Podcasts about Mediated

Rebuke worry if it tries to pay you a visit in this season. It doesn't look like what it looks like. You're not in the old, you're in the new. God has established many of His people in a phase of life they've never experienced before. Things have shifted for you, forever. God can see what we can't and although there are things you want to see now and do now, the land isn't fully dry. But I have good news for you! God is signaling you're about to leave the ark. It won't be long until you experience fruitfulness and His divine multiplication in your life. God never heals and transforms His people and then not allow them to fulfill their destiny and receive what He promised them. Relax… God has not forgotten about you, He's just gone ahead of you to prepare the way. Press play to hear more! Mediated scriptures Genesis 6-9. This year we are praying more people would hear such messages, to be stirred to read God's word to live the life He always destined them to live, including having the right spouse and marriage He desired for them to have. If you enjoy this series, you don't want to miss our live session this year, “ Kingdom Relationships 2.0.” We'd love to meet you and exhort you in person. Subscribe to our site for updates!

Joe kicks off this week's show by sharing aspects of his "rough week" with the audience. Once he's done venting, he begins his training talk :) During the 1st half of the show he shares an online interaction he recently had with an ignorant "science-based" lifter... This discussion is centered around "stretch mediated hypertrophy" and Joe's biggest pet peeve with the current "lengthened training" obsession. The 2nd half of the show is dedicated to balance training. Joe reveals the SECRET to improving balance in the "real world" as well as the most overrated balance training techniques! *For a full list of Show Notes + Timestamps visit www.IndustrialStrengthShow.com. IMPORTANT LINKS Team Forever Strong [1-Week Free Trial] CPPS certification [code: JOED30] Joe's Instagram  

Joe kicks off this week's show by sharing aspects of his "rough week" with the audience. Once he's done venting, he begins his training talk :) During the 1st half of the show he shares an online interaction he recently had with an ignorant "science-based" lifter... This discussion is centered around "stretch mediated hypertrophy" and Joe's biggest pet peeve with the current "lengthened training" obsession. The 2nd half of the show is dedicated to balance training. Joe reveals the SECRET to improving balance in the "real world" as well as the most overrated balance training techniques! *For a full list of Show Notes + Timestamps visit www.IndustrialStrengthShow.com. IMPORTANT LINKS Team Forever Strong [1-Week Free Trial] CPPS certification [code: JOED30] Joe's Instagram  

Word of encouragement as we wrap this season to enter spring 2025 very soon. I don't know about you but the shift has already occurred. Spring is in full swing. The Lord wants us to use the end of February, to prepare mentally and spiritually for spring and summer 2025. As we shared in our two part episode, Year of Double Grace:Mobility, Faith & Love. I am sensing by God's grace, much emphasis will be on “mobility and faith” regarding this spring 2025. The Lord has been showing up already in special ways concerning all three. But in particular, I do believe “mobility and faith” will take the forefront for many of us. As you might have already notice, the momentum is building and the time is accelerating and God is wanting us all to catch up and not delay any longer. The Lord is waning us to trust Him and be mobile- be in motion while carrying the vision, words and His promises. To hear more press play! Mediated scriptures: Jeremiah 17:7, Isaiah 62:6-7, Psalm 90:12. Suggested archive series & episodes to listen to: Way to the Promise series, & Parts 1 & 2, Year of Double: Mobility, Faith & Love. As mentioned on tonight's episode, I highly recommend you to follow @manjekibon on Instagram if you love Haitian & Caribbean food. I always say this, I'm not trying to be biased, but you have never had good Haitian food, until you have Manji Ki Bon. This year we are praying more people would hear such messages, to be stirred to read God's word to live the life He always destined them to live, including having the right spouse and marriage He desired for them to have. If you enjoy this series, you don't want to miss our live session this year, “ Kingdom Relationships 2.0.” We'd love to meet you and exhort you in person. Subscribe to our site for updates!

The Ceasefire came into effect on January 19th, 2025. Mediated by the US, Egypt and Qatar, it is a temporary and fragile peace which shows signs of fraying at the edges. The Trump Administration will be scrutinizing the terms with a view to re-negotiating an agreement more favorable to Israel and the US.

