Podcasts about National Cancer Institute

Cancer, autoimmunity, chronic pain — research scientist Ian Mitchell makes the case they're not the genetic life sentences we've been told. Liz and Becca get into carbon 60 and mitochondrial energy, what to do first in an autoimmune flare, the metabolic argument that got him nominated to run the National Cancer Institute, stem cells that cross the blood-brain barrier, and his own spike-protein crash. Opinionated, not medical advice — bring it to your practitioner. Connect with Ian: Instagram See Wizard Sciences products *** CONNECT:

HEALTH NEWS   Ginger Supplementation Reduces Muscle Soreness, Review Finds Artificially sweetened and sugar-sweetened beverage intake and risk of liver cancer Plant-based quinoa burgers reduce post-meal blood sugar spikes Sleep and exercise may curb heart risk from mutant white blood cells Pregnant women may reduce key health risk through less sitting, more light exercise     Ginger Supplementation Reduces Muscle Soreness, Review Finds Old Dominion University, June 4 2026 (Natural News)     A review published in Nutrition Reviews found that consuming 2 grams of ginger daily for 11 consecutive days before exercise reduced delayed-onset muscle soreness (DOMS) by 23% to 25%.   The review examined multiple placebo-controlled studies and found that single doses taken just before exercise did not produce significant pain reduction, but consistent daily intake over the 11-day period yielded measurable results.   DOMS typically occurs 24 to 72 hours after exercise and is a common reason individuals skip subsequent workouts. In two placebo-controlled studies reviewed, participants consumed 2 grams of either raw or heat-treated ginger daily for 11 days before performing eccentric exercise, which lengthens muscles under tension. The effective dose identified in the review was 2 grams per day, roughly equivalent to one teaspoon of fresh grated ginger.   Artificially sweetened and sugar-sweetened beverage intake and risk of liver cancer Yale University, National Cancer Institute, Boston University, June 10 2026 (Eurekalert) Are artificially sweetened beverage (ASB) and sugar-sweetened beverage (SSB) intakes associated with risk of liver cancer overall and by subtype (hepatocellular carcinoma [HCC] and intrahepatic cholangiocarcinoma [ICC])? In this pooled analysis of 11 prospective cohort studies comprising 1,518,411 adults, SSB intake per 1-beverage/day increment was associated with increased risk of HCC and ICC, whereas ASB intake was not associated with liver cancer overall or by subtype. There was no evidence of effect modification by diabetes status.     Plant-based quinoa burgers reduce post-meal blood sugar spikes Federal University of Golas (Brazil), June 10 2026 (News-Medical) A study published in ACS Nutrition Science suggests that a plant-based burger made from baru pulp and red quinoa could reduce post-meal blood glucose responses in healthy adults. Red quinoa (Chenopodium quinoa Willd.) is a pseudocereal that is rich in protein, fiber, and micronutrients. It provide spolyphenols that have been shown to slow gastric emptying and overall digestion, and may reduce enzymatic degradation of carbohydrates in the gut. This would influence the rate at which glucose is absorbed into the bloodstream after a meal, altering the GI. The authors of this pilot study examined GI in a small sample of eight volunteers after consuming two plant-based burgers: one made with baru pulp and red quinoa, and the other with red quinoa alone.  All three foods produced their highest blood glucose levels 30 minutes after consumption. The glucose reference food generated the largest peak at 174 mg/dL, while the baru pulp–red quinoa and red quinoa burgers reached substantially lower peaks of 118 mg/dL and 120 mg/dL, respectively. By 120 minutes, blood glucose levels had declined in all groups. Compared with the glucose reference, both plant-based burgers caused only modest increases in blood glucose relative to fasting levels: 15.5% for the red quinoa burger and 18% for the baru pulp–red quinoa burger.   Sleep and exercise may curb heart risk from mutant white blood cells Mount Sinai Hospital, June 10. 2026 (Medical Xpress) Healthy sleep and regular exercise can work to counteract genetic mutations in white blood cells that are associated with cardiovascular disease and are most common among older people, Mount Sinai researchers have found. In a study published in Nature, the team reported for the first time that sufficient sleep and exercise can help reduce the cancer-like cell expansion and atherosclerotic risk linked to mutations that spontaneously occur in white blood cells. These mutations accumulate over our lifetimes and occur most often in hematopoietic stem cells, which are the cells in bone marrow that make blood cells, including macrophages and monocytes, immune cells that help defend the body. When these cells develop mutations, they start to proliferate, multiplying faster than they should, and become more inflammatory, irritating or damaging tissues in the body. This condition, known as clonal hematopoiesis (CH), is detectable in a quarter of people over age 70 and half of people over 80, though it is infrequent in young, healthy people. Healthy sleep and exercise was found to selectively influence immune cells with clonal hematopoiesis mutations, repressing their proliferative programming and expansion, as well as their ability to promote the formation of harmful plaque in the arteries of the heart. The findings reveal that CH mutant cells are malleable and selectively responsive to lifestyle behavior in a way that can mitigate atherosclerotic risk. Mount Sinai researchers discovered that moderate-to-vigorous physical activity was associated with a reduced incidence of gene-specific CH and fewer mutant cells in the blood. Sufficient sleep and exercise "turned off" the detrimental effects of rogue Jak2 and Tet2 mutant CH hematopoietic stem cells in the bone marrow, decreasing their ability to proliferate and grow, a precancerous process known as "clonal expansion.   Pregnant women may reduce key health risk through less sitting, more light exercise University of Iowa, June 10 2026 (Eurekalert)   Women who engage in light physical activity and lessen their sedentary time may significantly reduce the risk of key health problems during pregnancy, according to a new University of Iowa-led study. Researchers examined the daily behaviors of 470 pregnant women across all stages of pregnancy. Each participant wore a monitor that measured physical activity in 24-hour cycles and another monitor that recorded the time they spent asleep. Based on observational data collected from the study's participants, the researchers propose a “Goldilocks Day”-like guide for pregnant women that could reduce by nearly 30% the risk of developing hypertensive disorders of pregnancy (HDP), commonly occurring complications of pregnancy that include chronic hypertension, gestational hypertension, and preeclampsia. Those recommendations are: • Reduce sedentary time to fewer than eight hours each day. • Engage in light physical activity for at least seven hours each day. • Engage in approximately 22 minutes of moderate to vigorous physical activity, such as a brisk walk, each day. • Get nearly nine hours of sleep each night.

Today on The Amber May Show, we are putting children at the center of the conversation. Parents across Arizona are fighting to protect school choice through the ESA program. For many families, ESA means freedom. It gives parents the ability to choose the education that works best for their child, whether that is private school, homeschool, tutoring, therapy, curriculum, or online learning. At the same time, the public school system keeps asking for more money while too many children are falling behind. College students are reportedly losing the ability to read long books. San Francisco schools spent hundreds of thousands of dollars on ethnic studies consultants while student test scores stayed low. Teachers unions are being accused of pushing left-wing political goals through pension pressure, activist curriculum, and classroom influence that can begin as early as kindergarten. We will also look at Oregon, where a grant program is under fire for allegedly using race-based funding rules that leave some schools out because of student demographics. But this show is not only about what is going wrong. We will also talk about what happens when leaders put children first. Melania Trump is launching first-of-its-kind accounts to help foster youth build asset ownership. A new law is being called the largest investment yet to fight child trafficking, with funding for 200 new investigators to help identify exploited children. This is a kid-heavy show, and the question is simple: Are our institutions protecting children, or are they using children to protect the institution? We will talk school choice, parental rights, reading failure, union power, foster youth, and the fight to rescue children from trafficking. https://yournews.com/2026/06/11/7046601/arizona-esa-program-gives-parents-choice-while-saving-the-state/ Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, we are putting children at the center of the conversation. Parents across Arizona are fighting to protect school choice through the ESA program. For many families, ESA means freedom. It gives parents the ability to choose the education that works best for their child, whether that is private school, homeschool, tutoring, therapy, curriculum, or online learning. At the same time, the public school system keeps asking for more money while too many children are falling behind. College students are reportedly losing the ability to read long books. San Francisco schools spent hundreds of thousands of dollars on ethnic studies consultants while student test scores stayed low. Teachers unions are being accused of pushing left-wing political goals through pension pressure, activist curriculum, and classroom influence that can begin as early as kindergarten. We will also look at Oregon, where a grant program is under fire for allegedly using race-based funding rules that leave some schools out because of student demographics. But this show is not only about what is going wrong. We will also talk about what happens when leaders put children first. Melania Trump is launching first-of-its-kind accounts to help foster youth build asset ownership. A new law is being called the largest investment yet to fight child trafficking, with funding for 200 new investigators to help identify exploited children. This is a kid-heavy show, and the question is simple: Are our institutions protecting children, or are they using children to protect the institution? We will talk school choice, parental rights, reading failure, union power, foster youth, and the fight to rescue children from trafficking. https://yournews.com/2026/06/11/7046601/arizona-esa-program-gives-parents-choice-while-saving-the-state/ Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Tracing a trajectory from her medical education in China through a masters degree and PhD in Japan and a fellowship at the National Cancer Institute, Lifang Hou, MD, PhD, has cultivated an international career which now includes spearheading global cancer prevention initiatives that span from Africa to South America. In this episode, she discusses her career journey and how her work in genetics, epigenetics, and early cancer detection is helping bring affordable screening and prevention strategies to underserved communities around the world.

Today on The Amber May Show, Amber is joined by Sam Anthony from YourNews.com and Dan Nunn, host of The Nunn Report, for a packed conversation on election integrity, media credibility, and America's growing trust crisis. The Los Angeles mayoral race is raising serious questions after Spencer Pratt's early lead slipped away and Nithya Raman surged into the runoff with Karen Bass. We'll break down the numbers, the late-counted ballots, the reported 43,000 vote swing, and why the math deserves public scrutiny. My statistical analysis from yesterday showed that if any batch of 24,000 ballots truly went 100 percent to one candidate, that would be nearly impossible under normal voting patterns. Even under a strong 60 to 40 candidate advantage, the odds would be roughly 1 in 10 to the 5,300th power. That does not prove fraud by itself, but it does scream for transparency. We'll also look at fresh voter roll concerns, including a California voter record reportedly listing a woman as 126 years old with 51 ballots cast, and a GOP review that found hundreds of noncitizens on New Jersey voter rolls. Then we turn overseas, where Iran claims it is done bombing Israel while also threatening American oil facilities. What does that mean for U.S. security, energy prices, and Trump's foreign policy posture? Plus, Trump walks out on NBC, a new poll says 55 percent of Democrats would rather live outside the United States, and The Daily Wire reports on how journalism schools are teaching bias to future reporters. It all points to one question: how does a country survive when voters do not trust the count, citizens do not trust the press, and half the political class seems more comfortable attacking America than defending it? Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, Amber is joined by Sam Anthony from YourNews.com and Dan Nunn, host of The Nunn Report, for a packed conversation on election integrity, media credibility, and America's growing trust crisis. The Los Angeles mayoral race is raising serious questions after Spencer Pratt's early lead slipped away and Nithya Raman surged into the runoff with Karen Bass. We'll break down the numbers, the late-counted ballots, the reported 43,000 vote swing, and why the math deserves public scrutiny. My statistical analysis from yesterday showed that if any batch of 24,000 ballots truly went 100 percent to one candidate, that would be nearly impossible under normal voting patterns. Even under a strong 60 to 40 candidate advantage, the odds would be roughly 1 in 10 to the 5,300th power. That does not prove fraud by itself, but it does scream for transparency. We'll also look at fresh voter roll concerns, including a California voter record reportedly listing a woman as 126 years old with 51 ballots cast, and a GOP review that found hundreds of noncitizens on New Jersey voter rolls. Then we turn overseas, where Iran claims it is done bombing Israel while also threatening American oil facilities. What does that mean for U.S. security, energy prices, and Trump's foreign policy posture? Plus, Trump walks out on NBC, a new poll says 55 percent of Democrats would rather live outside the United States, and The Daily Wire reports on how journalism schools are teaching bias to future reporters. It all points to one question: how does a country survive when voters do not trust the count, citizens do not trust the press, and half the political class seems more comfortable attacking America than defending it? Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Find Where we air our show here: https://www.ambermayshow.com/

Tonight is all about Precious Peter and his report of AEW's latest episode of Dynamite. Peter has graciously volunteered to watch AEW Dynamite for the entire month of June. That's four weeks of Peter watching Dynamite. On this episode, we get report from week 1. How did it go? Has Peter started regretting his choices in life? Today we find out.......Did you know that only 4% of the budget of the National Cancer Institute is spent on children's cancer research? 96% of the NCI budget is spent on adult cancer research. That's quite the difference. Our kids deserve more. All kids deserve a fighting chance. 4% doesn't give kids much of a fighting chance. It's time to move that needle! It's kids got #morethan4

