Podcasts about resistant

In this foundational January episode, Dr. Scott Watier and Tommy Welling put insulin at the forefront of 2026 by unpacking five surprising metabolic insights from Dr. Ben Bikman, the world's leading insulin researcher, revealing why standard blood work misses early insulin resistance for years before glucose finally rises. They expose the hidden metabolic crisis where normal labs mask the slow march of insulin resistance that begins in overfilled fat cells—which become insulin resistant first as a protective mechanism to prevent rupture—then cascades to the liver, muscle, endothelium, and brain, explaining why seemingly unrelated conditions like PCOS, erectile dysfunction, brain fog, and cardiovascular disease all stem from the same insulin dysfunction. The hosts debunk the saturated fat myth by revealing that most saturated fat in your bloodstream comes from your liver converting excess carbohydrates through de novo lipogenesis, not from butter or steak, making late-night carbs particularly devastating since insulin sensitivity drops 30% at night, sabotaging sleep and activating fight-or-flight responses. This episode delivers the science-backed framework for why fasting isn't about restriction but about asking less of your insulin so cells can finally hear the signal to burn fat, providing actionable strategies including earlier meal timing, resistance training for glucose utilization, and specific lab markers like fasting insulin and HOMA-IR that flag metabolic dysfunction long before standard tests catch it. ⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Relevant Links: https://www.youtube.com/watch?v=2PROANAQkwA

This week on RulaskaThoughts, Joe and Robert unpack RuPaul's Drag Race Season 18, Episode 3 — an installment that inspires far more commentary about the state of the franchise than about the challenge itself. Along the way, they detour through internet discourse, celebrity behavior, and why Drag Race increasingly feels like a legacy show coasting on goodwill rather than innovation. Joe opens by apologizing — not for the episode, but for how little the episode itself deserves attention. Both agree RDR Live wasn't actively painful, but also wasn't good — merely another in a long line of mediocre acting challenges. Juicy Love Dion wins for fully disappearing into character, even if she wasn't the funniest. Athena Love Dion's hosting performance sparks disagreement: Joe finds it serviceable and thankless, while Robert reads visible nervousness and lack of authority. Mandy Mango's critiques reignite the recurring Drag Race issue: queens being punished for doing exactly what's written in the script. The lip-sync song choice is widely panned as fundamentally ill-suited for a “lip-sync for your life,” regardless of who technically won. Joe lays out what he sees as a pattern of soft bullying toward Athena across multiple episodes. Evidence cited: Repeated exclusion from team selection Roles being denied without discussion or competition Other queens weaponizing “you should want this” logic against her Age-based digs becoming an easy, recurring punchline Joe questions why Athena is treated as the default host when other queens (notably Jane Doe) have equivalent hosting credentials. Briar Blush is positioned as a key instigator, particularly in steering Athena toward roles designed to undermine her. Robert counters that Athena may unintentionally fuel the dynamic through visible frustration and exaggerated reactions, making herself an easy target. Both acknowledge the possibility that off-camera behavior may be influencing how the cast responds — but stress that the edit has not justified the treatment so far. Joe argues the problem is not the cast, but entrenched production leadership. Drag Race is compared to Saturday Night Live: Long-running, culturally important Run by aging leadership increasingly out of sync with audience taste Resistant to structural change Discussion of why Drag Race scripts remain weak despite access to: UCB Groundlings Queer comedy writers who could elevate the material with minimal investment The absence of meme culture is flagged as a major warning sign — Drag Race no longer drives online conversation the way it once did. Alaska's recent comments about drag queens no longer releasing music are cited as another indicator that the franchise has lost its grip on the “gay dollar.” Joe dismantles the argument that Drag Race is “too hard to find,” noting it has always lived on basic cable. The real issue, both agree, is diminishing reward — viewers don't feel like they're missing a cultural moment anymore. Unlike earlier eras, skipping an episode now carries no social consequence. Next week's runway mash-up challenge is previewed with skepticism — familiar concepts repackaged yet again. The upcoming talent show inspires preemptive dread over self-serious spoken-word tracks and faux-quirky personas. Joe predicts certain queens are currently protected by “filler eliminations” — but their time is coming. This episode of RulaskaThoughts becomes less about RDR Live and more about Drag Race's identity crisis: a once-vital franchise struggling under the weight of its own longevity. While Joe and Robert still clearly care — and still watch — the conversation makes clear that love has shifted from excitement to obligation, and from celebration to critique. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The crew of the Little Snail has come to Spillaway Peaks in search of an ally: Thelonious, the editor-in-chief of the Shining Star newspaper and a member of the mysterious group called the Luminaries. But before they can go, meet Theo, and earn his trust, they first have to do a little shopping… This week on Perpetua: A Picture of the HIlls 02 Perpetua Guide [In Progress v.058] Town Maps [TNMP] Spillaway Peaks [SPMP] The Shell Barrow You know that big dome you can see at Spillaway Peaks from the world map? Yeah, this is it. This is where they do their "Weekly Rehearsal," which is like Church Sunday for them. Depending on how things go, you can visit this place at the end of the arc and get a buff.  The Clutch This is where Terrapine kids grow up and go to school. You can get a pretty good Jonathan scene if you go here, but that's about it for now. The Docks and Administrative District There's not much here, except a way to get back on the Ferry and head back to Calstega Bay Jonathan's Family Home This is the only of the Clan Homes you can actually enter, but it's pretty big! It's four or five levels high (depending on how you count) and there are a ton of rooms to explore, random NPCs to talk to, and some loot too! If you do a side quest for Jonathan's dad, he can build you some gear in his workshop! The Shining Star The town newspaper. If you're ready to advance the main plot, head up to the second floor of the Shining Star. You'll automatically run into Theolonius (and Jonathan's sister is working there as an intern or something, too). But if you aren't ready yet, you can stay downstairs and use the quest board to grind out some XP and asta! Shopping District The highest level of the Spillaway City map (not counting the Spillaway Outskirts, but there you have to load out to the world map before getting there, so I don't count it!) There are three main shops here. A general store, which basically just lets you recover IP and get basic items, and then Abelene's Armory and Stokely's Specialties. Abelene's Armory Armor: Reinforced Mud Suit 300 asta | 11 Phys Def / INS size +1 Mdef | -5 Init | Earth Resistant  Armor: Meditation Robe 1000 asta | Def: DEX die +1 / MDEF: INS die +2 |-2 Init Whenever you recover Mind Points, you recover 5 extra Mind Points. Armor: Choir Robe 1000 asta |  Def: DEX size +1 / Mdef: INS size +2 |-2 Init Counts as 1 bonus SL of "Sound Barrier": After you sing a verse with medium or high volume, all physical damage you suffer until the start of your next turn is reduced by【SL】(applied before Affinities). Shield: Eyecatching Cape 800 z | +2 Def /+0 Mdef As long as you don't have a martial armor or another shield equipped, you may apply the effects of the Dodge Skill (see Core Rulebook, page 203).  Shield: Seasoned Potlid 1500 asta | Martial |+2 Def /+2 MDef  When you deal damage with a delicacy (see page 151), you deal 5 extra damage. Shield: Plated Tambourine 1700 asta | +2 Def / +0 Mdef If you have the Resonance Skill , consider your Skill Level in it increased by 2 (up to a maximum of SL 5). Weapon: Giant Fork 1000 asta | DEX + MIG | HR + 16 | Martial | Physical Damage | Spear | Two-handed | Melee |  When you use this weapon with the Knife and Fork Skill, you may add the High Roll to the attack's damage  (you don't have to treat it as being equal to 0). Weapon: Electrified Flyswatter 1300 asta | MIG + DEX | HR+10 | Bolt Damage | One-handed | Melee You may attack Flying creatures, but you take -3 to the roll. Stokely's Specialties Accessory: Ring of the Occultist - 600 asta Spells you cast with a target of "Up to three creatures" instead have a target  of "Up to four creatures" (you must still spend additional Mind Points for the fourth target). Accessory: Spare Magicannon Chamber - 800 When you summon a Magicannon, you also receive an extra Elemental Chamber, matching the previous elemental type you stored.  Accessory: Ring of Denial 600 asta When you cast the Dispel spell (Core Rulebook, page 192), its MP cost becomes "10 × T" and its target becomes "Up to three creatures". Accessory: Lightcatcher Cage - 800 asta You are Resistant to bolt and light damage. If you enter Crisis, the effect of this accessory ceases until your next rest. Accessory: Ancient Pocketwatch - 600 Asta When using the Entropist skill Stolen Time, you may use any of its options one additional time per skill use (paying requisite MP cost as normal). Hosted by Austin Walker (austinwalker.bsky.social) Featuring Ali Acampora (ali-online.bsky.social), Art Martinez-Tebbel (amtebbel.bsky.social), Jack de Quidt (notquitereal.bsky.social), and Andrew Lee Swan (swandre3000.bsky.social) Produced by Ali Acampora Music by Jack de Quidt (available on bandcamp) Cover Art by Ben McEntee (https://linktr.ee/benmce.art) With thanks to Amelia Renee, Arthur B., Aster Maragos, Bill Kaszubski, Cassie Jones, Clark, DB, Daniel Laloggia, Diana Crowley, Edwin Adelsberger, Emrys, Greg Cobb, Ian O'Dea, Ian Urbina, Irina A., Jack Shirai, Jake Strang, Katie Diekhaus, Ken George, Konisforce, Kristina Harris Esq, L Tantivy, Lawson Coleman, Mark Conner, Mike & Ruby, Muna A, Nat Knight, Olive Perry, Quinn Pollock, Robert Lasica, Shawn Drape, Shawn Hall, Summer Rose, TeganEden, Thomas Whitney, Voi, chocoube, deepFlaw, fen, & weakmint This episode was made with support from listeners like you! To support us, you can go to friendsatthetable.cash.  

