Podcasts about yale

Note: This episode originally aired on March 4. Sam is currently on parental leave and will have new episodes out in early August.On this episode, Sam is joined by Craig Haley, the FCS Senior Editor for Stats Perform/The Analyst. The two discuss:-FCS championship future-Private equity in the playoffs-Penn hiring Rick Santos, and Yale hiring Kevin Cahill-Future realignment-Where has the FCS improved over Craig's time covering the subdivision, and where has it weakened?-Parity in the FCS-And moreThe podcast is presented by HERO Sports and BetMGM. Visit HERO Sports for FCS coverage and BetMGM for online betting odds.

It's Rory's move in day at Yale! Really spurs up those first-day-of-college emotions for us! Hosted on Acast. See acast.com/privacy for more information.

Estás escuchando #JUNTOSRadio: Cuidando a nuestras familias: prevención e información sobre el sarampión. ¿Qué es y cómo se contagia? ¿Cómo se puede tratar y de qué manera podemos prevenir la enfermedad? Mitos y realidades sobre el sarampión. El Dr. Fernando Merino, Profesor Asistente de Medicina en la División de Enfermedades Infecciosas del Departamento de Medicina del Sistema de Salud de la Universidad de Kansas nos responde estas y otras preguntas. Sobre nuestro invitado: El Dr. Merino obtuvo su título de Médico en la Universidad del País Vasco, en España. Tras graduarse de la Facultad de Medicina, cursó una Maestría en Medicina Tropical en la Universidad de Valencia, también en España. Su formación en Medicina Interna tuvo lugar en el Newton Wellesley Hospital de la Universidad de Tufts, en Massachusetts. Posteriormente, completó su formación de subespecialidad en Enfermedades Infecciosas en la Universidad de Yale, en New Haven, Connecticut. Antes de trasladarse a Kansas en 2007, ejerció su profesión en dos hospitales comunitarios en los estados de Texas y Nueva York. En ambos hospitales se desempeñó como Jefe de Enfermedades Infecciosas y Presidente de los comités de Control de Infecciones y de Optimización del Uso de Antibióticos. El Dr. Merino cuenta con una amplia experiencia clínica, tanto en el tratamiento de infecciones que requieren ingreso hospitalario como en el de aquellas enfermedades que pueden ser manejadas de forma ambulatoria. Sus principales áreas de interés son las infecciones del sistema nervioso central, la infección por VIH, las hepatitis virales, las infecciones en pacientes inmunocomprometidos, las infecciones osteoarticulares, las enfermedades causadas por *Streptococcus pneumoniae* y las enfermedades prevenibles mediante vacunación. Recursos informativos en español CDC información sobre vacunación https://www.cdc.gov/measles/es/vaccines/vacunacion-contra-el-sarampion.html OPS información/ recomendaciones https://es.aft.org/childrens-health/mental-health/eating-disorders Facebook: @juntosKS Instagram: juntos_ks YouTube: Juntos KS Página web: http://juntosks.org Suscríbete en cualquiera de nuestras plataformas de Podcast: Podbean, Spotify, Amazon Music y Apple Podcast - Juntos Radio Centro JUNTOS 4125 Rainbow Blvd. M.S. 1076, Kansas City, KS 66160 Este programa es únicamente con fines educativos. Para recibir un diagnóstico o tratamiento, consulte a su médico. La información proporcionada por el invitado es responsabilidad de este. No tenemos los derechos de autor de la música que aparece en este video. Todos los derechos de la música pertenecen a sus respectivos creadores.

Most people settle for being good, Lou Diamond Phillips shows how leaning into your true talent can turn you into unforgettable. From childhood plays in the Philippines to Hollywood stardom, he reveals the secret to giving yourself permission to dream big and embrace your unique path, even when the odds are stacked against you.In this episode, Lou shares the raw story behind his first play in sixth grade, how a military family shaped his resilience, and the moment his dad finally believed in his acting dream. Discover how a Texas theater scene launched his career before Hollywood called, and why choosing Dallas over Yale was the decision that changed everything for his path to fame.Maverick Podcast // Episode 175Lou Diamond Phillips:https://www.imdb.com/name/nm0001617Maverick Podcast:

Ep. 526 | Dyslexia & Elite Athletes: The Hidden Sports AdvantageSports Chasers Interview Sessions | June 8, 2026Muhammad Ali. Magic Johnson. Tim Tebow. Nolan Ryan. Elite. Decorated. Legendary. And all dyslexic. In this Sports Chasers Interview Session, host Kevin L. Warren sits down with Russell Van Brocklen — The Dyslexia Professor — for one of the most unexpected and powerful conversations in Sports Chasers history.Russell draws on Yale-based science from Dr. Sally Shaywitz's Overcoming Dyslexia to explain why dyslexic learners aren't broken — they're built differently. And in high-strategy positions like quarterback, that difference may be an outright competitive advantage.

A Portfolio Checklist Extra adásában hatodik alkalommal beszélgetünk az amerikai felsőoktatás elitjébe tartozó Borostyán Ligába, angolul Ivy League-be tartozó egyetemek magyar diákjaival. Hallgatóink a harvardos Kovács Ferenc Somát és a yale-es Szepesi Mórt már jól ismerhetik, a csapat azonban bővült: a mai műsorban csatlakozott hozzájuk a University of Pennsylvania egyetemről Madár Gergely is. Így most már négyen beszélgetünk többek között arról, hogy csapódott le az USA-ban a magyar választások eredménye, hogy látják Donald Trump elmúlt fél éves ténykedését az egyetemeken, mit gondolnak ők az amerikai tőkepiacon zajló folyamatokról, és hogy kik most az igazi sztárok az USA top egyetemistáinak körében. Főbb részek: Intro – (00:00) Bemutatkozik a University of Pennsylvania is – (01:25) Harvardi félév: sportsérülések és amerikai kezelésük – (07:00) A Yale Political Union magyar elnöke, és tevékenysége – (14:20) Az amerikai egyetemisták sztárjai: Hasan Piker és Curtis Sliwa – (17:50) Mit jelent Amerikában a szélsőbaloldaliság? – (22:47) Az USA-ban lőnek is – (27:10) Hogy néztek ki Amerikából a magyar választások? – (29:30) Sulyok Tamást a Yale-en húszan védték – (39:30) Orbán Viktor sorsa várhat Donald Trumpra? – (42:00) Donald Trump viselt dolgai: újabb impeachment közeleg? – (47:15) Scott Galloway magyar hasonlata a hormuzi helyzetre – (54:30) Az USA makroproblémái – (1:02:40) Iránnal szemben Trump nem tud TACO-zni – (1:07:15) Tőkepiaci dilemmák Amerikában – (1:10:00) AI-sztorik a felsőoktatásból – (1:15:00) Nyári és őszi tervek – (1:36:55) Miért nincs magyar unikornis? – (1:40:00) McKinsey gyakorlat az USA-ban – (1:43:00) A műsor edukációs és szórakoztató céllal készül, így az abban elhangzó beszélgetés semelyik eleme nem minősül befektetési tanácsadásnak. Amennyiben valódi, hivatalos befektetési tanácsot szeretne, akkor keresse az Invest szakmai partnerét, a Portfolio Investment Servicest. Ez a Portfolio Csoport privátbanki üzletága az Erste Befektetési Zrt. függő ügynökeként, és itt többek között olyan szakemberek segítik az ügyfelek befektetési döntéseit, mint Nagy Viktor és elemző kollégái.See omnystudio.com/listener for privacy information.

Matt Elkin is in his second season with the Stanford men's basketball program and his first as assistant coach. Elkin spent 2024-25 as assistant recruiting coordinator at Stanford before spending one season at Columbia in 2025-26 as an assistant coach.Elkin arrived at Stanford in 2024 after spending the previous four seasons at Yale as director of basketball operations. Concurrent with his role at Yale, Elkin has served as an assistant coach with Team USA with the under-18 team. He helped lead the American delegation to a gold medal at the 2022 World Maccabiah Games. Matt is also the Executive Director of the Jewish Coaches Association.Prior to his time in New Haven, Elkin served as an assistant coach at the Windward School in Los Angeles, where he helped the program to a 53-15 record over two seasons. He also spent two seasons at Vermont Academy as a varsity assistant coach from 2016-18.Elkin began his coaching career as a student manager at the University of Wisconsin and later served as head manager and student assistant for two seasons at Division III Edgewood College in Madison, Wisconsin. While earning a Master's degree in Sports Leadership from Northeastern in 2016, Elkin served as the graduate manager for the men's basketball team for two seasons.On this episode Mike & Matt discuss his remarkable journey from coaching youth basketball to achieving his dream role at a prestigious institution like Stanford. Throughout our conversation, Matt emphasizes the importance of fostering enjoyment and passion in the game, a principle instilled in him by his early coaches. We delve into his experiences at Yale, where he contributed to three Ivy League championships, and how those formative years shaped his coaching philosophy. Elkin discusses the challenges and opportunities presented by the evolving landscape of college basketball, particularly with respect to the recruitment process amidst the pressures of the NIL era. Matt shares his commitment to nurturing student-athletes, ensuring they thrive both on the court and in their academic pursuits, all while upholding the values that define Stanford's storied legacy in athletics and education.Follow us on Twitter and Instagram @hoopheadspod for the latest updates on episodes, guests, and events from the Hoop Heads Pod.Make sure you're subscribed to the Hoop Heads Pod on Apple, Spotify, or wherever you get your podcasts and while you're there please leave us a 5 star rating and review. Your ratings help your friends and coaching colleagues find the show. If you really love what you're hearing recommend the Hoop Heads Pod to someone and get them to join you as a part of Hoop Heads Nation.Be sure to have pen and paper handy before you listen to this episode with Matt Elkin, Men's Basketball Assistant Coach at Stanford University.Website - https://gostanford.com/sports/mens-basketball https://jewishcoaches.com/Email - mattelkin91@gmail.comTwitter/X - @CoachElkin

Hour 3 of the Bob Rose Show, on the coming appearance by VP JD Vance on ‘The View.' The inspirational story of Vance, coming from Appalachia poverty, where more fall into a life of crime than rise to an Ivy League education and earn status on the national stage. But, why is he setting himself up for liberal abuse from ‘The View?' Plus, all of Friday morning's biggest news stories for 6-12-26.

