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In this episode of the Epigenetics Podcast, we talked with Mo Motamedi from the Center for Cancer Research at Massachusetts General Hospital about his work on RNA-mediated epigenetic regulation. The Interview starts with Dr. Motamedi sharing his personal journey into the realm of biology, sparked by a familial inclination towards science and a challenge to excel in a field that initially felt daunting. His passion was ignited during a genetics class, as he recognized the quantitative nature of the discipline amidst the evolution of modern techniques like qPCR and high-throughput sequencing. Dr. Motamedi goes on to articulate the importance of understanding the interplay between genetics and broader biological systems, emphasizing that an insightful grasp of evolution is vital for decoding cellular mechanisms. He reflects on his time in a postdoctoral lab under Danish Moazet, investigating RNA interference (RNAi) and its unexpected nuclear roles, contributing significantly to the understanding of how RNAi is involved in gene silencing via chromatin interaction. As his narrative unfolds, Dr. Motamedi provides deep insights into his own lab's work, which focuses on the establishment and maintenance of epigenetic states and their implications in cancer epigenetics. He discusses groundbreaking discoveries related to RNAi and heterochromatin, detailing experiments that unveil how specific proteins contribute to transcriptional and post-transcriptional gene silencing. A pivotal theme emerges: the complex dynamics of genome evolution and chromatin organization can be reshaped under various biological contexts, including the quiescent state of cells under stress. Moreover, the discussion traverses recent publications from Dr. Motamedi's lab, revealing how they identify long non-coding RNAs that function as silencers at centromeres, an essential mechanism that aids in the establishment of heterochromatin independently of RNAi. His findings advocate for the idea that well-structured genome organization can lead to more efficient gene regulation, which can also be crucial in therapeutic contexts for various cancers. References Motamedi, M. R., Hong, E. J., Li, X., Gerber, S., Denison, C., Gygi, S., & Moazed, D. (2008). HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Molecular cell, 32(6), 778–790. https://doi.org/10.1016/j.molcel.2008.10.026 Joh, R. I., Khanduja, J. S., Calvo, I. A., Mistry, M., Palmieri, C. M., Savol, A. J., Ho Sui, S. J., Sadreyev, R. I., Aryee, M. J., & Motamedi, M. (2016). Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs. Molecular cell, 64(6), 1088–1101. https://doi.org/10.1016/j.molcel.2016.11.020 Joh, R. I., Lawrence, M. S., Aryee, M. J., & Motamedi, M. (2021). Gene clustering drives the transcriptional coherence of disparate biological processes in eukaryotes. Systems Biology. https://doi.org/10.1101/2021.04.17.440292 Related Episodes Evolutionary Forces Shaping Mammalian Gene Regulation (Emily Wong) Chromatin Evolution (Arnau Sebé-Pedrós) The Role of lncRNAs in Tumor Growth and Treatment (Sarah Diermeier) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Guest: Michael Levy, MD, PhD Antibody-mediated demyelinating diseases, such as neuromyelitis optica spectrum disorder and MOG antibody disease, differ fundamentally from multiple sclerosis (MS) due to their association with specific antibodies. Dr. Michael Levy explains how these conditions progress, how relapses can drive disability, and why prevention is critical for improving long-term outcomes. Dr. Levy is an Associate Professor at Harvard Medical School working in the Department of Neurology at Brigham and Women's Hospital, and he spoke about this topic at the 2025 European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress.
Guest: Michael Levy, MD, PhD Antibody-mediated demyelinating diseases, such as neuromyelitis optica spectrum disorder and MOG antibody disease, differ fundamentally from multiple sclerosis (MS) due to their association with specific antibodies. Dr. Michael Levy explains how these conditions progress, how relapses can drive disability, and why prevention is critical for improving long-term outcomes. Dr. Levy is an Associate Professor at Harvard Medical School working in the Department of Neurology at Brigham and Women's Hospital, and he spoke about this topic at the 2025 European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress.
Join Professor Iain McInnes for the latest episode of Discussing RA on The Immune-Mediated Inflammatory Disease Forum. In this episode, he highlights two papers: risk of MACE, VTE, and malignancies in patients with RA or UC treated with filgotinib and frequency of reporting of MACE, MI, and stroke between JAKis and anti-TNFα.
Interview with Sharmili Edwin Thanarajah, MD, author of Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations. Hosted by John Torous, MD. Related Content: Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations GLP-1 Receptor Agonists for Pharmacologically Induced Weight Gain
Interview with Sharmili Edwin Thanarajah, MD, author of Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations. Hosted by John Torous, MD. Related Content: Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations GLP-1 Receptor Agonists for Pharmacologically Induced Weight Gain
Our 21st century digital age provides countless and unprecedented opportunities for identity development and cultural engagement. But how might these new means of social interaction impact religious institutions and their public image?On today's episode of Scholars & Saints, host Nicholas Shrum seeks out these answers with the help of Oklahoma State University's Professor of Media and Strategic Communications Rosemary Avance. In her recent book, Mediated Mormons: Shifting Religious Identities in the Digital Age, Avance explores how the Church of Jesus Christ of Latter-day Saints created and negotiated its public image during the "Mormon Moment" of the 2010's. Avance and Shrum discuss the different media focuses during this period, including Mitt Romney's 2012 presidential campaign, online discussions around caffeine, the Gospel Topics Essays, and more.You can learn more about Rosemary Avance, her research, and her academic interests by visiting her faculty page.
