Podcasts about CK

Join the C3 crew as they react to the Carolina Panthers playing their final home game in Bank of America Stadium against the Seattle Seahawks in week 17 of the NFL season!

It's time for our 2025 Solstice Special! The party has a sweet cozy time on the Solstice where absolutely nothing goes wrong. Just kidding. The CK would never let that happen! Vons feels a little stiff. Jyessi gets an unenviable designation. Wealthy faces an old foe. Check us out online! We're at https://www.primaryattribute.com

Canada's GDP went down in October, CK police say a woman was scammed out of $1,000, and we have the list of Christmas and Boxing Day opening and closings. All the noon headlines on the go.

Join the C3 crew as they react to the Carolina Panthers taking on the Tampa Bay Buccaneers at home and Bank of America Stadium for week 16 of the NFL season!

It's the most wonderful time of the year...This Sunday join Uncle Bill, CK and the Patrons as they discuss anything they damn well please...including a re-watch of the underseen (is it underrated?) Christmas Slasher from 1980 directed by David Hess, To All A Goodnight!!

In this episode of the Training Science Podcast, Dr. Martin Buchheit is joined by João Ribeiro, Head of Performance, to explore how elite football clubs monitor neuromuscular load and fatigue in real-world conditions.Building on their previous discussion around injury prevention and microcycle design, this conversation shifts focus to the response side of the monitoring equation—how athletes adapt to training and competition. João explains how his department integrates GPS data, wellness metrics, creatine kinase (CK), and low-frequency neuromuscular fatigue testing using Myocene to support daily decision-making, particularly during congested fixture periods.They discuss why passive, objective measures are essential when players cannot reliably perform maximal tests, how data is interpreted at the individual athlete level, and how monitoring is used to inform training availability rather than game selection.The episode also highlights feasibility, staff and coach alignment, and player buy-in as critical factors for successfully implementing advanced monitoring systems in applied football environments.ReferencesMyocene: https://www.myocene.com/Today's speakersDr. Martin Buchheit: https://martin-buchheit.net/João Ribeiro: https://www.linkedin.com/in/jo%C3%A3o-ribeiro-86997955

Sam is on with some conspiracies and fining out about the human condition, plus i S#ck Joe Rogan's D!CK

Tonight, the C3 Panthers Podcast crew discuss…-Dave Canales decision to not call a QB sneak with Bryce Young on 4th & 1-What Carolinas defensive struggles mean for Ejiro Evero going forward-How former Panthers QB's Baker Mayfield and Sam Darnold stand between Carolina and a home playoff game-How the Panthers can rebound at home against the Tampa Bay Buccaneers

Tonight the C3 crew discuss…-Jaycee Horn's 2nd consecutive Pro bowl nomination-Derrick Brown's egregious Pro bowl snub-Rico Dowdle making history for an undrafted RB-if the Panthers are primed to win the NFC South-Previewing the week 17 match against the Seattle Seahawks and MORE

Hello and Welcome to your Week 15 Recap from FGH!!! CK crushed it again with a 12-7 week and a +500 ATD parlay win on top of that!!! Go sign up at patreon.com_betfgh today!! Thanks for tuning in!!!Sponsored by www.texastelehealth.com

Hello and Welcome to your Week 15 Recap from FGH!!! CK crushed it again with a 12-7 week and a +500 ATD parlay win on top of that!!! Go sign up at patreon.com_betfgh today!! Thanks for tuning in!!! Sponsored by www.texastelehealth.com

Join the C3 crew as they react to the Carolina Panthers taking on the New Orleans Saints and the Mercedes-Benz Superdome in week 15 of the NFL season!

Can the Carolina Panthers maintain 1st place in the NFC South? Can the Panthers have the division locked up by week 16? Are the New Orleans Saints Carolinas toughest test left on the schedule? Which Panthers player is a MUST RESIGN in the off-season?

Tonight on the C3 Panthers Podcast the crew discuss it…-If the Carolina Panthers are a legit playoff contender-Austin Corbett Walter Payton man of the year nominee-Jaycee Horn tops Pro Bowl votes at corner-Saints playing top 5 defense since over the past month-Carolina maintaining momentum out of the bye

What if our universe is the inside of a black hole… inside another black hole? Neil deGrasse Tyson and Paul Mecurio answer a grab bag of fan questions about black hole mergers, the misconception about gravity assists, and if there's such a thing as laws of physics.NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free.Thanks to our Patrons Beth, Rebecca Yoswein, Leigh, Desiree Doporto, Bao Le, Thomas Alvarez, Eric Venus, Max And Gaz, Angel, Rebecca Schatz, Micheal Booth, Bruce Walton Jr, Rhea Rosier, Blake Rottmann, Patrick Clark, Cap, Paul Porter, Matthew Walton, Tiffany Brown, Brenda Eaves, Nash Bosworth, Billy Smith, Mike, Frenchy (Michael French), Teddy Funk, Randall Napier, Mary Zoellner, Carl L. Blackwell, Boris Barberic, Dexter Blackman, Joel Barjon, Kev, Abhay Joshi, Catherine Mary Darensbourg, Dav W, Brian Loop, cryHAVOC884, Daniel Bernal, Brian Page, Brendon Dougherty, hello hello is this thing on, Randy, Mary, Max, lo-res file, "CK" with th maual curly quotes, Draszje, David Szacik, Jason Nowak, Charlie Waddell, Danielle Taylor, Guillermo Gonzales, Gary in SD, Ohana, Jesse Abelson, Alex Nijman, Thorigrim, Peter J. Kushar, Kerry Lamb, Lengua Franca, Pamela Diane Carls, Jon, L Moore, RobbaYaga, Vilius Kazakauskas, Bjorn Nelson, Bob Watson, Shawn, MadWarrior, Devin, Brady Tomberlin, Micheal McEvoy, Pat, Kevin B, Tyler, Blaine Willick, Matthew CRessman, Zac, Julius Chatterjee, and Rigel Lopez for supporting us this week. Subscribe to SiriusXM Podcasts+ to listen to new episodes of StarTalk Radio ad-free and a whole week early.Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The OPP say three alleged impaired drivers were arrested Friday in Lakeshore, a CK woman's coffee rage has led to an assault charge, and US President Trump is now hinting at tariffs on Canadian fertilizer. All the evening headlines on the go.

Chatham-Kent police assisted the OPP after a report of a man holding a handgun in a vehicle on St. Clair Road in Wallaceburg. CK police are asking for the public's help in identifying a man believed to be involved in a theft at a store on Pioneer Line. A viral social media post is shining a light on a local cop. Fewer than 100 homes were sold in Chatham-Kent last month, well below recent November averages. A new "express entry" category for foreign-trained doctors is opening up. U.S. President Donald Trump seems non-committal when it comes to trade talks with Canada.

Will the Carolina Panthers pick up Bryce Young's 5th year option? How many Panthers players will make the Pro Bowl? Will Tetairoa McMillan when the OROY? Which NFL teams are the most dangerous to see in the playoffs? Will the Panthers win the NFC South?