Filmmaker drew inspiration from Philipstown Lily Weisberg, a 26-year-old filmmaker from New York City, has been directing and producing films in Philipstown since she was a student at Yale. Rare Birds, her most recent short film, was inspired by the natural beauty and "inherent intimacy" of rural Putnam County, she says. She spent many summers in Garrison, riding Metro-North from the city to attend camps at The Depot Theater. Her parents moved to Philipstown while she was in college. Weisberg's 10-minute film premiered at the Tribeca Film Festival on June 5 and will be shown again today (June 12) and Saturday. "It's a festival I've dreamed about having a movie in as long as I've been making movies," she said. In the film, a serial klutz named Jerry (Tony Macht) risks losing his job at a local antique store. "He's like a bull in a China shop," Weisberg said, with a laugh. "He obviously should not be working in an antique store." Jerry is also a camp counselor, and one of the campers, 12-year-old Candice (Zoe Ziegler), is a frequent visitor. She is determined to get Jerry fired so the friends can spend more time together. Their relationship, says Weisberg, is "the kind that can only really exist in a small town. They're both these oddball characters, but they're united because they are similar and from the same place." The film was shot at Bowen Barn, a shop in Stanfordville, but Weisberg and her team scouted antique stores in and near Philipstown and Beacon. "We used what we saw in our set design," she said. "I liked the idea of creating this sort of cocoon for them —a cozy, dark antique store where everything's fragile, but it's kind of desolate." Weisberg directed two previous short films, Studio 210 (2021) and Working Summer (2024), at her parents' home. Her mother's studio and gardens served as inspiration for the former, in which an aspiring artist spends a summer at his friend's mother's studio. "I wanted to make something that used all of this beauty that she'd created," said Weisberg of her mother, Deborah Needleman, a basketmaker. Achieving small-town authenticity has its challenges. Child labor laws limited how long Ziegler could be on set, and the Bowen Barn contains many fragile items that required caution when moving cameras and lights. On the plus side, "the energy is just so good with a crew that lives and works in the Hudson Valley," said Weisberg. "People are happy because they're surrounded by nature and beauty. "The fact of just loving a place comes through in a movie," she says. "I want to work in places that I love and have a relationship to." Rare Birds will be screened in New York City today (June 12) at 8:30 p.m. at Spring Studios (50 Varick St.) and on Saturday at 2:15 p.m. at AMC 19th St. East 6 (890 Broadway). See tribecafilm.com/films/rare-birds-2026. For Weisberg's earlier films, see dub.sh/weisberg-films.

Howie and Harlan discuss healthcare headlines including proposed changes to federal research funding, an outbreak of New World screwworm in Texas cattle, and the debate over free expression after researchers were removed from the American Diabetes Association meeting for distributing an editorial critical of federal science policies. They also examine the future of generic GLP-1 drugs, a new Medicare model for heart failure care, and a court ruling with implications for international physicians practicing in the United States. Show notes: Research Grants NIH: NOT-OD-25-132: Supporting Fairness and Originality in NIH Research Applications Akiko Iwasaki Health & Veritas Episode 192: Akiko Iwasaki: What Have We Learned About Long COVID? Stuart Buck "White House proposes new rules giving political appointees final approval on research grants" U.S. Constitution: Article II Skinny Labeling and the Supreme Court "Supreme Court Upholds Preventive Services Requirement Under ACA" "Supreme Court Rejects Colorado Law Banning 'Conversion Therapy' for L.G.B.T.Q. Minors" Hikma Pharmaceuticals USA Inc. v. Amarin Pharma, Inc. (24-889) "Hikma v. Amarin: Supreme Court Weighs Future of 'Skinny Labeling'" Value-Based Care CMS: Value-Based Care CMS: Hospital Readmission Reduction New World Screwworm CDC: New World Screwworm USDA: New World Screwworm Economic Impact Report USDA: Eradicating New World Screwworm with Sterile Insect Technique American Diabetes Association Meeting "Join the ADA in New Orleans for the 2026 Scientific Sessions" NIH Director Jay Bhattacharya Diabetes Care: "Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now!" "Diabetes researchers ousted from conference after criticizing Trump" H-1B Visas Presidential Proclamation on Restriction on Entry of Certain Nonimmigrant Workers "Federal judge blocks Trump's $100,000 H-1B visa fee" "Health Care Professionals Sponsored for H-1B Visas in the US" Exchange Visitors and the J-1 Classification In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.

The birthright citizenship case and immigration raids have drawn headlines and national attention, but Lucas Guttentag, who teaches immigration law at Stanford and Yale law schools, says some of the Trump administration's most consequential immigration changes are unfolding with far less public scrutiny. Guttentag, one of the nation's leading immigration law experts and founder of the ACLU Immigrants' Rights Project, joins host Professor Pamela Karlan for a wide-ranging conversation about current American immigration policies. Guttentag discusses his time in the Biden administration and compares policies in the first Trump administration with those of the second. He also focuses on the Immigration Policy Tracking Project, an effort he launched in 2017 with law students to document every Trump administration immigration policy, implementation memo, directive, and related legal challenge. The tracker, he explains, is designed to make visible what can otherwise be hard to see: hundreds of policy changes that, taken together, are reshaping the immigration system. The episode examines what these changes mean for immigration courts, bond hearings, temporary protected status, green card applications, and the lawyers challenging the administration in court. One of Guttentag's central points is that immigration is a civil system, not a criminal one, and the distinction matters for anyone trying to understand what is happening now. Links: Lucas Guttentag >>> Stanford Law School page Immigration Policy Tracking Project >>> IPTP page Connect: Episode Transcripts >>> Stanford Legal Podcast Website Stanford Legal Podcast >>> LinkedIn Page Rich Ford >>>  Twitter/X Pam Karlan >>> Stanford Law School Page Stanford Law School >>> Twitter/X Stanford Lawyer Magazine >>> Twitter/X (00:00:00) The Immigration Policy Tracking Project (00:07:33) The Dismantling of the Immigration Court System (00:12:15) "Public Spectacle and Private Terror" — Tactics of Fear  (00:17:32) Asylum, TPS, and the Racial Undercurrent (00:21:51) The Courts Push Back  (00:29:22) What a Rebuilt Immigration System Would Look Like  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Today, I'm thrilled to connect with Rowan Jacobsen. Rowan writes about science, nature, and the world's lesser-explored corners for publications including Harper's, Outside, The Atlantic, Scientific American, Smithsonian, and The New York Times, among others. He is the author of nine books, has lectured at Harvard and Yale, and has appeared on CBS, NBC, and NPR. In today's conversation, we discuss his unique and fascinating new book, In Defense of Sunlight, which explores the nuances surrounding light exposure. We look at the value of sun exposure and vitamin D, and Rowan explains why light acts as a master regulator in the body and how our modern lifestyles may be disrupting our natural biology more than we realize. We examine the effects of shift work, cortisol rhythm dysregulation, and the minimum effective dose of sunlight intensity and exposure, and Rowan breaks down how UVA and UVB wavelengths impact our physiology. We also cover the importance of nitric oxide production, and Rowan shares recommendations from his work. Stay tuned for an eye-opening conversation on why sunlight may be one of the most overlooked foundations of human health. For those who enjoy reading about science, I highly recommend Rowan's book! IN THIS EPISODE, YOU WILL LEARN: Why so many people fear any sun exposure rather than aiming for sensible, moderate exposure How light acts as a master regulator for circadian biology Why does spending most of the day indoors with artificial lighting make it harder to maintain healthy circadian rhythms? How shift work disrupts the body's normal repair processes How cortisol and melatonin work together as part of a coordinated daily rhythm What research shows about cloudy outdoor environments providing higher light levels than most indoor spaces  The differences between how UVA and UVB exposure impact the body How ultraviolet light can trigger nitric oxide release Practical ways to support your circadian health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Rowan Jacobsen On his website Rowan's book, In Defense of Sunlight, will be available online and in bookstores on June 16th 

Healthy skin after 40 starts from within. In this episode of The Women's Vibrancy Code, Maraya Brown sits down with Harvard-trained dermatologist Dr. Mary Alice Mina explores the connection between skin health, nutrition, sleep, hormones, hydration, and healthy aging, and shares practical ways to support vibrant skin and longevity at every stage of midlife.    About Dr. Mary Alice Mina Dr. Mary Alice Mina, MD, FAAD, FACMS is a Harvard-trained, double board-certified dermatologist and dermatologic surgeon. She is the co-owner of Baucom & Mina Derm Surgery in Atlanta and the host of The Skin Real, a globally ranked podcast that breaks down skincare myths and helps people make smarter decisions about their skin health. With nearly two decades of clinical experience, Dr. Mina is known for her thoughtful, science-based approach to skin health, aging, and aesthetic medicine. Through her podcast, educational content, and patient care, she empowers people to simplify skincare, cut through misinformation, and feel confident in their skin at every stage of life. Connect with Dr. Mina Instagram | TikTok |  LinkedIn Website | YouTube  | Apple Podcasts | Spotify    Explore Her Offers RegimenPro Aire Health The Skin Real Store Elm Biosciences   Free Resources: 5 Day Perimenopause Challenge In My Perimenopause Era The Women's Vibrancy Accelerator Trifecta: Your 90-Day Health Reset Ready to take your health to the next level? The Women's Vibrancy Accelerator Trifecta offers deep, personalized support to help you regain control of your energy, hormones, and well-being. This program includes: Three one-on-one calls with Maraya Dutch Plus Test and full assessment Bi-weekly live Q&A sessions Self-paced health portal covering energy, hormones, libido, and confidence   Podcast listeners get an exclusive discount. Use code PODCAST. Learn more and enroll now: https://marayabrown.com/trifecta/ _______________________ Free Wellness Resources Access free tools like the Menstrual Tracker, Adaptogen Elixir Recipes, Two-Week Soul Cleanse, Food Facial, and more. Download now: https://marayabrown.com/resources/ _______________________ Subscribe to The Women's Vibrancy Code Podcast Listen on Apple Podcasts, YouTube, and Spotify. _______________________ Connect with the Show Find us on Facebook,  Linkedin | Website | Tiktok | Facebook Group _______________________ Apply for a Call with Maraya Brown Start your journey with personalized support. Apply here: https://marayabrown.com/call  _______________________ About Maraya Brown Maraya is a Yale and Functional Medicine-trained Women's Health and Wellness Expert (CNM, MSN). She helps women feel energized, confident, and connected to themselves and their lives. With over 25 years of experience, she specializes in energy, hormones, libido, confidence, and deep transformation. _______________________ Disclaimer The content of this podcast is for informational, educational, and entertainment purposes only and does not constitute medical or professional advice. Listeners should consult with a qualified professional before making any health decisions.   This Podcast Is Produced, Engineered & Edited By: Simplified Impact 

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Drop us a note about the podcast. Fear has a way of shrinking your world down to whatever headline is loudest and whatever person seems most powerful. We push back on that impulse by reading Psalm 118 out loud and letting it set the order of operations: God first, refuge first, obedience first. “The Lord is for me, so I will have no fear” isn't sentimental, it's a claim about where courage actually comes from when life gets ugly and trust in people starts to wobble.From there, we move through John 12 as Jesus approaches Passover, Mary anoints His feet, and the crowds celebrate a King who rides in on a donkey. It's a vivid reminder that real worship can look wasteful to cynical eyes, that betrayal often hides behind moral talk, and that God's plan keeps moving even when leaders try to clamp down on it. We also read Proverbs on marriage and speak plainly about responsibility, satisfaction, and faithfulness inside the covenant, plus Proverbs 15 on wisdom, humility, and the kind of words God delights in.We then honor Medal of Honor recipient John Edward Butts and reflect on leadership under fire, before shifting into America's Christian heritage with a look at the stated Christian purposes behind Yale and Princeton. Whether you're here for Bible reading, Christian marriage guidance, faith and culture, or Christian education history, the thread stays consistent: no policy can replace repentance, and no institution can fix what only God can heal.Subscribe for more, share this with someone who needs steadier footing, and leave a review so more listeners can find the show. What part of Psalm 118 do you need to remember most right now?#AmericanHeritage#ChristianNation#AmericanEducation Support the showThe American Soul Podcasthttps://www.buzzsprout.com/1791934/subscribeCountryside Book Serieshttps://www.amazon.com/Countryside-Book-J-T-Cope-IV-ebook/dp/B00MPIXOB2 

In this episode, Greg interviews legendary foreign correspondent Denis Gray about his memoir, Lost Horizons. Denis details his fascinating life story, beginning with his family's escape from communist Czechoslovakia and his father's subsequent intelligence work for the CIA. After graduating from Yale, Gray served in the U.S. Army during the Vietnam War, an intense experience that inspired his transition into journalism with the Associated Press. The next few decades saw Denis covering critical global conflicts, focusing heavily on the Indochina wars. He highlights the extreme challenges of reporting on the Khmer Rouge genocide from the Thai-Cambodian border, noting how a lack of visual media at the time left these historical atrocities largely forgotten by the wider world. Greg and Ed then discuss the immense psychological weight of Gray's memories. Ed expresses a mix of awe and relief, admitting he is glad he never had to face such immense dangers himself. Ultimately, both hosts agree that Gray's career represents a rare, vanishing breed of war correspondence, emphasizing the vital importance of preserving these profound, first-hand historical accounts. For a more visual discussion, see a video of Dennis' book launch and Q&A at the Foreign Correspondent's Club here in Bangkok.  