Today on The Amber May Show, we start with a surprising piece of American history as Dr. Seuss' famous La Jolla home finds new owners. Then we shift into the stories that hit the heart of the country. A Minneapolis church service was stormed by anti-ICE protesters, yet local prosecutors declined to file state charges, raising serious questions about religious liberty, public safety, and equal justice. Meanwhile, the economy gets a rare bright spot as the latest jobs report beats expectations, even as families continue to feel the weight of inflation. In Washington, the Senate passes a major immigration enforcement package with billions headed toward ICE, CBP, and DHS. We will also break down the failed SAVE Act vote, the fight over election security, Xavier Becerra advancing in California's governor race as mail-in ballots continue to be counted, and the latest results out of the Los Angeles mayoral race. Faith, borders, ballots, and the economy are all colliding. The question is simple: are America's leaders protecting the people, or protecting the system? https://yournews.com/2026/06/02/7025361/arizona-parents-can-beat-the-heat-with-these-budget-friendly-summer/ https://yournews.com/2026/06/05/7032611/spider-noir-brings-superhero-storytelling-back-to-the-family-room/ Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, we start with a surprising piece of American history as Dr. Seuss' famous La Jolla home finds new owners. Then we shift into the stories that hit the heart of the country. A Minneapolis church service was stormed by anti-ICE protesters, yet local prosecutors declined to file state charges, raising serious questions about religious liberty, public safety, and equal justice. Meanwhile, the economy gets a rare bright spot as the latest jobs report beats expectations, even as families continue to feel the weight of inflation. In Washington, the Senate passes a major immigration enforcement package with billions headed toward ICE, CBP, and DHS. We will also break down the failed SAVE Act vote, the fight over election security, Xavier Becerra advancing in California's governor race as mail-in ballots continue to be counted, and the latest results out of the Los Angeles mayoral race. Faith, borders, ballots, and the economy are all colliding. The question is simple: are America's leaders protecting the people, or protecting the system? https://yournews.com/2026/06/02/7025361/arizona-parents-can-beat-the-heat-with-these-budget-friendly-summer/ https://yournews.com/2026/06/05/7032611/spider-noir-brings-superhero-storytelling-back-to-the-family-room/ Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, Amber breaks down a packed news cycle where politics, justice, media, and NASCAR all collide. President Trump is moving to make Todd Blanche the permanent Attorney General, while questions around election integrity heat up from Colorado to California. Trump is now calling for a probe into California's slow vote counting, and the Tina Peters case is back in the spotlight after a DOJ complaint raised new concerns about how Colorado handled one of the most controversial election cases in the country. Then, Amber turns to the media shakeup at CBS after Scott Pelley's contract was terminated, raising fresh questions about legacy media, newsroom power struggles, and who really controls the narrative. Plus, Sarah Talker, NASCAR reporter for YourNews.com, joins the show to talk racing, Kyle Busch, Katherine Legge, and why NASCAR continues to capture the heart of America. From the courtroom to the ballot box to the racetrack, this episode asks one question: who is really in control, the people, the press, or the political machine? Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, Amber breaks down the political shockwaves out of California. Spencer Pratt is projected to advance to a runoff against Los Angeles Mayor Karen Bass, and the media reaction is already raising eyebrows. After MSNBC appeared to cut away during a live segment with Pratt supporters criticizing L.A. leadership, many are asking what corporate media does not want voters to hear. Amber digs into California's slow vote-counting, absentee ballot concerns, voter roll questions, NGO involvement, and the growing distrust Americans feel toward the election system. Can voters still trust the process? Or are citizen candidates and fed-up voters exposing something much bigger? Jaelen Moore, host of Jersey Talk, joins the show. We learn more from Jaelen the inspiration behind starting his show. Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Hollywood is having a very bad week. Nate Bargatze's new film The Breadwinner is getting hammered by critics and struggling at the box office. Disney's Mandalorian is facing a brutal second-week crash. Rihanna's lingerie brand is using Elon Musk's child in a Pride-themed campaign. Jennifer Lopez's child is back in the headlines after coming out as Oskar. The entertainment industry keeps asking why Americans are tuning out. Maybe the answer is simple. Families are tired of being lectured, mocked, and marketed to. But the bigger story is not just Hollywood. It is the election system. Mail-in ballots in Los Angeles County are reportedly being found burned. A voting center was vandalized. The Supreme Court is weighing election cases that could impact redistricting, mail ballots, and campaign cash before the midterms. Meanwhile, Spencer Pratt's outsider campaign is rattling the political class, and the media reaction looks like a brand-new disease: Pratt Derangement Syndrome. Then we turn to Steve Hilton's explosive accusation against Xavier Becerra, claiming migrant children were pushed into the arms of traffickers under failed leadership. Culture. Courts. Ballots. Borders. Today we ask the question the media avoids: How much chaos are Americans supposed to accept before they demand a clean house? Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Hollywood is having a very bad week. Nate Bargatze's new film The Breadwinner is getting hammered by critics and struggling at the box office. Disney's Mandalorian is facing a brutal second-week crash. Rihanna's lingerie brand is using Elon Musk's child in a Pride-themed campaign. Jennifer Lopez's child is back in the headlines after coming out as Oskar. The entertainment industry keeps asking why Americans are tuning out. Maybe the answer is simple. Families are tired of being lectured, mocked, and marketed to. But the bigger story is not just Hollywood. It is the election system. Mail-in ballots in Los Angeles County are reportedly being found burned. A voting center was vandalized. The Supreme Court is weighing election cases that could impact redistricting, mail ballots, and campaign cash before the midterms. Meanwhile, Spencer Pratt's outsider campaign is rattling the political class, and the media reaction looks like a brand-new disease: Pratt Derangement Syndrome. Then we turn to Steve Hilton's explosive accusation against Xavier Becerra, claiming migrant children were pushed into the arms of traffickers under failed leadership. Culture. Courts. Ballots. Borders. Today we ask the question the media avoids: How much chaos are Americans supposed to accept before they demand a clean house? Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Photo by National Cancer Institute on Unsplash In 2018, NY State passed a law requiring that nurses who graduated with a diploma or associate degree in nursing get a baccalaureate degree within 10 years of becoming licensed in the state if they want to continue to practice as a registered nurse. The NYS Education Department recently issued regulations to implement this law and the regulations were approved by the Board of Regents. HealthCetera host Diana Mason, PhD, RN, talked about this law and the regulations with Ann Harrington, MPA, RN, the Executive Director of the New York Organization of Nurse Leaders, including why the public should care about the issue. This interview first aired on HealthCetera in the Catskills on WIOX Radio on May 13, 2026. The post Nursing Education New Regulation Law appeared first on HealthCetera.

Today on The Amber May Show, Amber breaks down Jill Biden's shocking admission about Joe Biden's 2024 debate, the media's role in covering for his decline, and the growing crisis of trust in corporate news. She also covers election integrity, California's fight over ballot investigations, and the collapse of leadership in Los Angeles under Karen Bass. From Biden to ballots to Bass, this episode asks one question: How long have they been lying to the American people? Louder with Crowder Show on Cuba with Cubans https://rumble.com/v7agari-real-cubans-explain-how-communists-are-destroying-their-home-and-the-americ.html Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, Dr Michael Schwartz joins the show, we are looking at a major shift in America's fight for security, sovereignty, and justice. President Trump gave outgoing DNI Tulsi Gabbard a powerful sendoff at today's cabinet meeting, praising her for dramatically reforming the Office of the Director of National Intelligence, cutting staff by 40%, helping stop terrorists and cartel members from entering the country, and exposing what he called mountains of evidence tied to the Russia hoax. But that is only the beginning. The Trump administration's war on the cartels is expanding. Guatemala has reportedly given the green light for U.S. joint strikes against cartel operations inside its borders. At the same time, Mexico's government is going after a border-state governor for working with the United States against cartel violence. We will also talk about the DOJ reportedly launching a criminal investigation into Trump accuser E. Jean Carroll, Trump's potential deal rattling Iranian hardliners, and new concerns over military surveillance and tracking technology. Plus, the battle over illegal immigration is heating up across the country. From Fairfax County, Virginia, where reports suggest a massive illegal immigrant population, to anti-ICE protesters blocking workers and clashing with agents, the question is simple: Who is standing with the American people, and who is protecting the chaos? Today's show is about strength, accountability, and a president moving fast to restore order at home and abroad. Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, we break down the stories exposing the growing battle between government control and everyday American freedom. This week's primary elections revealed where voters are drawing the line. New York's housing fight shows what happens when politicians target private landlords and call it compassion. DHS is warning sanctuary cities that defying federal immigration law may come with real consequences. Oregon voters may face a ballot initiative that could threaten hunting and fishing traditions. And Pam Bondi's private thyroid cancer battle reminds us that public figures often carry silent fights behind the headlines. Then Arizona State Representative Pamela Carter joins the program to talk about the work happening at the state legislature, why local leadership matters, and how Arizona can defend faith, family, freedom, and common sense. https://pamelacarter.com/ Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, we break down the stories exposing the growing battle between government control and everyday American freedom. This week's primary elections revealed where voters are drawing the line. New York's housing fight shows what happens when politicians target private landlords and call it compassion. DHS is warning sanctuary cities that defying federal immigration law may come with real consequences. Oregon voters may face a ballot initiative that could threaten hunting and fishing traditions. And Pam Bondi's private thyroid cancer battle reminds us that public figures often carry silent fights behind the headlines. Then Arizona State Representative Pamela Carter joins the program to talk about the work happening at the state legislature, why local leadership matters, and how Arizona can defend faith, family, freedom, and common sense. https://pamelacarter.com/ Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://marketplace.drstellamd.com/amber-may Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

We've been talking a lot about healthspan and longevity in our recent episodes, but how do we get there? What changes would it take in the way we practice medicine to move towards a system that helps maintain wellness instead of a system that diagnoses and manages disease? This is the fundamental challenge that our guest today and her company, Radence, are tackling. Dr. Julie Chen is the Chief Medical Officer at Radence. An integrative internal medicine physician, she and her colleagues at Radence are working to develop a data-backed model of healthcare that identifies the precursors to problems, allowing for proactive intervention and, in many cases, prevention.  As Dr. Chen says, it will take awhile to amass the data needed to show that spending these resources when a person is well ultimately results in greater health, lower spend, and better longevity, but we have to start somewhere. Dr. Chen is not just a practicing physician, but an accomplished researcher as well. Her research, at the FDA, NIH, National Cancer Institute, USC, and Mount Sinai, has shaped scientific advancement in precision medicine. As a fellowship-trained integrative internal medicine physician, she developed numerous corporate wellness programs in Silicon Valley focusing on whole-systems approach to healthcare and previously served as Chief Medical Officer at companies such as Human Longevity and Vitagene.

Episode Summary: In this episode, I look at diet soda, artificial sweeteners, and the real-world question that matters most: compared with what, at what dose, for whom, and at what tradeoff?Diet Coke, Twinkies, and the Questions That MatterI start with a memory from medical training: a cardiology professor walking around with a Diet Coke in one hand and a Twinkie in his pocket. Was he making a smart tradeoff, or fooling himself? That image captures the artificial sweetener debate well. A diet soda may be a useful substitute if it replaces a sugary drink, but it becomes less compelling if it simply gives us permission to eat more ultra-processed foods.The cleanest case for artificial sweeteners is substitution. In the CHOICE trial, adults who replaced caloric beverages with water or diet drinks lost a modest amount of weight over six months, suggesting that noncaloric beverages can help when they replace sugar-sweetened drinks.  The SWITCH trial similarly found that people assigned to non-nutritive sweetened beverages did at least as well as those assigned to water after a 52-week weight management program. I also explore the common fears around artificial sweeteners. The cancer concern has roots in older animal studies involving very high doses, but the National Cancer Institute notes that the saccharin bladder cancer mechanism seen in rats does not apply to humans, and saccharin was removed from the U.S. carcinogen list in 2000.  A large French observational study, NutriNet-Santé, did find a small association between artificial sweetener intake and cancer risk, especially aspartame and acesulfame-K, but observational studies can't prove causation and are vulnerable to residual confounding. On weight gain and glucose metabolism, the evidence is less alarming than the headlines. Randomized trials do not support the idea that diet soda inevitably causes weight gain. And in the SODAS trial, replacing artificially sweetened beverages with water in adults with type 2 diabetes did not improve glycemic measures, which weakens the claim that diet drinks secretly worsen blood sugar control. The microbiome question is interesting but not settled. A well-known 2014 study suggested artificial sweeteners could alter the gut microbiome and glucose tolerance, but much of that evidence came from mice and a very small human experiment.  More recently, the SWEET study found that sweeteners and sweetness enhancers, when used within a healthy diet, supported weight-loss maintenance and were linked with beneficial gut microbiome shifts in adults with overweight or obesity. The real issue may not be whether Diet Coke is “good” or “bad.” Water wins the purity contest. But food and drink also provide pleasure, ritual, and sustainability. If a diet soda helps someone avoid sugar and enjoy lunch, that may be a reasonable bargain. But if it becomes a permission slip for a daily Twinkie, we should pay attention. Ultra-processed foods matter because in a controlled feeding study, people ate about 500 more calories per day when eating an ultra-processed diet. TakeawaysAsk the better question: not “Is diet soda good or bad?” but “Compared with what, at what dose, for whom, and at what tradeoff?”Artificial sweeteners appear most useful when they replace sugar-sweetened drinks, and less useful when they replace water.Diet soda may be a reasonable pleasure for many people, but it is worth noticing whether it helps reduce sugar—or simply makes the Twinkie in your pocket easier to justify.Send us Fan Mail