Show Track List: Mirko & Meex - There's A Light (Extended Mix) Cruise Music Michael Gray & Definite Grooves feat Dyanna Fearon - The Spirit Moves - Extended Mix. Sultra Sonic Soul Orchestra feat. Mishell Ivon - One Love (Extended Mix) King Street Sounds Elios Aristide - Salome. Ohmelya Music Platform Play: Danny Coleman pres. Voices Of Light ft. Aneta Moran - Peace In The Valley - Extended Mix. Phoenix Soul Stacy Kidd, Tiffany Jenkins - Fallin (Remix) (Main Remix) House 4 Life The Sexy 3: Bellaire - Jazzed Up. AOC Records YANN!CK, Aurelie Morn - Grey Days (Extended Mix) Deeptown Music J.D.'s Time Machine, Cleveland P. Jones, Neil Pierce - Kiss Of Freedom (Neil Pierce Remix) Quantize Recordings Sgt Slick - Make It Happen (Extended Mix) Vicious Fouk - Get It Done. Freerange Michele Chiavarini - 1 World (Sean Mccabe Remix) Quantize Recordings 2013 Wattsy D3EP Thursday Night Hot Mix: FDF (Italy) - Disco Ball (Original Mix) THE KEY! Agent Stereo - Freaky People. La Casa Recordings Risk Assessment, Monica Blaire, Grant Nelson - It-s Not Right But It-s Okay (Grant Nelson Remix) Trimtone - Different Kind Of Music (Original Mix) In It Together Records Adri Block, Scotty Boy - Keep The Dance Floor Goin' (Original Mix) PornoStar Records (US) JOHNICK - Timmy's Party Groove (REMASTER) Muggsy The Rewind Selecter: Love To Infinity - Pray For Love. Mushroom 1996 Urban Blues Project pres. Michael Procter - Deliver Me (Dave Lee 2003 Z mix) Feel The Rhythm 2003 One Foot In The Grave ft. Vernon Lewis - Only You (The Groove Soulful Mix) Dervish feat Mike Davis & Inaya Day - Blessed (Richard Earnshaw Mix) Deepless Records 2008

TONIGHT the C3 crew discusses:-Bryce Young's big bounce back game-Carolina rediscovering running the football-Tetairoa McMillan odds to be the OROY-Panthers Pro Bowl candidates-Robert Hunt's potential return-Adam Thielen waived by Vikings and acquired by Steelers

Join the C3 crew as they react to the Carolina Panthers taking on the Los Angeles Rams in Bank of America Stadium for week 13 of the NFL season!

Infinite Plane Radio Broadcast: November 23rd, 2025This broadcast provided an analysis of current media narratives and political events, framing them as components of the broader Psyop Entertainment Complex designed to maintain a controlled worldview through a media duopoly, predictive programming, and reinforcement messaging.The Media Duopoly and Controlled OppositionThe media operates via a duopoly: "Mainstream and alt-mainstream. But the two are triangulated against one another".Pundits like Candace Owens, despite having the "number one podcast in the world", are seen as "controlled opposition".Her role is to serve as a bridge, redirecting followers from questioning media (red pill) into specific political narratives (J pill)."No, she got her start with Project Veritas. I mean, this is all just controlled opposition.""She's a bridge from red pill to J pill where, yeah, these conspiracies aren't really true. The real truth is this.""Candace Owens is leading people down well-paved rabbit trails."Charlie Kirk (CK) Event as a Staged PsyopThe purported assassination of Charlie Kirk (CK) is viewed as a "staged Psyop" or "magic show".The CK event was "likely planned, at least scheduled... in the mid-90s".The narrative structure involves three phases: "predictive programming", "concurrent programming" (e.g., Charlie Sheen discussing JFK assassination on Joe Rogan just before the CK news), and "reinforcement programming" (Candace Owens dominating the topic)."I think that politics... needs to be looked at as part of the Psyop entertainment complex.""The assumption that people die in Psyops" is described as a "guardrail" that prevents people from viewing media fakery in its entirety. Predictive Programming and Monolithic SymbolismHistorical events are forewarned through "predictive programming," acting as "product placement for future fake events".This manipulative worldview is described as "monolithic," drawing parallels to the monolith in 2001 Space Odyssey. The monolith represents "the ubiquitous worldview that is a merging of real and fake. Hyper-reality...".The concept of a "design authority" or "Saturnian presence" is linked to figures like the Man in Black in Westworld and Ed Harris's character in The Truman Show, who controls time and space."I look at it as product placement for future fake events.""I think what he's giving away with that movie is that we are being moved into this space odyssey.""The design authority, the meta-scripters, they are the Saturnian presence here.""If you can plot a timeline and plan in advance 30 years prior to major historically significant events, you control time."Color and Archetypal Symbolism (Green/Joker)The color green is frequently associated with class warfare and left-wing revolutionary archetypes.The Wicked Witch in Wicked is described as "100 antifa coded", rebelling against a "fascist wizard of oz".The Joker archetype is highlighted as a "class warrior" linked to "kill the rich" themes."So the Joker is accosted by some rich guys on a subway, and he kills them. And he's now a hero.""The green beret, the Joker, kill the rich, kill the CEOs. This is like a building theme..."

**Infinite Plane Radio Broadcast: November 23rd, 2025**This broadcast provided an analysis of current media narratives and political events, framing them as components of the broader **Psyop** Entertainment Complex designed to maintain a controlled worldview through a media duopoly, predictive programming, and reinforcement messaging.* **The Media Duopoly and Controlled Opposition** * The media operates via a duopoly: "Mainstream and alt-mainstream. But the two are triangulated against one another". * Pundits like Candace Owens, despite having the "number one podcast in the world", are seen as "controlled opposition". * Her role is to serve as a bridge, redirecting followers from questioning media (red pill) into specific political narratives (J pill). * "No, she got her start with Project Veritas. I mean, this is all just controlled opposition." * "She's a bridge from red pill to J pill where, yeah, these conspiracies aren't really true. The real truth is this." * "Candace Owens is leading people down well-paved rabbit trails."* **Charlie Kirk (CK) Event as a Staged Psyop** * The purported assassination of Charlie Kirk (CK) is viewed as a "staged **Psyop**" or "magic show". * The CK event was "likely planned, at least scheduled... in the mid-90s". * The narrative structure involves three phases: "predictive programming", "concurrent programming" (e.g., Charlie Sheen discussing JFK assassination on Joe Rogan just before the CK news), and "reinforcement programming" (Candace Owens dominating the topic). * "I think that politics... needs to be looked at as part of the **Psyop** entertainment complex." * "The assumption that people die in **Psyops**" is described as a "guardrail" that prevents people from viewing media fakery in its entirety. * "So now the dominant narratives on this topic are saturated with the alt media perspective clashing with the mainstream. And that's it." * "But the assumption that they're dead is sort of a, it's a guardrail."* **Political Theater and Societal Control** * The entire political system is characterized as "bread and circuses" designed to give "subjugated populations" an "illusion of power". * The political horseshoe split maintains division, enforced by provocateurs. * QAnon is described as a "cult" involving a "syncretic blend of Christianity and politics". * "I think MAGA's on the way out. I think it served its purpose." * "It's clear to me... that there's such a heavy-handed control over worldview that it constitutes a monopoly..." * "I mean, you have to recognize the effectiveness of this systemic media fakery and manipulation of worldview through the fabrication of historic events."* **Predictive Programming and Monolithic Symbolism** * Historical events are forewarned through "predictive programming," acting as "product placement for future fake events". * This manipulative worldview is described as "monolithic," drawing parallels to the monolith in *2001 Space Odyssey*. The monolith represents "the ubiquitous worldview that is a merging of real and fake. Hyper-reality...". * The concept of a "design authority" or "Saturnian presence" is linked to figures like the Man in Black in *Westworld* and Ed Harris's character in *The Truman Show*, who controls time and space. * "I look at it as product placement for future fake events." * "I think what he's giving away with that movie is that we are being moved into this space odyssey." * "The design authority, the meta-scripters, they are the Saturnian presence here." * "If you can plot a timeline and plan in advance 30 years prior to major historically significant events, you control time."* **Color and Archetypal Symbolism (Green/Joker)** * The color green is frequently associated with class warfare and left-wing revolutionary archetypes. * The Wicked Witch in *Wicked* is described as "100 antifa coded", rebelling against a "fascist wizard of oz". * The Joker archetype is highlighted as a "class warrior" linked to "kill the rich" themes. * "So the Joker is accosted by some rich guys on a subway, and he kills them. And he's now a hero." * "The green beret, the Joker, kill the rich, kill the CEOs. This is like a building theme..."* **The Nature of Reality and Disbelief** * The mainstream perspective often equates to the information provided by systems like "Wikipedia or chat GPT". * True skepticism is based on "informed disbelief," achieved by examining all sides, rather than "low information belief". * Psychological operations are only effective because "empathic people weren't being triggered and emotionally manipulated". * "The reason she's number one is she's propped up. I don't think it's organic." * "If your sole frame of reference is your seat and what the magician tells you to lo

