Podcasts about blbc

BUFFALO, NY — December 1, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 11 of Aging-US was #published on October 30, 2025, titled “SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells.” In this study led by first author Ryan Wallis along with corresponding author Cleo L. Bishop, from Queen Mary University of London, researchers developed a machine learning tool to identify compounds that induce cancer cells into senescence. The tool, called SAMP-Score, offers a new strategy for drug discovery in cancers with poor treatment options like basal-like breast cancer. Senescence is a process where damaged or aged cells stop dividing. In cancer therapy, inducing senescence is an approach to control tumor growth. However, it is difficult to detect true senescence in cancer cells that already appear aged. These cancers, often called Sen-Mark+ cancers, include basal-like breast cancer and typically lack reliable markers to confirm senescence. SAMP-Score was designed to address this problem. Instead of relying on traditional markers, the researchers built a machine learning model trained to recognize patterns based on senescent cells' shape and structure under a microscope. These visual patterns, known as senescence-associated morphological profiles (SAMPs), allowed the model to distinguish real signs of aging from other effects such as toxicity or normal variation. By analyzing thousands of cell images, the model learned to classify whether a cell had truly entered senescence. “To demonstrate the potential application of SAMP-Score in p16 positive cancer therapeutic discovery, we assessed a diversity screen of 10,000 novel chemical entities in MB-468 cells (p16 positive BLBC).” The team used SAMP-Score to screen more than 10,000 experimental compounds. One compound, QM5928, consistently triggered senescence in several cancer cell types without killing them, making it a promising candidate for further study. Importantly, it worked in cancers resistant to known drugs like palbociclib, which are often ineffective in cancers with high p16 expression like basal-like breast cancer. Further analysis revealed that QM5928 caused the p16 protein to move into the nucleus of cancer cells, a possible sign that the protein is helping stop cell division. This subtle effect was only detectable using the detailed imaging and analysis made possible by SAMP-Score, highlighting the tool's ability to distinguish true senescence from toxic responses and making it a powerful resource in cancer drug discovery. By combining machine learning with high-resolution imaging, this study introduces a new way to find and evaluate cancer therapies. SAMP-Score could accelerate efforts to develop treatments that exploit the body's natural aging processes to fight cancer, especially for patients with resistant tumors. The tool is openly available at GitHub, making it accessible for other researchers exploring senescence-based cancer therapies. DOI - https://doi.org/10.18632/aging.206333 Corresponding author - Cleo L. Bishop - c.l.bishop@qmul.ac.uk Abstract video - https://www.youtube.com/watch?v=qXI_KI3EgHE Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Léta se pohybovala v mediálním světě. Svůj hlas propůjčila mimo jiné i Českému rozhlasu. Od mluveného slova se ale v posledních letech přesunula ke slovu psanému. Vydala už pět knih a chystá další. Jaké to je psát příběh vlastního dětství a jak se vyrovnat s pádem až na dno? I o tom mluvila spisovatelka a moderátorka Šárka Rosová Váňová.Všechny díly podcastu Až na dřeň můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Dnešní speciální vydání populárního pořadu nám to vysvětlí. Společnost je na tom prostě bídně. 

Možná mě odnesou z jeviště nohama napřed, říká operní pěvkyně a zpěvačka Dagmar Pecková, která nedávno oslavila šedesátku. Má za sebou bohatou kariéru, kterou si ale musela tvrdě vybojovat, deprese a vyhoření a teď taky střet s politiky a lidskou závistí. Lidem v Česku chce ukazovat krásu hudby, která jakoby ustupuje zábavě. V otevřeném rozhovoru popisuje své minulé i současné boje.

Starting as a cabin leader, Danny Johnston is now Bear Lake Bible Camp's director! Starting as the director in 2017, Danny has continued to see several successful summers of full camps full of kids. Looking to expand BLBC, they are now looking at plans to further expand the camp limits! Enjoy this hilarious, motivating, and inspiring conversation with Danny Johnston!