WATCH THIS ON YOUTUBEClinical supervision can go wrong fast when systems, boundaries, and communication are missing.In this podcast, I break down real-world examples of clinical supervision gone wrong, including court subpoenas, HIPAA violations, resistant interns, and supervision sites doing the bare minimum. This is a must-listen for licensed therapists, clinical supervisors, and practice owners who want to protect their license, avoid legal risk, and set clear expectations with supervisees.PRIVATE PRACTICE PLAYBOOKSUPERVISION KITABUNDANT THERAPIST PRIVATE PRACTICE BOOTCAMP - REGISTER NOWJOIN THE INHER COLLECTIVE

In episode #184 of Modern Persian Food, we explore two emerging trends that are reshaping home cooking: using AI to spark Persian recipe ideas and incorporating resistant starches for better gut health.   Bita Arabian shares how she's been turning to AI for quick menu inspiration—especially when trying to use up ingredients already in her fridge. From brainstorming Persian-inspired meals to reducing food waste and unlocking creative flavor pairings, she shows how technology can be a helpful (and fun!) kitchen sidekick.   Beata Nazem Kelley then highlights the growing conversation around resistant starches, explaining what they are, why they matter, and how Persian dishes naturally lend themselves to this gut-healthy approach. She offers simple examples of foods that increase resistant starch when cooked and cooled—like rice, potatoes, legumes, and whole grains—and suggests easy recipes and techniques to maximize their benefits.   If you enjoyed this episode, tell a friend! And we'd love to hear from you: How are you using AI to inspire your cooking? What resistant starch foods or Persian/Persian-inspired dishes are you trying at home?   Recipes: Ash Reshteh Persian Noodle, Bean, and Herb Soup - BeatsEats Persian Rice with Tahdig (Katte Recipe) – BeatsEats Persian Salad Olivieh – BeatsEats Persian Haleem Recipe (Oat & Chicken Porridge) | Nourishing & Satisfying – BeatsEats Maast o Khiar (Persian Cucumber and Yogurt Dip) – BeatsEats Maast-o Laboo – Persian Beet and Yogurt Dip – BeatsEats   Additional Resources: Coach Bita Wellness Coaching Consultation Call for Wellness Coaching - Schedule HERE   Persian Cooking Classes with Beata Nazem Kelley – BeatsEats Contact Beata@BeatsEats.com More info on Resistant Starches HERE:  https://beatseats.com/

Joshua Berman, MD, PhD, discusses how careful evaluation, patient priorities, and risk-benefit tradeoffs guide the use of interventional treatments when conventional approaches fall short. Dr. Berman also explains how tools such as ketamine, TMS, ECT, and neurofeedback can be used strategically—sometimes in sequence or combination—to address different vulnerabilities within mood-related brain circuits.Dr. Berman is Associate Professor of Psychiatry and Director of Interventional Psychiatry at NYU Langone Health.TopicsEvaluating patients who have not improved with medications or psychotherapyThe limitations of existing treatment guidelines for complex casesWhen and why sequencing or combining interventions may be appropriateEmerging approaches such as EEG-guided neurofeedback and focused ultrasoundBuilding a comprehensive, patient-centered interventional psychiatry programThis episode offers a clinician-level perspective on how interventional psychiatry is practiced today, and how new technologies may expand options for patients with the most challenging presentations.Chapters00:00 Introduction: Caring for Patients Who Don't Respond to Standard Treatment00:47 What Is Interventional Psychiatry?02:33 Evaluating Treatment-Resistant Presentations06:31 Precision, Patient Priorities, and Clinical Judgment09:35 Sequencing and Combining Interventions10:40 Limits of Treatment Guidelines12:18 The Future of Interventional Psychiatry13:23 Emerging Technologies: Neurofeedback and Focused Ultrasound17:15 Building a Comprehensive Interventional Program18:13 Tools vs. Understanding Brain CircuitsWatch Insights on Psychiatry on YouTubeExecutive Producer: Jon Earle

This podcast shows you how to fully recover from OCD.Each episode breaks down the exact techniques and nuances that stop rumination, reduce compulsions, and help you retrain your brain out of the OCD cycle. We cover every major OCD theme, including:Pure-O OCDRelationship OCDHarm OCDReal Event OCDSO-OCD / Sexuality OCDReligious / Scrupulosity OCDCleaning & Contamination OCDPhysical CompulsionsAll other OCD subtypesMy goal is simple: clear guidance that actually works, explained in a way that is calm, direct, and easy to apply immediately.You can fully recover from OCD. Don't give up — you're not stuck, and your brain can change.

Than from InspiringPhilosophy joined Pastor Nic to answer the questions that were asked during our Sunday services on December 14. They discuss topics relating to sharing the Gospel with unbelievers, tackle philosophical concepts, and give practical wisdom for those looking to level up their apologetics. Listen in to learn more! Visit the InspiringPhilosophy channel here: https://www.youtube.com/@UC5qDet6sa6rODi7t6wfpg8g Engage & Equip is a resource designed to help form substantive disciples for the local church.Find more episodes at highpointchurch.org/podcastMusic: HOME—We're Finally Landing, Nosebleed, If I'm Wrong (https://midwestcollective.bandcamp.com/album/before-the-night)

In July 2025, approximately 2,000 Gunnison River/Hofer-cross rainbow trout were released into the North Tongue River. The fish were transported more than 650 miles from the Pitkin State Fish Hatchery in Colorado. In addition to being long-distance travelers, the fish are special due to a unique genetic trait - they are resistant to the impacts of whirling disease. Today on "Get Outside" We'll chat with Wyoming Game and Fish Sheridan Region Fisheries Biologist Andrew Nikirk, who monitors this popular fishery...

Robert Jacks, President and CEO of Sparrow Pharmaceuticals, identifies that an elevated cortisol level is a newly recognized cause of treatment-resistant type 2 diabetes. A significant portion of patients with diabetes who do not respond to standard treatments, including GLP-1 agonists, have underlying high cortisol. Sparrow has developed a drug designed to lower cortisol levels inside cells, directly addressing the underlying driver of the disease, and to be used as a complement to existing treatments. This concept of targeting cortisol-driven resistance could be extended to other conditions, such as treatment-resistant hypertension. Robert explains, "I feel as though Sparrow has come full circle, actually, with the mechanism of our drug. Originally, we have a drug that targets HSD-1. We can talk about what that is, but it's involved in intracellular cortisol regulation. This was a class of drugs that was originally developed targeting cardiometabolic diseases like type 2 diabetes. And the drugs had some moderate efficacy, but they weren't well differentiated in a broad population and largely were just discontinued for commercial reasons." "Our company was founded a number of years ago based on the idea that these drugs had real potential but hadn't been used in the right patient population. And that being the patient population with the disease that we know is driven by excess cortisol toxicity, because that's aligned with the mechanism, as I was mentioning. So we generated some really interesting data in a rare disease called Endogenous Cushing syndrome. This is a very severe orphan disease with patients who have very severely elevated cortisol, showing in fact that yes, this mechanism does seem like it could have a very major impact in the right patient population." "Simultaneously, another company published some data showing that actually there's a very large population of people with treatment-resistant type 2 diabetes, a very high level of medical need, and that their underlying disease actually is being driven by elevated levels of cortisol. And so when you bring together the data that we generated and what appears to be a large amount needed in a large population, it seems like we may have the perfect solution for that. So we've refocused our efforts on a broad population of treatment-resistant type 2 diabetes in patients whose disease is being impacted or driven by elevated cortisol levels."  #SparrowPharmaceuticals #Type2Diabetes #CardiometabolicDisease #CortisolRegulation #Cortisol #GLP1 #RareDisease sparrowpharma.com Download the transcript here

