Podcasts about ny december

Play Episode Listen Later Dec 30, 2024 3:54

BUFFALO, NY - December 30, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on December 24, 2024, titled “Pitfalls and perils from FDA-approved germ-line cancer predisposition tests." Authored by Dr. Wafik S. El-Deiry, Editor-in-Chief of Oncotarget, and Dr. Eli Y. Adashi from Brown University, the article highlights concerns about the risks of a newly approved genetic test for cancer risk. This test, called the “Invitae Common Hereditary Cancers Panel," was approved in 2023 and examines 48 genes linked to inherited cancers, including breast, ovarian, and Lynch syndrome-related cancers. Although the test increases access to genetic information, the authors warn that using it without professional guidance may lead to confusion, stress, and potential harm. One concern is that people can order this test online without consulting healthcare professionals or genetic counselors. Without expert help, users might struggle to understand their results especially if they indicate risks that are unclear or difficult to act on. This can cause unnecessary anxiety and confusion. “The DTC option of germ-line testing for cancer susceptibility should be discouraged given the risks of anxiety, lack of adequate interpretation for variants not strongly associated with cancer, potential for minors to be tested outside the healthcare system and potential for loss of follow-up if test results are not shared with health care professionals or never make it into the medical record.” The editorial also points out ethical and medical issues when minors use these tests. If a child's test is done without medical oversight, results might not be added to their health records, making follow-up care harder to manage and potentially risking their long-term health. Cost is another issue. These tests are often not covered by insurance, which can place a financial burden on families who might need additional testing or medical advice. The researchers emphasize that genetic testing for cancer risk should always include healthcare providers and genetic counseling. This ensures users fully understand their results and receive proper guidance. The authors also call on the US Food and Drug Administration (FDA) to provide clear rules for using these tests, particularly for minors. In conclusion, while genetic testing holds great potential for improving cancer prevention and care, its benefits must not come at the cost of safety and public health. Responsible use of these tests will require collaboration between regulators, healthcare professionals, and testing companies to address the risks and ensure these tools are used effectively. DOI - https://doi.org/10.18632/oncotarget.28677 Correspondence to - Wafik S. El-Deiry - wafik@brown.edu Video short - https://www.youtube.com/watch?v=DjKpiBNDWHo Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

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Dr. Marco Demaria Named Editor-In-Chief of Aging (Aging-US)

Play Episode Listen Later Dec 19, 2024 3:14

BUFFALO, NY- December 19, 2024 – We are pleased to announce that Dr. Marco Demaria, a leading expert in aging and cellular senescence, will join Aging (Aging-US) as Editor-in-Chief, starting January 1, 2025. Dr. Demaria will work alongside an esteemed Editorial Board. Dr. Demaria has an impressive background in aging research. He earned his PhD in Molecular Medicine from the University of Torino, Italy. In 2010, he joined the laboratory of Aging Founding Editor, the late Dr. Judith Campisi, at the Buck Institute for Research on Aging. There he developed cellular and animal models for studying cellular aging, also known as cellular senescence, and its role in tissue repair, cancer, and aging. Currently, Dr. Demaria leads DemariaLab, whose mission is “to extend human healthspan by pioneering discoveries in molecular and cellular mechanisms that regulate the aging process.” His groundbreaking research has significantly advanced our understanding of cellular senescence and its role in aging and age-related diseases. Dr. Demaria aims to develop new therapeutic approaches to create more effective treatments that mitigate the diseases and extend the healthspan. His work specifically focuses on interfering with the mechanisms of cellular senescence using genetic, pharmacological, and nutraceutical strategies. “My research is focused on understanding the molecular basis of age-related dysfunctions and disorders, and to identify new molecular and cellular targets to improve health and longevity.” - Marco Demaria He is also a Full Professor at the European Research Institute for the Biology of Ageing (ERIBA), Director of the Mechanisms of Health, Ageing and Disease (MoHAD) at the University Medical Center Groningen (UMCG), President of the International Cell Senescence Association (ICSA), and Co-Founder of Cleara Biotech. Dr. Demaria also brings valuable editorial experience from his former positions as Editor-in-Chief of npj Aging and Editorial Board member of Aging Cell. All the above, combined with Dr. Demaria's academic contributions, commitment, and expertise, align perfectly with Aging's mission to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. For more information about Marco Demaria, PhD, please visit www.demarialab.com and follow him on X (Twitter) @marc_dema or on Bluesky @marcdema.bsky.social. About Aging-US Please visit our website at https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Mesenchymal Cell Vesicles Target Chondrocyte Aging in Osteoarthritis

Play Episode Listen Later Dec 18, 2024 4:52

BUFFALO, NY- December 18, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 22, 2024, entitled, “Anti-aging effect of extracellular vesicles from mesenchymal stromal cells on senescence-induced chondrocytes in osteoarthritis.” The study, authored by Jérémy Boulestreau, Marie Maumus, Giuliana Bertolino Minani, Christian Jorgensen, and Danièle Noël from the Institute for Regenerative Medicine and Biotherapy and Centre Hospitalier Universitaire de Montpellier, introduces a potential new therapy for osteoarthritis. This therapy uses tiny particles called extracellular vesicles (EVs), derived from fat tissue, to repair damage caused by aging cells in the joints, slowing the progression of osteoarthritis and restoring joint health. Osteoarthritis, the most common joint disorder in older adults, occurs when cartilage breaks down, leading to inflammation, stiffness, and pain. One major contributor to it is cellular senescence, a process where cells stop dividing and release harmful substances that worsen inflammation and damage joint tissues. In this study, the researchers showed that EVs from fat-derived mesenchymal stromal cells (ASC-EVs) decreased the harmful effects of senescent cells. ASC-EVs showed strong therapeutic effects in both cellular and mouse preclinical studies. They reduced inflammation and DNA damage markers in cells derived from human joints and improved cellular health. In mice with osteoarthritis, the vesicles restored joint balance, reduced cartilage damage, and preserved joint function for weeks. The findings highlight the potential of regenerative medicine, which uses the body's own mechanisms to repair damage. By targeting the aging process in joint cells, this therapy offers a breakthrough for osteoarthritis treatment. Millions of people suffering from joint pain, inflammation, and reduced mobility could benefit from this innovative approach. In the future, the researchers plan to explore ways to enhance the therapy, including whether repeated treatments could provide even longer-lasting benefits. These could lead to new options in treating osteoarthritis and other age-related conditions. “In addition to their anti-inflammatory and regenerative properties, our study confirms that ASC-EVs may be a relevant option for future clinical applications in degenerative diseases, such as OA, which are increasing with the population aging.” In conclusion, this research offers a promising regenerative therapy for osteoarthritis, with the potential to improve the quality of life for millions of older adults. DOI - https://doi.org/10.18632/aging.206158 Corresponding author - Danièle Noël - daniele.noel@inserm.fr Video short - https://www.youtube.com/watch?v=06qw2nR3ovY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206158 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

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Sexual Dimorphism in Thermotherapy Responses in APP/PS1 Mice

Play Episode Listen Later Dec 17, 2024 4:40

BUFFALO, NY- December 17, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 29, 2024, entitled, “Thermotherapy has sexually dimorphic responses in APP/PS1 mice.” Researchers Samuel A. McFadden, Mackenzie R. Peck, Lindsey N. Sime, MaKayla F. Cox, Erol D. Ikiz, Caleigh A. Findley, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R. Hascup, and Kevin N. Hascup from Southern Illinois University School of Medicine, found that raising body temperature through heat therapy improved memory in male mice with Alzheimer's disease but worsened memory in females. These findings emphasize the importance of personalized treatments based on sex-specific responses to therapy. Alzheimer's disease (AD) is a progressive brain disorder characterized by memory loss and confusion. It is caused by the buildup of harmful proteins like beta-amyloid, which damages brain cells over time. In this study, genetically modified mice predisposed to develop Alzheimer disease (APP/PS1 mice) were kept in warmer environments for six months to explore the effects of heat therapy on memory and metabolism. The results revealed that male mice benefited from the therapy, with improved memory and reduced levels of beta-amyloid in their brains. Female mice, however, experienced a worsening of memory, likely due to increased inflammation triggered by the heat therapy. Inflammation, where the immune system is hyperactivated, can harm brain cells and worsen Alzheimer's disease symptoms. “Thermotherapy improved spatial navigation in male C57BL/6 and APP/PS1 mice, with the later attributed to reduced hippocampal soluble amyloid-β (Aβ)42. Female APP/PS1 mice exhibited worse spatial memory recall after chronic thermotherapy.” Heat therapy is already known to provide general health benefits, such as improving heart health and regulating blood sugar. This study suggests it could also offer a simple, non-drug approach to slowing Alzheimer's progression, particularly for men. Unlike exercise, which offers similar benefits, heat therapy is accessible for people who are weak or unable to engage in physical activity. While these findings are promising, the researchers emphasize the need for more studies to understand why men and women respond so differently to heat therapy. Future research should also investigate whether the results can be replicated in humans and how the therapy can be tailored to individual needs. In conclusion, heat therapy could present a safe and practical option for managing Alzheimer's disease, particularly in men. However, the observed gender differences highlight the importance of further research to refine its therapeutic potential and ensure it benefits everyone. DOI - https://doi.org/10.18632/aging.206156 Corresponding author - Kevin N. Hascup - khascup49@siumed.edu Video short - https://www.youtube.com/watch?v=IeMPHss4vj8 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

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Ep. 272: Nickel Boys, Young Werther, The Man in the White Van, Endless Summer Syndrome

CinemAddicts

Play Episode Listen Later Dec 12, 2024 76:01

On CinemAddicts Episode 271, we review movies that are coming out December 13, 2024. New films covered include "The Man in the White Van," "Young Werther," "Nickel Boys," and "Endless Summer Syndrome." Cinema-Attic inhabitant Bruce Purkey also delivers a couple of recommends with "Beetlejuice Beetlejuice," "Smile 2," and "Adult Swim Yule Log 2: Branching Out." (0:00) - Intro (15:45) - The Man in the White Van arrives in theaters December 13. Photo/poster: Relativity Media. (22:18) - Young Werther hits Theaters, Digital, and On Demand 12/13. Photo/poster: Lionsgate. (32:12) - Nickel Boys hits NY December 13 and Los Angeles December 20th. More cities in subsequent weeks. Photos/poster courtesy of Orion Pictures (42:44) - Bruce Purkey is stuck in the Cinem-Attic!! (44:12) - Endless Summer Syndrome - in theaters and VOD 12/13. Photo/poster: Altered Innocence. (53:28) - The Man in the White Van (61:54) - Smile 2 (68:03) - Beetlejuice Beetlejuice (72:12) - Adult Swim Yule Log 2: Branching Out ***Support CinemAddicts by purchasing/renting movies using our Amazon affiliate links or our SiteStripe. ***CinemAddicts Movie Picks (worth Renting/Purchasing) include: Seven Cemeteries Dominique The Unlikely Pilgrimage of Harold Fry Red Rooms Take Cover For Ad-Free CinemAddicts episodes, subscribe to our CinemAddicts YouTube Channel. Like Our CinemAddicts Facebook Page Join our CinemAddicts Facebook Group for daily movie recommendations. Questions/comments on CinemAddicts email Greg Srisavasdi at info@findyourfilms.com. Our website is Find Your Film. Shop our CinemAddicts Merch store (shirts, hoodies, mugs). Interested in what book Eric Holmes is adapting into a screenplay? Check out Patera. CinemAddicts hosts: Bruce Purkey, Eric Holmes, Greg Srisavasdi Thanks to our Patreon Community 1. Ryan Smith 2. Stephen Schrock 3. Susan 4. Charles Peterson 5. Nelson B. McClintock 6. Diana Van De Kamp 7. Pete Abeyta 8. Tyler Andula 9. Stephen Mand 10. Edmund Mendez 11. Abbie Schmidt 12. Jeff Tait 13. Superfan Giovanni 14. Robert Prakash 15. Kristen 16. Chris M 17. Jeremy Chappell 18. Lewis Longshadow 19. Iver 20. Alex Clayton 21. Daniel Hulbert 22. Andrew Martin 23. Angela Clark 24. Myron Freeman 25. Kayn Kalmbach 26. Aaron Fordham 27. Tracy Peters 28. Grant Boston 29. Ken Cunningham

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Breakthroughs in Cell-Penetrating Monoclonal Antibody Therapies

Play Episode Listen Later Dec 11, 2024 3:26

BUFFALO, NY - December 11, 2024 – A #news feature on the #research paper “Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition” by Rackear et al. was #published in Oncotarget's Volume 15 on November 22, 2024, titled “Advancements in cell-penetrating monoclonal antibody treatment." This new publication by Sai Pallavi Pradeep and Raman Bahal from the Department of Pharmaceutical Sciences at the University of Connecticut highlights significant advancements in monoclonal antibody (mAb) therapies. The focus is on the 3E10 antibody, originally derived from autoimmune mouse studies in systemic lupus erythematosus. Unlike traditional mAbs, which struggle to reach intracellular targets, this cell-penetrating antibody targets cancer cells by addressing a major limitation of current therapies. By targeting RAD51, a key intracellular protein involved in DNA repair, the 3E10 antibody shows great promise for cancer treatment, particularly in cancers with defective DNA repair pathways. mAbs have already changed the landscape of cancer therapy, offering treatments that are more targeted and have fewer side effects compared to chemotherapy. However, current therapies are limited since mAbs only target proteins on the surface of cancer cells. This research pushes the boundaries by demonstrating how 3E10 antibodies can penetrate cells and access their internal molecules. This unique capability expands the potential of mAb therapies and targeted cancer treatments. Different humanized versions of the 3E10 antibody were created and carefully tested. Some versions were particularly effective at blocking RAD51, while others showed promise for carrying other therapeutic molecules like genetic material into the cancer cells. This flexibility means that 3E10 could be used to treat different cancer types and deliver various therapeutic molecules directly into tumor cells. This progress offers exciting new possibilities for treating cancer tumors that are resistant to conventional therapies. In conclusion, the 3E10 antibody's dual function—targeting DNA repair pathways and delivering therapeutic molecules—positions it as a transformative tool in cancer research and targeted cancer treatments. DOI - https://doi.org/10.18632/oncotarget.28674 Correspondence to - Raman Bahal - raman.bahal@uconn.edu Video short - https://www.youtube.com/watch?v=3uMdPvThFHA Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28674 Subscribe for free publication alerts from Oncotarget: https://www.oncotarget.com/subscribe/ Keywords - cancer, monoclonal anti-bodies, cell penetration, nucleic acid delivery, 3E10 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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Accelerated Aging in Young Sickle Cell Patients Linked to Elevated T-cell p16INK4a

Play Episode Listen Later Dec 11, 2024 5:40

BUFFALO, NY- December 11, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 14, 2024, entitled, “Adolescents and young adults with sickle cell disease exhibit accelerated aging with elevated T-cell p16INK4a expression.” Researchers Samuel R. Wilson, Natalia Mitin, Vanessa L. Ayer Miller, Andrew B. Smitherman, and Marcus A. Carden, from the University of North Carolina at Chapel Hill, Sapere Bio, Campbell University, and Cogent Biosciences have discovered that young people with sickle cell disease (SCD) exhibit signs of accelerated biological aging compared to those without the disease. By measuring levels of p16INK4a, a key marker of cellular aging, the team found significantly higher levels in individuals with SCD. Remarkably, some participants showed biological aging equivalent to an additional 43 years. These findings suggest that SCD may drive faster aging in the body, offering new insights into the disease's long-term impact. Sickle cell disease (SCD) is a genetic condition primarily affecting individuals of African or Mediterranean descent. While treatments have advanced, people with SCD often face significant health challenges, including complications that mimic the effects of aging. Cellular aging, or senescence, occurs when cells stop dividing yet continue to send harmful signals that damage surrounding tissues. Researchers believe this process happens at an accelerated rate in people with SCD, underscoring the importance of finding ways to slow it down and mitigate its impact. The study compared p16INK4a levels in 18 adolescents and young adults with SCD to 27 healthy people of the same age. The results showed that even the youngest participant with SCD had higher levels of this aging marker than anyone in the non-SCD group. “Our youngest participant, a 15-year-old with SCD, had a higher p16 expression than all the comparators, underscoring the early rise of p16 expression in this population.” The researchers believe this faster aging could be caused by the chronic inflammation, lack of oxygen, and stress on the body associated with SCD. Along with managing the symptoms of the disease, SCD patients also face a higher risk of aging-related problems like organ damage and physical decline much earlier in life. The findings suggest that measuring p16INK4a levels could help clinicians identify patients at risk for these problems earlier and offer targeted care. The study also opens the door to new treatments, such as drugs that aim to remove old, damaged cells. These therapies could potentially slow down the aging process. Further research is essential to confirm these findings and to gain a deeper understanding of how to support SCD patients effectively. Larger, long-term studies could investigate whether therapies targeting cell aging can help prevent complications and improve the quality of life for individuals with SCD. In conclusion, this study marks an important step in understanding how SCD accelerates aging and offers new ways to improve the lives of those living with the condition. DOI - https://doi.org/10.18632/aging.206152 Corresponding author - Samuel R. Wilson - samuel.wilson@med.unc.edu Video short - https://www.youtube.com/watch?v=QXVdxBikaqg About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com. MEDIA@IMPACTJOURNALS.COM

Prostaglandin E2's Role in Senescence and Neoplastic Escape in Human Keratinocytes

Play Episode Listen Later Dec 10, 2024 4:47

BUFFALO, NY- December 10, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 18, 2024, entitled, “Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes.” Researchers Elise Srour, Nathalie Martin, Claire Drullion, Clémentine De Schutter, Joëlle Giroud, Adrien Pioger, Julie Deslé, Laure Saas, Joe Nassour, Julien Théry, Gauthier Decanter, Nicolas Penel, Chantal Vercamer, Clara Salazar-Cardozo, Corinne Abbadie, and Olivier Pluquet from CNRS, University of Lille, the Oscar Lambret Center, and the University of Colorado School of Medicine have revealed how a molecule called Prostaglandin E2 (PGE2) influences skin aging and cancer risk. Their study shows that PGE2 not only drives skin cells to age but also enables some of these aging cells to bypass natural limits and develop into pre-cancerous cells. This process provides insights into why older skin is more susceptible to cancer. The study focused on keratinocytes, the primary cells in the outer layer of the skin. As these cells age, they enter a state called senescence, where they stop dividing to prevent damaged cells from turning cancerous. While this process typically serves as a protective mechanism, the researchers found that, in certain cases, some senescent cells can escape this state, re-enter the cell cycle, and acquire characteristics of early cancer. By examining keratinocytes from donors of different ethnicities and ages, the researchers identified the PTGS2/PGE2/EP4 pathway as a key driver of this escape process. The researchers show that blocking PGE2 or its associated pathway reduced the chances of aged cells becoming precancerous. This suggests that drugs targeting this pathway, including some anti-inflammatory medications already in use, might be repurposed to slow skin aging and prevent early-stage skin cancers. Additionally, the study also found that PGE2 levels increase in the skin as it ages, further supporting its role in skin health and disease. "These results indicate that the PTGS2/PGE2/EP4 pathway is required to induce and maintain the senescent phenotype of NHEKs, and that PGE2 level is a potential determinant of the initial steps of the age-related oncogenic process." The team also highlighted the broader implications of their work. The PTGS2/PGE2/EP4 pathway is not only linked to skin health but also to age-related inflammation, a condition that contributes to several diseases. By addressing this pathway, researchers hope to address not only skin aging but other health challenges linked to aging and chronic inflammation. In conclusion, this study reveals important molecular drivers of skin aging and early cancer, leading the way for new approaches that can promote healthier skin. DOI - https://doi.org/10.18632/aging.206149 Corresponding author - Olivier Pluquet - olivier.pluquet@ibl.cnrs.fr Video short - https://www.youtube.com/watch?v=4aNf3X2RJSw About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