Nörobilim çalışmalarında "hasta"yı bir "özne"ye dönüştürmek niçin önemli? İlaçlı tedavi yerine önleyici tedavilerin rolü ne, ne olmalı? Konuğumuz Yale Üniversitesi nörobilimcilerinden Prof. Şule Tınaz anlatıyor.

AI ethicist Jess Morley: these chatbots are giving medical advice — so regulate them as medical devices. Part of The Agentic Patient, a Faces of Digital Health series on how patients actually use AI — which tools, which prompts, which safeguards. In this episode, host Tjaša Zajc sits down with Dr Jess Morley, Associate Research Scientist at the Yale Digital Ethics Center and a former AI subject-matter expert at the UK Department of Health and Social Care, for a clear-eyed account of where health AI is going wrong — and how to use it well anyway. Morley argues we systematically overestimate what these tools can do and underestimate the harm. She makes the case for "skeptical optimism," explains why bioethics principles built for one-to-one care break down against many-to-many AI harms, and reframes ambient scribes as inference engines rather than transcription services — with real consequences for coding, billing and patient records. Then she gets practical: the guardrails, prompts and habits patients (and clinicians) can use today. Guest: Dr Jessica Morley — Associate Research Scientist, Yale Digital Ethics Center; formerly UK Department of Health and Social Care and the Bennett Institute, University of Oxford. What the conversation covers: - Why "skeptically optimistic" is the honest position on health AI - AI adoption as "a hammer looking for nails" — and what needs-led design would look like instead - OpenEvidence, EU rules and the question of regulatory capture - The DeepMind–Royal Free case and why law alone isn't enough - Beneficence, non-maleficence, autonomy, justice — and where they fail for AI - Ambient AI scribes, miscoding, billing inflation and phantom tests - Paid vs free models and the widening access gap - The "ask why" rule and knowing when to walk away from a chatbot - Red-teaming your own assumptions and playing models off each other - Building a personal "harness" with skills so AI works from your history - The last-mile problem and the case for regulating LLMs as medical devices - Whether AI is narrowing how clinicians think Chapters: 02:50 — Intro: The Agentic Patient and the case for skeptical optimism 05:52 — "A hammer looking for nails": adoption pressure without a plan 07:25 — OpenEvidence, EU rules and regulatory capture 09:42 — The DeepMind–Royal Free lesson: why law needs ethics 13:29 — The bioethics principles and what they were built to do 19:40 — Autonomy, consent and the ambient-scribe problem 21:49 — Scribes as inference engines: miscoding, fraud and phantom tests 29:06 — Paid vs free models and the access gap 33:25 — Using AI safely: the "ask why" rule 37:38 — Knowing when to walk away: engagement design and degradation 44:58 — Red-teaming and playing models off each other 49:00 — Harnesses and skills: making the model work for you 51:38 — The last-mile problem and regulating AI as a medical device 58:00 — Does AI narrow the clinician's mind? The Agentic Patient series: https://www.facesofdigitalhealth.com/agentic-patient-blog Website: https://www.facesofdigitalhealth.com Newsletter: https://fodh.substack.com LinkedIn: https://www.linkedin.com/company/faces-of-digital-health

What Exactly Is a Reverse Mortgage? Episode 387 – We hear so much talk these days about reverse mortgages. Are they worth looking into? For some people the answer is yes, but only if certain conditions are met. More SML Planning Minute Podcast Episodes Transcript of Podcast Episode 387 Hello, this is Bill Rainaldi, with another edition of Security Mutual's SML Planning Minute. In today's episode: so what exactly is a reverse mortgage? It's hard to miss all the talk these days about reverse mortgages as an income tool for retirees. Some experts like them, some experts don't. But what are they and how do they work? For many Americans, their biggest asset is the equity they have in their home. Some might not have saved much for retirement. But after years, perhaps decades, of living in the same home, they've built up their home equity through appreciation and amortization of their mortgage. When they look at their balance sheets, that becomes their biggest plus. What options do people have if they get to retirement age, have limited retirement savings, and realize that Social Security just isn't going to be enough? A reverse mortgage is one possible answer. A reverse mortgage is available for homeowners aged 62 and over. It is a way to fund retirement by borrowing against the equity you've built up in your home. The more home equity you have, the better. But it's certainly not for everyone. A reverse mortgage is not the same thing as a home equity line of credit, or HELOC. It's called a reverse mortgage because instead of you making monthly payments to the bank, the bank makes monthly payments to you. The income you get from a reverse mortgage is generally not taxable. You can use that income as needed to cover monthly expenses, including such things as home maintenance, property taxes, or, if needed, home health care expenses.[1] A reverse mortgage isn't free. The amount you owe against your house, which includes the principal and accruing interest, increases as you receive your monthly payments. So over time, your home equity decreases. You are essentially trading a little bit of your home equity every month for current income. Note that you typically don't have to repay the mortgage as long as you continue to use the home as your primary residence. But if you decide to sell your house or move out, the full balance will become due. If you die before you move out, in most cases your executor will sell the home and use the proceeds to pay back the accumulated reverse mortgage debt.[2] Reverse mortgages generally come in three different varieties. The first, and by far the most common, are loans overseen by the Federal Housing Authority. These are known as Home Equity Conversion Mortgages or HECMs. The homeowner has discretion over what to use the funds for, but before closing, they must meet with a counselor approved by the Department of Housing and Urban Development. This one requirement is designed to help curb fraud and abuse. HECMs account for approximately 95 percent of all reverse mortgages.[3] They are more regulated than other types of reverse mortgages and offer some extra protection. For one thing, neither you nor your heirs will ever owe more than the house is worth, even if it goes down in value. And if your lender goes out of business, the federal insurance program guarantees that you will still receive your monthly payments.[4] The maximum you can borrow under the federal program in 2026 is $1,249,125.[5] You will typically need to have at least 50 percent equity in your home (based on appraised value) to qualify. Reverse mortgages typically have adjustable interest rates. Note that the income from a reverse mortgage usually comes in the form of a monthly payment, but that's not a requirement. It can also be in a lump sum. The two other less common types of reverse mortgages are “single-purpose reverse mortgages,” which are backed by a nonprofit organization or a state or local government, and “proprietary reverse mortgages,” which are offered by private organizations without any government backing. Reverse mortgages have had a somewhat mixed reputation over the years. For one thing, the fees involved can be considerable. A reverse mortgage typically has origination fees, mortgage insurance premiums, closing costs and monthly servicing fees, all of which add up.[6] And there are still some scams out there. Some fraudsters will entice vulnerable seniors with misleading or fraudulent claims. One of those might be when a potential intermediary tries to get you into a reverse mortgage, then uses the money for some sort of “investment opportunity” that they control. They will then typically end up pocketing some of your home's equity themselves.[7] One way to avoid scams like this is to start with a trusted financial advisor or your current lender. Are there other potential solutions? Of course. The most obvious is, if possible, to save more at an earlier age and allow compound interest to work its magic. But for a lot of people, that's just not possible. For some people, a reverse mortgage is another option. There are caveats, but this may be a good choice in the right circumstances. A reverse mortgage is not the perfect solution, but for some, depending on their situation, it may be the most viable one. [1] Equifax Life Stages. “What is a Reverse Mortgage and How Does it Work?” Equifax.com. https://www.equifax.com/personal/education/credit/score/articles/-/learn/reverse-mortgage/ (accessed May 19, 2026). [2] Id. [3] Yale, Aly J. “What Is a Reverse Mortgage?” AARP.org. https://www.aarp.org/money/personal-finance/reverse-mortgage-guide/ (accessed May 19, 2026). [4] Id. [5] Johnson, Jamie. “HECM Loan Limits: What They Are and How They Work in 2026.” Themortgagereports.com. https://themortgagereports.com/124868/hecm-loan-limits (accessed May 20, 2026). [6] Miller, Peter G. “Reverse mortgage pros and cons.” Bankrate.com. https://www.bankrate.com/mortgages/reverse-mortgage-pros-and-cons/#cons (accessed May 20, 2026). [7] Goff, Kacie. “Reverse mortgage scams: What they are and how to avoid them.” Bankrate.com. https://www.bankrate.com/mortgages/reverse-mortgage-scams/#common-scams (accessed May 20, 2026). More SML Planning Minute Podcast Episodes This podcast is brought to you by Security Mutual Life Insurance Company of New York, The Company That Cares®. The content provided is intended for educational and informational purposes only. Information is provided in good faith. However, the Company makes no representation or warranty of any kind regarding the accuracy, reliability, or completeness of the information. The information presented is designed to provide general information regarding the subject matter covered. It is not to serve as legal, tax or other financial advice related to individual situations, because each individual's legal, tax and financial situation is different. Specific advice needs to be tailored to your situation. Therefore, please consult with your own attorney, tax professional and/or other advisors regarding your specific situation. To help reach your goals, you need a skilled professional by your side. Contact your local Security Mutual life insurance advisor today. As part of the planning process, he or she will coordinate with your other advisors as needed to help you achieve your financial goals and objectives. For more information, visit us at SMLNY.com/SMLPodcast. If you've enjoyed this podcast, tell your friends about it. And be sure to give us a five-star review. And check us out on LinkedIn, YouTube and Twitter. Thanks for listening, and we'll talk to you next time. Tax laws are complex and subject to change. The information presented is based on current interpretation of the laws. Neither Security Mutual nor its agents are permitted to provide tax or legal advice. The applicability of any strategy discussed is dependent upon the particular facts and circumstances. Results may vary, and products and services discussed may not be appropriate for all situations. Each person's needs, objectives and financial circumstances are different, and must be reviewed and analyzed independently. We encourage individuals to seek personalized advice from a qualified Security Mutual life insurance advisor regarding their personal needs, objectives, and financial circumstances. Insurance products are issued by Security Mutual Life Insurance Company of New York, Binghamton, New York. Product availability and features may vary by state.​ SubscribeApple PodcastsSpotifyAndroidPandoraby EmailTuneInDeezerRSSMore Subscribe Options

¿Por qué cuando me enojo respiro de una manera? ¿Y cuando doy un abrazo respiro de otra?… La respiración es la puerta de entrada para manejar las emociones y la mente. Martín comparte sobre el Sudarshan Kriya, una técnica de respiración específicamente diseñada para reducir el estrés, incidir en los niveles de cortisol, mejorar la salud y permitir explorar capas más profundas de nuestra experiencia humana.¡Activa tu membresía hoy!: ⁠⁠www.radiosemilla.com/membresia Proyecto aliado: Yakunina Certificado de Diseño en Permacultura 2026, $50 de descuento para miembros de Radio Semilla! https://www.yakunina.com/cdp2026/Curso del Arte de Vivir en Quito, Ecuador.