TONIGHT join the C3 crew as they discuss…-The incredibly bipolar performances from Bryce Young-How much Dave Canales is to blame for Monday night's loss-Rico Dowdle's frustration with his lack of use-Jaycee Horn's 2 INT night and subsequent concussion-Isaiah Simmons potential impact on the defense-Preview the week 13 matchup with the LA Rams

Sofia Lopes high school champion girls hurdler decides what college shes going to live on the show with CK

Dystrophinopathies are heritable muscle disorders caused by pathogenic variants in the DMD gene, leading to progressive muscle breakdown, proximal weakness, cardiomyopathy, and respiratory failure. Diagnosis and management are evolving areas of neuromuscular neurology. In this episode, Kait Nevel, MD, speaks with Divya Jayaraman, MD, PhD, an author of the article "Dystrophinopathies" in the Continuum® October 2025 Muscle and Neuromuscular Junction Disorders issue. Dr. Nevel is a Continuum® Audio interviewer and a neurologist and neuro-oncologist at Indiana University School of Medicine in Indianapolis, Indiana. Dr. Jayaraman is an assistant professor of neurology and pediatrics in the division of child neurology at the Columbia University Irving Medical Center in New York, New York. Additional Resources Read the article: Dystrophinopathies Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @IUneurodocmom Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Nevel: Hello, this is Dr Kate Nevel. Today I'm interviewing Dr Divya Jayaraman about her article on dystrophinopathies, which she wrote with Dr Partha Ghosh. This article appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Divya, welcome to the podcast, and please introduce yourself to the audience. Dr Jayaraman: Thank you so much, Dr Nevel. My name is Divya, and I am an assistant professor of Neurology and Pediatrics at Columbia University Irving Medical Center, and also an attending physician in the Pediatric Neuromuscular program there. In that capacity, I see patients with pediatric neuromuscular disorders and also some general pediatric neurology patients and also do research, primarily clinical research and clinical trials on pediatric neuromuscular disorders. Dr Nevel: Wonderful. Thank you for sharing that background with us. To set us on the same page for our discussion, before we get into some more details of the article, perhaps, could you start with some definitions? What comprises the dystrophinopathies? What are some of the core features? Dr Jayaraman: So, the dystrophinopathies, I like that term because it is a smaller subset from the muscular dystrophies. The dystrophinopathies are a spectrum of clinical phenotypes that are all associated with mutations in the DMD gene on chromosome X. So, that includes DMD---or, Duchenne muscular dystrophy---, Becker muscular dystrophy, intermediate muscular dystrophy (which falls in between the two), dilated cardiomyopathy, asymptomatic hyperCKemia, and manifesting female carriers. In terms of the core features of these conditions, so, there's some variability, weakness being prominent in Duchenne and also Becker. The asymptomatic hyperCKemia, on the other hand, may have minimal symptoms and might be found incidentally by just having a high CK on their labs. They all will have some degree of elevated CK. The dilated cardiomyopathy patients, and also the Becker patients to a lesser degree, will have cardiac involvement out of proportion to skeletal muscle involvement, and then the manifesting carriers likewise can have elevated CK and prominent cardiac involvement as well as some milder weakness. Dr Nevel: Now that we have some definitions, for the practicing neurologists out there, what do you think is the most important takeaway from your article about the dystrophinopathies? Dr Jayaraman: I like this question because it suggests that there's something that, really, any neurologist could do to help us pick up these patients sooner. And the big takeaway I want everyone to get from this is to check the CK, or creatine kinase, level. It's a simple, cheap, easy test that anyone can order, and it really helps us a lot in terms of setting the patient on the diagnostic odyssey. And in terms of whom you should be thinking about checking a CK in, obviously patients who present with some of the classic clinical features of Duchenne muscular dystrophy. This would include young boys who have toe walking, as they're presenting, sign; or motor delayed, delayed walking. They may have calf hypertrophy, which is what we say nowadays. You might have seen calf pseudohypertrophy in your neurology textbooks, but we just say calf hypertrophy now. Or patients can often have a Gowers sign or Gowers maneuver, which is named after a person called Gowers who described this phenomenon where the child will basically turn over and use their hands on the floor to stand up, usually with a wide-based gait, and then they'll sort of march their hands up their legs. That's the sort of classic Gowers maneuver. There are modified versions of that as well. So, if anyone presents with this classic presentation, for sure the best first step is to check a CK. But I would also think about checking a CK for some atypical cases. For example, any boy with any kind of motor or speech delay for whom you might not necessarily be thinking about a muscle disorder, it's always good practice to check a CK. Even a boy with autism for whom you may not get a good clinical exam. This patient might present to a general pediatric neurology clinic. I always check a CK in those patients, and you'll pick up a lot of cases that way. For the adult folks in particular, the adult neurologist, a female patient could show up in your clinic with asymptomatic hyperCKemia. And I think it's an important differential to think about for them because this could have implications not just for their own cardiac risks, but also for their family planning. Dr Nevel: So, tell us a little bit more about the timing of diagnosis. Biggest takeaway: check a CK if this is anywhere on your radar, even if somewhat of an atypical case. Why is it so important to get kiddos started on that diagnostic odyssey, as you called it, early? Dr Jayaraman: This is especially important for kids because if they especially get a Duchenne muscular dystrophy diagnosis, you might be making them eligible for treatments that we've had for some time, and also treatments that were not available earlier that hinge on making that diagnosis. So, for example, people may be skeptical about steroids, but there's population data to suggest that initiation and implementation of steroids could delay the onset of loss of ambulation as much as three years. So, you don't want to deprive patients of the chance to get that. And then all the newer emerging therapies---which we'll be talking about later, I'm sure---require a Duchenne muscular dystrophy diagnosis. So, that's why it's so important to check a CK, have this on your radar, and then get them to a good specialist. Dr Nevel: I know that you alluded already, or shared a few of the kind of exam paroles or findings among patients with dystrophinopathy. But could you share with us a little bit more how you approach these patients in the clinic who are presenting with muscle weakness, perhaps? And how do you approach this or think about this in terms of ways to potentially differentiate between a dystrophinopathy versus another cause of motor weakness or delay? Dr Jayaraman: It's helpful to think through the neuraxis and what kinds of disorders can present along that neuraxis. A major differential that I'm always thinking about when I'm seeing a child with proximal weakness is spinal muscular atrophy, which is a genetic anterior horn cell disorder that can also present in this age group. And some of the key differences there would be things like reflexes. So, you should have dropped reflexes in spinal muscular atrophy. In DMD, surprisingly, they might have preserved Achilles reflexes even if their patellar reflexes are lost. It may only be much later that they go on to lose their Achilles reflex. So, if you can get an Achilles reflex, that's quite reassuring, and if you cannot, then you need to be thinking about spinal muscular atrophy. They can both have low muscle tone and can present quite similarly, including with proximal weakness, and can even have neck flexion weakness. So, this is an important distinction to make. The reason for that is, obviously there are treatments for both conditions, but for spinal muscular atrophy, timing is very, very important. Time is motor neurons, so the sooner you make that diagnosis the better. Other considerations would be the congenital muscular dystrophies. So, for those that they tend to present a lot younger, like in infancy or very early on, and they can have much, much higher CKS in that age range than a comparable Duchenne or Becker muscular dystrophy patient. They can also have other involvement of the central nervous system that you wouldn't see in the dystrophinopathies, for example. My mnemonic for the congenital muscular dystrophies is muscle-eye-brain disease, which is one of the subtypes. So, you think about muscle involvement, eye involvement, and brain involvement. So, they need an ophthalmology valve. They can have brain malformations, which you typically don't see in the dystrophinopathies. I think those are some of the major considerations that I have. Obviously, it's always good to think about the rest of the neuraxis as well. Like, could this be a central nervous system process? Do they have upper motor neuron signs? But that's just using all of your exam tools as a neurologist. Dr Nevel: Yeah, absolutely. So, let's say you have a patient in clinic and you suspect they may have a dystrophinopathy. What is your next diagnostic step after your exam? Maybe you have an elevated CK and you've met with the patient. What comes next? Dr Jayaraman: Great question. So, after the CK, my next step is to go to genetics. And this is a bit of a change in practice over time. In the past we would go from the CK to the muscle biopsy before genetic testing was standard. And I think now, especially in kids, we want to try and spare them invasive procedures where possible. So, genetic testing would be the next step. There are a few no-charge, sponsored testing programs for the dystrophinopathies and also for some of the differential diagnosis that I mentioned. And I think we'll be including links to websites for all of these in the final version of the published article. So, those are a good starting point for a genetic workup. It's really important to know that, you know, deletions and duplications are a very common type of mutation in the DMD gene. And so, if you just do a very broad testing, like whole exome, you might miss some of those duplications and deletions. And it's important to include both checking for duplications and deletions, and also making sure that the DMD gene is sequenced. So always look at whatever genetic test you're ordering and making sure that it's actually going to do what you want it to do. After genetics, I think that the sort of natural question is, what if things are not clear after the genetics for some reason? We still use biopsy in this day and age, but we save it for those cases where it's not entirely clear or maybe the phenotype is a little bit discordant from the genotype. So, for mutations