businesses don't offer this mode of communication with their buyers. Aaron Weiche joins the show to talk about how businesses are using two-way text messaging to close more leads and generate conversations with buyers. In this episode, we cover: Where texting fits in the modern marketing funnel How two-way texting is different from LiveChat or other SMS tactics What kind of businesses would benefit from texting with buyers Results businesses can expect when adding texting as a communication channel What kind of buyers prefer texting with business The relationship between two-way texting and customer experience https://leadferno.com/blog/survey-how-do-consumers-want-to-contact-a-business
Results are in from primary elections in five states, including heated contests in North Carolina and Pennsylvania. And Elon Musk is expressing doubts about his $44 billion deal to buy Twitter. Shell-shocked residents of Buffalo, New York are reeling from the killings and still grappling with how to feel safe again, even after President Biden's visit during which he called for unity.
Ryan Blackburn breaks down the NBA Draft Lottery results as the Orlando Magic win the lottery and will select first overall in the 2022 NBA Draft. Ryan talks about the top teams and the top prospects before pivoting to the Nuggets and the initial players profiled at Denver Stiffs. Finally, Ryan discusses how important it is for the Nuggets to see the floor at a high level going forward to become a championship caliber team.
Circadian rhythm optimization can improve metabolic health and support longevity. Learn ways to match lifestyle interventions with your circadian clock. Crush your next workout or sauna session with the new Electrolyte Stix by MYOXCIENCE: https://bit.ly/electrolyte-stix Use code podcast to save 15% OFF at checkout Link to show notes and video: https://bit.ly/3a6Zo9D Time Stamps: 02:10 A dysregulated circadian clock system causes disease and dysfunction at the cellular level. 02:30 20%-50% of your protein synthesizing genes oscillate on a diurnal rhythm. 03:40 Disease alters the circadian clock system. 04:40 Blood sugar management supplements and pharmaceuticals would be best taken in the afternoon or evening, when blood sugar levels are most erratic. 05:03 Blood lipid level management supplements and pharmaceuticals would be best taken in the evening, when lipid synthesis occurs. 05:54 Decrease inflammatory tone before you go to sleep by doing some light yoga, breath work, take probiotics or curcuminoids. 07:30 Sleep perturbations cause dysbiosis in gut bacteria. 09:40 The intensity of your circadian rhythm is reduced as you age. 11:10 Circadian chronotypes influence the timing of cancer interventions. 12:00 N-acetylcysteine and other antioxidants are best taken in the evening or before bed. 12:40 Results of studies may be inaccurate due to timing. 15:20 Shift workers have a higher incidence of cancer, metabolic disease, and obesity. 14:50 Cold, food, heat, meal timing and exercise influence your circadian clock system. 17:20 Menopause challenges the circadian clock system, reducing the amplitude of the rhythms. 18:40 Young people/children's circadian rhythm is more light sensitive. Artificial light can be more problematic. 23:00 Fasting and feeding influence your circadian clock system. Break your fast between 11 and 1 pm when your digestive system is primed. 24:45 DHEA antagonizes cortisol's synthesis and expression. 28:05 Darkness is a circadian cue. Exercise light hygiene. 31:25 Morning cold exposure and evening heat exposure enhances circadian amplitude.
Circadian rhythm optimization can improve metabolic health and support longevity. Learn ways to match lifestyle interventions with your circadian clock. Crush your next workout or sauna session with the new Electrolyte Stix by MYOXCIENCE: bit.ly/electrolyte-stix Use code podcast to save 15% OFF at checkout Link to show notes and video: https://bit.ly/3a6Zo9D Time Stamps: 02:10 A dysregulated circadian clock system causes disease and dysfunction at the cellular level. 02:30 20%-50% of your protein synthesizing genes oscillate on a diurnal rhythm. 03:40 Disease alters the circadian clock system. 04:40 Blood sugar management supplements and pharmaceuticals would be best taken in the afternoon or evening, when blood sugar levels are most erratic. 05:03 Blood lipid level management supplements and pharmaceuticals would be best taken in the evening, when lipid synthesis occurs. 05:54 Decrease inflammatory tone before you go to sleep by doing some light yoga, breath work, take probiotics or curcuminoids. 07:30 Sleep perturbations cause dysbiosis in gut bacteria. 09:40 The intensity of your circadian rhythm is reduced as you age. 11:10 Circadian chronotypes influence the timing of cancer interventions. 12:00 N-acetylcysteine and other antioxidants are best taken in the evening or before bed. 12:40 Results of studies may be inaccurate due to timing. 15:20 Shift workers have a higher incidence of cancer, metabolic disease, and obesity. 14:50 Cold, food, heat, meal timing and exercise influence your circadian clock system. 17:20 Menopause challenges the circadian clock system, reducing the amplitude of the rhythms. 18:40 Young people/children's circadian rhythm is more light sensitive. Artificial light can be more problematic. 23:00 Fasting and feeding influence your circadian clock system. Break your fast between 11 and 1 pm when your digestive system is primed. 24:45 DHEA antagonizes cortisol's synthesis and expression. 28:05 Darkness is a circadian cue. Exercise light hygiene. 31:25 Morning cold exposure and evening heat exposure enhances circadian amplitude.