California's housing crisis has pushed families, investors, and homeowners to rethink what housing can look like.In this episode of ChangeMakers, Katie Goar sits down with Whitney Hill, co-founder and CEO of SnapADU, to explore how accessory dwelling units, better known as ADUs, are changing the housing landscape across San Diego and beyond.Whitney shares how SnapADU launched during the 2020 shutdown, why California's regulatory changes created a massive opportunity, and how her company has now completed more than 100 detached ADU builds.The conversation covers:• The real drivers behind ADU demand• Why families are embracing multi-generational living• How homeowners are using ADUs for wealth building• The biggest bottlenecks slowing housing development• Why permitting and utility regulations remain a challenge• The future of affordable housing in California• What most people misunderstand about ADUsWhitney also explains why the most successful ADU projects focus on quality of life, thoughtful design, and long-term planning instead of simply maximizing density.If you're interested in affordable housing, real estate investing, urban development, entrepreneurship, or the future of housing policy, this episode delivers practical insight into one of the fastest-growing housing trends in America.Subscribe for more conversations with leaders creating real-world solutions in housing, healthcare, business, and community development.Topics Covered / What You'll LearnWhat an ADU actually isWhy California changed ADU lawsHow Snap ADU grew during COVIDThe economics behind ADU investingWhy multi-generational housing is growingThe biggest construction and permitting bottlenecksHow homeowners use ADUs to offset mortgage costsThe future of housing density in CaliforniaWhy San Diego became a hotspot for ADUsHow thoughtful housing design improves quality of lifeThe hidden complexity behind “simple” ADU buildsHow Whitney Hill built a niche construction companyTimestamps00:00 Intro00:12 Meet Whitney Hill of Snap ADU01:00 How California's ADU law changes created opportunity02:40 The story behind the name Snap ADU03:30 Why San Diego became an ADU hotspot05:10 Who is building ADUs today?06:30 Community concerns around density and parking08:25 Housing demand and city capacity09:45 Why California has embraced ADUs11:00 ADUs as a wealth-building tool12:15 Multi-generational living success stories14:20 The realities of running an ADU construction company16:20 The biggest bottlenecks slowing housing growth17:45 ADU design trends and creative layouts19:15 Whitney Hill on leadership and entrepreneurship21:00 Yale, NYU, and finding her professional niche22:40 Snap ADU's future growth strategy24:30 Can ADUs help affordable housing?26:20 Closing thoughts

COLLEGE APPLICATION TRAINING CAMP — JULY 2026

“The United States has conducted an unusually ideological foreign policy, an unusually economic foreign policy, and an unusually democratic foreign policy. These three features have been present from the eighteenth century to the present.” — Michael Mandelbaum Is there an “American way” of foreign policy? Does that make the now almost 250 year-old republic unique? Michael Mandelbaum, author of The American Way of Foreign Policy: Ideology, Economics, Democracy, says yes and no. America is exceptional. But that exceptionalism is unexceptional. Mandelbaum says that American foreign policy over the last 250 years has been unusually ideological, economic, and democratic. Foreign policy realists say great powers all behave the same way. Mandelbaum, as an idealist, says: not America. Uniquely in world history, he says, America has pursued its principles overseas without prioritising its political, economic, or military self-interest. And yet The American Way of Foreign Policy isn't triumphalist. Mandelbaum opposed NATO expansion in the 1990s. He was in the anti-Vietnam marches as a Harvard student in the Sixties. Nor is he partial to demonstrations of overt nationalism. His July 4 plans, for example, are to watch baseball. As a lucky man in a fortunate Republic, what better way to celebrate 250 years of independence than to enjoy its national pastime? Five Takeaways •       Three Distinctive Features: Ideological, Economic, Democratic: Mandelbaum's thesis: American foreign policy has differed from the foreign policies of other countries in three enduring ways. First, ideological: political ideas and the effort to spread them have been more important to America than to other powers. Second, economic: America has used economic instruments to achieve political goals — trade, aid, sanctions — rather than the imperial model of using political power for economic gain. Third, democratic: American public opinion has always had greater influence over foreign policy than in other countries. For almost all other countries, for most of their histories, foreign policy was the preserve of a small elite. That was never true of the United States. •       Idealist and Realist: Both Apply: Andrew invokes Kenneth Waltz and the realist tradition, which argues that great powers always behave the same way regardless of their self-image. Mandelbaum's response: realism fits American foreign policy up to a point. America has fought twelve significant wars and has not been oblivious to military power. But it has also conducted idealist foreign policies that cannot be explained by realism — policies driven by its liberal political ideas rather than its material interests. The distinctive feature of American foreign policy is not that it ignores realism, but that it goes beyond realism in ways that other great powers have not. •       NATO Expansion: Mandelbaum's One Big Regret: In the 1990s, Mandelbaum was opposed to the expansion of NATO, alongside George Kennan — one of the architects of Cold War containment. His fear: it would do a lot to alienate Russia. He acknowledges that he cannot blame NATO expansion explicitly for the Russian attack on Ukraine. But he notes that the fear was reasonable and that, as he puts it, alas, it has come to pass. He does not think that the Russian attack was inevitable or that NATO caused it. But he does think the warning was worth issuing and that it deserved more serious consideration than it received. •       Vietnam and the Antiwar Movement: Was It Counterproductive? As a graduate student at Harvard under Stanley Hoffmann, Mandelbaum was opposed to Vietnam and took part in marches. He has since revised his views — not on whether Vietnam was a mistake (it was) but on whether the antiwar movement had any positive effect on the course of policy. His conclusion: it probably didn't, and may have been perverse. Nixon used the antiwar movement as a foil. The war ended because most Americans decided it was costing too much in American lives — not because the goals were wrong. That was the democratic aspect of American foreign policy in action. •       Israel, Gaza, and the American Way: Andrew suggests that Israel has been able to push America around, and that this is “un-American.” Mandelbaum pushes back firmly. America supports Israel for two reasons: strategic advantage (Israel as a bulwark against threats to American interests in the Middle East) and shared values (Israel is the only country in the region that shares American political values). When interests diverged — the 1980s anti-aircraft arms sale, Obama's Iran deal — America went its own way. The reverse is also true: America doesn't have the capacity to push Israel around in Gaza, because for Israel these are matters of national survival. About the Guest Michael Mandelbaum is the Christian A. Herter Professor Emeritus of American Foreign Policy at the Johns Hopkins University School of Advanced International Studies. He previously taught at Harvard, Columbia, and the US Naval Academy, and was a Senior Fellow at the Council on Foreign Relations. He holds a BA from Yale, an MA from King's College Cambridge, and a PhD from Harvard. He is the author or co-author of thirteen books, including The American Way of Foreign Policy: Ideology, Economics, Democracy (Oxford University Press, April 2026) and The Four Ages of American Foreign Policy: Weak Power, Great Power, Superpower, Hyperpower. He lives in the Washington DC suburbs. References: •       The American Way of Foreign Policy: Ideology, Economics, Democracy by Michael Mandelbaum (Oxford University Press, April 2026). •       The Four Ages of American Foreign Policy: Weak Power, Great Power, Superpower, Hyperpower by Michael Mandelbaum — referenced in the conversation. •       Kenneth Waltz and the realist school of international relations — referenced at the opening. •       Ernst Haas and the idealist school — referenced at the opening; Andrew's teachers at Berkeley. •       George Kennan — referenced as Mandelbaum's fellow opponent of NATO expansion in the 1990s. •       Stanley Hoffmann — Mandelbaum's Harvard PhD supervisor, referenced at the close. About Keen On America Nobody asks more awkward questions than the Anglo-American writer and filmmaker Andrew Keen. In Keen On America, Andrew brings his pointed Transatlantic wit to making sense of the United States — hosting daily interviews about the history and future of this now venerable Republic. With nearly ...

Discover how the Alliance for Equality of Blind Canadians is bridging the technology knowledge gap for blind and partially sighted users. Marcia Yale, AEBC's national president, shares actionable insights on teaching foundational tech skills, addressing accessibility barriers, and empowering lifelong learning. In this episode of Double Tap, Steven Scott and Shaun Preece welcome Marcia Yale, national president of the Alliance for Equality of Blind Canadians (AEBC). Marcia reflects on her early tech journey in the 1980s, learning DOS and mainframe navigation, and how that early foundation shaped her love of technology. The discussion explores the digital knowledge gap facing blind and partially sighted individuals, particularly those who were introduced to tech later in life or without proper foundational training. Marcia highlights the challenges of navigating modern devices like smartphones and banking apps, the lack of accessible and clear user manuals, and the gaps left by inconsistent training resources. Key topics include the importance of teaching from the basics, the role of peer support and trainer certification, and how AI-driven tools could personalise tech education in the future. They also touch on the responsibility of tech companies, the potential need for legislation, and why fostering curiosity and confidence is essential to ensure everyone can participate in today's digital world. Relevant Links Alliance for Equality of Blind Canadians (AEBC): https://www.blindcanadians.ca AEBC YouTube Channel – Tech Training Tuesdays: https://www.youtube.com/@BlindCanadians ----Follow on:YouTube: https://www.doubletaponair.com/youtubeX (formerly Twitter): https://www.doubletaponair.com/xInstagram: https://www.doubletaponair.com/instagramTikTok: https://www.doubletaponair.com/tiktokThreads: https://www.doubletaponair.com/threadsFacebook: https://www.doubletaponair.com/facebookLinkedIn: https://www.doubletaponair.com/linkedinSubscribe to the Podcast:Apple: https://www.doubletaponair.com/appleSpotify: https://www.doubletaponair.com/spotifyRSS: https://www.doubletaponair.com/podcastiHeadRadio: https://www.doubletaponair.com/iheartAbout Double TapHosted by the insightful duo, Steven Scott and Shaun Preece, Double Tap is a treasure trove of information for anyone who's blind or partially sighted and has a passion for tech. Steven and Shaun not only demystify tech, but they also regularly feature interviews and welcome guests from the community, fostering an interactive and engaging environment. Tune in every day of the week, and you'll discover how technology can seamlessly integrate into your life, enhancing daily tasks and experiences, even if your sight is limited."Double Tap" is a registered trademark of Double Tap Productions Inc. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How should we understand the relationship among sound, consciousness and a healthy mind? It has to do with the power of connection, not just to other people but the world around us. In this episode of the Hacking Longevity series, Kara talks to Dr. AZA Allsop, an artist and psychiatrist who runs a lab at Yale that studies how music and sound can affect mental well-being and the power of connections we feel with other people.  Later, she talks to science journalist Michael Pollan, author of A World Appears: A Journey Into Consciousness. He goes deep on what makes the brain work, and he has some very interesting thoughts on whether machines could become sentient. Questions? Comments? Email us at on@voxmedia.com or find us on YouTube, Instagram, TikTok, Threads, and Bluesky @onwithkaraswisher. Learn more about your ad choices. Visit podcastchoices.com/adchoices

America Out Loud PULSE with Dr. Randall Bock – Rob Henderson's encounter with Theodore Dalrymple reveals how elite ideas travel from universities into culture, medicine, addiction policy, and family life. Through foster care, Yale, primary care, and prison psychiatry, the discussion shows why responsibility, norms, and cultural guardrails still shape poverty, dysfunction, and recovery more than theory admits...