that disrupt the reading frame, those tend to cause Duchenne muscular dystrophy, whereas mutations that preserve the reading frame tend to cause Becker muscular dystrophy. There are some important exceptions to this, which is where muscle biopsy can be especially helpful in sorting it out. So, for example, there are some early mutations early in the DMD gene where, basically, they find an alternate start codon or an initiation codon to continue with transcription and translation. So, you end up forming a largely functional, somewhat truncated protein that gives you more of a milder Becker phenotype. On the other hand, you can have some non-frameshift or inframe mutations that preserve the reading frame, but because they disrupt a very key domain in the protein that's really crucial for its function, you can actually end up with a much more severe Duchennelike phenotype. So, for these sorts of cases, you might know a priori you're dealing with them, but might just be a child who is who you think has DMD has a mutation that's showed up on testing. There isn't enough in the literature to point you one way or another, but they look maybe a little milder than you would expect. That would be a good kid to do a biopsy in because there are treatment decisions that hinge on this. There are treatments that are only for Duchenne that someone with a milder phenotype would not be eligible for. Dr Nevel: So, that kind of stepwise approach, but maybe not all kids need a muscle biopsy is what I'm hearing from you. If it's a mutation that's been well-described in the literature to be fitting with Duchenne, for example. Dr Jayaraman: Absolutely. Dr Nevel: So, after you confirm the diagnosis through genetic testing---and let's say, you know, whether or not you do a muscle biopsy or not, after you know the diagnosis is a dystrophinopathy---how do you counsel the families and your patients? What are the most important points to relay to families, especially in that initial phase where the diagnosis is being made? Dr Jayaraman: This is a lot of what we do in pediatric neurology in general, right? So, I actually picked up this approach from the pediatric hematology oncology specialists at Boston Children's. They had this concept of a day-zero conversation, which is the day that you disclose the life-changing diagnosis or potentially, at some point, terminal diagnosis to a family. And some of the key components of that are a not beating around the bush, telling them what the diagnosis is, and then letting them have whatever emotional response they're going to have in the moment. And you may not get much further than that, but honestly, you want them to take away, this is what my child has. I did not do anything to cause this, nor could I have done anything to prevent this. Because often for these genetic conditions, there's a lot of guilt, a lot of parental guilt. So, you want to try and assuage that as much as possible. And then to know that they're not going to be alone on this journey; that, you know, they don't have to have it all figured out right then, but we can always come back and answer any questions they have. There's going to be a whole team of specialists. We're going to help the family and the kid manage this condition. Those are sort of my big takeaways that I want them to get. Dr Nevel: Right. And that segues into my next question, which is, who is part of that team? I know that these teams that help take care of people with dystrophinopathies and other muscle disorders can be very large teams that span multiple specialists. Can you talk a little bit more about that for this group of patients? Dr Jayaraman: Of course. So, the neuromuscular neurologist, really, our role is in coordinating the diagnosis, the initiation of any disease-specific treatments, and coordinating care with a whole group of specialists. So, we're sort of at the center of that, but everyone else is equally important. So, the other specialists include physical therapists; occupational therapists; rehab doctors or physiatrists; orthotists who help with all of the many braces and other devices that they might need, wheelchairs; pulmonology, of course, for managing the respiratory manifestations of this. It becomes increasingly important over time, and they are involved early on to help monitor for impending respiratory problems. Cardiac manifestations, this is huge and something that you should be thinking about even for your female carriers, the mother of the patient you're seeing in the clinic, or your patient who comes to adult clinic with asymptomatic hyperCKemia. if you end up making a diagnosis of DMD carrier for those patients, or if you make a Becker diagnosis, the cardiac surveillance is even more important because the cardiac involvement can be out of proportion to the skeletal muscle weakness. And of course, extremely important for the Duchenne patients as well. Endocrinologists are hugely important because in the course of treating patients with steroids, we end up giving them a lot of iatrogenic endocrinologic complications. Like they might have delayed puberty, they might have loss of growth, of height; and of course metabolic syndrome. So, endocrinology is hugely important. They're also important in managing things like fracture prevention, osteoporosis, prescribing bisphosphonates if necessary. Nutrition and GI are also important, not just later on when they might need assistance to take in nutrition, whether that's through tube feeds, but also earlier on when we're trying to manage the weight. Orthopedics, of course, for the various orthopedic complications that patients develop. And then finally, a word must be said for social work and behavioral and mental health specialists, because a lot of this patient population has a lot of mental health challenges as well. Dr Nevel: After you give the diagnosis, you've counseled the patient and families and you've had those kind of initial phase discussions, the day-zero discussion, when you start getting into discussions or thoughts about management, disease-specific medication. But what are the main categories of the treatment options, and maybe how do you kind of approach deciding between treatment options for your patients? Dr Jayaraman: So, there are two broad categories that I like to think about. So, one is the oral corticosteroids and oral histone deacetylase, or HDAC inhibitors, which share the common characteristic that they are non-mutation specific. And within corticosteroids, patients now have a choice between just Prednisone or Prednisolone, or Deflazacort or Vermilion. The oral HDAC inhibitors are newly FDA-approved as a nonsteroidal therapy in addition to corticosteroids in DMD patients above six years of age. I would say we're in the early phase of adoption of this in clinical practice. And then the other big category of treatment options would be the genetic therapies as a broad bucket, and this would include gene therapy or gene replacement therapy, of which the most famous is the microdystrophin gene therapy that was FDA-approved first on an accelerated approval basis for ages four to eight, and then a full approval in that age group as well as an accelerated approval for all comers, essentially, with DMD. This is obviously controversial. Different centers approach this a bit differently. I think our practice at our site has been to focus on the ambulatory population, just thinking about risk versus benefit, because the risks are not insignificant. So really this is something that should be done by experienced sites that have the bandwidth and the wherewithal to counsel patients through all of this and to manage complications as they arise with regular monitoring. And then another class that falls within this broader category would be the Exon-skipping therapies. So as the name suggests, they are oligonucleotides that cause an Exon to be skipped. The idea is, if there is a mutation in a particular Exon that causes a frame shift, and there's an adjacent Exon that you can force skipping of, then the resulting protein, when you splice the two ends together, will actually allow restoration of the reading frame. I think the picture I want to paint is that there's a wide range of options that we present to families, not all of which everyone will be eligible for. And they all have different risk profiles. And I really think the choice of a particular therapy has to be a risk-benefit decision and a shared decision-making process between the physician and the family. Dr Nevel: What is going on in research in this area? And what do you think will be the next big breakthrough? I know before we started the recording you had mentioned that there's a lot of things going on that are exciting. And so, I'm looking forward to hearing more. Dr Jayaraman: Of course. So, I'll be as quick as I can with this. But I mentioned that next-generation Exon skipping therapies, I think the hope is that they will be better at delivering the Exon skipping to the target tissue and cells and that they might be more efficacious. I'm also excited about next-generation gene therapies that might target muscle more specifically and hopefully reduce the off-target effects, or combination use of gene therapies with other immunosuppressive regimens to improve the safety profile and maybe someday allow redosing, which we cannot do currently. Or potentially targeting the satellite cells, which are the muscle stem cells, again, to improve the long term durability of these genetic therapies. Dr Nevel: That's great, thank you for sharing. Thank you so much for talking to me today about your article. I really enjoyed learning more about the dystrophinopathies. Today I've been interviewing Dr Divya Jayaraman about her article on the dystrophinopathies, which she wrote with Dr Partha Ghosh. This article appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Please be sure to check out the Continuum Audio episodes from this and other issues. Also, please read the Continuum articles for more details than what we were able to get to today during our discussion. Thank you, as always, so much to the listeners for joining us today, and thank you, Divya, for sharing all of your knowledge with us today. Dr Jayaraman: Thank you so much for having me on the podcast. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Does prayer make a difference? After all, if God knows everything about us, then why should we bother praying? Kaitlyn helps us understand how prayer is more than listing our requests, but an opportunity to experience relationship with a Father who delights to hear from His kids, reshaping our desires, and drawing us into dependence on Him.   0:00 - Theme Song   0:23 - Sponsor - World Relief - Partner with World Relief in creating safety, stability and belonging for refugees and immigrants. A $200,000 Challenge Gift is multiplying every donation—give today at https://www.worldrelief.org/KAITLYN   2:50 - What's the Point of Prayer If God Knows Everything?   7:00 - God and Relationship   13:52 - Sponsor - Dwell - Listen to scripture throughout your day. Go to https://www.dwellbible.com/CK for 25% off!   14:37 - Sponsor - Hiya Health - Go to https://www.hiyahealth.com/CURIOUSLY to receive 50% off your first order   16:33 - God Likes Us   21:25 - Prayers Aren't Magic   26:00 - Wanting the Right Things   29:05 - Being With God Daily   34:37 - End Credits