Today on The Amber May Show, we start with the media outrage over President Trump acknowledging America's Christian founding as the nation approaches its 250th birthday. On May 17, 1776, the Second Continental Congress called Americans to a day of humility. That history matters. Before America declared independence, our founders understood that freedom needed faith, courage, and moral responsibility. We also talk about Tim Allen's powerful reaction to reading the Old Testament and how the Book of Job left him humbled by God's power and wisdom. Then we turn to the headlines showing what happens when a culture walks away from accountability. From the Austin crime spree, to the teen brawl inside a DC Chipotle, to the deadly Oakland crowd crash, America is facing a deeper crisis than politics. Denzel Washington said it plainly, don't just blame the system. It starts at home. This episode is about faith, family, humility, and the moral foundation America must recover if we want our nation to survive. https://www.heartfirstmedia.com/ Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, President Trump sends a message of strength in Beijing, Jamie Raskin's questioning of a teenage witness backfires on Capitol Hill, and Washington is scrambling over reports involving Tulsi Gabbard, JFK files, and MK-Ultra documents. We also cover new Senate campaign ads accusing Democrats of being soft on crime and Vice President J.D. Vance's push to force states to prove they are prosecuting Medicaid fraud. From China to Congress to taxpayer-funded fraud, today's show is all about accountability. America is done rewarding weakness, excuses, and corruption. Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Send us Fan MailWhat if the future of medicine isn't about treating disease…but detecting it 20 years before symptoms ever appear? Dr. Julie Chen, MD is helping lead one of the newest precision-health companies trying to build that future.Dr. Julie Chen, MD is a physician operating at one of the most interesting intersections in modern medicine: rigorous clinical research, precision longevity medicine, integrative care, and the rapidly evolving world of AI-driven health optimization.Dr. Chen graduated Summa Cum Laude and Phi Beta Kappa from the University of Rochester before earning her M.D. with Distinction in Research and Alpha Omega Alpha honors from the university's School of Medicine. She went on to complete her internal medicine residency and later trained in integrative medicine under Andrew Weil at the University of Arizona Center for Integrative Medicine.Over the course of her career, Dr. Chen has conducted research and published work through institutions including the U.S. Food and Drug Administration, National Institutes of Health, National Cancer Institute, Mount Sinai School of Medicine, and University of Southern California.Dr. Chen has also become a prominent operational leader in the longevity industry, serving in executive medical roles at companies including Human Longevity, Inc., Vitagene, and now as Chief Medical Officer of Radence ( https://radence.com/ ) and Sidestep Health AI. She additionally serves as a Leadership Circle Advisor for the Buck Institute for Research on Aging.What makes Dr. Chen particularly compelling is that she has seen the longevity ecosystem from nearly every angle: academic medicine, FDA-level research, integrative clinical care, Silicon Valley health-tech, and AI-enabled prevention.In today's conversation, we'll explore where the science around longevity is genuinely promising, where the hype may be outrunning the evidence, how precision medicine is shifting toward early disease interception, and what responsible longevity medicine should actually look like in an era increasingly driven by consumer demand and social-media-driven health trends.#Longevity #Peptides #PrecisionMedicine #Healthspan #DrJulieChen #PreventiveMedicine #Biohacking #Aging #DiseaseInterception #GLP1 #LongevityMedicine #AIHealthcare #IntegrativeMedicine #HealthOptimization #HumanLongevity #FutureOfMedicine #MetabolicHealth #PreventiveHealth #Biotech #CraigVenter #Wearables #Biomarkers #Genomics #RadenceSupport the show

Today on The Amber May Show, we are connecting the dots between crime, political protection,  and the larger threats facing America. The soft-on-crime policies continue to put communities at risk, with Democrats struggling to explain why illegal alien murderers keep receiving protection while victims' families are left behind. We also break down Abigail Spanberger's sweeping gun crackdown and why it is already running into legal trouble. Once again, law-abiding Americans are being targeted while criminals ignore the law. Plus, Amber is joined by terrorism expert Dr. Rachel Ehrenfeld, author of Funding Evil and The Soros Agenda. Dr. Ehrenfeld brings her expertise on terrorism financing, money laundering, economic warfare, disinformation, lawfare, corruption, narco-terrorism, and global criminal networks. https://acdemocracy.org/ Book Found Here  https://www.amazon.com/Funding-Evil-Rachel-Ehrenfeld/dp/1566251966 Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Dr. Stella Immanuel joins The Amber May Show to discuss the Hanta Virus, what Americans need to know, and why clear health information matters in a time of fear and confusion. Before the interview, Amber takes on the growing influence of socialist and Marxist ideology in America. Using powerful street-level reporting from Nick Shirley, Amber looks at life under communism, where regime leaders get rich, food disappears, speech is silenced, and equality becomes a broken promise. Amber also breaks down why the rise of openly socialist candidates and movements should concern every American who believes in faith, family, freedom, and the constitutional republic. Plus, she discusses The Daily Wire's piece on women quietly admitting the pain caused by rejecting marriage, motherhood, and family. This episode connects the dots between ideology, culture, public health, and the future of America. Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

The California governor 2026 race is the most crowded gubernatorial primary in state history, and most of the candidates getting the airtime are the ones writing the biggest checks. On this episode of Purple Political Breakdown, host Radell Lewis sits down with Reza Safarnejad, an independent (No Party Preference) candidate for governor of California whose ballot designation is Small Business Owner and whose path into politics started the day the Palisades fire burned his entire neighborhood to ashes. Reza is not a career politician, but he is also not new to how government works. He is an immigrant, a working family man, and a University of Maryland graduate who spent twenty years in leadership roles on large scale federal, state, and local government programs before running for office. From 2006 to 2014 he worked at the National Institutes of Health on national level programs, including the National Cancer Institute's cancer.gov platform that helps doctors and patients find the best treatment options, and large scale virus and genomic research collaboration systems. Since 2014 he has worked in criminal forensics with crime labs and crime scene units across the country (including with the Ohio State Crime Labs), building unbiased, transparent platforms that serve victims and the wrongly accused. He is also the author of the book Veiled Souls and has written and spoken widely on civic issues. After the Palisades fire, Reza spent a year trying to work through California's local and state politicians and help new candidates, and what he found was systemic corruption baked into the party system itself. That is what pushed him from advocate to candidate. In this conversation we cover: the affordability squeeze on working California families, the homelessness factory that no amount of spending seems to fix, the billionaire tax loopholes that quietly hand sixty five percent Airbnb write-offs to the wealthy while regular Californians pay the bill, and the monopolies (Uber, Kroger and Albertsons, PG&E, Blue Cross, DoorDash, the pharma bros pushing ketamine and fentanyl) that he says are draining the state. We get into the Gavin Newsom critique without it becoming a Newsom episode, push back on the framing of the so-called billionaires' tax that excludes real estate moguls and Wall Street, dig into the Palisades fire accountability question, and talk through what California can actually do to push back when a Trump administration starts pulling federal funding and sending in the National Guard. This is a long-form, fact-checking, solutions-focused conversation with one of the lower-name candidates on the June 2 primary ballot. Whether Reza Safarnejad ends up in your top two or not, the conversation maps the issues every California voter should be testing every gubernatorial candidate against: affordability, monopoly power, homelessness, drug enforcement, tax fairness, and what it actually takes to be a governor for the people instead of the donors. Topics covered: California governor 2026 primary, independent candidate California, Palisades fire accountability, California affordability crisis, breaking up monopolies, California wealth tax, billionaire tax loopholes, Airbnb tax write-offs, California homelessness crisis, drug enforcement and marijuana legalization, federal funding fights, Newsom legacy, June 2 primary preview. Visit purplepoliticalbreakdown.com for episode notes, position statements, and the Research on a Dime archive. Subscribe, rate five stars, and share with a friend who's tired of toxic politics and ready for political solutions without political bias.Standard Resource Links & RecommendationsThe following organizations and platforms represent valuable resources for balanced political discourse and democratic participation: PODCAST NETWORKCheck Out the Podcast Website: www.purplepoliticalbreakdown.comALIVE Podcast Network - Check out the ALIVE Network where you can catch a lot of great podcasts like my own, led by amazing Black voices. Link: https://alivepodcastnetwork.com/ CONVERSATION PLATFORMSHeadOn - A platform for contentious yet productive conversations. It's a place for hosted and unguided conversations where you can grow a following and enhance your conversations with AI features. Link: https://app.headon.ai/Living Room Conversations - Building bridges through meaningful dialogue across political divides. Link: https://livingroomconversations.org/ UNITY MOVEMENTSUs United - A movement for unity that challenges Americans to step out of their bubbles and connect across differences. Take the Unity Pledge, join monthly "30 For US" conversation calls, wear purple (the color of unity), and participate in National Unity Day every second Saturday in December. Their programs include the Sheriff Unity Network and Unity Seats at sports events, proving that shared values are stronger than our differences. Link: https://www.us-united.org/ BALANCED NEWS & INFORMATIONOtherWeb - An AI-based platform that filters news without paywalls, clickbait, or junk, helping you access diverse, unbiased content. Link: https://otherweb.com/ VOTING REFORM & DEMOCRACYEqual Vote Coalition & STAR Voting - Advocating for voting methods that ensure every vote counts equally, eliminating wasted votes and strategic voting. Link: https://www.equal.vote/starFuture is Now Coalition (FiNC) - A grassroots movement working to restore democracy through transparency, accountability, and innovative technology while empowering citizens and transforming American political discourse. Link: https://futureis.org/ POLITICAL ENGAGEMENTIndependent Center - Resources for independent political thinking and civic engagement. Link: https://www.independentcenter.org/ GET DAILY NEWSText 844-406-INFO (844-406-4636) with code "purple" to receive quick, unbiased, factual news delivered to your phone every morning via Informed (https://informed.now)Check Out the Unfuck America Tour & National Ground Game: https://www.nationalgroundgame.com/Check Out the CIVICS App to Know More About Your Politicians: https://www.civicpolitics.com ALL LINKShttps://linktr.ee/purplepoliticalbreakdownThe Purple Political Breakdown is committed to fostering productive political dialogue that transcends partisan divides. 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Filippo Pietrantonio from the National Cancer Institute of Milan joins the podcast to discuss the latest developments in RAS targeting in GI cancers, focusing on the exciting data with daraxonrasib in pancreatic cancer ahead of the ASCO 2026 plenary phase 3 data. We discuss the RAS pathway, prior unsuccessful targeting efforts and nuances on response and resistance.