From birthright citizenship to the independence of federal agencies, the Supreme Court is poised to decide a series of cases that could redefine the balance of power in Washington. Yale legal scholar and New York Times Magazine staff writer Emily Bazelon joins Ian Bremmer to assess what's at stake and whether the judiciary remains an effective check on presidential authority. Bazelon argues that Trump's effort to end birthright citizenship is unlikely to succeed, but says other pending cases involving the Federal Reserve and the Federal Trade Commission could significantly expand presidential control over agencies that Congress intentionally designed to operate independently. "I think it's very likely the court will rule in the president's favor," she says of the FTC case. The conversation also examines the Court's recent decisions on tariffs and voting rights, including a ruling that further weakened protections against partisan gerrymandering. Bazelon argues that the consequences extend beyond individual cases, contributing to a broader perception that the Court is becoming increasingly political. Yet despite declining public trust, Bazelon sees reasons for cautious optimism. While Congress has largely failed to constrain executive power, she argues that the judiciary, particularly the lower courts, has repeatedly pushed back against actions that exceed legal authority. The bigger question is whether those guardrails will continue to hold as the Court confronts some of the most consequential constitutional disputes still ahead. Subscribe to the GZERO World with Ian Bremmer Podcast on Apple Podcasts, Spotify, or your preferred podcast platform, to receive new episodes as soon as they're published. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

America Out Loud PULSE with Dr. Randall Bock – Rob Henderson's encounter with Theodore Dalrymple reveals how elite ideas travel from universities into culture, medicine, addiction policy, and family life. Through foster care, Yale, primary care, and prison psychiatry, the discussion shows why responsibility, norms, and cultural guardrails still shape poverty, dysfunction, and recovery more than theory admits...

From birthright citizenship to the independence of federal agencies, the Supreme Court is poised to decide a series of cases that could redefine the balance of power in Washington. Yale legal scholar and New York Times Magazine staff writer Emily Bazelon joins Ian Bremmer to assess what's at stake and whether the judiciary remains an effective check on presidential authority. Bazelon argues that Trump's effort to end birthright citizenship is unlikely to succeed, but says other pending cases involving the Federal Reserve and the Federal Trade Commission could significantly expand presidential control over agencies that Congress intentionally designed to operate independently. "I think it's very likely the court will rule in the president's favor," she says of the FTC case. The conversation also examines the Court's recent decisions on tariffs and voting rights, including a ruling that further weakened protections against partisan gerrymandering. Bazelon argues that the consequences extend beyond individual cases, contributing to a broader perception that the Court is becoming increasingly political. Yet despite declining public trust, Bazelon sees reasons for cautious optimism. While Congress has largely failed to constrain executive power, she argues that the judiciary, particularly the lower courts, has repeatedly pushed back against actions that exceed legal authority. The bigger question is whether those guardrails will continue to hold as the Court confronts some of the most consequential constitutional disputes still ahead. Subscribe to the GZERO World with Ian Bremmer Podcast on Apple Podcasts, Spotify, or your preferred podcast platform, to receive new episodes as soon as they're published. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We need to talk about the "creator economy" and the stylish influencers pushing disinformation and misinformation directly into our feeds. The more glossy you are, the more attention you get–and attention is the new currency. That is the same ethos of the princess-haired women swanning around Mar-a-Lago. It's a deliberate dumbing down of society. When gloss replaces the time-intensive grind of investigative journalism, the autocrats and oligarchs who push this strategy distract and confuse us, and ensure important voices who can't win a Sephora Hunger Games get shut out.  In this week's bonus show, Gaslit Nation also covers the chilling expansion of America's police state, focusing on the horrifying conditions at the Delaney detention center in New Jersey. Inmates are on hunger strike to demand basic human rights, mirroring the brutal history of political prisoners under Stalin's regime. We must raise our voices, pressure our elected officials (like Governor Mikie Sherrill), and refuse to look away. Do not let the Mar-a-Lago face creator economy and the attention-hungry gatekeepers confuse and wear you down. Stay grounded in your moral force and amplify the truth. Listen to the full episode on Patreon and support our independent journalism. Shape the show and raise your voice at the Gaslit Nation Salon Monday at 4 PM Eastern. Look out for exciting announcements this coming Monday with a special sneak peak exclusively for our Patreon supporters. Can't make it? Listen to the recording later only on Patreon.com/Gaslit. Thank you to everyone who supports the show.  Show Notes: Opening clip: Dr. Jared Cooney Horvath & EdTech https://www.youtube.com/shorts/dFgGnY87MGw Clip: Editor Sara Hadir spreading Ryan Grim's disinformation https://www.instagram.com/reel/DYxFSFvIvfL/?utm_source=ig_web_copy_link&igsh=NTc4MTIwNjQ2YQ== Watch Andrea Chalupa's journalistic thriller, Mr. Jones https://www.samuelgoldwynfilms.com/mr-jones/# Bloodlands: Europe Between Hitler and Stalin by Timothy Snyder https://bookshop.org/p/books/bloodlands-europe-between-hitler-and-stalin-timothy-snyder/8fa8bc938f216251?ean=9781541600065&next=t On Tyranny: Twenty Lessons from the Twentieth Century by Timothy Snyder https://www.penguinrandomhouse.com/books/558051/on-tyranny-by-timothy-snyder/ Orwell and the Refugees: The Untold Story of Animal Farm by Andrea Chalupa https://www.amazon.com/Orwell-Refugees-Untold-Story-Animal-ebook/dp/B007JNKF5G "They raped every German female from eight to 80" by Antony Beevor in The Guardian https://www.theguardian.com/books/2002/may/01/news.features11 Go Back to Where You Came From: And Other Helpful Recommendations on How to Become American by Wajahat Ali https://www.porchlightbooks.com/products/go-back-to-where-you-came-from-wajahat-ali-9781324050322 Listen to Andrea's sweeping discussion with Wajahat Ali on his Substack show, The Left Hook https://substack.com/@gaslitnation/note/p-200496672?utm_source=notes-share-action&r=2mrjsl Watch the classic investigative journalism film, Spotlight https://www.youtube.com/watch?v=zPZhUM8VlpQ Ryan and Emily DEBATE: Did Soviets END The Holocaust? https://www.youtube.com/watch?v=tJuwsu109YM Laurie Santos, professor at Yale, on how students today just stare at their phones https://www.instagram.com/p/DZJUBPCHyM4/?utm_source=ig_web_copy_link&igsh=NTc4MTIwNjQ2YQ%3D%3D The toll on press covering Delaney Hall https://bsky.app/profile/marisakabas.bsky.social/post/3mnarxbejw22l Learn more about the hunger strike and protests at the Delaney Hall detention center in New Jersey https://www.theguardian.com/commentisfree/2026/jun/02/ice-detention-camp-delaney-hall Contact Representative Mikie Sherrill to demand action on Delaney Hall https://sherrill.house.gov/contact Sign up for the Gaslit Nation Patreon to attend the upcoming songwriting workshop with Leslie Nuss on June 22n at 4pm ET and access the exclusive Monday Salons https://www.patreon.com/gaslit  

My guest today is Charles Ellis, founder of Greenwich Associates, longtime member of Yale's investment committee, and author of more than 20 books, including the classic Winning the Loser's Game. In today's episode, Charley reflects on writing the first major book on share repurchases 50 years ago, when the idea was so foreign that Goldman mailed it to 1,000 corporations as a “legitimizer.” Charley also walks us through his new book, Great American Investments: A History of the Bold Initiatives that Shaped a Nation, covering 14 audacious public investments from the Louisiana Purchase to the Marshall Plan. He explains how each came down to one or two obsessed individuals, why Alaska turned out to be the bargain of the century, and how Frances Perkins muscled Social Security into law. As the episode winds down, he shares the lunch with Sandy Gottesman in the early 1970s that led him to buy Berkshire Hathaway at $700 a share — and hold it ever since. (0:00) Starts (1:54) Charley on stock buybacks (8:06) Current state of investing and behavioral economics (11:37) Advice for young investors and long-term strategies (16:41) Charley's new book: Great American Investments: A History of the Bold Initiatives that Shaped a Nation (25:42) The origins of social Security (32:46) American entrepreneurship (36:43) Will AI be the next great American investment? (42:34) Most memorable investment ----- Sponsor: ⁠Ivy Invest ⁠- To learn more about Ivy Invest's SEC-registered endowment-style fund, view the prospectus, and learn how to invest, visit ⁠ivyinvest.co/fund ----- Follow Meb on X, LinkedIn and YouTube For detailed show notes, click here To learn more about our funds and follow us, subscribe to our mailing list or visit us at cambriainvestments.com ----- Follow The Idea Farm: X | LinkedIn | Instagram | TikTok ----- Interested in sponsoring the show? Email us at Feedback@TheMebFaberShow.com ----- Past guests include Ed Thorp, Richard Thaler, Jeremy Grantham, Joel Greenblatt, Campbell Harvey, Ivy Zelman, Kathryn Kaminski, Jason Calacanis, Whitney Baker, Aswath Damodaran, Howard Marks, Tom Barton, and many more.  ----- Meb's invested in some awesome startups that have passed along discounts to our listeners. Check them out here!  -----Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Learn more about your ad choices. Visit megaphone.fm/adchoices

Jonathan Peterlin and Nick Wilson review a dad joke made to Cynthia Frelund regarding the Cleveland Browns. They also engage in a debate about the implications of wearing Ivy League apparel, sharing anecdotes about Chris Fedor and Kevin Love. 01:03 - Cynthia Freeland Dad Joke 03:04 - Wearing Ivy League Apparel 11:38 - Caller Ivy League Stories

Send us Fan MailHoy revisaremos la historia de una canción que parece tener sentido, pero que no dice nada, es solo ruido con forma de palabras. Eso genera una pregunta inquietante ¿cómo podemos distinguir entre un idioma que no conocemos, un mensaje en código o algo que sencillamente no tiene sentido? Un antiguo libro manuscrito en piel de animal ha desafiado a lingüistas y criptógrafos, profesionales y aficionados, y todavía no sabemos si es una broma elaborada, un código o el último registro de un idioma desconocido. Support the show

Welcome back to Feel-Good Fridays. This week, host Aislyn Greene and producer Nikki Galteland are joined by Afar executive editor Kathrine LaGrave—and the three of them are ready to carry you into the weekend a little lighter, with stories about line dancing, travel with your dog, and the surprisingly simple science of being happy. The happy news Country line dancing is having a queer renaissance. Kathrine shares the story of Stud Country, a New York–based group offering country dancing parties and classes rooted in queer cowboy culture—open to everyone, from regulars to curious first-timers. It's getting a whole lot easier to travel with your dog. Nikki reports that searches for pet-friendly travel are up year-over-year, and a new wave of hotels isn't just tolerating four-legged guests—they're actively celebrating them, with welcome treats, room amenities, dog spas, and yes, an official Director of Pet Relations. Aislyn brings us back to Yale happiness researcher Laurie Santos, who went viral for teaching the most popular course in the university's history—and whose 2026 take on happiness comes down to one thing: more friction, more connection, less optimization. Travel, she argues, is one of the best tools we still have for getting out of our own way. Plus: a spirited debate about cowboy boot colors, a Yappy Hour proposal, and a vision for the ultimate Feel-Good Friday field trip—all dogs welcome. CHAPTERS 00:00:00 Welcome to Feel-Good Friday 00:01:00 Boots, Belonging, and Stud Country 00:05:45 The Great Boot Color Debate 00:06:00 The Happiness Researcher You Need to Hear 00:10:00 Dogs Welcome: The New Pet-Friendly Hotel Era 00:14:30 Yappy Hour and Other Good Ideas Learn more about your ad choices. Visit megaphone.fm/adchoices

Season 2 of Shared Humanity: The humans behind the headlines, hosted by Yale School of Public Health community scholar Nelba Márquez-Greene, is here. This season will highlight people who have dedicated their work to gun violence prevention, starting with members of the Yale School of Public Health firearm injury prevention team: Kerri Raissian, MPA, PhD, Magdalena Cerda, DrPH, MPH '99, and Chris Morrison, MPH, PhD. They discuss the landscape of firearm injury prevention at Yale and across the country, building trust among impacted communities, and using science for good.