Join the C3 crew as they react to the Carolina Panthers taking on the San Francisco 49ers on Monday night football in Levi's stadium for week 12 of the NFL season!

Can You Identify the Nation-State Actor?​​​​‌ ‍ ​‍​‍‌‍ ‌ ​‍‌‍‍‌‌‍‌ ‌‍‍‌‌‍ ‍​‍​‍​ ‍‍​‍​‍‌  ​ ‌‍​‌‌‍ ‍‌‍‍‌‌ ‌​‌ ‍‌​‍ ‍‌‍‍‌‌‍ ​‍​‍​‍ ​​‍​‍‌‍‍​‌ ​‍‌‍‌‌‌‍‌‍​‍​‍​ ‍‍​‍​‍‌‍‍​‌ ‌​‌ ‌​‌ ​​‌ ​ ​ ‍‍​‍ ​‍ ‌‍‍‌‌‍ ‍‌ ‌​‌‍‌‌‌‍ ​​ ‌​​ ‌ ​ ​‌​‍ ‍‌ ​ ‌‍​‌‌‍ ‍‌‍‍‌‌ ‌​‌ ‍‌​‍ ‍‌ ​ ‌ ‌​‌ ‌‌‌‍‌​‌‍‍‌‌‍ ​‍ ‌‍‍‌‌‍ ‍‌ ‌​‌‍‌‌‌‍ ‍‌ ‌​​‍ ‌‍‌‌‌‍‌​‌‍‍‌‌ ‌​​‍ ‌‍ ‌‌‍ ‌‍‌​‌‍‌‌​ ‌‌ ​​‌ ​‍‌‍‌‌‌ ​ ‌‍‌‌‌‍ ‍‌ ‌​‌‍​‌‌ ‌​‌‍‍‌‌‍ ‌‍ ‍​ ‍ ‌‍‍‌‌‍‌​​ ‌‌‍‌‍​ ‍​‌‍‌‍​ ​‌​ ‌​‌‍​‍​ ‍‌‌‍​‌​‍ ‌‌‍‌‍​ ​‍‌‍​‌​ ‌‌​‍ ‌​ ‌​‌‍‌​​ ​​​ ‍‌​‍ ‌​ ‍‌​ Out of the Woods: The Threat Hunting Podcast returns for another special edition episode that challenges how you think about adversary behavior. This live, interactive session will focus on a nation-state actor, revealing one phase of their campaign at a time as our hosts provide tradecraft clues and analysis.​​​​‌ Participants will examine how observed techniques align to MITRE ATT&CK, how vertical-specific targeting shapes operational decisions, and how behavioral patterns emerge across campaigns. Before the final reveal, attendees will have the chance to submit their best guess on which nation-state threat actor is behind the activity.​​​​‌ What You'll Learn:​​​​‌ ‍ ​‍​‍‌‍ ‌ ​‍‌‍‍‌‌‍‌ ‌‍‍‌‌‍ ‍​‍​‍​ ‍‍​‍​‍‌ ​ ‌‍​‌‌‍ ‍‌‍‍‌‌ ‌​‌ ‍‌​‍ ‍‌‍‍‌‌‍ ​‍​‍​‍ ​​‍​‍‌‍‍​‌ ​‍‌‍‌‌‌‍‌‍​‍​‍​ ‍‍​‍​‍‌‍‍​‌ ‌​‌ ‌​‌ ​​‌ ​ ​ ‍‍​‍ ​‍ ‌‍‍‌‌‍ ‍‌ ‌​‌‍‌‌‌‍ ​​ ‌​​ ‌ ​ ​‌​‍ ‍‌ ​ ‌‍​‌‌‍ ‍‌‍‍‌‌ ‌​‌ ‍‌​‍ ‍‌ ​ ‌ ‌​‌ ‌‌‌‍‌​‌‍‍‌‌‍ ​‍ ‌‍‍‌‌‍ ‍‌ ‌​‌‍‌‌‌‍ ‍‌ ‌​​‍ ‌‍‌‌‌‍‌​‌‍‍‌‌ ‌​​‍ ‌‍ ‌‌‍ ‌‍‌​‌‍‌‌​ ‌‌ ​​‌ ​‍‌‍‌‌‌ ​ ‌‍‌‌‌‍ ‍‌ ‌​‌‍​‌‌ ‌​‌‍‍‌‌‍ ‌‍ ‍​ ‍ ‌‍‍‌‌‍‌​​ ‌‌‍‌‍​ ‍​‌‍‌‍​ ​‌​ ‌​‌‍​‍​ ‍‌‌‍​‌​‍ ‌‌‍‌‍​ ​‍‌‍​‌​ ‌‌​‍ ‌​ ‌​‌‍‌​​ ​​​ ‍‌​‍ ‌​ ‍‌​ ​‍‌‍‌‍​ ‌ ​‍ ‌​ ​‍​ ‍‌​ ‌‌‌‍​‍‌‍​‍‌‍‌‍‌‍‌‌​ ‍‌‌‍‌‍​ ‌​​ ​‍​ ‍‌​ ‍ ‌ ‌​‌ ‍‌‌ ​​‌‍‌‌​ ‌‌ ​​‌‍ ‌‍‌​‌‍​ ‌‍​‌‌ ​ ‌ ‌​​ ‍ ‌ ​​‌‍​‌‌ ‌​‌‍‍​​ ‌‌ ​​‌‍​‌‌‍‌ ‌‍‌‌‌​​‍‌ ‌‌‌‍‍‌‌‍ ​‌‍‌​‌‍‌‌‌ ​‍​‍‌‌​ ‌‌‌​​‍‌‌ ‌‍‍ ‌‍‌‌‌ ‍‌​‍‌‌​ ​ ‌​‌​​‍‌‌​ ​ ‌​‌​​‍‌‌​ ​‍​ ​‍‌‍‌​‌‍​‌‌‍‌‌​ ​​‌‍‌‍​ ​‍‌‍​ Real adversary behavior – A phase-by-phase look at a real nation-state campaign MITRE ATT&CK in context – How techniques appear in real incidents​​​​‌ ‍ ​‍​‍‌‍ ‌ ​‍‌‍‍‌‌‍‌ ‌‍‍‌‌‍ ‍​‍​‍​ ‍‍​‍​‍‌ ​ ‌‍​‌‌‍ ‍‌‍‍‌‌ ‌​‌ ‍‌​‍ ‍‌‍‍‌‌‍ ​‍​‍​‍ ​​‍​‍‌‍‍​‌ ​‍‌‍‌‌‌‍‌‍​‍​‍​ ‍‍​‍​‍‌‍‍​‌ ‌​‌ ‌​‌ ​​‌ ​ ​ Recognizing tradecraft patterns – What links behaviors across operations​​​​‌ ‍ ​‍​‍‌‍ ‌ ​‍‌‍‍‌‌‍‌ ‌‍‍‌‌‍ ‍​‍​‍​ ‍‍​‍​‍‌ ​ ‌‍​‌‌‍ ‍‌‍‍‌‌ ‌​‌ ‍‌​‍ ‍‌‍‍‌‌‍ Sector-specific targeting – How industries influence attacker decisions​​​​‌ ‍ ​‍​‍‌‍ ‌ ​‍‌‍‍‌‌‍‌ ‌‍‍‌‌‍ ‍​‍​‍​ ‍‍​‍​‍‌ ​ ‌‍​‌‌‍ ‍‌‍‍‌‌ ‌​‌ ‍‌​‍ ‍‌‍‍‌‌‍ ​‍​‍​‍ ​​‍​‍‌‍‍​‌ ​‍‌‍‌‌‌‍‌‍​‍​‍​ ‍‍​‍​‍‌‍‍​‌ ‌​‌ Interactive analysis – Submit your guess before the reveal​​​​‌ Watch the episode here: https://youtu.be/GyYTTMNyjCE?si=WynwmHS1psGN9KqO

拿到普發一萬想出國？ Saily eSIM是你的好幫手

TONIGHT on the C3 Panthers Podcast the C3 crew discuss…-If Bryce Young has FINALLY proven himself to be THE franchise QB for the Carolina Panthers-If Tetairoa McMillan is the front runner for Offensive Rookie of the Year-What's changed Carolinas offense from the Saints to the Falcons-In the Panthers being a half game behind the Tampa Bay Buccaneers-Steve Smith Sr VS Pacman Jones-PLUS C3 previews the Carolina Panthers Monday Night Football match up against the San Francisco 49ers

The discussion from November 19, 2025, focuses on the concept of meta-scripted history and the difference between recognizing “noise” and identifying genuine signals within the mainstream media infrastructure. The core premise is that major historic events that shape the collective worldview are largely staged, fake, and planned decades in advance, making the “manufactured history and progress” the “only real conspiracy”.The speaker posits that the masses, including conventional “truthers,” are deceived into viewing engineered events as real, ongoing stories. These events are often “glitches in the matrix” that should be viewed as puzzle pieces to be systematized and analyzed as part of a “cohesive whole” because the patterns reveal something “formulaic”.Synopsis of Key ConceptsThe current media