The "NEW" Revolutionary Hoodoo New Orleans Voodoo Secrets and Recipes Respect The Voodoo™ Psychics can predict But Hoodoo New Orleans Voodoo Secrets and Recipes get Results! www.HouseoftheDivinePrince.com DivinePrince@HouseoftheDivinePrince.com NOON US CST on Blog Talk Radio! Host | Member since Dec 23, 2008 Pan African Spiritualist Practitioner Author and Advisor I will be FORWARD (NOON US CST) with more Revolutionary Hoodoo New Orleans Voodoo Secrets and Recipes! ATR Spirituality and Religion from a Pan African Hoodoo World Spiritualist perspective. Listen in and Call in (And ALWAYS In-Archive at Your Leisure and Convenience) GUEST CALL-IN (515) 605-9718 https://www.BlogTalkRadio.com/The-Divine-Prince All is a Blessing! #RespectTheVoodoo
In This Podcast, Jim & Stewart Will Demystify the Reality of What It Takes for Today's Companies to Transform Tomorrow's Results. If You're Not Planning Your Future, Someone Else Is….Global Competition for Time, Talent & Treasure Are Changing Faster Than Ever Before So You Can't Afford to Be Left Behind. You Will Ride the Wave in Your Market or Get Crushed By its Force.It's Your Choice…Join Jim & Stewart and their guests for the ride of your life creating your future history!
THIS QUESTION CHANGED MY LIFE. In today's episode, I share my personal journey of going ALL IN, and making a huge career transition that's allowed me more focus, freedom, possibilities, and powerful RESULTS as I'm living my dreams every single day… IMAGINE. I couldn't be more grateful that I made the DECISION to IMAGINE...AND CHANGE. Stop waiting. Start creating. If not NOW…WHEN? What IF… Imagine what your life would look like IF you weren't so distracted? Please grab your SACRED S.O.L. D.A.T.E. JOURNAL (Daily Action To Engage yourself.) TODAY'S SACRED S.O.L. STEP: What is that longing that's been in your heart for so long? It's been asking, begging, quietly waiting to be recognized, and patiently waiting for you to turn to IT and say, YES YOU ARE my top priority. That's your dream. The desire of your heart. Your purpose. Your mission. Your future. Your LIFE. Are you willing to receive it fully, and say YES, you're my priority? Are you willing to make your heart, your heart's cry, your heart's song YOUR priority? Write down what that is for you. Contemplate it. Take a look at it. Then ask yourself: What IF I wasn't so distracted…IMAGINE what I could do? I'd love to hear from you, and would love to know what you just committed to... Thank you for being here, and allowing me to Sip On Life with you. If you've been feeling like you're stuck, overwhelmed, or perhaps you still feel like you're drowning in your life, please don't hesitate to reach out. YOU ARE NOT ALONE... Request a FREE copy of my best-selling book, Date Yourself Well — The Best-Selling 12 Engagements Of Becoming The Great Lover Of Your Life (all you'll pay for is shipping.) www.dateyourselfwell.com If you've received value from the podcast, please let me know. I'd LOVE to hear from you — please email me at: firstname.lastname@example.org AND PLEASE TELL YOUR BESTIES AND INVITE THEM TO SIP ON LIFE WITH US. FOLLOW ME ON INSTAGRAM @doctorshannon! See you there... And learn about an incredible opportunity for a select sacred group of 25 women who are ready and willing to RISE UP AND BE THE WOMAN. If you've been feeling like you're stuck, overwhelmed, or perhaps you still feel like you're drowning, please don't hesitate to reach out. I'd be more than happy to schedule a Discovery Call with you to see if Healing Life Coaching is a good fit for you. Email me at email@example.com Come over to the WOMEN SIPPING ON LIFE S.O.L. MOVEMENT Closed FB Group and Join the MOVEMENT: https://www.facebook.com/groups/WSOLMovement/ By the way, if you haven't already listened/downloaded my rap song (EPISODE 291), you can also listen to it here: letsnottalkaboutex.com, and cast your vote for your favorite version. Visit WomenSippingOnLife.com for more free resources, including my CHECKLIST FOR CHANGE, Engagement Checklist + Evaluation Rating, Six Sacred S.O.L. DATE Secrets…and a FREE copy of my best-selling book, Date Yourself