Join Professor Iain McInnes as he discusses the top publications in the world of RA. This month's discussion covered the ‘Efficacy and safety of upadacitinib for patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis'. Read the full paper summary online at www.imidforum.com.
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Suture-Mediated Patent Fossa Ovalis Closure: Late Clinical Outcomes and Predictors of Technical Success.
In this episode, host Alyssa Watson, DVM, welcomes back John M. Thomason, DVM, MS, DACVIM (SAIM), to talk about his recent Clinician's Brief article, “Top 4 Primary Immune-Mediated Disorders in Dogs.” In part 2 of this 2-part conversation, Dr. Thomason focuses on immune-mediated polyarthritis (IMPA) and pemphigus foliaceus. He covers some diverse presentations for IMPA and makes joint taps sound highly doable. You'll also be reminded about those fabled “fried egg cells.”Resources:https://www.cliniciansbrief.com/article/anemia-thrombocytopenia-immune-disorder-dogshttps://www.apoquel.comContact:podcast@instinct.vetWhere To Find Us:Website: CliniciansBrief.com/PodcastsYouTube: Youtube.com/@clinicians_briefFacebook: Facebook.com/CliniciansBriefLinkedIn: LinkedIn.com/showcase/CliniciansBrief/Instagram: @Clinicians.BriefX: @CliniciansBriefThe Team:Alyssa Watson, DVM - HostAlexis Ussery - Producer & Multimedia Specialist
Suruchi Mazumdar's book addresses the complex relationship between India's evolving, emerging media landscape, the political and economic interests of diverse media actors, and movements opposing contentious issues such as market-based economic reforms and religious nationalism. In the mid-2000s, Singur and Nandigram, nondescript semi-urban and rural areas in the east Indian state of West Bengal, suddenly became the center of national and international media attention and debates on state-led neoliberal agenda. The point of controversy were local agitations provoked by the then state government's plans to acquire agricultural land for large scale corporate industrial projects. The movements by farmers to protect their agricultural land were described variously as challenges to neoliberal initiatives and widespread social tension that put a temporary brake to state-led market reforms. In traditional liberal narratives, the triumph of economic reforms was expected to replace value-based ideology with global economic principles, perceived as objective and neutral. But the forces of neoliberalism became strongly entrenched in India alongside religious nationalism. Such political economic developments paralleled with the simultaneous expansion of India's digital and traditional media sectors, consolidation of market forces, the co-option of both old and new media by powerful actors, and opportunities of mediated democratization and activism. While narratives of economic liberalization and global trends of commercialized journalism have been amply documented, this book addresses the tension between mainstream media's political and commercial logic, movements and citizen-led activisms questioning dominant development and religious nationalist agenda, and the possibilities of political diversity and democratic participation in the Indian city of Kolkata. By focusing on the hybridities, commonalities, differences, and complexities in Kolkata's mainstream news media and emerging digital space, this book captures the regional and linguistic variations in the studies of media, movements, and politics in India. Dr Suruchi Mazumdar is an Associate Professor at Jindal School of Journalism and Communication, O.P. Jindal Global University in India. Dr Priyam Sinha is an Alexander Von Postdoctoral Research Fellow at the Institute for Asian and African Studies, Humboldt University in Berlin. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/communications
Suruchi Mazumdar's book addresses the complex relationship between India's evolving, emerging media landscape, the political and economic interests of diverse media actors, and movements opposing contentious issues such as market-based economic reforms and religious nationalism. In the mid-2000s, Singur and Nandigram, nondescript semi-urban and rural areas in the east Indian state of West Bengal, suddenly became the center of national and international media attention and debates on state-led neoliberal agenda. The point of controversy were local agitations provoked by the then state government's plans to acquire agricultural land for large scale corporate industrial projects. The movements by farmers to protect their agricultural land were described variously as challenges to neoliberal initiatives and widespread social tension that put a temporary brake to state-led market reforms. In traditional liberal narratives, the triumph of economic reforms was expected to replace value-based ideology with global economic principles, perceived as objective and neutral. But the forces of neoliberalism became strongly entrenched in India alongside religious nationalism. Such political economic developments paralleled with the simultaneous expansion of India's digital and traditional media sectors, consolidation of market forces, the co-option of both old and new media by powerful actors, and opportunities of mediated democratization and activism. While narratives of economic liberalization and global trends of commercialized journalism have been amply documented, this book addresses the tension between mainstream media's political and commercial logic, movements and citizen-led activisms questioning dominant development and religious nationalist agenda, and the possibilities of political diversity and democratic participation in the Indian city of Kolkata. By focusing on the hybridities, commonalities, differences, and complexities in Kolkata's mainstream news media and emerging digital space, this book captures the regional and linguistic variations in the studies of media, movements, and politics in India. Dr Suruchi Mazumdar is an Associate Professor at Jindal School of Journalism and Communication, O.P. Jindal Global University in India. Dr Priyam Sinha is an Alexander Von Postdoctoral Research Fellow at the Institute for Asian and African Studies, Humboldt University in Berlin. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
