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All you need to know about the latest evidence based practice in the diagnosis and management of immune related toxicities from cancer therapies straight from the experts in the field.

Afreen Shariff


    • Feb 8, 2022 LATEST EPISODE
    • infrequent NEW EPISODES
    • 23m AVG DURATION
    • 20 EPISODES


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    Latest episodes from Checkpoint NOW

    Episode 19: ICI use in Special Populations

    Play Episode Listen Later Feb 8, 2022 40:34


    Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they talk to expert oncologists Dr. Sharon and Dr. Nagash to learn about Immune Checkpoint Inhibitors in special populations. Dr. Sharon is an accomplished Oncologist at the National Cancer Institute. He co-Directs immunotherapy trials at the Cancer Therapy Evaluation Program (also known as CTEP) and serves as an attending physician in NCI's Developmental Therapeutics Clinic. As part of his work in immunotherapy drug development, he has made a major effort to advance the understanding of immune-related adverse events, including the establishment of the Alliance-NIH irAE Biorepository. Dr. Naqash, is an Oncologist with a focus on Early phase clinical trials, drug development and biomarkers in Immunotherapy. He is currently an Assistant professor of Medicine at the Oklahoma Health Stephenson Cancer Center.

    Episode 18: Immune mediated neurological toxicities (Part 2)

    Play Episode Listen Later Dec 19, 2021 39:10


    Learn from the experts about the latest in immune mediated neurological toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- medical Oncologist Dr. Kerry Reynolds, and expert neurologists Drs. Amanda Guidon and Leeann Burton from Massachusetts General Hospital for an informative and high yield discussion.

    Episode 17: Autoimmune Type 1 Diabetes: Challenge for our patients and clinicians

    Play Episode Listen Later Nov 17, 2021 33:54


    Learn from the experts about the clinical diagnosis and multidisciplinary management of autoimmune Type 1 Diabetes. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts and endocrinologists Dr. Ole-Petter Hamnvik and Dr. Le Min from Brigham and Women's Hospital Harvard Medical School and Dana Farber Cancer Institute for an informative and high yield discussion.

    Episode 16: Learning about Immune mediated Adverse events from a trainees persepective

    Play Episode Listen Later Sep 21, 2021 14:58


    Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with resident physicians Dr. Harsh Patolia, Dr. Nathan Hirshman and Dr. Michelle Ferriera who share their experience and tips for fellow residents in training on managing immune mediated adverse events.

    Episode 15: Neuro-toxicities from Immune checkpoint Blockade: Rare and complex (Part 1)

    Play Episode Listen Later Jul 13, 2021 15:23


    Learn from the experts about immune mediated neurological toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Neurologist Dr. Andrew Mammen. Andrew Mammen, M.D., Ph.D., joined NIAMS as Muscle Disease Unit Leader in the Laboratory of Muscle Stem Cells and Gene Regulation in 2014. He obtained his medical degree and Ph.D. in neuroscience at Johns Hopkins in 2000, where he subsequently completed his medicine internship, neurology residency, and neuromuscular fellowship. Prior to his appointment at NIH, he was Associate Professor of Neurology and Medicine at the Johns Hopkins University School of Medicine. He co-founded the Johns Hopkins Myositis Center in 2007, where he continues to see myositis patients as an adjunct faculty member. Dr. Mammen and his colleagues at Hopkins discovered a novel form of autoimmune myopathy associated with statin use and autoantibodies recognizing HMG-CoA reductase, the pharmacologic target of statins. In addition to clinical studies involving myositis patients, his current laboratory research interests include defining pathogenic mechanisms in the various forms of autoimmune myopathy and understanding the role of myositis autoantigens in muscle regeneration.

    Episode 14: Immune Mediated Liver Injury

    Play Episode Listen Later Jun 17, 2021 27:16


    Learn from the experts about the latest in Immune Mediated Liver Toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Transplant Hepatologist Dr. Lindsay King. Dr. King is a Hepatologist, Assistant Professor of Medicine at Duke University School of Medicine.

    Episode 13: Skin Toxicities from Immune Checkpoint Inhibitors (PART 2): Common and perplexing

    Play Episode Listen Later May 26, 2021 17:09


    Hosts: Learn from the experts about the latest in Onco- Dermatology and Immune skin Mediated toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Dermatologist Dr. Adela Rambi Cordones. Dr. Cordones is a Dermatologist, Associate Professor of Dermatology at Duke University School of Medicine. She leads the Immunodermatology Clinic at Duke and is clinician investigator with an expertise in Autoimmune Skin Disease and Cutaneous Drug reactions.

    Episode 12: Skin Toxicities from Immune Checkpoint Inhibitors (PART 1): Common and perplexing

    Play Episode Listen Later May 3, 2021 17:59


    Learn from the experts about the latest in Onco- Dermatology and Immune skin Mediated toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Dermatologist Dr. Meenal Kheterpal. Dr. Kheterpal is a Dermatologist, Assistant Professor of Dermatology at Duke University School of Medicine. She also directs clinical research in Melanoma and Non - Melanoma Skin Cancer at Duke Dermatology.