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CT Radiomics and Body Composition for Predicting Hepatic Decompensation

Play Episode Listen Later Dec 9, 2024 3:43

BUFFALO, NY - December 9, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on November 22, 2024, entitled “Computed tomography-based radiomics and body composition model for predicting hepatic decompensation." Mayo Clinic researchers Yashbir Singh, John E. Eaton, Sudhakar K. Venkatesh, and Bradley J. Erickson have developed an innovative AI tool to predict hepatic decompensation in individuals with primary sclerosing cholangitis (PSC). PSC is a chronic disease that damages the bile ducts and can lead to liver failure. Hepatic decompensation marks a critical stage of advanced liver disease, and clinicians have long faced challenges in predicting who is at risk. The Mayo Clinic's new AI tool addresses this gap by combining body fat and muscle composition data with insights extracted from computed tomography (CT) scans using computational radiomics. By analyzing these tissues, the AI model identifies patterns linked to an increased risk of liver failure. The study involved 80 PSC patients, including 30 with hepatic decompensation, 30 without, and 20 patients in an external validation set. The AI model achieved impressive results, correctly identifying at-risk patients with 97% accuracy. By recognizing these risks early, clinicians may be able to intervene sooner and improve patient outcomes. While the study focused on PSC, the team emphasized the broader implications of their work. “It may hold promise for the detection of other PSC-related complications, such as cholangiocarcinoma, as well as applications in more prevalent chronic liver diseases like non-alcoholic fatty liver disease (NAFLD).” This non-invasive, data-driven approach offers a powerful way to assess health risks and provide more tailored treatments. Despite the promising findings, the researchers acknowledge the limitations of the study, which include a limited sample size and a single-center design. “However, further research is necessary to validate our findings on a large-scale, independent dataset, ensuring the robustness and generalizability of the model.” In conclusion, this study shows how detailed information from CT scans can help clinicians predict severe liver problems in patients with PSC. By identifying hidden patterns in the images, they can better understand risks and create personalized treatment plans. This approach could improve care for PSC and other long-term liver diseases. DOI - https://doi.org/10.18632/oncotarget.28673 Correspondence to - Bradley J. Erickson - bje@mayo.edu Video short - https://www.youtube.com/watch?v=QCekNtYni4w Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28673 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, radiomics, body composition, machine learning, primary sclerosing cholangitis, computer tomography About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

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B7-H4 as a Therapeutic Target in Adenoid Cystic Carcinoma

Play Episode Listen Later Dec 4, 2024 3:41

BUFFALO, NY - December 4, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on November 22, 2024, entitled “B7-H4: A potential therapeutic target in adenoid cystic carcinoma." Researchers Luana Guimaraes de Sousa and Renata Ferrarotto from The University of Texas MD Anderson Cancer Center made an important discovery about adenoid cystic carcinoma (ACC), a rare and aggressive cancer of the secretory glands. The study found that B7-H4, an inhibitory immune checkpoint, helps ACC tumors avoid attacks from the immune system. This discovery could lead to new treatments for ACC, which currently has very limited options for patients, especially when the cancer spreads to other organs. ACC is known for behaving in two distinct ways. The aggressive form, called ACC-I, spreads quickly to organs like the liver and lungs and leads to a short survival time of approximately three years. The less aggressive form, ACC-II, grows more slowly and often allows patients to live much longer, sometimes over 20 years. However, treatment options for both forms are limited, and once the cancer spreads, it becomes difficult to treat. The study showed that the protein B7-H4 is found at high levels in the aggressive ACC-I tumors. This protein blocks immune cells from entering the tumor, allowing the cancer to grow without being attacked by the immune system. Patients with high levels of B7-H4 in their tumors were found to have worse survival outcomes. To explore possible treatments, the researchers tested a new drug called AZD8205, designed to specifically target and block B7-H4. In preclinical tests on mice, the drug showed remarkable success. Tumors derived from patients shrank in every case, and in many cases of aggressive ACC, the tumors disappeared completely. Importantly, the drug had little effect on less aggressive ACC-II tumors, which have lower levels of B7-H4. This shows that the treatment is highly specific to tumors with high B7-H4 levels. These results have already led to clinical trials that are testing similar drugs in patients with ACC. “These trials represent attractive, rationale therapeutic opportunities for patients facing this rare, aggressive, and chemo-refractory disease, for which no systemic therapy is currently available.” In conclusion, this discovery represents a significant breakthrough in ACC research, identifying B7-H4 as a crucial factor in cancer growth and immune evasion. By leading the way for personalized treatments, it offers promising new therapeutic options and the potential for improved outcomes for ACC patients. DOI - https://doi.org/10.18632/oncotarget.28661 Correspondence to - Renata Ferrarotto - rferrarotto@mdanderson.org Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28661 Subscribe for free publication alerts from Oncotarget: https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

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Effects of Megakaryocyte Conditioned Media on Endothelial Cell Angiogenesis

Play Episode Listen Later Dec 4, 2024 4:22

BUFFALO, NY- December 4, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 22, 2024, entitled, “The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells.” Researchers Murad K. Nazzal, Hanisha L. Battina, Nikhil P. Tewari, Sarah L. Mostardo, Rohit U. Nagaraj, Donghui Zhou, Olatundun D. Awosanya, Saveda K. Majety, Sue Samson, Rachel J. Blosser, Ushashi C. Dadwal, Patrick L. Mulcrone, and Melissa A. Kacenaat from Indiana University School of Medicine and Richard L. Roudebush Veterans' Administration Medical Center, have uncovered how certain bone marrow cells, called megakaryocytes (MKs), promote the growth of new blood vessels (angiogenesis) to aid in bone healing. Their findings help explain why healing slows with age and offer insights into potential treatments to accelerate fracture recovery in older adults. Broken bones are common in older adults, and slower healing can lead to complications and longer hospital stays. Accelerating the healing process could significantly improve the quality of life for millions. In this study, researchers investigated the effects of substances secreted by MKs, collected from young and older male and female mice. These substances, known as conditioned media (CM), were tested for their ability to stimulate the growth and function of endothelial cells (EC), which form the building blocks of blood vessels. Blood vessels play a critical role in healing by delivering oxygen and nutrients to damaged areas, making angiogenesis a vital part of the recovery process. The results showed that CM from younger MKs mice was more effective at helping blood vessels grow. Interestingly, MKs from female mice performed better than those from males, regardless of age. For example, substances from female MKs mice boosted blood vessel growth by over 115% and significantly improved the movement of cells needed for healing. The researchers also studied changes in genes related to blood vessel growth, and found that aging affects how these genes work. These changes may explain why older people heal more slowly after breaking a bone. “An understanding of which factors regulate which mechanisms of EC functionality may allow for isolation of one or a few factors that influence EC migration changes with aging, resulting in the development of targeted therapy to improve EC migration, subsequent angiogenesis, and fracture healing.” In conclusion, this research paves the way for developing new therapies to help older individuals recover from fractures more quickly, reducing pain and improving mobility. One potential approach could involve creating treatments that replicate the effects of MKs from younger individuals or isolating the specific substances that promote blood vessel growth. This represents an important step toward addressing the growing challenge of delayed healing in an aging population. DOI - https://doi.org/10.18632/aging.206077 Corresponding authors - Patrick L. Mulcrone - pamulcro@iu.edu, and Melissa A. Kacena - mkacena@iupui.edu About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com. MEDIA@IMPACTJOURNALS.COM

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Mesenchymal Stem Cells in Cancer Immunotherapy: Promises and Challenges

Play Episode Listen Later Dec 3, 2024 3:49

BUFFALO, NY - December 3, 2024 – A new #review was #published in Oncotarget's Volume 15 on November 22, 2024, entitled “Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists." Authored by Theia Minev, Shani Balbuena, Jaya Mini Gill, Francesco M. Marincola, Santosh Kesari, and Feng Lin from CureScience Institute, Sonata Therapeutics, and Pacific Neuroscience Institute and Providence Saint John's Health Center, this review explores the potential role of mesenchymal stem cells (MSCs) in cancer treatment. These stem cells can naturally target tumors and deliver therapeutic agents directly to cancer cells, potentially improving treatment outcomes while reducing side effects commonly associated with traditional therapies like chemotherapy. However, the authors also note significant challenges, pointing out that under certain conditions, MSCs may unintentionally promote tumor growth, highlighting the need for careful therapeutic design. MSCs are cells that can develop in different types of tissues, such as bone, fat, or cartilage, and act as natural repair agents. What makes them particularly special is their ability to respond to biological signals, like inflammation, which is often present in cancer. This enables them to locate tumors, and once there, they can deliver cancer treatments directly to the affected area. Clinical trials are already investigating MSC-based treatments for cancers such as brain tumors, melanoma, and ovarian cancer. Some results are promising, showing that MSCs can effectively deliver treatments and boost the immune system's fight against cancer. However, other trials have also revealed the complexities of MSC behavior, including variability in their effects and the potential to create conditions that support tumor growth. “This variability may be due to the tumor immune microenvironment's effects, where immune cells are inhibited by various factors, creating a conducive environment for tumor growth.” The authors also suggest that “Developing personalized MSC therapies tailored to the specific characteristics of a patient's tumor and immune system could enhance the efficacy and safety of MSC-based treatments.” Achieving this requires a deeper understanding of how MSCs interact with cancer cells and their surrounding environment. In conclusion, this review highlights both the potential and challenges of (MSCs in cancer therapy. With ongoing research and technological advancements, MSCs could become a key component of personalized cancer treatments, offering new hope for patients worldwide. DOI - https://doi.org/10.18632/oncotarget.28672 Correspondence to - Feng Lin - flin@curescience.org Video short - https://www.youtube.com/watch?v=Wwc3zDDitlc Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

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Sleep Deprivation in Dementia: Heart Disease, Diabetes, Anxiety, and Thyroid Disorders

Play Episode Listen Later Dec 2, 2024 5:00

BUFFALO, NY- December 2, 2024 – A new #review was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21, titled, “Sleep deprivation in dementia comorbidities: focus on cardiovascular disease, diabetes, anxiety/depression and thyroid disorders.” The review, authored by Upasana Mukherjee, Ujala Sehar, Malcolm Brownell, and P. Hemachandra Reddy from Texas Tech University Health Sciences Center, compiles findings from recent studies on how sleep problems—such as insomnia, sleep apnea, and disrupted sleep cycles—can worsen dementia and accelerate cognitive decline. It also emphasizes the profound impact of these sleep disorders on caregivers, who often face burnout and emotional stress. Dementia is a condition that significantly impairs the ability to think, remember, and make decisions, making everyday life increasingly difficult to manage. Sleep problems are a major challenge for individuals with dementia, with more than half experiencing disturbed sleep. These disturbances include difficulty falling asleep, staying asleep, or engaging in nighttime wandering. Such issues go beyond causing fatigue—they accelerate memory loss, increase confusion, and raise the risk of behavioral symptoms like agitation. Addressing sleep challenges is critical to improving quality of life for both patients and their caregivers. Caregivers, who often support loved ones around the clock, face significant stress when dealing with these sleep disorders. “This situation creates a vicious cycle where caregiver distress exacerbates patient symptoms, further increasing the burden on caregivers.” This review also explores how other illnesses, common in older adults with dementia, worsen sleep disturbances. Conditions such as diabetes, thyroid dysfunction, heart disease, and anxiety disrupt sleep, and poor sleep then worsens both the dementia and the underlying illnesses. For instance, untreated sleep apnea can significantly accelerate cognitive decline in people with dementia. To improve sleep for dementia patients, the authors recommend holistic approaches that address both sleep disturbances and related health conditions. Simple changes, such as establishing a regular bedtime routine, reducing nighttime noise, and encouraging daytime physical activity, can significantly enhance sleep quality. Non-pharmacological treatments, including light therapy and cognitive behavioral therapy for insomnia, have also shown promise. Managing coexisting conditions such as diabetes or anxiety can help reduce the severity of sleep issues. The authors emphasize the need for more research into targeted, multidisciplinary approaches to effectively manage sleep disturbances, improve patient well-being, and reduce caregiver stress. In conclusion, this review highlights the critical need for a more comprehensive approach to dementia care. Improving sleep could slow the progression of dementia, reduce caregiver stress, and enhance the quality of life for everyone involved. As dementia cases rise worldwide, addressing sleep issues will become an increasingly important aspect of care. DOI - https://doi.org/10.18632/aging.206157 Corresponding author - P. Hemachandra Reddy - hemachandra.reddy@ttuhsc.edu Video short - https://www.youtube.com/watch?v=lrrrXabMjjM Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. Please visit our website at https://www.Aging-US.com. MEDIA@IMPACTJOURNALS.COM

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L'INTÉGRALE - #LeDriveRTL2 (02/02/24)

#LeDriveRTL2

Play Episode Listen Later Feb 2, 2024 130:19

Les nouveautés du jour : - James Vincent McMorrow "Stay Cool" - Sofia Carson "I Hope You Know" Le journal de la musique : - Pearl Jam vient de dévoiler son nouvel album - Les chats n'aiment pas qu'Ed Sheeran chante à côté d'eux L'album de votre week-end : The Specials "The Specials" Les classiques du jour : - The Human League "Don't You Want Me" - Paramore "Still Into You" Le live du jour : Bruce Springsteen & The E Street Band "Hungry Heart (Live at Nassau Coliseum, Uniondale, NY - December 1980)" ("Bruce Springsteen & The E Street Band Live 1975-85") A suivre : NewDad "Sickly Sweet"

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GFH009: A Potent and Highly Selective CDK9 Inhibitor for the Treatment of Hematologic Malignancies

Play Episode Listen Later Dec 27, 2023 3:32

BUFFALO, NY- December 27, 2023 – A new #research paper was #published in Oncotarget's Volume 14 on December 20, 2023, entitled, “The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies.” To evade cell cycle controls, malignant cells rely upon rapid expression of select proteins to mitigate pro-apoptotic signals resulting from damage caused by both cancer treatments and unchecked over-proliferation. Cyclin-dependent kinase 9 (CDK9)-dependent signaling induces transcription of downstream oncogenes promoting tumor growth, especially in hyperproliferative ‘oncogene-addicted' cancers, such as human hematological malignancies (HHMs). In this new study, researchers Fusheng Zhou, Lili Tang, Siyuan Le, Mei Ge, Dragan Cicic, Fubo Xie, Jinmin Ren, Jiong Lan, and Qiang Lu from GenFleet Therapeutics Inc. and Sellas Life Sciences Group aimed to summarize current knowledge underlying the mechanism of action (MOA) of GFH009 and explain its robust anti-cancer activity. “Understanding GFH009's MOA allows for a more optimal clinical development path, given the potential for meaningful benefits in patients with hematological malignancies.” GFH009, a potent, highly selective CDK9 small molecule inhibitor, demonstrated antiproliferative activity in assorted HHM-derived cell lines, inducing apoptosis at IC50 values below 0.2 μM in 7/10 lines tested. GFH009 inhibited tumor growth at all doses compared to controls and induced apoptosis in a dose-dependent manner. Twice-weekly injections of GFH009 maleate at 10 mg/kg significantly prolonged the survival of MV-4-11 xenograft-bearing rodents, while their body weight remained stable. There was marked reduction of MCL-1 and c-MYC protein expression post-drug exposure both in vitro and in vivo. Through rapid ‘on-off' CDK9 inhibition, GFH009 exerts a proapoptotic effect on HHM preclinical models triggered by dynamic deprivation of crucial cell survival signals. “Our results mechanistically establish CDK9 as a targetable vulnerability in assorted HHMs and, along with the previously shown superior class kinome selectivity of GFH009 vs other CDK9 inhibitors, strongly support the rationale for currently ongoing clinical studies with this agent in acute myeloid leukemia and other HHMs.” DOI - https://doi.org/10.18632/oncotarget.28543 Correspondence to - Jiong Lan - jlan@genfleet.com Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28543 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, GFH009, CDK9, leukemia, cell cycle About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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Angelica gigas Extract Inhibits Acetylation of eNOS in Vascular Dysfunction

Play Episode Listen Later Dec 27, 2023 4:44

BUFFALO, NY- December 27, 2023 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction.” Angelica gigas NAKAI (AG) is a popular traditional medicinal herb widely used to treat dyslipidemia owing to its antioxidant activity. Vascular disease is intimately linked to obesity-induced metabolic syndrome, and AG extract (AGE) shows beneficial effects on obesity-associated vascular dysfunction. However, the effectiveness of AGE against obesity and its underlying mechanisms have not yet been extensively investigated. In this new study, researchers Geum-Hwa Lee, Hwa-Young Lee, Young-Je Lim, Ji-Hyun Kim, Su-Jin Jung, Eun-Soo Jung, Soo-Wan Chae, Juwon Lee, Junghyun Lim, Mohammad Mamun Ur Rashid, Kyung Hyun Min, and Han-Jung Chae from Jeonbuk National University and Jeonbuk National University Hospital supplemented 40 high fat diet (HFD) rats with 100–300 mg/kg/day of AGE to determine its efficacy in regulating vascular dysfunction. “[...] the primary aim of this study is to examine the inhibitory effects of AGE on dyslipidemia-associated vascular dysfunction, with a focus on its potential mechanisms of action.” The vascular relaxation responses to acetylcholine were impaired in HFD rats, while the administration of AGE restored the diminished relaxation pattern. Endothelial dysfunction, including increased plaque area, accumulated reactive oxygen species, and decreased nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) Ser1177 phosphorylation, were observed in HFD rats, whereas AGE reversed endothelial dysfunction and its associated biochemical signaling. Furthermore, AGE regulated endoplasmic reticulum (ER) stress and IRE1α sulfonation and its subsequent sirt1 RNA decay through controlling regulated IRE1α-dependent decay (RIDD) signaling, ultimately promoting NO bioavailability via the SIRT1-eNOS axis in aorta and endothelial cells. Independently, AGE enhanced AMPK phosphorylation, additionally stimulating SIRT1 and eNOS deacetylation and its associated NO bioavailability. Decursin, a prominent constituent of AGE, exhibited a similar effect in alleviating endothelial dysfunctions. These data suggest that AGE regulates dyslipidemia-associated vascular dysfunction by controlling ROS-associated ER stress responses, especially IRE1α-RIDD/sirt1 decay and the AMPK-SIRT1 axis. “Ultimately, this study presents clearly evidence that AGE is a promising natural product-based functional food/herbal medicine candidate for preventing or regulating hyperlipidemic cardiovascular complications.” DOI - https://doi.org/10.18632/aging.205343 Corresponding authors - Kyung Hyun Min - khmin1492@jbnu.ac.kr, and Han-Jung Chae - hjchae@jbnu.ac.kr About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Visit https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

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"Rockin' Yuletide Beats: The Deadhead Cannabis Show's Christmas Special"