landscape is described as a “psyop entertainment complex,” operating as a mechanism for conforming the audience rather than informing them. This system fosters a state of confusion and ambiguity (”fog of sci war”) that prevents discernment.A significant portion of the conversation addresses media personalities and events used to negatively brand countermedia or anti-media movements. For instance, figures like Candace Owens and Tucker Carlson are seen as provocateurs running “performances”. The “CK thing,” related to Charlie Kirk, is viewed as manufactured, showing how easily the masses are deceived. The event itself is analyzed for its specific components, noting parallels like “everything about CK mirrors JFK” and the manufactured perception surrounding Erica Kirk. Furthermore, VP Kirk in the film Heads of State being shot in the neck mirrors the specific injury in the staged Kirk event.A crucial distinction is drawn between meaningful connections and noise generators. Noise includes practices like Kabbalistic gematria numerology, where individuals “ascribe significance to number combinations that have sixes in them” based on the incoherent methodology of drawing targets around hits while ignoring misses (the sharpshooter fallacy). These distractions “add noise to what we are doing” and lead people into “mysticism and confusion”.The deep structure of media fakery is highlighted by drawing historical parallels, such as the idea that Shakespeare's plays were a “government operation and a meta script to kind of shape the English psyche” and consolidate power, similar to modern news media. This concept suggests that the state creates myths for mass manipulation, a template seen from ancient religions (like Caesar's Messiah) to contemporary media.Ultimately, recognizing the engineered reality reduces the stress and fear often prevalent in “Trutherville,” allowing for an optimistic outlook despite the “closed informational system”.Talking Points (Bullet Points)The Only Real Conspiracy is Manufactured History: Large-scale historical events (e.g., the Dick Cheney death, 9/11 crash, the CK event) are systematically staged and become embedded into our collective historical narratives.Media Function is Conformity, Not Information: The media acts as a “state church” providing a universal worldview, with popular science providing the “miracles” and news media providing the “myths”. The media's purpose is to conform you, not inform you.Identifying and Eliminating Noise: Practices like calculating gematria values (e.g., Elon Musk being 16,606 days old when visiting the White House) are noise, distracting from rational analysis by pointing to “the usual suspects by design” through mysticism.The Danger of Ambiguity: Truthtellers who claim “I don't know if it's real or fake” are essentially admitting they are confused and lack discernment, having been successfully targeted by the media.Use of Predictive Programming and Templates: Staged events are preceded by entertainment media saturation to condition audiences and make the events seem “inevitable”. Examples include the Kyle Rittenhouse name correlating with “Rittenhouse Rye” and “Catcher in the Rye”, and Erica Kirk being modeled after Erica Matfield Kirk (Madame X), the Florida Governor's wife from 1967–1971.The Political Sphere as Entertainment: Politics is often characterized as “World Wrestling Entertainment,” serving as a steam valve for the population and a waste of “bandwidth,” suggesting a fundamental powerlessness for the populace (”patience in an open air asylum”).Direct Quotes“It just it shows you how how utterly deceived, the masses are, and this includes the truthers.”“No. They're manufacturing these conspiracies. It's just at this point, it's part of the mass media infrastructure.”“Actually, no. It's only a distraction if you don't know what to do with it.”“We have been putting the puzzle pieces together, and they're part of a cohesive whole. They're interrelated. The commonalities between them matter because you're looking at something formulaic.”“If this is how it really is... it suggests that we are, completely powerless and ess