Today on The Amber May Show, Amber is joined by Sam Anthony, owner of YourNews.com, for a powerful conversation about media, politics, justice, and the stories shaping America. We start in Arizona, where the Rattlers crushed the Tucson Sugar Skulls 66-14 in a Mother's Day rivalry blowout. The Rattlers dominated from the start, with a sharp defense, key turnovers, and a standout performance from kicker Matthew Cook. Then we turn to Los Angeles, where a union-backed ad attacking Spencer Pratt may have done the exact opposite of what it intended. The ad framed Pratt as tough on homelessness, supportive of more police officers, and willing to challenge public employee unions. Critics say it may have become one of the best pro-Pratt ads yet. We also break down the latest battle in Virginia, where Democrats are reportedly looking at a court-packing scheme after losing a redistricting fight. The proposal would lower the mandatory judicial retirement age from 73 to 54, forcing out sitting justices and giving the Democrat-controlled legislature the chance to reshape the state Supreme Court. Plus, we discuss the July trial date set for former FBI Director James Comey in the Trump threat prosecution. Prosecutors allege Comey communicated a threat through a social media post involving the numbers “86 47,” while Comey denies threatening the president. From sports to political power plays, from failed campaign attacks to high-profile legal battles, today's show asks a bigger question: who controls the story, and who is finally pushing back? Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, special guest Drew Thomas Allen, author of Clinton Hoax, Obama Coup: The Declassified Story of the Trump-Russia Delusion, joins Amber to unpack the newly declassified story behind the Trump-Russia narrative. For years, Americans were told the Russia collusion story was settled. Now, declassified documents are raising serious questions about the Clinton campaign, the Obama administration, the FBI, the DOJ, and the media machine that pushed the narrative into every corner of American life. Amber and Drew break down how Benghazi, political cover-ups, intelligence warnings, backchannels, and Crossfire Hurricane all connect to one of the biggest political scandals in modern American history. Then Amber turns to the political earthquake happening right now. The Virginia Supreme Court struck down the Democrat-backed redistricting attempt, forcing the old 6-5 congressional map back into place for 2026. Democrats are melting down as Republicans gain the national edge in House ratings. Plus, Tennessee redistricting sparks another media freakout, CNN gets caught flat-footed, Spencer Pratt releases another wild Los Angeles mayoral campaign ad, and the Trump economy shocks the experts by beating job expectations. Today's show asks one big question: When the left loses control of the narrative, the courts, the map, and the economy, what comes next? Get The Book Here https://a.co/d/06WnhD6P Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, special guest Drew Thomas Allen, author of Clinton Hoax, Obama Coup: The Declassified Story of the Trump-Russia Delusion, joins Amber to unpack the newly declassified story behind the Trump-Russia narrative. For years, Americans were told the Russia collusion story was settled. Now, declassified documents are raising serious questions about the Clinton campaign, the Obama administration, the FBI, the DOJ, and the media machine that pushed the narrative into every corner of American life. Amber and Drew break down how Benghazi, political cover-ups, intelligence warnings, backchannels, and Crossfire Hurricane all connect to one of the biggest political scandals in modern American history. Then Amber turns to the political earthquake happening right now. The Virginia Supreme Court struck down the Democrat-backed redistricting attempt, forcing the old 6-5 congressional map back into place for 2026. Democrats are melting down as Republicans gain the national edge in House ratings. Plus, Tennessee redistricting sparks another media freakout, CNN gets caught flat-footed, Spencer Pratt releases another wild Los Angeles mayoral campaign ad, and the Trump economy shocks the experts by beating job expectations. Today's show asks one big question: When the left loses control of the narrative, the courts, the map, and the economy, what comes next? Get The Book Here https://a.co/d/06WnhD6P Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, we ask a hard question: who is protecting America's children? From concerns over long-term SSRI use and PSSD testimony, to juvenile chaos, child exploitation arrests, political scandals, Katie Porter's debate troubles, and Spencer Pratt's viral AI campaign ads, this episode connects the dots between parenting, medicine, leadership, and accountability. Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, Amber is joined by Rob Rene, owner of Exodus Strong, to break down MAHA ELEVATE, the new federal model funding lifestyle medicine, prevention, and whole-person care. Is this a real move toward health freedom, or another government program with strings attached? Amber also covers AI-powered political ads in the LA mayor's race, DOJ subpoenas tied to 2020 election workers, the GOP's identity crisis, New York's tax-the-rich agenda, an ICE child predator case, and the FBI raid involving a powerful Virginia Democrat. Health. Elections. Media. Justice. Power. Who is really looking out for the American people? Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Find Where we air our show here: https://www.ambermayshow.com/

Today on The Amber May Show, Amber is joined by Rob Rene, owner of Exodus Strong, to break down MAHA ELEVATE, the new federal model funding lifestyle medicine, prevention, and whole-person care. Is this a real move toward health freedom, or another government program with strings attached? Amber also covers AI-powered political ads in the LA mayor's race, DOJ subpoenas tied to 2020 election workers, the GOP's identity crisis, New York's tax-the-rich agenda, an ICE child predator case, and the FBI raid involving a powerful Virginia Democrat. Health. Elections. Media. Justice. Power. Who is really looking out for the American people? Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Find Where we air our show here: https://www.ambermayshow.com/

What happens when the stories behind history sound a little too familiar today? On this episode of The Amber May Show, Amber sits down with Robert “Tosh” Plumlee, a former CIA contract pilot who says he was at Dealey Plaza on November 22, 1963, the day President John F. Kennedy was assassinated. Within 48 hours, Tosh was in jail. His life and work took him deep into covert aviation operations across the Caribbean and Latin America, including weapons transfers, intelligence logistics, and clandestine missions tied to Cuba. Also joining the conversation is Ralph Pezzullo, New York Times bestselling author, screenwriter, playwright, and host of Heroes Behind Headlines. Ralph has written more than 30 books, including Jawbreaker, Inside SEAL Team Six, Zero Footprint, Left of Boom, Ghost, and his latest 2025 releases, The Great Chinese Art Heist and Stolen Elections: Takedown of Democracies Worldwide. This is not a history class. This is a hard look at the patterns. Amber asks the questions many Americans are asking right now: How do clandestine operations shape public perception? What can the JFK era teach us about today's intelligence battles? Are we seeing old tactics reused in new political fights? How should Americans view election fraud claims, the Russia hoax, and the assassination attempts against President Trump? Why does the media obsess over the cost of one war while downplaying the cost of another? The conversation also turns to Ukraine, Iran, and the way corporate media frames war spending depending on the political narrative of the moment. From Dealey Plaza to modern election fights, from intelligence operations to media spin, this episode pulls the curtain back on power, secrecy, and the stories Americans are told to believe. https://a.co/d/0i7B3lVI Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Supermassive Black Coffee Use Promocode AMBER https://www.supermassiveblackcoffee.com/ Find Where we air our show here: https://www.ambermayshow.com/

Are you holding back something you know you're supposed to say? Pick Up Your Mic: When God Calls You to Speak. Watch this Wed on IBTV Faith Network @ 3 PM PST, 5 PM CST, 6 PM EST. I sat down with Amber May for a powerful conversation about finding your voice, walking in obedience, and stepping forward when it's not easy. Amber May is the host of The Amber May Show, an independent platform where she speaks into faith, culture, and today's most pressing issues with clarity and conviction. If you've been feeling that pull but haven't taken the step yet, this is for you. Watch on Roku, Apple TV, Fire TV, and online at IBTV. Also available on Rumble on Amber May's channel. Join Me On Telegram https://t.me/theambermayshow Podcast Like A PRO https://podcast-like-a-pro.trainercentralsite.com Promocode Amber Discord https://discord.gg/kUsDba4zRj https://discord.com/channels/1331829063400034435/1331829063869792308 The Amber May Show Theme Song https://suno.com/song/87e27080-4ddb-47f7-8722-b00b251e6c84 Get AMAZING Amber May Merchandise https://www.ambermayshow.com/amazing-products Follow Me on Pickax https://pickax.com/?referralCode=gb4e11n&refSource=copy Get all your My Pillow Products at a DISCOUNT www.mypillow.com/amber Use Promo Code AMBER and save up to 66% off Promo code-AMBER 800-957-2123 Get Ivermectin and hydroxychloroquine and SAVE Dr Stella Immanuel https://shop.drstellamd.com/?linkId=lp_080983&sourceId=amber-may&tenantId=rehoboth-medical-cli Use Promo Code AmberMay and save Become An Affiliate with Dr Stella https://rehoboth-medical-cli.trackdesk.com/sign-up?referralAccountId=1f8c94aa-933e-4aa8-ac5b-5a8d9a0d4508 Save Money When Using A Patient Advocate In The Medical System https://www.graithcare.com/?ref=Amber Take Control of Your Health & Healing! Get the full celebration of solutions that happened at Healing For The A.G.E.S. Over 20 hours of ground-breaking, life-changing, information you've never heard before, and can't get anywhere else! https://healingfortheages.com/ use promocode Amber Patriot Mobile- Free Activation When you become a Patriot Mobile member, your dollars are helping to fund our God-given right to freedom. A portion of every dollar we earn is given back to the causes that support organizations that fight for First Amendment Religious Freedom, Freedom of Speech, Second Amendment Right to Bear Arms, Sanctity of Life, and the needs of our Veterans and First Responders. https://www.patriotmobile.com/amber/ Use Promocode AMBER Our Exodus supplement nourishes your body with potent biblical ingredients, supporting your physical and spiritual journey. Https://exodusstrong.com?a_aid=Amber Become an Exodus Affilate Https://exodusstrong.com/pages/champions?a_aid=Amber The Flynn Movie https://www.flynnmovie.com/ref/azladyz/ War On Truth Movie You've been told that J6 was a violent insurrection against the United States by a group of angry, fringe, MAGA supporters… What if it wasn't? What if there really was a War on Truth? https://hisglory.tv/?ref=448 Promocode MAY Patrick Byrne, the founder/CEO of Overstock.com, rose to the height of financial success and was once heralded as a Wall Street prophet. However, in 2019, Byrne seemingly slipped into madness — stepping down from his multi-billion dollar company, claiming to be a covert government asset trapped in a deadly game of political espionage https://enemywithindocuseries.com/ref/amber Promocode AMBER Is it possible with Turbo Cancers on the rise and Big Pharma's reputation at zero, that Americans are finally ready to hear the truth about Cancer? Are you ready? In the 70's a Doctor working for a National Cancer Institute discovered that Apricot seeds, which contain B-17, actually slowed the growth of tumors. https://rncstore.com/ambermay Ensure the health of the indoor air quality in your home investing in good air purifiers to eliminate pollutants and allergens. Find adjunctive therapies to cancer and better health with red light and methylene blue found in the link below! https://airwaterhealing.com/#May Promocode May Find Where we air our show here: https://www.ambermayshow.com/

“Orthomolecular medicine is about giving the body what it needs to function at its best.” —Dr. Richard Z. ChengThere are many ways to approach health. Some focus on managing symptoms. Others take a step back and look at what the body needs to stay well in the first place.In this episode of the Real Health Podcast, Dr. Ron Hunninghake sits down with Dr. Richard Z. Cheng to discuss how orthomolecular medicine fits into the bigger picture.

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve into a series of significant advancements and regulatory updates that are shaping the future of the industry. At the latest meeting of the American Association for Cancer Research, innovative cancer therapies were in the spotlight. Merck showcased its PD-1xVEGF bispecific antibody for non-small cell lung cancer, combining immune checkpoint inhibition with anti-angiogenic strategies. This novel approach could enhance efficacy and safety compared to existing treatments. Despite these promising developments, Merck remains cautious about disclosing its Phase 3 trial plans, likely due to competitive pressures. The conference also featured industry veterans like Dr. Daniel Chen, who is pioneering "smart" cancer drugs through his startup. These antibody-drug conjugates aim to deliver targeted therapies with precision, minimizing off-target effects—a clear nod towards personalized medicine tailored to the genetic profiles of tumors. Revolution Medicines is making strides in targeting RAS mutations, particularly in pancreatic cancer, with its lead candidate daraxonrasib showing promise in Phase 3 trials. This positions the drug as a potential breakthrough for this challenging cancer type. Their broader pipeline suggests a strategic focus on exploiting RAS pathways, heralding a new wave of targeted cancer therapies. Meanwhile, National Cancer Institute Director Letai reassured attendees about stable research funding amidst political uncertainties, aiming to sustain momentum in cancer research advancements. Regulatory concerns were also a focal point at AACR. Dr. Richard Pazdur expressed anxiety over political influences impacting the U.S. FDA, reflecting broader challenges within regulatory frameworks that could affect drug approval processes and innovation timelines. On an international note, Zai Lab's global expansion ambitions were examined. Transitioning from licensing deals to independent biopharmaceutical development illustrates China's growing influence in biotech, though scaling operations across diverse regulatory environments presents significant challenges. In another significant development, Regeneron secured FDA approval for a pioneering gene therapy, underscoring rapid advances toward personalized therapies for genetic disorders. This marks a new era in genetic medicine and highlights the transformative potential of gene therapy. Meanwhile, Pfizer's strategic post-COVID-19 restructuring has resulted in further layoffs in Ireland, reflecting broader industry trends towards financial recalibration. Such moves underscore the ongoing adjustments companies face as they adapt to post-pandemic market dynamics. Pfizer's strategic portfolio management reflects a trend towards focusing resources on promising late-stage assets while deprioritizing earlier-stage projects that don't align with evolving goals. Roche's oral selective estrogen receptor degrader giredestrant remains a focal point despite clinical data concerns. Positioned as a potential major product in oncology, it illustrates the complexities involved in commercializing promising therapies amid data uncertainties. Sanofi continues to drive growth with Dupixent while preparing legal defenses to extend U.S. exclusivity beyond 2031—a strategic effort to protect revenue streams against generic competition. Conversely, AbbVie's attempt to introduce a Botox successor faced setbacks due to manufacturing-related issues flagged by the FDA, highlighting the complexities of meeting stringent regulatory standards. Avalyn Pharma's $182 million IPO signifies strong investor confidence in late-stage respiratory drug candidates, emphasizing efforts to innovate in chronic disease management. Regulatory dynamics are evolving too, with initiatives aimed at exSupport the show