    Episode 11: Onco-Nephrology and Immune Mediated Nephrotoxicities

    Play Episode Listen Later Apr 12, 2021 42:03


    Learn from the experts about the latest in Onco- Nephrology and Immune Mediated toxicities. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts and Nephrologists Dr. Matt Sparks and Dr. David Ortiz-Melo. Dr. Matt Sparks is a Nephrologist, Assistant Professor of Medicine and the Associate program Director for the Nephrology fellowship at Duke. He is also a well-known online celebrity nephrologist who is the program director of the nephrology social media collective internship and co-creator of Nephmadness. Dr. David Ortiz-Melo is a Nephrologist and Assistant Professor of Medicine. Dr. Ortiz-Melo has created and directs the Onco-Nephrology clinic at Duke.

    Episode 10: Immune Mediated Pulmonary Toxicities

    Play Episode Listen Later Mar 30, 2021 27:13


    Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Oncologist, Dr. Jarushka Naidoo about the complex and challenging diagnosis of Immune mediated Pneumonitis. Dr. Jarushka Naidoo is currently a thoracic oncologist at Beaumont Hospital, Royal College of Surgeons of Ireland and she is also the national lead for lung cancer for Cancer Trials Ireland, and serves as an adjunct professor at Johns Hopkins University. She also serves on the NCCN guidelines committee for the management of immune-related toxicity, and runs an institutional multidisciplinary team for immune toxicity management.

    Episode 9: Immune Mediated Cardiac Toxicities: Diagnostic challenges, management and novel discoveries.

    Play Episode Listen Later Mar 16, 2021 27:03


    Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert Dr. Javid Moslehi, MD, Cardiologist, Associate Professor of Medicine and an expert in immune-mediated cardiotoxicities at Vanderbilt University. Dr. Moslehi is also the Director of Cardio-Oncology at Vanderbilt.

    Episode 8: Immune Mediated Colitis- Novel discoveries and novel therapies

    Play Episode Listen Later Mar 3, 2021 27:10


    Learn from the experts about the latest in scientific trials and novel therapies in the pipeline for management of Immune Mediated Colitis. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- Medical Oncologist- Dr. Kerry Reynolds, Gastroenterologist/ Immunologist- Dr. Micheal Dougan from Massachusetts General Hospital and rising star resident- Dr. Nazli Dizman from Yale for an informative and high yield discussion.

    Episode 7: Immune Mediated Colitis and lessons learnt from multidisciplinary team based management.

    Play Episode Listen Later Feb 16, 2021 32:48


    Learn from the experts about the clinical diagnosis and multidisciplinary management of Immune Mediated Colitis. Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts- medical Oncologist Dr. Kerry Reynolds and Gastroenterologist/ Immunologist Dr. Micheal Dougan from Massachusetts General Hospital for an informative and high yield discussion.

    Episode 6: Rheumatic adverse events: Discussions on biomarkers, collaborations and more.

    Play Episode Listen Later Feb 1, 2021 24:29


    Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest experts and rheumatologists Dr. Leonard Calabrese and Dr. Cassandra Calabrese from Cleveland Clinic and Dr. Alexa Meara from Ohio State University about budding collaborations and scientific discovery in Immune Mediated Rheumatic Adverse Events

    Episode 5: Immune mediated Myositis and Myalgia's: Diagnosis & management for the non-Rheumatologist

    Play Episode Listen Later Jan 18, 2021 16:33


    Hosts: Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Rheumatologist Dr. Sophia Weinmann about the complex and challenging diagnosis of Immune mediated Myositis and Myalgia's.

    Episode 4: Immune mediated Inflammatory Arthritis: Challenges in diagnosis and management

    Play Episode Listen Later Jan 5, 2021 22:30


    Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss with guest expert and Rheumatologist Dr. Sophia Weinmann about the complex and challenging diagnosis of immune mediated Inflammatory Arthritis.

    Episode 3: Breaking down the diagnosis and management of Immune Hypophysitis

    Play Episode Listen Later Dec 8, 2020 19:50


    Join our host Dr. Afreen Shariff and Dr. Tian Zhang as they discuss all things Immune Hypophysitis and what you need to know to get better at managing this complex adverse event.

    Episode 2: Immune Related Thyroid Toxicities

    Play Episode Listen Later Dec 1, 2020 7:58


    Join our hosts Dr. Afreen Shariff and Dr. Tian Zhang as they discuss challenges encountered in the diagnosis and management of commonly encountered Immune related thyroid toxicities.

    Immune Checkpoint Inhibitors have been transformative for cancer care. What have we learnt so far?

    Play Episode Listen Later Nov 24, 2020 10:28


    Hosts- Dr. Afreen Shariff, MD, Endocrinologist, Assistant Professor of Medicine and Dr. Tian Zhang, MD, Genito-Urinary Oncologist, Assistant Professor of Medicine. Duke University Hospital.

    Checkpoint NOW

    Play Episode Listen Later Aug 17, 2020 0:32


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