12 (nuggets) Lessons from God in 2024… press play to hear them and be blessed! Closing remarks and encouragement as we turn the page from 2024 to step into 2025:God is not surprised by how your life is going right now. He knows the end of your story and it's good, as long as you remain surrendered to Him. When life is good and when life is hard. I have never seen God put me to shame; I know He won't put you to shame, either. Enter 2025 with God and leave whatever is not of Him or in His will, behind. His will is for you to live for His glory. His will is for you to prosper and be at peace. His will is to rejoice in the Lord and thank Him in every circumstance. His will is to occupy and dwell in His goodness and faithfulness until you behold Him in His glory. Mediated scriptures: Ecclesiastes 3, Psalm 90:12-17, Isaiah 46:4, Jon 11:16, Genesis 41:51, 2 Samuel 7:25, 1 Peter 5:10, Philippians 1:16. We'd love to gather with our listeners in person next year but seating is limited. We want to exclusively invite those of you who want to join us In-person next year, for our next session. To stay updated for all future announcements regarding our next session, Kingdom Relationships 2.0, subscribe to our website

References Guerra, DJ. December 2024.Biochemistry Notes Simon, P. 1965. "I Am a Rock" https://open.spotify.com/track/0byOqNZN9ailhoORv5Ps0Z?si=06bbef80ecd3422c Hendrix, J. 1967. "The Wind Cries Mary". https://open.spotify.com/track/5H6Jp0syB5yEPk7SWYdlmk?si=8e1c5a8937eb4f61 Hunter-Garcia. 1970. "Broke Down Palace" https://open.spotify.com/track/362CS15hE1upuTKoWApzLn?si=58805cf8707849cf Biber, 1676. Mystery Sonatas. Rosencrantz Sonata. https://open.spotify.com/album/5SWHQSd9xUlzt62OyxM0zs?si=ils6kNQBQveKNlppbQD15Q --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Eur. J. Immunol.,2018. 48: 1944-1957. FASEB J. 2019 Aug;33(8):9656-9671. The Byrds. 1967. Monterey Pops Festival. Live https://youtu.be/9-EdPDptH_c?si=9MBQTDISSXQZeXjQ Rossini.G. 1813 L'Italiana in Algeri .Overtur. https://youtu.be/ECoJcfsGibE?si=WKm8aRmO_97SWBOS --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References J Lipid Res. 2016 Feb;57(2):159–175. Cancer Gene Ther. 2023 Jan;30(1):172-181 King and Goffin.1968." Goin' Back" Byrds on The Notorious Byrd Brothers. lp https://open.spotify.com/track/6mM3QPK502fHwOYaj6ELmm?si=52616d4a3fe94c85 Argent, R. 1964. "She's Not There". Zombies https://open.spotify.com/track/6s6jmTumtDJGOB725jMJ8z?si=48a739d31d124ed4 Mozart, WA. 1787. Serenade #13. in G Major K.525 Allegro https://open.spotify.com/track/2RVIqa13miPikrqt6P7u4l?si=f0372e331d0c4647 Andante https://open.spotify.com/track/4MPpLp55Tpmk4woKC8A5VO?si=24030dcf18084dbb --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Community members in South Omaha planned to meet with police last night, but many weren't permitted to enter the room.

Community members in South Omaha planned to meet with police last night, but many weren't permitted to enter the room.

RECOVERING POLITICIANS: CANADA POST STRIKE REACHES DAY 26 Guest Host Jane Brown was joined by Cheri DiNovo, former NDP MPP, George Smitherman, former Ontario Liberal Cabinet Minister and Lisa Raitt, former Federal Conservative Deputy Leader. Mediated talks to end the Canada Post strike remain stalled, with no updates on resumption. The union's latest proposal includes a 19% wage increase over four years, down from 24%, and a guaranteed 20-hour minimum for part-time workers. Canada Post's wage offer stands at 11.5%, with no word on further changes. The government has yet to intervene. REPORT: GTHA TRAFFIC GRIDLOCK COSTS $44.7B IN LOST PRODUCTIVITY ANNUALLY Jane is joined by Nadia Todorova, executive director of the Residential and Civil Construction Alliance of Ontario and Teresa Di Felice, Assistant Vice President, Government and Community Relations for CAA South Central Ontario. Traffic congestion in the Greater Toronto and Hamilton Areas costs $10 billion in lost opportunities this year alone, rising to $47 billion when factoring in social impacts. A new report reveals vehicle numbers in the region have grown 37% since 2001. DOUG FORD'S ENCAMPMENT PLAN SPARKS DIVISION, SURVEY SHOWS Jane was joined by Eddie Sheppard, Vice President, Insights at Abacus Data. An Abacus survey shows Ontarians are divided on Premier Doug Ford's approach to encampments, with just 12% supporting stronger law enforcement. Many favor affordable housing (34%) or increased mental health services (14%). Meanwhile, 65% express concern about encampments in their communities.