Robert Jacks, President and CEO of Sparrow Pharmaceuticals, identifies that an elevated cortisol level is a newly recognized cause of treatment-resistant type 2 diabetes. A significant portion of patients with diabetes who do not respond to standard treatments, including GLP-1 agonists, have underlying high cortisol. Sparrow has developed a drug designed to lower cortisol levels inside cells, directly addressing the underlying driver of the disease, and to be used as a complement to existing treatments. This concept of targeting cortisol-driven resistance could be extended to other conditions, such as treatment-resistant hypertension. Robert explains, "I feel as though Sparrow has come full circle, actually, with the mechanism of our drug. Originally, we have a drug that targets HSD-1. We can talk about what that is, but it's involved in intracellular cortisol regulation. This was a class of drugs that was originally developed targeting cardiometabolic diseases like type 2 diabetes. And the drugs had some moderate efficacy, but they weren't well differentiated in a broad population and largely were just discontinued for commercial reasons." "Our company was founded a number of years ago based on the idea that these drugs had real potential but hadn't been used in the right patient population. And that being the patient population with the disease that we know is driven by excess cortisol toxicity, because that's aligned with the mechanism, as I was mentioning. So we generated some really interesting data in a rare disease called Endogenous Cushing syndrome. This is a very severe orphan disease with patients who have very severely elevated cortisol, showing in fact that yes, this mechanism does seem like it could have a very major impact in the right patient population." "Simultaneously, another company published some data showing that actually there's a very large population of people with treatment-resistant type 2 diabetes, a very high level of medical need, and that their underlying disease actually is being driven by elevated levels of cortisol. And so when you bring together the data that we generated and what appears to be a large amount needed in a large population, it seems like we may have the perfect solution for that. So we've refocused our efforts on a broad population of treatment-resistant type 2 diabetes in patients whose disease is being impacted or driven by elevated cortisol levels."  #SparrowPharmaceuticals #Type2Diabetes #CardiometabolicDisease #CortisolRegulation #Cortisol #GLP1 #RareDisease sparrowpharma.com  Listen to the podcast here

Treating aggressive cancers that do not respond to standard therapies remains one of the most significant challenges in oncology. Among these are basal-like breast cancers (BLBC), which lack hormone receptors and HER2 amplification. This makes them unsuitable for many existing targeted treatments. As a result, therapeutic options are limited, and patient outcomes are often poor. One emerging strategy is to induce senescence, a state in which cancer cells permanently stop dividing but remain metabolically active. This approach aims to slow or stop tumor growth without killing the cells directly. Although promising, the clinical application of senescence-based therapies has been limited by several challenges. Senescence is typically identified using biomarkers such as p16, p21, and beta-galactosidase activity. However, these markers are often already present in aggressive cancers like BLBC (Sen‑Mark+ tumors), making it difficult to determine whether a treatment is truly inducing senescence or merely reflecting the tumor's existing biology. Moreover, conventional screening methods may mistake reduced cell growth for senescence, cell death, or temporary growth arrest, leading to inaccurate assessments. This is especially problematic in large-scale drug screening, where thousands of compounds must be evaluated quickly and reliably. To overcome these issues, researchers from Queen Mary University of London and the University of Dundee have developed a new machine learning–based method to improve the detection of senescence in cancer cells. Their findings were recently published in Aging-US. The Study: Developing the SAMP-Score The study, titled “SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16-positive cancer cells,” was led by Ryan Wallis and corresponding author Cleo L. Bishop from Queen Mary University of London. This paper was featured on the cover of Aging-US Volume 17, Issue 11, and highlighted as our Editors' Choice. Full blog - https://aging-us.org/2025/12/using-machine-learning-to-identify-senescence-inducing-drugs-for-resistant-cancers/ Paper DOI - https://doi.org/10.18632/aging.206333 Corresponding author - Cleo L. Bishop - c.l.bishop@qmul.ac.uk Abstract video - https://www.youtube.com/watch?v=qXI_KI3EgHE Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206333 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, SAMP-Score, senescence, senescent marker positive cancer cells, Sen-Mark+, machine learning, pro-senescence, high-throughput compound screening To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

This episode is sponsored by Lightstone DIRECT. Lightstone DIRECT invites you to partner with a $12B AUM real estate institution as you grow your portfolio. Access the same single-asset multifamily and industrial deals Lightstone pursues with its own capital – Lightstone co-invests a minimum of 20% in each deal alongside individual investors like you. You're an institution. Time to invest like one.-------------------------------------------What do you do when a colleague needs coaching but resists every step? In this essential episode for physician leaders, host Dr. Bradley Block welcomes back Dr. John Schneider, as they explore starting productive conversations with those who don't want to hear it: from remediation for below-standard behavior to subtle issues. Dr. Schneider stresses asking questions from their perspective, building psychological safety, and inviting participation to open doors for change, not pushing through them. He warns against "hammer" approaches like HR escalation unless minimum competencies fail, and shares the "challenge plus support" quadrant: challenge without support leads to retreat; support without challenge stalls growth. Drawing from his roles as Assistant Dean for Faculty Coaching and private practice coach, he emphasizes leading with belief in people, connecting to their original "calling" in medicine, and accepting that not everyone will walk through the door. If you're in leadership facing resistance. This episode offers nuanced, practical strategies to foster trust, inspire evolution, and avoid burnout for you and your team.Three Actionable Takeaways:Start with Their Perspective, Not Yours: When addressing resistance, ask questions that uncover what they need, not what you think they need. Avoid starting from remediation or "hammer" tactics; build psychological safety by showing you believe in them, inviting participation to make change feel meaningful and voluntary.Balance Challenge and Support for Growth: Use the quadrants: Challenge without support causes retreat; support without challenge leads to stagnation. As a leader, consciously provide both, holding accountable while being "with them" to open doors for self-reflection and behavior shifts, even if they don't always step through.Reconnect to Their Original Calling: Remind resistant colleagues of why they chose medicine, the inspiration that's often buried under policies and metrics. Frame changes as ways to rediscover that purpose, making evolution feel like a personal win, not an imposed fix; not everyone changes, but this invites possibility.About the Show:Succeed In Medicine  covers patient interactions, burnout, career growth, personal finance, and more. If you're tired of dull medical lectures, tune in for real-world lessons we should have learned in med school!About the Guest: Dr. John Schneider is the Division Chief of Rhinology and Anterior Skull Base Surgery and Associate Professor at Washington University in St. Louis. He serves as the university's first Assistant Dean for Faculty Coaching and is a Master Certified Physician Development Coach. In addition to his academic and clinical roles, Dr. Schneider runs his own coaching practice called Physicians' Mind Coaching, focused on helping physicians improve self-awareness, leadership, communication, and professional fulfillment. He is a nationally recognized expert in physician coaching, particularly in having difficult conversations, addressing disruptive behavior, building psychological safety, and guiding reluctant physicians toward personal and professional growth. He trains faculty coaches at Wash U and frequently speaks on topics including conflict resolution, the coach approach in leadership, and burnout prevention.Email:   john@physiciansmind.comAbout the Host:Dr. Bradley Block – Dr. Bradley Block is a board-certified otolaryngologist at ENT and Allergy Associates in Garden City, NY. He specializes in adult and pediatric ENT, with interests in sinusitis and obstructive sleep apnea. Dr. Block also hosts Succeed In Medicine podcast, focusing on personal and professional development for physiciansWant to be a guest?Email Brad at brad@physiciansguidetodoctoring.com  or visit www.physiciansguidetodoctoring.com to learn more!Socials:@physiciansguidetodoctoring on Facebook@physicianguidetodoctoring on YouTube@physiciansguide on Instagram and Twitter This medical podcast is your physician mentor to fill the gaps in your medical education. We cover physician soft skills, charting, interpersonal skills, doctor finance, doctor mental health, medical decisions, physician parenting, physician executive skills, navigating your doctor career, and medical professional development. This is critical CME for physicians, but without the credits (yet). A proud founding member of the Doctor Podcast Network!Visit www.physiciansguidetodoctoring.com to connect, dive deeper, and keep the conversation going. Let's grow! Disclaimer:This podcast is for informational purposes only and is not a substitute for professional medical, financial, or legal advice. Always consult a qualified professional for personalized guidance. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Parshat Vayishlakh 

Dr. Natalie Bessom is a board-certified family medicine physician at Hamilton Primary Care - Dalton. She treats mild illnesses and injuries and performs preventive care. For more information about Hamilton Physician Group-Primary Care-Dalton call 706-226-9355 or visit www.vitruvianhealth.com/locations/hamilton-primary-care-daltonThis program in no way seeks to diagnose or treat illness or to replace professional medical care. Please see your healthcare provider if you have a health problem.

Dr. Petri Bono, Chief Medical Officer at Faron Pharmaceuticals, describes the development of bexmarilimad, a novel first-in-class immunotherapy that, unlike existing checkpoint inhibitors targeting T cells, targets the Clever 1 receptor on macrophages. This treatment is designed to reprogram the tumor microenvironment by switching marcophages from suppressive to active, enabling the patient's immune system to recognize and attack cancer cells. The primary disease target is higher-risk Myelodysplastic syndromes because the cancer cells in virtually all MDS patients express the Clever 1 target. Petri explains, "We are developing a completely new type of treatment. Currently, cancer patients are treated with immunotherapies called checkpoint inhibitors that target immune checkpoints. But our approach is targeting completely different cells, not T cells, but rather macrophages. And that's why we are first in class with a novel mode of action. And that's why it's important that these macrophages are shown to, for example, contribute to treatment resistance in many tumors." "Clever 1 actually is a receptor that was identified about 20 years ago. It found a certain macrophage as well as myeloid cells. And Clever 1 keeps the immune system in a tolerant and suppressive state. In cancer, for example, these Clever 1-positive macrophages essentially help the malignancy grow instead of helping to fight against it. And then our approach is that we want to block Clever 1 with our monoclonal antibody, bexmarilimab. So those macrophages switch the phenotype into an active antigen, preventing a pro-inflammatory state, and this reawakens immune surveillance. It allows T cells in the system to actually recognize the malignant cells themselves as dangerous and mount a proper antitumor response. So, a completely new mode of action by targeting Clever 1, we are not just adding another cytotoxic mechanism. We are removing the immune break and enabling the patient's own immune system to do the job that it was originally designed to do."  #FaronPharmaceuticals #BloodCancer #MDS #MyelodysplasticSyndrome #HR-MDS #CancerResearch #novelimmunotherapy #Bexmarilimab #Clever1 faron.com Download the transcript here