Deadhead Cannabis Show

Play Episode Listen Later Dec 25, 2023 74:59

"Tunes of the Season: Phish, Grateful Dead, and Merry Jams"Larry Mishkin discusses Christmas-themed songs performed by various artists, including The Who and Grateful Dead. Larry delves into The Who's rock opera "Tommy," particularly focusing on the song "Christmas" and its critical reception. He transitions to discussing Grateful Dead's rendition of Chuck Berry's "Run, Rudolph, Run" performed at the Felt Forum in 1971 and analyzes its significance in the band's repertoire.Larry further explores the potential residency of bands like Dead & Company at the Sphere in Las Vegas, following U2's shows there. He touches on Phish's upcoming performances at the same venue and discusses the difficulty in acquiring tickets for these highly anticipated shows.Later, Larry reminisces about New Year's Eve shows by various bands, specifically mentioning Grateful Dead's memorable performances during the countdown. He also features unconventional Christmas renditions by Phish and Jerry Garcia with David Grisman..Produced by PodConx Theme – Rock n Roll ChristmasIf you were in the Mishkin household earlier this morning, you might have heard this blasting out of the speakers:INTRO: ChristmasThe WhoFebruary 14, 1970University of Leeds, Leeds, England aka “Live At Leeds”The Who - Christmas - Live At Leeds (with Footage) (youtube.com)2:00 – 3:17 "Christmas" is a song written by Pete Townshend and is the seventh song on The Who's rock opera Tommy. On the original LP, it opens the second side of the album. Tommy is the fourth studio album by the English rock band the Who, first released on 19 May 1969.[2] Primarily written by guitarist Pete Townshend, Tommy is a double album and an early rock opera that tells the story of Tommy Walker and his experiences through life. The song tells how on Christmas morning, Tommy's father is worried about Tommy's future, and soul. His future is jeopardized due to being deaf, dumb, and blind.[2] The lyrics contrast religious themes such as Christmas and Jesus Christ with Tommy's ignorance of such matters. The rhetorical question, "How can he be saved from the eternal grave?" is asked about Tommy's condition and adds speculation as to the nature of original sin and eternal salvation. In the middle of the song, "Tommy can you hear me?" is repeated, with Tommy responding, "See me, feel me, touch me, heal me." "Christmas" was praised by critics. Richie Unterberger of AllMusic called it an "excellent song."[5]Rolling Stone's Mac Randall said it was one of several "prime Pete Townshend songs" on the album.[6] A review in Life by Albert Goldman considered it beautiful and highlighted the song's "croaking chorus".[7] James Perone said it was "perhaps one of the best sleeper tracks of the collection." Townshend came up with the concept of Tommy after being introduced to the work of Meher Baba, and he attempted to translate Baba's teachings into music. Recording on the album began in September 1968, but took six months to complete as material needed to be arranged and re-recorded in the studio. Tommy was acclaimed upon its release by critics, who hailed it as the Who's breakthrough. Its critical standing diminished slightly in later years; nonetheless, several writers view it as an important and influential album in the history of rock music. The Who promoted the album's release with an extensive tour, including a live version of Tommy, which lasted throughout 1969 and 1970. Key gigs from the tour included appearances at Woodstock, the 1969 Isle of Wight Festival, the University of Leeds, the Metropolitan Opera House, and the 1970 Isle of Wight Festival. The live performances of Tommy drew critical praise and revitalised the band's career. Live at Leeds is the first live album by English rock band the Who. It was recorded at the University of Leeds Refectory on 14 February 1970, and is their only live album that was released while the group were still actively recording and performing with their best-known line-up of Roger Daltrey, Pete Townshend, John Entwistle and Keith Moon. The album was released on 11 May 1970 by Decca and MCA in the United States,[2] and by Track and Polydor in the United Kingdom. It has been reissued on several occasions and in several different formats. Since its release, Live at Leeds has been ranked by several music critics as the best live rock recording of all time SHOW No. 1: Run Rudolph RunGrateful DeadFelt Forum at MSG, NYCDecember 7, 1971Track No. 10Grateful Dead Live at Felt Forum, Madison Square Garden on 1971-12-07 : Free Borrow & Streaming : Internet Archive0:11 – 1:54 Run Rudolph Run"[2][3][4] is a Christmas song written by Chuck Berry but credited to Johnny Marks and M. Brodie due to Marks' trademark on the character of Rudolph the Red-Nosed Reindeer.[5][note 1] It was published by St. Nicholas Music (ASCAP) and was first recorded by Berry in 1958, released as a single on Chess Records.It has since been covered by numerous other artists, sometimes with the title "Run Run Rudolph".[16] The song is a 12-bar blues, musically similar to Berry's popular and recognizable song "Johnny B. Goode", and melodically similar to his song "Little Queenie", the latter of which was released shortly after, in 1959.During its initial chart run, Berry's 1958 recording peaked at number 69 on the Billboard Hot 100 chart in December 1958.[22] Sixty years later, the single re-entered the Hot 100 chart at number 45 (on the week ending January 5, 2019), reaching an overall peak position of number 10 on the week ending January 2, 2021, following its third chart re-entry, becoming Berry's third top-ten hit and his first since 1972's "My Ding-a-Ling". In doing so, it broke the record for the longest climb to the top 10 since its first entry in December 1958, at 62 years and two weeks.This Ciip:Out of Brokedown Palace and into You Win AgainPlayed a total of 7 times.This was the first timeLast: December 15, 1971 Hill Auditorium, Ann Arbor, MI SHOW No. 2: Little Drummer BoyPhishJuly 3, 1999Coca Cola Lakewood Amphitheatre, Atlanta, GAPhish - The Little Drummer Boy - 7/3/1999 - Atlanta, GA (youtube.com)Start to 1:30 Out of Contact to close the second set. Played it again as the first encore (into, Won't You Come Home Bill Bailery starring Page's dad, Jack, on vocals and kazoo. "The Little Drummer Boy" (originally known as "Carol of the Drum") is a Czechoslovakian popular Christmas song written by American composer Katherine Kennicott Davis in 1941.[1] First recorded in 1951 by the Austrian Trapp Family, the song was further popularized by a 1958 recording by the Harry Simeone Chorale; the Simeone version was re-released successfully for several years, and the song has been recorded many times since.[2] In the lyrics, the singer relates how, as a poor young boy, he was summoned by the Magi to the Nativity of Jesus. Without a gift for the Infant, the little drummer boy played his drum with approval from Jesus' mother, Mary, recalling, "I played my best for him" and "He smiled at me". Phish has only performed the song three times during the month of December – the debut performance segueing out of “Mike's Song” and into “Whipping Post,” a tease during the 12/28/94 “Weekapaug Groove,” and jammed out of the “YEM” vocal jam (12/2/99) (which melted down until Jon was left singing it to close the set). But the song was jammed out of season during “My Friend, My Friend” (3/18/93) and “Stash” (7/15/93), and teased during “Weekapaug Groove” and “Big Ball Jam” (4/9/94), “Wilson” (8/13/97), “Silent in the Morning” (7/4/99), and "Wilson" (4/16/04). This version is generally considered to be Fishman's most memorable version. SHOW No. 3: God Rest Ye Merry GentlemenJerry Garcia and David GrismanNovember 9, 1991Warfield Theater, S.F.God Rest Ye Merry Gentlemen - Jerry Garcia - Bing videoStart – 1:37Out of The Two Sisters to close second set "God Rest You Merry, Gentlemen" is an English traditional Christmas carol. It is in the Roxburghe Collection (iii. 452), and is listed as no. 394 in the Roud Folk Song Index. It is also known as "Tidings of Comfort and Joy", and by other variant incipits. An early version of this carol is found in an anonymous manuscript, dating from the 1650s it appeared in a parody published in 1820 by William Hone. Story here is the way Jerry and David play so tight, trading off leads and filling in gaps. A great sound for a traditional tune. There are many sides of Jerry and we don't get to see all of them. Nice to take a break from the traditional Dead stuff and take a look in at what else Garcia was doing during that creative period of his life. SHOW No. 4: Stagger LeeGrateful DeadDecember 30, 1985Track No. 6Grateful Dead Live at Oakland Coliseum on 1985-12-30 : Free Borrow & Streaming : Internet ArchiveStart – 1:32 As is made clear by the opening lyrics, this is a tale about events that unfolded and played out on Christmas: “1940 Xmas Eve with a full moon over town”. On some occasions, Jerry was known to substitute in “Christmas” Eve. "Stagger Lee", also known as "Stagolee" and other variants, is a popular American folk song about the murder of Billy Lyons by "Stag" Lee Shelton, in St. Louis, Missouri, at Christmas 1895. The song was first published in 1911 and first recorded in 1923, by Fred Waring's Pennsylvanians, titled "Stack O' Lee Blues". A version by Lloyd Price reached number one on the Billboard Hot 100 in 1959. The historical Stagger Lee was Lee Shelton, an African-American pimp living in St. Louis, Missouri, in the late 19th century. He was nicknamed Stag Lee or Stack Lee, with a variety of explanations being given: he was given the nickname because he "went stag" (went to social events unaccompanied by a person of the opposite sex); he took the nickname from a well-known riverboat captain called Stack Lee; or, according to John and Alan Lomax, he took the name from a riverboat owned by the Lee family of Memphis called the Stack Lee, which was known for its on-board prostitution.[2] Shelton was well known locally as one of the Macks, a group of pimps who demanded attention through their flashy clothing and appearance.[3] In addition to those activities, he was the captain of a black Four Hundred Club, a social club with a dubious reputation. On Christmas night in 1895, Shelton and his acquaintance William "Billy" Lyons were drinking in the Bill Curtis Saloon. Lyons was also a member of St. Louis' underworld, and may have been a political and business rival to Shelton. Eventually, the two men got into a dispute, during which Lyons took Shelton's Stetson hat.[5]Subsequently, Shelton shot Lyons, recovered his hat, and left.[6] Lyons died of his injuries, and Shelton was charged, tried, and convicted of the murder in 1897. He was paroled in 1909, but returned to prison in 1911 for assault and robbery. He died in incarceration in 1912. The Grateful Dead frequently played and eventually recorded a version of the tale which focuses on the fictionalized hours after the death of "Billy DeLyon", when Billy's wife Delia tracks down Stagger Lee in a local saloon and "she shot him in the balls" in revenge for Billy's death. Based on the traditional song "Stagger Lee", "Stagolee" or "Stack O'Lee." Robert Hunter wrote a version that he performed solo, and Jerry Garcia subsequently re-ordered the lyrics and rewrote the music for the Grateful Dead's version. More recently Bob Weir has also been performing some of the older traditional versions with Ratdog. Dead released it on Shakedown Street, Nov. 8, 1978 Played 146 times by the Dead1st: August 30, 1978Last: June 18, 1995 Giants Stadium OUTRO: Santa Clause Is Coming To TownBruce Springsteen and the E Street BandCW Post University, Greenvale, NYDecember, 19756Santa Claus Is Comin' to Town (Live at C.W. Post College, Greenvale, NY - December 1975) - Bing video2:15 - 4:00 Santa Claus Is Comin' to Town" is a Christmas song featuring Santa Claus, written by J. Fred Coots and Haven Gillespie and first recorded by Harry Reser and His Band.[1] When it was covered by Eddie Cantor on his radio show in November 1934 it became a hit; within 24 hours, 500,000 copies of sheet music and more than 30,000 records were sold.[2][3] The version for Bluebird Records by George Hall and His Orchestra (vocal by Sonny Schuyler) was very popular in 1934 and reached the various charts of the day.[4] The song has been recorded by over 200 artists including Bing Crosby and the Andrews Sisters, the Crystals, Neil Diamond, Fred Astaire, Bruce Springsteen, Frank Sinatra, Bill Evans, Chris Isaak, the Temptations, The Pointer Sisters, the Carpenters, Michael Bublé, Luis Miguel, and the Jackson 5 A rock version by Bruce Springsteen & the E Street Band was recorded on December 12, 1975, at C. W. Post College in Brookville, New York, by Record Plant engineers Jimmy Iovine and Thom Panunzio.[14][15] This version borrows the chorus refrain from the 1963 recording by the Crystals.[16] It was first released as a track on the 1981 Sesame Street compilation album, In Harmony 2, as well as on a 1981 promotional, radio-only, 7-inch single (Columbia AE7 1332).[17][18] Four years later, it was released as the B-side to "My Hometown," a single off the Born in the U.S.A. album.[19] Springsteen's rendition of the song has received radio airplay perennially at Christmastime for years; it appeared on Billboard magazine's Hot Singles Recurrents chart each year from 2002 to 2009 due to seasonal air play. Live performances of the song often saw the band encouraging the audience to sing some of the lyrics with—or in place of—the band's vocalists (usually the line "you'd better be good for goodness sake", and occasionally the key line "Santa Claus is Comin' to Town" as well). Sometimes, concert crowds would sing along with the entire song, and the band, who were known to encourage this behavior for the song, would do nothing to dissuade those audiences from doing so, instead welcoming the crowds' enthusiasm. This version remains a Springsteen concert favorite during the months of November and December (often concluding the show), and the band is among the few that keep it in their roster of songs during the holidays. Dead & Co at the Sphere?Phish – sold out fast Merry ChristmasHappy Holidays .Produced by PodConx Deadhead Cannabis Show - https://podconx.com/podcasts/deadhead-cannabis-showLarry Mishkin - https://podconx.com/guests/larry-mishkinRob Hunt - https://podconx.com/guests/rob-huntJay Blakesberg - https://podconx.com/guests/jay-blakesbergSound Designed by Jamie Humiston - https://www.linkedin.com/in/jamie-humiston-91718b1b3/Recorded on Squadcast

christmas united states jesus christ american new york university new year live english las vegas england song story united kingdom african americans dead track missouri run comfort christmas eve ga cannabis rolling stones recording beats silent christmas special santa claus garcia played billboard bruce springsteen leeds gentlemen lp won frank sinatra woodstock drum u2 isle magi temptations madison square garden infants sesame street bing crystals rudolph msg christmastime tunes nativity rockin ann arbor lyons grateful dead sphere footage baba sixty shelton ling subsequently chuck berry stash yuletide phish bing crosby neil diamond luis miguel carpenters billboard hot fishman red nosed reindeer fred astaire jerry garcia mca two sisters michael bubl simeone bill evans tidings deadheads e street band pete townshend squadcast pennsylvanians roger daltrey pointer sisters little drummer boy keith moon chris isaak decca all music bob weir jimmy iovine xmas eve his orchestra oakland coliseum johnny b goode polydor alan lomax andrews sisters townshend macks robert hunter john entwistle czechoslovakian chess records eddie cantor tommy walker metropolitan opera house lloyd price santa claus is comin david grisman in harmony brookville stagger lee mishkin my hometown wight festival his band record plant shakedown street meher baba dead company yem whipping post dead co greenvale run rudolph run fred waring brokedown palace ratdog george hall run run rudolph ny december little queenie richie unterberger podconx haven gillespie weekapaug groove

Management of Refractory or Relapsed Classic Hodgkin Lymphoma in Brazil

Play Episode Listen Later Dec 21, 2023 3:29

BUFFALO, NY- December 20, 2023 – A new #review paper was #published in Oncotarget's Volume 14 on December 12, 2023, entitled, “Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in Brazil: Balancing efficacy, safety, and tolerability.” Classic Hodgkin lymphoma (CHL), which accounts for 90–95% of all cases of Hodgkin lymphoma, is the most frequent cancer in adolescents and the most frequent lymphoma in adolescents and young adults. Despite progressive improvements over past decades and the general sensitivity of CHL to frontline chemotherapy, approximately 10–15% of patients have refractory disease that either does not respond to such therapy or progresses after an initial partial response. In patients with refractory or relapsed disease, standard treatment until recently consisted mainly of salvage chemotherapy, in many cases followed by high-dose chemotherapy and autologous stem-cell transplantation. However, improved understanding of the pathobiology of CHL, coupled with the introduction of novel agents, has markedly changed the treatment landscape in the past decade. Although refractory or relapsed CHL continues to be challenging, the therapeutic landscape is undergoing profound changes brought about by novel agents, particularly brentuximab vedotin and immunotherapy. In this new review, researchers Flávia Dias Xavier, Danielle Leão Cordeiro de Farias, Abrahão Elias Hallack Neto, Glaciano Nogueira Ribeiro, Marco Aurelio Salvino de Araujo, Thiago Xavier Carneiro, and Otavio Cesar Carvalho Guimarães Baiocchi from Hospital Universitário de Brasília-Universidade de Brasília/Ebserh, Hospital DF Star, Hospital A Beneficência Portuguesa de São Paulo, Universidade Federal de Juiz de Fora, Clínica Hematológica/Grupo Oncoclinicas, Universidade Federal da Bahia, Instituto D'Or de Pesquisa e Ensino, Universidade Estadual do Pará, Universidade Federal de São Paulo, and Hospital Alemão Oswaldo Cruz discuss the most salient treatment options for adult patients with refractory or relapsed CHL, with a special focus on the Brazilian healthcare setting, which is constrained by inherent characteristics of this system. “In the attempt to balance efficacy, safety and tolerability, practicing physicians must rely on clinical trials and on results from real-world studies, and use their own point of view and experience, as well as patient characteristics and previous therapy, to make treatment decisions for refractory or relapsed CHL.” DOI - https://doi.org/10.18632/oncotarget.28541 Correspondence to - Flávia Dias Xavier - flavia.xavier@unb.br Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28541 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, brentuximab vedotin, drug therapy, hodgkin lymphoma, nivolumab, pembrolizumab About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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Benidipine Calcium Channel Blocker Improves Cigarette Smoke-Induced Lung Emphysema

Play Episode Listen Later Dec 21, 2023 3:27

BUFFALO, NY- December 20, 2023 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema.” Smoking is the main risk factor for many lung diseases including chronic obstructive pulmonary disease. Cigarette smoke (CS) contains carcinogenic and reactive oxygen species that favor DNA mutations and perturb the homeostasis and environment of cells. CS induces lung cell senescence resulting in a stable proliferation arrest and a senescence-associated secretory phenotype. It was recently reported that senescent cell accumulation promotes several lung diseases. In this new study, researchers Alberta Palazzo, Gabriela Makulyte, Delphine Goerhig, Jean-Jacques Médard, Vincent Gros, François Trottein, Serge Adnot, David Vindrieux, Jean-Michel Flaman, and David Bernard from Université de Lyon, Equipe Labellisée la Ligue Contre le Cancer, Université Paris Est Créteil, Hôpital Henri Mondor, and Université Lille performed a chemical screen, using an FDA-approved drug library, to identify compounds selectively promoting the death of CS-induced senescent lung cells. “Here, our aim was to identify senolytic compounds in the context of CS-induced senescence and to assess whether they improved lung emphysema.” Aside from the well-known senolytic, ABT-263, the researchers identified other potentially new senescence-eliminating compounds, including a new class of molecules, the dihydropyridine family of calcium voltage-gated channel (CaV) blockers. Among these blockers, Benidipine decreased senescent lung cells and ameliorates lung emphysema in a mouse model. The dihydropyridine family of CaV blockers thus constitutes a new class of senolytics that could improve lung diseases. “Hence, our work paves the way for further studies on the senolytic activity of CaV blockers in different senescence contexts and age-related diseases.” DOI - https://doi.org/10.18632/aging.205259 Corresponding author - David Bernard - david.bernard@lyon.unicancer.fr Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205259 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senolytic, cigarette smoke, lung disease, cellular senescence, calcium channel About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

covid-19 dna cancer web soundcloud buffalo pinterest smoke fda universit smoking lyon cs cigarettes improves lung induced calcium doi blocker abt cav emphysema david bernard henri mondor universit paris est cr altmetric ny december universit lille

Sirtuin 6 Activation Rescues the Age-Related Decline in DNA Damage Repair in Chondrocytes