References Nature 2024.volume 635, pages 1010–1018 Trad. 1923. "Midnight Special" CCR https://open.spotify.com/track/5jRQvcl66ovRTjUwzXziZA?si=b15d07dc2d1448db Hunter-Garcia 1979 "Althea" Grateful Dead https://open.spotify.com/track/7M7AwtGvWdMYudqx5Iuh1m?si=bd3d661d47d14992 Mozart, WA. 1779. Sinfonia Concertante K364. https://youtu.be/_0hTDZ0whpU?si=K3PDAEJUz08t6i-L Bruce, Jack 1968. "Train Time" Live. Wheels of Fire lp. Cream https://open.spotify.com/track/7cJgHvkMpSkZDw9aYWYTWm?si=eff3eaa37fb8440d --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Nature 2024.volume 635, pages 1010–1018 Front. Immunol. 2024. Sec. Multiple Sclerosis and Neuroimmunology Volume 15. J Immunol 2017. 199 (3) 874-884. Hunter-Garcia.1970 "Cumberland Blues" on Workingman's Dead https://open.spotify.com/track/2op5szd2IY8bOPzumqmFY3?si=8e3061b4559a4a31 Mozart. WA. 1791. Clarinet Concerto in A K 622 https://open.spotify.com/album/5WZELp7jlJNdS2xgLRknwe?si=ROhHJdu2RWCIpqnL7KXFUg --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Nature Communications 2023.volume 14. Article number: 794 Guerra, DJ.2024 Lecture notes Mozart, WA. 1781. Serenade in B Flat " Gran Partita" K.361 https://youtu.be/BbjpuMid8DE?si=52qNaebE0gZcVK-h --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

REFERENCES Guerra, DJ. 2024. Lectures. Sidran, B.1970."Steve Miller's Midnight Tango" https://open.spotify.com/track/2RrpVlFjLyHb6xLjUqooOp?si=a0802956638b467b --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Biochimica et Biophysica Acta 2000.1486:312-332 Guerra, DJ. 2024. Lectures Haydn, MJ. 1794 Masses (MH 551-553) https://open.spotify.com/album/67v4gHJdnVWAn4erEtbuIc?si=8z3w0ufGT9qjbyLjsAkfHA --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

The plant Cannabis sativa L. has historically served as a herbal remedy, garnering a considerable surge in both recreational and medicinal domains in contemporary times. However, this increased application has not aligned with our clinical awareness regarding the disturbances associated with cannabis. This assumes heightened significance in the context of palliative care for cancer patients, as the parameters controlling the interactions between cannabis and cancer have remained poorly defined. For upcoming interviews check out the Grad Chat webpage on Queen’s University School of Graduate Studies & Postdoctoral Affairs website.

0:00- Intro               1:00- Pak's background and strength               8:00- Bodybuilding versus other endeavors               10:30- New lengthened partials research               17:30- Stretch mediated hypertrophy vs lengthened partials               22:00- Lengthened partials               35:00- Advanced trainees and genetic elites               51:00- Stronger By Science               1:00:00- Appealing to the masses               1:04:00- Where to find Dr. Pak

We're taking a short break so we wanted to share this Best Of In the Demo podcast episode with you.This episode first aired August 31, 2024.The story about Millennials and dating is all about apps, sexting and ghosting - the habits of the toxically online. But it's not all toxic - it can help people discover how to be intimate and confident in their romantic relationships. Still, real concerns about privacy and security abound. We sat down with Katy Coduto, PhD, an assistant professor of media studies at Boston University and author of the forthcoming Technology, Privacy, and Sexting: Mediated Sex.Find out more about Katy here: https://kdcoduto.comCheck out these other episodes about sex and intimacy for Millennials & Gen Z: The Social Sex Revolution, with Cindy GallopIntimate Inequalities with Cristen DalessandroIn The Demo, a podcast about how stories of groups are created, subverted and destroyed. On the first season, we pursue the origins of the Millennial Myth. Farrah Bostic is the founder and Head of Research & Strategy of, The Difference Engine, a strategic insights consultancy focused on helping business leaders make decisions. Adam Pierno, author and brand consultant and managing director of brand strategy at Arizona State University. Our host is voiced by Eliza, a robot created by Murf.ai.In the Demo is edited by Allison Preisinger and AMP Studio. Music by 0megaMan under the Creative Commons license. Learn more and find research and supporting materials at inthedemopodcast.com Hosted on Acast. See acast.com/privacy for more information.