Consent Items: Motion, Vote, Appointed Additional Members to the Reed BLBC, Accepted a Briefing Report on Academic Support for Students from Pre-K to K12; Board Comments 1. Minutes: a. November 28, 2017 Work Session on The Facilities Student Accommodation Plan, the Fall Update and the Capital Improvement Plan Framework b. November 30, 2017 School Board Meeting c. January 19, 2018 Committee of the Whole Meeting 2. Personnel Actions 3. Briefing Reports: a. Academic Support, Pre-Kindergarten to Grade 12 Update 4. Building Level Planning Committee Appointments for New Elementary School at Reed

Mason Jar Press, a new, local independent press, brings together their authors in a celebration of literature and art. Join the authors of the most recent MJP publications—the Black Ladies Brunch Collective and Michelle Junot—for a reading, Q and A, and book signing. Hosted and moderated by MJP authors Stephen Zerance and Matthew Falk.Michelle Junot has kept notes on her phone for years—what to pick up at the store, work-out logs, prayers, hopes, thoughts on life and death—all the while creating a snapshot of her life with an honesty that only occurs when not paying attention. In Notes From My Phone(Mason Jar Press, 2016), Junot opens up her phone and her life to you. This collection of essays, to-do lists, vignettes, reminders and dreams mixes heart-felt memoir with the everyday marginalia that makes up a twenty-something’s life and day planner.The Black Ladies Brunch Collective’s poetry anthology, Not Without Our Laughter, (Mason Jar Press, 2017) is a collection of humorous and joyful poems, riffing on Langston Hughes’s novel Not Without Laughter. It explores topics of family, work, love and sexuality. The women of BLBC believe, like Hughes, that even in these currently tense racial times, laughter and the celebration of life is crucial. Historically, it is what African Americans have done and will continue to do, no matter what challenges face them. The Black Ladies Brunch Collective is Teri Cross Davis, Anya Creightney, Katy Richey, celeste doaks, Saida Agostini, and Tafisha Edwards. Edited by celeste doaks.Writers LIVE programs are supported in part by The Miss Howard Hubbard Adult Programming Fund.

Mason Jar Press, a new, local independent press, brings together their authors in a celebration of literature and art. Join the authors of the most recent MJP publications—the Black Ladies Brunch Collective and Michelle Junot—for a reading, Q and A, and book signing. Hosted and moderated by MJP authors Stephen Zerance and Matthew Falk.Michelle Junot has kept notes on her phone for years—what to pick up at the store, work-out logs, prayers, hopes, thoughts on life and death—all the while creating a snapshot of her life with an honesty that only occurs when not paying attention. In Notes From My Phone(Mason Jar Press, 2016), Junot opens up her phone and her life to you. This collection of essays, to-do lists, vignettes, reminders and dreams mixes heart-felt memoir with the everyday marginalia that makes up a twenty-something’s life and day planner.The Black Ladies Brunch Collective’s poetry anthology, Not Without Our Laughter, (Mason Jar Press, 2017) is a collection of humorous and joyful poems, riffing on Langston Hughes’s novel Not Without Laughter. It explores topics of family, work, love and sexuality. The women of BLBC believe, like Hughes, that even in these currently tense racial times, laughter and the celebration of life is crucial. Historically, it is what African Americans have done and will continue to do, no matter what challenges face them. The Black Ladies Brunch Collective is Teri Cross Davis, Anya Creightney, Katy Richey, celeste doaks, Saida Agostini, and Tafisha Edwards. Edited by celeste doaks.Writers LIVE programs are supported in part by The Miss Howard Hubbard Adult Programming Fund.Recorded On: Wednesday, April 19, 2017

...in which the Black Ladies Brunch Collective and i talk the state of joy, poetic resistance, and luther vandross... the BLBC on instagram: @blackladiesbrunchcollective celseste doaks' site: www.doaksgirl.com Twitter: @thedoaksgirl Instagram: @thedoaksgirl the next BLBC reading: http://calendar.prattlibrary.org/event/an_evening_with_mason_jar_press#.WNbsP-v3aK2 Not Without Our Laughter: http://www.masonjarpress.xyz/chapbooks-1/not-without-our-laughter-by-black-ladies-brunch-collective other things referenced: Grace Nichols - https://en.wikipedia.org/wiki/Grace_Nichols reading Hurricane Hits England - http://www.poetryarchive.org/poet/grace-nichols Derek Walcott - https://www.poetryfoundation.org/poems-and-poets/poets/detail/derek-walcott Cave Canem - http://cavecanempoets.org/ "won't you celebrate with me" by Lucille Clifton - https://www.youtube.com/watch?v=XM7q_DUk5wU Chris Abani - http://www.chrisabani.com/

Antoine Karnoub explains how increased expression of PTX3 promotes the growth of basal-like breast cancer cells.

Hello Reptile Radio fans! BT and CK kick off the Fourth of July weekend with a breeding season update. Some cool Ball Python production results, potentially tasty eggs in the incubator, interesting BLBC threads (including a beautiful bicephalic pastel ball python), summer hail in Kentucky, and lots of other bric-a-brac make up this episode. Tune in and check it out, and enjoy a little early summer R&R with the Double R!