The UK, Ireland, France, Spain, and Portugal shattered their May heat records last week. Scenes reminiscent of high summer arrived months early, across Western Europe. And like all extreme weather events, there was a human toll. Infrastructure under strain, health services stretched, and lives lost. But as records fell, the political conversation was moving in the other direction. Former UK Prime Minister Tony Blair published a lengthy essay calling on the government to halt its net zero acceleration and prioritise cheap energy. Rory Stewart made a similar case on The Rest is Politics, invoking AI data centres and industrial competitiveness. Both are figures from the centre of British politics. Neither is a climate denier. So what's happening? This week, Tom Rivett-Carnac and Christiana Figueres sit with this dissonance. They ask what it means when hopelessness becomes self-sustaining, a cultural condition as much as a feeling. They ask whether grief, properly faced, might be what unlocks action rather than foreclosing it. And they look at the history of transformations that began long before success seemed likely.Is the real crisis not just the climate, but one of agency? And what does it take to act with conviction when outcomes are genuinely uncertain?Learn More:☀️ See Severe Weather Europe's recap of the historic heat dome across Europe

Have you ever noticed how hard it is to step away from your phone… even when your  mind and body is asking for a break?The texts, notifications, social media scrolling, and constant pressure to respond to that email can leave you  feeling wired, distracted, and disconnected from yourself. Your mind may say, “Just one more thing,” while your body is quietly tightening, bracing, or whispering that it needs space.And if you've been pushing through for years — caring for everyone else, managing work, family, caregiving, and the invisible weight of modern life — you are not broken. Your body may simply be responding to a world that rarely rewards you how to pause.In this episode, I sit down with Dr. Mary Donohue, founder and CEO of the Digital Wellness Center, whose work blends neuroscience, behavior, and technology. After living with chronic leukemia, caregiving stress, and surviving a heart attack, Mary began looking more closely at digital wellness and how constant connection affects the brain, body, and our ability to pause.Together, we talk about digital overload, micro breaks, nervous system regulation, social media anxiety, and stress-related illness. Mary shares why even a small pause can help your body settle and give you more space before you respond.In this episode, you'll learn:Why midlife women may be especially vulnerable to chronic stress How women over 50 can begin noticing the subtle body cues they've learned to overrideWhat micro breaks can offer when your mind and body feel overstimulatedHow social media anxiety can quietly shape your mood, focus, and sense of calmHow a simple 3 minute micro break can help you regulate you emotional well-being.The connection between technology and mental health in our everyday choicesHow your nervous system staying in a low-grade activation (fight or flight response) can show up without you even knowing it. IWhy giving back, connecting with others, and creating more joy can help you feel more groundedHow technology can become part of the solution when it is designed with human well-being in mindThis conversation is a gentle reminder that the pace of your life may be asking more of your body than it was ever meant to hold.You don't have to wait until you're exhausted, anxious, or completely overwhelmed to give yourself a pause. Sometimes one small moment of space is enough to help you start hearing what your body and brain have been trying to tell you all along.With love and freedom, LaurieClick here to purchase my “Nervous System Regulation Starter Kit” it's $29.99Click here to purchase my book: Sandwiched: A Memoir of Holding On and Letting GoClick here to watch the Barbie clip referenced in this podcastFree ResourcesClick here to schedule a FREE inquiry call with me.Click here for my FREE “Beginner's Guide to Somatic Healing”Click here for my FREE Core Values ExerciseWebsiteConnect with Dr. Mary Donohue: Victoria on LinkedIn: Dr. Mary DonohueVictoria's email: drmaryedonahue@gmail.com RESOURCES MENTIONED:Digital Wellness Center: Founded by Dr. Mary Donohue, this science-backed platform helps people manage digital stress, take healthier microbreaks, and build more balanced technology habits. Message Received: A book written by Dr. Mary E. Donohue, offering a practical seven-step framework for breaking down communication barriers at work, especially across email, digital tools, video calls, remote teams, and generational communication styles. The Happiness Lab: A podcast hosted by Yale professor Dr. Laurie Santos that shares science-backed insights for improving well-being. How to Win Friends and Influence People:  A classic book by Dale Carnegie that shares practical principles for building stronger relationships, improving communication, and positively influencing others. How to Stop Worrying and Start Living: A book by Dale Carnegie that shares practical lessons and real-life stories for managing worry, finding purpose, and living with more peace. Please leave me feedback. I cannot respond so if you'd like me to respond, please leave your email***********************DISCLAIMER: THE COMMENTARY AND OPINIONS AVAILABLE ON THIS PODCAST ARE FOR INFORMATIONAL AND ENTERTAINMENT PURPOSES ONLY AND NOT FOR THE PURPOSE OF PROVIDING LEGAL, MEDICAL OR PROFESSIONAL ADVICE. YOU SHOULD CONTACT A LICENSED THERAPIST IF YOU ARE EXPERIENCING SUICIDAL THOUGHTS. YOU SHOULD CONTACT AN ATTORNEY IN YOUR STATE TO OBTAIN LEGAL ADVICE. YOU SHOULD CONTACT A LICENSED MEDICAL PROFESSIONAL WITH RESPECT TO ANY MEDICAL ISSUE OR PROBLEM.

What kind of man gets studied at Yale, Brown, and Harvard, builds a 300 person international research consortium, and still has powerful people working to erase his name? Dr. Daniel Ingram is not a guru. He is a retired level one trauma emergency physician. A published neuroscience researcher. The author of a book that has shaped contemplative practice for tens of thousands of readers. The acting organizer of a global research effort spanning Harvard, Yale, Brown, Cambridge, and Oxford. By every credential medicine respects, he is one of their own.So why did a senior figure allegedly commission an academic article engineered to surface at the top of every search of his name, with one stated goal? That nobody would ever believe him again. Because Dr. Ingram crossed a line his profession does not permit. He claimed that awakening is real. That it is measurable. That it is observable in the brain.  We go into what he has seen at the edges of human perception. What he documented in the lab. What he believes medicine is doing to patients every single day by refusing to look.The Emergent Phenomenology Research Consortium

Howie and Harlan are joined by Mark Siegel, director of Yale's internal medicine residency program, to discuss his approach to mentoring young physicians and building a medical community grounded in purpose and compassion. Harlan examines a breakthrough targeted therapy that could reshape the treatment of pancreatic cancer and other hard-to-treat cancers; Howie tracks the Ebola outbreak in the Democratic Republic of the Congo and argues that policy decisions are hampering the global response. Show notes: A Cancer Breakthrough Pancreatic cancer: Symptoms and causes "Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer" "Multi-Selective RAS(ON) Inhibitor Nearly Doubles Survival Time in People With Metastatic Pancreatic Cancer" "KRAS mutation: from undruggable to druggable in cancer" Mark Siegel Mark Siegel: Program Director Notes Mark Siegel on Substack Academic medicine Signaling system Mark Siegel: "What I've Learned in 63 Years" Yale School of Medicine: Residency & Fellowship Programs Mark Siegel: "A Sudden Loss Of Vision"  Health & Veritas Episode 224: Nicholas Christakis: The Science of Human Connection Ebola WHO: Bundibugyo virus disease outbreak, Democratic Republic of the Congo WHO: Ebola, The Democratic Republic of the Congo, 2026   WHO: Alert and Response "'We are catching up'—WHO chief on DR Congo's Ebola fight"  "Uganda Closes Border With Congo as Ebola Fears Rise" "Kenyan Court Deals New Blow to Plans for U.S. Ebola Unit" In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.

Low energy is not always about needing more sleep. In this episode of The Women's Vibrancy Code, Maraya Brown shares why chronic fatigue, burnout, brain fog, hormone imbalance, nervous system dysregulation, and emotional misalignment may be the real reasons you still feel exhausted even after 8 hours of sleep and how to begin restoring your energy, vitality, and connection to yourself again.     The Women's Vibrancy Accelerator Trifecta: Your 90-Day Health Reset Ready to take your health to the next level? The Women's Vibrancy Accelerator Trifecta offers deep, personalized support to help you regain control of your energy, hormones, and well-being. This program includes: Three one-on-one calls with Maraya Dutch Plus Test and full assessment Bi-weekly live Q&A sessions Self-paced health portal covering energy, hormones, libido, and confidence   Podcast listeners get an exclusive discount. Use code PODCAST. Learn more and enroll now: https://marayabrown.com/trifecta/ _______________________ Free Wellness Resources Access free tools like the Menstrual Tracker, Adaptogen Elixir Recipes, Two-Week Soul Cleanse, Food Facial, and more. Download now: https://marayabrown.com/resources/ _______________________ Subscribe to The Women's Vibrancy Code Podcast Listen on Apple Podcasts, YouTube, and Spotify. _______________________ Connect with the Show Find us on Facebook,  Linkedin | Website | Tiktok | Facebook Group _______________________ Apply for a Call with Maraya Brown Start your journey with personalized support. Apply here: https://marayabrown.com/call  _______________________ About Maraya Brown Maraya is a Yale and Functional Medicine-trained Women's Health and Wellness Expert (CNM, MSN). She helps women feel energized, confident, and connected to themselves and their lives. With over 25 years of experience, she specializes in energy, hormones, libido, confidence, and deep transformation. _______________________ Disclaimer The content of this podcast is for informational, educational, and entertainment purposes only and does not constitute medical or professional advice. Listeners should consult with a qualified professional before making any health decisions.   This Podcast Is Produced, Engineered & Edited By: Simplified Impact 

Here is a recap of Day 3 of the 2026 Route Inspection. Our day started in Guthrie Center, we then visited Panora, Yale, Perry (Meeting Town), Ogden, and ended our day in Boone. We biked about 61 miles and experienced a total elevation of about 1,500 feet of climbing. Joining Murph & AP is Bob Libby from Care Ambulance. Be sure to catch up with the JustGoBike Podcast daily reports on each day of the RAGBRAI Inspection Ride! Co-hosts AP and Murph will fill you in on the ups and downs of the route, news and highlights from the RAGBRAI LIII communities, interviews with fellow Route Inspectors, and more! Registration for RAGBRAI LIII: www.ragbrai.com Watch, or listen on our Just Go Bike YouTube channel. https://www.youtube.com/@JustGoBikePodcast Have a topic for a future episode? Message us at justgobikepodcast@gmail.com.