In her incisive study Baseball as Mediated Latinidad: Race, Masculinity, Nationalism, and Performances of Identity (Ohio State University Press, 2020), Jennifer Domino Rudolph analyzes major league baseball's Latin/o American players—who now make up more than twenty-five percent of MLB—as sites of undesirable surveillance due to the historical, political, and sociological weight placed on them via stereotypes around immigration, crime, masculinity, aggression, and violence. Rudolph examines the perception by media and fans of Latino baseball players and the consumption of these athletes as both social and political stand-ins for an entire culture, showing how these participants in the nationalist game of baseball exemplify tensions over race, nation, and language for some while simultaneously revealing baseball as a practice of latinidad, or pan-Latina/o/x identity, for others. By simultaneously exploring the ways in which Latino baseball players can appear both as threats to American values and the embodiment of the American Dream, and engaging with both archival research and new media representations of MLB players, Rudolph sheds new light on the current ambivalence of mainstream American media and fans towards Latin/o culture. David-James Gonzales (DJ) is Assistant Professor of History at Brigham Young University. He is a historian of migration, urbanization, and social movements in the U.S., and specializes in Latina/o/x politics and social movements. Follow him on Twitter @djgonzoPhD. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

In her incisive study Baseball as Mediated Latinidad: Race, Masculinity, Nationalism, and Performances of Identity (Ohio State University Press, 2020), Jennifer Domino Rudolph analyzes major league baseball's Latin/o American players—who now make up more than twenty-five percent of MLB—as sites of undesirable surveillance due to the historical, political, and sociological weight placed on them via stereotypes around immigration, crime, masculinity, aggression, and violence. Rudolph examines the perception by media and fans of Latino baseball players and the consumption of these athletes as both social and political stand-ins for an entire culture, showing how these participants in the nationalist game of baseball exemplify tensions over race, nation, and language for some while simultaneously revealing baseball as a practice of latinidad, or pan-Latina/o/x identity, for others. By simultaneously exploring the ways in which Latino baseball players can appear both as threats to American values and the embodiment of the American Dream, and engaging with both archival research and new media representations of MLB players, Rudolph sheds new light on the current ambivalence of mainstream American media and fans towards Latin/o culture. David-James Gonzales (DJ) is Assistant Professor of History at Brigham Young University. He is a historian of migration, urbanization, and social movements in the U.S., and specializes in Latina/o/x politics and social movements. Follow him on Twitter @djgonzoPhD. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/latin-american-studies

In her incisive study Baseball as Mediated Latinidad: Race, Masculinity, Nationalism, and Performances of Identity (Ohio State University Press, 2020), Jennifer Domino Rudolph analyzes major league baseball's Latin/o American players—who now make up more than twenty-five percent of MLB—as sites of undesirable surveillance due to the historical, political, and sociological weight placed on them via stereotypes around immigration, crime, masculinity, aggression, and violence. Rudolph examines the perception by media and fans of Latino baseball players and the consumption of these athletes as both social and political stand-ins for an entire culture, showing how these participants in the nationalist game of baseball exemplify tensions over race, nation, and language for some while simultaneously revealing baseball as a practice of latinidad, or pan-Latina/o/x identity, for others. By simultaneously exploring the ways in which Latino baseball players can appear both as threats to American values and the embodiment of the American Dream, and engaging with both archival research and new media representations of MLB players, Rudolph sheds new light on the current ambivalence of mainstream American media and fans towards Latin/o culture. David-James Gonzales (DJ) is Assistant Professor of History at Brigham Young University. He is a historian of migration, urbanization, and social movements in the U.S., and specializes in Latina/o/x politics and social movements. Follow him on Twitter @djgonzoPhD. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/gender-studies

In her incisive study Baseball as Mediated Latinidad: Race, Masculinity, Nationalism, and Performances of Identity (Ohio State University Press, 2020), Jennifer Domino Rudolph analyzes major league baseball's Latin/o American players—who now make up more than twenty-five percent of MLB—as sites of undesirable surveillance due to the historical, political, and sociological weight placed on them via stereotypes around immigration, crime, masculinity, aggression, and violence. Rudolph examines the perception by media and fans of Latino baseball players and the consumption of these athletes as both social and political stand-ins for an entire culture, showing how these participants in the nationalist game of baseball exemplify tensions over race, nation, and language for some while simultaneously revealing baseball as a practice of latinidad, or pan-Latina/o/x identity, for others. By simultaneously exploring the ways in which Latino baseball players can appear both as threats to American values and the embodiment of the American Dream, and engaging with both archival research and new media representations of MLB players, Rudolph sheds new light on the current ambivalence of mainstream American media and fans towards Latin/o culture. David-James Gonzales (DJ) is Assistant Professor of History at Brigham Young University. He is a historian of migration, urbanization, and social movements in the U.S., and specializes in Latina/o/x politics and social movements. Follow him on Twitter @djgonzoPhD. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/caribbean-studies