Suruchi Mazumdar's book addresses the complex relationship between India's evolving, emerging media landscape, the political and economic interests of diverse media actors, and movements opposing contentious issues such as market-based economic reforms and religious nationalism. In the mid-2000s, Singur and Nandigram, nondescript semi-urban and rural areas in the east Indian state of West Bengal, suddenly became the center of national and international media attention and debates on state-led neoliberal agenda. The point of controversy were local agitations provoked by the then state government's plans to acquire agricultural land for large scale corporate industrial projects. The movements by farmers to protect their agricultural land were described variously as challenges to neoliberal initiatives and widespread social tension that put a temporary brake to state-led market reforms. In traditional liberal narratives, the triumph of economic reforms was expected to replace value-based ideology with global economic principles, perceived as objective and neutral. But the forces of neoliberalism became strongly entrenched in India alongside religious nationalism. Such political economic developments paralleled with the simultaneous expansion of India's digital and traditional media sectors, consolidation of market forces, the co-option of both old and new media by powerful actors, and opportunities of mediated democratization and activism. While narratives of economic liberalization and global trends of commercialized journalism have been amply documented, this book addresses the tension between mainstream media's political and commercial logic, movements and citizen-led activisms questioning dominant development and religious nationalist agenda, and the possibilities of political diversity and democratic participation in the Indian city of Kolkata. By focusing on the hybridities, commonalities, differences, and complexities in Kolkata's mainstream news media and emerging digital space, this book captures the regional and linguistic variations in the studies of media, movements, and politics in India. Dr Suruchi Mazumdar is an Associate Professor at Jindal School of Journalism and Communication, O.P. Jindal Global University in India. Dr Priyam Sinha is an Alexander Von Postdoctoral Research Fellow at the Institute for Asian and African Studies, Humboldt University in Berlin. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/political-science
Suruchi Mazumdar's book addresses the complex relationship between India's evolving, emerging media landscape, the political and economic interests of diverse media actors, and movements opposing contentious issues such as market-based economic reforms and religious nationalism. In the mid-2000s, Singur and Nandigram, nondescript semi-urban and rural areas in the east Indian state of West Bengal, suddenly became the center of national and international media attention and debates on state-led neoliberal agenda. The point of controversy were local agitations provoked by the then state government's plans to acquire agricultural land for large scale corporate industrial projects. The movements by farmers to protect their agricultural land were described variously as challenges to neoliberal initiatives and widespread social tension that put a temporary brake to state-led market reforms. In traditional liberal narratives, the triumph of economic reforms was expected to replace value-based ideology with global economic principles, perceived as objective and neutral. But the forces of neoliberalism became strongly entrenched in India alongside religious nationalism. Such political economic developments paralleled with the simultaneous expansion of India's digital and traditional media sectors, consolidation of market forces, the co-option of both old and new media by powerful actors, and opportunities of mediated democratization and activism. While narratives of economic liberalization and global trends of commercialized journalism have been amply documented, this book addresses the tension between mainstream media's political and commercial logic, movements and citizen-led activisms questioning dominant development and religious nationalist agenda, and the possibilities of political diversity and democratic participation in the Indian city of Kolkata. By focusing on the hybridities, commonalities, differences, and complexities in Kolkata's mainstream news media and emerging digital space, this book captures the regional and linguistic variations in the studies of media, movements, and politics in India. Dr Suruchi Mazumdar is an Associate Professor at Jindal School of Journalism and Communication, O.P. Jindal Global University in India. Dr Priyam Sinha is an Alexander Von Postdoctoral Research Fellow at the Institute for Asian and African Studies, Humboldt University in Berlin. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/south-asian-studies