Dr. Petri Bono, Chief Medical Officer at Faron Pharmaceuticals, describes the development of bexmarilimad, a novel first-in-class immunotherapy that, unlike existing checkpoint inhibitors targeting T cells, targets the Clever 1 receptor on macrophages. This treatment is designed to reprogram the tumor microenvironment by switching marcophages from suppressive to active, enabling the patient's immune system to recognize and attack cancer cells. The primary disease target is higher-risk Myelodysplastic syndromes because the cancer cells in virtually all MDS patients express the Clever 1 target. Petri explains, "We are developing a completely new type of treatment. Currently, cancer patients are treated with immunotherapies called checkpoint inhibitors that target immune checkpoints. But our approach is targeting completely different cells, not T cells, but rather macrophages. And that's why we are first in class with a novel mode of action. And that's why it's important that these macrophages are shown to, for example, contribute to treatment resistance in many tumors." "Clever 1 actually is a receptor that was identified about 20 years ago. It found a certain macrophage as well as myeloid cells. And Clever 1 keeps the immune system in a tolerant and suppressive state. In cancer, for example, these Clever 1-positive macrophages essentially help the malignancy grow instead of helping to fight against it. And then our approach is that we want to block Clever 1 with our monoclonal antibody, bexmarilimab. So those macrophages switch the phenotype into an active antigen, preventing a pro-inflammatory state, and this reawakens immune surveillance. It allows T cells in the system to actually recognize the malignant cells themselves as dangerous and mount a proper antitumor response. So, a completely new mode of action by targeting Clever 1, we are not just adding another cytotoxic mechanism. We are removing the immune break and enabling the patient's own immune system to do the job that it was originally designed to do."  #FaronPharmaceuticals #BloodCancer #MDS #MyelodysplasticSyndrome #HR-MDS #CancerResearch #novelimmunotherapy #Bexmarilimab #Clever1 faron.com Listen to the podcast here

Bayer Crop Science is introducing a new herbicide to help corn and soybean farmers fight tough, resistant weeds. In this Managing for Profit, Ryan Tierney, Bayer's broad-acre herbicides segment manager, discusses the expected launch of Convinto™ herbicide next season. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you've been doing all the right things—eating clean, exercising, thinking positive—and still not seeing the changes you want… This week I recorded a solo show on Weight-Loss Resistance and the REAL reasons your body isn't changing. (Spoiler: it's not your willpower, your discipline, or your motivation.) I break down the top 7 metabolic blocks I see over and over again, plus the missing link that most programs ignore:

If you've been doing all the right things—eating clean, exercising, thinking positive—and still not seeing the changes you want… This week I recorded a solo show on Weight-Loss Resistance and the REAL reasons your body isn't changing. (Spoiler: it's not your willpower, your discipline, or your motivation.) I break down the top 7 metabolic blocks I see over and over again, plus the missing link that most programs ignore:

If you've been doing all the right things—eating clean, exercising, thinking positive—and still not seeing the changes you want… This week I recorded a solo show on Weight-Loss Resistance and the REAL reasons your body isn't changing. (Spoiler: it's not your willpower, your discipline, or your motivation.) I break down the top 7 metabolic blocks I see over and over again, plus the missing link that most programs ignore:

If you've been doing all the right things—eating clean, exercising, thinking positive—and still not seeing the changes you want… This week I recorded a solo show on Weight-Loss Resistance and the REAL reasons your body isn't changing. (Spoiler: it's not your willpower, your discipline, or your motivation.) I break down the top 7 metabolic blocks I see over and over again, plus the missing link that most programs ignore:

If you've been doing all the right things—eating clean, exercising, thinking positive—and still not seeing the changes you want… This week I recorded a solo show on Weight-Loss Resistance and the REAL reasons your body isn't changing. (Spoiler: it's not your willpower, your discipline, or your motivation.) I break down the top 7 metabolic blocks I see over and over again, plus the missing link that most programs ignore:

This episode is brought to you by Fatty15, WHOOP and Timeline. Dr. Patrick Porter, PhD joins us today to break down what brain fitness really means and why modern life is overwhelming a biological system that was never designed for today's pace. Dr. Porter explains how brain energy, neuroplasticity, breathwork, mitochondria, sleep architecture, stress physiology, light exposure, and daily rituals all influence our ability to think clearly, recover deeply, and perform at a high level. We explore the science behind neurogenesis, the glymphatic system, alpha and delta brainwave states, the impact of sugar and artificial sweeteners on cognitive decline, how breathing and light frequencies regulate the nervous system, and why most people are unknowingly compromising their sleep, metabolism, and cognitive output. Packed with actionable tools—from box breathing and SMR training to healthier morning routines, supplements, and digital hygiene—this episode is a masterclass on how to build a sharper brain and age better. Follow Dr. Porter @drpatrickporter Follow Chase @chase_chewning ----- 00:17 – Neuropruning, neurogenesis & brain voltage explained 01:18 – Why puzzles aren't brain fitness & the need for recovery 02:02 – How neuroplasticity works at any age 03:08 – Challenging the myth that humans can't grow new neurons 03:28 – DNA changes every 40 seconds & mindset's effect on cellular energy 04:42 – Optimism vs. pessimism on brain health 05:31 – The impact of modern sedentary living 08:52 – Light, circadian rhythms & how the body gets biological "codes" 09:54 – Why meditation and ancient practices matter for neuroplasticity 10:44 – The brain's energy demands during sleep 11:13 – Sugar, stress & metabolic dysfunction 12:16 – Tech overload & living in a world we weren't built for 13:19 – Why exercising first thing is harmful if cortisol is high 14:04 – SMR brainwave training & preparing the brain for the day 14:31 – How to enter alpha state through psychological breathing 15:30 – Breathwork as the best pre-workout 16:03 – Memory, aging & how recall networks degrade 17:49 – How environment, food & behavior shape brain performance 18:32 – Brazil study: music + frequencies improve cognitive retention 19:21 – Intelligence is energy, not innate talent 20:42 – Hypernesia, super-memory states & learning faster 21:19 – Stress collapses the brain's energy field 22:25 – The 2 p.m. biological crash & 20-minute reboot method 23:17 – Why you shouldn't drink coffee first thing in the morning 24:05 – WHOOP data & tracking recovery 28:35 – Fire, infrared, and ancient light patterns regulating cortisol 29:06 – Box breathing & Navy SEAL stress control 30:39 – The 4-4-8 breath for nighttime relaxation 31:31 – Photobiomodulation & brainwave entrainment results 32:48 – Cold plunging, testosterone & the body's adaptive response 33:57 – Pain, opioids & training the brain to regulate pain naturally 34:23 – Why TBIs need light—not darkness—for healing 35:02 – What's wrong with modern education 35:36 – Diving deeper into sleep health: "Sleep smarter" 36:28 – Why 6.5 hours may be optimal; deep vs. REM sleep 37:20 – The glymphatic system: brain "washing cycle" 38:12 – Why dehydration & late eating disrupt deep sleep 39:33 – Tracking sleep: analyzing Chase's data 41:08 – Coal miner sleep study: 1 minute of deep sleep 42:11 – Getting to delta faster improves brain repair 42:40 – Why many people clench & never unwind during sleep 43:06 – Breath is the foundation of all emotional regulation 44:11 – Using breath to process problems & create optimism 45:21 – Dementia study: increasing brain voltage reverses symptoms 46:20 – Kids vs. adults: why adults hold stress longer 47:03 – Applying breathwork anywhere in daily life 48:31 – Addiction is one solution to infinite problems—breath creates options 49:15 – Why most affirmations don't work 50:06 – Breath + emotion alignment for manifestation 51:37 – The worst thing for brain health: doing nothing 53:12 – Sugar & artificial sweeteners destroying brain health 54:27 – Pavlov, dopamine loops & our coffee addiction 56:04 – Pandemic stress accelerated brain aging 56:49 – How breath can change immune response & resilience 58:09 – Stress, perception & mitochondrial ATP 59:20 – Red light & brain energy: mitochondria producing 32× ATP 59:55 – Nasal vs. mouth breathing for brain optimization 01:00:23 – Yogic breath, pranayama & hemisphere balancing 01:01:11 – Should you breathe through left or right nostril 01:02:55 – Stress collapses neural function under pressure 01:03:34 – Why people fear brain decline but don't act 01:06:02 – Olive oil daily reduces Alzheimer's risk 01:07:00 – The sugar epidemic: 100 lbs/year 01:07:53 – Supplements: niacin, vitamin C, omega-3s 01:09:59 – How to know if you're inflamed 01:11:49 – Lab markers to track for brain health 01:13:20 – Iron, energy & the body's magnetic fields 01:14:05 – Algae, greens & light-activated nutrient strategies 01:16:23 – Measuring progress: HRV, community, daily walking 01:17:20 – Brain health by decade & sleep hygiene after 40 01:19:20 – Digital hygiene: limit phones after 8 p.m. 01:20:28 – Designing the perfect 24 hours for brain health 01:24:25 – The power of review, gratitude & problem-solving before sleep 01:25:13 – Ever Forward ----- Episode resources: Save an additional 15% on C15:0 essential fatty acids at Fatty15.com/everforward  Save up to $60 on the WHOOP 5.0 activity tracker at Join.Whoop.com/everforward Get a FREE 3-day sample of MitoPure at Timeline.com/everforwardsample Watch and subscribe on YouTube  