In her incisive study Baseball as Mediated Latinidad: Race, Masculinity, Nationalism, and Performances of Identity (Ohio State University Press, 2020), Jennifer Domino Rudolph analyzes major league baseball's Latin/o American players—who now make up more than twenty-five percent of MLB—as sites of undesirable surveillance due to the historical, political, and sociological weight placed on them via stereotypes around immigration, crime, masculinity, aggression, and violence. Rudolph examines the perception by media and fans of Latino baseball players and the consumption of these athletes as both social and political stand-ins for an entire culture, showing how these participants in the nationalist game of baseball exemplify tensions over race, nation, and language for some while simultaneously revealing baseball as a practice of latinidad, or pan-Latina/o/x identity, for others. By simultaneously exploring the ways in which Latino baseball players can appear both as threats to American values and the embodiment of the American Dream, and engaging with both archival research and new media representations of MLB players, Rudolph sheds new light on the current ambivalence of mainstream American media and fans towards Latin/o culture. David-James Gonzales (DJ) is Assistant Professor of History at Brigham Young University. He is a historian of migration, urbanization, and social movements in the U.S., and specializes in Latina/o/x politics and social movements. Follow him on Twitter @djgonzoPhD. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sports

In her incisive study Baseball as Mediated Latinidad: Race, Masculinity, Nationalism, and Performances of Identity (Ohio State University Press, 2020), Jennifer Domino Rudolph analyzes major league baseball's Latin/o American players—who now make up more than twenty-five percent of MLB—as sites of undesirable surveillance due to the historical, political, and sociological weight placed on them via stereotypes around immigration, crime, masculinity, aggression, and violence. Rudolph examines the perception by media and fans of Latino baseball players and the consumption of these athletes as both social and political stand-ins for an entire culture, showing how these participants in the nationalist game of baseball exemplify tensions over race, nation, and language for some while simultaneously revealing baseball as a practice of latinidad, or pan-Latina/o/x identity, for others. By simultaneously exploring the ways in which Latino baseball players can appear both as threats to American values and the embodiment of the American Dream, and engaging with both archival research and new media representations of MLB players, Rudolph sheds new light on the current ambivalence of mainstream American media and fans towards Latin/o culture. David-James Gonzales (DJ) is Assistant Professor of History at Brigham Young University. He is a historian of migration, urbanization, and social movements in the U.S., and specializes in Latina/o/x politics and social movements. Follow him on Twitter @djgonzoPhD. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sociology

War has raged since April 2023 between the Sudanese army under the country's de facto ruler Abdel Fattah al-Burhan and the paramilitary Rapid Support Forces (RSF), led by his former deputy Mohamed Hamdan Daglo. MedGlobal's Country Director in Sudan, Adil Almahi

A listener writes in and asks, "Matthew, What can and what cannot be mediated?" Matthew Brickman answers your most frequently asked questions about divorce as he goes over several key points:Assume nothing.Know who you are before you get married. Know who you're getting married to. Know the laws and statutes in the state you live in.Don't take advice from anyone who isn't a legal professional in the state in which you're getting married and living in.If you have a matter, disagreement, or dispute you need professional help with then visit iMediate.com - Email mbrickman@ichatmediation or Call (877) 822-1479Matthew Brickman is a Florida Supreme Court certified family and appellate mediator who has worked in the 15th and 19th Judicial Circuit Courts since 2009 and 2006 respectively. But what makes him qualified to speak on the subject of conflict resolution is his own personal experience with divorce.Download Matthew's book on iTunes for FREE:You're Not the Only One - The Agony of Divorce: The Joy of Peaceful ResolutionMatthew Brickman President iMediate Inc. Mediator 20836CFAiMediateInc.comSCHEDULE YOUR MEDIATION: https://ichatmediation.com/calendar/OFFICIAL BLOG: https://ichatmediation.com/podcastOFFICIAL YOUTUBE: http://www.youtube.com/ichatmediationOFFICIAL LINKEDIN: https://www.linkedin.com/company/ichat-mediation/ABOUT MATTHEW BRICKMAN:Matthew Brickman is a Supreme Court of Florida certified county civil family mediator who has worked in the 15th and 19th Judicial Circuit Courts since 2009 and 2006 respectively. He is also an appellate certified mediator who mediates a variety of small claims, civil, and family cases. Mr. Brickman recently graduated both the Harvard Business School Negotiation Mastery Program and the Negotiation Master Class at Harvard Law School.