Suruchi Mazumdar's book addresses the complex relationship between India's evolving, emerging media landscape, the political and economic interests of diverse media actors, and movements opposing contentious issues such as market-based economic reforms and religious nationalism. In the mid-2000s, Singur and Nandigram, nondescript semi-urban and rural areas in the east Indian state of West Bengal, suddenly became the center of national and international media attention and debates on state-led neoliberal agenda. The point of controversy were local agitations provoked by the then state government's plans to acquire agricultural land for large scale corporate industrial projects. The movements by farmers to protect their agricultural land were described variously as challenges to neoliberal initiatives and widespread social tension that put a temporary brake to state-led market reforms. In traditional liberal narratives, the triumph of economic reforms was expected to replace value-based ideology with global economic principles, perceived as objective and neutral. But the forces of neoliberalism became strongly entrenched in India alongside religious nationalism. Such political economic developments paralleled with the simultaneous expansion of India's digital and traditional media sectors, consolidation of market forces, the co-option of both old and new media by powerful actors, and opportunities of mediated democratization and activism. While narratives of economic liberalization and global trends of commercialized journalism have been amply documented, this book addresses the tension between mainstream media's political and commercial logic, movements and citizen-led activisms questioning dominant development and religious nationalist agenda, and the possibilities of political diversity and democratic participation in the Indian city of Kolkata. By focusing on the hybridities, commonalities, differences, and complexities in Kolkata's mainstream news media and emerging digital space, this book captures the regional and linguistic variations in the studies of media, movements, and politics in India. Dr Suruchi Mazumdar is an Associate Professor at Jindal School of Journalism and Communication, O.P. Jindal Global University in India. Dr Priyam Sinha is an Alexander Von Postdoctoral Research Fellow at the Institute for Asian and African Studies, Humboldt University in Berlin. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/journalism
ReferencesAnal Cell Pathol (Amst).2018; 2018: 787.1814J. Biol. Chem. 2018;293:2422-2437Current Opinion in Structural BiologyVolume 83, December 2023, 102707The Journal of Biological Chemistry 2016.291, 23756-23768Mann, Martinez, O'Neill. 1979 "Angels at My Gate" Manfred Mann EB.https://open.spotify.com/track/2A9wPXzu7uijsOhIpbAH6e?si=2226c50bc7ab4a45Tchaikovsky, PI . 1880. Capricio Italiane" Romeo and Juliet; Nutcracker. https://open.spotify.com/album/0t5AVxOQO5GqqlZW0AeL0c?si=Fwd2uqTtQpqlzhILsRWXQA
ReferencesActa Pharm Sin B. 2019 Sep 3;10(3):414–433Mechanisms of Ageing and Development2016. Volume 156, Pages 25-33The Journal of Biological Chemistry 2018.293: 2422-2437.Anal Cell Pathol (Amst).2018; 2018: 787.1814.Mozart, WA. 1788. Divertimento 563 in E flat majorhttps://music.youtube.com/playlist?list=OLAK5uy_lDd2hLSAScEFRzcwXGJxrKjTTrPB9uDu0&si=xoAXTM_V9fYzT_cOTaylor and Baker 1968. "Passing the Time. Cream Wheels of Fire lphttps://music.youtube.com/playlist?list=OLAK5uy_lDd2hLSAScEFRzcwXGJxrKjTTrPB9uDu0&si=xoAXTM_V9fYzT_cOMeade, N. . 1964. "Time is On My Side." Rolling Stoneshttps://music.youtube.com/watch?v=7jStGLgQkSw&si=ufgxy8kPLG6djqWNCroce, J. 1974. "Time in a Bottle"https://music.youtube.com/watch?v=9h1davKgBYM&si=LEy6JDkroVjcT-lU
ReferencesCellular Signaling 2018 .Volume 46, June :129-134Free Radic Biol Med. 2021 Jul; 170: 59–69. J Vis Exp. 2020 Oct 27:(164)Acta Pharmaceutica Sinica B 2023. Volume 13, Issue 10, October :4089-4104Bruford/Squire/Anderson. 1972. "Heart of the Sunrise" Live Yessongs.https://music.youtube.com/watch?v=Ar_ObQIssRM&si=fE6vosqHz-DA9O17Lennon/McCartney. 1968. "Hello Goodbye" Magical Mystery Tour. Beatleshttps://music.youtube.com/watch?v=ywZqBGHDTlA&si=bBc_qmYfM_VFaVFn
New therapies for myositis and Sjögren disease: are you up to date? Credit available for this activity expires: 7/15/26 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002691?ecd=bdc_podcast_libsyn_mscpedu
ReferencesFront Immunol. 2017 Jun 9;8:643Acta Pharm Sin B. 2019 Sep 3;10(3):414–433Zappa, F. 1968 "Flower Punk" Mother's of Invention .We are only in it for the Money lp https://music.youtube.com/watch?v=HQfZmMI87P4&si=UyDyEQtzmAivWcMeZappa, F. 1976. "Black Napkins" on Zoot allures lp.https://music.youtube.com/watch?v=RfHT-T6R6WY&si=79BxfAu-YWlrg9wcCouperin, F. 1716. Pieces d' Clavecin. Livre 2. Order 6. les Bergerieshttps://music.youtube.com/watch?v=wOQRIoXptPo&si=D9SawR9a-cMB2qYt
ReferencesFront Immunol. 2017 Jun 9;8:643JAMA. 2021;325(16):1640-1649Journal of Hepatology 2012 56, 704-713DOI:(10.1016/j.Annual Review of Food Science and Technology.2022. Volume 13:263-286Annual Review of Pathological Mechanisms of Disease 2010. 5:99-118.Nature.2013 Jul 4;499(7456):97-101 Nature Reviews Gastroenterology and Hepatology 26 April 2019Cell Metabolism 2019. [29] 4:886-900Lamm, R. 1972. "While the City Sleeps" Chicago Vhttps://music.youtube.com/watch?v=qCrgrGsBlr0&si=oGMvJDfCrd2BU7_ICetera and Seraphine . "Lowdown" Chicago IIIhttps://music.youtube.com/watch?v=6LlZCBbeZTk&si=DrSyAp9lCzhZyqfWLamm, R. 1969. "Questions 67 and 68" CTAhttps://music.youtube.com/watch?v=0TKaFqhmmg4&si=_W-MMatKBBQ0cBF9
ReferencesThe Journal of Nutritional Biochemistry 2016.Volume 34, pages 1-7Immunologic Research,2020. 1559-0755,Feb, Vol. 68, Issue 1Cell Metabolism 2019. [29] 4:886-900Guerra, DJ.2025. Unpublished LecturesAnderson and Howe. 1971. "Roundabout" Yes.https://music.youtube.com/watch?v=pk3HBb0mh5Q&si=dO7xDgnAVqNl8Yv6Davis, T. 1971 "Your Saving Grace" Steve Miller Bandhttps://music.youtube.com/watch?v=RBJ6teB2IXw&si=etBGUDK87GprtnlrLennon/McCartney 1967. "She's Leaving Home" Beatles SPLHCB.https://music.youtube.com/watch?v=VaBPY78D88g&si=9upPJq5KC_jBDQI0Lennon/McCartney. 1966. "She Said" Revolver, lp Beatleshttps://music.youtube.com/watch?v=rLzfo59AdEc&si=r-AiTLLNsphoME0y
Understanding IgE-mediated food allergies Common presentations and management of IgE-mediated food allergies Impact of anaphylaxis on quality of life Referral to specialists and the importance of timely intervention Resources and support for healthcare professionals and patients Host: Dr David Lim | Total Time: 35 mins Expert: Dr Wendy Freeman, General Practitioner and Health Educator Register for our fortnightly FREE WEBCASTSEvery second Tuesday | 7:00pm-9:00pm AEST Click here to register for the next oneSee omnystudio.com/listener for privacy information.