Play Episode Listen Later Dec 19, 2023 3:53

BUFFALO, NY- December 19, 2023 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes.” While advanced age is widely recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of DNA damage as compared to chondrocytes from younger donors. In this new study, researchers Michaela E. Copp, Jacqueline Shine, Hannon L. Brown, Kirti R. Nimmala, Oliver B. Hansen, Susan Chubinskaya, John A. Collins, Richard F. Loeser, and Brian O. Diekman from University of North Carolina at Chapel Hill, North Carolina State University, Rush University Medical Center, and Thomas Jefferson University aimed to determine whether a decline in DNA repair efficiency is one explanation for the accumulation of DNA damage with age, and to quantify the improvement in repair with activation of Sirtuin 6 (SIRT6). “In this study, we use irradiation as an acute model of DNA damage to bring the level of damage to equivalent levels across chondrocytes from donors of various ages.” After acute damage with irradiation, DNA repair was shown to be more efficient in chondrocytes from young (≤45 years old) as compared to middle-aged (50–65 years old) or older (>70 years old) cadaveric donors. Activation of SIRT6 with MDL-800 improved the repair efficiency, while inhibition with EX-527 reduced the rate of repair and increased the percentage of cells that retain high levels of damage. In addition to affecting repair after acute damage, treating chondrocytes from older donors with MDL-800 for 48 hours significantly reduced the amount of baseline DNA damage. Chondrocytes isolated from the knees of mice between 4 months and 22 months of age revealed both an increase in DNA damage with aging, and a decrease in DNA damage following MDL-800 treatment. Lastly, treating murine cartilage explants with MDL-800 lowered the percentage of chondrocytes with high p16 promoter activity, which supports the concept that using SIRT6 activation to maintain low levels of DNA damage may prevent the initiation of senescence. “In conclusion, the findings presented here support the hypothesis that the efficiency of DNA damage repair declines with age in chondrocytes and that SIRT6 activation improves repair both in response to an acute irradiation challenge and in the context of age-related damage accumulation. These results emphasize the critical role of SIRT6 in DNA repair and support further studies investigating the use of MDL-800 (or alternative SIRT6 activators) in mitigating senescence induction and ameliorating OA development.” DOI - https://doi.org/10.18632/aging.205394 Corresponding author - Brian O. Diekman - bdiekman@email.unc.edu About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

Melatonin and Carcinogenesis in Mice

Play Episode Listen Later Dec 18, 2023 2:27

BUFFALO, NY- December 18, 2023 – A new research #perspective was #published in Oncotarget's Volume 14 on December 12, 2023, entitled, “Melatonin and carcinogenesis in mice: the 50th anniversary of relationships.” Fifty years ago, in 1973, Vladimir N. Anisimov and coauthors demonstrated for the first time an inhibitory effect of the pineal gland hormone melatonin on cancer in vivo, namely on transplantable mammary tumors in mice. Subsequently, it was shown in a number of studies that melatonin administration with drinking water at night inhibits chemically induced mammary carcinogenesis in mice and rats. On the contrary, maintaining female mice and rats under round-the-clock lighting conditions, which suppresses the nighttime production of melatonin, stimulates spontaneous and chemical carcinogen-induced mammary tumor development. As of today, the query “cancer AND melatonin AND mice” in Pubmed returns about 550 entries. In this new research perspective, researchers Vladimir N. Anisimov and Alexey G. Golubev from N.N. Petrov National Medical Research Center of Oncology outline the history of studies of melatonin effects on cancer in mice, with the main lesson being that the systemic in vivo effects of melatonin on animals may overwhelm the in vitro effects found using tissue explants or cell cultures. “In particular, the timing of melatonin administration is of crucial importance for using the drug, which is freely available over [the] counter and thus needs no licensing for its applications in oncology.” DOI - https://doi.org/10.18632/oncotarget.28537 Correspondence to - Vladimir N. Anisimov - aging@mail.ru Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28537 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, melatonin, mice About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

soundcloud reddit buffalo fifty mice oncology subsequently melatonin doi pubmed carcinogenesis altmetric oncotarget ny december

Unique Pathogenic Mechanism of SARS-CoV-2 Omicron Variant: Induction of Cellular Senescence

Play Episode Listen Later Dec 15, 2023 4:17

BUFFALO, NY- December 15, 2023 – A new #researchpaper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence.” SARS-CoV-2 variants are constantly emerging with a variety of changes in the conformation of the spike protein, resulting in alterations of virus entry mechanisms. Solely omicron variants use the endosomal clathrin-mediated entry. In this new study, researchers Franziska Hornung, Nilay Köse-Vogel, Claude Jourdan Le Saux, Antje Häder, Lea Herrmann, Luise Schulz, Lukáš Radosa, Thurid Lauf, Tim Sandhaus, Patrick Samson, Torsten Doenst, Daniel Wittschieber, Gita Mall, Bettina Löffler, and Stefanie Deinhardt-Emmer from Jena University, Leibniz Centre for Photonics in Infection Research (LPI), University of California San Francisco, Klinik für Herz- und Thoraxchirurgie, and University Hospital Bonn investigated the influence of defined altered spike formations to study their impact on premature cellular senescence. “In our study, in vitro infections of SARS-CoV-2 variants delta (B.1.617.2) and omicron (B.1.1.529) were analyzed by using human primary small alveolar epithelial cells and human ex vivo lung slices. We confirmed cellular senescence in human lungs of COVID-19 patients. Hence, global gene expression patterns of infected human primary alveolar epithelial cells were identified via mRNA sequencing.” Solely omicron variants of SARS-CoV-2 influenced the expression of cell cycle genes, highlighted by an increased p21 expression in human primary lung cells and human ex vivo lungs. Additionally, an upregulated senescence-associated secretory phenotype (SASP) was detected. Transcriptomic data indicate an increased gene expression of p16, and p38 in omicron-infected lung cells. Significant changes due to different SARS-CoV-2 infections in human primary alveolar epithelial cells with an overall impact on premature aging could be identified. A substantially different cellular response with an upregulation of cell cycle, inflammation- and integrin-associated pathways in omicron infected cells indicates premature cellular senescence. “This difference may be attributed to the distinct endocytic cell entry and intracellular pathways of the omicron variant when compared to the delta variant. The induction of cellular senescence in lung tissue following acute SARS-CoV-2 infection could potentially contribute to the reported cytokine storm and the development of long-COVID.” DOI - https://doi.org/10.18632/aging.205297 Corresponding author - Stefanie Deinhardt-Emmer - stefanie.deinhardt-emmer@med.uni-jena.de Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, SARS-CoV-2, variant of concern, cellular senescence, lung airway cells About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

Cytostatic Persister Cancer Cells: Therapeutic Opportunities and Challenges

Play Episode Listen Later Dec 13, 2023 2:40

BUFFALO, NY- December 13, 2023 – A new #editorial paper was #published in Oncotarget's Volume 14 on December 1, 2023, entitled, “Therapeutic potentials and challenges of cytostatic persister cancer cells.” Cancer cells that remain viable despite treatment constitute a persister condition that is implicated in residual diseases and a source from which resistant clones and relapses can emerge. Unlike resistant cells that are capable of cycling under therapy, persister cancer cells stay viable but assume a quiescent or non-proliferating state that is reversible upon treatment discontinuation. A source of persisters that has been under extensive study is drug-tolerant persisters, a small cancer cell population that can withstand the selection pressure of cytotoxic treatment and have been attributed to failure in achieving complete response. It is well-recognized that many targeted therapeutic agents possess cytostatic effects that suppress growth without directly inducing cell death. While representing favorable responses, treatment-mediated cytostatic conditions require continual maintenance and intrinsically confer an obligate persister population throughout therapy. However, few efforts have focused on understanding the properties of such cytostatic persisters and exploring their therapeutic potentials. In their new editorial, researchers Paul Y. Kim and Cheuk T. Leung from the University of Minnesota Medical School discuss recent studies from their group exploring the cellular controls in persister cancer cells under treatment-mediated cytostatic conditions and devised strategies for targeting to reduce cancer recurrence. Findings shed light on the cellular controls in cytostatic persisters and highlighted that treatment-mediated cytostatic condition before resistance emerges is a viable targeting venue to reduce cancer recurrence. “The distinct vulnerabilities of cytostatic and drug-tolerant persisters imply that administering multiple targeted regimens would be necessary to effectively deplete the persister reservoirs in patients under cancer treatments.” DOI - https://doi.org/10.18632/oncotarget.28488 Correspondence to - Cheuk Leung - ctleung@umn.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28488 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, persister cancer cells, cytostatic therapy, cancer recurrence, PTEN/PI3K/AKT, proteasome inhibitor About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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Nectandrin B for Longevity: Nectandrin B (in Nutmeg) Significantly Increases Lifespan of Fruit Flies

Play Episode Listen Later Dec 13, 2023 3:36

BUFFALO, NY- December 13, 2023 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Nectandrin B significantly increases the lifespan of Drosophila - Nectandrin B for longevity.” Phytochemicals are increasingly recognized in the field of healthy aging as potential therapeutics against various aging-related diseases. Nutmeg, derived from the Myristica fragrans tree, is an example. Nutmeg has been extensively studied and proven to possess antioxidant properties that protect against aging and alleviate serious diseases such as cancer, heart disease, and liver disease. However, the specific active ingredient in nutmeg responsible for these health benefits has not been identified thus far. In this new study, researchers Ji-Seon Ahn, Nasir Uddin Mahbub, Sura Kim, Han-Byeol Kim, Jong-Soon Choi, Hea-Jong Chung, and Seong-Tshool Hong from Korea Basic Science Institute, Jeonbuk National University Medical School and Chung-Ang University present evidence that Nectandrin B (NecB), a bioactive lignan compound isolated from nutmeg, significantly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 42.6% compared to the control group. “[...] we hypothesized that NecB might possess anti-aging efficacy.” The dramatic reduction of intracellular ROS levels by NecB captured the researchers' attention. NecB also improved age-related symptoms including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration in aging D. melanogaster. The researchers wrote that this result represents the most substantial improvement in lifespan observed in animal experiments to date, suggesting that NecB may hold promise as a potential therapeutic agent for promoting longevity and addressing age-related degeneration. “We strongly believe that NecB urgently needs further attention and research, as we believe it has made a potential contribution to our understanding of the aging process as well as its application as a potential therapeutic agent for longevity and age-related.” DOI - https://doi.org/10.18632/aging.205234 Corresponding authors - Jong-Soon Choi - jschoi@kbsi.re.kr, Hea-Jong Chung - hjchung84@kbsi.re.kr, and Seong-Tshool Hong - seonghong@jbnu.ac.kr Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205234 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, Myristica fragrans, nutmeg, Nectandrin B, lifespan, longevity About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

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Tat-Heat Shock Protein 10 Ameliorates Age-Related Phenotypes in the Hippocampus

Play Episode Listen Later Dec 12, 2023 4:19

BUFFALO, NY- December 12, 2023 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus.” In this new study, researchers Hyo Young Jung, Hyun Jung Kwon, Kyu Ri Hahn, Woosuk Kim, Dae Young Yoo, Yeo Sung Yoon, Dae Won Kim, and In Koo Hwang from Seoul National University, Chungnam National University, Gangneung-Wonju National University, Hallym University, and Konkuk University investigated the effects of heat shock protein 10 (HSP10) protein on memory function, hippocampal neurogenesis, and other related genes/proteins in adult and aged mice. “In the present study, we investigated the effects of HSP10 on hippocampal function in both adult and aged mice.” To translocate the HSP10 protein into the hippocampus, the Tat-HSP10 fusion protein was synthesized, and Tat-HSP10, not HSP10, was successfully delivered into the hippocampus based on immunohistochemistry and western blotting. Tat-HSP10 (0.5 or 2.0 mg/kg) or HSP10 (control protein, 2.0 mg/kg) was administered daily to 3- and 21-month-old mice for 3 months, and observed the senescence maker P16 was significantly increased in aged mice and the treatment with Tat-HSP10 significantly decreased P16 expression in the hippocampus of aged mice. In novel object recognition and Morris water maze tests, aged mice demonstrated decreases in exploratory preferences, exploration time, distance moved, number of object contacts, and escape latency compared to adult mice. Treatment with Tat-HSP10 significantly improved exploratory preferences, the number of object contacts, and the time spent swimming in the target quadrant in aged mice but not adults. Administration of Tat-HSP10 increased the number of proliferating cells and differentiated neuroblasts in the dentate gyrus of adult and aged mice compared to controls, as determined by immunohistochemical staining for Ki67 and doublecortin, respectively. Additionally, Tat-HSP10 treatment significantly mitigated the reduction in sirtuin 1 mRNA level, N-methyl-D-aspartate receptor 1, and postsynaptic density 95 protein levels in the hippocampus of aged mice. In contrast, Tat-HSP10 treatment significantly increased sirtuin 3 protein levels in both adult and aged mouse hippocampus. These suggest that Tat-HSP10 can potentially reduce hippocampus-related aging phenotypes. “Our results suggest that Tat-HSP10 treatment facilitates mitochondrial function, and Tat-HSP10 supplementation ameliorates the aging phenotypes in the mouse hippocampus.” DOI - https://doi.org/10.18632/aging.205182 Corresponding authors - Dae Won Kim - kimdw@gwnu.ac.kr, and In Koo Hwang - vetmed2@snu.ac.kr Keywords - aging, heat shock protein 10, hippocampus, memory, neurogenesis, synaptic plasticity About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

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Risk Factors for Long-Term Arm Morbidities Following Breast Cancer Treatments: A Systematic Review

Play Episode Listen Later Dec 11, 2023 3:04

BUFFALO, NY- December 11, 2023 – A new #review paper was #published in Oncotarget's Volume 14 on December 1, 2023, entitled, “Risk factors for long-term arm morbidities following breast cancer treatments: A systematic review.” In this review, researchers Ifat Klein, Michael Friger, Merav Ben David, and Danit Shahar from Assuta Medical Center and Ben-Gurion University of the Negev in Israel aimed to examine the risk factors for arm morbidity following breast cancer treatments. The team took a broad view of all types of physical morbidity, including prolonged pain, lymphedema, decreased range of motion, and functional limitations. “A systematic literature review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines.” Studies exploring the risk factors for prolonged arm morbidity following breast cancer surgery and treatments were included. The studies were assessed independently according to pre-eligibility criteria, following data extraction and methodological quality assessment. 1,242 articles were identified. After removing duplicates, the full texts of 1,153 articles were examined. Sixty-nine of these articles met the criteria and were included in the review. These 69 articles identified 29 risk factors for arm morbidity following treatments for breast cancer. The risk of bias was evaluated using NIH study quality assessment tools. The studies reviewed were published between 2001 and 2021 and included a total of 22,886 patients who were followed up for between three months and 10 years. The main risk factors for long-term morbidity are removal of lymph nodes from the axilla, body mass index >30, having undergone a mastectomy, the stage of the disease, radiation therapy, chemotherapy, infection and trauma to the affected arm after surgery. “An understanding of the risk factors for prolonged arm morbidity after surgery can help doctors and therapists in making personalized decisions about the need and timing of rehabilitation treatments.” DOI - https://doi.org/10.18632/oncotarget.28539 Correspondence to - Ifat Klein - ifatgoldberg@hotmail.com Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28539 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, risk factors, arm morbidity, physical rehabilitation, breast cancer About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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Advent and the Eucharistic Revival, St. Raymond of Penyafort Parish, E. Rockaway, NY, December 5, 2023

Catholic Preaching

Play Episode Listen Later Dec 6, 2023 54:14

Fr. Roger J. Landry St. Raymond of Penyafort, East Rockaway, New York Parish Night of Recollection December 5, 2023 To listen to an audio recording of tonight’s talk, please click below: https://traffic.libsyn.com/secure/catholicpreaching/12.5.23_Advent_and_the_Eucharistic_Revival.mp3 The post Advent and the Eucharistic Revival, St. Raymond of Penyafort Parish, E. Rockaway, NY, December 5, 2023 appeared first on Catholic Preaching.

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BCMA+ EV Levels Correlate With Myeloma Response to Belantamab-Mafodotin

Play Episode Listen Later Dec 6, 2023 3:41

BUFFALO, NY- December 6, 2023 – A new #researchpaper was #published in Oncotarget's Volume 14 on December 1, 2023, entitled, “Plasma levels of BCMA-positive extracellular vesicles correlate to response and side effects in myeloma patients treated with belantamab-mafodotin.” In myeloma patients, high levels of soluble B-cell maturation antigen (sBCMA) can limit the efficacy of BCMA-directed therapies. Belantamab-mafodotin is a BCMA antibody-drug conjugate and shows good overall response rates in heavily pretreated patients, but progression-free survival data are poor. In this new study, researchers Carsten Springer, Jürgen Krauter and Arne Trummer, from Städtisches Klinikum Braunschweig and Heidekreis-Klinikum in Germany, investigated whether sBCMA in blood plasma includes extracellular vesicles (EV) carrying BCMA or other myeloma antigens and if these BCMA-EV levels show a significant change during therapy with belantamab-mafodotin. “As the drug induces apoptosis, we hypothesized that sBCMA includes extracellular vesicles (EV) and thus evaluated numbers of BCMA-EV before and during belantamab therapy in 10 myeloma patients.” BCMA-EV were significantly higher in patients prior to Belantamab (median: 3227/μl; p = .013) than in other myeloma patients before therapy (n = 10; 1082/μl) or healthy volunteers (n = 10; 980/μl). During therapy, BCMA-EV showed a significant increase to a maximum of 8292/μl (p = .028). Maximal changes in BCMA-EV (Δmax = BCMA-EV at C1/maximal BCMA-EV) showed a strong inverse, logarithmic correlation (r = −.950; p < .001) with FLC ratio changes (Δmax = FLC ratio at C1/minimal FLC ratio) and BCMA-EV peaks often preceded FLC progression. Correlating increase of LDH and BCMA-EV levels, together with clinical symptoms, point to a mafodotin-induced eryptosis. In summary, BCMA-EV are a part of sBCMA, peak levels precede progression, and their measurement might be helpful in identifying resistance mechanisms and side effects of BCMA-targeted therapies. “To the best of our knowledge, we demonstrate for the first time that BCMA-positive extracellular vesicles can be found in blood plasma from myeloma patients and that BCMA expression on EV is 10 to 100 times higher than that of other well-known antigens of myeloma cells.” DOI - https://doi.org/10.18632/oncotarget.28538 Correspondence to - Arne Trummer - arne.trummer@heidekreis-klinikum.de Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28538 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, myeloma, b cell maturation antigen, extracellular vesicles, belantamab-mafodotin, eryptosis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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Artificial Intelligence for Aging Research in Cancer Drug Development

Play Episode Listen Later Dec 6, 2023 2:29

BUFFALO, NY- December 6, 2023 – A new #editorial paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Artificial intelligence for aging research in cancer drug development.” Aging is a multifactorial and complex process associated with various diseases, including cancer. In light of the growing aging population, the need for effective cancer treatments is more significant than ever. Artificial intelligence (AI) is playing an increasingly crucial role in aging research and cancer drug development in revealing the critical drivers of outcomes among a wide range of intrinsic and extrinsic factors. In recent years, the use of AI in aging research has been rapidly increasing, suggesting that AI-based analysis of healthcare data may enhance clinical care. In this new editorial, researchers Dorsa Shirini, Lawrence H. Schwartz and Laurent Dercle from Columbia University Medical Center provide an overview of the potential benefits as well as the technical caveats of adopting AI to help researchers identify new targets, develop more effective therapies, and accelerate the discovery process of drug development in the context of aging research. “In this review, we discuss how we could leverage AI technologies to consider a patient's unique aging profile and tailor cancer treatment more precisely to the individual. This approach would help optimize treatment outcomes, minimize treatment-related risks, and improve the overall quality of care for patients, considering the complex interplay between aging and cancer treatment response.” DOI - https://doi.org/10.18632/aging.204914 Corresponding authors - Laurent Dercle - ld2752@cumc.columbia.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204914 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, artificial intelligence, cancer research About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