Today I'm joining in conversation with my friend James Bryan Smith to finally share something that's been in the works for over a year now. Jim is the author of The Good and Beautiful book series. A founding member of Richard J. Foster's spiritual renewal ministry, Renovaré, Smith is an ordained United Methodist Church minister and has served in various capacities in local churches. He earned his MDiv at Yale and his DMin at Fuller and is a theology professor at Friends University in Wichita, Kansas, where he also serves as the director of the Apprentice Institute for Christian Spiritual Formation. About a year ago he called me up with an idea for a way to serve writers. That's where our conversation today begins. Even if you aren't a writer, our conversation will, I hope, shed light on how ideas become reality, how sometimes a good idea takes a decade to grow, and the beauty of collaboration, patience, and moving at a human pace. I hope you'll listen in. LINKS + RESOURCES FROM THIS EPISODE: Learn more about the Formation Writers Guild The Good and Beautiful Series by James Bryan Smith Apprentice Institute for Christian Spiritual Formation Renovaré FIND EMILY ELSEWHERE: Leave a review on Apple Podcasts Download The Quiet Collection app Join The Soul Minimalist Substack Order a How to Walk into a Room Download the free discussion guide for How to Walk into a Room by visiting this page and clicking the button "Discussion Guide"

Modern loneliness is often treated as a simple problem: People are simply spending more time alone. But what if that's not the whole story? Over the last several years, Derek has written about workism, the rise of a culture that puts work at the center of our lives, and the "antisocial century," in which technology has made it easier than ever to avoid spending time with other people. The result is a world where many of us trade deep connection for convenience, productivity, and fleeting hits of entertainment. Today, Derek talks with Yale psychology professor and Happiness Lab host Laurie Santos about the science of friendship, connection, and loneliness. What do we misunderstand about being alone? Why are male friendships harder to maintain? And how can we build stronger relationships in a world that seems designed to pull us apart? Subscribe to our YouTube channel here:https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Laurie Santos Producer: Devon Baroldi Additional Production Support: Ben Glicksman Learn more about your ad choices. Visit podcastchoices.com/adchoices

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBIBLIOGRAPHYHidden Rooms, Holy Water, and the DeadWhite, L. Michael. The Social Origins of Christian Architecture, Volume I: Building God's House in the Roman World: Architectural Adaptation Among Pagans, Jews, and Christians. Trinity Press International, 1996. Key use: Essential source for early Christian architectural adaptation, especially the shift from domestic and semi-domestic gathering spaces toward more specialized Christian buildings. White's work is useful for showing that early Christian architecture develops inside a broader Roman social and architectural world, not in isolation.White, L. Michael. The Social Origins of Christian Architecture, Volume II: Texts and Monuments for the Christian Domus Ecclesiae in Its Environment. Trinity Press International, 1997. Key use: Companion volume for the textual and archaeological evidence behind the domus ecclesiae, early meeting spaces, and the built environment of pre-Constantinian Christianity.Yale University Art Gallery. “Christian Building.” Dura-Europos: Excavating Antiquity. Key use: Strong anchor for the Dura-Europos Christian building and its wall paintings. Yale notes that the Christian paintings were uncovered in 1932 and that Clark Hopkins described the murals as preserved from more than three-quarters of a century before Constantine recognized Christianity in 312.Yale News. “House Call: A New Study Rethinks Early Christian Landmark.” 2024. Key use: Useful cautionary source for not oversimplifying Dura-Europos as merely a domestic “house church.” The report highlights recent scholarship reexamining how domestic the Dura Christian building really was and why its architectural classification needs care.Smarthistory. “Dura-Europos.” Key use: Accessible overview of Dura-Europos as a multicultural Roman frontier site, including the adapted Christian building used as a meeting place and baptistery in the first half of the third century.Peppard, Michael. The World's Oldest Church: Bible, Art, and Ritual at Dura-Europos, Syria. Yale University Press, 2016. Key use: Major source for the Dura-Europos Christian building, its baptistery, biblical imagery, ritual use, and the danger of reading the site too simply through later church categories.Snyder, Graydon F. Ante Pacem: Archaeological Evidence of Church Life Before Constantine. Mercer University Press, revised edition, 2003. Key use: Important archaeological source for Christian life before Constantine, especially material evidence for worship, burial, symbols, and everyday Christian practice before public imperial privilege. Mercer University Press identifies the book as focused on archaeological evidence of church life before Constantine.Jensen, Robin M. Baptismal Imagery in Early Christianity: Ritual, Visual, and Theological Dimensions. Baker Academic, 2012. Key use: Core source for baptismal images, ritual meaning, water, initiation, death and rebirth, and the way visual programs frame baptismal practice.Jensen, Robin M. Understanding Early Christian Art. Routledge, 2000. Key use: Early Christian visual culture, catacomb imagery, baptismal scenes, Good Shepherd imagery, Jonah, Daniel, Lazarus, and the visual language of salvation and resurrection.Ferguson, Everett. Baptism in the Early Church: History, Theology, and Liturgy in the First Five Centuries. Eerdmans, 2009. Key use: Major historical and theological source for baptismal practice, initiation, immersion, anointing, catechesis, and the development of baptismal rites.Johnson, Maxwell E. The Rites of Christian Initiation: Their Evolution and Interpretation. Liturgical Press. Key use: Development of initiation rites, catechumenate, baptism, post-baptismal rites, and how Christian initiation becomes structured over time.Spinks, Bryan D. Early and Medieval Rituals and Theologies of Baptism: From the New Testament to the Council of Trent. Ashgate, 2006. Key use: Long-range ritual and theological development of baptism, useful for tracking how early baptismal space later becomes more formalized.Britannica. “Catacomb.” Key use: Baseline definition of catacombs as subterranean cemeteries composed of galleries or passages with recesses for tombs; useful for correcting the popular misconception that catacombs were primarily secret churches rather than burial landscapes.Stevenson, James. The Catacombs: Rediscovered Monuments of Early Christianity. Thames & Hudson, 1978. Key use: Classic overview of Roman catacombs, burial architecture, inscriptions, symbols, and early Christian memory.Rutgers, Leonard V. Subterranean Rome: In Search of the Roots of Christianity in the Catacombs of the Eternal City. Peeters, 2000. Key use: Catacombs as archaeological and social evidence, including burial practice, community identity, and the relationship between Jews, Christians, and Roman funerary culture.Fiocchi Nicolai, Vincenzo, Fabrizio Bisconti, and Danilo Mazzoleni. The Christian Catacombs of Rome: History, Decoration, Inscriptions. Schnell & Steiner, 2002. Key use: Detailed treatment of catacomb history, inscriptions, burial spaces, and visual programs.Brown, Peter. The Cult of the Saints: Its Rise and Function in Latin Christianity. University of Chicago Press, enlarged edition. Key use: Essential source for the holy dead, saint veneration, relics, tombs, pilgrimage, and the way corporeal remains became central to Christian religious life. The University of Chicago Press describes Brown's work as exploring how worship of saints and their corporeal remains became central to religious life in Western Europe.Brown, Peter. The Body and Society: Men, Women, and Sexual Renunciation in Early Christianity. Columbia University Press, 1988. Key use: Christian body theology, asceticism, holiness, discipline, and why the body is so central to late antique Christian imagination.Yasin, Ann Marie. Saints and Church Spaces in the Late Antique Mediterranean: Architecture, Cult, and Community. Cambridge University Press, 2009. Key use: Churches, saints, relics, cult practice, community identity, and how sacred spaces are organized around holy bodies and memory.Grabar, André. Martyrium: Recherches sur le culte des reliques et l'art chrétien antique. Key use: Classic work on martyr shrines, relic cult, and the relationship between architecture, art, and the holy dead.van Gennep, Arnold. The Rites of Passage. Key use: Separation, liminality, and incorporation. Crucial for baptism, catechumenate, thresholds, initiation, and the movement from outsider to insider.Turner, Victor. The Ritual Process: Structure and Anti-Structure. Key use: Liminality, threshold states, ritual transition, and communitas. Useful for baptism, catacomb descent, martyr devotion, and controlled access.Kilde, Jeanne Halgren. Sacred Power, Sacred Space: An Introduction to Christian Architecture and Worship. Oxford University Press, 2008. Key use: Christian buildings as arrangements of power, worship, divine presence, and embodied access. Useful for thresholds, sanctuary divisions, nave, altar, and congregation.Kieckhefer, Richard. Theology in Stone: Church Architecture from Byzantium to Berkeley. Oxford University Press, 2004. Key use: Church architecture as theology made spatial. Useful for altar, pulpit, nave, threshold, symbolic layout, and worship practice.Krautheimer, Richard. Early Christian and Byzantine Architecture. Yale University Press / Pelican History of Art. Key use: Classic architectural history for early Christian and Byzantine buildings, including the shift from pre-Constantinian spaces to basilicas, baptisteries, martyr shrines, and later monumental forms.Mathews, Thomas F. The Clash of Gods: A Reinterpretation of Early Christian Art. Princeton University Press, 1993. Key use: Early Christian imagery, visual conflict, ritual meaning, and the development of Christian art within the Roman world.Elsner, Jaś. Imperial Rome and Christian Triumph: The Art of the Roman Empire AD 100–450. Oxford University Press, 1998. Key use: Roman visual culture, Christian adaptation, imperial imagery, and the shift into Christian public art and architecture.MacMullen, Ramsay. Christianizing the Roman Empire: A.D. 100–400. Yale University Press, 1984. Key use: Social and historical context for Christian expansion before and after Constantine, useful for understanding how Christian space changes as Christianity grows.Mango, Cyril. Byzantine Architecture. Key use: LonAlso want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

This episode is a must-listen for anyone concerned about the direction of our country. The speaker takes a closer look at a Colorado congressional candidate who's been flying under the radar, but his radical views and actions are anything but subtle. From his time as a Yale law student to his current run for office, this candidate has a history of pushing a far-left agenda that's out of touch with the values of his constituents.This episode delves into the candidate's background, revealing a pattern of behavior that's more about ideology than representation. We explore his connections to prominent progressive politicians, his involvement in radical activism, and his voting record on key issues like healthcare and immigration. The speaker also examines the candidate's claims about his moderate stance on certain issues, questioning whether he's truly committed to representing the people of Colorado or just trying to sell himself as a more palatable alternative.One of the most striking aspects of this candidate's record is his history of pushing a far-left agenda, from suing the EPA over slaughterhouse rules to advocating for a tax on meat, dairy, and eggs. His voting record shows a consistent pattern of supporting policies that benefit special interests and ignore the needs of his constituents. The speaker also highlights the candidate's connections to prominent progressive politicians, including Bernie Sanders and Elizabeth Warren, who have praised him by name.If you're concerned about the direction of our country and the kind of politicians we're electing to office, this episode is a must-listen. The speaker takes a closer look at the facts and exposes the candidate's true record, revealing a pattern of behavior that's more about ideology than representation. Tune in to hear the full story and decide for yourself whether this candidate is truly representing the people of Colorado.See omnystudio.com/listener for privacy information.