REFERENCESFront Immunol.2019; 10: 1064.ASN Neuro. 2024 Nov 5;16(1):2404367.Int J Mol Sci. 2024 Apr 10;25(8):4199Page/Jones/Plant 1969. "Since I've Been Loving You" LZ III lp.https://open.spotify.com/track/1SDiiE3v2z89VxC3aVRKHQ?si=530d2dcc304f4199Lennon/McCartney, 1964. "I Don't Want to Spoil the Party"https://open.spotify.com/track/3kQDIa85ZK8cKVn72NfBnl?si=be68c3abca6341d8Lennon/McCartney 1967. "A Day in the Life" Sgt Pepper's LHCB. lp.https://open.spotify.com/track/0hKRSZhUGEhKU6aNSPBACZ?si=8589b727398f4fbbBiber, H.I.F. 1676. "Passacaglia in G Minor. Violin sonatahttps://open.spotify.com/track/2PvqhaYNHP4zHQynKeook4?si=479490bfb34c4c2d
ReferencesMol Cancer Ther. 2018 Jan; 17(1): 50–59 J Neuroinflammation. 2019; 16: 236. Cell Host Microbe. 2016 Feb 10; 19(2): 181–193Nat Rev Microbiol. 2009 Feb; 7(2): 99–109.Cells.2020 Feb 5;9(2).Biochimica et Biophysica Acta (BBA) - Biomembranes. 2016.Volume 1858, Issue 11, November Pages 2681-2688Nat Immunol. 2024 Apr 8;25(5):778–789. Dylan, B. 1975. "Tangled up in Blue"https://music.youtube.com/playlist?list=OLAK5uy_nHWCTvQI-G4uNRNvC0AjQr9hVXG54TeSU&si=xOVhlpdBm_ygXirlMcQuinn 1971. "Pale Blue" Byrdmaniax l phttps://youtu.be/Mh3J7GqrdzY?si=UtahiK75LoZhQLe7Baker, G. 1967. "Blue Condition" Cream Disraeli Gears lp.https://youtu.be/bOAkjNX1FDI?si=3q_FcsfvWTH95RyK
ReferencesCell Metabolism 2024. volume 36, Issue 4, 2 April : 839-856.e8Winwood/Davis. 1966 "Giimme Some Lovin" Spencer Davis Group.https://music.youtube.com/watch?v=BuQ3PaFyb9A&si=yAERzThIMPra_Ct1Cochran and Capehart. 1958. "Summertime Blues" The Who Live at Leeds lp.https://music.youtube.com/watch?v=ovHs-psC9F4&si=zLwITLtjW0aCwKPAVivaldi, A 1717-1718. "Summer" Violin Concerto. Marie Samuelson. No. 2 in G minor, Op. 8, RV 315,https://music.youtube.com/watch?v=g65oWFMSoK0&si=jw6PDRYCagn-B4fC
In this episode, host Alyssa Watson, DVM, is joined by John M. Thomason, DVM, MS, DACVIM (SAIM), to talk about his recent Clinician's Brief article, “Top 4 Primary Immune-Mediated Disorders in Dogs.” In part 1 of this 2-part conversation, Dr. Thomason focuses on the diagnosis and management of IMHA and IMTP. You'll hear vital details for both conditions including the right way to handle blood smears and slide agglutination, which IMHA cases are hypercoagulable (spoiler: all of them), and if vincristine actually helps in IMTP (spoiler again: it does).Resources:https://www.cliniciansbrief.com/article/anemia-thrombocytopenia-immune-disorder-dogshttps://www.zoetisus.com/products/dogs/librelaContact:podcast@instinct.vetWhere To Find Us:Website: CliniciansBrief.com/PodcastsYouTube: Youtube.com/@clinicians_briefFacebook: Facebook.com/CliniciansBriefLinkedIn: LinkedIn.com/showcase/CliniciansBrief/Instagram: @Clinicians.BriefX: @CliniciansBriefThe Team:Alyssa Watson, DVM - HostAlexis Ussery - Producer & Multimedia Specialist
ReferencesGuerra. DJ. 2025. Unpublished LecturesFront. Immunol.,2024. 22 February Sec. Multiple Sclerosis and Neuroimmunology Volume 15 .Annals of Clinical & Laboratory Science.2022.vol. 52, no. 5 pp763-771.Mol Biosyst. 2014 Oct;10(10):2505-8. Frey/Henley. 1973. "Desperado" The Eagleshttps://music.youtube.com/playlist?list=OLAK5uy_k3UBMdBe0k-PWX6y1VCLJZVJogoUaKEco&si=9kkmSQG5xcdpbINRWelch, B 1973. "Emerald Eyes" Fleetwood Mac.Mystery to Me lp.https://music.youtube.com/watch?v=DnQM535xV-U&si=sRsNuXaEJ1A4VWPJ
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PBS News is supported by - https://www.pbs.org/newshour/about/funders
TWiV reviews cuts in National Science Foundation budgets, cuts to Harvard University grants, judge blocks ban on Harvard enrolling international students, DOGE ordered cuts of NIH grants, endemic coronavirus infection induces Fc receptor binding antibodies to SARS-CoV-2, and inherited IFNAR1 deficiency causing adverse reactions to measles and yellow fever infectious vaccines. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV NSF funding cut to lowest level (NY Times) 1,000 grants cut at Harvard University (Nature) Administration ban on international students at Harvard blocked (CNN) DOGE killed NIH grants (Nature) Endemic coronavirus infection induces FcR binding antibodies to SARS-CoV-2 (J Virol) IFNAR1 deficiency and severe reaction to measles and yellow fever vaccines (J Exp Med) Letters read on TWiV 1221 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Contact lenses that give people infrared vision — even with their eyes shut (one, two) Alan – Autocrats are afraid of you – see the graphic, especially. Vincent – How One Company Secretly Poisoned The Planet Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
India and Pakistan have agreed to a ceasefire. AP correspondent Donna Warder reports.
Many of you, you have passed the late contractions phase, you're about to deliver any day now. This episode will serve as confirmation, clarity and a prophetic encouragement for those who are: — in transition…. From Singlehood to MarriageFrom Pit to PalaceFrom Last to FirstFrom barren to fruitful From almost there, arrive From process and preparation to fulfillment and destiny. May will be like the wind! It just started but it's already on the way out. It's a month of contending and divine rehearsal! We must be prudent, alert and strategic all-month because summer is at the door and fall is only a quarter away. This is not to make you anxious, it's to exhort your faith to believe God and Move with His Word and declare His promises, because they cannot return void. This is where acceleration and faith collide to bring Divine Fulfillment. 2025…. Is a divine rehearsal for the latter of this decade. It's time to remove the old and where the new! Mediated scriptures: Samuel 25:1-44, Genesis 41, Esther 4-5, Luke 6:38, Galatians 6:9. Suggested readings: the entire book of Esther, Genesis 40-50. Suggested archive episodes to listen to: “ Stillness, Calling, Divine Connections, Two Part episodes, “ Year of Double Grace: Mobility, Faith, Love,” “ Series: Dating & Marriage Prerequisites,” and “Your Name Has Been Called: It's Time to Remove the Old and Wear the New” This year we are praying more people would hear such messages, to be stirred to read God's word to live the life He always destined them to live, including having the right spouse and marriage He desired for them to have. If you enjoyed our series, “ Dating & Marriage Prerequisites., you don't want to miss our live session this year, “ Kingdom Relationships 2.0.” We'd love to meet you and exhort you in person. Subscribe to our site for updates!
From the BBC World Service: The Yemeni group started attacking shipping lanes around the Red Sea after the war in Gaza began. It's hoped the ceasefire will stop disruptions to major trade routes. Then, China and the U.S. are set to hold their first trade talks since sweeping tariffs were announced. Later: Spanish Prime Minister Pedro Sánchez on last week's massive power outage and former U.S. President Joe Biden on defense and international trade.
From the BBC World Service: The Yemeni group started attacking shipping lanes around the Red Sea after the war in Gaza began. It's hoped the ceasefire will stop disruptions to major trade routes. Then, China and the U.S. are set to hold their first trade talks since sweeping tariffs were announced. Later: Spanish Prime Minister Pedro Sánchez on last week's massive power outage and former U.S. President Joe Biden on defense and international trade.
1. IDF Airstrikes Disable Sanaa International Airport. Dozens of Israeli Air Force aircraft were involved in the strikes on Yemen on Tuesday, including fighter jets, refuelers, and spy planes. The IDF said the fighter jets dropped 50 munitions on the targets.2. President Trump Announces Truce with Houthis; Halts Bombing in Yemen. Oman revealed that it had mediated the ceasefire deal under which neither side will target the other, including US vessels in the Red Sea and Bab al-Mandab Strait.3. A fourth round of nuclear talks between Iran and the United States is likely to take place over the weekend in the capital of Oman, with Iranian state media pointing to May 11 as a probable date.4. Mediated by United Arab Emirates, Russia & Ukraine Exchange 205 Prisoners of War. This marks the fifth known prisoner of war swap of 2025.5. Ukraine dismisses idea of attacking the Russian Victory Day Parade in Moscow on 9 May.6. US Army tests 2 x counter UAS systems in Philippines- the Integrated Fires Protection Capability–High-Powered Microwave (IFPC-HPM) and the Fixed Site–Low, Slow, Small Unmanned Aerial System Integrated Defeat System (FS-LIDS).7. USAF Sentinel ICBM Program Update. The Sentinel program will procure up to 634 missiles, with an additional 25 for development and testing — and deploy 400 of them in silos spread across missile fields in the US Great Plains. 8. USMC Landing Ship, Medium update.