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Membrane Raft Redox Signaling Contributes to Visfatin-Induced Inflammation and Kidney Damage

Play Episode Listen Later Dec 5, 2023 4:59

BUFFALO, NY- December 5, 2023 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Contribution of membrane raft redox signalling to visfatin-induced inflammasome activation and podocyte injury.” The number of obese patients with end stage renal disease has increased significantly worldwide in the last few decades. Obesity results in an increased risk for chronic kidney diseases like diabetes and hypertension which consequently result in chronic kidney disease or even end-stage renal disease. However, the exact mechanism of how obesity increases the advancement of chronic kidney disease is still uncertain. Recently, researchers Saisudha Koka, Sreenidhi Surineni, Gurinder Bir Singh, and Krishna M. Boini from the University of Houston, Texas A&M University and the University of California Riverside have shown that adipokine visfatin-induced NLRP3 inflammasome activation contributes to podocyte injury. However, the molecular mechanisms of how visfatin induces the Nlrp3 inflammasome activation and podocyte damage is still unknown. The present study tested whether the membrane raft (MR) redox signaling pathway plays a central role in visfatin-induced NLRP3 inflammasomes formation and activation in podocytes. “In this study, it is proposed that visfatin induces the NLRP3 inflammasome activation in podocytes, leading to glomerular inflammatory injury in the kidney and the development of CKD, may be primarily driven by NADPH oxidase-mediated membrane raft redox signalling.” Upon visfatin stimulation, an aggregation of NADPH oxidase subunits, gp91phox and p47phox, was observed in the MR clusters, forming an MR redox signaling platform in podocytes. The formation of this signaling platform was blocked by prior treatment with MR disruptor MCD or NADPH oxidase inhibitor DPI. In addition, visfatin stimulation significantly increased the colocalization of Nlrp3 with Asc or Nlrp3 with caspase-1, IL-β production, cell permeability in podocytes compared to control cells. Pretreatment with MCD, DPI, WEHD significantly abolished the visfatin-induced colocalization of NLRP3 with Asc or NLRP3 with caspase-1, IL-1β production and cell permeability in podocytes. Furthermore, Immunofluorescence analysis demonstrated that visfatin treatment significantly decreased the podocin and nephrin expression (podocyte damage) and prior treatments with DPI, WEHD, MCD attenuated this visfatin-induced podocin and nephrin reduction. In conclusion, their results suggest that visfatin stimulates membrane raft clustering in the membrane of podocytes to form redox signaling platforms by aggregation and activation of NADPH oxidase subunits enhancing O2·− production, leading to NLRP3 inflammasome activation in podocytes and ultimate podocyte injury. “Through experiments conducted on cultured podocytes, we have demonstrated, for the first time that membrane raft-associated redox signalling is essential for the NLRP3 inflammasomes assembly and activation in response to visfatin, subsequently resulting in podocyte dysfunction and injury. These findings shed light on a novel mechanism underlying inflammasome activation and injury of podocytes triggered by visfatin.” DOI - https://doi.org/10.18632/aging.205243 Corresponding author - Krishna M. Boini - kmboini@uh.edu Video short - https://www.youtube.com/watch?v=cIzaHj31GBo Visit our website at https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

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Osteopontin Induces Mitochondrial Biogenesis in Deadherent Cancer Cells

American Conservative University

Play Episode Listen Later Dec 4, 2023 2:33

BUFFALO, NY- December 4, 2023 – A new #researchpaper was #published in Oncotarget's Volume 14 on December 1, 2023, entitled, “Osteopontin induces mitochondrial biogenesis in deadherent cancer cells.” Metastasizing cells display a unique metabolism, which is very different from the Warburg effect that arises in primary tumors. Over short time frames, oxidative phosphorylation and ATP generation are prominent. Over longer time frames, mitochondrial biogenesis becomes a pronounced feature and aids metastatic success. It has not been known whether or how these two phenomena are connected. In this new study, researchers Gulimirerouzi Fnu and Georg F. Weber from the University of Cincinnati's James L. Winkle College of Pharmacy hypothesized that Osteopontin splice variants, which synergize to increase ATP levels in deadherent cells, also increase the mitochondrial mass via the same signaling mechanisms. “Here, we report that autocrine Osteopontin does indeed stimulate an increase in mitochondrial size, with the splice variant -c being more effective than the full-length form -a.” Osteopontin-c achieves this via its receptor CD44v, jointly with the upregulation and co-ligation of the chloride-dependent cystine-glutamate transporter SLC7A11. The signaling proceeds through activation of the known mitochondrial biogenesis inducer PGC-1 (which acts as a transcription coactivator). Peroxide is an important intermediate in this cascade, but surprisingly acts upstream of PGC-1 and is likely produced as a consequence of SLC7A11 recruitment and activation. In vivo, suppression of the biogenesis-inducing mechanisms leads to a reduction in disseminated tumor mass. “This study confirms a functional connection between the short-term oxidative metabolism and the longer-term mitochondrial biogenesis in cancer metastasis – both are induced by Osteopontin-c. The results imply possible mechanisms and targets for treating cancer metastasis.” DOI - https://doi.org/10.18632/oncotarget.28540 Correspondence to - Georg F. Weber - georg.weber@uc.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28540 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, metastasis, metabolism, anchorage independence, mitochondrial mass, peroxide About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

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Survivor Series Re-Cap

The Bob Culture Podcast

Play Episode Listen Later Nov 28, 2023 53:39

Check out my Survivor Series: War Games Re-cap as I make my way home from Chicago!! What did you think of WWE Survivor Series? As Always The BCP is brought to you by our FAVORITE store, Funkenstein Wrestling Superstore located in The Englishtown Flea Market (NJ) from 8 am -3pm Sat & Sunday and online. Get your favorite wrestling merch, retro games, ninja turtles, Ghosbusters, and so much more!! Please welcome in our new official sponsor, Warriors of Wrestling!! W.O.W. brings the action to Staten Island, NY December 2nd with appearances by Sonny Kiss, FKA Enzo Amore, Darius Carter, TJ Marconi, Chris Steeler, Joe Ocasio, Zayda Steele and more!! Tickets are available now at https://warriorsofwrestling.com/ and be sure to subscribe on YouTube!! Warriors Of Wrestling (W.O.W) Please welcome in our NEW sponsor, Mania Club. Established in 2015, MANIA CLUB is a WWE recognized community for fans with an eclectic love for both the world of professional wrestling and raising money for Connors Cure. During WrestleMania weekend, we host the official Tailgate of WrestleMania while also celebrating Connor Michalek. They are the single largest donor within the V Foundation for Connors Cure with over $150K raised! Please donate and join the Facebook group at Mania Club. Donate at http://JimmyV.org/maniaclub The BCP is also sponsored by The No Gimmicks Podcast !! The Pro Wrestling podcast that keeps it 100% real, 100% of the time!! The No Gimmicks Podcast is available wherever you get your podcasts. The BCP is now sponsored by The International Shining Star, Rey Calitri !! Calitri has honed his craft traveling and wrestling all over the world including destinations such as Mexico, Peru, Puerto Rico, and even Egypt. The ISPW Tri-State Champion and Golden Ticket Holder is also one of the longest reigning ECPW Light Heavyweight Champions in history. Calitri also holds an international Championship that he won in Mexico. Always known for his appreciation of world culture, The Shining Star is also known for his taste for high fashion, lavish lifestyle, and fast cars. However, he is most prominently known around the globe for his unparalleled in ring acumen and skillset. Be sure to follow Rey Calitri across the board on social media @CalitriRey on Twitter, @Pap1fresh on Instagram and Rey Calitri on Facebook. WRESTLING ALL DAY ALL NIGHT is the best wrestling discussion group on Facebook! We provide more of a community feel here, and have wrestling fans introduce other fans to something they may not have seen before, such as old school wrestling, indie wrestling, Japanese wrestling, and more! We also strive to be a source of information regarding upcoming wrestler meet & greets and signings. And remember, we're open 24/7. All Day. All Night! Be sure to follow on socials and join the group on Facebook at WRESTLING ALL DAY ALL NIGHT Sweet Chin Musings is the creation of the reigning, rarely defending, highly disputed champion of wrestling podcasts, “Mr. Perfect” Mike Mueller, and his tag team partner in crime, Luke Kudialis. SCM focuses on the in-ring product of WWE and AEW (no dirt sheet rumors here), as well as backstage news, predictions and analysis of characters, storylines, and major pay per views. Old school fans, don't worry, we have you covered too, with a look back on classic matches, top 10 lists, and interactive tournaments that let the fans decide who is truly the best of all time. You can find us on Facebook at Sweet Chin Musings , and check out the podcast at https://linktr.ee/SweetChinMusings Please welcome our new sponsor for BCP+, The United States Department of Nerds (USDN Podcast), a podcast presented by Dat Feeling Podcast Network (DFPN), LLC. The USDN Podcast is run by Jeffrey T. Fountain (BCP+ Contributor), Jennifer Johnson, Eric Johnson and Tay Stith and is also home to the Queens of Nerdom Podcast. USDN Podcast is a safe place for all Nerds where they can come to be entertained, learn and embrace debate. USDN prides itself on being for the people, by the people and of the people. Here at USDN we strive to bring you the best content we can find where you know, it comes with the USDN Seal of Approval! We always strive to give you factual data and if it's a rumor we will always preface it with RUMOR ALERT before dropping the freshest info. However, once those rumors are proven TRUE, you can bet your money we at USDN are slamming the stamp down and giving it the USDN seal of approval. Hit our link for all our social media and merch! This ad is USDN Podcast Approved!! https://linktr.ee/USDN_Podcast Please welcome in our NEW pod sponsor for the show GPW Productions !! GPW provides your promotion or event with TOP TIER video, audio, production, live streaming, and more!! I can personally vouch for them in saying they are hands down THE BEST Production company I have ever worked with as they have and continue to work with the likes of AEW, GCW, Starrcast, MLW, not to mention the majority of the local independent Promotions in the tri-state area. They can even help you film a vignette or promo for your persona/gimmick. And guess what? GPW doesn't just work in wrestling. They cover MMA, boxing, basketball, or any other sporting event as well!! On a personal note I'd like to thank Michael James Sesko , Frank León , Oneil Andrews & the team for giving me multiple opportunities to work with them and some of the best talent in the world. BOOK GPW for your promotion or event today at contact@gpwproductions.com Thank you to our NEW November sponsor on the pod and site, The Rock & Wrestling Collector located in Stockholm, NJ featuring all your favorite rock AND Wrestling Collectibles, owned by ISPW Head Honcho Mr. Tommy Fierro. The Rock & Wrestling Collector makes it's GRAND OPENING on BLACK FRIDAY!! Don't miss it and be sure to follow @THEWCSTORE and @80swrestling on socials!! Let's ROCK!! The Wrestling Collector, LLC Please welcome in our new pod sponsor for the month of November, Pro Wrestling Magic !! PWM presents "Holiday Road to Kingdom Come" at the Mecca (Ridgefield Park, NJ) and streaming on IWTV on November 25th!! Featuring Cheeseburger, Darius Carter , Adena Steele , Ruthless Lala , Steve Pena , Kerr , Vinny Pacifico , Death Row, Hispanos Unidos, and more!! Get your tickets now!! Please welcome in our NEW sponsor for the month of November, Savage Kingdom presents an epic Swerve Strickland signing on December 29th in Flushing, NY. Come Meet & Greet one of AEW 's Top stars, podcast host, and musician over at The Wrestling Universe!! Pre-purchase tickets are available now. On a personal note, thank you Greek Savage for the support and always helping with our charitable endeavors. Please welcome in our new sponsors for The Podcast & The Site, Crusaders Collectibles - Wrestling Games Lives Signings and More and WRESTLING COLLECTORS FEDERATION on Facebook!! Crusaders Collectibles is your destination for some of the best signings, live sale, games, and more. We are mostly wrestling, but you may see other items at times. We are a family here and want everyone treated like family. You will be able to find custom edits, photos, figures, cards, belts, pops and more here. many of those will even be autographed!! Wrestling Collectors Federation on Facebook features amazing auctions, sales, pick events, and even mystery drawings for some truly unique items for any serious wrestling Collector!! Be sure to join the group and get in and the fun. On a personal note I'd like to thank Emile for all his support of the BCP and our charitable endeavors. Please welcome in our new pod Sponsors for the month of November Bubba John Kim And Gabby, BKG. This fam consistently shows their love and support for wrestlers on both the independent and national level reminding us what this really is all about. Bubba has been a strong supporter of the BCP, primarily in our charity work, donating multiple items, time and effort. Thank you BKG

WWE SURVIVOR SERIES PICKS 2023

The Bob Culture Podcast

Play Episode Listen Later Nov 25, 2023 86:26

Join the panel as we make our full #WWE #SurvivorSeries Picks and let us know who YOU got!! As Always The BCP is brought to you by our FAVORITE store, Funkenstein Wrestling Superstore located in The Englishtown Flea Market (NJ) from 8 am -3pm Sat & Sunday and online. Get your favorite wrestling merch, retro games, ninja turtles, Ghostbusters, and so much more!! Please welcome in our new official sponsor, Warriors of Wrestling!! W.O.W. brings the action to Staten Island, NY December 2nd with appearances by Sonny Kiss, FKA Enzo Amore, Darius Carter, TJ Marconi, Chris Steeler, Joe Ocasio, Zayda Steele and more!! Tickets are available now at https://warriorsofwrestling.com/ and be sure to subscribe on YouTube!! Warriors Of Wrestling (W.O.W) Please welcome in our NEW sponsor, Mania Club. Established in 2015, MANIA CLUB is a WWE recognized community for fans with an eclectic love for both the world of professional wrestling and raising money for Connors Cure. During WrestleMania weekend, we host the official Tailgate of WrestleMania while also celebrating Connor Michalek. They are the single largest donor within the V Foundation for Connors Cure with over $150K raised! Please donate and join the Facebook group at Mania Club. Donate at http://JimmyV.org/maniaclub The BCP is also sponsored by The No Gimmicks Podcast !! The Pro Wrestling podcast that keeps it 100% real, 100% of the time!! The No Gimmicks Podcast is available wherever you get your podcasts. The BCP is now sponsored by The International Shining Star, Rey Calitri !! Calitri has honed his craft traveling and wrestling all over the world including destinations such as Mexico, Peru, Puerto Rico, and even Egypt. The ISPW Tri-State Champion and Golden Ticket Holder is also one of the longest reigning ECPW Light Heavyweight Champions in history. Calitri also holds an international Championship that he won in Mexico. Always known for his appreciation of world culture, The Shining Star is also known for his taste for high fashion, lavish lifestyle, and fast cars. However, he is most prominently known around the globe for his unparalleled in ring acumen and skillset. Be sure to follow Rey Calitri across the board on social media @CalitriRey on Twitter, @Pap1fresh on Instagram and Rey Calitri on Facebook. WRESTLING ALL DAY ALL NIGHT is the best wrestling discussion group on Facebook! We provide more of a community feel here, and have wrestling fans introduce other fans to something they may not have seen before, such as old school wrestling, indie wrestling, Japanese wrestling, and more! We also strive to be a source of information regarding upcoming wrestler meet & greets and signings. And remember, we're open 24/7. All Day. All Night! Be sure to follow on socials and join the group on Facebook at WRESTLING ALL DAY ALL NIGHT Sweet Chin Musings is the creation of the reigning, rarely defending, highly disputed champion of wrestling podcasts, “Mr. Perfect” Mike Mueller, and his tag team partner in crime, Luke Kudialis. SCM focuses on the in-ring product of WWE and AEW (no dirt sheet rumors here), as well as backstage news, predictions and analysis of characters, storylines, and major pay per views. Old school fans, don't worry, we have you covered too, with a look back on classic matches, top 10 lists, and interactive tournaments that let the fans decide who is truly the best of all time. You can find us on Facebook at Sweet Chin Musings , and check out the podcast at https://linktr.ee/SweetChinMusings Please welcome our new sponsor for BCP+, The United States Department of Nerds (USDN Podcast), a podcast presented by Dat Feeling Podcast Network (DFPN), LLC. The USDN Podcast is run by Jeffrey T. Fountain (BCP+ Contributor), Jennifer Johnson, Eric Johnson and Tay Stith and is also home to the Queens of Nerdom Podcast. USDN Podcast is a safe place for all Nerds where they can come to be entertained, learn and embrace debate. USDN prides itself on being for the people, by the people and of the people. Here at USDN we strive to bring you the best content we can find where you know, it comes with the USDN Seal of Approval! We always strive to give you factual data and if it's a rumor we will always preface it with RUMOR ALERT before dropping the freshest info. However, once those rumors are proven TRUE, you can bet your money we at USDN are slamming the stamp down and giving it the USDN seal of approval. Hit our link for all our social media and merch! This ad is USDN Podcast Approved!! https://linktr.ee/USDN_Podcast Please welcome in our NEW pod sponsor for the show GPW Productions !! GPW provides your promotion or event with TOP TIER video, audio, production, live streaming, and more!! I can personally vouch for them in saying they are hands down THE BEST Production company I have ever worked with as they have and continue to work with the likes of AEW, GCW, Starrcast, MLW, not to mention the majority of the local independent Promotions in the tri-state area. They can even help you film a vignette or promo for your persona/gimmick. And guess what? GPW doesn't just work in wrestling. They cover MMA, boxing, basketball, or any other sporting event as well!! On a personal note I'd like to thank Michael James Sesko , Frank León , Oneil Andrews & the team for giving me multiple opportunities to work with them and some of the best talent in the world. BOOK GPW for your promotion or event today at contact@gpwproductions.com Thank you to our NEW November sponsor on the pod and site, The Rock & Wrestling Collector located in Stockholm, NJ featuring all your favorite rock AND Wrestling Collectibles, owned by ISPW Head Honcho Mr. Tommy Fierro. The Rock & Wrestling Collector makes it's GRAND OPENING on BLACK FRIDAY!! Don't miss it and be sure to follow @THEWCSTORE and @80swrestling on socials!! Let's ROCK!! The Wrestling Collector, LLC Please welcome in our new pod sponsor for the month of November, Pro Wrestling Magic !! PWM presents "Holiday Road to Kingdom Come" at the Mecca (Ridgefield Park, NJ) and streaming on IWTV on November 25th!! Featuring Cheeseburger, Darius Carter , Adena Steele , Ruthless Lala , Steve Pena , Kerr , Vinny Pacifico , Death Row, Hispanos Unidos, and more!! Get your tickets now!! Please welcome in our NEW sponsor for the month of November, Savage Kingdom presents an epic Swerve Strickland signing on December 29th in Flushing, NY. Come Meet & Greet one of AEW 's Top stars, podcast host, and musician over at The Wrestling Universe!! Pre-purchase tickets are available now. On a personal note, thank you Greek Savage for the support and always helping with our charitable endeavors. Please welcome in our new sponsors for The Podcast & The Site, Crusaders Collectibles - Wrestling Games Lives Signings and More and WRESTLING COLLECTORS FEDERATION on Facebook!! Crusaders Collectibles is your destination for some of the best signings, live sale, games, and more. We are mostly wrestling, but you may see other items at times. We are a family here and want everyone treated like family. You will be able to find custom edits, photos, figures, cards, belts, pops and more here. many of those will even be autographed!! Wrestling Collectors Federation on Facebook features amazing auctions, sales, pick events, and even mystery drawings for some truly unique items for any serious wrestling Collector!! Be sure to join the group and get in and the fun. On a personal note I'd like to thank Emile for all his support of the BCP and our charitable endeavors. Please welcome in our new pod Sponsors for the month of November Bubba John Kim And Gabby, BKG. This fam consistently shows their love and support for wrestlers on both the independent and national level reminding us what this really is all about. Bubba has been a strong supporter of the BCP, primarily in our charity work, donating multiple items, time and effort. Thank you BKG.