Join the C3 crew as they react to the Carolina Panthers taking on the Atlanta Falcons in Mercedes-Benz Stadium for week 11 of the 2025 NFL season!

The not-so-mad DJ is back to talk 'bout Japan: the band and the country – as the winds then shift to Akiko Yano and YMO. CK-1 keeps bringing up Duran Duran, for some reasons, and I hope you like clips, because this is our clippiest to date. A voice screams from heaven. 0:00: Mayo Intro 0:08: Band of the Rising Sun 0:25: Obligatory Song Countdown 5-4 0:34: Commercial Break 0:36: Countdown 3-1 1:15: New "Romantic" Outro CLIPLIST: Japan – Still Life In Mobile Homes / Japan – Cantonese Boy / Japan – Adolescent SAX / Japan – The Experience of Swimming / Japan – Sons of Pioneers / Japan – Methods of Dance / Masami Tsuchiya – Secret Party / David Sylvian & Ryuichi Sakamoto – Bamboo Music / David Sylvian & Ryuichi Sakamoto – Forbidden Colors / Japan – The Art of Parties / Japan – Swing / Japan – Life In Tokyo / Japan – The Other Side of Life / (Misc. Commercials) / Japan – Ghosts / Japan – Quiet Life / Japan – European Son / Simon & Garfunkel – The Only Living Boy In New York / Japan – Visions of China / Men Without Hats – Living In China / Japan – Taking Islands in Africa / Japan – Methods of Dance / Japan – Gentlemen Take Polaroids / Japan – Still Life In Mobile Homes / David Sylvian – Pulling Punches / Rain Tree Crow – Rain Tree Crow / The Dolphin Brothers – Pushing The River / Mick Karn – Sensitive / Gary Numan – Slowcar To China / Akiko Yano – Sleep On My Baby / Akiko Yano – Goodnight / Akiko Yano – David / Yellow Magic Orchestra – Be A Superman / Thomas Dolby – Radio Silence / Yellow Magic Orchestra – Rydeen / Yukihiro Takahashi – Something In The Air / Yukihiro Takahashi – Flashback / ABC – Tears Are Not Enough / ABC – Valentine's Day / Japan – Still Life In Mobile Homes Our Email: 80ofthe80s@gmail.com Our Website: 80ofthe80s.com

Tonight, the C3 crew discuss if Bryce Young is whats holding the Panthers offense back, how much did Dave Canales trust his starting QB, why "victory Mondays" had such a negative effect on the teams preparedness, and preview the week 11 match up against the Atlanta Falcons!

Join the C3 crew as they react to the Carolina Panthers taking on the New Orleans Saints in Bank of America Stadium for week 10 of the NFL season!

Always good when Compton AV stops by the studio w CK and Carmen!

Tonight, the C3 crew discuss Ikem Ekwonu's shutdown day against Micah Parsons and the likelihood of him getting paid soon, the effectiveness of the offense continuing to run through Rico Dowdle, Preview this week's match up against the Saints, and interview Panthers super fan Carolina_Mic!

Join the C3 crew as they react to the Carolina Panthers traveling north to Lambeau Field to take on the Green Bay Packers in week 9 of the NFL season!

Join the C3 crew as they discuss the timetable for injured Panthers O linemen, If Carolina would have beat Buffalo with Bryce Young under center, the Panthers chances against the Green Bay Packers and YOUR catcalls at 252-228-5098!

Why don't Christians talk about the Holy Spirit more often? Have we quietly replaced dependence on God's Spirit with confidence in our own smarts and systems? What starts as a kid's Halloween question about the "Holy Ghost" quickly turns into a bigger conversation about why the church is so divided, whether we'd even notice if the Spirit disappeared from our theology, and how we might learn to let God surprise us again. After all, the Holy Ghost isn't here to haunt us, but to make us alive. 0:00 - Theme Song 0:19 - Sponsor - Dwell - Listen to scripture throughout your day. Go to https://www.dwellbible.com/CK for 25% off! 3:03 - Is the Holy Ghost Real? 6:33 - What Even is the Holy Ghost? 11:18 - How the Holy Ghost Helps Us 16:30 - Sponsor - Hiya Health - Go to https://www.hiyahealth.com/CURIOUSLY to receive 50% off your first order 18:18 - Sponsor - Hello! My Name is Emmanuel - A Heartwarming children's book about a Haitian child learning to trust God by Emmanuel Jean Russell https://a.co/d/8fPoRCL 19:15 - But why a "ghost?" 26:30 - What's the Takeaway? 33:21 - End Credits

Join Lia and Megan as we do 5 minutes (yep, we brought out the timers—Not Today, procrastination!) of hot takes on each member. What have they been up to? What might be Yet to Come? From Dior to medical centers, from CK to Celine...and of course comeback. This episode is pure Dynamite, so get ready to Run with us.Join The BTS Buzz and get access to Afternoona Army's exclusive DISCORD channel, get shout outs on-air in podcast, and receive invitations to quarterly live support groups. Questions? Email afternoonaarmy@gmail.com for more information.Are your family and friends sick of you talking about K-drama? We get it...and have an answer. Check out our sister pod www.afternoonadelight.com for more episodes, book recs and social media goodness. And don't forget about the newest members of our network: Afternoona Asks where diaspora Asians living in the West find ways to reconnect to Asian culture via Asian/KDramas.Want to find more great BTS content? Head over to Afternoona Army for more takes on Bangtan life and links to our social media.

Join the C3 crew as they react to the Carolina Panthers taking on the Buffalo Bills in Bank of America Stadium for week 8 of the NFL season!