November is Epilepsy Awareness Month, and to help raise awareness, TSC Now host Dan Klein talks to Starr Phipps, an adult living with drug-resistant epilepsy. She shares her story, including how she faced stigma as a child, how her lack of control over her seizures impacted her emotional and physical well-being, and how continuing to … Continue reading Episode 51: Drug-Resistant Epilepsy (Sponsored by LivaNova) →

Send comments and feedbackAbout one-third of people with epilepsy will continue having seizures despite medications. What is the clinical definition of drug-resistant epilepsy? Why does it occur, and is it possible to predict? Dr. Cecilie Nome interviews Dr. Patrick Kwan.Relevant papers:Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies - Kwan - 2010 - Epilepsia - Wiley Online LibraryThe costs of epilepsy in Australia | Neurology Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice.Let us know how we're doing: podcast@ilae.org.The International League Against Epilepsy is the world's preeminent association of health professionals and scientists, working toward a world where no person's life is limited by epilepsy. Visit us on Facebook, Instagram, and LinkedIn.

95% of agents are struggling right now, but you can survive a shifting real estate market. The secret is not luck; it is mastering lead generation for real estate using a hidden source: probate listings.In this episode, I provide your ultimate market crash survival guide. We stop relying on expensive online leads and start searching probate court records to find motivated seller leads with high equity.Most agents fail because they lack a system. I will teach you the exact probate cold calling approach that actually works today. You do not need to be aggressive; you just need the right cold calling scripts for real estate agents to open the door.By the end, you will know how to position yourself as a specialized probate real estate agent and secure listings others miss.✅ How to master lead generation for real estate in a low inventory market ✅ The specific steps for searching probate court records ✅ Cold calling scripts for real estate agents (The "Soft" Approach) ✅ Why becoming a probate real estate agent protects your income ✅ The truth about real estate coaching and training for 2025If you are ready to fix your real estate business and stop worrying about where your next deal is coming from, this masterclass is for you.

Beyond the Sessions is answering YOUR parenting questions! In this episode Dr. Emily Upshur and I talk about...   - Why kids often say "this is boring" when something actually feels too hard or frustrating. - How to tell whether your child's struggle with schoolwork might be about motivation, confidence, or a deeper learning challenge. - What to do when tutoring or extra practice starts leading to power struggles or resistance. - The pros and cons of reward systems, and how to use incentives in a way that truly motivates your child (without creating more stress). - When to consider a school-based or private evaluation—and how to know which supports will make the biggest difference for your child's unique struggles.   If your child has started saying they "hate school" or "reading is boring" this episode will help you understand what's really driving that resistance and give you practical, compassionate ways to make learning feel lighter, more motivating, and even fun again.     REFERENCES AND RELATED RESOURCES:  

Sometimes healing feels more like trial and error than progress. Brian Livesay knows that firsthand. After a decade in uniform and years working in veteran care, he's learned that recovery is about connection, honesty, and finding what actually works for each person. In this conversation, Brian and Scott talk about how therapy can go wrong when it's too rigid, the fear of making that first call for help, and why moral injury still gets overlooked in veteran care. It's a hopeful look at what happens when we stop trying to "fit" into a treatment plan and start listening to what we really need. Timestamps: 00:06:24 - Why "treatment-resistant PTSD" misses the mark 00:11:19 - Making the first call and facing the unknown 00:15:00 - How trust opens the door to healing 00:21:00 - The weight of moral injury 00:38:30 - A therapist's real job: guide, not fixer Links & Resources Veteran Suicide & Crisis Line: Dial 988, then press 1 Website: https://arisealliance.org/ Follow Arise Alliance Institute on Facebook: https://www.facebook.com/AriseAllianceInstitute/ Follow Arise Alliance Institute on Instagram: https://www.instagram.com/ariseallianceinstitute/ Follow Arise Alliance Institute on Twitter/X: https://www.instagram.com/ariseallianceinstitute/ Follow Arise Alliance Institute on LinkedIn: https://www.linkedin.com/company/arise-alliance/ Transcript View the transcript for this episode.

Secure sign-in across all your devices without relying on passwords or extra apps using passkeys in Microsoft Entra. Register, sync, and use passkeys with just your device's camera and biometrics, making authentication seamless, fast, and phishing-resistant. As an admin, control who uses which passkey type, streamline recovery with Verified ID, and automatically remediate risk in real time. Jarred Boone, Identity Security Senior Product Manager, shows how users can access work apps safely, confidently, and efficiently while reducing help desk overhead. ► QUICK LINKS:  00:00 - Passkeys in Microsoft Entra ID 01:19 - Register your passkey 02:12 - Authenticate into apps & services 03:34 - Sync passkeys on updated devices 04:16 - Configure passkeys as an admin 05:51 - Account recovery 07:18 - Conditional Access policies 07:53 - Wrap up ► Link References Check out https://aka.ms/PasskeysInEntra  ► Unfamiliar with Microsoft Mechanics? As Microsoft's official video series for IT, you can watch and share valuable content and demos of current and upcoming tech from the people who build it at Microsoft. • Subscribe to our YouTube: https://www.youtube.com/c/MicrosoftMechanicsSeries • Talk with other IT Pros, join us on the Microsoft Tech Community: https://techcommunity.microsoft.com/t5/microsoft-mechanics-blog/bg-p/MicrosoftMechanicsBlog • Watch or listen from anywhere, subscribe to our podcast: https://microsoftmechanics.libsyn.com/podcast ► Keep getting this insider knowledge, join us on social: • Follow us on Twitter: https://twitter.com/MSFTMechanics • Share knowledge on LinkedIn: https://www.linkedin.com/company/microsoft-mechanics/ • Enjoy us on Instagram: https://www.instagram.com/msftmechanics/ • Loosen up with us on TikTok: https://www.tiktok.com/@msftmechanics  

This week we sat down with Antonin Bonnet from Pierre and Antonin in the south of France for an eye opening episode. Antonin is a natural winemaker and he pulled back the curtain on how he and his partner Pierre think about and make wine without all the scary stuff people usually associate with natural bottles.We got into his wild start in New York, how he and Pierre built their winery from scratch, and why resistant grape varieties might be the future. Colin finally owned his natural wine skepticism, Joel showed up mid-diaper-chaos, and Antonin kept dropping gems while pouring wines that shook up our expectations.If you've ever been curious about natural wine or flat out opposed to it, this episode might flip your perspective. Grab a glass, hit play, and get ready to think about wine in a new way.Check out Pierre and Antonin Pierre and Antonin Websitehttps://pierre-antonin.com/en/Pierre and Antonin on Instagramhttps://www.instagram.com/pierreetantonin/Connect with the show. We would love to hear from you!Stop Wasting Your Wine on Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/stopwastingyourwine/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Stop Wasting Your Wine on YouTube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@StopWastingYourWine⁠⁠⁠⁠The Stop Wasting Your Wine Website⁠⁠⁠https://stopwastingyourwine.com/⁠00:00 Intro and Welcome01:02 Meet Antonin Bonnet from Pierre and Antonin02:42 First Natural Wine on the Show04:10 How Antonin and Pierre Met in NYC07:15 Discovering Natural Wine in Brooklyn09:55 Colin Admits His Natural Wine Fears11:40 Avoiding Funk and Flaws in Natural Wine14:15 Fermentation, Acidity, and Staying Clean17:40 Resistant Grapes Explained21:30 Sustainable Viticulture and No Chemicals24:10 Packaging and Carbon Footprint Choices27:05 Why Take the Hard Road in Winemaking30:20 Making Natural Wine That Still Tastes Great34:05 Growing a Winery From Scratch37:20 Selling Wine in the US Market40:30 Tradition vs Innovation44:00 Lessons from Early Vintages46:55 Future of Resistant Varieties49:20 Final Thoughts and Takeaways52:35 Sips, Laughs, and Goodbyes