Trey Felipe Interview

The Bob Culture Podcast

Play Episode Listen Later Nov 25, 2023 50:13

Ahead of his match against Kerr at Pro Wrestling Magic Presents "Holiday Road to Kingdom Come" this Saturday at the Mecca and streaming LIVE ON IWTV, 1/3 of the Tri-Wizard Champions, member of Hispanos Unidos, and the always high flying Trey Felipe joins the show to talk about gold, personal goals, what a win over the likes of a Kerr would mean, and so much more!! Tune in!! As Always The BCP is brought to you by our FAVORITE store, Funkenstein Wrestling Superstore located in The Englishtown Flea Market (NJ) from 8 am -3pm Sat & Sunday and online. Get your favorite wrestling merch, retro games, ninja turtles, Ghosbusters, and so much more!! Please welcome in our new official sponsor, Warriors of Wrestling!! W.O.W. brings the action to Staten Island, NY December 2nd with appearances by Sonny Kiss, FKA Enzo Amore, Darius Carter, TJ Marconi, Chris Steeler, Joe Ocasio, Zayda Steele and more!! Tickets are available now at https://warriorsofwrestling.com/ and be sure to subscribe on YouTube!! Warriors Of Wrestling (W.O.W) Please welcome in our NEW sponsor, MANIA CLUB . Established in 2015, Mania Club is a WWE recognized community for fans with an eclectic love for both the world of professional wrestling and raising money for Connors Cure. During WrestleMania weekend, we host the official Tailgate of WrestleMania while also celebrating Connor Michalek. They are the single largest donor within the V Foundation for Connors Cure with over $150K raised! Please donate and join the Facebook group at Mania Club. Donate at http://JimmyV.org/maniaclub The BCP is also sponsored by The No Gimmicks Podcast !! The Pro Wrestling podcast that keeps it 100% real, 100% of the time!! The No Gimmicks Podcast is available wherever you get your podcasts. The BCP is now sponsored by The International Shining Star, Rey Calitri !! Calitri has honed his craft traveling and wrestling all over the world including destinations such as Mexico, Peru, Puerto Rico, and even Egypt. The ISPW Tri-State Champion and Golden Ticket Holder is also one of the longest reigning ECPW Light Heavyweight Champions in history. Calitri also holds an international Championship that he won in Mexico. Always known for his appreciation of world culture, The Shining Star is also known for his taste for high fashion, lavish lifestyle, and fast cars. However, he is most prominently known around the globe for his unparalleled in ring acumen and skillset. Be sure to follow Rey Calitri across the board on social media @CalitriRey on Twitter, @Pap1fresh on Instagram and Rey Calitri on Facebook. WRESTLING ALL DAY ALL NIGHT is the best wrestling discussion group on Facebook! We provide more of a community feel here, and have wrestling fans introduce other fans to something they may not have seen before, such as old school wrestling, indie wrestling, Japanese wrestling, and more! We also strive to be a source of information regarding upcoming wrestler meet & greets and signings. And remember, we're open 24/7. All Day. All Night! Be sure to follow on socials and join the group on Facebook at WRESTLING ALL DAY ALL NIGHT Sweet Chin Musings is the creation of the reigning, rarely defending, highly disputed champion of wrestling podcasts, “Mr. Perfect” Mike Mueller, and his tag team partner in crime, Luke Kudialis. SCM focuses on the in-ring product of WWE and AEW (no dirt sheet rumors here), as well as backstage news, predictions and analysis of characters, storylines, and major pay per views. Old school fans, don't worry, we have you covered too, with a look back on classic matches, top 10 lists, and interactive tournaments that let the fans decide who is truly the best of all time. You can find us on Facebook at Sweet Chin Musings , and check out the podcast at https://linktr.ee/SweetChinMusings Please welcome our new sponsor for BCP+, The United States Department of Nerds (USDN Podcast), a podcast presented by Dat Feeling Podcast Network (DFPN), LLC. The USDN Podcast is run by Jeffrey T. Fountain (BCP+ Contributor), Jennifer Johnson, Eric Johnson and Tay Stith and is also home to the Queens of Nerdom Podcast. USDN Podcast is a safe place for all Nerds where they can come to be entertained, learn and embrace debate. USDN prides itself on being for the people, by the people and of the people. Here at USDN we strive to bring you the best content we can find where you know, it comes with the USDN Seal of Approval! We always strive to give you factual data and if it's a rumor we will always preface it with RUMOR ALERT before dropping the freshest info. However, once those rumors are proven TRUE, you can bet your money we at USDN are slamming the stamp down and giving it the USDN seal of approval. Hit our link for all our social media and merch! This ad is USDN Approved!! https://linktr.ee/USDN_Podcast USDN Podcast Please welcome in our NEW pod sponsor for the show GPW Productions !! GPW provides your promotion or event with TOP TIER video, audio, production, live streaming, and more!! I can personally vouch for them in saying they are hands down THE BEST Production company I have ever worked with as they have and continue to work with the likes of AEW, GCW, Starrcast, MLW, not to mention the majority of the local independent Promotions in the tri-state area. They can even help you film a vignette or promo for your persona/gimmick. And guess what? GPW doesn't just work in wrestling. They cover MMA, boxing, basketball, or any other sporting event as well!! On a personal note I'd like to thank Michael James Sesko , Frank León , Oneil Andrews & the team for giving me multiple opportunities to work with them and some of the best talent in the world. BOOK GPW for your promotion or event today at contact@gpwproductions.com Thank you to our NEW November sponsor on the pod and site, The Rock & Wrestling Collector located in Stockholm, NJ featuring all your favorite rock AND Wrestling Collectibles, owned by ISPW Head Honcho Mr. Tommy Fierro. The Rock & Wrestling Collector makes it's GRAND OPENING on BLACK FRIDAY!! Don't miss it and be sure to follow @THEWCSTORE and @80swrestling on socials!! Let's ROCK!! The Wrestling Collector, LLC Please welcome in our new pod sponsor for the month of November, Pro Wrestling Magic !! PWM presents "Holiday Road to Kingdom Come" at the Mecca (Ridgefield Park, NJ) and streaming on IWTV on November 25th!! Featuring Cheeseburger, Darius Carter , Adena Steele , Ruthless Lala , Steve Pena , Kerr , Vinny Pacifico , Death Row, Hispanos Unidos, and more!! Get your tickets now!! Please welcome in our NEW sponsor for the month of November, Savage Kingdom presents an epic Swerve Strickland signing on December 29th in Flushing, NY. Come Meet & Greet one of AEW 's Top stars, podcast host, and musician over at The Wrestling Universe!! Pre-purchase tickets are available now. On a personal note, thank you Greek Savage for the support and always helping with our charitable endeavors. Please welcome in our new sponsors for The Podcast & The Site, Crusaders Collectibles - Wrestling Games Lives Signings and More and WRESTLING COLLECTORS FEDERATION on Facebook!! Crusaders Collectibles is your destination for some of the best signings, live sale, games, and more. We are mostly wrestling, but you may see other items at times. We are a family here and want everyone treated like family. You will be able to find custom edits, photos, figures, cards, belts, pops and more here. many of those will even be autographed!! Wrestling Collectors Federation on Facebook features amazing auctions, sales, pick events, and even mystery drawings for some truly unique items for any serious wrestling Collector!! Be sure to join the group and get in and the fun. On a personal note I'd like to thank Emile for all his support of the BCP and our charitable endeavors. Please welcome in our new pod Sponsors for the month of November Bubba John Kim And Gabby, BKG. This fam consistently shows their love and support for wrestlers on both the independent and national level reminding us what this really is all about. Bubba has been a strong supporter of the BCP, primarily in our charity work, donating multiple items, time and effort. Thank you BKG.

Whisper in the WIngs Episode 287

Stage Whisper

Play Episode Listen Later Nov 17, 2023 17:35

We have a great new Whisper in the Wings from Stage Whisper in store for you, and a perfect one for kicking off the holiday season. Joining us on this episode was performing artist, Jessica Lynn. We spoke about her amazing concert series touring the New England area, Jessica Lynn's A Very Merry Country Christmas. This was such a wonderful and joyous conversation that you won't want to miss. And speaking of things not to miss, don't miss your chance to catch this amazing show!Jessica Lynn's A Very Merry Country ChristmasMonday, December 11th @ The Palace Theatre (Syracuse, NY)December 16th-17th @ The Paramount Theater (Peekskill, NY)Tickets and more information are available at jessicalynnmusic.org/showsAnd be sure to follow Jessica to stay up to date on all her upcoming projects and productions:jessicalynnmusic.org and @jessicalynnmusic

new england wings whispers jessica lynn ny december

Dennis Prager- The Left is Destroying Western Civilization.

Play Episode Listen Later Jun 22, 2023 45:11

Dennis Prager- The Left is Destroying Western Civilization | Reclaiming Conservatism Conference Watch this speech at- https://youtu.be/fSpwSEVpk3I National Conservatism 376,431 views Aug 6, 2021 Dennis Prager Keynote Address at the Reclaiming Conservatism Conference in Glen Cove, NY- December 19, 2016. Dennis Prager is a best-selling author, nationally syndicated radio talk show host in the USA and co-founder of the internet phenomenon, PragerU. -------------------------------------------------------------------- Visit Pragertopia https://pragertopia.com/member/signup.php The first month is 99 cents. After the first month the cost is $7.50 per month. If you can afford to pay for only one podcast, this is the one we recommend. It is the best conservative radio show out there, period. ACU strongly recommends ALL ACU students and alumni subscribe to Pragertopia. Do it today! You can listen to Dennis from 9 a.m. to Noon (Pacific) Monday thru Friday, live on the Internet http://www.dennisprager.com/pages/listen ------------------------------------------------------------------------ For a great archive of Prager University videos visit- https://www.youtube.com/user/PragerUniversity/featured Donate today to PragerU! http://l.prageru.com/2eB2p0h Get PragerU bonus content for free! https://www.prageru.com/bonus-content Download Pragerpedia on your iPhone or Android! Thousands of sources and facts at your fingertips. iPhone: http://l.prageru.com/2dlsnbG Android: http://l.prageru.com/2dlsS5e Join Prager United to get new swag every quarter, exclusive early access to our videos, and an annual TownHall phone call with Dennis Prager! http://l.prageru.com/2c9n6ys Join PragerU's text list to have these videos, free merchandise giveaways and breaking announcements sent directly to your phone! https://optin.mobiniti.com/prageru Do you shop on Amazon? Click https://smile.amazon.com and a percentage of every Amazon purchase will be donated to PragerU. Same great products. Same low price. Shopping made meaningful. VISIT PragerU! https://www.prageru.com FOLLOW us! Facebook: https://www.facebook.com/prageru Twitter: https://twitter.com/prageru Instagram: https://instagram.com/prageru/ PragerU is on Snapchat! JOIN PragerFORCE! For Students: http://l.prageru.com/2aozfkP JOIN our Educators Network! http://l.prageru.com/2aoz2y9 -------------------------------------------------------------------- The Rational Bible: Exodus by Dennis Prager NATIONAL BESTSELLER "Dennis Prager has put together one of the most stunning commentaries in modern times on the most profound document in human history. It's a must-read that every person, religious and non-religious, should buy and peruse every night before bed. It'll make you think harder, pray more ardently, and understand your civilization better." — Ben Shapiro, host of "The Ben Shapiro Show" "Dennis Prager's commentary on Exodus will rank among the greatest modern Torah commentaries. That is how important I think it is. And I am clearly not alone... It might well be on its way to becoming the most widely read Torah commentary of our time—and by non-Jews as well as by Jews." — Rabbi Joseph Telushkin, bestselling author of Jewish Literacy Why do so many people think the Bible, the most influential book in world history, is outdated? Why do our friends and neighbors – and sometimes we ourselves – dismiss the Bible as irrelevant, irrational, immoral, or all of these things? This explanation of the Book of Exodus, the second book of the Bible, will demonstrate that the Bible is not only powerfully relevant to today's issues, but completely consistent with rational thought. Do you think the Bible permitted the trans-Atlantic slave trade? You won't after reading this book. Do you struggle to love your parents? If you do, you need this book. Do you doubt the existence of God because belief in God is “irrational?” This book will give you reason after reason to rethink your doubts. The title of this commentary is, “The Rational Bible” because its approach is entirely reason-based. The reader is never asked to accept anything on faith alone. As Prager says, “If something I write does not make rational sense, I have not done my job.” The Rational Bible is the fruit of Dennis Prager's forty years of teaching the Bible to people of every faith, and no faith. On virtually every page, you will discover how the text relates to the contemporary world and to your life. His goal: to change your mind – and then change your life. Highly Recommended by ACU. Purchase his book at- https://www.amazon.com/Rational-Bible-Exodus-Dennis-Prager/dp/1621577724 The Rational Bible: Genesis by Dennis Prager USA Today bestseller Publishers Weekly bestseller Wall Street Journal bestseller Many people today think the Bible, the most influential book in world history, is not only outdated but irrelevant, irrational, and even immoral. This explanation of the Book of Genesis, the first book of the Bible, demonstrates clearly and powerfully that the opposite is true. The Bible remains profoundly relevant—both to the great issues of our day and to each individual life. It is the greatest moral guide and source of wisdom ever written. Do you doubt the existence of God because you think believing in God is irrational? This book will give you many reasons to rethink your doubts. Do you think faith and science are in conflict? You won't after reading this commentary on Genesis. Do you come from a dysfunctional family? It may comfort you to know that every family discussed in Genesis was highly dysfunctional! The title of this commentary is “The Rational Bible” because its approach is entirely reason-based. The reader is never asked to accept anything on faith alone. In Dennis Prager's words, “If something I write is not rational, I have not done my job.” The Rational Bible is the fruit of Dennis Prager's forty years of teaching the Bible—whose Hebrew grammar and vocabulary he has mastered—to people of every faith and no faith at all. On virtually every page, you will discover how the text relates to the contemporary world in general and to you personally. His goal: to change your mind—and, as a result, to change your life. The Rational Bible: Deuteronomy: God, Blessings, and Curses by Dennis Prager Is the Bible, the most influential book in world history, still relevant? Why do people dismiss it as being irrelevant, irrational, immoral, or all of these things? This explanation of the Book of Deuteronomy, the fifth book of the Bible, will demonstrate how it remains profoundly relevant - both to the great issues of our day and to each individual life. Do you doubt the existence of God because you think believing in God is irrational? This book will cause you to reexamine your doubts. The title of this commentary is The Rational Bible because its approach is entirely reason-based. The listener is never asked to accept anything on faith alone. In Dennis Prager's words, “If something I write is not rational, I have not done my job.” The Rational Bible is the fruit of Prager's forty years of teaching to people of every faith and no faith at all. In virtually every section, you will discover how the text relates to the contemporary world in general and to you on a personal level. His goal: to change your mind - and, as a result, to change your life.

Episode 134: High Tea Dance . Volume 3 . East Chatham, NY . December 31, 2022

DJ Joe D'Espinosa's Podcast

Play Episode Listen Later Jan 8, 2023 97:37

Recorded live at a private event in upstate New York in the 90 minutes leading up to the turn of the New Year!

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For the First Time in Forever!

Getting Real with Bossy

Play Episode Listen Later Nov 29, 2022 40:42

Ep #11 Kelly M, Kelly B and Jazzy T are joined by Disney's "Princess Anna"! Whether you are a traveling performer, a business owner or a mother with a do-to-list a mile long, you have to find a way to spend quality time with your family. In this episode the ladies get real about the struggles of finding the time and space to get the whole family together for a night out. This may mean taking up a new sport in your 40's, jet-setting across the globe to follow your dreams or simply buying a ticket to Disney on Ice and putting your phone on do-not-disturb! ABOUT THE GUEST Ida Sjolin is cast as "Princess Anna" in Disney on Ice: Find Your Hero. She began her career as a competitive ice skater in Sweden. She joined Disney on Ice as part of the ensemble in 2017. DISNEY ON ICE PRESENTS: FIND YOUR HERO In Rochester, NY December 15 - 18 2022 at the Blue Cross Arena Tickets at www.Disneyonice.com Thank you to our Sponsors: Gallery Salon 4 Elton Street, Rochester, NY 14607 www.galleryhair.com Salena's Mexican Restaurant at Village Gate 302 N Goodman St, Rochester, NY 14607 Union Tavern 4565 Culver Rd, Rochester, NY 14622 Other episodes you'll enjoy: Wonder Woman & Her Husband: The Story of Angelina Hilton World-Changing Chocolate with Lindsay Tarnoff Handle Stress Before It Handles You | Living the Front Seat Life Podcast MUSIC: “Do It" by Infraction , “At the Hotel” by Paul Youdin "You are the Best" by Cutesy Chamber Ensemble "Mariachi" by Danijel Zambo PRODUCTION: JazzCast Pros "Just press record and leave the techy stuff to us" This episode is supported by Riverside.fm, the leading platform to record studio quality audio or video podcasts. Visit Riverside.FM and use promo code JAZZYCAST to get 2 HOURS of FREE Remote recording and 15% off a membership plan.

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Emmet Cohen • Uptown in Orbit ©️ Mack Avenue 2022 #jazz

JAZZ по-русски

Play Episode Listen Later Nov 13, 2022 14:28

Первый альбом Future Stride на лейбле Mack Avenue молодого пианиста, композитора и педагога Emmet Cohen я обозревал в прошлом году. Внимательно слежу за его активностью на Фэйсбуке, где он проводит лайв-стримы прямо из своего дома в Гарлеме. На основе таких домашних джемов и родился новый альбом Uptown in Orbit. Название отсылает нас к альбому 1960 года Blues in Orbit и намекает на Duke Ellington, где он так же дает возможность музыкантам вести себя свободно, отступать от аранжировок, как это бывает при свободных импровизациях на джем-сейшенах. Здесь так же, как и в предыдущем альбоме половина оригиналов и половина произведений других авторов, одно из которых написал басист. Чувствуется хорошая сыгранность основного трио и это результат постоянных выступлений на публике по всему миру. По стилям тут кроме страйда, свинга и мейнстрима есть еще и бибоп, который явно показывает виртуозность и прогресс не только самого лидера, но и его спутников и делает этот альбом более разнообразным и привлекательным. ©️ Mack Avenue 2022 Emmet Cohen - piano Russell Hall - acoustic bass Kyle Poole - drums Patrick Bartley - alto sax 2, 3, 6, 7, 8 Sean Jones - trumpet 2, 3, 6, 7, 8 Recorded at Sear Sound • New York, NY • December 1-2, 2021 #jazz --- Send in a voice message: https://anchor.fm/konstantins/message

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Kentucky Wildcats Basketball Season Preview 2022-2023 | The College Basketball Experience (Ep. 215)

Play Episode Listen Later Nov 6, 2022 28:32

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Kentucky Wildcats. Pick Dundee aka (@TheColbyD) and Ryan McIntyre (@Moneyline_Mac) break down the Kentucky roster and highlight what they did in recruiting and the transfer portal this offseason. Can the Wildcats cut down the nets in Houston come April? OUTGOING 6'3 G TyTy Washington (13 pts, 4 reb, 4 ast) 6'5 G Kellan Grady (11 pts, 2 reb) 6'7 F Keion Brooks (11 pts, 4 reb) 6'3 G Davion Mintz (9 pts, 2 reb) INCOMING 6'5 G Antonio Reeves (Transfer from Illinois St - 20 pts, 4 reb, 39% 3pt) 6'4 G Cason Wallace (Freshman from Dallas, TX - Ranked #8) 6'6 F Chris Livingston (Freshman from Akron, OH - Ranked #12) 7'0 C Ugonna Onyenso (Freshman from Nigeria - Ranked #39) 6'6 G Abou Thiero (Freshman from Leetsdale, PA - Ranked #166) Projected Roster Starting 5 1 – 5'9 SR. Shavir Wheeler (10 pts, 7 ast, 3 reb) 2 – 6'4 FR. Cason Wallace (Freshman from Dallas, TX - Ranked #8) 3 – 6'6 FR. Chris Livingston (Freshman from Akron, OH - Ranked #12) 4 – 6'9 SR. Jacob Toppin (18 pts, 6 reb) 5 – 6'9 SR. Oscar Tshiebwe (17 pts, 15 reb, 2 blks) Preseason Tournament: No Preseason Tournament. Rest of Non-Conference Schedule: November 7th – Howard November 11th – Duquesne November 15th – vs Michigan St (Champions Classic in Indianapolis, IN) November 17th – South Carolina St November 20th - at Gonzaga November 23rd – North Florida November 29th - Bellarmine December 4th – vs Michigan (London Showcase) December 10th – Yale December 17th – vs UCLA (New York City, NY) December 21st - Florida A&M January 28th - at Kansas SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Kentucky Wildcats Basketball Season Preview 2022-2023 (Ep. 215)

Play Episode Listen Later Nov 6, 2022 27:47

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Kentucky Wildcats. Pick Dundee aka (@TheColbyD) and Ryan McIntyre (@Moneyline_Mac) break down the Kentucky roster and highlight what they did in recruiting and the transfer portal this offseason. Can the Wildcats cut down the nets in Houston come April?OUTGOING 6'3 G TyTy Washington (13 pts, 4 reb, 4 ast) 6'5 G Kellan Grady (11 pts, 2 reb) 6'7 F Keion Brooks (11 pts, 4 reb) 6'3 G Davion Mintz (9 pts, 2 reb) INCOMING 6'5 G Antonio Reeves (Transfer from Illinois St - 20 pts, 4 reb, 39% 3pt) 6'4 G Cason Wallace (Freshman from Dallas, TX - Ranked #8) 6'6 F Chris Livingston (Freshman from Akron, OH - Ranked #12) 7'0 C Ugonna Onyenso (Freshman from Nigeria - Ranked #39) 6'6 G Abou Thiero (Freshman from Leetsdale, PA - Ranked #166) Projected RosterStarting 51 – 5'9 SR. Shavir Wheeler (10 pts, 7 ast, 3 reb)2 – 6'4 FR. Cason Wallace (Freshman from Dallas, TX - Ranked #8)3 – 6'6 FR. Chris Livingston (Freshman from Akron, OH - Ranked #12)4 – 6'9 SR. Jacob Toppin (18 pts, 6 reb)5 – 6'9 SR. Oscar Tshiebwe (17 pts, 15 reb, 2 blks)Preseason Tournament:No Preseason Tournament.Rest of Non-Conference Schedule:November 7th – HowardNovember 11th – DuquesneNovember 15th – vs Michigan St (Champions Classic in Indianapolis, IN)November 17th – South Carolina StNovember 20th - at GonzagaNovember 23rd – North FloridaNovember 29th - BellarmineDecember 4th – vs Michigan (London Showcase)December 10th – YaleDecember 17th – vs UCLA (New York City, NY)December 21st - Florida A&MJanuary 28th - at KansasSGPN Merch Store - https://sg.pn/storeDownload The Free SGPN App - https://sgpn.appWynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBETSupport for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Follow The College Experience & SGPN On Social MediaTwitter - https://twitter.com/TCEonSGPNTwitter - http://www.twitter.com/gamblingpodcastInstagram - http://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social MediaColby Dant - http://www.twitter.com/thecolbydPatty C - https://twitter.com/PattyC831NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling PodcastYouTube - https://www.sg.pn/YouTubeTwitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversationWebsite - https://www.sportsgamblingpodcast.comDiscord - https://sg.pn/discordReddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Kentucky Wildcats Basketball Season Preview 2022-2023 (Ep. 215)

Play Episode Listen Later Nov 6, 2022 28:32

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Kentucky Wildcats. Pick Dundee aka (@TheColbyD) and Ryan McIntyre (@Moneyline_Mac) break down the Kentucky roster and highlight what they did in recruiting and the transfer portal this offseason. Can the Wildcats cut down the nets in Houston come April? OUTGOING 6'3 G TyTy Washington (13 pts, 4 reb, 4 ast) 6'5 G Kellan Grady (11 pts, 2 reb) 6'7 F Keion Brooks (11 pts, 4 reb) 6'3 G Davion Mintz (9 pts, 2 reb) INCOMING 6'5 G Antonio Reeves (Transfer from Illinois St - 20 pts, 4 reb, 39% 3pt) 6'4 G Cason Wallace (Freshman from Dallas, TX - Ranked #8) 6'6 F Chris Livingston (Freshman from Akron, OH - Ranked #12) 7'0 C Ugonna Onyenso (Freshman from Nigeria - Ranked #39) 6'6 G Abou Thiero (Freshman from Leetsdale, PA - Ranked #166) Projected Roster Starting 5 1 – 5'9 SR. Shavir Wheeler (10 pts, 7 ast, 3 reb) 2 – 6'4 FR. Cason Wallace (Freshman from Dallas, TX - Ranked #8) 3 – 6'6 FR. Chris Livingston (Freshman from Akron, OH - Ranked #12) 4 – 6'9 SR. Jacob Toppin (18 pts, 6 reb) 5 – 6'9 SR. Oscar Tshiebwe (17 pts, 15 reb, 2 blks) Preseason Tournament: No Preseason Tournament. Rest of Non-Conference Schedule: November 7th – Howard November 11th – Duquesne November 15th – vs Michigan St (Champions Classic in Indianapolis, IN) November 17th – South Carolina St November 20th - at Gonzaga November 23rd – North Florida November 29th - Bellarmine December 4th – vs Michigan (London Showcase) December 10th – Yale December 17th – vs UCLA (New York City, NY) December 21st - Florida A&M January 28th - at Kansas SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Oklahoma State Cowboys Basketball Season Preview 2022-2023 | The College Basketball Experience (Ep. 191)

Play Episode Listen Later Oct 14, 2022 39:20

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Oklahoma State Cowboys. Pick Dundee aka (@TheColbyD) and Ryan McIntyre (@Moneyline_Mac) break down the Oklahoma State roster and highlight what they did in recruiting and the transfer portal this offseason. How will the Cowboys bounce back after the postseason ban in 2022-2023? OUTGOING 6'2 G Bryce Williams (Graduated – 8 pts, 3 ast, 2 reb) 6'5 G Isaac Likekele (Trasnferred to Ohio St – 7 pts, 6 reb, 3 ast) 6'5 G Rondel Walker (Transferred to TCU – 5 pts, 3 reb) 6'8 F Keylan Boone (Transferred to Pacific – 6 pts, 3 reb) 6'7 F Matthew-Alexander Moncrieffe (Transferred to Georgia – 4 pts, 4 reb) INCOMING 6'3 G Caleb Asberry (Transfer from Texas St – 14 pts, 5 reb, 2 ast) 6'7 F Russell Harrison (Transfer from UL Monroe – 13 pts, 6 reb) 6'0 G John-Michael Wright (Transfer from High Point – 18 pts, 4 reb, 3 ast) 6'4 F Quion Williams (Ranked #103 from Jonesboro, AK) Projected Roster Starting 5 1 – 6'1 SR. John-Michael Wright (Transfer from High Point – 18 pts, 4 reb, 3 ast) 2 – 6'3 SR. Avery Anderson (12 pts, 3 reb, 2 stl) 3 – 6'6 JR. Bryce Thompson (11 pts, 2 reb) 4 – 6'9 SR. Kalib Boone (6 pts, 3 reb) 5 – 7'1 JR. Moussa Cisse (7 pts, 6 reb, 2 blk) Preseason Tournament Baha Mar Hoops Bahamas Championship (November 18th & 20th in the Bahamas) Open with UCF. The other semifinal matchup is between DePaul & Santa Clara. Rest of the Non-Conference Schedule: November 7th – UT Arlington November 10th – Southern Illinois November 13th – at Oakland November 25th – Tulsa November 27th - Prairie View A&M December 1st – at UConn (Big 12 / Big East Challenge) December 6th – Sam Houston December 11th - vs Virginia Tech (Hall of Fame Invitational in Brooklyn, NY) December 17th - at Wichita State December 20th – Texas A&M CC January 28th – Ole Miss (Big 12 / SEC Challenge) SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPN Sign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Oklahoma State Cowboys Basketball Season Preview 2022-2023 (Ep. 191)

Play Episode Listen Later Oct 14, 2022 38:35

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Oklahoma State Cowboys. Pick Dundee aka (@TheColbyD) and Ryan McIntyre (@Moneyline_Mac) break down the Oklahoma State roster and highlight what they did in recruiting and the transfer portal this offseason. How will the Cowboys bounce back after the postseason ban in 2022-2023?OUTGOING 6'2 G Bryce Williams (Graduated – 8 pts, 3 ast, 2 reb) 6'5 G Isaac Likekele (Trasnferred to Ohio St – 7 pts, 6 reb, 3 ast) 6'5 G Rondel Walker (Transferred to TCU – 5 pts, 3 reb) 6'8 F Keylan Boone (Transferred to Pacific – 6 pts, 3 reb) 6'7 F Matthew-Alexander Moncrieffe (Transferred to Georgia – 4 pts, 4 reb) INCOMING 6'3 G Caleb Asberry (Transfer from Texas St – 14 pts, 5 reb, 2 ast) 6'7 F Russell Harrison (Transfer from UL Monroe – 13 pts, 6 reb) 6'0 G John-Michael Wright (Transfer from High Point – 18 pts, 4 reb, 3 ast) 6'4 F Quion Williams (Ranked #103 from Jonesboro, AK) Projected RosterStarting 51 – 6'1 SR. John-Michael Wright (Transfer from High Point – 18 pts, 4 reb, 3 ast)2 – 6'3 SR. Avery Anderson (12 pts, 3 reb, 2 stl)3 – 6'6 JR. Bryce Thompson (11 pts, 2 reb)4 – 6'9 SR. Kalib Boone (6 pts, 3 reb)5 – 7'1 JR. Moussa Cisse (7 pts, 6 reb, 2 blk)Preseason TournamentBaha Mar Hoops Bahamas Championship (November 18th & 20th in the Bahamas)Open with UCF. The other semifinal matchup is between DePaul & Santa Clara.Rest of the Non-Conference Schedule:November 7th – UT ArlingtonNovember 10th – Southern IllinoisNovember 13th – at OaklandNovember 25th – TulsaNovember 27th - Prairie View A&MDecember 1st – at UConn (Big 12 / Big East Challenge)December 6th – Sam HoustonDecember 11th - vs Virginia Tech (Hall of Fame Invitational in Brooklyn, NY)December 17th - at Wichita StateDecember 20th – Texas A&M CCJanuary 28th – Ole Miss (Big 12 / SEC Challenge)SGPN Merch Store - https://sg.pn/storeDownload The Free SGPN App - https://sgpn.appWynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBETSupport for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPNSign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social MediaTwitter - https://twitter.com/TCEonSGPNTwitter - http://www.twitter.com/gamblingpodcastInstagram - http://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social MediaColby Dant - http://www.twitter.com/thecolbydPatty C - https://twitter.com/PattyC831NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling PodcastYouTube - https://www.sg.pn/YouTubeTwitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversationWebsite - https://www.sportsgamblingpodcast.comDiscord - https://sg.pn/discordReddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Oklahoma State Cowboys Basketball Season Preview 2022-2023 (Ep. 191)

Play Episode Listen Later Oct 14, 2022 39:20

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Oklahoma State Cowboys. Pick Dundee aka (@TheColbyD) and Ryan McIntyre (@Moneyline_Mac) break down the Oklahoma State roster and highlight what they did in recruiting and the transfer portal this offseason. How will the Cowboys bounce back after the postseason ban in 2022-2023? OUTGOING 6'2 G Bryce Williams (Graduated – 8 pts, 3 ast, 2 reb) 6'5 G Isaac Likekele (Trasnferred to Ohio St – 7 pts, 6 reb, 3 ast) 6'5 G Rondel Walker (Transferred to TCU – 5 pts, 3 reb) 6'8 F Keylan Boone (Transferred to Pacific – 6 pts, 3 reb) 6'7 F Matthew-Alexander Moncrieffe (Transferred to Georgia – 4 pts, 4 reb) INCOMING 6'3 G Caleb Asberry (Transfer from Texas St – 14 pts, 5 reb, 2 ast) 6'7 F Russell Harrison (Transfer from UL Monroe – 13 pts, 6 reb) 6'0 G John-Michael Wright (Transfer from High Point – 18 pts, 4 reb, 3 ast) 6'4 F Quion Williams (Ranked #103 from Jonesboro, AK) Projected Roster Starting 5 1 – 6'1 SR. John-Michael Wright (Transfer from High Point – 18 pts, 4 reb, 3 ast) 2 – 6'3 SR. Avery Anderson (12 pts, 3 reb, 2 stl) 3 – 6'6 JR. Bryce Thompson (11 pts, 2 reb) 4 – 6'9 SR. Kalib Boone (6 pts, 3 reb) 5 – 7'1 JR. Moussa Cisse (7 pts, 6 reb, 2 blk) Preseason Tournament Baha Mar Hoops Bahamas Championship (November 18th & 20th in the Bahamas) Open with UCF. The other semifinal matchup is between DePaul & Santa Clara. Rest of the Non-Conference Schedule: November 7th – UT Arlington November 10th – Southern Illinois November 13th – at Oakland November 25th – Tulsa November 27th - Prairie View A&M December 1st – at UConn (Big 12 / Big East Challenge) December 6th – Sam Houston December 11th - vs Virginia Tech (Hall of Fame Invitational in Brooklyn, NY) December 17th - at Wichita State December 20th – Texas A&M CC January 28th – Ole Miss (Big 12 / SEC Challenge) SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPN Sign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Duke Blue Devils Basketball Season Preview 2022-2023 | The College Basketball Experience (Ep. 184)

Play Episode Listen Later Sep 28, 2022 44:34

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Duke Blue Devils. Pick Dundee aka (@TheColbyD) and NC Nick (@NC_NicK) break down the Duke roster and highlight what they did in recruiting and the transfer portal this offseason. What will the Blue Devils look like in Year #1 under Jon Scheyer? Offseason Changes OUTGOING Mike Krzyzewski 6'10 F Paolo Banchero (Orlando Magic – 17 pts, 8 reb) 6'5 F Wendell Moore Jr. (Minnesota Timberwolves – 13 pts, 5 reb) 6'4 G Trevor Keels (New York Knicks – 12 pts, 3 reb) 7'0 C Mark Williams (Charlotte Hornets – 11 pts, 3 blk) 6'6 F AJ Griffin (Atlanta Hawks – 10 pts, 45% 3pt) 6'6 F Joey Baker (Transferred to Michigan – 4 pts) INCOMING 6'6 G Jacob Grandison (Transfer from Illinois – 9 pts, 4 rebs) 6'10 Ryan Young (Transfer from Northwestern – 9 pts, 4 rebs) 6'6 F Kale Catchings (Transfer from Harvard – 9 pts, 4 rebs) 7'1 C Dereck Lively (Ranked #1 from Norristown, PA) 6'6 F Dariq Whitehead (Ranked #2 from Montverde, FL) 6'11 C Kyle Filipowski (Ranked #4 from Wilbraham, MA) 6'8 F Mark Mitchell (Ranked #22 from Wichita, KS) 6'5 G Jaden Schutt (Ranked #68 from Yorkville, IL) 7'1 C Christian Reeves (Ranked #139 from Mouth of Wilson, VA) Projected Roster Starting 5 1 – 6'2 JR. Jeremy Roach (8 pts, 3 ast) 2 – 6'6 GR. Jacob Grandison (Transfer from Illinois – 9 pts, 4 rebs) 3 – 6'6 FR. Dariq Whitehead 4 – 6'11 FR. Kyle Filipowski 5 – 7'1 FR. Dereck Lively Preseason Tournament Phil Knight Invitational (November 24-27 in Portland, OR) Open with Oregon St. The rest of the field includes Florida, Gonzaga, Portland St, Purdue, West Virginia, & Xavier. Rest of the Non-Conference Schedule: November 7th – Jacksonville November 11th – USC Upstate November 15th – vs Kansas (Champions Classic in Indianapolis) November 18th – Delaware November 21st - Bellarmine December 30th – Ohio St (ACC / Big Ten Challenge) December 6th – vs Iowa (New York, NY) December 10th – Maryland Eastern Shore SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Use code SGPNVIP at http://runyourpool.com/vip and get 50% off of your first month Join Sleeper and get a 100% deposit bonus up to $100 - https://sleeper.com/sgp PROMOGUY.US - HUGE $ Bonuses and +EV Betting Community Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPN Sign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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North Carolina Tar Heels Basketball Season Preview 2022-2023 | The College Basketball Experience (Ep. 185)

Play Episode Listen Later Sep 28, 2022 46:09

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the North Carolina Tar Heels. Pick Dundee aka (@TheColbyD), NC Nick (@NC_NicK), and Terrell Furman (@reallyrell_) break down the North Carolina roster and highlight what they did in recruiting and the transfer portal this offseason. Can Hubert Davis get the Tar Heels back to the Final Four and cut down the nets in 2022-2023? Offseason Changes OUTGOING 6'9 F Brady Manek (Graduated – 15 pts, 6 reb) 6'11 F Dawson Garcia (Transferred to Minnesota – 9 pts, 6 reb) 6'5 G Kerwin Walton (Transferred to Texas Tech – 3 pts, 35% 3pt) 6'4 G Anthony Harris (Transferred to Rhode Island – 3 pts) INCOMING 6'10 F Pete Nance (Transfer from Northwestern – 15 pts, 7 reb, 45% 3pt) 6'3 G Seth Trimble (Ranked #37 from Menomonee Falls, WI) 6'9 C Jalen Washington (Ranked #47 from Gary, IN) 6'8 F Tyler Nickel (Ranked #79 from Harrisonburg, VA) Projected Roster Starting 5 Starting 5 1 – 6'0 JR. RJ Davis (14 pts, 4 ast, 37% 3pt) 2 – 6'4 JR. Caleb Love (16 pts, 4 ast, 36% 3pt) 3 – 6'9 GR. Leaky Black (5 pts, 4 reb) 4 – 6'11 GR. Pete Nance (Transfer from Northwestern – 15 pts, 7 reb, 45% 3pt) 5 – 6'11 SR. Armando Bacot (16 pts, 13 reb, 2 blk) Preseason Tournament Phil Knight Invitational (November 24-27 in Portland, OR) Open with Portland. The rest of the field includes Alabama, Iowa St, Michigan St, Oregon, Connecticut, & Villanova. Rest of the Non-Conference Schedule: November 7th – UNC Wilmington November 11th – College of Charleston November 15th – Gardner Webb November 20th – James Madison December 30th – at Indiana (ACC / Big Ten Challenge) December 13th – The Citadel December 17th – vs Ohio St (CBS Sports Classic in New York, NY) December 21st – vs Michigan (Jumpman Invitational in Charlotte, NC) SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Use code SGPNVIP at http://runyourpool.com/vip and get 50% off of your first month Join Sleeper and get a 100% deposit bonus up to $100 - https://sleeper.com/sgp PROMOGUY.US - HUGE $ Bonuses and +EV Betting Community Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPN Sign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Duke Blue Devils Basketball Season Preview 2022-2023 (Ep. 184)

Play Episode Listen Later Sep 28, 2022 43:49

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Duke Blue Devils. Pick Dundee aka (@TheColbyD) and NC Nick (@NC_NicK) break down the Duke roster and highlight what they did in recruiting and the transfer portal this offseason. What will the Blue Devils look like in Year #1 under Jon Scheyer?Offseason ChangesOUTGOING Mike Krzyzewski 6'10 F Paolo Banchero (Orlando Magic – 17 pts, 8 reb) 6'5 F Wendell Moore Jr. (Minnesota Timberwolves – 13 pts, 5 reb) 6'4 G Trevor Keels (New York Knicks – 12 pts, 3 reb) 7'0 C Mark Williams (Charlotte Hornets – 11 pts, 3 blk) 6'6 F AJ Griffin (Atlanta Hawks – 10 pts, 45% 3pt) 6'6 F Joey Baker (Transferred to Michigan – 4 pts) INCOMING 6'6 G Jacob Grandison (Transfer from Illinois – 9 pts, 4 rebs) 6'10 Ryan Young (Transfer from Northwestern – 9 pts, 4 rebs) 6'6 F Kale Catchings (Transfer from Harvard – 9 pts, 4 rebs) 7'1 C Dereck Lively (Ranked #1 from Norristown, PA) 6'6 F Dariq Whitehead (Ranked #2 from Montverde, FL) 6'11 C Kyle Filipowski (Ranked #4 from Wilbraham, MA) 6'8 F Mark Mitchell (Ranked #22 from Wichita, KS) 6'5 G Jaden Schutt (Ranked #68 from Yorkville, IL) 7'1 C Christian Reeves (Ranked #139 from Mouth of Wilson, VA) Projected RosterStarting 51 – 6'2 JR. Jeremy Roach (8 pts, 3 ast)2 – 6'6 GR. Jacob Grandison (Transfer from Illinois – 9 pts, 4 rebs)3 – 6'6 FR. Dariq Whitehead4 – 6'11 FR. Kyle Filipowski5 – 7'1 FR. Dereck LivelyPreseason TournamentPhil Knight Invitational (November 24-27 in Portland, OR)Open with Oregon St. The rest of the field includes Florida, Gonzaga, Portland St, Purdue, West Virginia, & Xavier.Rest of the Non-Conference Schedule:November 7th – JacksonvilleNovember 11th – USC UpstateNovember 15th – vs Kansas (Champions Classic in Indianapolis)November 18th – DelawareNovember 21st - BellarmineDecember 30th – Ohio St (ACC / Big Ten Challenge)December 6th – vs Iowa (New York, NY)December 10th – Maryland Eastern ShoreSGPN Merch Store - https://sg.pn/storeDownload The Free SGPN App - https://sgpn.appWynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBETUse code SGPNVIP at http://runyourpool.com/vip and get 50% off of your first monthJoin Sleeper and get a 100% deposit bonus up to $100 - https://sleeper.com/sgpPROMOGUY.US - HUGE $ Bonuses and +EV Betting CommunitySupport for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPNSign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social MediaTwitter - https://twitter.com/TCEonSGPNTwitter - http://www.twitter.com/gamblingpodcastInstagram - http://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social MediaColby Dant - http://www.twitter.com/thecolbydPatty C - https://twitter.com/PattyC831NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling PodcastYouTube - https://www.sg.pn/YouTubeTwitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversationWebsite - https://www.sportsgamblingpodcast.comDiscord - https://sg.pn/discordReddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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North Carolina Tar Heels Basketball Season Preview 2022-2023 (Ep. 185)

Play Episode Listen Later Sep 28, 2022 45:24

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the North Carolina Tar Heels. Pick Dundee aka (@TheColbyD), NC Nick (@NC_NicK), and Terrell Furman (@reallyrell_) break down the North Carolina roster and highlight what they did in recruiting and the transfer portal this offseason. Can Hubert Davis get the Tar Heels back to the Final Four and cut down the nets in 2022-2023?Offseason ChangesOUTGOING 6'9 F Brady Manek (Graduated – 15 pts, 6 reb) 6'11 F Dawson Garcia (Transferred to Minnesota – 9 pts, 6 reb) 6'5 G Kerwin Walton (Transferred to Texas Tech – 3 pts, 35% 3pt) 6'4 G Anthony Harris (Transferred to Rhode Island – 3 pts) INCOMING 6'10 F Pete Nance (Transfer from Northwestern – 15 pts, 7 reb, 45% 3pt) 6'3 G Seth Trimble (Ranked #37 from Menomonee Falls, WI) 6'9 C Jalen Washington (Ranked #47 from Gary, IN) 6'8 F Tyler Nickel (Ranked #79 from Harrisonburg, VA) Projected RosterStarting 5Starting 51 – 6'0 JR. RJ Davis (14 pts, 4 ast, 37% 3pt)2 – 6'4 JR. Caleb Love (16 pts, 4 ast, 36% 3pt)3 – 6'9 GR. Leaky Black (5 pts, 4 reb)4 – 6'11 GR. Pete Nance (Transfer from Northwestern – 15 pts, 7 reb, 45% 3pt)5 – 6'11 SR. Armando Bacot (16 pts, 13 reb, 2 blk)Preseason TournamentPhil Knight Invitational (November 24-27 in Portland, OR)Open with Portland. The rest of the field includes Alabama, Iowa St, Michigan St, Oregon, Connecticut, & Villanova.Rest of the Non-Conference Schedule:November 7th – UNC WilmingtonNovember 11th – College of CharlestonNovember 15th – Gardner WebbNovember 20th – James MadisonDecember 30th – at Indiana (ACC / Big Ten Challenge)December 13th – The CitadelDecember 17th – vs Ohio St (CBS Sports Classic in New York, NY)December 21st – vs Michigan (Jumpman Invitational in Charlotte, NC)SGPN Merch Store - https://sg.pn/storeDownload The Free SGPN App - https://sgpn.appWynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBETUse code SGPNVIP at http://runyourpool.com/vip and get 50% off of your first monthJoin Sleeper and get a 100% deposit bonus up to $100 - https://sleeper.com/sgpPROMOGUY.US - HUGE $ Bonuses and +EV Betting CommunitySupport for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPNSign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social MediaTwitter - https://twitter.com/TCEonSGPNTwitter - http://www.twitter.com/gamblingpodcastInstagram - http://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social MediaColby Dant - http://www.twitter.com/thecolbydPatty C - https://twitter.com/PattyC831NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling PodcastYouTube - https://www.sg.pn/YouTubeTwitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversationWebsite - https://www.sportsgamblingpodcast.comDiscord - https://sg.pn/discordReddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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North Carolina Tar Heels Basketball Season Preview 2022-2023 (Ep. 185)

Play Episode Listen Later Sep 28, 2022 46:09

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the North Carolina Tar Heels. Pick Dundee aka (@TheColbyD), NC Nick (@NC_NicK), and Terrell Furman (@reallyrell_) break down the North Carolina roster and highlight what they did in recruiting and the transfer portal this offseason. Can Hubert Davis get the Tar Heels back to the Final Four and cut down the nets in 2022-2023? Offseason Changes OUTGOING 6'9 F Brady Manek (Graduated – 15 pts, 6 reb) 6'11 F Dawson Garcia (Transferred to Minnesota – 9 pts, 6 reb) 6'5 G Kerwin Walton (Transferred to Texas Tech – 3 pts, 35% 3pt) 6'4 G Anthony Harris (Transferred to Rhode Island – 3 pts) INCOMING 6'10 F Pete Nance (Transfer from Northwestern – 15 pts, 7 reb, 45% 3pt) 6'3 G Seth Trimble (Ranked #37 from Menomonee Falls, WI) 6'9 C Jalen Washington (Ranked #47 from Gary, IN) 6'8 F Tyler Nickel (Ranked #79 from Harrisonburg, VA) Projected Roster Starting 5 Starting 5 1 – 6'0 JR. RJ Davis (14 pts, 4 ast, 37% 3pt) 2 – 6'4 JR. Caleb Love (16 pts, 4 ast, 36% 3pt) 3 – 6'9 GR. Leaky Black (5 pts, 4 reb) 4 – 6'11 GR. Pete Nance (Transfer from Northwestern – 15 pts, 7 reb, 45% 3pt) 5 – 6'11 SR. Armando Bacot (16 pts, 13 reb, 2 blk) Preseason Tournament Phil Knight Invitational (November 24-27 in Portland, OR) Open with Portland. The rest of the field includes Alabama, Iowa St, Michigan St, Oregon, Connecticut, & Villanova. Rest of the Non-Conference Schedule: November 7th – UNC Wilmington November 11th – College of Charleston November 15th – Gardner Webb November 20th – James Madison December 30th – at Indiana (ACC / Big Ten Challenge) December 13th – The Citadel December 17th – vs Ohio St (CBS Sports Classic in New York, NY) December 21st – vs Michigan (Jumpman Invitational in Charlotte, NC) SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Use code SGPNVIP at http://runyourpool.com/vip and get 50% off of your first month Join Sleeper and get a 100% deposit bonus up to $100 - https://sleeper.com/sgp PROMOGUY.US - HUGE $ Bonuses and +EV Betting Community Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPN Sign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Duke Blue Devils Basketball Season Preview 2022-2023 (Ep. 184)

Play Episode Listen Later Sep 28, 2022 44:34

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Duke Blue Devils. Pick Dundee aka (@TheColbyD) and NC Nick (@NC_NicK) break down the Duke roster and highlight what they did in recruiting and the transfer portal this offseason. What will the Blue Devils look like in Year #1 under Jon Scheyer? Offseason Changes OUTGOING Mike Krzyzewski 6'10 F Paolo Banchero (Orlando Magic – 17 pts, 8 reb) 6'5 F Wendell Moore Jr. (Minnesota Timberwolves – 13 pts, 5 reb) 6'4 G Trevor Keels (New York Knicks – 12 pts, 3 reb) 7'0 C Mark Williams (Charlotte Hornets – 11 pts, 3 blk) 6'6 F AJ Griffin (Atlanta Hawks – 10 pts, 45% 3pt) 6'6 F Joey Baker (Transferred to Michigan – 4 pts) INCOMING 6'6 G Jacob Grandison (Transfer from Illinois – 9 pts, 4 rebs) 6'10 Ryan Young (Transfer from Northwestern – 9 pts, 4 rebs) 6'6 F Kale Catchings (Transfer from Harvard – 9 pts, 4 rebs) 7'1 C Dereck Lively (Ranked #1 from Norristown, PA) 6'6 F Dariq Whitehead (Ranked #2 from Montverde, FL) 6'11 C Kyle Filipowski (Ranked #4 from Wilbraham, MA) 6'8 F Mark Mitchell (Ranked #22 from Wichita, KS) 6'5 G Jaden Schutt (Ranked #68 from Yorkville, IL) 7'1 C Christian Reeves (Ranked #139 from Mouth of Wilson, VA) Projected Roster Starting 5 1 – 6'2 JR. Jeremy Roach (8 pts, 3 ast) 2 – 6'6 GR. Jacob Grandison (Transfer from Illinois – 9 pts, 4 rebs) 3 – 6'6 FR. Dariq Whitehead 4 – 6'11 FR. Kyle Filipowski 5 – 7'1 FR. Dereck Lively Preseason Tournament Phil Knight Invitational (November 24-27 in Portland, OR) Open with Oregon St. The rest of the field includes Florida, Gonzaga, Portland St, Purdue, West Virginia, & Xavier. Rest of the Non-Conference Schedule: November 7th – Jacksonville November 11th – USC Upstate November 15th – vs Kansas (Champions Classic in Indianapolis) November 18th – Delaware November 21st - Bellarmine December 30th – Ohio St (ACC / Big Ten Challenge) December 6th – vs Iowa (New York, NY) December 10th – Maryland Eastern Shore SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Use code SGPNVIP at http://runyourpool.com/vip and get 50% off of your first month Join Sleeper and get a 100% deposit bonus up to $100 - https://sleeper.com/sgp PROMOGUY.US - HUGE $ Bonuses and +EV Betting Community Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPN Sign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Virginia Tech Hokies Basketball Season Preview 2022-2023 | The College Basketball Experience (Ep. 183)

Play Episode Listen Later Sep 22, 2022 40:59

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Virginia Tech Hokies. Pick Dundee aka (@TheColbyD) and Ryan McIntyre (@Moneyline_Mac) break down the Virginia Tech roster and highlight what they did in recruiting and the transfer portal this offseason. Can Mike Young make it three straight NCAA Tournaments in Blacksburg? Offseason Changes OUTGOING 6'9 F Keve Aluma (Graduated – 10 pts, 6 reb) 6'4 G Nahiem Alleyne (Transferred to UConn – 10 pts, 3 reb) 6'0 G Storm Murphy (Graduated – 8 pts, 36% 3pt) 6'9 F David N'Guessan (Transferred to Kansas St – 4 pts, 3 reb) 6'10 C John Ojiako (Transferred to George Mason – 2 pts, 2 reb) INCOMING 6'9 F Grant Basile (Transfer from Wright St – 18 pts, 9 reb) 6'7 F John Camden (Transfer from Memphis) 6'8 F Mylyjael Poteat (Transfer from Rice – 8 pts, 4 reb) 6'4 G Rodney Rice (Ranked #67 from Clinton, MD) 7'0 C Patrick Wessler (Ranked #150 from Charlotte, NC) 6'4 G Michael Collins (Ranked #182 from Clover, SC) 6'7 F Darren Buchanan (Not Ranked from Washington, DC) Projected Roster Starting 5 Starting 5 1 – 6'1 SO. Sean Pedulla (5 pts) 2 – 6'3 SR. Hunter Cattoor (10 pts, 42% 3pt) 3 – 6'5 JR. Darius Maddox (6 pts, 50% 3pt) 4 – 6'7 GR. Justyn Mutts (10 pts, 7 reb) 5 – 6'9 GR. Grant Basile (Transfer from Wright St – 18 pts, 9 reb) Preseason Tournament Charleston Classic (November 17-20 in Charleston, SC) Open with Old Dominion. The rest of the field includes College of Charleston, Colorado St, Davidson, Furman, Penn St, & South Carolina. Rest of the Non-Conference Schedule: November 7th – Delaware St November 10th – Lehigh November 13th – William & Mary November 25th – Charleston Southern December 28th – Minnesota (ACC / Big Ten Challenge) December 7th – Dayton December 11th - vs Oklahoma St (Brooklyn, NY) December 17th – Grambling St SGPN Merch Store - https://sg.pn/store Download The Free SGPN App - https://sgpn.app WynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBET Use code SGPNVIP at http://runyourpool.com/vip and get 50% off of your first month Join Sleeper and get a 100% deposit bonus up to $100 - https://sleeper.com/sgp PROMOGUY.US - HUGE $ Bonuses and +EV Betting Community Support for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPN Sign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social Media Twitter - https://twitter.com/TCEonSGPN Twitter - http://www.twitter.com/gamblingpodcast Instagram - http://www.instagram.com/sportsgamblingpodcast TikTok - https://www.tiktok.com/@gamblingpodcast Facebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social Media Colby Dant - http://www.twitter.com/thecolbyd Patty C - https://twitter.com/PattyC831 NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling Podcast YouTube - https://www.sg.pn/YouTube Twitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversation Website - https://www.sportsgamblingpodcast.com Discord - https://sg.pn/discord Reddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Virginia Tech Hokies Basketball Season Preview 2022-2023 (Ep. 183)

Play Episode Listen Later Sep 22, 2022 40:14

The College Basketball Experience (@TCEonSGPN) on the Sports Gambling Podcast Network previews the upcoming basketball season for the Virginia Tech Hokies. Pick Dundee aka (@TheColbyD) and Ryan McIntyre (@Moneyline_Mac) break down the Virginia Tech roster and highlight what they did in recruiting and the transfer portal this offseason. Can Mike Young make it three straight NCAA Tournaments in Blacksburg? Offseason ChangesOUTGOING 6'9 F Keve Aluma (Graduated – 10 pts, 6 reb) 6'4 G Nahiem Alleyne (Transferred to UConn – 10 pts, 3 reb) 6'0 G Storm Murphy (Graduated – 8 pts, 36% 3pt) 6'9 F David N'Guessan (Transferred to Kansas St – 4 pts, 3 reb) 6'10 C John Ojiako (Transferred to George Mason – 2 pts, 2 reb) INCOMING 6'9 F Grant Basile (Transfer from Wright St – 18 pts, 9 reb) 6'7 F John Camden (Transfer from Memphis) 6'8 F Mylyjael Poteat (Transfer from Rice – 8 pts, 4 reb) 6'4 G Rodney Rice (Ranked #67 from Clinton, MD) 7'0 C Patrick Wessler (Ranked #150 from Charlotte, NC) 6'4 G Michael Collins (Ranked #182 from Clover, SC) 6'7 F Darren Buchanan (Not Ranked from Washington, DC) Projected RosterStarting 5Starting 51 – 6'1 SO. Sean Pedulla (5 pts)2 – 6'3 SR. Hunter Cattoor (10 pts, 42% 3pt)3 – 6'5 JR. Darius Maddox (6 pts, 50% 3pt)4 – 6'7 GR. Justyn Mutts (10 pts, 7 reb)5 – 6'9 GR. Grant Basile (Transfer from Wright St – 18 pts, 9 reb)Preseason TournamentCharleston Classic (November 17-20 in Charleston, SC)Open with Old Dominion. The rest of the field includes College of Charleston, Colorado St, Davidson, Furman, Penn St, & South Carolina.Rest of the Non-Conference Schedule:November 7th – Delaware StNovember 10th – LehighNovember 13th – William & MaryNovember 25th – Charleston SouthernDecember 28th – Minnesota (ACC / Big Ten Challenge)December 7th – DaytonDecember 11th - vs Oklahoma St (Brooklyn, NY)December 17th – Grambling StSGPN Merch Store - https://sg.pn/storeDownload The Free SGPN App - https://sgpn.appWynnBET - Bet $100 and get a $100 FREE bet! - https://sg.pn/WynnBETUse code SGPNVIP at http://runyourpool.com/vip and get 50% off of your first monthJoin Sleeper and get a 100% deposit bonus up to $100 - https://sleeper.com/sgpPROMOGUY.US - HUGE $ Bonuses and +EV Betting CommunitySupport for this episode - OddsTrader.com/bluewire | Fubo.tv/sgp Find Elias Game Plan Sports Betting in the App Store or Play Store today and use my promo code SGPNSign up now with promocode: SGPN at nohouseadvantage.com or download the app on the app stores to get a 1st deposit match up to $25! Follow The College Experience & SGPN On Social MediaTwitter - https://twitter.com/TCEonSGPNTwitter - http://www.twitter.com/gamblingpodcastInstagram - http://www.instagram.com/sportsgamblingpodcastTikTok - https://www.tiktok.com/@gamblingpodcastFacebook - http://www.facebook.com/sportsgamblingpodcast Follow The Hosts On Social MediaColby Dant - http://www.twitter.com/thecolbydPatty C - https://twitter.com/PattyC831NC Nick - https://twitter.com/NC__NicK Watch the Sports Gambling PodcastYouTube - https://www.sg.pn/YouTubeTwitch - https://www.sg.pn/Twitch Read & Discuss - Join the conversationWebsite - https://www.sportsgamblingpodcast.comDiscord - https://sg.pn/discordReddit - https://www.sg.pn/reddit Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Virginia Tech Hokies Basketball Season Preview 2022-2023 (Ep. 183)