Join the C3 crew as they discuss the Panthers chances of beating the mighty Buffalo Bills without Bryce Young. Can Andy Dalton shoulder the load with Bryce Young on the bench? Is this one of the stingiest run defenses in Carolinas history? Are the Panthers proving to be one of the hardest teams to face in the NFC? Is the NFC South ripe for the taking?

Join the C3 crew as they react to the Carolina Panthers taking on the New York Jets on the road in MetLife Stadium in week 7 of the NFL season!

Tackle High-Yield Concepts for USMLE Step 2 CK Cardiology This interactive session, led by Dr. Abraham Titus (Hematology/Oncology Fellow, University of South Alabama) and ScholarRx’s Jeff Downing, focuses on challenging USMLE Step 2 CK cardiology questions that will sharpen your clinical decision-making skills and deepen your understanding of cardiovascular medicine. WHAT YOU’LL LEARN: In this episode, we work through four board-style questions using our proven systematic approach that helps you think like a clinician first, then a test-taker second. You’ll learn how to apply clinical guidelines and make evidence-based management decisions through detailed explanations that go beyond just identifying the correct answer. Topics Covered: Cardiovascular risk management and pharmacotherapy Acute coronary syndrome management strategies Peripheral vascular disease evaluation and treatment Secondary hypertension workup and management Perfect for: Medical students preparing for USMLE Step 2 CK Clinical year medical students on cardiology rotations IMGs studying for board exams Anyone looking to strengthen their cardiology clinical reasoning Review the full test: https://usmle-rx.scholarrx.com/share/1do75erd2wnmg0y Free Resources: Biochemistry Course: https://usmle-rx.com/biochemistry-course/ More Rx Bricks Podcasts: https://usmle-rx.com/podcast Study Planner: https://go.usmle-rx.com/study-schedule/

In this episode of Real Life Pharmacology, we take a deep dive into daptomycin, a lipopeptide antibiotic primarily used for serious Gram-positive infections, including MRSA and VRE. Daptomycin works by binding to bacterial cell membranes in a calcium-dependent manner, causing rapid depolarization and cell death. One key limitation is that daptomycin should never be used for pneumonia because pulmonary surfactant inactivates the drug. Clinically, it's often reserved for bacteremia, endocarditis, or complicated skin and soft tissue infections. From a pharmacokinetic standpoint, daptomycin is given intravenously and primarily eliminated unchanged by the kidneys, so dose adjustments are necessary in renal impairment. Monitoring creatine kinase (CK) levels is crucial, as one of the major adverse effects is myopathy and, rarely, rhabdomyolysis. Patients on statins have a higher risk of muscle toxicity, and clinicians should consider holding or monitoring statin therapy closely. Eosinophilic pneumonia is another rare but serious adverse reaction that can develop after prolonged therapy. Daptomycin has minimal drug interactions, making it an appealing option when other agents pose risks. Overall, it's a powerful antibiotic when used appropriately, but requires careful monitoring for muscle and respiratory-related side effects.

She sold her advertising agency to write stories about the fierce, overlooked women who built America. CK Van Dam's debut novel, Proving Her Claim, has already won two Spur Awards and immerses readers in a frontier romance as bold and expansive as the Dakota plains themselves. In this episode, CK shares the inspiration behind her “On the Dakota Frontier” series, why she chose to spotlight unconventional heroines like Anna Olson, and how historical fiction can challenge the myths we've been told about the American West. If you're looking for adventure, romance, and action all woven into a powerful story of resilience and reinvention, you won't want to miss this conversation. Quotes: “History is full of women who were strong, resourceful, and too often forgotten.” “Romance on the frontier wasn't just about love—it was about survival.” “Fiction lets us reimagine the past and reclaim voices that history left out.” Resources: Follow CK Van Dam on Facebook Connect with CK Van Dam on LinkedIn On the Dakota Frontier

This week, Kaitlyn tackle a kid's big question: “I know there's one true God, but are there little gods beneath him?” From Psalm 82 to Job and Paul, the Bible's language about gods, angels, demons, and spiritual powers is stranger than most of us realize. Kaitlyn unpacks what these passages mean, why scripture sometimes blurs the line between human rulers and spiritual beings, and how it all points back to the hope that the one true God reigns above every power.   Holy Post Plus: My Hill to Die On: Red Letter Bibles: https://www.patreon.com/posts/my-hill-to-die-138522925   0:00 - Theme Song   0:58 - Are There Little gods in the Bible?   3:26 - Psalm 82 mentions “gods?”   10:28 - Are these gods extensions of rulers?   12:13 - Sponsor - Dwell - Listen to scripture throughout your day. Go to https://www.dwellbible.com/CK for 25% off!   13:25 - Sponsor - No Small Endeavor - Award-winning podcast where theologians, philosophers, and best-selling authors talk about faith with Lee C. Camp. Start listening today: https://pod.link/1513178238   14:28 - Book of Job   22:50 - Why Isn't This All Clearer?   27:01 - Evil's Real, but God's Stronger   31:45 - End Credits

On this week's episode: The White House finds the connections between JC and CK ... Rumor has it that Ryan Walters fucked a pile of flour during a board of education zoom call? ... And Don Ford will be here to read Paul's homophobic letter to the Romans. --- To make a per episode donation at Patreon.com, click here: http://www.patreon.com/ScathingAtheist To buy our book, click here: https://www.amazon.com/Outbreak-Crisis-Religion-Ruined-Pandemic/dp/B08L2HSVS8/ If you see a news story you think we might be interested in, you can send it here: scathingnews@gmail.com To check out our sister show, The Skepticrat, click here: https://audioboom.com/channel/the-skepticrat To check out our sister show's hot friend, God Awful Movies, click here: https://audioboom.com/channel/god-awful-movies To check out our half-sister show, Citation Needed, click here: http://citationpod.com/ To check out our sister show's sister show, D and D minus, click here: https://danddminus.libsyn.com/ Report instances of harassment or abuse connected to this show to the Creator Accountability Network here: https://creatoraccountabilitynetwork.org/ --- Headlines: At Kirk Service, an Extraordinary Fusion of Government and Christianity: https://www.nytimes.com/2025/09/21/us/politics/kirk-memorial-service-christianity-religion.html https://www.nytimes.com/interactive/2025/09/21/us/politics/kirk-memorial-photos.html White House's Karoline Leavitt appears to connect earthquake to Charlie Kirk's death and Biblical prophecy: https://www.independent.co.uk/news/world/americas/us-politics/charlie-kirk-death-karoline-leavitt-prophecy-earthquake-b2828284.html Trump links autism to Tylenol use during pregnancy: https://www.cnn.com/2025/09/22/health/trump-autism-announcement-cause-tylenol https://www.nytimes.com/2025/09/23/us/trump-tylenol-autism-vaccines-fact-check.html https://www.npr.org/sections/shots-health-news/2025/09/22/nx-s1-5550153/trump-rfk-autism-tylenol-leucovorin-pregnancy Pope nixes 'virtual pope' idea, explains concerns about AI: https://www.ncronline.org/vatican/vatican-news/pope-nixes-virtual-pope-idea-explains-concerns-about-ai The rapture was supposed to happen:  https://www.nytimes.com/2025/09/23/us/rapture-tiktok-sept-23.html https://substack.com/home/post/p-174218365 Oklahoma's Supreme Court blocks Ryan Walters' Bible-heavy Social Studies standards: https://www.friendlyatheist.com/p/oklahomas-supreme-court-blocks-ryan