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter breaks down the science of dietary fiber, moving beyond the blanket advice to "eat more fiber" to uncover what it actually does in the body and where its benefits are truly supported by evidence. He explains how different types of fiber—soluble, insoluble, viscous, and fermentable—affect digestion, satiety, weight management, and glycemic control, and compares their impact to other, more potent metabolic tools. Peter also examines how certain fibers influence lipid metabolism and cardiovascular risk, evaluates the strength of evidence for fiber's role in colorectal cancer prevention, and highlights why some individuals may not tolerate specific fibers well. The discussion concludes with practical guidance on moving past generic fiber targets toward a more strategic and personalized approach that maximizes the true benefits of fiber. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #77 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Why it's time to re-examine the evidence behind dietary fiber recommendations [2:00]; Why it's hard to isolate fiber's true effects on health: the limits of nutritional epidemiology [5:45]; Defining dietary fiber: what it is, how it's digested, and why different types have different effects [8:15]; Understanding fiber properties: how solubility, viscosity, and fermentability shape its effects in the body [11:15]; Resistant starches explained: types, food sources, and how cooking and cooling influence their benefits [16:30]; A framework for evaluating each of the major health claims linked to fiber [19:15]; How fiber can support weight loss: mechanisms, realistic expectations, and its complementary role to broader dietary strategies [20:30]; How fiber modestly improves glycemic control by reducing glucose spikes and insulin demand [26:15]; How fiber modestly lowers LDL cholesterol and supports cardiovascular health [34:30]; How fiber compares to other available tools and strategies for managing lipids, blood sugar, and weight [42:00]; Fiber's role in colon cancer prevention: mechanisms, evidence, and limitations [45:30]; Is fiber necessary for colon cancer prevention in otherwise healthy individuals? [53:30]; Why some people have adverse reactions to certain types of fiber, and how to manage them [56:00]; A general strategy for dietary fiber: combine multiple fiber types through whole foods and supplements [58:45]; Why total fiber intake is more important than the ratio of soluble-to-insoluble fiber [1:02:45]; The optimal timing and context for consuming fiber to maximize blood sugar control and metabolic benefits [1:05:00]; How food processing affects the functional properties of fiber, the differences between supplement forms and natural sources, and why whole foods generally remain the best option [1:06:45]; Fiber's potential to interfere with medication absorption [1:09:30]; How to safely increase fiber intake: ramp up gradually and stay hydrated [1:12:00]; Final takeaway on fiber: modest benefits, strong rationale, low downside [1:13:00]; Peter's carve-out: lessons and inspiration from the Acquired podcast [1:14:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Jonathan Greene sits down with self-storage investor and operator Joe Downs, CEO of Bellrose Storage Group, which sources, acquires, and manages self-storage facilities across the East and Southeast. With a background in commercial real estate, capital raising, and distressed second mortgages, Joe explains how he pivoted into self-storage after discovering just how mom-and-pop dominated and under-optimized the space really was. Their conversation explores why self-storage is still far from "too late," how technology and remote management have transformed operations, and why small, overlooked facilities under 30,000 square feet can be a goldmine for investors willing to modernize them. Joe also breaks down creative plays like boat and RV storage, industrial outdoor storage, and converting large vacant retail boxes into multi-revenue storage campuses. Listeners will come away with a grounded understanding of why self-storage is such a powerful niche, what to look for in a mom-and-pop facility, and how to avoid overpaying by underwriting expenses correctly. Joe and Jonathan also discuss the importance of relationships and "caretaker" mentality with long-time owners, the role of SBA loans, and how to keep shiny object syndrome in check while still recognizing adjacent opportunities. In this episode, you will hear: How Joe went from distressed debt and 1031 capital raising to building a self-storage platform Why self-storage is still largely mom-and-pop owned and what that means for opportunity How technology, remote management, and autopay have transformed facility operations What to look for in a first small storage acquisition and how to approach owners as a "caretaker" The importance of underwriting real expenses (marketing, tech, management) so you don't overpay Creative self-storage derivatives, including boat and RV storage, IOS, and big-box retail conversions Follow and Review If you enjoy the show, please follow Zen and the Art of Real Estate Investing on Apple Podcasts and leave a rating and review. It helps other listeners discover these conversations and supports the show's growth.   Supporting Resources Connect with Joe Downs: Website: https://belrosegrp.com/ Facebook: https://www.facebook.com/belrosestoragegroup Twitter: @downsjoe LinkedIn: https://www.linkedin.com/in/joe-downs-7990851/ Connect with Jonathan: Website - www.streamlined.properties  YouTube - www.youtube.com/c/JonathanGreeneRE/videos  Instagram - www.instagram.com/trustgreene  Instagram - www.instagram.com/streamlinedproperties    Zillow - www.zillow.com/profile/streamlinen​j Bigger Pockets -  www.biggerpockets.com/users/jonathangreene Facebook - www.facebook.com/streamlinedproperties  Email - info@streamlined.properties    This episode was produced by Outlier Audio.   

Today we will review some of the more common diseases and fungi that limit yields and even sometimes totally destroy vegetable plants along with some varieties of seed that have disease resistance built into them.  More importantly we discuss how to identify a disease vs. pest damage vs. nutrient deficiency and what to do about them and specifically how to find disease resistant varieties based on your individual needs. The original show was titled Episode-2460- Understanding Disease Resistant Vegetable Varieties and was first published on 6-27-2019. Resources for today's show-… Find Me on Nostr Follow Me on Tik-Tok Article Explaining … Continue reading →

Join us for an incredibly candid and informative conversation with Audrey Vernick, a passionate advocate and the Director of Patient and Family Advocacy for the Pediatric Epilepsy Surgery Alliance. Audrey shares the powerful 21-year journey of her son, Bennett, who suffered a stroke in utero and was later diagnosed with the catastrophic epilepsy known as Infantile Spasms. Audrey recounts the emotional process from the difficult labor and early concerns dismissed as normal reflexes, to the terrifying moment she saw his MRI and realized half of his brain was black due to a massive stroke. This episode is an essential listen for any parent navigating a serious pediatric diagnosis, especially those dealing with seizures. Audrey shares her family's ultimate decision to pursue a hemispherectomy after two years of failed medications, and the immediate, miraculous developmental explosion in her son's language and physical abilities post-surgery. Key Takeaways and Actionable Advice Trust Your Parental Instinct: If you think something is wrong with your child's movements, something probably is. Demand a Specialist: If you suspect Infantile Spasms, go to the ER and demand to speak to a neurologist or epileptologist. Request video EEG monitoring. Video & Log Everything: Record videos of suspicious movements and log details (time, duration, what you observed) to help clinicians with diagnosis and treatment planning. The Difference Between a Consult and Surgery: A surgical consult is not a surgery. Referring for a pre-surgical workup opens up a new toolbox of solutions and gives you access to a world-renowned team of specialists for a more detailed look at your child's case. Drug-Resistant Epilepsy (DRE): Epilepsy is considered DRE if a child has uncontrolled seizures after appropriately failing two seizure medications. This increases the risk of SUDEP (Sudden Unexplained Death due to Epilepsy). Decision-Making: Understanding your partner's decision-making style is crucial when navigating complex medical choices. Guest Information & Resources Guest: Audrey Vernick, Director of Patient and Family Advocacy at the Pediatric Epilepsy Surgery Alliance. Organization: Pediatric Epilepsy Surgery Alliance Website: epilepsysurgeryalliance.org. Resources: Offers a Parent Support Navigator Program (trained peers), financial aid for travel to a Level Four epilepsy center for pre-surgical workups, webinars, and more. Infantile Spasms Resource: Audrey also mentions the Infantile Spasms Action Network for resources on recognizing and acting on infantile spasms.   Time Stamp Description Key Information 00:00:43 Critical Advice: Surgery Consult vs. Surgery Audrey shares the core message that a surgery consult is different than a surgery, and there is no harm in seeking a consultation for any diagnosis. 00:01:54 Bennett's Diagnosis and Surgery Audrey introduces her son, Bennett (21), who had a stroke in utero, infantile spasms, and ultimately a hemispherectomy. 00:04:50 The Early Months: Colic vs. Seizures Audrey describes the first five months, where unusual movements and fussiness were initially dismissed as normal reflexes and colic by her pediatrician. 00:12:08 Emergency EEG & Stroke Discovery The night she called a new neurologist, they were admitted for a 48-hour video EEG monitoring. The next day, an MRI revealed a massive stroke in the right hemisphere. 00:14:50 Infantile Spasms: Recognize the Signs Audrey, as a leader of the PESA, stresses that Infantile Spasms is a medical emergency. She describes the signs: head drop/nod, flexing, and subtle movements that happen in clusters. 00:17:10 Advocacy: How to Get Help Advice for parents: Take videos, take logs, and at the ER, demand to see a neurologist or epileptologist. 00:22:15 The Surgical Seed is Planted Bennett's first neurologist mentioned a hemispherectomy when he was only five months old, which her husband immediately dismissed, but planted a "seed" for future research. 00:24:09 Choosing Surgery and the "Elmo Song" Miracle The family begged for surgery and two days later Bennett had his hemispherectomy. Two weeks later on the plane home, Bennett, whose speech was suppressed, sang the entire Elmo song, signaling the impact the seizures had been having. 00:30:52 Defining Drug-Resistant Epilepsy (DRE) DRE is when a child has seizures after failing two appropriately dosed medications. DRE is harmful to development and carries the highest risk of SUDEP (Sudden Unexplained Death due to Epilepsy). 00:42:55 Final Message: Trust Yourself Audrey's final, powerful advice to parents: You are the expert in your own child; trust yourself and use that expertise as a tool on your journey.   Support the Host & Show If you found value in this conversation, please check out host Katie Taylor's work and community resources: Join Katie Taylor's Substack for in-depth insights and articles: Join here Get the SupportSpot App—a helpful tool to support your child through their healthcare journey: Check it out The Child Life On Call Podcast is for informational and educational purposes only. The content shared in each episode, including stories, discussions, and interviews, is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you heard on this podcast. The views and opinions expressed by guests on the Child Life On Call Podcast are their own and do not necessarily reflect those of Child Life On Call. Child Life On Call does not endorse any specific medical treatments, procedures, or opinions shared in the podcast. If you or your child is experiencing a medical emergency, call 911 or seek immediate medical attention. By listening to this podcast, you acknowledge that Child Life On Call and its affiliates are not responsible for any decisions made based on the information provided.  