My guest for this episode is Peter Morville. Peter is a pioneer in the fields of information architecture (IA) and user experience. His bestselling books include Information Architecture, Intertwingled, Search Patterns, Ambient Findability, and Planning for Everything. He has been helping people to plan since 1994, and advises such clients as AT&T, Cisco, Harvard, IBM, the Library of Congress, Macy's, the National Cancer Institute, and Vodafone. He has delivered keynotes and workshops in North America, South America, Europe, Asia, and Australia. His work has been covered by NPR, The Economist, The Washington Post, and The Wall Street Journal. In 2024, Peter founded Sentient Sanctuary, a nonprofit think tank and animal sanctuary, and wrote a philosophical IA novel, Animals Are People. He blogs at intertwingled.org. Peter's IA book has been on my shelf since 1998, when I was a young designer first learning how to design websites (after designing software at IBM and Apple). So, I've been a fan for a long time! He has some intriguing thoughts on the future of tech and the impact of AI on careers, so I know you'll enjoy this episode.SummarySpeaking of AI, here's an AI-generated summary of our podcast transcript. It's kinda good for tasks like this, right? We talk, it listens, and then it summarizes. * AI skepticism has been earned. Peter spent 25 years professionally advising clients to be skeptical of AI hype, and then ChatGPT changed his mind. The lesson: evaluate each wave on its own merits rather than defaulting to either enthusiasm or dismissal. * We're in the fog of war. No one (not the CEOs, nor the researchers) can see clearly beyond the next year or two of AI's trajectory. The smart career move is to keep your eyes and options open rather than betting everything on one prediction about how this unfolds.* Question the motives behind the hype. When tech executives insist AI must permeate everything, consider who profits. As I put it: the CEO of Nvidia telling everyone to use AI is like the CEO of Oreo telling us to eat 50 cookies a day. Follow the money before following the advice.* Technology follows fashion cycles. Peter's observation that tech trends work like fashion is underappreciated. You fight the fashion at your own peril (e.g., resisting Agile during its rise). The skill is learning to ride the wave strategically while waiting to see what actually remains when the dust settles.* AI disruption is exponentially faster this time. Unlike the Industrial Revolution, where ripple effects took generations, this wave is hitting engineering, design, legal, medical, and other white-collar jobs simultaneously. Robotics will soon follow for blue-collar workers. Speed is the new variable that makes historical analogies imperfect.* AI as a coding tool has a hidden failure mode. We discussed a cautionary tale. A veteran CTO went “all in” for 90 days only to find AI-generated code nearly impossible to debug when it broke. Productivity gains can mask a dangerous loss of deep understanding.* Your identity is not your job title or employer. One of the most powerful moments: Peter's deliberate effort to give up being “the information architect” after 25 years, and my coaching exercise of asking people to introduce themselves without mentioning their company or title. The people who can't do it are the most vulnerable to identity collapse in a disruption.* Redefine yourself by going back to childhood. When Peter hit age 40, he started thinking about retiring at 50 to have the freedom to do something else. Initially, he struggled to identify what he would do if money wasn't a motivator. His breakthrough came from remembering what he loved as a kid: animals. That led to a 48-acre farm sanctuary in Virginia. Reconnecting with your pre-career self is a powerful reinvention strategy.* The future belongs to purpose-driven solopreneurs. AI is making it possible for one person to do what used to require a larger team. Combined with the decline of lifelong corporate careers, Peter and I see an opportunity for individuals who build around something they care about, rather than chasing traditional big-company careers. * Ask better questions than “What won't AI automate?” Peter reframed this perfectly: the less obvious and more important questions are Where can I find purpose? What will make me want to get up in the morning? Career resilience in the AI era isn't just about skill-proofing; it's about building a life around meaning that no algorithm can replace. ⬆️ Scroll up and hit play to listen to our conversation. Where to find out more* Intertwingled (Peter's blog) * Sentient Sanctuary (his nonprofit animal sanctuary) Schedule a complimentary call with me if you want to discuss your career goals and how I can help. I'm Larry Cornett, a career coach for ambitious professionals who might be feeling a bit stuck, frustrated, and unfulfilled. Reclaim your confidence to design the life you want and the work you'll enjoy.