In this month's episode of the HAE Speaks Podcast, please join Raffi Tachdjian, MD, MPH, Associate Clinical Professor, David Geffen School of Medicine at UCLA, and Kenny Robinson, MD, Head of Medical Affairs, North America at Pharvaris, for a discussion about the full spectrum of a bradykinin-mediated angioedema attack. This podcast episode highlights the experience of the physician and those living with bradykinin-mediated angioedema, explores the nuances of attack progression and resolution, and shares strategies to inform clinical assessment and improve outcomes for individuals with HAE.We would like to thank Pharvaris for sponsoring this episode of the HAE Speaks Podcast.
This AANEM podcast features Dr. Joome Suh, a neurologist and neuromuscular specialist at Brigham and Women's Hospital, interviewed by neuromuscular fellow Dr. Nadia Khalil. They discuss HMG-CoA reductase immune-mediated necrotizing myopathy (HMGCR IMNM), a rare autoimmune muscle disease often associated with statin use. The discussion covers clinical presentation, epidemiologic considerations, histopathologic findings, and treatment approaches, with special focus on Dr. Suh's recent research published in Muscle and Nerve with co-author Dr. Anthony Amato. Their study found that patients receiving maintenance IVIG as part of their regimen were more likely to have a normal CK at 6 months and the daily prednisone-equivalent was lower. A sub-group analysis suggested IVIG as monotherapy is effective.
In this episode, we review the high-yield topic of Humoral-Mediated Immunity from the Immunology section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
It Happened To Me: A Rare Disease and Medical Challenges Podcast
Jaime Albright Henighan shares her family's journey after two of her sons, Joshua and Jorden, were diagnosed with a rare genetic kidney disease called APOL1-mediated FSGS (Focal Segmental Glomerulosclerosis). Jaime's story highlights the importance of early detection, education, and advocacy for families navigating this challenging condition. She discusses her partnership with Nephcure, a patient advocacy organization, and her mission to raise awareness about FSGS, especially among individuals of West African descent, who are at higher risk due to the APOL1 gene mutation. Topics Covered: What is FSGS?: Understanding APOL1-mediated FSGS and its impact on kidney health. The Family's Journey: How high blood pressure led to Joshua's diagnosis, and the shock of discovering Jorden had the same condition. The Role of Genetics: Why individuals of West African descent are at greater risk and the importance of genetic awareness. Early Detection: How identifying symptoms early has helped Jaime's sons manage their health. Advocacy and Education: Jaime's work with Nephcure and her efforts to raise awareness globally, including in Ghana. Parenting Through Challenges: Jaime's emotional journey as a mother and her advice for other parents navigating rare diseases. Key Moments: Jaime explains how her family discovered FSGS and the challenges they faced in obtaining a diagnosis. Insights into the genetic factors behind APOL1-mediated FSGS and its prevalence in specific populations. Advocacy efforts to educate families and healthcare providers about the disease. Guest Bio: Jaime is a wife and mother of six. Her family resides in Alpharetta, GA. She is also a Forensic Interviewer and Podcast Producer at Tenderfoot TV. In 2021, her seemingly healthy 17 year old son, Joshua, was randomly diagnosed with high blood pressure. This led to additional testing and a diagnosis of Focal Segmental Glomerulosclerosis (FSGS), a rare genetic kidney disease. Later that year, her 25 year old son, Jorden, was also diagnosed with FSGS. This was shocking to the Albright Henighan family. How could they be at high risk of a disease that they had never heard of? They connected with Nephcure, a patient advocacy organization, for support and resources. They learned that 1 in 8 people of West African descent are at risk of APOL1 mediated FSGS due to a genetic mutation. Thanks to early detection, her sons are stable today but this is a rare outcome for FSGS patients due to a lack of education and barriers in the medical community. They decided to share their story across the United States and even in Ghana. Their goal is to educate and empower others. If caught early, there are medical interventions and clinical research trials that can save native kidneys and lives. There is hope for FSGS patients. Resources Mentioned: Nephcure Kidney International: Advocacy and support for families affected by kidney diseases. Information on APOL1-mediated FSGS and genetic testing. Tips for recognizing early symptoms of kidney disease. Connect with Us: Stay tuned for the next new episode of “It Happened To Me”! In the meantime, you can listen to our previous episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “It Happened To Me”. “It Happened To Me” is created and hosted by Cathy Gildenhorn and Beth Glassman. DNA Today's Kira Dineen is our executive producer and marketing lead. Amanda Andreoli is our associate producer. Ashlyn Enokian is our graphic designer. See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, ItHappenedToMePod.com. Questions/inquiries can be sent to ItHappenedToMePod@gmail.com.