Sometimes behavior looks like defiance—but what if it's actually a missing skill? In this episode, Audra walks you through a simple visual tool to help determine whether a student's challenging behavior is due to a skill deficit (“can't”) or a motivation issue (“won't”). Using her quadrant graphic, she explains the four learner profiles (Engaged, Frustrated, Avoidant, Resistant) and gives practical strategies for supporting each one.Whether you're a teacher, para, or BCBA, this is a must-listen for decoding behavior and supporting students in meaningful ways.

Rush University Medical Center offers a comprehensive range of surgical options for patients with drug-resistant epilepsy and complex brain tumors, using advanced techniques that include stereo EEG monitoring, laser ablation, resection, and neuromodulation devices such as responsive nerve stimulation and deep brain stimulation.   Arka Mallela, MD, is an epileptic neurosurgeon at Rush. He leads the epilepsy surgery and brain mapping practices where he evaluates and treats patients with drug-resistant epilepsy and brain tumors. In addition, Dr. Mallela specializes in removing difficult brain tumors located near areas that control speech, movement and cognition. He uses brain mapping techniques to safely remove as much of the tumor as possible while protecting these important functions. 

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Note: This episode deals with wildfires and the damage they inflict on the built environment, topics that some may find challenging. Between 1980 and 2023 the U.S. had 22 wildfires that individually caused more than $1 billion in damage, with 18 of those occurring since 2000, according to the National Oceanic and Atmospheric Administration. Wildfire seasons are lasting longer and fires are causing more damage. In this episode of Sustainability Leaders, Alma Cortes Selva, Senior Advisor with the BMO Climate Institute, sits down with Dr. Kimiko Barrett, Wildfires Researcher and Policy Analyst with Headwaters Economics.

Click here for the DRB Daily Sign Up form! TODAY'S SCRIPTURE: Job 9-10; Acts 13-14 Click HERE to give! Get Free App Here! One Year Bible Podcast: Join Hunter and Heather Barnes on 'The Daily Radio Bible' for a daily 20-minute spiritual journey. Engage with scripture readings, heartfelt devotionals, and collective prayers that draw you into the heart of God's love. Embark on this year-long voyage through the Bible, and let each day's passage uplift and inspire you. TODAY'S EPISODE: Welcome to the Daily Radio Bible! In today's episode, host Hunter walks with us through day 295 of our journey in Scripture. We'll be diving into Job chapters 9 and 10, exploring Job's honest wrestling with suffering and God's justice, and then traveling to the book of Acts, chapters 13 and 14, where Barnabas and Paul boldly proclaim the life-changing message of Christ's grace—a message that meets both miraculous acceptance and real resistance. Hunter encourages us to draw courage from the grace that meets us where we are, reminding us that in a “grace-resistant world,” it's only through Christ's love that our lives are transformed. The episode is filled with heartfelt prayers, reflections on what it means to belong to God's family, and an invitation to keep moving forward together, one step at a time, opening our hearts to the living Word. So take a moment, settle in, and let God's Word direct your heart today. You're loved, you're invited, and you're not alone on this journey. Let's get started! TODAY'S DEVOTION: Living in Grace in a Grace-Resistant World. The beautiful message brought by Barnabas and Paul is God's grace—for all people, Jew and Gentile alike. All are invited, all are included, into the triune life of God. What does that look like in real life? This grace isn't earned by obedience to the law, personal piety, or virtue. It comes simply through Christ and what He has done. Jesus, God's Messiah, has offered Himself on the cross as humanity's answer—an answer to sin and death, an answer that gives us power to live this life today. The Holy Spirit fills us and empowers us. This message of grace has real, transformative power. It has the power to change your life, my life, every human life. But as powerful and good and gracious as this message is, it meets resistance. Other powers, other messages, seek to steer our lives. Often, we find ourselves colluding with those lesser powers, trying to survive in this broken world. But when we do, we survive as slaves—not as sons and daughters. True freedom comes only when we embrace grace, when we truly step into the life Christ offers. In Him, we're set free. Our eyes are opened—to see Him and to know who we are in Him. We're given power, by His Spirit, to live this life now in Him. But don't be fooled; the world resists grace. Paul and Barnabas remind the believers in Acts 14:22, “We must suffer many hardships to enter the Kingdom of God.” This is a grace-resistant world. But it's only grace—the grace of Christ—that brings true life and transformation. It's only Him. Are you facing resistance? Don't be surprised. Draw courage from the fact that grace has come to you, has found you, has included you. Christ has offered His life for you. So rejoice now! Let this powerful message of Christ's grace meet you, comfort you, and confront every resistant place in your heart, so He can transform you completely, by His love. That's a prayer I have for my own soul. That's a prayer I have for my family, for my wife, my daughters, my son. And that's a prayer I have for you. May it be so. TODAY'S PRAYERS: Lord God Almighty and everlasting father you have brought us in safety to this new day preserve us with your Mighty power that we might not fall into sin or be overcome by adversity. And in all we do, direct us to the fulfilling of your purpose  through Jesus Christ Our Lord amen.   Oh God you have made of one blood all the peoples of the earth and sent your blessed son to preach peace to those who are far and those who are near. Grant that people everywhere may seek after you, and find you. Bring the nations into your fold, pour out your Spirit on all flesh, and hasten the coming of your kingdom through Jesus Christ our Lord, Amen.   And now Lord,  make me an instrument of your peace.  Where there is hatred let me sow love. Where there is injury, pardon.  Where there is doubt, faith. Where there is despair, hope.  Where there is darkness, light.  And where there is sadness,  Joy.  Oh Lord grant that I might not seek to be consoled as to console. To be understood as to understand, to be loved as to love.  For it is in the giving that we receive, in the pardoning that we are pardoned, it is in the dying that we are born unto eternal life.  Amen And now as our Lord has taught us we are bold to pray... Our Father who art in heaven, hallowed be thy name, thy kingdom come thy will be done on earth as it is in heaven, give us this day our daily bread, and forgive us our tresspasses as we forgive those who trespass against us, and lead us not unto temptation, but deliver us from evil, for thine is the Kingdom and the power and the glory forever. Amen. Loving God, we give you thanks for restoring us in your image. And nourishing us with spiritual food, now send us forth as forgiven people, healed and renewed, that we may proclaim your love to the world, and continue in the risen life of Christ.  Amen.  OUR WEBSITE: www.dailyradiobible.com We are reading through the New Living Translation.   Leave us a voicemail HERE: https://www.speakpipe.com/dailyradiobible Subscribe to us at YouTube: https://www.youtube.com/@Dailyradiobible/featured OTHER PODCASTS: Listen with Apple Podcast DAILY BIBLE FOR KIDS DAILY PSALMS DAILY PROVERBS DAILY LECTIONARY DAILY CHRONOLOGICAL  

Research Finds a High Abundance of Previously Unknown Antibiotic-Resistant Genes in BacteriaBy Today's RDH ResearchOriginal article published on Today's RDH: https://www.todaysrdh.com/research-finds-a-high-abundance-of-previously-unknown-antibiotic-resistant-genes-in-bacteria/Need CE? Start earning CE credits today at https://rdh.tv/ce Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/

In this episode, I sit down with Terry Arko from HASA to dive deep into one of the toughest pool problems out there — chlorine-resistant algae, including the dreaded black algae that laughs at your shock treatments. We talk about why some algae survive even in well-maintained pools, how biofilms protect them, and what steps actually work to beat them for good. Terry shares his expert insight from decades in the field, breaking down the myths and science behind stubborn algae blooms. If you've ever felt like your chlorine isn't doing its job, this one's a must-listen.Send us a textSupport the Pool Guy Podcast Show Sponsors! HASA https://bit.ly/HASAThe Bottom Feeder. Save $100 with Code: DVB100https://bit.ly/THEBOTTOMFEEDERTry Skimmer FREE for 30 days:https://getskimmer.com/poolguy Get UPA Liability Insurance $64 a month! https://forms.gle/F9YoTWNQ8WnvT4QBAPool Guy Coaching: https://bit.ly/40wFE6y Thanks for listening, and I hope you find the Podcast helpful! For other free resources to further help you:Visit my Website: https://www.swimmingpoollearning.comWatch on YouTube: https://www.youtube.com/@SPLPodcast Site: https://the-pool-guy-podcast-show.onpodium.com/ UPA General Liability Insurance Application: https://forms.gle/F9YoTWNQ8WnvT4QBA Pool Guy Coaching Group Join an exclusive network of Pool Service Technicians to access the industry's leading commercial general liability insurance program. Protect your business. Premium is $64 per month per member (additional $40 for employees and ICs) $59 per month for Pool Guy coaching Members - join here! https://www.patreon.com/poolguycoaching Limits are $1,000,000 in occurrence and $2,000,000 in the aggregate - Per member limits [ $1,000,000 per occurrence and $4,000,000 aggregate available for $75 per month ] $50,000 in HazMat Coverage - clean up on-site or over-the-road Acid Wash Coverage - Full Limits