Des milliers de personnes mouraient chaque année alors que le remède existe, enfermé dans un coffre-fort quelque part à Langley. C'est l'une des théories complotistes les plus tenaces du monde médical. Tout part d'une réalité historique détournée. En 1951, le National Cancer Institute américain lance un vaste programme de recherche sur les thérapies expérimentales, en pleine Guerre froide. Parallèlement, la CIA mène ses tristement célèbres expériences secrètes — le programme MK-Ultra notamment. Ce mélange de secret d'État et de recherche médicale a semé les graines d'une confusion durable dans l'imaginaire collectif. La date de 1951 n'a aucune origine précise : elle flotte, vague, dans des forums et vidéos complotistes, précisément parce qu'elle est invérifiable — et donc indéfendable, mais aussi indémentable.Pourquoi cette rumeur est-elle fausse ?D'abord, pour une raison biologique fondamentale : le cancer n'est pas une seule maladie. C'est un terme générique qui recouvre plus de 200 pathologies distinctes — cancer du poumon, du sein, du pancréas, leucémies, mélanomes — chacune avec ses mécanismes propres, ses mutations génétiques spécifiques, ses traitements différents. Parler d'un remède contre le cancer en 1951, c'est comme parler d'un médicament qui guérirait à la fois la grippe, le sida et une fracture du crâne. C'est biologiquement absurde.Ensuite, il y a l'argument humain. Les chercheurs en oncologie sont des centaines de milliers dans le monde — à Tokyo, à Paris, à São Paulo, à Berlin. Ils ont des familles. Ils meurent eux aussi du cancer. Croire qu'une conspiration globale tiendrait depuis 75 ans, dans des dizaines de pays, des milliers d'institutions rivales, sans qu'une seule personne ne parle — c'est mathématiquement impossible.Ce que la science dit vraimentLa réalité, c'est que nous avons fait des progrès colossaux. Les immunothérapies, les thérapies ciblées, les inhibiteurs de checkpoint ont transformé le pronostic de nombreux cancers. Certains, autrefois mortels en quelques mois, sont aujourd'hui chroniques ou guérissables.La vérité n'est pas dans un coffre-fort de la CIA. Elle est dans les labos, laborieusement, cellule après cellule. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Patient innovators Liz Salmi and Hugo Campos join The Other 80 to discuss the evolving role of patients in healthcare, using the recent release of ChatGPT Health as a central lens. They delve into how AI is shifting the power dynamic by enabling greater patient agency and creating new expectations for health systems. Drawing on their personal experiences, including Liz's work with OpenNotes and Hugo's long struggle for access to his cardiac device data, they explore how technology can serve as a bridge for collaboration, rather than a source of conflict, between patients and clinicians. Claudia, Liz and Hugo talk about:How patients who are sick and scared often choose sharing over privacyWhy Hugo still can't access his implanted device dataThe need for a new doctor-patient relationship grounded in collaboration, not controlLiz says AI is surfacing the same reactions she saw around patients googling health information:“It makes me think of the Dr. Google era of when clinicians were like, ‘patients shouldn't go online and look for information about their own health because they don't know how to search accurately for their own health information'. And I think we're at this early stage of the tension between health systems wanting to still control how patients find their own health information, versus our own curiosity and exploration of digging into our own health information and… asking the questions that are important to us and then discovering the answers ourselves in our own journey.”Relevant LinksRead Liz and Hugo's paper on Critical AI Health LiteracyWatch Hugo's TEDx Talk on Fighting for the Right to Open His Heart DataLearn more about the patient data transparency movement at OpenNotesRead the full text of the 21st Century Cures ActAbout Our GuestsHugo Campos is an internationally recognized patient advocate, combining creative and technical expertise to promote participatory medicine and patient-centered, AI-enabled healthcare. Named a White House Champion of Change for Precision Medicine by President Obama in 2015, he advocates for patient rights and health data access while managing his own cardiac condition. Hugo serves on the NIH's All of Us Research Program Steering Committee, co-leads patient engagement for PCORI's THRIVE trial, and advises UCSF/UC Berkeley's Computational Precision Health program. A TEDx Cambridge speaker, his advocacy has been featured in national media and scientific publications. Hugo lives in Oakland, California, with his husband, elderly father, and Memphis the cat.SourceLiz Salmi is the Communications & Patient Initiatives Director for OpenNotes. In this role, Liz helps clinicians, hospitals and health systems understand through “the patient's eyes” the changing nature of patient-clinician communication in an age of growing transparency. Her research areas of interest include: the effects of transparency on patient-clinician communication, stakeholder engagement, research dissemination, and the role of social media in patient-clinician-researcher collaborations.As a person living with a low grade malignant brain tumor, Liz is passionate about helping all people engage in their own health care by improving their experience as patients. Over the last 17 years she has been: a research subject; an advisor in patient stakeholder groups; a leader in “patient engagement” research initiatives; and an innovator, educator and investigator in national educational and research projects.In addition to her work with OpenNotes, Liz led the Brain Cancer Quality of Life Collaborative, a multi-stakeholder group dedicated to advancing science and improving the quality of life for people with malignant brain tumors. In fall 2021, members of the BCQoLC team (along with established investigators), were awarded a $12.8 million Center Grant from the National Cancer Institute to determine optimal methods for patient enrollment in a brain tumor registry.SourceConnect With UsFor more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email claudia@theother80.com and follow us on twitter @claudiawilliams and LinkedInSubscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Cases of colorectal cancer in young people have risen nearly 60 percent since the early 2000s. That's according to data from the Centers for Disease Control and the National Cancer Institute. And a new study out this month by the American Cancer Society found that colorectal cancer is now the deadliest kind for those younger than 50.But this rise isn't being felt across all generations in the same way. People born around 1990 are four times more likely to develop rectal cancer than those born around 1950. And for those 65 and older, colorectal cancer rates have actually decreased.So, what's going on? And what can you do to protect yourself and your gut health? For those answers and more, we turn to a panel of experts.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.To manage podcast ad preferences, review the links below:See pcm.adswizz.com for information about our collection and use of personal data for sponsorship and to manage your podcast sponsorship preferences.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Guest Dr. John Gore and host Dr. Davide Soldato discuss JCO article, "12-Month Results from the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent Non-Muscle Invasive Bladder Cancer," which compares radical cystectomy and bladder sparing therapy for patients with recurrent high-grade non-muscle invasive bladder cancer. Dr. Gore and Dr. Soldato focus on the study's patient-centered approach, eligibility criteria, and quality of life after treatment. TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Dr. Davide Soldato: Hello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, medical oncologist at Ospedale San Martino in Genoa, Italy. Today, we are joined by JCO author Dr. John Gore, urologist at Fred Hutch Cancer Center and professor of urology at University of Washington School of Medicine. Today, we will be discussing the article titled, "Twelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non-Muscle-Invasive Bladder Cancer." Thank you for speaking with us, Dr. Gore. Dr. John Gore: Thank you so much for having me. Dr. Davide Soldato: So, I just want to jump right in. We know that patients who are diagnosed with recurrent high-grade non-muscle-invasive bladder cancer can be treated with two different approaches. So, one is radical cystectomy, and the other is bladder-sparing therapy. I just wanted to understand: what was the gap that you were trying to fill with this study? In particular, one point that is very important is that this study is very centered on the preference of the patients. Why did you choose this endpoint instead of going for more solid oncology-based endpoints? Dr. John Gore: Yeah, so CISTO was a study that was derived really organically from patient engagement. I think as a clinical gap in care, making a decision about when to pursue radical cystectomy for patients with non-muscle-invasive bladder cancer is a tough decision for us as clinicians. We did some engagement work partnered with the Bladder Cancer Advocacy Network and my partner Angela Smith, and found that it is also a huge gap for patients. You know, they are very anxious about recurrences, and the decision about when to take out the bladder is a very difficult one. We did an evidence synthesis and found that evidence guiding this decision is fairly limited. The reason we chose more of a patient-reported endpoint is several-fold. One is that we, as part of our engagement work, also worked with our patient survey network to identify outcomes that were important to patients. Some of those are the same outcomes that we care about as clinicians - recurrence-free survival and metastasis-free survival - but several outcomes came out that were more patient-centered. These were patient-reported outcomes such as the burden on my finances, the burden on my caregiver or loved one, and the ability to return to physical activities that are important to them. Part of what is unique about CISTO is that this was a contract with PCORI where we knew we would only have about 12-month outcomes for the majority of our patients. That is too early to really derive a lot of the clinical outcomes, but we are able to answer that patient-centered question of, "Am I going to be able to return to physical activities that are important to me?" And that was the genesis of that as the primary endpoint. Dr. Davide Soldato: So, who were the patients that were eligible to participate in the CISTO trial? What were the key eligibility criteria? This is very particular to this study because this was actually an observational study. Why did you think that such a pragmatic approach still can inform us on what is the best treatment approach for these patients? Dr. John Gore: The intent of CISTO was not necessarily to focus on the tightly defined BCG-unresponsive patient population. That is a clearly important patient population, but every day we are all faced in our real-world practice with patients with challenging, high-grade recurrences that don't fit neatly into that BCG-unresponsive box. The reason we chose a broader inclusion was to help doctors and patients answer these same questions they have when it doesn't fit nicely into this BCG-unresponsive category. You know, maybe their BCG exposure was two years ago, but now they are having a recurrence after intravesical chemotherapy. That is no less challenging a clinical conundrum, and we wanted to be able to enroll those patients. Other key inclusions were that all of the patients in CISTO had to have BCG at some point, and they had to have recent exposure to some adjuvant instillational or intravenous therapy like pembrolizumab. We also had some exclusions that were important. They couldn't be participating in a phase 2 clinical trial, and they couldn't have had a prior upper tract urothelial cancer. The other point about the observational trial design is I think a really important one. Part of our engagement work also asked patients about their willingness to randomize. There is a ton of literature in our history of trials that failed to accrue well when they were comparing a large-scale surgical intervention with a more conservative management strategy. What we found is only about 10% of patients would be willing to randomize when the clinical comparison is between radical cystectomy and bladder-sparing therapy. So it was very clear that an observational study design was the only way we were going to get evidence to inform clinical care when one of the key comparators was radical cystectomy. And so that is why we utilized the observational trial design. Dr. Davide Soldato: Starting to go deeper into the results, you mentioned before that the endpoint you chose for this trial was really centered on what patients thought was more important to them. In particular, the primary endpoint of the study was physical function as measured by the EORTC QLQ-C30 questionnaire. I just wanted to understand: first, did you have a solid hypothesis regarding how physical function could be impacted by either radical cystectomy or bladder-sparing treatments? And second, what were the key results of the study? Dr. John Gore: We figured that at 12 months after enrollment, given the burden and morbidity of a radical cystectomy, that patients in the radical cystectomy arm would have worse self-reported physical functioning than patients in the bladder-sparing therapy arm. We did hypothesize that some of our secondary outcomes might potentially be better after radical cystectomy, such as recurrence-free survival and potentially some other cancer-specific outcomes, because it is a more definitive management strategy. For our primary endpoint, however, we hypothesized that it would be worse. What we found, and the key finding of our study, is that at 12 months after enrollment, physical functioning was not different between patients undergoing radical cystectomy and patients undergoing bladder-sparing therapy, which is just important in terms of clinical counseling because it just means that you can tell your patients, "Gosh, if we could fast-forward your life six to nine months after this procedure, your physical functioning would be similar to as if you had been able to keep your bladder." Dr. Davide Soldato: And you mentioned that there were some key secondary endpoints of the study, which included both other dimensions of quality of life and also hard clinical outcomes. We mentioned metastasis-free survival, for example. Going a little bit into the key secondary quality of life outcomes, we know that radical cystectomy can impact physical functioning, but we also know that bowel, sexual symptoms, and also genitourinary symptoms might potentially be impacted by this type of treatment. We also know that, especially in a system like the US, financial toxicity can be a significant burden for patients. Considering the two different approaches, was radical cystectomy better also in other key secondary quality of life outcomes, and was financial toxicity different between the two arms? Dr. John Gore: Thank you for highlighting some of the really important secondary outcomes that I think are really important to trying to figure out what's best for your patients. Some of the main ones were some of the bladder cancer-specific quality of life outcomes you highlight. Urinary quality of life was worse at enrollment in patients in the radical cystectomy arm but was no different 12 months after. What is unique about how we measure that is we used an instrument called the Bladder Cancer Index because we're comparing a population of patients who have lost their bladder with a population of patients who have retained their bladder, and there are different considerations by gender. And so that instrument is agnostic to urinary diversion status and gender. We found that bowel function and sexual function were worse in the radical cystectomy arm. It appeared that bowel functioning was getting better to the point of near equivalence at 12 months in the radical cystectomy arm but was still inferior to bladder-sparing therapy, and that probably relates to the fact that we use the bowel as part of the urinary diversion, and that causes some transient disruption in bowel function. Financial toxicity is an outcome we weren't initially planning on having as part of the CISTO study, but based on that patient feedback, we made that one of our key secondary outcomes. That actually demonstrated superiority in the radical cystectomy arm. I think it's important that we remember that when we do bladder-sparing therapy, those patients are predisposed to a number of visits to our office, whether they're for instillational therapies or cystoscopy surveillance visits. Sometimes that involves the patient themselves, and sometimes that involves a caregiver. We live in an area with a very large geographic catchment, so sometimes that involves overnight hotel stays and airfare. It can be a particular burden, as you made mention, especially in our healthcare system. Dr. Davide Soldato: Going back to the quality of life dimensions and especially considering the different treatments, 50% of the patients received radical cystectomy with robotic surgery. Did you look a little bit into whether the type of surgery that they received might potentially impact on these dimensions of quality of life? Dr. John Gore: These are some questions that a lot of urologists have asked us in the surgical arm, related to surgical approach, so robotic versus open, and urinary diversion type. We sometimes reconstruct the urinary tract with an incontinent diversion called an ileal conduit where the urine drains tonically into a bag, and we sometimes do a continent diversion where someone typically will have a neobladder, where you reconstruct a sphere reservoir out of intestines and sew it to the urethra. About 20% of patients in the radical cystectomy arm in CISTO had a neobladder. We have not yet looked at specific surgical factors and some of those outcomes. That is one of the secondary analyses that we have planned, but we have not drilled into how different surgical approach factors can affect some of our outcomes. Fortunately, we have about 200 patients in the radical cystectomy arm, so it's enough patients that hopefully we can look at some of those factors in the future. Dr. Davide Soldato: Going back to the clinical endpoints, you mentioned that several of these were measured. There was metastasis-free survival, cancer-specific survival, and progression-free survival. We now have the data at 12 months. I am just wondering if you can comment on those when comparing the radical cystectomy with the bladder-sparing techniques. Dr. John Gore: I think importantly, bladder cancer-specific survival was very high in both arms, over 95% at one year. So both patient populations do very well in terms of cancer-specific and overall survival at one year. You know, when you take out the bladder, you're taking out a big source of recurrences. Not surprisingly, there was a marked reduction in recurrences in the radical cystectomy arm, so they had better recurrence-free survival. There actually was worse progression-free survival in the radical cystectomy arm, but there is a big asterisk to that. As you noted, it is an observational study, and one of the areas of imbalance in the study is that we had higher cancer severity in the radical cystectomy arm. So there was about a 20% rate of progression at the time of radical cystectomy to muscle-invasive and node-positive disease. Of those progressions, the overwhelming majority of them were progressions at the time of radical cystectomy, which I think speaks to a couple of important factors. Number one is the challenge in staging these patients. Our staging of non-muscle-invasive bladder cancer is very reliant on our resection. And so there is this risk of understaging our patients. Number two is just the challenge of decision making, that we fear losing our window of cure in this patient population, which is why we try to steer some patients toward radical cystectomy, and that progression figure kind of speaks to that. Dr. Davide Soldato: Also, one of the factors that was most common in the patients who received radical cystectomy was the presence of other high-risk features. For example, non-urothelial histology, which I think is something that in clinical practice we tend to fear a little bit in terms of recurrence, and so it might potentially bias a little bit towards proposing more strongly radical cystectomy to the patient. Another thing that I wanted to have a comment on, so this is not really in the paper, but I think it speaks a little bit to how the data will evolve over time. Do you imagine these clinical outcomes changing over time, and do you think that with higher maturity of these endpoints, this study might be even more informative when counseling patients regarding what they are obtaining with a radical cystectomy versus the other type of treatments? Dr. John Gore: You know, I think in this cancer universe, 12-month outcomes are great, but I think we all want to see two-year and five-year outcomes. We're very fortunate to supplement the work that we've done in the initial CISTO study, we're very fortunate that we've gotten supplementary funding from the National Cancer Institute to get long-term outcomes in this patient population. So we are continuing to follow all of our CISTO study patients to get two-year and five-year outcomes. What we expect to find is the accrual of new events in the bladder-sparing therapy arm. About 7% of patients in the bladder-sparing therapy arm underwent cystectomy in the first year, but that number will probably go up either as they have recurrences or progression events. We definitely expect the recurrence-free survival to continue to have superiority in the cystectomy arm, but we probably will see the progression events equilibrate as more progression events accrue in the bladder-sparing therapy arm. Maybe by five years, we hypothesize that we'll see clinical superiority in the radical cystectomy arm. By then, we might also see mortality events that separate bladder cancer-specific survival and overall survival between the two arms potentially. But we don't know. Hypothetically, cystectomy has its own downstream risks. It is a major reconstruction with some metabolic sequelae and renal functional sequelae, and so there may be some general medical events that accrue in the cystectomy arm that are also impactful. Dr. Davide Soldato: One other thing that I think should be complimented on this study is that you also looked at several other endpoints that might be important for patients. For example, anxiety symptoms and depression symptoms. Dr. John Gore: Yeah, I think one of the other key secondary outcomes we looked at were mental health outcomes. We utilized the PROMIS domains of anxiety and depression. Not unexpectedly, our radical cystectomy arm patients exhibited higher anxiety symptoms and higher depression symptoms at enrollment. What we found is at 12 months, they actually had significantly lower anxiety and depression than patients in the bladder-sparing therapy arm. We hypothesized in this paper that that actually relates probably mostly to cancer-specific anxiety. You know, when you experience this cavalcade of recurrences, it just breeds an anxiety about adverse cancer-specific outcomes, and by taking out the bladder, you kind of eliminate this prevalent source of anxiety. We followed up the study with a qualitative piece where we interviewed 50 patients and 20 caregivers. Based on those interviews, and that's just a sample of the patient population, it did seem to be cancer-specific anxiety that was driving a lot of those responses. Dr. Davide Soldato: I would like to end with a methodological consideration on your part because we said that this was an observational study. Frequently we tend to think that observational studies come with a lot of bias, and so we tend to downgrade a little bit the results. But I think that a lot of the merit that goes in the CISTO study that was published in the JCO, and I think it also speaks to the fact that this is very high-quality data, comes with the fact that the methodology behind this study was really robust in terms of informing us. Even with this observational study that, as you said, was the only one that we could perform considering the patient population. So just a comment on your part also to speak to the solidity of the data that was published. Dr. John Gore: Importantly, you know, if you look at ClinicalTrials.gov or other sources, CISTO is the only trial that has radical cystectomy as a major comparator. In many ways, this study is our only source of evidence for radical cystectomy. So we'd rather have flawed observational evidence than no evidence at all. We all experience flaws of our RCTs as well. They tend to be these narrowly defined patient populations that may not match the patient in front of you. So I think there are unrecognized flaws on the other side as well. The way that we try to counterbalance that, and none of these techniques are perfect, but we used a strategy called 'targeted maximum likelihood estimation'. Like many methods, such as propensity scores or instrumental variable analysis, what we're trying to do theoretically is coax randomization from non-randomized data. And TMLE, which is the technique we use, tends to be pretty robust to that. So it's the best available way that we can try to counterbalance the bias based on age and clinical severity between the two patient arms. I also think what's important about this is that even when there are biases, I think we are able to infer those out and still extract meaningful details from the data. So even with the biased data, I think we all glean some really important clinical learnings from it. Dr. Davide Soldato: Absolutely, but I would also say that in terms of observational data, the work that you have done is really something that makes us quite confident about what you found in the CISTO study. So with this, I would like to thank you again for joining us today. Dr. John Gore: Thank you so much, and thank you for highlighting the CISTO study. We are very excited about the data. Dr. Davide Soldato: So Dr. Gore, we appreciate you sharing more on your JCO article titled, "Twelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non-Muscle-Invasive Bladder Cancer." If you enjoy our show, please leave us a rating and review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Guest Disclosure Dr. Gore:Consulting or Advisory Role: Astellas Pharma  

Today Liz Dolan interviews Phil Pizzo, the founder of Stanford's Distinguished Careers Institute, a deep thinker on transitions and lifelong learning. His career has taken him from pioneering pediatric oncologist to Dean of Stanford Medical School to rabbinical studies and chaplaincy training. He is a man who thinks a LOT about doing things differently. Welcome to our sponsors: Stanford Federal Credit Union. To use their $620 New Member offer, go to sfcu.org/liznessWelleco. To try The Super Elixir, go to welleco.com and use promo code sisters15 at checkoutHOMEWORK:More on Phil Pizzo, his work and his contributions:The Doctor's Art podcast: An episode called Courage and Curiosity Discussion of what drew him to medicine in the first place with more about his work caring for seriously ill children and his pioneering work at the National Cancer Institute.Stanford Daily: Phil Pizzo moves from Stanford Medical School to rabbinical studies https://stanforddaily.com/2022/04/10/from-stanford-to-the-rabbinate-phil-pizzo-moving-on/The Atlantic The New Old Age by David Brooks. What a new life stage can teach us about how to find meaning and purpose. Corrected book title from last episode: Turn Right at Machu Picchu: Rediscovering The Lost City One Step At A Time from 2021. A fascinating and funny account of a journalist's travels through some of the world's most majestic, historic, and remote landscapes.If you are new to Lizness School, we suggest you listen to Season 1 to hear all about Liz's year as a Stanford Fellow. Everything from Neuroscience and Chinese History to Pickleball! Plus a great community experience with her fellow DCI Fellows.Season 2 is about how she puts her lessons to work in the wild with the help of her millennial mentor Leah Sutherland.To listen to Liz +. Leah's recap of Lizness School Season 1, go to our FINALE here.For more on Liz Dolan, go to ⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠For more on Liz's work in podcasting, go to ⁠⁠⁠⁠Satellite Sisters⁠⁠⁠⁠Follow Lizness School on all podcasting platforms including ⁠⁠⁠⁠Apple Podcasts⁠⁠⁠⁠ and ⁠⁠⁠⁠Spotify.⁠⁠⁠⁠On Instagram, follow the show at ⁠⁠⁠⁠https://www.instagram.com/liznessschool/⁠⁠⁠⁠ and follow Liz at ⁠⁠⁠⁠https://www.instagram.com/satellitesisterliz/⁠⁠⁠⁠.Follow Producer and Millennial Mentor Leah Sutherland @leahhsutherlandd on Instagram and Leah Sutherland on LinkedIn. To email Lizness School with your own voice memos/questions/thoughts/suggestions for Liz or Leah, use ⁠⁠⁠⁠liznessschool@gmail.comThe Distinguished Careers Institute is a unique program for late career people. Fellows are graduate students at Stanford University, able to take classes in any area. ⁠⁠⁠⁠Complete information here.⁠⁠⁠⁠Email the podcast ⁠⁠⁠⁠liznessschool@gmail.com ⁠See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Approximately 5–10% of all breast cancers are hereditary, and among those, BRCA1 and BRCA2 mutations are responsible for about 60% of cases. Yet, overall, only about 1-2% of all breast cancers in the general population are caused by BRCA mutations. Once childbearing is complete, the NCCN recommends risk-reducing BSO in patients carrying these mutations. But what about the uterus? Since childbearing is complete, and the ovaries are now removed, the sole purpose of the uterus- which is to initiate, nourish, and grow a child -is no longer applicable. Is there a call for inclusion of a hysterectomy at time of risk reducing BSO? This has vast and important implications regarding subsequent hormone therapy. In this episode, which comes from one of our podcast family members, we will dive into the latest data pushing towards the inclusion of hysterectomy at time of prophylactic BSO. It's fascinating data from just last year (2025, in the Journal of the NCI). Listen in for details.1. Kotsopoulos J, Seca M, Gronwald J, et al. Menopausal Hormone Therapy and the Risk of Breast Cancer in Women With a Pathogenic Variant in BRCA1 or BRCA2. Journal of the National Cancer Institute. 2025. 2. Kotsopoulos J, Gronwald J, Karlan BY, et al. Hormone Replacement Therapy After Oophorectomy and Breast Cancer Risk Among BRCA1 Mutation Carriers. JAMA Oncology. 2018

Host Dr. Davide Soldato and guests Dr. David Einstein and Dr. Ravi Madan discuss JCO article, "National Cancer Institute's Working Group on Biochemically Recurrent Prostate Cancer: Clinical Trial Design Considerations," underscoring the need for a consensus on clinical trial designs implementing novel endpoints in this population, the importance of PSA doubling time as a prognostic factor and with an emphasis on treatment de-escalation to limit toxicity and improve patient outcomes. TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Davide Soldato: Hello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, medical oncologist at Ospedale San Martino in Genoa, Italy. Today, we are joined by JCO authors Dr. David Einstein and Dr. Ravi Madan. Dr. Einstein is a medical oncologist specializing in genitourinary malignancy working at Beth Israel Deaconess Medical Center, part of the DFCI Cancer Center, and an assistant professor at Harvard Medical School. Dr. Madan is a senior clinician at the National Cancer Institute (NCI), where he focuses on conducting clinical research in prostate cancer, particularly in the field of immunotherapy. Today, we will be discussing the article titled, "National Cancer Institute's Working Group on Biochemically Recurrent Prostate Cancer: Clinical Trial Design Considerations." So, thank you for speaking with us, Dr. Einstein and Dr. Madan. David Einstein: Thanks for having us. This is a great pleasure. Ravi Madan: Appreciate being here. Davide Soldato: So, I just want to start from a very wide angle. And the main question is why did you feel that there was the need to convey a consensus and a working group to talk about this specific topic: biochemically recurrent prostate cancer? What has been the change in current clinical practice and in the trial design that we are seeing nowadays? And so, why was it necessary to convey such a consensus and provide considerations on novel clinical trials? David Einstein: Yeah, so I think it's very interesting, this disease state of biochemically recurrent prostate cancer. It's very different from other disease states in prostate cancer, and we felt that there was a real need to define those differences in clinical trials. Years ago, metastatic castration-resistant prostate cancer was the primary disease state that was explored, and over time, a lot of things shifted earlier to metastatic disease defined on a CAT scan and bone scan to an earlier disease state of metastatic castration-sensitive prostate cancer. And the clinical trial principles from late-stage could be applied to MCSPC as well. However, BCR is very different because the patients are very different. And for those reasons, there are unique considerations, especially in terms of toxicity and treatment intensity, that should be applied to biochemically recurrent prostate cancer as opposed to just using the principles that are used in other disease states. And for that reason, we thought it was very important to delineate some of these considerations in this paper with a group of experts. Davide Soldato: Thanks so much. So, one of the main changes that have been applied in recent years in clinical practice when looking at biochemically recurrent prostate cancer is the use of molecular imaging and particularly of PSMA PET. So, first of all, just a quick question: was the topic of the consensus related on which threshold of PSA to use to order a PET scan to evaluate this kind of patient? David Einstein: Yeah, thanks for that question. It's a super important one. The brief answer is that no, we did not address questions about exactly when clinicians would decide to order scans. We were more concerned with the results of those scans in how you define different disease states. But I think as a broader question, I think a lot of folks feel that finding things on a scan equates that with what we used to find on conventional scans. And fundamentally, we actually sought to redefine that disease space as something that's not equivalent to metastatic disease, and rather coined the term "PSMA-positive BCR" to indicate that traditional BCR prognostic criteria and factors still apply, and that these patients have a distinct natural history from those with more advanced metastatic disease. Ravi Madan: And if I may just add that the National Cancer Institute is running a trial where we're prospectively monitoring PSMA-positive BCR patients. And that data is clearly showing that, much like what we knew about BCR a decade ago, PSMA findings in BCR patients do not change the fact that overall, BCR is an indolent disease state. And the findings, which are usually comprised of five- to seven-millimeter lymph nodes, do not endanger patients or require immediate therapy. And so, while PSMA is a tool that we can be using in this disease state, it doesn't really change the principal approach to how we should manage these patients. And as Dr. Einstein alluded to, there is a drive to create a false equivalency between PSMA-positive BCR and metastatic castration-sensitive prostate cancer, but that is not supported by the data we're accumulating or any of the clinical data as it exists. Davide Soldato: One thing that it's very important and you mentioned in your answer to my question was actually the role of PET scan and conventional imaging, so CAT scan and bone scan that we have used for years to stage patients with metastatic prostate cancer. And you mentioned that there is a distinction among patients who have a positive PET scan and a BCR, and patients who have a positive conventional imaging. And yet, we know that sometimes the findings of the PET scan are not always so clear to interpret. So, I just wanted to understand if the consensus reached an agreement as to when to use conventional imaging to potentially resolve some findings that we have on PET scan among thess patients with BCR? David Einstein: Yeah, I think there's a number of questions actually buried within that question. One of which is: does PSMA PET result in false positives? And the answer has definitely been yes. There's a known issue with false-positive rib lesions. And so, first and foremost, we need to be very careful in calling what truly is suspicious disease and what might actually not be cancer or might be something that is totally separate. So I think that's the first part of the answer to that question. The second is to what extent do we need to use paired PET and conventional imaging to define this disease state? In other words, do you have to have positive findings on one and negative findings on the other in order to enter this definition? The challenge there, as we discussed, is that logistically, oftentimes it's hard to get patients to do multiple sets of scans to actually create that definition. Sometimes it's difficult to get insurers to pay for such scans. And finally, it's hard to sometimes blind radiologists to the results of one scan in reading the other. So, we did have some deliberations about to what extent you could use some of the CAT scan portion of a PSMA PET in order to at least partially define that. We also talked about using bone scans to confirm any bone findings seen on PET. But I think another important part of this is not just the baseline imaging, but also what's going to be done serially on a study in order to define responses and progression. And that's sort of a whole separate conversation about to what extent you can interpret changes in serial PET. Ravi Madan: And just to pick up on the key factor here, I think that the PSMA PET in BCR is pretty good at defining lymph node disease, and that's actually predominantly 80 to 90 percent of the disease seen on these findings. It might be pretty good at also defining other soft tissue findings. The real issues come to bone findings. And one thing the group did not feel was appropriate was to just define only PSMA-positive bone findings confirmed on a CT bone window. There's not really great data on that, but the working group felt that, when in the rare situation, because it is relatively rare, a PSMA-positive finding is in a bone, a bone scan should be done. And it's worth noting that Phu Tran, who is a co-author and a co-leader of this working group, his group has already defined that underlying genomics of conventionally based lesions, such as bone scan, are more aggressive than findings on next-gen imaging, such as PSMA. So, there is also a genomic underlying rationale for defining the difference between what is seen on a PET scan in a bone and what is seen on a bone scan. Davide Soldato: Coming back to this issue of PET PSMA sometimes identifying very small lesions where we don't see any kind of correlates on conventional imaging or where we see only very little alteration on the bone scan or in the CT scan, was there any role that was imagined, for example, for MRI to distinguish this type of findings on the PET scan? Ravi Madan: So, I think that, again, what can be identified on a PSMA frequently cannot be seen on conventional imaging. We didn't feel that it was a requirement to get an MRI or a CT to necessarily confirm the PSMA findings. I think that generally, we have to realize that in this disease state, that questionable lesions are going to be seen on any imaging, including PSMA. We've actually probably put way too much faith in PSMA findings thus far, as Dr. Einstein alluded to with some of the false positives we're seeing. So, I think that these false positives are going to have to be baked into trials. And in terms of clinical practice, it highlights the need to again, not overreact to everything we see and not necessarily need to biopsy everything and put patients' health in jeopardy to delineate a disease that's indolent anyway. Davide Soldato: Thanks so much. That was very clear. So, basically, the main driver was really also the data showing that if we have a BCR, so a patient with a biochemically recurrent disease that is positive on the conventional imaging, this is usually associated with a different aggressiveness of the disease. But coming back to a comment that you made before, Dr. Madan, you said that even if we talk about PSMA-positive BCR, we are still talking about BCR and the same criteria should apply. So, what we have used for years in this space to actually try to stratify the prognosis of patients is the PSA doubling time, so how quickly the PSA rises over time. So, coming back to that comment, was the consensus on the PSA doubling time basically retained as what we were using before, so defining patients with a doubling time less than 12 months, 10 months, 9 months, as patients with a higher risk of progressing in terms of developing metastatic disease? Ravi Madan: Yes, so that's a very important point. And the working group defined high-risk BCR as a PSA doubling time less than six months. And this really comes from Johns Hopkins historical data, which shows that if your doubling time is three months or less, there's about a 67 percent chance of metastasis at five years. If it's between three and six months, it's 50 percent. And if it's over six months, if it's between six and nine months, it's roughly only 27 percent. There are trials that are accruing with eligibility criteria that they may describe as high-risk that are beyond six months, but the data as really it's been defined in the literature highlights that truly high-risk BCR is less than six months. And the working group had a consensus on that opinion, and that was our recommendation. David Einstein: And I think an important follow-on to that is that's regardless of PET findings, right? And so, we present a couple of case studies of patients with positive PET findings who have a long doubling time, in whom the disease is in fact indolent, as you would have expected from a traditional BCR prognostic standpoint. Obviously, there are patients in whom they have fast doubling times, and even if they do not have PET findings, that doesn't make them not high-risk. Ravi Madan: And just to follow up that point, I will let you know a little bit of a free preview that my colleague Melissa Abel from the NCI will be presenting PSMA findings in the context of PSA doubling time at ASCO GU if that data is accepted. Davide Soldato: Looking forward for those data because I think that they're going to clarify a lot of the findings that we have in this specific population. And coming back to one of the points that we made before, so PET PSMA has a very high ability to discriminate also a very low burden of disease, which we currently refer to as oligometastatic biochemically recurrent prostate cancer, which is not entirely defined as an entity. But what we are seeing both in some clinical trials, which use mainly conventional imaging, but also what we're starting to see in clinical practice, is that frequently we use the metastasis-directed therapy to treat these patients. So, just a little bit of a comment on the use of this type of strategy in clinical practice and if the panel thought of including this as, for example, a stratification criteria or mandated in the design of novel clinical trials in the field of BCR? David Einstein: Yeah, I think that's an incredibly important point. You know, fundamentally, there's a lot of heterogeneity in practice where some folks are using local salvage approaches, some are using systemic therapies, in some cases surveillance may be reasonable, or some combination of these different strategies. We certainly have phase two data from multiple trials suggesting that met-directed therapy may help buy patients time off of treatment until subsequent treatments are started. And that in and of itself may be an important goal that we can come back to in discussing novel endpoints. I think what our panel acknowledged was that, in some sense, the clinical practice has gotten even farther ahead than where the data are, and this is being offered pretty routinely to patients in practice. And so, what became clear was that we, in developing clinical trials, cannot forbid investigators from doing something that would be within their usual standard of care, even if it might not be supported by the most robust data. But at minimum, it definitely should be used as a stratification factor, or in some trial designs, you can do met-directed therapy after a primary endpoint is assessed. And that offers a compromise between testing, say, the effect of a systemic therapy but also not excluding patients and investigators from doing what they would have done had they not been on a study. Ravi Madan: And I would just like to follow up your phrasing in the question of "oligometastatic prostate cancer." We have a figure in the paper and it highlights the fact that, unfortunately, that term in prostate cancer is imaging agnostic. And we've already discussed in this podcast, as well as in the paper, that imaging used to define a metastatic lesion, whether it's PSMA or conventional imaging, carries with it a different clinical weight and a different prognosis. So, we feel in the working group, that the correct term for this disease state of PSMA-positive BCR is just that: PSMA-positive BCR. We also have to realize that when we talk about oligometastatic disease, while it's imaging agnostic, it seems to be numerically based, whether it's five or three or 10 depending on the trial. But PSMA-positive BCR does not have a limit in terms of the number of lesions. And so again, we just feel that there is an important need to delineate what we're seeing in this disease state, which again is PSMA-positive BCR, and that should be differentiated frankly from oligometastatic disease defined on other imaging platforms. David Einstein: Right, and that also makes clear that patients can have polyfocal disease on PET that still is not what we would consider metastatic, but goes beyond the traditional definition of oligometastatic. So, in other words, just because someone has PET-detected disease only, that does not automatically equate with oligometastatic. Davide Soldato: Thanks so much. So, you were speaking a little bit, Dr. Einstein, about the different types of treatment that we can propose or not propose to this patient because you mentioned, for example, that in clinical practice MDT, so metastasis-directed therapy, is becoming more and more used. For these patients, we can potentially use systemic treatments, which include androgen deprivation therapy, which can be given continuously or in an intermittent fashion. And recently, we can also use novel systemic therapies, for example, enzalutamide, to treat this type of patient. So, given that the point of the consensus was really to provide consideration for novel clinical trials in this space, what was the opinion on the panel regarding the control arm? So, if we're looking at a novel therapy in the BCR space, does the control arm need to include a therapy or not? And if so, which therapy? David Einstein: Yeah, this is a super important question and one that's subject to a lot of discussion, especially in light of recent data from EMBARK. What we came to a consensus around was the fact that neither MDT nor systemic therapy should be required as a control arm on BCR trials. And we can talk about a number of reasons for that. There's also the pragmatics of what investigators might actually accrue patients to and what they would consider their standard of care, and that's important to factor in, too. I think that one of the major goals of our working group was outlining what kinds of trials we would like to see in the future and where the limitations of the current data stand. For example, EMBARK proposes a strategy of a single treatment discontinuation and resumption at a predefined threshold indefinitely. That's probably not how most people are practicing. Most folks are probably using some version of intermittent therapy as they would have before this trial, but we actually don't have any data supporting that. Moreover, we don't have data comparing different intermittent strategies to one another. We don't know what the right thresholds are, we don't know how much time we buy patients off treatment, and we don't know to what extent MDT modifies that. And so, those are all really important questions to be asking in future versions of these trials. I'd say my second point would be that a lot of drug development is happening with novel therapies that are not hormonal, trying to bring them into this space. And when you think about trying to compare one of those types of therapies to a hormonal therapy on short-term endpoints, the hormonal therapy is always going to win. Hormonal therapy is almost universally effective, it will bring down PSAs, and it will prolong, quote-unquote, "progression." The downside of that is that hormonal therapy doesn't actually modify the disease, it suppresses it, and it tends to have fairly transient effects once you remove it. And so, part of our goal was in trying to figure out some novel endpoints that would allow these novel types of therapies to be examined head-to-head against a more traditional type of hormonal therapy and have some measurement of some of the more long-term impacts. Davide Soldato: So, jumping right into the endpoints, because this is a very relevant and I think very well-constructed part of the paper that you published. Because in the past we have used some of these endpoints, for example, metastasis-free survival, as potentially a proxy for long-term outcomes. But is this the right endpoint to be using right now, especially considering that frequently this outcome is measured using conventional imaging, but we are including in these trials patients who are actually negative on conventional imaging but have a positive PSMA when they enter this type of trial? David Einstein: Yeah, there's a number of challenges with those types of endpoints. One of which is, as you say, we're changing the goalposts a little bit on how we're calling progression. We still don't exactly understand what progression on PET means, and so that's something that is challenging. That said, we're also cognizant of the fact that many times investigators are likely to get PET scans in the setting of rising PSA, and that's going to affect any endpoint that relies purely on conventional imaging. So, there's some tension there between these two different sets of goalposts. One thing that we emphasize is that not only are there some challenges in defining those, but also there're challenges in what matters to a patient. So, if a progression event occurs in the form of a single lesion on a PET scan or even a conventional image, that might be relevant for a clinical trial but might be less relevant for a patient. In other words, that's something that, in the real world, an investigator might use serial rounds of metastasis-directed therapy or intermittent therapy to treat in a way that doesn't have any clinical consequences for the patient necessarily. In other words, they're asymptomatic, it's not the equivalent of a metastatic castration-resistant disease progressing. And so, we also need to be cognizant of the fact that if we choose a single endpoint like PFS, that there's going to be many different versions of progression, some of which probably matter clinically more than others, and some of which are more salvageable by local therapies than others. Ravi Madan: So I think the working group really thoughtfully looked at the different options and underscored perhaps strengths and weaknesses, and I think that's presented as you mentioned in the paper. But I think it's also going to depend on the modality, the approach of the therapeutic intervention. In some cases if it's hormone-based, then maybe PSA is providing some early metrics, maybe metastasis-free survival is more relevant in a continuous therapy, but intermittent therapies might have a different approach. There's emerging immunotherapy strategies, radiopharmaceutical strategies, they might have some more novel strategies as well. I think we have to be open-minded here, but we also have to be very clear: we do not know what progression is on a PSMA scan. Just new lesions may not carry the clinical significance that we think, and we may not know what threshold that ultimately becomes clinically relevant is. So, I do think that there was some caution issued by the working group about using PSMA as an endpoint because we still do not have the data to understand what that modality is telling us. Again, I'm optimistic that the National Cancer Institute's prospective data set that we've been collecting, which has over 130 patients now, will provide some insights in the months and years ahead. Davide Soldato: So, just to ask the question very abruptly, what would you feel like the best endpoint for this type of trials is? I understand that is a little bit related to the type of treatments that we're going to use, whether it's intermittent, whether it's continuous, but do we have something that can encapsulate all of the discussion that we have up until this point? David Einstein: Yeah, so that's a perfect segue to the idea of novel endpoints, which we feel are very important to develop in these novel disease spaces. So, one thing that we discussed was an endpoint called treatment-free survival, which conceptually you can think of as exactly what it sounds like, but statistically you actually have to do some work to get there. And so essentially, you imagine a series of Kaplan-Meier curves overlaid: one about overall survival, one time to next therapy, one time on initial therapy. You can actually then take the area under those curves or between those curves and essentially sum it up using restricted mean survival time analysis. And that can give you a guide about the longitudinal experience of a patient: time spent on treatment versus off treatment; time spent with toxicity versus without toxicity. And importantly, each one of those time-to-event metrics can be adjusted depending on exactly what the protocol is and what is allowed or not allowed and what's prespecified as far as initiation of subsequent therapies. So, we felt that this was a really important endpoint to develop in this disease space because it can really capture that longitudinal aspect. It can really reward treatments that are effective in getting durable responses and getting patients off of therapy, because unfortunately, PFS-based endpoints generally reward more or longer systemic therapy versus shorter or no systemic therapy, and that's sort of an artificial bias in the way those endpoints are constructed. So, I think that there are challenges of course in implementing any new endpoint, and some of the things that are really critical are collecting data about toxicity and about subsequent therapies beyond what a typical trial might collect. But I think in this kind of disease space, that longitudinal aspect is critical because these are really patients who are going to be going through multiple rounds of therapy, going to be going on and off treatments, they're going to be using combinations of local and systemic therapies. And so, any one single endpoint is going to be limited, but I think that really highlights the limitations of using PFS-based endpoints in this space. Ravi Madan: I also think that in the concept of treatment-free survival lies one of the more powerful and, honestly, I was surprised by this, that it was so universally accepted, recommendations from the committee. And that was that the general approach to trials in this space should be a de-escalation of the EMBARK strategy as it's laid out with relatively continuous therapy with one pause. And so, I think again, buried in all of this highlights the need for novel endpoints like treatment-free survival. We get to the fact that these are patients who are not at near-term clinical risk from symptoms of their disease, so de-escalating therapies does not put them at risk. And if you look at, for example, lower-volume metastatic castration-sensitive prostate cancer, it's become realized that we need to de-escalate, and there are now trials being done to look at that. Historically, we know that BCR is an indolent disease process for the vast majority of patients who are not at near-term risk from clinical deterioration. So, therefore, we shouldn't wait a decade into abundant BCR trials to de-escalate. The de-escalation strategy should be from the outset. And that was something the committee really actually universally agreed on. David Einstein: And that de-escalation can really take multiple forms. That could be different strategies for intermittent therapy, different start-stop strategies. It could also mean actually intensifying in the short-term with the goal long-term de-intensification, kind of analogous to kidney cancer where we might use dual checkpoint inhibitors up front with some higher upfront toxicity but with the hope of actually long-term benefit and actually being able to come off treatment and stay in remission. Those kinds of trade-offs are the types of things that are challenging to talk about. There's not a one-size-fits-all answer for every patient. And so, that's why some of these endpoints like treatment-free survival would be really helpful in actually quantifying those trade-offs and allowing each patient to make decisions that are concordant with their own wishes. Davide Soldato: Thanks so much. That was very clear, especially on the part of de-escalation, because, as you were mentioning, I think that we are globally talking about a situation, a clinical situation, where the prognosis can be very good and patients can stay off treatment for a very long period of time without compromising long-term outcomes. And I think that well-constructed de-escalation trials, as you were mentioning and as the consensus endorsed, are really needed in this space also to limit toxicity. This brings us to the end of this episode. So, I would like to thank again Dr. Einstein and Dr. Madan for joining us today. David Einstein: We really appreciate the time and the thought, and I think that even starting these types of discussions is critical. Even just recognizing that this is a unique space is the beginning of the conversation. Ravi Madan: Yeah, and I want to thank JCO for giving us this forum and the opportunity to publish these results and all the expert prostate cancer investigators who were part of this committee. We produced some good thoughts for the future. Davide Soldato: We appreciate you sharing more on your JCO article titled, "National Cancer Institute's Working Group on Biochemically Recurrent Prostate Cancer: Clinical Trial Design Considerations." If you enjoy our show, please leave us a rating and review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinion of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

How do breakthroughs in the lab become real-world treatments that save lives? In this episode, Professor Stephen Maher of Trinity College Dublin joins us to discuss the rapidly evolving field of translational oncology and how cutting-edge research is shaping the future of cancer therapy. As a leading expert in radiation research and Director of Postgraduate Studies for the School of Medicine at Trinity, Stephen focuses on a critical question: why do some cancers respond to treatment while others resist it? His work examines the role of microRNAs, tumor hypoxia, and DNA damage response in shaping how cancers react to chemotherapy and radiotherapy — with particular attention to oesophageal and pancreatic cancers. In this episode, we explore: ·       Where anti-cancer therapeutics are headed in the coming years ·       How radiation research is evolving to improve treatment precision ·       Why translational oncology is essential for turning discovery into patient care ·       How treatment resistance forms — and what researchers are doing to overcome it After earning his Ph.D. in Oncology at RCSI and completing a fellowship at the National Cancer Institute in Maryland, Professor Maher has dedicated his career to bridging the gap between scientific discovery and clinical impact. He leads major national and international collaborations and has helped build advanced radiotherapy and hypoxia research programs at Trinity's Translational Medicine Institute. Learn more about Professor Maher and his work here. Episode also available on Apple Podcasts: https://apple.co/38oMlMr 

Karen J. Wernli, PhD, joins CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss her research into additional health communication to improve patient knowledge of lung cancer screening timeliness.  DOI: 10.1016/j.chest.2025.07.4111 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.       Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R01CA262015. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. 

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In today's episode, we are joined by Professor Stephen Maher, an expert in translational oncology and radiation research at Trinity College Dublin, where he also serves as the Director of Postgraduate Studies for the School of Medicine. Stephen's work focuses on understanding why some cancers respond to treatment while others resist it — particularly in relation to chemotherapy and radiotherapy. His research explores how factors like microRNAs, the DNA damage response, and tumor hypoxia influence treatment sensitivity, with a strong emphasis on oesophageal and pancreatic cancers. Hit play to explore: The future of anti-cancer therapeutics. The ways that radiation research is evolving. Why translational oncology is so important for improving patient outcomes. After completing his Ph.D. in Oncology at RCSI and a fellowship at the National Cancer Institute in Maryland, Stephen has built a career dedicated to bridging lab-based discovery with patient-focused care. He leads national and international collaborations in cancer biology and has helped develop cutting-edge radiotherapy and hypoxia research cores at Trinity's Translational Medicine Institute. Click here to learn more about Stephen and his important work!