It's the moment you've all been waiting for… The great Tib-bate is upon us! Angus and Atlas sit down and discuss a few points that have been causing some tension on social media. With Alec asking the questions, Angus and Atlas go back and forth on topics including: tibialis anterior training, barefoot shoes, and the use of hyperbole on social media.   If you have a topic you'd like us to discuss then leave us a voice message at the link below: https://www.speakpipe.com/hyperformancepodcast   Check out Atlaspowershrugged on instagram! (https://www.instagram.com/atlaspowershrugged/) Check out Alec Blenis on instagram! (https://www.instagram.com/alecblenis/) Check out Angus Bradley on instagram! (https://www.instagram.com/angusbradley92/) Check out Jacob Mesquita on instagram! (https://www.instagram.com/jacob__mesquita/) Check out Matt Harvey on instagram! (https://www.instagram.com/mattharvvey/)   Check out our sponsor Paieon Health!https://paieonhealth.com.au/ DISCOUNT CODES:"HYPERFLY20" at the checkout to get 20% off a Flywheel! "HYPERTIBS20" at the checkout to get 20% off a Tib-bar! For links to Angus' programs, mailing list, and other info: https://linktr.ee/angusbradley Free Accessory Bundle https://473198.myshopify.com/

In this week's episode we'll discuss the prognostic value of the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies, learn how peak ADAMTS13 activity can be used to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura, and discuss the findings from a phase 2 trial of haploidentical bone marrow transplant in sickle cell disease. Featured ArticlesReassessing the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies Peak ADAMTS13 activity to assess ADAMTS13 conformation and risk of relapse in immune-mediated Thrombotic Thrombocytopenic Purpura An international learning collaborative phase 2 trial for haploidentical bone marrow transplant in sickle cell disease 

What stands between you and your actions, between you and your life. Nick Cave, a cold tubber? And a novel in the works? Oh, yes. Ultrarunning for Normal People – ORDER YOUR COPY NOW! Coaching: Private Coaching (remote): SMALL STEP INTENSIVEOnline Program: SMALL STEPPERS MORE STUFF: PATREON BOOKS MUSIC Please support the Rancho Compasión Farm […]

Commentary by Dr. Emile Daoud

Joining Brian and myself in our virtual studio we are joined by the fantastic Richard Sparrow, Staff Clinician in Internal Medicine here at the RVC. Richard recently published a paper looking at relapse rates in immune mediated diseases (immune mediated haemolytic anaemia, immune mediated thrombocytopenia and immune mediated polyarthritis) in dogs and we thought to use this as a sounding board for a conversation about this topic, how to treat and taper immunosuppressive drugs and what do we do about ongoing preventative healthcare, such as vaccination. We hope that you enjoy.   Reference:  https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.17004 To Cite this podcast as: Dom Barfield. RVC Clinical Podcast 142 Relapse of dogs with immune mediated disease with Richard Sparrow. Published on May 17 2024 If you have any comments about this podcast, please get in touch: emailpodcast@rvc.ac.uk or follow us on instagram@rvcclinicalpodcast. We would greatly appreciate your time to rate us on Apple podcast, podbean or Acast and kindly write us a review.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/VEX865. CME/AAPA credit will be available until April 24, 2025.Interdisciplinary Approaches to Management of Immune-Mediated Inflammatory Diseases: Addressing Shared Pathophysiology With JAK Inhibitors In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, Crohn's and Colitis Foundation, National Eczema Association, and Spondylitis Association of America. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AbbVie.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/VEX865. CME/AAPA credit will be available until April 24, 2025.Interdisciplinary Approaches to Management of Immune-Mediated Inflammatory Diseases: Addressing Shared Pathophysiology With JAK Inhibitors In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, Crohn's and Colitis Foundation, National Eczema Association, and Spondylitis Association of America. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AbbVie.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/AAPA information, and to apply for credit, please visit us at PeerView.com/VEX865. CME/AAPA credit will be available until April 24, 2025.Interdisciplinary Approaches to Management of Immune-Mediated Inflammatory Diseases: Addressing Shared Pathophysiology With JAK Inhibitors In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, Crohn's and Colitis Foundation, National Eczema Association, and Spondylitis Association of America. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an independent educational grant from AbbVie.Disclosure information is available at the beginning of the video presentation.

In this episode, Milo, Greg, and Pak sit down to discuss the concept of stretch-mediated hypertrophy, from the foundational animal studies, to human stretching studies, to present day hype around stretch-mediated hypertrophy and lengthened partials. They also discuss how they're currently implementing lengthened training into their workout routines.TIME STAMPSNote: The full list of sources and notes can be found on the episode page on strongerbyscience.com/podcast-episode-132 here00:00:00 - Intro and Plugs00:11:33 - Stretch-mediated hypertrophy and hyperplasia in animals00:44:59 - Stretch-mediated hypertrophy in humans/how muscle fibers grow00:56:08 - Impact of stretching interventions on hypertrophy in humans01:44:28 - Results vs lengthened resistance training02:11:08 - Recap/takeaways from resistance training literature02:42:47 - Audience questionsWant to get your question answered on the show? Send a voice memo to podcast@strongerbyscience.com MORE FROM THE SBS TEAMWork with a Stronger By Science coach: Get personalized training and nutrition plans and ongoing support from one of our expert coaches.Join the Research Spotlight newsletter: Our newsletter is the easiest way to stay up to date with the latest exercise and nutrition science.Join the SBS Facebook group and Subreddit.RECOMMENDED PRODUCTSTry MacroFactor for free: Use code SBS to get a 14-day free trial of our nutrition app MacroFactor. MacroFactor has the fastest food logger on the market and its smart nutrition coach adapts to your metabolism to keep you on track with your goals. Download it today on the App Store or Google Play.BulkSupplements: Next time you stock up on supplements, be sure to use the promo code “SBSPOD” (all caps) to get 5% off your entire order.MASS Research Review: Subscribe to the MASS Research Review to get concise and applicable breakdowns of the latest strength, physique, and nutrition research – delivered monthly.

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Refusal in LLMs is mediated by a single direction, published by Andy Arditi on April 27, 2024 on The AI Alignment Forum. This work was produced as part of Neel Nanda's stream in the ML Alignment & Theory Scholars Program - Winter 2023-24 Cohort, with co-supervision from Wes Gurnee. This post is a preview for our upcoming paper, which will provide more detail into our current understanding of refusal. We thank Nina Rimsky and Daniel Paleka for the helpful conversations and review. Executive summary Modern LLMs are typically fine-tuned for instruction-following and safety. Of particular interest is that they are trained to refuse harmful requests, e.g. answering "How can I make a bomb?" with "Sorry, I cannot help you." We find that refusal is mediated by a single direction in the residual stream: preventing the model from representing this direction hinders its ability to refuse requests, and artificially adding in this direction causes the model to refuse harmless requests. We find that this phenomenon holds across open-source model families and model scales. This observation naturally gives rise to a simple modification of the model weights, which effectively jailbreaks the model without requiring any fine-tuning or inference-time interventions. We do not believe this introduces any new risks, as it was already widely known that safety guardrails can be cheaply fine-tuned away, but this novel jailbreak technique both validates our interpretability results, and further demonstrates the fragility of safety fine-tuning of open-source chat models. See this Colab notebook for a simple demo of our methodology. Introduction Chat models that have undergone safety fine-tuning exhibit refusal behavior: when prompted with a harmful or inappropriate instruction, the model will refuse to comply, rather than providing a helpful answer. Our work seeks to understand how refusal is implemented mechanistically in chat models. Initially, we set out to do circuit-style mechanistic interpretability, and to find the "refusal circuit." We applied standard methods such as activation patching, path patching, and attribution patching to identify model components (e.g. individual neurons or attention heads) that contribute significantly to refusal. Though we were able to use this approach to find the rough outlines of a circuit, we struggled to use this to gain significant insight into refusal. We instead shifted to investigate things at a higher level of abstraction - at the level of features, rather than model components.[1] Thinking in terms of features As a rough mental model, we can think of a transformer's residual stream as an evolution of features. At the first layer, representations are simple, on the level of individual token embeddings. As we progress through intermediate layers, representations are enriched by computing higher level features (see Nanda et al. 2023). At later layers, the enriched representations are transformed into unembedding space, and converted to the appropriate output tokens. Our hypothesis is that, across a wide range of harmful prompts, there is a single intermediate feature which is instrumental in the model's refusal. In other words, many particular instances of harmful instructions lead to the expression of this "refusal feature," and once it is expressed in the residual stream, the model outputs text in a sort of "should refuse" mode.[2] If this hypothesis is true, then we would expect to see two phenomena: Erasing this feature from the model would block refusal. Injecting this feature into the model would induce refusal. Our work serves as evidence for this sort of conceptualization. For various different models, we are able to find a direction in activation space, which we can think of as a "feature," that satisfies the above two properties. Methodolog...