This story is a mirror to Elizabeth's story from season 1 episode 1. Today's storyteller Sarah was so moved by Elizabeth's story that it helped her to trust Dr. H's recommendation to take a pretty scary medication, the extremely powerful antipsychotic and mood stabilizer called clozapine. So why tell this story again? As they say, history doesn't repeat itself, but it does often rhyme, and Sarah's story rhymes beautifully with Elizabeth's. Both had severe and treatment resistant bipolar 1 disorder, formerly known as manic-depression. Both tried all the meds, did all the things, then eventually reached a point of utter hopelessness and despair….and then they had to trust Dr. H enough to try one more thing.Support the show! https://www.buzzsprout.com/396871/support"I Love You, I Hate You, Are You My Mom?"  An intensive experiential workshop exploring transference with Dr. H and Dr. Hillary McBride, Feb 4th-6th 2026 in Joshua Tree, CA https://www.craigheacockmd.com/i-love-you-i-hate-you-are-you-my-mom/BFTA episode recommendations/Podcast pagehttps://www.craigheacockmd.com/podcast-page/Support the show

Preaching for the Twenty-ninth Sunday in Ordinary Time, Sister Jessica Kerber offers a reflection on living resistant hope: "Hope indeed is something to live into, sometimes requiring persistence and that resistant hope. For as Scripture promises us: hope does not disappoint."Sister Jessica Kerber is a Handmaid of the Sacred Heart of Jesus, currently serving as both formator and United States Provincial. At Saint Louis University's Center for Ignatian Service, she teaches courses that integrate faith and service. A graduate of Valparaiso University in elementary education, she later completed philosophy and theology studies at Comillas Pontifical University in Madrid.Visit www.catholicwomenpreach.org/preaching/10192025 to learn more about Sr. Jessica, to read her preaching text, and for more preaching from Catholic women.

Planting disease-resistant vegetables helps you harvest longer and avoid losing entire crops to common problems like blight, mildew, and viral infections Hybrids such as Mountain Merit tomato and Emerald Delight zucchini are bred to block or slow pathogens, giving you more reliable yields Heirlooms like Black Cherry tomato and Homemade Pickles cucumber show natural resilience, allowing you to save seeds while keeping your garden productive Seed catalogs and databases provide easy codes and guides so you can choose the varieties that match the disease pressures in your region Combining resistant plants with smart practices — like mulching, crop rotation, and removing infected leaves — further protects your harvest and reduces stress

In this episode of the Real Estate Pros podcast, host Kristen interviews Mary Butler-Stonewall, founder of Architectural Environmental Survival Designs for Tomorrow. The conversation focuses on the critical need for building code reform to enhance sustainability and disaster prevention. Mary shares her lifelong mission to create structures that harmonize with nature, emphasizing the importance of innovative architectural practices that can withstand natural disasters. She discusses her work with impoverished communities, the impact of building codes on climate change, and the necessity for legislative changes to address health and safety issues in construction. The episode concludes with a call to action for listeners to support these vital reforms.   Professional Real Estate Investors - How we can help you: Investor Fuel Mastermind:  Learn more about the Investor Fuel Mastermind, including 100% deal financing, massive discounts from vendors and sponsors you're already using, our world class community of over 150 members, and SO much more here: http://www.investorfuel.com/apply   Investor Machine Marketing Partnership:  Are you looking for consistent, high quality lead generation? Investor Machine is America's #1 lead generation service professional investors. Investor Machine provides true ‘white glove' support to help you build the perfect marketing plan, then we'll execute it for you…talking and working together on an ongoing basis to help you hit YOUR goals! Learn more here: http://www.investormachine.com   Coaching with Mike Hambright:  Interested in 1 on 1 coaching with Mike Hambright? Mike coaches entrepreneurs looking to level up, build coaching or service based businesses (Mike runs multiple 7 and 8 figure a year businesses), building a coaching program and more. Learn more here: https://investorfuel.com/coachingwithmike   Attend a Vacation/Mastermind Retreat with Mike Hambright: Interested in joining a “mini-mastermind” with Mike and his private clients on an upcoming “Retreat”, either at locations like Cabo San Lucas, Napa, Park City ski trip, Yellowstone, or even at Mike's East Texas “Big H Ranch”? Learn more here: http://www.investorfuel.com/retreat   Property Insurance: Join the largest and most investor friendly property insurance provider in 2 minutes. Free to join, and insure all your flips and rentals within minutes! There is NO easier insurance provider on the planet (turn insurance on or off in 1 minute without talking to anyone!), and there's no 15-30% agent mark up through this platform!  Register here: https://myinvestorinsurance.com/   New Real Estate Investors - How we can work together: Investor Fuel Club (Coaching and Deal Partner Community): Looking to kickstart your real estate investing career? Join our one of a kind Coaching Community, Investor Fuel Club, where you'll get trained by some of the best real estate investors in America, and partner with them on deals! You don't need $ for deals…we'll partner with you and hold your hand along the way! Learn More here: http://www.investorfuel.com/club   —--------------------

It can be tempting to step in and “just do it” when your child struggles, whether it's opening a tricky package, making a sandwich that keeps falling apart, or facing the frustration of trying something new. But every time we take over, we unintentionally miss a chance to build their confidence and problem-solving skills.Today, I'll share practical ways to reinforce independence while staying calm and connected. You'll learn how to support your child through the frustration without rescuing, and how to balance encouragement with connection so they gain skills and emotional resilience.Helping kids become more independent doesn't just teach them to do things on their own, it teaches them that they can try, fail, and succeed while knowing you're there to support them.Jennifer's Takeaways:Encouraging Independence in Children (00:00)Understanding Personal Responses (02:38)Supportive Techniques for Independence (04:35)Encouraging Phrases and Micro Boundaries (06:45)Personalized Approaches and Long-term Practice (10:15)Meet Jennifer KolariJennifer Kolari is the host of the “Connected Parenting” weekly podcast and the co-host of “The Mental Health Comedy” podcast. Kolari is a frequent guest on Nationwide morning shows and podcasts in the US and Canada. Her advice can also be found in many Canadian and US magazines such as; Today's Parent, Parents Magazine and Canadian Family.Kolari's powerful parenting model is based on the neurobiology of love, teaching parents how to use compassion and empathy as powerful medicine to transform challenging behavior and build children's emotional resilience and emotional shock absorbers.Jennifer's wisdom, quick wit and down to earth style help parents navigate modern-day parenting problems, offering real-life examples as well as practical and effective tools and strategies.Her highly entertaining, inspiring workshops are shared with warmth and humour, making her a crowd-pleasing speaker with schools, medical professionals, corporations and agencies throughout North America, Europe and Asia.One of the nation's leading parenting experts, Jennifer Kolari, is a highly sought- after international speaker and the founder of Connected Parenting. A child and family therapist with a busy practice based in San Diego and Toronto, Kolari is also the author of Connected Parenting: How to Raise A Great Kid (Penguin Group USA and Penguin Canada, 2009) and You're Ruining My Life! (But Not Really): Surviving the Teenage Years with Connected Parenting (Penguin Canada, 2011).

Australian scientists test the strength of shark bite-resistant wetsuits. An Egyptian wrestler, Ashraf Mahrous, is hoping he has set a world record after pulling a 700-ton ship with his teeth. Police in Northern California pulled over a Waymo taxi after it made an illegal U-turn. The Rockies will begin the search for a new general manager after Bill Schmidt steps down. Titans rookie QB Cam Ward is not having a great season so far. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

On this week's episode of Passive Income Playbook, Pascal Wagner interviews Sean Smith. They dig into the search fund landscape from traditional and self-funded models to independent sponsors, why the silver tsunami and SBA financing make now a compelling moment, and Sean's thesis of backing essential businesses serving attractive end markets. Sean also walks through his four-part diligence system and a 200+ point checklist, how he evaluates terms so LPs are actually protected, and what realistic deal flow looks like when you're only closing on roughly 2 percent of what you review. If you're curious how to be a sharper LP in small business acquisitions without running a company yourself, this one's your roadmap. Sean SmithCurrent role: Managing Partner, Search Fund VenturesBased in: Chicago, IllinoisSay hi to them at: https://www.searchfundventures.co/ | Linkedin This is a limited time offer, so head over to aspenfunds.us/bestever to download the investor deck—or grab their quick-start guide if you're brand new to oil and gas investing. Visit investwithsunrise.com to learn more about investment opportunities.  Get 50% Off Monarch Money, the all-in-one financial tool at www.monarchmoney.com with code BESTEVER Get a 4-week trial, free postage, and a digital scale at ⁠https://www.stamps.com/cre⁠. Thanks to Stamps.com for sponsoring the show! Join the Best Ever Community  The Best Ever Community is live and growing - and we want serious commercial real estate investors like you inside. It's free to join, but you must apply and meet the criteria.  Connect with top operators, LPs, GPs, and more, get real insights, and be part of a curated network built to help you grow. Apply now at ⁠www.bestevercommunity.com⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices