Podcasts about Massachusetts General Hospital

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Latest podcast episodes about Massachusetts General Hospital

Nightside With Dan Rea
Nightside News Update 6/3/25

Nightside With Dan Rea

Play Episode Listen Later Jun 4, 2025 36:55 Transcription Available


We kicked off the program with four news stories and different guests on the stories we think you need to know about!Rappell Boston - 100 People To Brave The Side of One of Cambridge's Biggest Buildings to Fight Epilepsy on Saturday, June 14, 2025. Josh Drew - Director of Development at Epilepsy Foundation New England and is in charge of the Rappel Event talked with Dan about the event.Boulder, Colorado antisemitic attack that injured a dozen. Adam Katz - president of Foundation to Combat Antisemitism checked in.Is sunscreen toxic? The war on sunscreen! Timothy Rebbeck, a professor of cancer prevention at Dana-Farber Cancer Institute has the answer.At-Home Heart Attacks and Cardiac Deaths on the Rise Since COVID-19 Pandemic, a recent study finds. Dr. Jason Wasfy – author of the published study on this & director of Outcomes Research at the Massachusetts General Hospital Cardiology Division and a faculty member at the Mongan Institute at Massachusetts General Hospital checked in.Listen to WBZ NewsRadio on the NEW iHeart Radio app and be sure to set WBZ NewsRadio as your #1 preset!

ZOE Science & Nutrition
Harvard Doctor: Obesity, cancer, and the real cost of convenience food | Dr. Andy Chan

ZOE Science & Nutrition

Play Episode Listen Later May 29, 2025 51:29


Ultra-processed foods now make up over half of what many of us eat - and the health consequences are only just coming into focus. In this episode, we reveal what's really happening inside your body when you eat these foods daily.  Our guest is Dr. Andy Chan, a Harvard professor and leading expert on gut health and cancer prevention. He heads the Clinical and Translational Epidemiology Unit at Massachusetts General Hospital and has published over 400 scientific papers. Dr. Chan breaks down the hidden links between UPFs, inflammation, and diseases like obesity, diabetes, and colorectal cancer. You'll hear why some foods that look healthy on the shelf may be doing long-term damage - and how the gut microbiome plays a crucial role in the process. This is the research big food companies don't want you to hear. If you care about what you and your family are eating, don't miss this conversation. Unwrap the truth about your food

New England Journal of Medicine Interviews
NEJM Interview: Zirui Song on the rise of concierge and direct primary care practices in the United States.

New England Journal of Medicine Interviews

Play Episode Listen Later May 28, 2025 13:12


Zirui Song is an associate professor of health care policy and medicine at Harvard Medical School and a general internist at Massachusetts General Hospital. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. Z. Song and J.M. Zhu. Primary Care — From Common Good to Free-Market Commodity. N Engl J Med 2025;392:1977-1979.

ForbesBooks Radio
Dr. Marschall Runge's Prescription for Fixing America's Broken Healthcare System

ForbesBooks Radio

Play Episode Listen Later May 27, 2025 38:16


Joe Pardavila welcomes Dr. Marschall Runge, Dean of the University of Michigan Medical School and author of The Great Healthcare Disruption: Big Tech, Bold Policy, and the Future of American Medicine. Dr. Runge shares his bold vision for transforming the U.S. healthcare system, tackling pressing issues like physician burnout, AI-driven innovations, and the challenges of accessibility and affordability.From the potential of AI to streamline administrative tasks and improve patient care to the controversial role of government in healthcare, Dr. Runge doesn't shy away from hard truths. He discusses the obesity epidemic, the promise (and pitfalls) of drugs like Ozempic, and why a blended healthcare system—combining baseline government-provided care with optional private upgrades—could be the key to a healthier America.Whether you're frustrated with long wait times, high costs, or the complexities of modern medicine, this conversation offers fresh perspectives and provocative solutions. Tune in to hear why Dr. Runge believes disruption is exactly what healthcare needs—and how big tech and bold policy could reshape the future of American medicine.Dr. MARSCHALL RUNGE serves as Executive Vice President for Medical Affairs at the University of Michigan, dean of the Medical School, and CEO of Michigan Medicine. With advanced degrees from Vanderbilt and Johns Hopkins, and specialized training at Harvard's Massachusetts General Hospital, he has spent his career driving healthcare innovation and transforming medical education. His insights draw from decades of experience as both a practicing cardiologist and healthcare executive.

Obiettivo Salute
Depressione post-partum: l'Intelligenza Artificiale apre nuove prospettive per la prevenzione

Obiettivo Salute

Play Episode Listen Later May 27, 2025


Analizzando i dati clinici di oltre 29.000 neomamme uno studio condotto dal Massachusetts General Hospital e dalla Harvard Medical School ha sviluppato un modello di Intelligenza Artificiale capace di prevedere il rischio di depressione post-partum. A Obiettivo Salute il commento del prof. Claudio Mencacci, direttore emerito di psichiatria all’ospedale Fatebenefratelli di Milano e co-presidente Sinpf.

Continuum Audio
BONUS EPISODE: Clinical Applications of Artificial Intelligence in Neurology Practice With Dr. Peter Hadar

Continuum Audio

Play Episode Listen Later May 24, 2025 23:45


As artificial intelligence (AI) tools become increasingly mainstream, they can potentially transform neurology clinical practice by improving patient care and reducing clinician workload. Critically evaluating these AI tools for clinical practice is important for successful implementation. In this episode, Katie Grouse, MD, FAAN speaks with Peter Hadar, MD, MS, coauthor of the article “Clinical Applications of Artificial Intelligence in Neurology Practice” in the Continuum® April 2025 Neuro-ophthalmology issue. Dr. Grouse is a Continuum® Audio interviewer and a clinical assistant professor at the University of California San Francisco in San Francisco, California. Dr. Hadar is an instructor of neurology at Harvard Medical School and an attending physician at the Massachusetts General Hospital in Boston, Massachusetts. Additional Resources Read the article: Clinical Applications of Artificial Intelligence in Neurology Practice Subscribe to Continuum®: shop.lww.com/Continuum Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Guest: @PeterNHadar Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about subscribing to the journal, listening to verbatim recordings of the articles, and exclusive access to interviews not featured on the podcast. Dr Grouse: This is Dr Katie Grouse. Today I'm interviewing Dr Peter Hadar about his article on clinical applications of artificial intelligence in neurology practice, which he wrote with Dr Lydia Moura. This article appears in the April 2025 Continuum issue on neuro-ophthalmology. Welcome to the podcast, and please introduce yourself to our audience. Dr Hadar: Hi, thanks for having me on, Katie. My name is Dr Peter Hadar. I'm currently an instructor over at Mass General Hospital, Harvard Medical School, and I'm excited to talk more about AI and how it's going to change our world, hopefully for the better. Dr Grouse: We're so excited to have you. The application of AI in clinical practice is such an exciting and rapidly developing topic, and I'm so pleased to have you here to talk about your article, which I found to be absolutely fascinating. To start, I'd like to hear what you hope will be the key takeaway from your article with our listeners. Dr Hadar: Yeah, thank you. The main point of the article is that AI in medicine is a tool. It's a wonderful tool that we should be cautiously optimistic about. But the important thing is for doctors, providers to be advocates on their behalf and on behalf of their patients for the appropriate use of this tool, because there are promises and pitfalls just with any tool. And I think in the article we detail a couple ways that it can be used in diagnostics, in clinical documentation, in the workflow, all ways that can really help providers. But sometimes the devil is in the details. So, we get into that as well. Dr Grouse: How did you become interested in AI and its application, specifically in the practice of neurology? Dr Hadar: When I was a kid, as most neurologists are, I was- I nerded out on a lot of sci-fi books, and I was really into Isaac Asimov and some of his robotics, which kind of talks about the philosophy of AI and how AI will be integrated in the future. As I got into neurology, I started doing research neurology and a lot of folks, if you're familiar with AI and machine learning, statistics can overlap a lot with machine learning. So slowly but surely, I started using statistical methods, machine learning methods, in some of my neurology research and kind of what brought me to where I am today. Dr Grouse: And thinking about and talking about AI, could you briefly summarize a few important terms that we might be talking about, such as artificial intelligence, generative AI, machine learning, etcetera? Dr Hadar: It's a little difficult, because some of these terms are nebulous and some of these terms are used in the lay public differently than other folks would use it. But in general, artificial intelligence is kind of the ability of machines or computers to communicate independently. It's similar to as humans would do so. And there are kind of different levels of AI. There's this very hard AI where people are worried about with kind of terminator-full ability to replicate a human, effectively. And there are other forms of narrow AI, which are actually more of what we're talking about today, and where it's very kind of specific, task-based applications of machine learning in which even if it's very complex, the AI tools, the machine learning tools are able to give you a result. And just some other terms, I guess out there. You hear a lot about generative AI. There's a lot of these companies and different algorithms that incorporate generative AI, and that usually kind of creates something, kind of from scratch, based on a lot of data. So, it can create pictures, it can create new text if you just ask it. Other terms that can be used are natural language processing, which is a big part of some of the hospital records. When AI tools read hospital records and can summarize something, if it can translate things. So, it turns human speech into these results that you look for. And I guess other terms like large language models are something that also have come into prominence and they rely a lot on natural language processing, being able to understand human speech, interpret it and come up with the results that you want. Dr Grouse: Thank you, that's really helpful. Building on that, what are some of the current clinical applications of AI that we may already be using in our neurologic practice and may not even be aware that that's what that is? Dr Hadar: It depends on which medical record system you use, but a very common one are some of the clinical alerts that people might get, although some of them are pretty basic and they can say, you know, if the sodium is this level, you get an alert. But sometimes they do incorporate fancier machine learning tools to say, here's a red flag. You really should think about contacting the patient about this. And we can talk about it as well. It might encourage burnout with all the different flags. So, it's not a perfect tool. But these sorts of things, typically in the setting of alerts, are the most common use. Sorry, and another one is in folks who do stroke, there are a lot of stroke algorithms with imaging that can help detect where the strokes occur. And that's a heavy machine learning field of image processing, image analysis for rapid detection of stroke. Dr Grouse: That's really interesting. I think my understanding is that AI has been used specifically for radiology interpretation applications for some time now. Is that right? Dr Hadar: In some ways. Actually, my background is in neuroimaging analysis, and we've been doing a lot of it. I've been doing it for years. There's still a lot of room to go, but it's really getting there in some ways. My suspicion is that in the coming years, it's going to be similar to how anesthesiologists at one point were actively bagging people in the fifties, and then you develop machines that can kind of do it for you. At some point there's going to be a prelim radiology read that is not just done by the resident or fellow, but is done by the machine. And then another radiologist would double check it and make sure. And I think that's going to happen in our lifetime. Dr Grouse: Wow, that's absolutely fascinating. What are some potential applications of AI in neurologic practice that may be most high-yield to improve patient care, patient access, and even reduce physician burnout? Dr Hadar: These are separate sort of questions, but they're all sort of interlinked. I think one of the big aspects of patient care in the last few years, especially with the electronic medical record, is patients have become much more their own advocates and we focus a lot more on patient autonomy. So, they are reaching out to providers outside of appointments. This can kind of lead to physician burnout. You have to answer all these messages through the electronic medical record. And so having, effectively, digital twins of yourself, AI version of yourself, that can answer the questions for the patient on your off times is one of the things that can definitely help with patient care. In terms of access, I think another aspect is having integrated workflows. So, being able to schedule patients efficiently, effectively, where more difficult patients automatically get one-hour appointments, patients who have fewer medical difficulties might get shorter appointments. That's another big improvement. Then finally, in terms of physician burnout, having ambient intelligence where notes can be written on your behalf and you just need to double-check them after allows you to really have a much better relationship with the patients. You can actually talk with them one on one and just focus on kind of the holistic care of the patient. And I think that's- being less of a cog in the machine and focusing on your role as a healer would be actually very helpful with the implementation of some of these AI tools. Dr Grouse: You mentioned ambient technology and specifically ambient documentation. And certainly, this is an area that I feel a lot of excitement about from many physicians, a lot of anticipation to be able to have access to this technology. And you mentioned already some of the potential benefits. What are some of the potential… the big wins, but then also potential drawbacks of ambient documentation? Dr Hadar: Just to kind of summarize, the ambient intelligence idea is using kind of an environmental AI system that, without being very obtrusive, just is able to record, able to detect language and process it, usually into notes. So, effectively like an AI scribe that is not actually in the appointment. So, the clear one is that---and I've seen this as well in my practice---it's very difficult to really engage with the patient and truly listen to what they're saying and form that relationship when you're behind a computer and behind a desk. And having that one-on-one interaction where you just focus on the patient, learn everything, and basically someone else takes notes for you is a very helpful component of it. Some of the drawbacks, though, some of it has to do with the existing technology. It's still not at the stage where it can do everything. It can have errors in writing down the medication, writing down the exact doses. It can't really, at this point, detect some of the apprehensions and some of the nonverbal cues that patients and providers may kind of state. Then there's also the big one where a lot of these are still done by startups and other companies where privacy may be an issue, and a lot of patients may feel very uncomfortable with having ambient intelligence tools introduced into their clinical visit, having a machine basically come between the doctor and the patient. But I think that over time these apprehensions will lessen. A lot of the security will improve and be strengthened, and I think that it's going to be incorporated a lot more into clinical practice. Dr Grouse: Yeah, well, we'll all be really excited to see how that technology develops. It certainly seems like it has a lot of promise. You mentioned in your article a lot about how AI can be used to improve screening for patients for certain types of conditions, and that certainly seems like an obvious win. But as I was reading the article, I couldn't help but worry that, at least in the short term, these tools could translate into more work for busy neurologists and more demand for access, which is, you know, already, you know, big problems in our field. How can tools like these, such as, like, for instance, the AI fundoscopic screening for vascular cognitive risk factors help without adding to these existing burdens? Dr Hadar: It's a very good point. And I think it's one of the central points of why we wanted to write the article is that these AI in medicine, it's, it's a tool like any other. And just like when the electronic medical record came into being, a lot of folks thought that this was going to save a lot of time. And you know, some people would say that it actually worsened things in a way. And when you use these diagnostic screening tools, there is an improvement in efficiency, there is an improvement in patient care. But it's important that doctors, patients advocate for this to be value-based and not revenue-based, necessarily. And it doesn't mean that suddenly the appointments are shorter, that now physicians have to see twice as many patients and then patients just have less of a relationship with their provider. So, it's important to just be able to integrate these tools in an appropriate way in which the provider and the patient both benefit. Dr Grouse: You mentioned earlier about the digital twin. Certainly, in your article you mentioned, you know, that idea along with the idea of the potential of development of virtual chatbot visits or in-person visits with a robot neurologist. And I read all this with equal parts, I think excitement, but horror and and fear. Can you tell us more about what these concepts are, and how far are we from seeing technology like this in our clinics, and maybe even, what are the risks we need to be thinking about with these? Dr Hadar: Yeah. So, I mean, I definitely think that we will see implementation of some of these tools in our lifetime. I'm not sure if we're going to have a full walking, talking robot doing some of the clinical visits. But I do think that, especially as we start doing a lot more virtual visits, it is very easy to imagine that there will be some sort of video AI doctor that can serve as, effectively, a digital twin of me or someone else, that can see patients and diagnose them. The idea behind the digital twin is that it's kind of like an AI version of yourself. So, while you only see one patient, an AI twin can go and see two or three other patients. They could also, if the patients send you messages, can respond to those messages in a way that you would, based on your training and that sort of thing. So, it allows for the ability to be in multiple places at once. One of the risks of this is, I guess, overreliance on the technology, where if you just say, we're just going to have a chatbot do everything for us and then not look at the results, you really run the risk of the chatbot just recommending really bad things. And there is training to be had. Maybe in fifty years the chatbot will be at the same level as a physician, but there's still a lot of room for improvement. I personally, I think that my suspicion as to where things will go are for very simple visits in the future and in our lifetime. If someone is having a cold or something like that and it goes to their primary care physician, a chatbot or something like that may be of really beneficial use. And it'll help segment out the different groups of simple diagnosis, simple treatments can be seen by these robots, these AI, these machine learning tools; and some of the more complex ones, at least for the early implementation of this will be seen by more specialized providers like neurologists and subspecialist neurologists too. Dr Grouse: That certainly seems reasonable, and it does seem that the more simple algorithmic things are always where these technologies will start, but it'll be interesting to see where things can go with more complex areas. Now I wanted to switch gears a little bit in the article- and I thought this was really important because I see it as being certainly one of the bigger drawbacks of AI, is that despite the many benefits of artificial intelligence, AI can unfortunately perpetuate systemic bias. And I'm wondering if you could tell us a little bit more about how this happened? Dr Hadar: I know I'm beating a dead horse on this, but AI is a tool like any other. And the problem with it is that what you put in is very similar to what you get out. And there's this idea in computer science of “garbage in, garbage out”. If you include a lot of data that has a lot of systemic biases already in the data, you're going to get results that perpetuate these things. So, for instance, if in dermatologic practices, if you just had a data set that included people of one skin color or one race and you attempted to train a model that would be able to detect skin cancer lesions, that model may not be easily applicable to people of other races, other ethnicities, other skin colors. And that can be very damaging for care. And it can actually really, really hurt the treatments for a lot of the patients. So that is one of the, kind of, main components of the systemic biases in AI. The way we mitigate them is by being aware of it and actually implementing, I guess, really hard stops on a lot of these tools before they get into practice. Being sure, did your data set include this breakdown of sex and gender, of race and ethnicity? So that the stuff you have in the AI tool is not just a very narrow, focused application, but can be generalized to a large population, not just of one community, one ethnic group, racial group, one country, but can really be generalized throughout the world for many patients. Dr Grouse: The first step is being aware of it, and hopefully these models will be built thoughtfully to help mitigate this as much as possible. I wanted to ask as well, another concern about AI is the safety of private data. And I'm wondering, as we're starting to do things like use ambient documentation, AI scribe, and other types of technologies like this, what can we tell our patients who are concerned about the safety of their personal data collected via these programs, particularly when they're being stored or used with outside companies that aren't even in our own electronic medical records system? Dr Hadar: Yeah, it's a very good question, and I think it's one of the major limitations of the current implementation of AI into clinical practice, because we still don't really have great standards---medical standards, at least---for storing this data, how to analyze this data. And my suspicion is that at some point in the future, we're going to need to have a HIPAA compliance that's going to be updated for the 21st century, that will incorporate the appropriate use of these tools, the appropriate use of these data storage, of data storage beyond just PHI. Because there's a lot more that goes into it. I would say that the important thing for how to implement this, and for patients to be aware of, is being very clear and very open with informed consent. If you're using a company that isn't really transparent about their data security and their data sharing practices, that needs to be clearly stated to the patient. If their data is going to be shared with other people, reanalyzed in a different way, many patients will potentially consider not participating in an AI implementation in clinic. And I think the other key thing is that this should be, at least initially, an opt-in approach as opposed to an opt-out approach. So patients really have- can really decide and have an informed opinion about whether or not they want to participate in the AI implementation in medicine. Dr Grouse: Well, thank you so much for explaining that. And it does certainly sound like there's a lot of development that's going to happen in that space as we are learning more about this and the use of it becomes more prevalent. Now, I also wanted to ask, another good point that you made in your article---and I don't think comes up enough in this area, but likely will as we're using it more---AI has a cost, and some of that cost is just the high amount of data and computational processing needed to use it, as well as the effects on the environment from all this energy usage. Given this drawback of AI, how can we think about potential costs versus the benefits, the more widespread use of this technology? Or how should we be thinking about it? Dr Hadar: It's part of a balance of the costs and benefits, effectively, is that AI---and just to kind of name some of them, when you have these larger data centers that are storing all this data, it requires a lot of energy consumption. It requires actually a lot of water to cool these things because they get really hot. So, these are some of the key environmental factors. And at this point, it's not as extreme as it could be, but you can imagine, as the world transitions towards an AI future, these data centers will become huge, massive, require a lot of energy. And as long as we still use a lot of nonrenewable resources to power our world, our civilization, I think this is going to be very difficult. It's going to allow for more carbon in the atmosphere, potentially more climate change. So, being very clear about using sustainable practices for AI usage, whether it be having data centers specifically use renewable resources, have clear water management guidelines, that sort of thing will allow for AI to grow, but in a sustainable way that doesn't damage our planet. In terms of the financial costs… so, AI is not free. However, on a given computer, if you want to run some basic AI analysis, you can definitely do it on any laptop you have and sometimes even on your phone. But for some of these larger models, kind of the ones that we're talking about in the medical field, it really requires a lot of computational power. And this stuff can be very expensive and can get very expensive very quickly, as anyone who's used any of these web service providers can attest to. So, it's very important to be clear-eyed about problems with implementation because some of these costs can be very prohibitive. You can run thousands and you can quickly rack up a lot of money for some very basic analysis if you want to do it in a very rapid way, in a very effective way. Dr Grouse: That's a great overview. You know, something that I think we're all going to be having to think about a lot more as we're incorporating these technologies. So, important conversations I hope we're all having, and in our institutions as we're making these decisions. I wanted to ask, certainly, as some of our listeners who may be still in the training process are hearing you talk about this and are really excited about AI and implementation of technology in medicine, what would you recommend to people who want to pursue a career in this area as you have done? Dr Hadar: So, I think one of the important things for trainees to understand are, there are different ways that they can incorporate AI into their lives going forward as they become more seasoned doctors. There are clinical ways, there are research ways, there are educational ways. A lot of the research ways, I'm one of the researchers, you can definitely incorporate AI. You can learn online. You can learn through books about how to use machine learning tools to do your analysis, and it can be very helpful. But I think one of the things that is lacking is a clinician who can traverse both the AI and patient care fields and be able to introduce AI in a very effective way that really provides value to the patients and improves the care of patients. So that means if a hospital system that a trainee is eventually part of wants to implement ambient technology, it's important for physicians to understand the risks, the benefits, how they may need to adapt to this. And to really advocate and say, just because we have this ambient technology doesn't mean now we see fifty different patients, and then you're stuck with the same issue of a worse patient-provider relationship. One of the reasons I got into medicine was to have that patient-provider interaction to not only be kind of a cog in the hospital machine, but to really take on a role as a healer and a physician. And one of the benefits of these AI tools is that in putting the machine in medicine, you can also put the humanity back in medicine at times. And I think that's a key component that trainees need to take to heart. Dr Grouse: I really appreciate you going into that, and sounds like there's certainly need. Hoping some of our listeners today will consider careers in pursuing AI and other types of technologies in medicine. I really appreciate you coming to talk with us today. I think this is just such a fascinating topic and an area that everybody's really excited about, and hoping that we'll be seeing more of this in our lives and hopefully improving our clinical practice. Thank you so much for talking to us about your article on AI in clinical neurology. It was a fascinating topic and I learned a lot. Dr Hadar: Thank you very much. I really appreciate the conversation, and I hope that trainees, physicians, and others will gain a lot and really help our patients through this. Dr Grouse: So again, today I've been interviewing Dr Peter Hadar about his article on clinical applications of artificial intelligence in neurology practice, which he wrote with Dr Lydia Moura. This article appears in the most recent issue of Continuum on neuro-ophthalmology. Be sure to check out Continuum Audio episodes from this and other issues. And thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. Thank you for listening to Continuum Audio.

Home Base Nation
A "Match" for Life - Two Families, Two Dads, Two Sons - And One US/UK Mission at the Liverpool Football Club

Home Base Nation

Play Episode Listen Later May 23, 2025 25:23


This Episode is dedicated to the memory and honor of the service of Dan Allen and Dominic Snyder.Special Thank You to the Liverpool Football Club and the Royal British Legion for hosting these families."Thank you to the amazing organizations of TAPS, SSAFA, and Home Base for bringing together healed hearts and healed families." - Dustin Snyder.The 2nd Annual Run To Anfield is coming up – AUGUST 2nd, 2025 – So come join us or Run/Walk or support with us virtually anywhere in the world. Especially if you are a Liverpool fan of course.Go to: www.liverpoolfc.com/foundation/run-anfield ______________Run To Home Base: Join Ron and his team and sign up individually or on another team at the 16th annual Run To Home Base on July 26th, 2025, at Fenway Park! Go to runtohomebase.orgPlease go to homebase.org for updates, programming, and resources if you or anyone you know is struggling. Home Base Nation is the official podcast for the Home Base Program for Veterans and Military Families. Our team sees veterans, service members, and their families addressing the invisible wounds of war at no cost. This is all made possible thanks to a grateful nation. If you want to learn more about how to help, visit us at www.homebase.org. If you or anyone you know would like to connect to care, you can also reach us at 617-724-5202.Follow Home Base on Twitter, Facebook, Instagram, LinkedInThe Home Base Nation Team is Steve Monaco, Army Veteran Kelly Field, Justin Scheinert, Chuck Clough, with COO Michael Allard, Brigadier General Jack Hammond, and Peter Smyth.Producer and Host: Dr. Ron HirschbergAssistant Producer, Editor: Chuck CloughChairman, Home Base Media Lab: Peter SmythThe views expressed by guests on the Home Base Nation podcast are their own, and their appearance on the program does not imply an endorsement of them or any entity they represent. Views and opinions expressed by guests are those of the guests and do not necessarily reflect the views of the Massachusetts General Hospital, Home Base, the Red Sox Foundation, or any of its officials.

Moms of Medicine
44. Dr. Suzanne Koven on the importance of writing in medicine, how things have changed for women since she trained and how there's still room for improvement, and so much more!

Moms of Medicine

Play Episode Listen Later May 22, 2025 58:43


"It's really just an extension of the general ethos in medicine which has existed for a very long time – generations, centuries - which says that in order to make other people well we have to make ourselves sick. That is only recently being questioned. "This episode is with Dr. Suzanne Koven who was a primary care physician at Massachusetts General Hospital for over 30 years, has had a prolific literaray career and now serves as the Writer in Residence of Massachusetts General Hospital full time.In this episode we talk about:- Her experience having a baby in residency - Pre-eclampsia- Being asked to write her own maternity leave policy - Her feelings about going part time and what her primary care patients thought about this- What it was like to retire from clinical medicine (spoiler alert - she doesn't miss it)- How she got started in her literary career- The importance of sharing stories- Her book Letter to a Young Female Physician and how that came about- The memoir that she is currently writing Connect with Moms of Medicine:- Instagram @moms_of_medicine- Momsofmedicine@gmail.comConnect with Dr. Suzanne Koven:- Instagram @kovensuzanne

Health Is the Key
Key Note: The Highs and Lows of Blood Pressure

Health Is the Key

Play Episode Listen Later May 21, 2025 3:05


In our May episode, we marked Hypertension Awareness Month with Dr. Robert Ostfeld, a cardiologist at Montefiore Medical Center. Dr. Ostfeld shared how his patients naturally lowered their blood pressure by adopting a plant-based diet and offered tips for eating more plant-based foods. In this month's Key Note, he explains how getting proper sleep can reduce stress hormones that contribute to high blood pressure. The Takeaway We want to hear from you! Please complete our survey: org/member-feedback. Drop us a line at our social media channels: Facebook// Instagram // YouTube. Get started on your health journey by making an appointment with your primary care physician to know your numbers. Get to know your numbers at 1199SEIUBenefits.org/healthyhearts. Find healthy recipes and meal-prep tips at 1199SEIUBenefits.org/food-as-medicine. Visit the Healthy Living Resource Center for wellness tips, information and resources; 1199SEIUBenefits.org/healthyliving. Get inspired by fellow members through our Members' Voices series: 1199SEIUBenefits.org/healthyliving/membervoices. Stop by our Benefits Channel to join webinars on building healthy meals, managing stress and more: 1199SEIUBenefits.org/videos. Visit our YouTube channel to view a wide collection of healthy living videos: youtube.com/@1199SEIUBenefitFunds/playlists. Sample our wellness classes to exercise body and mind: 1199SEIUBenefits.org/wellnessevents. Robert Ostfeld, MD, MSc, FACC, is the Director of Preventive Cardiology at Montefiore Health System and a Professor of Medicine at the Albert Einstein College of Medicine. Dr. Ostfeld treats patients with adult cardiovascular disease, including coronary artery disease, hypertension, hyperlipidemia and erectile dysfunction with a focus on prevention and treatment through lifestyle change. He works closely with his patients to help them adopt a plant-based diet. Dr. Ostfeld received his Bachelor of Arts in the Biologic Basis of Behavior from the University of Pennsylvania, graduating Summa Cum Laude and Phi Beta Kappa and his Doctor of Medicine from Yale University School of Medicine. He then did his medical internship and residency at the Massachusetts General Hospital and his Cardiology Fellowship and Research Fellowship in Preventive Medicine at Brigham and Women's Hospital, both teaching hospitals of Harvard Medical School. During his Cardiology Fellowship, he earned a Master's of Science in Epidemiology from the Harvard School of Public Health. Dr. Ostfeld's research focus is on cardiovascular disease prevention and reversal through lifestyle modification. Ongoing topics he investigates include the impact of plant-based nutrition on erectile function, coronary artery disease, angina and heart failure. His work has been published in peer-reviewed journals, books, articles, and clinical statements and has been presented nationally. Dr. Ostfeld is board certified in Cardiovascular Disease and Echocardiography, and he is a member of numerous professional societies, including the Physician's Committee for Responsible Medicine and the American College of Cardiology.

Home Base Nation
Home Base Nation Top 20: First meet Clinical Social Worker Kate Basile, and the journalist, author and filmmaker Sebastian Junger

Home Base Nation

Play Episode Listen Later May 20, 2025 31:40


We have published 120 episodes since 2019. For this new season, we thought we would look back on some of the highlights of our conversations and choose 20 episodes that resonated with veterans, service members, military families, and the civilians who support them.But first up, you'll hear from some of the folks at Home Base who wake up every day with the same mission in mind, no matter what they do at the Center of Excellence in the Navy Yard and beyond.Over the next twenty weeks, we will share these staff conversations I had with some of the hard-working professionals at Home Base who help treat the invisible wounds of veterans and military families.For this episode, you will hear a brief conversation with Clinical Social Worker Kate Basile, who works in the Intensive Clinical Program at Home Base. This will be followed by our very first episode, in which we sat with journalist, author, and filmmaker Sebastian Junger.Many thanks to Kate Basile for all her work at Home Base in support of this mission to stomp stigma and treat the invisible wounds of veterans and military families.Run To Home Base: Join Ron and his team and sign up individually or on another team at the 16th annual Run To Home Base on July 26th, 2025, at Fenway Park! Go to runtohomebase.orgPlease go to homebase.org for updates, programming, and resources if you or anyone you know is struggling. Home Base Nation is the official podcast for the Home Base Program for Veterans and Military Families. Our team sees veterans, service members, and their families addressing the invisible wounds of war at no cost. This is all made possible thanks to a grateful nation. If you want to learn more about how to help, visit us at www.homebase.org. If you or anyone you know would like to connect to care, you can also reach us at 617-724-5202.Follow Home Base on Twitter, Facebook, Instagram, LinkedInThe Home Base Nation Team is Steve Monaco, Army Veteran Kelly Field, Justin Scheinert, Chuck Clough, with COO Michael Allard, Brigadier General Jack Hammond, and Peter Smyth.Producer and Host: Dr. Ron HirschbergAssistant Producer, Editor: Chuck CloughChairman, Home Base Media Lab: Peter SmythThe views expressed by guests on the Home Base Nation podcast are their own, and their appearance on the program does not imply an endorsement of them or any entity they represent. Views and opinions expressed by guests are those of the guests and do not necessarily reflect the views of the Massachusetts General Hospital, Home Base, the Red Sox Foundation, or any of its officials.

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers
813: Investigating the Impacts of the Gut Microbiome on Immunotherapy Cancer Treatments - Dr. Jennifer Wargo

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Play Episode Listen Later May 19, 2025 35:18


Dr. Jennifer Wargo is an Associate Professor in the Department of Surgical Oncology at The University of Texas MD Anderson Cancer Center and a Stand Up To Cancer researcher. Jennifer is a physician scientist, and this means she splits her time between providing care to patients and doing research to find better ways of treating disease. Specifically, Jennifer performs surgeries and treats patients one day each week. She spends the rest of her week studying how to better treat patients with cancer and how cancer may ultimately be prevented. When she's not doing research or treating patients, Jennifer enjoys spending quality time with her family. Some of their favorite activities include going for walks, biking, hiking, and visiting the beach. Jennifer also likes to explore her creative side through art and photography, as well as to be active through running, biking, yoga, and surfing. She received her A.S. degree in nursing and B.S. degree in biology from Gwynedd-Mercy College. Afterwards, Jennifer attended the Medical College of Pennsylvania where she earned her M.D. Jennifer completed her Clinical Internship and Residency in General Surgery at Massachusetts General Hospital. Next, Jennifer was a Research Fellow in Surgical Oncology at the University of California, Los Angeles. She then accepted a Clinical Residency in General Surgery at Massachusetts General Hospital. From 2006-2008, Jennifer was a Clinical Fellow in Surgical Oncology at the National Cancer Institute of the National Institutes of Health. She then served on the faculty at Massachusetts General Hospital and Harvard University. In 2012, Jennifer received her MMSc. degree in Medical Science from Harvard University. Jennifer joined the faculty at The University of Texas MD Anderson Cancer Center in 2013. She is Board Certified by the American Board of Surgery, and she has received numerous awards and honors throughout her career. These have included the R. Lee Clark Prize and Best Boss Award from the MD Anderson Cancer Center, the Rising STARS and The Regents' Health Research Scholars Awards from the University of Texas System, the Outstanding Young Investigator and Outstanding Investigator Awards from the Society for Melanoma Research, as well as a Stand Up To Cancer Innovative Research Grant for her microbiome work. She has also received other awards for excellence in teaching, research, and patient care. In our interview, Jennifer shares more about her life and science.

The John Fugelsang Podcast
A Golden Plane for a Golden Calf with a Golden Spray Tan

The John Fugelsang Podcast

Play Episode Listen Later May 14, 2025 103:11


John's monologue first discusses Jake Tapper's new book "Original Sin" which blames White House staffers and the media for covering up President Biden's supposed cognitive decline. He also talks about Trump in Saudi Arabia, where he met with Arab business leaders, hoping to land the next great freebie. He also announced an imminent cessation of sanctions on Syria, a major policy shift encouraged by both Saudi Arabia and Turkey. Then, Professor Corey Brettschneider returns to debate about Supreme Court Justice John Roberts' weak Trump rebuke, whether a president can suspend habeas corpus, and birthright citizenship which is now heading to the Supreme Court. Next, John interviews Dr. Anahita Dua - who is an Assistant Professor at Harvard Medical School and a vascular surgeon at the Massachusetts General Hospital. They talk about Trump's choice for Surgeon General: Right-Wing wellness Influencer Casey Means. And then finally, comedian Keith Price is back to joke with listeners about the latest trends and the firehose of dumpster fire news coming from the GOP and "Man-Baby".See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Home Base Nation
Home Base Nation Top 20: First meet Home Base Marine Veteran Alexander Hohl, Licensed Mental Health Counselor, and the Dr. David King and David "Big Papi" Ortiz episode

Home Base Nation

Play Episode Listen Later May 13, 2025 42:25


We have published 120 episodes since 2019. For this new season, we thought we would look back on some of the highlights of our conversations and choose 20 episodes that resonated with veterans, service members, military families, and the civilians who support them.But first up, you'll hear from some of the folks at Home Base who wake up every day with the same mission in mind, no matter what they do at the Center of Excellence in the Navy Yard and beyond.Over the next twenty weeks, we will share these staff conversations I had with some of the hard-working professionals at Home Base who help treat the invisible wounds of veterans and military families.For this episode, you will hear a brief conversation with Home Base Marine Veteran Alexander Hohl, Licensed Mental Health Counselor, followed by one of the earlier episodes, in which Ron sat with the US Army Colonel and Combat Surgeon Dr. David King and Red Sox legend David "Big Papi" Ortiz.  Boston just celebrated the 250th anniversary of the American Revolution, and we felt it a good time to re-share the episode that remembers the Boston Marathon bombing and the inspiration Big Papi brought to the city during that time.Many thanks to Alexander Hohl for all his work at Home Base to support this mission to stomp stigma and treat the invisible wounds of veterans and military families.Run To Home Base: Join Ron and his team and sign up individually or on another team at the 16th annual Run To Home Base on July 26th, 2025, at Fenway Park! Go to runtohomebase.orgPlease go to homebase.org for updates, programming, and resources if you or anyone you know is struggling. Home Base Nation is the official podcast for the Home Base Program for Veterans and Military Families. Our team sees veterans, service members, and their families addressing the invisible wounds of war at no cost. This is all made possible thanks to a grateful nation. If you want to learn more about how you can help, visit us at www.homebase.org. If you or anyone you know would like to connect to care, you can also reach us at 617-724-5202.Follow Home Base on Twitter, Facebook, Instagram, LinkedInThe Home Base Nation Team is Steve Monaco, Army Veteran Kelly Field, Justin Scheinert, Chuck Clough, with COO Michael Allard, Brigadier General Jack Hammond, and Peter Smyth.Producer and Host: Dr. Ron HirschbergAssistant Producer, Editor: Chuck CloughChairman, Home Base Media Lab: Peter SmythThe views expressed by guests on the Home Base Nation podcast are their own, and their appearance on the program does not imply an endorsement of them or any entity they represent. Views and opinions expressed by guests are those of the guests and do not necessarily reflect the views of the Massachusetts General Hospital, Home Base, the Red Sox Foundation, or any of its officials.

The Revitalizing Doctor
The Masked Hero: Empowering Children to Embrace Diversity and Celebrate Heroes - Dr. Shan Liu

The Revitalizing Doctor

Play Episode Listen Later May 13, 2025 43:05


In this Heartline Echo Episode, Dr. Shan Liu, a physician and children's book author shares her journey of writing ⁠The Masked Hero⁠. Inspired by her great-grandfather's invention of a face mask to combat the Manchurian plague, Dr. Liu illustrates how heroes come from diverse backgrounds. Join us in this week's episode to learn of how Dr. Liu went from feeling defeated during the worst moments of the pandemic, including when hate crimes and discrimination against Asian Americans peaked, to discovering her voice and a way to connect with her daughter by writing ⁠The Masked Hero⁠. "I wanted to, as a mom, somehow impact my kids in a way that would make them proud of their ancestry and who they are." - Dr. Shan Liu Dr. Shan Liu, an emergency medicine physician at Massachusetts General Hospital and an associate professor at Harvard Medical School, is our special guest on today's episode. With a passion for storytelling and a desire to promote diversity and inclusivity, Dr. Liu recently made her publishing debut with the children's book, The Masked Hero. Inspired by her great-grandfather's work in public health and medicine in China, Dr. Liu aims to help children understand that heroes come from all backgrounds.

Mom & Mind
415: An Inside Look at the ”So Glad You Asked” Podcast with Dr. Ruta Nonacs and Allie Hales

Mom & Mind

Play Episode Listen Later May 12, 2025 50:47


We just celebrated Mother's Day, which may not have been what you expected. It can be a complicated day when people don't show up or recognize you as you deserve. I want to acknowledge the complex feelings that come with Mother's Day and say that you aren't alone in experiencing those emotions. Whatever your Mother's Day brought you, I hope you feel recognized and supported. Today, we are bringing you another great episode during Maternal Mental Health Month as we uncover the purpose of a new podcast filling a gap for many people. Join us to learn more about this vital resource! Allie Hales, a mom of four, is passionate about making reliable, relevant information available for moms like herself. She graduated from the J. Reuben Clark Law School at Brigham Young University and is a member of the Massachusetts Bar. She serves on Brigham and Women's Hospital's Newborn Medicine and Reproductive Health Advisory Board, Newton-Wellesley Hospital's Maternal Services Council, and is actively involved with the Boston Center for Endometriosis. Allie grew up in the suburbs of Boston and currently lives in Baltimore with her four children and her husband, Riley, a resident in anesthesia at Johns Hopkins Hospital.  Dr. Ruta Nonacs completed a perinatal and reproductive psychiatry fellowship at Massachusetts General Hospital. She is a clinical instructor at Harvard Medical School, a senior psychiatrist with the Center for Women's Mental Health at Massachusetts General Hospital, and the creator and editor-in-chief of their website,⁠ ⁠⁠womensmentalhealth.org⁠. She, with Allie Hales, co-hosts the new podcast,⁠ So Glad You Asked⁠. Dr. Ruta's work has been published in numerous scientific journals and books, and she is the author of⁠ A Deeper Shade of Blue: A Woman's Guide to Recognizing and Treating Depression in Her Childbearing Years. ⁠ Show Highlights: Highlights of Dr. Ruta's path to her current work Allie's lived experience in her mental health journey and her connection to Dr. Ruta Barriers to getting information and accessing treatment The importance of lived experience in developing solutions and strategies Moms, questions, and a new podcast Giving a voice to “regular moms” and providing evidence-based solutions Major topics planned for upcoming podcast episodes (Dr. Ruta and Allie have a huge list!) The connection between the podcast and a resource hub at ⁠womensmentalhealth.org⁠ Accessible information IS preventative. The podcast schedule and plans for the first season Dr. Ruta and Allie's hopes and dreams for their podcast to empower and support women Resources: Connect with Dr. Ruta Nonacs and Allie Hales:⁠ Women's Mental Health website⁠,⁠ Instagram⁠,⁠ So Glad You Asked⁠ podcast, and⁠ A Deeper Shade of Blue: A Woman's Guide to Recognizing and Treating Depression in Her Childbearing Years⁠. Call the National Maternal Mental Health Hotline at 1-833-TLC-MAMA or visit⁠ cdph.ca.gov⁠ Please find resources in English and Spanish at⁠ Postpartum Support International⁠, or by phone/text at 1-800-944-4773. There are many free resources, like online support groups, peer mentors, a specialist provider directory, and perinatal mental health training for therapists, physicians, nurses, doulas, and anyone who wants to be more supportive in offering services.  You can also follow PSI on social media:⁠ Instagram⁠,⁠ Facebook⁠, and most other platforms Visit⁠ www.postpartum.net/professionals/certificate-trainings/⁠ for information on the grief course.   Visit my website,⁠ www.wellmindperinatal.com⁠, for more information, resources, and courses you can take today! If you are a California resident looking for a therapist in perinatal mental health, ⁠email me⁠ about openings for private pay clients! Learn more about your ad choices. Visit podcastchoices.com/adchoices

ASCO eLearning Weekly Podcasts
Incorporating Integrative Oncology Into Practice for GI Cancers and Beyond

ASCO eLearning Weekly Podcasts

Play Episode Listen Later May 12, 2025 30:04


Host Dr. Nate Pennell and his guest, Dr. Chloe Atreya, discuss the ASCO Educational Book article, “Integrative Oncology: Incorporating Evidence-Based Approaches to Patients With GI Cancers,” highlighting the use of mind-body approaches, exercise, nutrition, acupuncture/acupressure, and natural products. Transcript Dr. Nate Pennell: Welcome to ASCO Education: By the Book, our new monthly podcast series that will feature engaging discussions between editors and authors from the ASCO Educational Book. We'll be bringing you compelling insights on key topics featured in Education Sessions at ASCO meetings and some deep dives on the approaches shaping modern oncology.  I'm Dr. Nate Pennell, director of the Cleveland Clinic Lung Cancer Medical Oncology Program as well as vice chair of clinical research for the Taussig Cancer Institute. Today, I'm delighted to welcome Dr. Chloe Atreya, a professor of Medicine in the GI Oncology Group at the University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, and the UCSF Osher Center for Integrative Health, to discuss her article titled, “Integrative Oncology Incorporating Evidence-Based Approaches to Patients With GI Cancers”, which was recently published in the ASCO Educational Book. Our full disclosures are available in the transcript of this episode.  Dr. Atreya, it's great to have you on the podcast today. Thanks for joining me. Dr. Chloe Atreya: Thanks Dr. Pennell. It's a pleasure to be here. Dr. Nate Pennell: Dr. Atreya, you co-direct the UCSF Integrative Oncology Program with a goal to really help patients with cancer live as well as possible. And before we dive into the review article and guidelines, I'd love to just know a little bit about what inspired you to go into this field? Dr. Chloe Atreya: Yeah, thank you for asking. I've had a long-standing interest in different approaches to medicine from global traditions and I have a degree in pharmacology, and I continue to work on new drug therapies for patients with colorectal cancer. And one thing that I found is that developing new drugs is a long-term process and often we're not able to get the drugs to the patients in front of us. And so early on as a new faculty member at UCSF, I was trying to figure out what I could do for the patient in front of me if those new drug therapies may not be available in their lifetime. And one thing I recognized was that in some conversations the patient and their family members, even if the patient had metastatic disease, they were able to stay very present and to live well without being sidelined by what might happen in the future. And then in other encounters, people were so afraid of what might be happening in the future, or they may have regrets maybe about not getting that colonoscopy and that was eroding their ability to live well in the present.  So, I started asking the patients and family members who were able to stay present, “What's your secret? How do you do this?” And people would tell me, “It's my meditation practice,” or “It's my yoga practice.” And so, I became interested in this. And an entry point for me, and an entry point to the Osher Center at UCSF was that I took the Mindfulness-Based Stress Reduction Program to try to understand experientially the evidence for this and became very interested in it. I never thought I would be facilitating meditation for patients, but it became a growing interest. And as people are living longer with cancer and are being diagnosed at younger ages, often with young families, how one lives with cancer is becoming increasingly important.   Dr. Nate Pennell: I've always been very aware that it seemed like the patients that I treated who had the best quality of life during their life with cancer, however that ended up going, were those who were able to sort of compartmentalize it, where, when it was time to focus on discussing treatment or their scans, they were, you know, of course, had anxiety and other things that went along with that. But when they weren't in that, they were able to go back to their lives and kind of not think about cancer all the time. Whereas other people sort of adopt that as their identity almost is that they are living with cancer and that kind of consumes all of their time in between visits and really impacts how they're able to enjoy the rest of their lives. And so, I was really interested when I was reading your paper about how mindfulness seemed to be sort of like a formal way to help patients achieve that split. I'm really happy that we're able to talk about that. Dr. Chloe Atreya: Yeah, I think that's absolutely right. So, each of our patients is more than their cancer diagnosis. And the other thing I would say is that sometimes patients can use the cancer diagnosis to get to, “What is it that I really care about in life?” And that can actually heighten an experience of appreciation for the small things in life, appreciation for the people that they love, and that can have an impact beyond their lifetime. Dr. Nate Pennell: Just in general, I feel like integrative medicine has come a long way, especially over the last decade or so. So, there's now mature data supporting the incorporation of elements of integrative oncology into comprehensive cancer care. We've got collaborations with ASCO. They've published clinical practice guidelines around diet, around exercise, and around the use of cannabinoids. ASCO has worked with the Society for Integrative Oncology to address management of pain, anxiety, depression, fatigue – lots of different evidence bases now to try to help guide people, because this is certainly something our patients are incredibly interested in learning about. Can you get our listeners up to speed a little bit on the updated guidelines and resources supporting integrative oncology? Dr. Chloe Atreya: Sure. I can give a summary of some of the key findings. And these are rigorous guidelines that came together by consensus from expert panels. I had the honor of serving on the anxiety and depression panel. So, these panels will rate the quality of the evidence available to come up with a strength of recommendation. I think that people are at least superficially aware of the importance of diet and physical activity and that cannabis and cannabinoids have evidence of benefit for nausea and vomiting. They may not be aware of some of the evidence supporting these other modalities. So, for anxiety and depression, mindfulness-based interventions, which include meditation and meditative movement, have the strongest level of evidence. And the clinical practice guidelines indicate that they should be offered to any adult patient during or after treatment who is experiencing symptoms of anxiety or depression. Other modalities that can help with anxiety and depression include yoga and Tai Chi or Qigong. And with the fatigue guidelines, mindfulness-based interventions are also strongly recommended, along with exercise and cognitive behavioral therapy, Tai Chi and Qigong during treatment, yoga after treatment.  And some of these recommendations also will depend on where the evidence is. So, yoga is an example of an intervention that I think can be helpful during treatment, but most of our evidence is on patients who are post-treatment. So, most of our guidelines separate out during treatment and the post-treatment phase because the quality of evidence may be different for these different phases of treatment.  With the pain guidelines, the strongest recommendation is for acupuncture, specifically for people with breast cancer who may be experiencing joint pain related to aromatase inhibitors. However, acupuncture and other therapies, including massage, can be helpful with pain as well. So those are a few of the highlights. Dr. Nate Pennell: Yeah, I was surprised at the really good level of evidence for the mindfulness-based practices because I don't think that's the first thing that jumps to mind when I think about integrative oncology. I tend to think more about physical interventions like acupuncture or supplements or whatnot. So, I think this is really fantastic that we're highlighting this.  And a lot of these interventions like the Qigong, Tai Chi, yoga, is it the physical practice of those that benefits them or is it that it gives them something to focus on, to be mindful of? Is that the most important intervention? It doesn't really matter what you're doing as long as you have something that kind of takes you out of your experience and allows you to focus on the moment. Dr. Chloe Atreya: I do think it is a mind, body and spirit integration, so that all aspects are important. We also say that the best practice is the one that you actually practice. So, part of the reason that it's important to have these different modalities is that not everybody is going to take up meditation. And there may be people for whom stationary meditation, sitting and meditating, works well, and other people for whom meditative movement practices may be what they gravitate to. And so, I think that it's important to have a variety of options. And one thing that's distinct from some of our pharmacologic therapies is that the safety of these is, you know, quite good. So, it becomes less important to say, “Overall, is Tai Chi better or is yoga better?” for instance. It really depends on what it is that someone is going to take up. Dr. Nate Pennell: And of course, something that's been really nice evidence-based for a long time, even back when I was in my training in the 2000s with Jennifer Temel at Massachusetts General Hospital, was the impact of physical activity and exercise on patients with cancer. It seems like that is pretty much a universally good recommendation for patients. Dr. Chloe Atreya: Yes, that's absolutely right. Physical activity has been associated with improved survival after a cancer diagnosis. And that's both cancer specific survival and overall survival.  The other thing I'll say about physical activity, especially the mindful movement practices like Tai Chi and Qigong and yoga, is that they induce physiologic shifts in the body that can promote relaxation, so they can dampen that stress response in a physiologic way. And these movement practices are also the best way to reduce cancer-associated fatigue. Dr. Nate Pennell: One of the things that patients are always very curious about when they talk to me, and I never really feel like I'm as well qualified as I'd like to be to advise them around dietary changes in nutrition. And can you take me a little bit through some of the evidence base for what works and what doesn't work? Dr. Chloe Atreya: Sure. I do think that it needs to be tailored to the patient's needs. Overall, a diet that is plant-based and includes whole grains is really important. And I often tell patients to eat the rainbow because all of those different phytochemicals that cause the different colors in our fruits and vegetables are supporting different gut microbiota. So that is a basis for a healthy gut microbiome. That said, you know, if someone is experiencing symptoms related to cancer or cancer therapy, it is important to tailor dietary approaches. This is where some of the mindful eating practices can help. So, sometimes actually not just focusing on what we eat, but how we eat can help with symptoms that are associated with eating. So, some of our patients have loss of appetite, and shifting one's relationship to food can help with nutrition. Sometimes ‘slow it down' practices can help both with appetite and with digestion. Dr. Nate Pennell: One of the things that you said both in the paper and just now on our podcast, talking about how individualized and personalized this is. And I really liked the emphasis that you had on flexibility and self-compassion over rigid discipline and prescriptive recommendations here. And this is perhaps one of the real benefits of having an integrative oncology team that can work with patients as opposed to them just trying to find things online. Dr. Chloe Atreya: Yes, particularly during treatment, I think that's really important. And that was borne out by our early studies we called “Being Present.” So, after I was observing the benefits anecdotally among my patients of the ability to be present, we designed these pilot studies to teach meditation and meditative practices to patients. And in these pilot studies, the original ones were pretty prescriptive in a way that mindfulness-based stress reduction is fairly prescriptive in terms of like, “This is what we're asking you to do. Just stick with the program.” And there can be benefits if you can stick with the program. It's really hard though if someone is going through treatment and with GI cancers, it may be that they're getting chemotherapy every two weeks and they have one week where they're feeling really crummy and another week where they're trying to get things done. And we realized that sometimes people were getting overwhelmed and feeling like the mindfulness practice was another thing on their to-do list and that they were failing if they didn't do this thing that was important for them. And so, we've really kind of changed our emphasis. And part of our emphasis now is on incorporating mindfulness practices into daily life. Any activity that doesn't require a lot of executive function can be done mindfully, meaning with full attention. And so, especially for some of our very busy patients, that can be a way of, again, shifting how I'm doing things rather than adding a new thing to do. Dr. Nate Pennell: And then another part I know that patients are always very curious about that I'm really happy to see that we're starting to build an evidence base for is the use of supplements and natural products. So, can you take us a little bit through where we stand in terms of evidence behind, say, cannabis and some of the other available products out there? Dr. Chloe Atreya: Yeah, I would say that is an area that requires a lot more study. It's pretty complicated because unlike mindfulness practices where there are few interactions with other treatments, there is the potential for interactions, particularly with the supplements. And the quality of the supplements matters. And then there tends to be a lot of heterogeneity among the studies both in the patients and what other treatments they may be receiving, as well as the doses of the supplements that they're receiving.  One of my earliest mentors at Yale is someone named Dr. Tommy Chang, who has applied the same rigor that that we apply to testing of biomedical compounds to traditional Chinese medicine formulas. And so, ensuring that the formulation is stable and then formally testing these formulations along with chemotherapy. And we need more funding for that type of research in order to really elevate our knowledge of these natural products. We often will direct patients to the Memorial Sloan Kettering ‘About Herbs, Botanicals, and Other Products' database as one accessible source to learn more about the supplements. We also work with our pharmacists who can provide the data that exists, but we do need to take it with a grain of salt because of the heterogeneity in the data. And then it's really important if people are going to take supplements, for them to take supplements that are of high quality. And that's something in the article that we list all of the things that one should look for on the label of a supplement to ensure that it is what it's billed to be. Dr. Nate Pennell: So, most of what we've been talking about so far has really been applying to all patients with cancer, but you of course are a GI medical oncologist, and this is a publication in the Educational Book from the ASCO GI Symposium. GI cancers obviously have an incredibly high and rising incidence rate among people under 50, representing a quarter of all cancer incidence worldwide, a third of cancer related deaths worldwide. Is there something specific that GI oncologists and patients with GI cancers can take home from your paper or is this applicable to pretty much everyone? Dr. Chloe Atreya: Yeah, so the evidence that we review is specifically for GI cancers. So, it shows both its strengths and also some of the limitations. So many of the studies have focused on other cancers, especially breast cancer. In the integrative oncology field, there are definitely gaps in studying GI cancers. At the same time, I would say that GI cancers are very much linked to lifestyle in ways that are complicated, and we don't fully understand. However, the best ways that we can protect against development of GI cancers, acknowledging that no one is to blame for developing a GI cancer and no one is fully protected, but the best things that we can do for overall health and to prevent GI cancers are a diet that is plant-based, has whole grains. There's some data about fish that especially the deep-water fish, may be protective and then engaging in physical activity.  One thing I would like for people to take away is that these things that we know that are preventative against developing cancer are also important after development of a GI cancer. Most of the data comes from studies of patients with colorectal cancer and that again, both cancer specific and overall mortality is improved with better diet and with physical activity. So, this is even after a cancer diagnosis. And I also think that, and this is hard to really prove, but we're in a pretty inflammatory environment right now. So, the things that we can do to decrease stress, improve sleep, decrease inflammation in the body, and we do know that inflammation is a risk factor for developing GI cancers. So, I think that all of the integrative modalities are important both for prevention and after diagnosis. Dr. Nate Pennell: And one of the things you just mentioned is that most of the studies looking at integrative oncology and GI cancers have focused on colorectal cancer, which of course, is the most common GI cancer. But you also have pointed out that there are gaps in research and what's going on and what needs to be done in order to broaden some of this experience to other GI cancers. Dr. Chloe Atreya: Yeah, and I will say that there are gaps even for colorectal cancer. So right now, some of the authors on the article are collaborating on a textbook chapter for the Society for Integrative Oncology. And so, we're again examining the evidence specifically for colorectal cancer and are in agreement that the level of evidence specific to colorectal cancer is not as high as it is for all patients with adult cancers. And so even colorectal cancer we need to study more.  Just as there are different phases of cancer where treatments may need to be tailored, we also may need to tailor our treatments for different cancer types. And that includes what symptoms the patients are commonly experiencing and how intense the treatment is, and also the duration of treatment. Those are factors that can influence which modalities may be most important or most applicable to a given individual. Dr. Nate Pennell: So, a lot of this sounds fantastic. It sounds like things that a lot of patients would really appreciate working into their care. Your article focused a little bit on some of the logistics of providing this type of care, including group medical visits, multidisciplinary clinics staffed by multiple types of clinicians, including APPs and psychologists, and talked about the sustainability of this in terms of increasing the uptake of guideline-based integrative oncology. Talk a little bit more about both at your institution, I guess, and the overall health system and how this might be both sustainable and perhaps how we broaden this out to patients outside of places like UCSF. Dr. Chloe Atreya: Yes, that's a major focus of our research effort. A lot of comprehensive cancer centers and other places where patients are receiving care, people may have access to dietitians, which is really important and nutritionists. In the article we also provide resources for working with exercise therapists and those are people who may be working remotely and can help people, for instance, who may be in, in rural areas. And then our focus with the mind-body practices in particular has been on group medical visits. And this grew out of, again, my ‘being present' pilot studies where we were showing some benefit. But then when the grant ends, there isn't a way to continue to deliver this care. And so, we were asking ourselves, you know, is there a way to make this sustainable? And group medical visits have been used in other settings, and they've been working really well at our institution and other institutions are now taking them up as well. And this is a way that in this case it's me and many of my colleagues who are delivering these, where I can see eight or ten patients at once. In my case, it's a series of four two-hour sessions delivered by telehealth. So, we're able to focus on the integrative practices in a way that's experiential. So, in the clinic I may be able to mention, you know, after we go over the CT scans, after we go over the labs and the molecular profiling, you know, may be able to say, “Hey, you know, meditation may be helpful for your anxiety,” but in the group medical visits we can actually practice meditation, we can practice chair yoga. And that's where people have that experience in their bodies of these different modalities. And the feedback that we're receiving is that that sticks much more to experience it then you have resources to continue it. And then the group is helpful both in terms of delivery, so timely and efficient care for patients. It's also building community and reducing the social isolation that many of our patients undergoing treatment for cancer experience. Dr. Nate Pennell: I think that makes perfect sense, and I'm glad you brought up telehealth as an option. I don't know how many trained integrative oncologists there are out there, but I'm going to guess this is not a huge number out there. And much like other specialties that really can improve patients' quality of life, like palliative medicine, for example, not everyone has access to a trained expert in their cancer center, and things like telemedicine and telehealth can really potentially broaden that. How do you think telehealth could help broaden the exposure of cancer patients and even practitioners of oncology to integrative medicine? Dr. Chloe Atreya: Yes, I think that telehealth is crucial for all patients with cancer to be able to receive comprehensive cancer care, no matter where they're receiving their chemotherapy or other cancer-directed treatments. So, we will routinely be including patients who live outside of San Francisco. Most of our patients live outside of San Francisco. There's no way that they could participate if they had to drive into the city again to access this. And in the group setting, it's not even safe for people who are receiving chemotherapy to meet in a group most times. And with symptoms, often people aren't feeling so well and they're able to join us on Zoom in a way that they wouldn't be able to make the visit if it was in person. And so, this has really allowed us to expand our catchment area and to include patients, in our case, in all of California. You also mentioned training, and that's also important. So, as someone who's involved in the [UCSF] Osher Collaborative, there are faculty scholars who are at universities all over the US, so I've been able to start training some of those physicians to deliver group medical visits at their sites as well via telehealth. Dr. Nate Pennell: I'm glad we were able to make a plug for that. We need our political leadership to continue to support reimbursement for telehealth because it really does bring access to so many important elements of health care to patients who really struggle to travel to tertiary care centers. And their local cancer center can be quite a distance away.  So, sticking to the theme of training, clinician education and resources are really crucial to continue to support the uptake of integrative oncology in comprehensive cancer care. Where do you think things stand today in terms of clinician education and professional development in integrative oncology. Dr. Chloe Atreya: It's growing. Our medical students now are receiving training in integrative medicine, and making a plug for the Educational Book, I was really happy that ASCO let us have a table that's full of hyperlinks. So that's not typical for an article. Usually, you have to go to the reference list, but I really wanted to make it practical and accessible to people, both the resources that can be shared with patients that are curated and selected that we thought were of high-quality examples for patients. At the bottom of that table also are training resources for clinicians, and some of those include: The Center for Mind-Body Medicine, where people can receive training in how to teach these mind-body practices; The Integrated Center for Group Medical Visits, where people can learn how to develop their own group medical visits; of course, there's the Society for Integrative Oncology; and then I had just mentioned the Osher Collaborative Faculty Fellowship. Dr. Nate Pennell: Oh, that is fantastic. And just looking through, I mean, this article is really a fantastic resource both of the evidence base behind all of the elements that we've discussed today. Actually, the table that you mentioned with all of the direct hyperlinks to the resources is fantastic. Even recommendations for specific dietary changes after GI cancer diagnosis. So, I highly recommend everyone read the full paper after they have listened to the podcast today.  Before we wrap up, is there anything that we didn't get a chance to discuss that you wanted to make sure our listeners are aware of? Dr. Chloe Atreya: One thing that I did want to bring up is the disparities that exist in access to high quality symptom management care. So, patients who are racial and ethnic minorities, particularly our black and Latinx patients, the evidence shows that they aren't receiving the same degree of symptom management care as non-Hispanic White patients. And that is part of what may be leading to some of the disparities in cancer outcomes. So, if symptoms are poorly managed, it's harder for patients to stay with the treatment, and integrative oncology is one way to try to, especially with telehealth, this is a way to try to improve symptom management for all of our patients to help improve both their quality of life and their cancer outcomes. Dr. Nate Pennell: Well, Dr. Atreya, it's been great speaking with you today and thank you for joining me on the ASCO Education: By the Book Podcast and thank you for all of your work in advancing integrative oncology for GI cancers and beyond. Dr. Chloe Atreya: Thank you, Dr. Pennell. It's been a pleasure speaking with you. Dr. Nate Pennell: And thank you to all of our listeners who joined us today. You'll find a link to the article discussed today in the transcript of the episode. We hope you'll join us again for more insightful views on topics you'll be hearing at the Education Sessions from ASCO meetings throughout the year and our deep dives on approaches that are shaping modern oncology. Disclaimer: The purpose of this podcast is to educate, educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:    Dr. Nathan Pennell   @n8pennell  @n8pennell.bsky.social  Dr. Chloe Atreya  Follow ASCO on social media:    @ASCO on X (formerly Twitter)    ASCO on Bluesky   ASCO on Facebook    ASCO on LinkedIn    Disclosures:   Dr. Nate Pennell:       Consulting or Advisory Role: AstraZeneca, Lilly, Cota Healthcare, Merck, Bristol-Myers Squibb, Genentech, Amgen, G1 Therapeutics, Pfizer, Boehringer Ingelheim, Viosera, Xencor, Mirati Therapeutics, Janssen Oncology, Sanofi/Regeneron      Research Funding (Institution): Genentech, AstraZeneca, Merck, Loxo, Altor BioScience, Spectrum Pharmaceuticals, Bristol-Myers Squibb, Jounce Therapeutics, Mirati Therapeutics, Heat Biologics, WindMIL, Sanofi   Dr. Chloe Atreya: Consulting or Advisory Role: Roche Genentech, Agenus Research Funding (Institution): Novartis, Merck, Bristol-Myers Squibb, Guardant Health, Gossamer Bio, Erasca, Inc.

The Cowboy Up Podcast
SE544 Meet Dr. Allen Hamilton ... a cowboy doctor and one of the most extraordinary persons we have ever met. Now you need to meet him and hear from him too!

The Cowboy Up Podcast

Play Episode Listen Later May 10, 2025 46:14


Allan Hamilton started as a janitor and eventually went on to graduate from Harvard Medical School and complete his neurosurgical residency training at the Massachusetts General Hospital in Boston. Dr. Hamilton currently holds four Professorships at the University of Arizona. He is a tenured professor of neurosurgery, as well as professorships in radiation oncology, psychology, and electrical and computer engineering. In 2019, Dr. Hamilton was inducted as Regents' Professor of Surgery. Dr. Hamilton has held positions as both the Chief of the Division of Neurosurgery and Chairman of the Department of Surgery at the University of Arizona and is also a decorated Army officer who served in Operation Desert Storm. An author of more than twenty medical textbook chapters, nearly one hundred peer-review research articles, and has served on the editorial board of several medical journals and for the last several years he has served as Senior Medical Script Consultant for the television series, Grey's Anatomy, and four seasons of Private Practice. He continues to consult in Hollywood and most recently worked as a consultant for Peter Berg's movie, Patriot's Day. In this weeks Cowboy-Up Podcast Dr, Hamilton explains how the practice of neurosurgery, patients with terminal diseases, Artificial Intelligence and horses align.

Your Brain On
Your Brain On... Brain-Computer Interfaces

Your Brain On

Play Episode Listen Later May 7, 2025 51:37


Restoring a person's ability to speak, enabling individuals with paralysis to regain movement, and detecting neurodegenerative diseases earlier than ever — these are just some of the breakthroughs brain-computer interfaces are making possible. In this episode, we explore the astonishing world of BCIs: technologies that are giving autonomy and independence back to people with diseases like ALS. We discuss: • How BCIs are helping people with neurodegenerative diseases and spinal cord injuries communicate using decoded brain signals • How brain-computer interfaces actually work (and why they're NOT just reading your mind) • Why motor cortex implants may help decode speech, even when inserted in unexpected regions • The ethical challenges of privacy, data ownership, and access in the era of brain-connected devices • The future of the field, from restoring language after stroke to enabling communication in children with cerebral palsy We speak with three world-leading researchers and clinicians who are helping shape this rapidly-advancing area of neuroscience: • Dr. Leigh Hochberg, director of the Center for Neurotechnology and Neurorecovery at Massachusetts General Hospital, and principal clinical investigator of the pilot clinical trials of the BrainGate Neural Interface System. • Dr. David Brandman, neurosurgeon and co-director of the UC Davis Neuroprosthetics Lab. • Dr. Sergey Stavisky, neural engineer and co-director of the UC Davis Neuroprosthetics Lab. For more information about the Braingate project, and to volunteer as a participant, visit: https://braingate.org/ This is... Your Brain On Brain-Computer Interfaces. ‘Your Brain On' is hosted by neurologists, scientists and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Brain-Computer Interfaces' • SEASON 5 • EPISODE 3 ——— FOLLOW US Instagram: https://www.instagram.com/thebraindocs YouTube: https://www.youtube.com/thebraindocs Website: https://thebraindocs.com/

Health Is the Key
The Highs and Lows of Blood Pressure, with Dr. Robert Ostfeld

Health Is the Key

Play Episode Listen Later May 7, 2025 24:55


For Hypertension Awareness Month, we are fortunate to have Dr. Robert Ostfeld, a cardiologist at Montefiore Medical Center, join us to talk about lifestyle approaches for treating – and preventing – high blood pressure. In this episode, Dr. Ostfeld explains the numbers, the symptoms – or lack of symptoms – and the associated risks. A self-confessed “reformed cardiologist,” he talks about how he saw his patients who adopted a plant-based diet significantly lower their blood pressure. Not ready to go totally plant-based? Dr. Ostfeld says simply adding more fruits, vegetables and whole grains to your diet can help lower not only your blood pressure but also your risk for heart disease, stroke and dozens of other conditions.   The Takeaway We want to hear from you! Please complete our survey: org/member-feedback. Drop us a line at our social media channels: Facebook// Instagram // YouTube. Get started on your health journey by making an appointment with your primary care physician to know your numbers. Get to know your numbers at 1199SEIUBenefits.org/healthyhearts. Find healthy recipes and meal-prep tips at 1199SEIUBenefits.org/food-as-medicine. Visit the Healthy Living Resource Center for wellness tips, information and resources; 1199SEIUBenefits.org/healthyliving. Get inspired by fellow members through our Members' Voices series: 1199SEIUBenefits.org/healthyliving/membervoices. Stop by our Benefits Channel to join webinars on building healthy meals, managing stress and more: 1199SEIUBenefits.org/videos. Visit our YouTube channel to view a wide collection of healthy living videos: youtube.com/@1199SEIUBenefitFunds/playlists. Sample our wellness classes to exercise body and mind: 1199SEIUBenefits.org/wellnessevents. Robert Ostfeld, MD, MSc, FACC, is the Director of Preventive Cardiology at Montefiore Health System and a Professor of Medicine at the Albert Einstein College of Medicine. Dr. Ostfeld treats patients with adult cardiovascular disease, including coronary artery disease, hypertension, hyperlipidemia and erectile dysfunction with a focus on prevention and treatment through lifestyle change. He works closely with his patients to help them adopt a plant-based diet. Dr. Ostfeld received his Bachelor of Arts in the Biologic Basis of Behavior from the University of Pennsylvania, graduating Summa Cum Laude and Phi Beta Kappa and his Doctor of Medicine from Yale University School of Medicine. He then did his medical internship and residency at the Massachusetts General Hospital and his Cardiology Fellowship and Research Fellowship in Preventive Medicine at Brigham and Women's Hospital, both teaching hospitals of Harvard Medical School. During his Cardiology Fellowship, he earned a Master's of Science in Epidemiology from the Harvard School of Public Health. Dr. Ostfeld's research focus is on cardiovascular disease prevention and reversal through lifestyle modification. Ongoing topics he investigates include the impact of plant-based nutrition on erectile function, coronary artery disease, angina and heart failure. His work has been published in peer-reviewed journals, books, articles, and clinical statements and has been presented nationally. Dr. Ostfeld is board certified in Cardiovascular Disease and Echocardiography, and he is a member of numerous professional societies, including the Physician's Committee for Responsible Medicine and the American College of Cardiology.

Home Base Nation
Home Base Retrospective: A short conversation with Home Base Director of Veteran Outreach Jessica Covitz and a revisit to the Bob and Lee Woodruff episode

Home Base Nation

Play Episode Listen Later May 6, 2025 60:29


We have published 120 episodes since 2019. For this new season, we thought we would look back on some of the highlights of our conversations and choose 20 episodes that resonated with veterans, service members, military families, and the civilians who support them.But first up, you'll hear from some of the folks at Home Base who wake up every day with the same mission in mind, no matter what they do at the Center of Excellence in the Navy Yard and beyond.Over the next twenty weeks, we will share these staff conversations I had with some of the hard-working professionals at Home Base who help treat the invisible wounds of veterans and military families.For this first episode, you will hear a brief conversation with Home Base Navy Veteran Jessica Covitz, Director of Veteran Outreach. This will be followed by one of the earlier episodes, in which Ron sat with the incomparable Bob and Lee Woodruff of the Bob Woodruff Foundation. Many thanks to Jessica Covitz for all her work at Home Base in support of this mission to stomp stigma and treat the invisible wounds of veterans and military families.Run To Home Base: Join Ron and his team and sign up individually or on another team at the 16th annual Run To Home Base on July 26th, 2025, at Fenway Park! Go to runtohomebase.orgPlease go to homebase.org for updates, programming, and resources if you or anyone you know is struggling. Home Base Nation is the official podcast for the Home Base Program for Veterans and Military Families. Our team sees veterans, servicemembers, and their families addressing the invisible wounds of war at no cost. This is all made possible thanks to a grateful nation. If you want to learn more about how you can help, visit us at www.homebase.org. If you or anyone you know would like to connect to care, you can also reach us at 617-724-5202.Follow Home Base on Twitter, Facebook, Instagram, LinkedInThe Home Base Nation Team is Steve Monaco, Army Veteran Kelly Field, Justin Scheinert, Chuck Clough, with COO Michael Allard, Brigadier General Jack Hammond, and Peter Smyth.Producer and Host: Dr. Ron HirschbergAssistant Producer, Editor: Chuck CloughChairman, Home Base Media Lab: Peter SmythThe views expressed by guests on the Home Base Nation podcast are their own, and their appearance on the program does not imply an endorsement of them or any entity they represent. Views and opinions expressed by guests are those of the guests and do not necessarily reflect the views of the Massachusetts General Hospital, Home Base, the Red Sox Foundation, or any of its officials.

Research Renaissance: Exploring the Future of Brain Science
Exploring the Role of Astrocytes and APOE in Alzheimer's Disease with Dr. Alberto Serrano-Pozo

Research Renaissance: Exploring the Future of Brain Science

Play Episode Listen Later May 6, 2025 42:41 Transcription Available


In this episode of Research Renaissance, host Deborah Westphal sits down with Dr. Alberto Serrano-Pozo, Assistant Professor of Neurology at Harvard Medical School, staff neurologist at Massachusetts General Hospital, and a 2022 Toffler Scholar. Together, they explore Dr. Serrano-Pozo's pioneering research into the role of glial cells—specifically astrocytes—and the APOE gene in the development and progression of Alzheimer's disease.Dr. Serrano-Pozo discusses how astrocytes, long overlooked in favor of neurons, are now recognized as key players in maintaining brain health—and how their dysfunction may contribute to Alzheimer's pathology. The conversation also covers the complexities of the APOE gene variants, how recent discoveries are reshaping our understanding of Alzheimer's across different populations, and promising advances in gene-editing research.Dr. Serrano-Pozo also reflects on the dual role he plays as both a researcher and a clinician, how patient interactions inspire his lab work, and why cautious optimism is warranted as new therapies and technologies emerge.What You'll Learn:Why astrocytes are crucial to brain function—and how they change in Alzheimer'sThe evolving understanding of the APOE gene's role in Alzheimer's riskHow glial cells interact with amyloid plaques and tau tanglesWhy certain APOE variants affect populations differentlyAdvances in gene-editing that may offer future protection against Alzheimer'sThe real-world challenges and rewards of balancing clinical practice with researchA hopeful look at the accelerating pace of Alzheimer's research and innovationKey Quotes: 

Your Healthiest Healthy with Samantha Harris
Feed Your Brain, Fuel Your Mood with guest expert Dr. Uma Naidoo

Your Healthiest Healthy with Samantha Harris

Play Episode Listen Later Apr 30, 2025 31:58


Feed Your Brain, Fuel Your Mood!with guest expert Dr. Uma NaidooLife gets busy, and grabbing something quick feels like a win. But what if those convenient bites are actually messing with more than just your waistline?They're messing with your mind, too.When we think about it, any shift away from the standard American diet (you know, the one packed with fast food, processed snacks, and sugar bombs) is a move in the right direction. Most people talk about these foods being bad for your body, but what about your brain?Turns out, the way you eat could be one of the most powerful ways to take care of your mental health — starting today.In this episode, you will learn:How Food Affects Mental Health (Not Just Physical Health!) Why Whole Foods Are Better Than Processed Ones Eating the Rainbow: How Colorful Fruits and Veggies Boost Health The Gut-Mood Connection: A Happy Gut Equals a Happier Mind Are You Eating Enough to Fuel Your Brain? Where to Find Fiber in Your Diet Who Should Be Careful with Fiber for Gut Health America's Fiber Deficiency: What You Should Know How Antioxidants Fight Stress in Your Cells Boosting Mental Health with Spices Essential Foods for a Healthy Mind and Body How Food Can Help Prevent Inflammation What Your Gut Needs for a Happier Brain How Antioxidants Protect Your Brain The Dangers of Processed Foods on Mental Health How Gut Health Affects Emotional Regulation and Stress The Power of Phytonutrients: How Colorful Foods Support a Healthier Mind… And much more.About our guest expert:Dr. Uma Naidoo is a nutritional psychiatrist and serves as the director of nutritional & lifestyle psychiatry at Massachusetts General Hospital. She is on the faculty at Harvard Medical School. Dr. Naidoo trained at the Harvard Longwood Psychiatry Residency Training Program, and completed a consultation liaison fellowship at Brigham & Women's Hospital and Dana-Farber Cancer Institute.Dr. Naidoo studied nutrition, and she also graduated from the Cambridge School of Culinary Arts as a professional chef. She was awarded her culinary school's most coveted award, the MFK Fisher Award for Innovation. Dr. Naidoo is regarded nationally and internationally as a pioneer in the field of nutritional psychiatry, having founded the first US hospital-based clinical service in this area.She is the author of This is Your Brain on Food: An Indispensable Guide to the Surprising Foods that Fight Depression, Anxiety, PTSD, OCD, ADHD, and More. With her passion for food and nutritional psychiatry, she will share her expertise on the integration of food, mental health, and medicine.Instagram: https://www.instagram.com/drumanaidoo/Website: https://www.dailydoselife.com/meal-plans****************************************Get Jumping!! Rebounder Workouts = Cardio without ImpactI loooove my rebounder mini-trampoline workouts. Why? Efficient cardio without high-impact hurting my joints + the bonus of improving lymphatic flow.It's a great 1-2 punch to get a high energy, low-impact sweat on with the added benefit of using the trampoline as a step, bench and other uses to allow for building muscle (especially when you add-on...

Patient from Hell
The Microbiome's Impact on Colorectal Cancer Development + Survivorship Cancer Survivorship

Patient from Hell

Play Episode Listen Later Apr 30, 2025 50:10


In this episode of The Patient From Hell, host Samira Daswani speaks with Dr. Sara Char about her journey into oncology, the evolution of cancer biology, and the significant role of the microbiome in colon cancer. They discuss the complexities of cancer survivorship, the effectiveness of different methods of delivering survivorship care plans, and the importance of colonoscopy in monitoring colorectal cancer. The conversation also delves into the impact of diet on cancer risk, emphasizing the need for a comprehensive understanding of dietary patterns rather than focusing solely on individual foods. In this conversation, Dr. Sara Char discusses various aspects of survivorship care for colorectal cancer patients, focusing on dietary recommendations, exercise, and the emotional challenges faced during the transition from active treatment to survivorship. The dialogue emphasizes the importance of balancing nutrition, understanding the role of GLP-1 agonists, and the need for a supportive care team. Additionally, the conversation highlights the unique mental health needs of survivors and the significance of providing patients with a roadmap for their cancer journey.About Our Guest:Dr. Sara Char is a hematology and oncology fellow at Dana-Farber Cancer Institute. She specializes in the care of patients with gastrointestinal cancers with a specific interest in young-onset colorectal cancer. Her research explores the molecular underpinnings of diet and lifestyle factors implicated in colorectal cancer development and progression. Dr. Char received her M.D. from Tufts University School of Medicine and completed her residency training in internal medicine at Massachusetts General Hospital, where she also served as chief resident. Outside of work, she is a self-identified foodie and devoted dog-mom. Resources & Links:This episode was supported by the Patient Centered Outcomes Research Institute (PCORI) and features the PCORI research study here: https://pubmed.ncbi.nlm.nih.gov/34302474/ - ‘Simplifying Survivorship Care Planning: A Randomized Controlled Trial Comparing 3 Care Plan Delivery Approaches'Chapter Codes00:00 Exploring the Microbiome and Colon Cancer05:59 The Transition to Survivorship Care11:57 Understanding Adherence in Survivorship Plans17:49 The Role of Colonoscopy in Survivorship24:06 Dietary Patterns and Cancer Risk25:04 Inflammatory Diet and Health Outcomes28:11 Dietary Recommendations for Cancer Survivors30:34 Exercise and Body Composition in Cancer Care31:59 Managing GI Issues with GLP-1 Agonists34:43 Navigating Multidisciplinary Care35:50 The Transition from Active Treatment to Survivorship38:08 Mental Health Challenges Post-Treatment41:41 The Need for Psycho-Oncology Support46:47 The Importance of Patient Education and ResourcesConnect with Us:Enjoyed this episode? Make sure to subscribe, rate, and review! Follow us on Instagram, Facebook, or Linkedin @mantacares and visit our website at mantacares.com for more episodes and updates.Disclaimer:All content and information provided in connection with Manta Cares is solely intended for informational and educational purposes only. This content and information is not intended to be a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.This episode was supported by an award from the Patient-Centered Outcomes Research Institute.

SoundPractice
Surgical Competence and the Aging Surgeon Program with Dr. Mark Katlic

SoundPractice

Play Episode Listen Later Apr 30, 2025 27:34


Episode Summary: In this episode of SoundPractice, host Mike Sacopulos sits down with Mark Katlic, MD, the chair emeritus of surgery for LifeBridge Health System in Baltimore, Maryland. Katlic opens up about his illustrious career, the creation of the Aging Surgeon Program, and the essential topic of maintaining surgical competence as surgeons age. The Aging Surgeon Program: The program addresses the critical issue of age-related competency in the surgical field. It offers a comprehensive and unbiased evaluation that assesses the physical and cognitive functions of surgeons over the age of 70. Aimed to ensure the ongoing safety and proficiency of aging surgeons, it identifies treatable or reversible conditions that, if addressed, could enhance their functional capacity. By fostering a culture of self-regulation within multidisciplinary surgical teams, the program helps maintain public trust in the healthcare system. Key Points: - The necessity of avoiding a mandatory retirement age, as individual capabilities can vary widely. - The role of strict confidentiality protocols in identifying and addressing issues that might affect a surgeon's performance. - Potential solutions that modify work conditions, allowing experienced surgeons to continue contributing without compromising safety or forcing retirement. About Mark Katlic, MD: Katlic pursued education at Washington and Jefferson College, Johns Hopkins School of Medicine, and Massachusetts General Hospital. His extensive career spans private practice, general and thoracic surgery, and academic positions at Geisinger Health System and LifeBridge Health System. Tune in to this insightful episode to learn how the Aging Surgeon Program is making a difference in the surgical community. Learn more about the American Association for Physician Leadership.

Let's talk e-cigarettes
Let's talk e-cigarettes, April 2025

Let's talk e-cigarettes

Play Episode Listen Later Apr 30, 2025 20:31


Jamie Hartmann-Boyce and Nicola Lindson explore new e-cigarette research and speak with Eden Evins from Massachusetts General Hospital and Harvard Medical School, about her randomized clinical trial on varenicline for youth vaping cessation. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Eden Evins from Massachusetts General Hospital and Harvard Medical School, Boston. In the April podcast Eden Evins discusses the findings of their new randomised clinical trial to evaluate the efficacy of varenicline for nicotine vaping cessation in 261 treatment seeking youth (16-24 years) who do not smoke tobacco regularly. This study has just been published in JAMA, April 2025 (DOI:10.1001/jama.2025.3810 NCT05367492). Professor Evins describes her interest in the high use of vapes among young people and the speed at which this increase to a different flavoured form of nicotine has occurred. Professor Evins and her team thought that varenicline, a pill based drug that is used for quitting smoking, could work for vaping cessation. She talks about the huge demand to take part in the study and how the team had to pause recruitment to keep up. She describes how young people were indignant, they had not expected to become addicted. Professor Evins says that when young people found they couldn't sit through a study session without needing to vape they were surprised and felt taken advantage of by marketers and these flavored products that they had thought were for fun. Their study funded by the National Institutes of Health in the US shows that the continuous abstinence rates in the last month of treatment (51% vs 14%) and at 6-month follow-up (28% vs 7%) are higher in the varenicline group than in the placebo group. This was a 12-week trial with 6 month follow up. Treatment-emergent adverse events did not differ significantly between groups. In summary varenicline, when added to brief cessation counselling, is well tolerated and promotes nicotine vaping cessation compared with placebo in youth with addiction to vaped nicotine. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st April 2025 found 1 new ongoing study (NCT06789692) and 5 linked papers. Our search for our interventions for quitting vaping review up to 1st April 2025 found 3 new ongoing studies (NCT06862050; TCTR20250203006; NCT06885606), For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

10% Happier with Dan Harris
Never Worry Alone | Dr. Robert Waldinger

10% Happier with Dan Harris

Play Episode Listen Later Apr 28, 2025 63:11


Dr. Robert Waldinger talks about his new book The Good Life: Lessons From the World's Longest Scientific Study of Happiness, which explores lessons from the longest scientific study of happiness. Dr. Robert Waldinger is a professor of psychiatry at Harvard Medical School, the director of the Harvard Study of Adult Development at Massachusetts General Hospital, and co-founder of the Lifespan Research Foundation. He is also a Zen master and teaches meditation in New England and around the world. His TED Talk is one of the most viewed of all time, with over 43 million views. He's the co-author, along with Dr. Marc Schulz, of The Good Life.   In this episode we talk about:  What the Harvard Study of Adult Development is and how it got started How much of our happiness is really under our control Why you can't you be happy all the time The concept of “social fitness”  Why you should “never worry alone”  How having best friends at work can make you more productive And why, in his words, it's never too late to be happy   Join Dan's online community here Follow Dan on social: Instagram, TikTok Subscribe to our YouTube Channel  

Parallax by Ankur Kalra
Ep 133: South Asian Heart Health: Unveiling Risk Patterns and Prevention Strategies

Parallax by Ankur Kalra

Play Episode Listen Later Apr 28, 2025 55:07


In this compelling episode of Parallax, Dr Ankur Kalra explores South Asian cardiovascular health with preventive cardiology experts, Dr Jaideep Patel from Johns Hopkins, and Dr Romit Bhattacharya from Massachusetts General Hospital. The conversation begins with both specialists sharing personal motivations behind their focus on South Asian heart health, from family losses to scientific curiosity about potential genetic and metabolic distinctions. They examine whether South Asians truly face different cardiovascular risks - discussing observations of earlier disease onset, unique lipid patterns, and metabolic dysfunction at lower BMIs - while emphasizing that fundamental prevention strategies remain effective across populations. The episode culminates with powerful closing insights on prevention as an investment—how small, consistent lifestyle modifications can prevent cardiovascular disease onset even in those with genetic predispositions, ultimately enabling fuller, more functional lives in later years. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCARDIO

Hematologic Oncology Update
Immune Thrombocytopenia — A Roundtable Discussion on Current and Future Management Strategies

Hematologic Oncology Update

Play Episode Listen Later Apr 28, 2025 116:57


Dr Hanny Al-Samkari from Massachusetts General Hospital in Boston, Dr James B Bussel from Weill Cornell School of Medicine in New York, New York, and Prof Nichola Cooper from Hammersmith Hospital Campus in London, United Kingdom, share expert perspectives on the diagnosis of and optimal management strategies for immune thrombocytopenia. CME information and select publications here.

Surgical Hot Topics
#9, S1 Rethinking Lung Cancer Screening Eligibility

Surgical Hot Topics

Play Episode Listen Later Apr 28, 2025 35:05


In this episode of Thinking Thoracic, hear from Alexandra Potter, researcher, and Dr. Chi-Fu Jeffrey Yang, both from Massachusetts General Hospital, about a new study that reveals current lung cancer screening guidelines miss nearly half of patients who develop the disease. Alternative approaches could greatly expand access—especially for women, minorities, and former smokers. 

The Weekend University
Dr Lisa Feldman Barrett - How the Brain Creates Emotions

The Weekend University

Play Episode Listen Later Apr 24, 2025 56:30


Dr Lisa Feldman Barrett, who is in the top one percent of most cited scientists in the world for her revolutionary research in psychology and neuroscience. She is a Distinguished Professor of Psychology at Northeastern University, and also holds appointments at Harvard Medical School and Massachusetts General Hospital, where she is Chief Science Officer for the Center for Law, Brain & Behavior. In addition to the books Seven and a Half Lessons About the Brain and How Emotions are Made, Dr. Barrett has published over 260 peer-reviewed, scientific papers appearing in Science, Nature Neuroscience, and other top journals in psychology and cognitive neuroscience, as well as six academic volumes. She has also given a popular TED talk with over 6.5 million views. From this conversation, you'll learn: — Dr Barrett's groundbreaking theory of emotions and its implications for mental health and wellbeing — How emotional "granularity" can enhance your quality of life — Why everything we see is a "concept" and why this matters — Dr Barrett's thoughts on free will and personal responsibility. And more. You can learn more about Dr Barrett's work by going to: www.lisafeldmanbarrett.com --- Dr. Lisa Feldman Barrett is a psychologist, neuroscientist, professor, bestselling author, and one of the most cited scientists in the world. She received a National Institutes of Health Director's Pioneer Award for her revolutionary research on emotion in the brain. These highly competitive, multimillion dollar awards are given to scientists of exceptional creativity who are expected to transform biomedical and behavioral research. She also received a Guggenheim Fellowship in 2019, the APS Mentor Award for Lifetime Achievement in 2018, and the APA Distinguished Scientific Contribution Award in Psychology in 2021. Among her many accomplishments, Dr. Barrett has testified before Congress, presented her research to the FBI, consulted to the National Cancer Institute, appeared on Through The Wormhole with Morgan Freeman and The Today Show with Maria Shriver, and been a featured guest on public television and podcast and radio programs worldwide. She is also an elected fellow of the American Academy of Arts & Sciences and the Royal Society of Canada. --- Interview Links: — Seven and a Half Lessons About the Brain - Lisa Feldman Barrett: https://amzn.to/3CWM1VQ — How Emotions are Made - Lisa Feldman Barrett: https://amzn.to/3Rx1BeT — Dr Barrett's website: www.lisafeldmanbarrett.com — Matter and Consciousness - Dr Iain McGilchrist: https://bit.ly/3RGSQz0 3 Books Dr Porges Recommends Every Therapist Should Read: — Between us by Batja Mesquita - https://amzn.to/3FdYkxT — The End of Trauma by George Bonanno - https://amzn.to/3AW1fbL — How Emotions are Made by Lisa Feldman Barrett - https://amzn.to/3GVdxFl

Science and Spirituality with Deepak Chopra
Future-Proof Your Heart: Cutting-Edge Cardiac Health With Dr. Malissa Wood of Lee Health

Science and Spirituality with Deepak Chopra

Play Episode Listen Later Apr 24, 2025 41:57


In this episode of the Fully Alive podcast, host Zach Gurick sits down with the incredible Dr. Malissa Wood—Vice President and Chief Physician at the Lee Health Heart Institute, former Director of Cardiology at Massachusetts General Hospital, and a professor at Harvard Medical School. They dive deep into cardiac health—exploring cutting-edge tests, prevention strategies, and the empowering truth that 80% of heart disease can be prevented through simple lifestyle changes. From working with Olympians to leading groundbreaking research in women's heart health, Dr. Wood shares practical tips on how to take control of your heart health—no matter your age or medical history. Ready to future-proof your heart? Let's jump in! ---The information presented in Fully Alive is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before making changes to your health regimen. Guests' opinions are their own and do not necessarily reflect those of the podcast host, production team, or sponsors.

The Root of All Success with The Real Jason Duncan
287: The Hidden Costs of Burnout—and How to Break Free ft. Camilla Moore

The Root of All Success with The Real Jason Duncan

Play Episode Listen Later Apr 22, 2025 35:51


Think working 24/7 is the only path to success? Think again. In this episode of The Root of All Success, Jason Duncan sits down with Dr. Camilla Moore, a stress and burnout expert, entrepreneur, and certified instructor at Harvard's Benson Henry Institute. With a powerful blend of science, personal experience, and practical wisdom, Camilla shares what most entrepreneurs get wrong about stress—and how it could be silently sabotaging your business, health, and happiness. After building and selling a multi-six-figure practice, surviving COVID as a new mom in healthcare, and facing her own breaking point, Camilla now helps leaders and high-achievers reclaim their energy and rewire their approach to success—without burning out in the process.

Stimulating Brains
#70: Rees Cosgrove – When Neurosurgery Chooses You: Rediscovering the Lost Art of Lesions and the Future of Brain Stimulation

Stimulating Brains

Play Episode Listen Later Apr 22, 2025 110:08


In this episode, we journey through the remarkable career of Dr. Rees Cosgrove—a trailblazer in functional neurosurgery, Director of Epilepsy and Functional Neurosurgery at Brigham and Women's Hospital, and Professor of Neurosurgery at Harvard Medical School.Dr. Cosgrove reflects on his formative years training in the very halls that were roamed by legends such as Wilder Penfield at the Montreal Neurological Institute, and takes us through pivotal chapters of his career leading programs at Massachusetts General Hospital, Brown University, and now the Brigham. With a repertoire that spans from the golden era of ablative neurosurgery to modern deep brain stimulation and MR-guided focused ultrasound—where he has performed over 600 sonications—Dr. Cosgrove provides a unique perspective on how the field has transformed over the past several decades.Throughout the conversation, we delve into the history and resurgence of surgical lesions for psychiatric and neurological conditions, the nuances of neuromodulation technologies, and the evolution of imaging that now defines precision in brain surgery. Dr. Cosgrove also shares his views on mentorship, the transmission of surgical wisdom, and how we can preserve the disappearing art of lesioning in an age increasingly dominated by stimulation.Whether you're a neurosurgeon, neuroscientist, or simply curious about how we interface with the brain to treat disease, this episode is a rare and insightful look into the mind of one of the field's most experienced and thoughtful pioneers.

Historians At The Movies
Reckoning: The Search for Extraterrestrial Life with Dr. Mario Livio and Dr. Jack Szostak

Historians At The Movies

Play Episode Listen Later Apr 21, 2025 60:26


Today astrophysicist Dr. Mario Livio and Nobel-winning chemist Dr. Jack Szostak drop in to talk about the search for extraterrestrial life.About our guests:Dr. Mario Livio is an internationally known astrophysicist, best-selling author, and popular speaker. He is a Fellow of the American Association for the Advancement of Science. ​Dr. Livio has published more than 500 scientific articles. He has made significant theoretical contributions to topics ranging from cosmology, supernova explosions, and black holes to extrasolar planets and the emergence of life in the universe. He has received numerous awards and recognitions for his research, including having been selected as the “Carnegie Centenary Professor” by the universities of Scotland in 2003, and as the “Danz Distinguished Lecturer” by the University of Washington in 2006. Dr. Livio is also the author of eight popular science books, the most recent in collaboration with Nobel laureate Jack Szostak. His bestselling book The Golden Ratio won him the Peano Prize in 2003 and the International Pythagoras Prize in 2004, as the best popular book on mathematics. His book Is God A Mathematician? inspired the NOVA program “The Great Math Mystery,” which was nominated for an EMMY in 2016. His book Brilliant Blunders was selected by The Washington Post as one of the Notable Books of 2013. His book Galileo and the Science Deniers appeared in May 2020, and was one of the finalists for the Phi Beta Kappa Award in Science. Dr. Jack Szostak is a  biologist, Nobel Prize laureate, university professor at the University of Chicago, former professor of genetics at Harvard Medical School, and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, Boston. Szostak has made significant contributions to the field of genetics. His achievement helped scientists to map the location of genes in mammals and to develop techniques for manipulating genes. His research findings in this area are also instrumental to the Human Genome Project. He was awarded the 2009 Nobel Prize for Physiology or Medicine, along with Elizabeth Blackburn and Carol W. Greider, for the discovery of how chromosomes are protected by telomeres.

Choses à Savoir SANTE
BONUS - Que se passe-t-il dans le cerveau pendant une anesthésie ?

Choses à Savoir SANTE

Play Episode Listen Later Apr 18, 2025 3:53


Aujourd'hui, je vous emmène dans un voyage fascinant à l'intérieur du cerveau...Un moment mystérieux que beaucoup ont vécu, mais que peu comprennent vraiment : l'anesthésie générale.Remontons un instant dans le passé.Le 16 octobre 1846, à Boston, au Massachusetts General Hospital, un dentiste du nom de William Morton réalise la première démonstration publique réussie d'une anesthésie générale à l'éther.Ce jour-là, un patient subit l'ablation d'une tumeur au cou... sans douleur, ni cri.Une révolution est née.Avant cela, la chirurgie relevait de l'épreuve de force : on opérait à vif, rapidement, et dans la souffrance.Depuis cette date, l'anesthésie générale a sauvé des millions de vies en rendant possibles des interventions longues, complexes… et indolores.Lorsque vous êtes allongé sur la table, une équipe vous entoure. Une seringue est connectée à votre bras, une substance s'écoule. Et, très vite... plus rien.Pas de rêve, pas de sensation, pas de douleur. Comme si l'on avait appuyé sur un bouton "off".Mais ce n'est pas un simple sommeil.Des études en imagerie cérébrale montrent que l'anesthésie ne mime pas le sommeil, mais provoque une déconnexion brutale entre les différentes zones du cerveau, notamment entre le thalamus – une sorte de centre de tri sensoriel – et le cortex, responsable de la conscience.Les signaux sensoriels n'arrivent plus à destination. Résultat : le cerveau ne perçoit plus le monde extérieur.Ce phénomène est orchestré par des molécules puissantes : propofol, kétamine, halogénés comme le sévoflurane… Ces agents anesthésiques modifient en profondeur la chimie cérébrale.Leur cible principale ? Les neurotransmetteurs, ces messagers chimiques entre les neurones.Parmi eux, le plus important ici s'appelle GABA, le grand régulateur de l'activité neuronale.Les molécules anesthésiques agissent comme des "amplificateurs" de ce neurotransmetteur.En se liant à ses récepteurs, elles renforcent son effet inhibiteur, ralentissant ou stoppant carrément la transmission des signaux nerveux.Résultat ?Le cerveau devient moins excitable, les réseaux de neurones cessent de communiquer efficacement entre eux, et l'activité cérébrale s'effondre progressivement, un peu comme si on plongeait un ordinateur en mode veille.Mais ce n'est pas tout.D'autres molécules anesthésiques comme la kétamine bloquent un autre récepteur fondamental : le NMDA, impliqué dans la transmission de la douleur et de la conscience.D'autres encore agissent sur des canaux ioniques, modifiant la façon dont les neurones échangent les signaux électriques.En clair : c'est tout un orchestre neurochimique qui est désorganisé volontairement, pour plonger le cerveau dans un état de silence contrôlé.Et pourtant, le cerveau n'est pas mort. Il continue de réguler la respiration, le rythme cardiaque, la température... comme s'il restait en mode automatique.Puis vient le réveil. Là encore, c'est mystérieux : certains patients mettent quelques secondes, d'autres plusieurs minutes.Le cerveau se reconnecte progressivement. Il n'est pas rare de se sentir confus, désorienté, voire agité dans les premières minutes.Et dans de très rares cas – un pour 15 000 environ – une conscience résiduelle peut persister pendant l'opération : on parle alors de conscience peropératoire.Le patient est paralysé, incapable de parler, mais entend ou ressent partiellement. Cela reste rare, mais suffisamment sérieux pour que les anesthésistes utilisent aujourd'hui des moniteurs de profondeur d'anesthésie. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

From The Green Notebook
Mastering Your Emotions with Dr. Lisa Feldman Barrett

From The Green Notebook

Play Episode Listen Later Apr 17, 2025 72:43


Send us a textIn this episode, Joe sits down with Dr. Lisa Feldman Barrett, a leading neuroscientist and author of How Emotions Are Made, to explore groundbreaking insights on how emotions are formed and how we can better understand and regulate them. Together, they dive deep into the science behind emotions, how the brain predicts our feelings, and how we can gain more emotional agency in our personal and professional lives. Joe and Dr. Barrett cover:The theory of constructed emotions and how emotions are predictions, not reactionsThe role of the brain in regulating the body and how it shapes emotional experiencesWhy uncertainty feels like anxiety—and how to reframe itHow emotional granularity can help us build better emotional vocabulary and controlPractical steps to improve emotional regulation and decision-makingThe impact of body budgeting on mood, stress, and overall healthWhether you're leading a team, navigating personal relationships, or simply trying to better understand your emotional life, this conversation will give you powerful tools to enhance your emotional intelligence and well-being.Lisa Feldman Barrett, PhD, is among the top 0.1% most cited scientists in the world for her revolutionary research in psychology and neuroscience. She is a University Distinguished Professor of Psychology at Northeastern University. She also holds appointments at Harvard Medical School and Massachusetts General Hospital, where she is Chief Science Officer for the Center for Law, Brain & Behavior.In addition to the books Seven and a Half Lessons About the Brain and How Emotions are Made, Dr. Barrett has published over 275 peer-reviewed, scientific papers appearing in Science, Nature Neuroscience, and other top journals in psychology and cognitive neuroscience, as well as six academic volumes published by Guilford Press. She writes regularly about science in the popular press, including The New York Times, The Guardian, Scientific American, BBC Science Focus, Popular Science, Nautilus, BigThink, Cosmopolitan,  Time magazine, MIT Technology Review, and more (see full list). Her popular TED talk has been viewed over 7 million times.A Special Thanks to Our Sponsors!Veteran-founded Adyton. Step into the next generation of equipment management with Log-E by Adyton. Whether you are doing monthly inventories or preparing for deployment, Log-E is your pocket property book, giving real-time visibility into equipment status and mission readiness. Learn more about how Log-E can revolutionize your property tracking process here!Meet ROGER Bank—a modern, digital bank built for military members, by military members. With early payday, no fees, high-yield accounts, and real support, it's banking that gets you. Funds are FDIC insured through Citizens Bank of Edmond, so you can bank with confidence and peace of mind. Visit

Right Up My Podcast
RUMP Rewind – Ep.43 - Meditation & The Brain: How meditation can reshape our brains | Sara Lazar

Right Up My Podcast

Play Episode Listen Later Apr 14, 2025 62:41


It's the RUMP Rewind! Where we delve into the back catalogue and whip out an old fave that we think needs a re-airing today. Kate's chosen to re-explore the vast benefits of meditation on our brain and lives.Sara Lazar joined us on Ep.43 to talk about what's actually happening in our brains when we meditate. We're all told it's good for us, but we want to find out why.Sara is an Assistant Professor in Psychology at Harvard Medical School and an Associate Researcher in Psychiatry at Massachusetts General Hospital. Her research focuses on the neuroscience underlying yoga and meditation. Her work has been covered by the likes of The New York Times and in TED talks, and you can find out more about her here:How Meditation Can Reshape Our Brains: Sara Lazar at TEDxCambridge The Neuroscience of Yoga and Meditation - Dr Sara Lazar, PhDSara sets us one our loveliest challenges so far: to meditate while sending love out to others. Gwen & Kate try it out and you can join in too. For all RUMP info in one place: visit our linkt.ree Get a shout-out:Want a mention on the next RUMPette? Tell us your feedback or what you do to make yourself feel good: rightupmypodcast@gmail.com Support RUMP: If you enjoy the podcast, please subscribe, share with your friends and leave a review. It takes less than 60 seconds and really makes a difference in helping people discover the podcast. Thank you! Join the RUMP Club! Support the team and access exclusive content from as little as £3 p/month at: Right Up My Podcast | Patreon Or, if you'd like to make a one-off donation, you can buy us a virtual coffee from Buy Me a Coffee! Be social with us:Instagram Facebook TikTok Thank you to our team:Music - Andrew GrimesArtwork - Erica Frances GeorgeSocial Media - Kate Balls

Lung Cancer Update
First-Line Therapy for Metastatic Non-Small Cell Lung Cancer and an ALK Rearrangement — An Interview with Dr Justin F Gainor

Lung Cancer Update

Play Episode Listen Later Apr 10, 2025 57:28


Dr Justin F Gainor from Massachusetts General Hospital in Boston reviews available clinical data on ALK inhibitors and first-line treatment strategies for ALK-positive metastatic non-small cell lung cancer. CME information and select publications here.

Health Matters
How Does Alcohol Impact the Gut Microbiome?

Health Matters

Play Episode Listen Later Apr 2, 2025 14:09


This week on Health Matters, Courtney Allison is joined by Dr. Stephanie Rutledge, transplant hepatologist with NewYork-Presbyterian and Weill Cornell Medicine.They dig into a fascinating connection between the health of the gut microbiome and the health of the liver, by exploring the impacts of drinking alcohol on both. Microbes in the gut are affected by what we eat and drink, and the consequences of drinking alcohol may be more serious than you expect. Dr. Rutledge describes how serious cases may even require a fecal transplant.But there are simple steps you can take to improve the health of your gut microbiome. Dr. Rutledge describes how quickly a dysfunctional microbiome can recover once someone stops drinking, and offers health tips that can improve anyone's liver health. Even just a month of better habits can have big results for the gut microbiome, the liver, and overall health.___Dr. Stephanie Rutledge is a gastroenterologist and transplant hepatologist with NewYork-Presbyterian Hospital/Weill Cornell Medical Center. She treats alcohol use disorder and alcohol-associated liver disease with Weill Cornell Medicine's Center for Alcohol and Liver Medicine (CALM). Dr. Rutledge received her MBBCh BAO from University College Dublin, completed residency at Massachusetts General Hospital, and completed her Gastroenterology and Transplant Hepatology Fellowship at Mount Sinai Hospital.___Health Matters is your weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine. To learn more visit: https://healthmatters.nyp.org

Late Night Health
Are Vaccines Good For Us?

Late Night Health

Play Episode Listen Later Mar 29, 2025 24:39


Are Vaccines Good For Us? Marschall S. Runge, M.D., Ph.D., was born in Austin, Texas, and graduated from Vanderbilt University with a BA in General Biology and a PhD in Molecular Biology. He received his medical degree from the Johns Hopkins School of Medicine and trained in internal medicine at Johns Hopkins Hospital. He was a cardiology fellow and junior faculty member at Massachusetts General Hospital. Dr. Runge's next position was at Emory University, where he directed the Cardiology Fellowship Training Program. He then moved to the University of Texas Medical Branch in Galveston, where he was Chief of Cardiology and Director of the Sealy Center for Molecular Cardiology. He joined the University of North Carolina (UNC) from 2000 – 2014, where he served as Charles Addison and Elizabeth Ann Sanders Distinguished Professor of Medicine, Chair of the Department of Medicine, President of UNC Physicians and Vice Dean for Clinical Affairs. Dr. Runge visits with Mark Alyn.Become a supporter of this podcast: https://www.spreaker.com/podcast/late-night-health-radio--2804369/support.

Late Night Health Radio
Are Vaccines Good For Us?

Late Night Health Radio

Play Episode Listen Later Mar 29, 2025 24:39


Are Vaccines Good For Us? Marschall S. Runge, M.D., Ph.D., was born in Austin, Texas, and graduated from Vanderbilt University with a BA in General Biology and a PhD in Molecular Biology. He received his medical degree from the Johns Hopkins School of Medicine and trained in internal medicine at Johns Hopkins Hospital. He was a cardiology fellow and junior faculty member at Massachusetts General Hospital. Dr. Runge's next position was at Emory University, where he directed the Cardiology Fellowship Training Program. He then moved to the University of Texas Medical Branch in Galveston, where he was Chief of Cardiology and Director of the Sealy Center for Molecular Cardiology. He joined the University of North Carolina (UNC) from 2000 – 2014, where he served as Charles Addison and Elizabeth Ann Sanders Distinguished Professor of Medicine, Chair of the Department of Medicine, President of UNC Physicians and Vice Dean for Clinical Affairs. Dr. Runge visits with Mark Alyn.Become a supporter of this podcast: https://www.spreaker.com/podcast/late-night-health-radio--2804369/support.

The House of Surgery
Fireside Chat with Dr. Keith Lillemoe

The House of Surgery

Play Episode Listen Later Mar 28, 2025 54:03


This episode features a fireside chat with Keith D. Lillemoe, MD, FACS, who is the surgeon in chief at Massachusetts General Hospital in Boston and the W. Gerald Austen Professor of Surgery at Harvard Medical School. Dr. Lillemoe talks about his surgical career, developing expertise in gallbladder and biliary tract disease, and lessons learned along the way. The program host is Dr. Mohsen Shabahang for the ACS Academy of Master Surgeon Educators.   Talk about the podcast on social media using the hashtag #HouseofSurgery.

The Operative Word from JACS
E32: Validation of Artificial Intelligence-Based POTTER Calculator in Emergency General Surgery Patients Undergoing Laparotomy: Prospective, Bi-Institutional Study

The Operative Word from JACS

Play Episode Listen Later Mar 20, 2025 25:43 Transcription Available


In this episode, Tom Varghese, MD, FACS, is joined by Haytham Kaafarani, MD, MPH, FACS, and Vahe Panossian, MD, from the Department of Surgery, Massachusetts General Hospital and Harvard Medical School. They discuss the recent article by Drs Kaafarani and Panossian, “Validation of Artificial Intelligence-Based POTTER Calculator in Emergency General Surgery Patients Undergoing Laparotomy: Prospective, Bi-Institutional Study.” This study found that POTTER accurately predicts mortality and postoperative complication, and the superior accuracy, user-friendliness, and interpretability of POTTER make it a useful bedside tool for preoperative counseling.    Disclosure Information: Drs Varghese and Panossian have nothing to disclose. Dr Kaafarani receives honoraria payments from UpToDate. The POTTER calculator is available online for free, and Dr Kaafarani has not been compensated for the development or ongoing use of the calculator.  To earn 0.25 AMA PRA Category 1 Credits™ for this episode of the JACS Operative Word Podcast, click here to register for the course and complete the evaluation. Listeners can earn CME credit for this podcast for up to 2 years after the original air date. Learn more about the Journal of the American College of Surgeons, a monthly peer-reviewed journal publishing original contributions on all aspects of surgery, including scientific articles, collective reviews, experimental investigations, and more. #JACSOperativeWord

The Health Disparities Podcast
Weight bias is pervasive – what can be done about it? A conversation with obesity medicine specialist Dr. Fatima Cody Stanford

The Health Disparities Podcast

Play Episode Listen Later Mar 19, 2025 32:36 Transcription Available


Weight bias is pervasive and is one of the most common forms of bias in the U.S.  When it comes to obesity medicine, patients can be their worst critics, says Dr. Fatima Cody Stanford, an obesity medicine physician scientist, educator, and policy maker at Massachusetts General Hospital and Harvard Medical School. “They're their worst critics because what they've heard from their doctors, their family members, their peers is that they have failed,” Dr. Stanford says. “My goal is to help them realize that they're not, indeed, a failure. There are options. We can treat  this disease. We do have treatments available.” Dr. Stanford is a national and international sought-after expert in obesity medicine who bridges the intersection of medicine, public health, policy, and disparities. She joins the Health Disparities podcast to discuss weight bias, how that bias causes stress, and the role of stress in obesity. This episode was originally published in 2019 with host Dr. Bonnie Mason Simpson. Never miss an episode – be sure to subscribe to The Health Disparities podcast from Movement Is Life on Apple Podcasts, YouTube, or wherever you get your podcasts.

New England Journal of Medicine Interviews
NEJM Interview: Alex Keuroghlian on responding to policy threats to protections for transgender and nonbinary people.

New England Journal of Medicine Interviews

Play Episode Listen Later Mar 12, 2025 9:58


Alex Keuroghlian is an associate professor of psychiatry at Harvard Medical School and the director of the Division of Public and Community Psychiatry at Massachusetts General Hospital. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.R.A. Coelho, A.L. Chen, and A.S. Keuroghlian. Advancing Transgender Health amid Rising Policy Threats. N Engl J Med 2025;392:1041-1044.

RealTalk MS
An ACTRIMS Forum Conversation with Dr. Nara Michaelson

RealTalk MS

Play Episode Listen Later Mar 10, 2025 7:16


Just a couple of weeks ago, 1,800 scientists, clinicians, postdoctoral fellows, and medical residents gathered in West Palm Beach, Florida, for the Americas Committee for Treatment and Research in Multiple Sclerosis annual meeting, better known as the ACTRIMS Forum. Dr. Nara Michaelson is a Multiple Sclerosis Fellow at Harvard's Massachusetts General Hospital. We first talked with Dr. Michaelson last summer when her article, The Unraveling, was published in the journal, Neurology.  At the ACTRIMS Forum, we talked with Dr. Michaelson about how she uses arts therapy with her patients, and how lessons learned studying piano when she was 8 years old continue to serve her today in her work as an MS specialist.  We have a lot to talk about! Are you ready for RealTalk MS??! SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/actrims02 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com RealTalk MS on YouTube https://www.youtube.com/@RealTalkMS Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Bonus Episode Guest: Dr. Darin Okuda Privacy Policy

The Crossway Podcast
Unicorns, Allegory, and Stories That Give Us Hope (Kathryn Butler)

The Crossway Podcast

Play Episode Listen Later Feb 17, 2025 33:16


In this episode, Kathryn Butler shares her experience writing The Dreamkeeper Saga and encourages Christians to steward their daydreams for the glory of God. Kathryn Butler trained in surgery and critical care at Massachusetts General Hospital and Harvard Medical School, where she then joined the faculty. She is also the author of the Dream Keeper Saga which just concluded with the fifth and final book 'The Last Keeper'. Read the full transcript of this episode. ❖ Listen to “Dragons, Absent Fathers, and Stories That Heal” with Kathryn Butler: Apple Podcasts | Spotify | YouTube If you enjoyed this episode be sure to leave us a review, which helps us spread the word about the show!

Make Me Smart
Trump’s purge of federal workers and its historical parallels

Make Me Smart

Play Episode Listen Later Feb 11, 2025 17:46


President Donald Trump’s recent steps to remove federal employees is drawing comparisons to government purges during the Red Scare of the 1950s. What's at stake when government workers are pushed out? We’ll break it down. Plus, we’ll explain why a ruling in one of the lawsuits over Trump’s funding freeze is a biggie. Finally, tell us something good that happened to you lately! Here's everything we talked about today: “Judge Rules That Trump Administration Defied Order to Unfreeze Billions in Federal Grants” from The New York Times “Trump Eases Enforcement of Law Banning Overseas Bribes” by Bloomberg “What Happened the Last Time a President Purged the Bureaucracy” from Politico “CBS News poll — Trump has positive approval amid ‘energetic’ opening weeks; seen as doing what he promised” by CBS News “Second pig kidney transplant successfully completed at Massachusetts General Hospital” from WCVB Channel 5 “Experimental transplants with organs from gene-edited pigs see major steps forward” from CNN “A campus sign said ‘Tell us something good.' Students delivered.” by The Washington Post Tell us something good that happened to you recently! Email us at makemesmart@marketplace.org or leave us a voicemail at 508-U-B-SMART.

Marketplace All-in-One
Trump’s purge of federal workers and its historical parallels

Marketplace All-in-One

Play Episode Listen Later Feb 11, 2025 17:46


President Donald Trump’s recent steps to remove federal employees is drawing comparisons to government purges during the Red Scare of the 1950s. What's at stake when government workers are pushed out? We’ll break it down. Plus, we’ll explain why a ruling in one of the lawsuits over Trump’s funding freeze is a biggie. Finally, tell us something good that happened to you lately! Here's everything we talked about today: “Judge Rules That Trump Administration Defied Order to Unfreeze Billions in Federal Grants” from The New York Times “Trump Eases Enforcement of Law Banning Overseas Bribes” by Bloomberg “What Happened the Last Time a President Purged the Bureaucracy” from Politico “CBS News poll — Trump has positive approval amid ‘energetic’ opening weeks; seen as doing what he promised” by CBS News “Second pig kidney transplant successfully completed at Massachusetts General Hospital” from WCVB Channel 5 “Experimental transplants with organs from gene-edited pigs see major steps forward” from CNN “A campus sign said ‘Tell us something good.' Students delivered.” by The Washington Post Tell us something good that happened to you recently! Email us at makemesmart@marketplace.org or leave us a voicemail at 508-U-B-SMART.

The Art of Charm
Negotiating Disagreement | Robert Bordone & Joel Salinas

The Art of Charm

Play Episode Listen Later Jan 6, 2025 64:30


In today's episode, we dive into the science of managing conflict and building resilience with Bob Bordone and Joel Salinas, two thought leaders in negotiation and emotional intelligence. Bob Bordone, a senior fellow and former professor at Harvard Law School, is the founder of the Harvard Negotiation and Mediation Clinical Program. Joel Salinas, a neurologist at Massachusetts General Hospital and an instructor at Harvard Medical School, brings a unique perspective from his research in brain science and social connection. Together, they coauthored Conflict Resilience: Negotiating Disagreement Without Giving Up or Giving In, a groundbreaking book that redefines how we approach conflict, not as something to fear but as a powerful opportunity for growth. Join us for an eye-opening conversation with negotiation expert Bob Bordone and neurologist Joel Salinas as they unravel the complex dynamics of conflict and emotional resilience. Why does conflict feel so uncomfortable, and how can we reframe it as an opportunity for growth? How do our brains influence our reactions in high-stakes disagreements, and what strategies can we use to navigate even the toughest conversations? Bob and Joel combine their expertise in negotiation, brain science, and emotional intelligence to offer actionable tools for managing tension, building conflict resilience, and fostering deeper connections in both personal and professional settings. Discover how mastering these skills can enhance your relationships, elevate your leadership, and transform the way you approach challenges. What to Listen For Introduction – 00:00:00 Why do they see conflict as an opportunity for growth rather than something to fear? The Science of Conflict and Emotional Triggers – 00:05:07 Why does conflict trigger the same brain mechanisms as physical pain? How can pausing and breathing help re-engage the rational parts of the brain during conflict? What are the first steps to managing emotional triggers in high-stakes disagreements? Naming the Core Issues Behind Conflict – 00:10:37 What does “naming” mean in the context of conflict resilience, and how does it transform conversations? Why is it important to identify and express the emotions underlying a disagreement? How can naming your feelings help de-escalate tension and get to the heart of the problem? The Power of Emotional Vocabulary – 00:16:53 Why do many people struggle to articulate their feelings, especially men? How does a richer emotional vocabulary lead to better conflict outcomes? What practical exercises can help you expand your emotional awareness? Balancing Self and Others in Conflict – 00:30:48 How can highly empathetic individuals set healthy boundaries without feeling guilty? What are the challenges of balancing your own needs with the needs of others? Why is it essential to prepare for how others might react when you assert your needs? Building Conflict Resilience – 00:33:29 What is conflict resilience, and how does it differ from conflict resolution? Why is resilience a prerequisite for effective negotiation and communication? How can you cultivate the mindset and skills to stay present and engaged during disagreements? Creating a Greenhouse for Conflict Resilience – 00:43:12 Why do hostile environments make it harder to engage constructively in conflict? What can leaders do to foster a culture that supports conflict resilience? How does the organization Seeds of Peace inspire young leaders to navigate conflict? Honing Curiosity and Avoiding Misjudgments – 00:47:00 How can curiosity help you uncover the true motivations behind someone's actions? Why do we often misinterpret others' identities and intentions in conflict? What techniques can help you think beyond your own perspective and stay curious longer? Learn more about your ad choices. Visit megaphone.fm/adchoices