Julia Regier is a policy and research manager at MIT's Stone Center on Inequality and Shaping the Future of Work, where she focuses on workforce and policy impacts. Her path here was anything but straight, from studying philosophy at Wellesley to an MBA at Yale to translating dense economics research for people who don't speak economics. We talk about what the data shows for workers without college degrees (spoiler: it's not great, and it's been getting worse since 1980), why the self-checkout AI surveillance story is a perfect case study in automation gone wrong, and what it would take to redirect AI development toward something that works for workers, not just around them. We also get into the market failure at the heart of how AI is being built, why a handful of people setting the vision for all of us is a problem, and what policy levers could shift things. Julia also makes the moral case, loud and clear, for a living wage, and we're here for it. Chapters 00:00 - Intro - Felicia and Rachel talk local politics, civic assemblies, and more 20:28 - Welcome Julia! Her Nonlinear Path: Philosophy, Recruiting & Landing at MIT 25:00 - Worker Ownership, Co-ops & Why It's Harder Than It Sounds 29:35 - Job Quality for Workers Without College Degrees: What the Data Shows 37:00 - AI Surveillance, Self-Checkout & the Annoyance Factor 43:45 - Taking the Long View: Policy Impacts & the Case for Investing in Children 49:40 - Who's Setting the Vision for AI (and Why That's a Problem) 54:26 - Pro-Worker AI: Policy Levers That Could Actually Change Course 62:00 - Gender, Diversity & Who's Missing from the Research 65:20 - If You Could Change One Thing + Closing Thoughts Visit us at InclusionGeeks.com to stay up to date on all the ways you can make the workplace work for everyone! Check out Inclusion Geeks Academy and InclusionGeeks.com/podcast for the code to get a free mini course.

Do I, intrinsically matter? Do you? Based on...what? There is almost a saturation of information and ideas on what purpose is and having purpose in your life. But if you dig down, I find purpose to primarily be a pursuit to...matter. Do we matter just because we exist? Many religions say so, but I generally find the religious scrambling to prove they matter in the same ways everyone else is. So does that testify that we have to do something to matter? This is the episode. I sat down with renowned philosopher and intellectual, Rebecca Goldstein. Rebecca is an award-winning philosopher and writer. She is the author of ten books of acclaimed fiction and non-fiction. She holds a Ph.D. in philosophy of science from Princeton University and has taught at Yale, Columbia, NYU, Dartmouth, and Harvard. In 2015, she was awarded the National Humanities Medal by President Obama. In many ways however, from all of Rebecca's philosophical pursuits, the concept of mattering is her culmination of wisdom. Her new book is called, The Mattering Instinct: How Our Deepest Longing Drives Us and Divides Us. In this conversation we dive straight into how we perceive mattering, what we generally do to matter, and what actually results in feelings of mattering. We discuss the cultural and relational conflicts we have around what and who we think matters most. Rebecca then identifies four psychological types based on how people pursue mattering, which in itself begs the question: We generally pursue proving that we matter. Belying we think mattering is earned. I found the conversation very revealing and bringing me to consider my core motives for my life. Sign up for your $1/month trial period at shopify.com/kevin Go to shipstation.com and use code KEVIN to start your free trial. Learn more about your ad choices. Visit megaphone.fm/adchoices

Kimberly explores the surprising science of sun exposure with Rowan Jacobsen, challenging common fears about sunlight and revealing its profound health benefits. Learn how to balance sun safety with the need for natural light to improve health, mood, and longevity.Chapters00:00 Introduction to Sunlight and Health02:52 The Historical Perspective on Sunlight06:00 Understanding Skin Cancer and Sun Exposure08:50 The Benefits of Sunlight Beyond Skin Cancer12:02 Sensible Sun Exposure and Aging14:56 Circadian Rhythms and Sunlight17:56 Alternatives to Natural Sunlight20:58 Vitamin D and Its Importance24:41 The Vitamin D Dilemma29:59 Sunlight and Fertility33:40 In Defense of Sunlight38:53 The Impact of Light on Children43:44 Sunscreen InsightsSponsor: ANIMA MUNDI OFFER: Anima Mundi is giving Feel Good Podcast listeners they're largest discount of the year. It's a great opportunity to treat yourself or a friend to some soothing self-care by going to AnimaMundiHerbals.com and use the code: SOLLUNA20 for 20% off your purchase. USE LINK: AnimaMundiHerbals.com Code: SOLLUNA20 for 20% off your purchase.Rowen Jacobsen Resources: Book: In Defense of Sunlight: The Surprising Science of Sun Exposure (June 16th, 2026) (Simon & Shuster) Website: rowanjacobsen.com Social: @unrealrowanjacobsen Email: rowanjacobsen@gmail.comBio: Rowan Jacobsen writes about science and nature and the less-explored corners of the world for Harper's, Outside, The Atlantic, Scientific American, Smithsonian, The New York Times, The Washington Post, MIT Technology Review, Businessweek, and others, and his work has been anthologized in The Best American Science & Nature Writing and other collections. He has received awards from the James Beard Foundation, the Society of American Travel Writers, and the Overseas Press Club. He is the author of nine books, including A Geography of Oysters, Fruitless Fall, and Truffle Hound, which have been named to Best Book of the Year lists by the Washington Post, Wall Street Journal, Boston Globe, NPR, and Publishers Weekly. He has performed with Pop-Up Magazine, lectured at Harvard and Yale, and appeared on CBS, NBC, and NPR. He has been an Alicia Patterson Foundation Fellow, writing about endangered diversity on the borderlands between India, Myanmar, and China; a Knight Science Journalism Fellow at MIT, focusing on the environmental and evolutionary impact of synthetic biology; and a Nova Media Fellow, researching the science of sun exposure. His new book, In Defense of Sunlight: The Surprising Science of Sun Exposure, will be published by Scribner on the Summer Solstice, 2026.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's guest is Will Goetzmann, Professor of Finance at the Yale School of Management. He is an expert on financial markets and securities, investment strategies, investor behavior and financial history. In today's episode, Professor Goetzmann walks through 5,000 years of financial history, showing how finance shaped trade, cities, corporations, and investing. He covers the first compound interest calculation, the world's oldest corporations and bonds, and historic bubbles from tulips to NFTs. To close, he explains why markets have repeatedly adapted through war, crisis, and uncertainty. (0:00) Starts (1:50) William Goetzmann on origins of money (7:06) The history of corporations (14:43) Yale's historical bond and early financial innovation (17:33) Parallels between historical and modern financial bubbles (25:52) SpaceX IPO and market valuations (27:26) Herd mentality and bubbles (32:47) Global investing, inflation, and currencies (41:13) Finance-related art (46:31) Most memorable investment ----- Sponsor: Ivy Invest - To learn more about Ivy Invest's SEC-registered endowment-style fund, view the prospectus, and learn how to invest, visit ivyinvest.co/fund ----- Follow Meb on X, LinkedIn and YouTube For detailed show notes, click here To learn more about our funds and follow us, subscribe to our mailing list or visit us at cambriainvestments.com ----- Follow The Idea Farm: X | LinkedIn | Instagram | TikTok ----- Interested in sponsoring the show? Email us at Feedback@TheMebFaberShow.com ----- Past guests include Ed Thorp, Richard Thaler, Jeremy Grantham, Joel Greenblatt, Campbell Harvey, Ivy Zelman, Kathryn Kaminski, Jason Calacanis, Whitney Baker, Aswath Damodaran, Howard Marks, Tom Barton, and many more.  ----- Meb's invested in some awesome startups that have passed along discounts to our listeners. Check them out here!  ----- Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Learn more about your ad choices. Visit megaphone.fm/adchoices

Meet my friends, Clay Travis and Buck Sexton! If you love Verdict, the Clay Travis and Buck Sexton Show might also be in your audio wheelhouse. Politics, news analysis, and some pop culture and comedy thrown in too. Here’s a sample episode recapping four takeaways. Give the guys a listen and then follow and subscribe wherever you get your podcasts. Branding vs. Education Clay Travis and Buck Sexton give an in‑depth critique of the American higher education system, with specific attention to grade inflation, standardized testing, and admissions fairness. The hosts highlight Harvard University’s decision to eliminate widespread grade inflation and reintroduce a bell curve grading model, noting that a large majority of students had been receiving A grades. They trace the historical roots of grade inflation back to the Vietnam War era, when professors were reluctant to assign low grades that could result in students being drafted, and argue that the COVID‑19 pandemic accelerated the trend by lowering academic expectations nationwide. The conversation expands into a broader analysis of elite universities such as Harvard, Yale, and Stanford, comparing traditional grading systems with pass‑fail models used in some law schools. While acknowledging arguments that elite students perform at a higher level, the hosts ultimately contend that grade inflation has eroded academic standards and made it harder to distinguish top performers. This leads into a discussion of the rise and fall of test‑optional admissions policies, which surged during 2020 but were later reversed after colleges found that standardized testing remained one of the most reliable ways to evaluate student readiness. Get Smarter Listening to This Ryan Girdusky joins the show to dissect the Democratic National Committee’s “autopsy” of the 2024 election loss, which returned Donald Trump to the presidency. The hosts highlight dramatic long-term political realignment trends, noting how Democrats have lost significant ground since 2009 across the Senate, House, governorships, and state legislatures, with Republicans gaining dominance in key regions. Girdusky argues the DNC report fails to address critical issues—especially Joe Biden’s age and Kamala Harris’s campaign weaknesses—while crediting effective Trump campaign messaging for reshaping voter perceptions. The discussion underscores how Republican gains, particularly in the South, reflect a broader collapse of historic Democratic strongholds and the lingering impact of the Obama era on local politics. MN Fraud Isn't a One-Off Clay and Buck discuss the breaking news of a major Minnesota fraud case, where the mastermind behind the “Feeding Our Future” scheme is sentenced to more than 41 years in prison for orchestrating a $250 million COVID relief fraud, funds originally intended to feed children. Clay and Buck highlight this case as a symbol of broader systemic government waste, fraud, and abuse, arguing that such large-scale theft underscores failures in federal oversight and accountability. The conversation expands into a critique of government spending and fiscal policy, with the hosts asserting that fraud like this is not an isolated incident but part of a larger trend of mismanagement of taxpayer dollars. They argue that calls from Democrats to raise taxes—particularly on high earners—ignore the core issue of inefficient spending, contending that Americans are already overpaying into a system riddled with waste. This naturally leads into a broader economic debate, including criticism of progressive figures such as Zohran Mamdani and commentary on Jeff Bezos’ public remarks about taxation and public spending, which the hosts use to argue that increasing tax revenue does not necessarily lead to better outcomes in public services like education. After the Sports High... Clay chats with Steve Eubanks, sports journalist and author of “Godball” - the first book to seriously examine the modern surge of public Christian faith in American sports. Steve interviewed high-profile Christian athletes including Scottie Scheffler, Riley Gaines, Kirk Cousins, Jonathan Isaac, Dabo Swinney, and others, allowing them to share—in their own words—the role faith plays in their careers and lives. Steve explores the pivotal moment one Supreme Court case made and offers rare insight from athletes and coaches into this growing revival of faith in sports. Make sure you never miss a second of the show by subscribing to the Clay Travis & Buck Sexton show podcast wherever you get your podcasts! ihr.fm/3InlkL8 For the latest updates from Clay and Buck: https://www.clayandbuck.com/ Connect with Clay Travis and Buck Sexton on Social Media: X - https://x.com/clayandbuck FB - https://www.facebook.com/ClayandBuck/ IG - https://www.instagram.com/clayandbuck/ YouTube - https://www.youtube.com/c/clayandbuck Rumble - https://rumble.com/c/ClayandBuck TikTok - https://www.tiktok.com/@clayandbuck YouTube: https://www.youtube.com/@VerdictwithTedCruzSee omnystudio.com/listener for privacy information.