Well. You can also check out my Dr. Shannon Facebook Pagefor more daily S.O.L. TRAINING. I look forward to seeing you again tomorrow. Please invite your best girlfriends to come and join our S.O.L. PARTY. xo Dr. Shannon. Inspiring minds that want to grow and hearts that want to know, so you can love you, your life, and your life's work well. ONE SIP AT A TIME. A special thanks to the following souls for helping me launch our WOMEN SIPPING ON LIFE podcast… Intro/Outro done by UNI V. SOL Outro music by Jay Man: Mind Over Matter (www.ourmusicbox.com) Podcast cover design and web site done by: Pablo Aguilar (www.webdesigncreator.com) Podcast cover photo by Kate Montague of KM Captured (www.kmcaptured.com)
Fully established in other fields, Product Management is finding its way into L&D. As an emerging discipline in L&D, Product Management is growing in prominence due to its focus on delivering demonstrable, meaningful results. Anne-Marie Burbidge has been applying the principles of PM to her L&D and as a successful Head of L&D has recruited for Product Managers. So what is it? How is it different? And is it better than traditional approaches at reaching desired outcomes? Find out in this episode. KEY TAKEAWAYS The training or resource you provide is your product. Taking a product approach to L&D, changes your mindset. The product management approach to L&D mirrors the way businesses work when serving external customers. Speak to your customers, and understand what their pain points are. Often, the questions people have that need answering first are incredibly basic e.g. how do I sign-on. Start fresh with each problem. Don´t rule any solution in or out. Recognise that transitions and change generate new questions and needs. If you have a backlog, tackle the issues that solve a problem for as many people as possible. Being through with your research and measuring the impact will slow you down initially. But over the long term, it will actually speed things up. Make sure that the resource is available at the point of need and can be used to easily find the answer to very specific questions. It'sts not about the input, it is about the output. BEST MOMENTS 'The product way of working is a mindset around how you do what you do.' 'A lot of the challenges occur at transition points…starting a new role, changes to the business.' 'Demonstrate to the business that you understand the problem. ' 'Once you know what the problem is, you can be laser-focused on solving that.' VALUABLE RESOURCES The Learning And Development Podcast - https://podcasts.apple.com/gb/podcast/the-learning-development-podcast/id1466927523 L&D Masterclass Series: https://360learning.com/blog/ EPISODE RESOURCES You can connect with Anne-Marie via: LinkedIn: https://www.linkedin.com/in/anne-marieburbidge/ ABOUT THE GUEST Anne-Marie is a Head of Learning & Development drawing on 15 years experience of running L&D teams. Anne-Marie is keenly interested in Agile principles and understanding how data can help us, using a range of tools and approaches to understand what's really going in order to grow capability and confidence effectively. Anne-Marie is a Head of Learning & Development drawing on 15 years experience of running L&D teams. Anne-Marie is keenly interested in Agile principles and understanding how data can help us, using a range of tools and approaches to understand what's really going in order to grow capability and confidence effectively ABOUT THE HOST David James David has been a People Development professional for more than 20 years, most notably as Director of Talent, Learning & OD for The Walt Disney Company across Europe, the Middle East & Africa. As well as being the Chief Learning Officer at 360Learning, David is a prominent writer and speaker on topics around modern and digital L&D. CONTACT METHOD Twitter: https://twitter.com/davidinlearning/ LinkedIn: https://www.linkedin.com/in/davidjameslinkedin/ L&D Collective: https://360learning.com/the-l-and-d-collective/ Blog: https://360learning.com/blog/ L&D Masterclass Series: https://360learning.com/blog/ See omnystudio.com/listener for privacy information.