God's Protective and Mediated Words
①Premier Li Qiang pledged expanded market access for foreign investors at the China Development Forum 2025. (00:42)②China and Japan have reached 20 consensus points in high-level economic dialogue. How significant are they for bilateral ties? (12:17)③Ukraine and Russia are holding talks separately with the United States in Saudi Arabia. What to expect? (24:34)④China's ambassador to the US has described weaponizing tariffs as a boomerang that would only backfire. (33:36)⑤South Korea's constitutional court has reinstated Han Duck-soo as the country's acting president. What will come next? (43:00)
Bret Weinstein speaks with Laura Delano, the author of “Unshrunk: A Story of Psychiatric Treatment Resistance” on the subject of today's mental health treatment and psychotropic medications.Find Laura Delano on X at https://x.com/LauraDelano and her book, “Unshrunk: A Story of Psychiatric Treatment Resistance” at https://unshrunkthebook.com.*****This episode is sponsored by:Jolie: For your best skin & hair guaranteed head to http://jolieskinco.com/DARKHORSE to try it out for yourself with FREE shipping.VanMan: Tallow and honey balm, deodorant, and many other amazing animal based personal care products.Go to http://www.vanmanscompany.com/darkhorse and use code darkhorse10 for 10% off your first order.*****Join DarkHorse on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com Check out the DHP store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://www.darkhorsestore.orgTheme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.*****Mentioned in this episode:- The Challenge of Going Off Psychiatric Drugs https://www.newyorker.com/magazine/2019/04/08/the-challenge-of-going-off-psychiatric-drugs- A Hunter-Gatherer's Guide to the 21st Century https://amzn.to/3AGANGg (commission earned)Support the show
Rebuke worry if it tries to pay you a visit in this season. It doesn't look like what it looks like. You're not in the old, you're in the new. God has established many of His people in a phase of life they've never experienced before. Things have shifted for you, forever. God can see what we can't and although there are things you want to see now and do now, the land isn't fully dry. But I have good news for you! God is signaling you're about to leave the ark. It won't be long until you experience fruitfulness and His divine multiplication in your life. God never heals and transforms His people and then not allow them to fulfill their destiny and receive what He promised them. Relax… God has not forgotten about you, He's just gone ahead of you to prepare the way. Press play to hear more! Mediated scriptures Genesis 6-9. This year we are praying more people would hear such messages, to be stirred to read God's word to live the life He always destined them to live, including having the right spouse and marriage He desired for them to have. If you enjoy this series, you don't want to miss our live session this year, “ Kingdom Relationships 2.0.” We'd love to meet you and exhort you in person. Subscribe to our site for updates!
LATE BREAKING CLINICAL SCIENCE: CT-Guided Ozone-Mediated Renal Denervation Treating Resistant Hypertension
Welcome to this podcast where we dive into the intersection of cutting-edge science and practical healthcare, exploring the questions that shape patient outcomes and redefine how we approach complex diseases. Today we're talking about a topic that's critical for nephrologists and all healthcare professionals working with kidney disease, APOL1-mediated kidney disease, or AMKD.Let us know what you thought of this week's episode on Twitter: @physicianswkly Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com! Thanks for listening!
Joe kicks off this week's show by sharing aspects of his "rough week" with the audience. Once he's done venting, he begins his training talk :) During the 1st half of the show he shares an online interaction he recently had with an ignorant "science-based" lifter... This discussion is centered around "stretch mediated hypertrophy" and Joe's biggest pet peeve with the current "lengthened training" obsession. The 2nd half of the show is dedicated to balance training. Joe reveals the SECRET to improving balance in the "real world" as well as the most overrated balance training techniques! *For a full list of Show Notes + Timestamps visit www.IndustrialStrengthShow.com. IMPORTANT LINKS Team Forever Strong [1-Week Free Trial] CPPS certification [code: JOED30] Joe's Instagram
Joe kicks off this week's show by sharing aspects of his "rough week" with the audience. Once he's done venting, he begins his training talk :) During the 1st half of the show he shares an online interaction he recently had with an ignorant "science-based" lifter... This discussion is centered around "stretch mediated hypertrophy" and Joe's biggest pet peeve with the current "lengthened training" obsession. The 2nd half of the show is dedicated to balance training. Joe reveals the SECRET to improving balance in the "real world" as well as the most overrated balance training techniques! *For a full list of Show Notes + Timestamps visit www.IndustrialStrengthShow.com. IMPORTANT LINKS Team Forever Strong [1-Week Free Trial] CPPS certification [code: JOED30] Joe's Instagram
Word of encouragement as we wrap this season to enter spring 2025 very soon. I don't know about you but the shift has already occurred. Spring is in full swing. The Lord wants us to use the end of February, to prepare mentally and spiritually for spring and summer 2025. As we shared in our two part episode, Year of Double Grace:Mobility, Faith & Love. I am sensing by God's grace, much emphasis will be on “mobility and faith” regarding this spring 2025. The Lord has been showing up already in special ways concerning all three. But in particular, I do believe “mobility and faith” will take the forefront for many of us. As you might have already notice, the momentum is building and the time is accelerating and God is wanting us all to catch up and not delay any longer. The Lord is waning us to trust Him and be mobile- be in motion while carrying the vision, words and His promises. To hear more press play! Mediated scriptures: Jeremiah 17:7, Isaiah 62:6-7, Psalm 90:12. Suggested archive series & episodes to listen to: Way to the Promise series, & Parts 1 & 2, Year of Double: Mobility, Faith & Love. As mentioned on tonight's episode, I highly recommend you to follow @manjekibon on Instagram if you love Haitian & Caribbean food. I always say this, I'm not trying to be biased, but you have never had good Haitian food, until you have Manji Ki Bon. This year we are praying more people would hear such messages, to be stirred to read God's word to live the life He always destined them to live, including having the right spouse and marriage He desired for them to have. If you enjoy this series, you don't want to miss our live session this year, “ Kingdom Relationships 2.0.” We'd love to meet you and exhort you in person. Subscribe to our site for updates!
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