This episode we are going to explore Aura, or emotionally mediated synaesthesia. Zoe and I have lived experience with this form. Our guest Richard Cytowic, Professor for Neurology, will tell us about the his perspective on the phenomenon. Thank you for sending in your experiences to! Keep them coming, I'm curious to hear what distinctions you would use. Connect with us: @maikepreissing www.maikepreissing.com @zoesthesia www.zoesthesia.com Prof Richard Cytowic, Professor for Neurology, Washington DC, USA --- Send in a voice message: https://podcasters.spotify.com/pod/show/maike-preissing/message

Dr. Stacey Clardy talks with Dr. Reghann LaFrance-Corey to discuss her paper "Evaluation of the diagnostic utility of caveolae-associated protein 4 (cavin-4) epitope-based ELISA in identification of immune mediated rippling muscle disease." Show reference:  https://index.mirasmart.com/AAN2024/PDFfiles/AAN2024-003093.html

References Guerra, D. 2024. Previous Lectures: Authentic Biochemistry. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Waters, R.1973. "Eclipse" from [Dark Side of the Moon]; Pink Floyd lp. https://youtu.be/k0xGxnZFNYs?si=VrfYPQuXef41Drfm Holst, G. 1918. "The Planets" https://youtu.be/HP5xhyPn58U?si=IdN_iqJNvt_tjQKP --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Redox Biol. 2020 Apr; 31: 101482 Nat Rev Microbiol. 2009 Feb; 7(2): 99–109. J Neuroinflammation. 2019; 16: 236. Front Pharmacol. 2021; 12: 643254. Biber, H. 1676. "Passagalia" por solo violin https://youtu.be/sgcR183f8gA?si=ovfSbdg6WsfuIiTw McBroom, A. 1976. "The Rose" Conway Twitty https://youtu.be/cO59ITNCxzk?si=ueMmXtzMNH4YeQ_w Hunter-Weir. 1970. "Sugar Magnolia" American Beauty L.P. https://youtu.be/ei5EmN2HmVI?si=6ZrBBPmu3cMyMOAO --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Front Immunol. 2020; 11: 591803 Am J Gastroenterol. 2004 Nov;99(11):2147-9. Biochem Biophys Res Commun. 2005 Dec 16;338(2):1031-6 Front Immunol. 2019 Jun 7;10:1309. FASEB J. 2021 May; 35(5): e21439. Hildegard von Bingen 1150.- "Canticles Of Ecstasy --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Front Immunol. 2019 Jun 7;10:1309. JBC 2024 . March.Article in PressDOI:https://doi.org/10.1016/j.jbc.2024.107173 FASEB J. 2016 Dec;30(12):4202-4213. Nat Rev Gastroenterol Hepatol . 2020 Feb;17(2):93-110 Bach , JS. 1731. Piano Partita No. 2 In C Minor, BWV 826 https://youtu.be/f-OdOuNZciQ?si=AmFtC5CX3x2ndzdV Slade,Mann, and Rogers. 1975 "Time is Right" Manfred Mann https://youtu.be/jzJIej8h5q4?si=3-aCFe0tqur4lfX1 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

The explosion in diagnostic tools to identify immune-mediated myelopathies has led to much more precise diagnosis and treatment of these patients, but also created gaps in knowledge. In this episode, Kait Nevel, MD speaks with Michael Levy, MD, PhD, FAAN author of the article “Immune-Mediated Myelopathies,” in the Continuum February 2024 Spinal Cord Disorders issue. Dr. Nevel is a Continuum® Audio interviewer and a neurologist and neuro-oncologist at Indiana University School of Medicine in Indianapolis, Indiana. Dr. Levy is an associate professor at Massachusetts General Hospital and Harvard Medical School in Boston, Massachusetts.  Additional Resources Read the article: Immune-Mediated Myelopathies Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @IUneurodocmom Guest: @mlevy18 Transcript  Full transcript available on Libsyn Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, a companion podcast to the journal. Continuum Audio features conversations with the guest editors and authors of Continuum, who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article by visiting the link in the show notes. Subscribers also have access to exclusive audio content not featured on the podcast. As an ad-free journal entirely supported by subscriptions, if you're not already a subscriber, we encourage you to become one. For more information on subscribing, please visit the link in the episode notes. AAN members, stay tuned after the episode to hear how you can get CME for listening. Dr Nevel: This is Dr Kait Nevel. Today, I'm interviewing Dr Michael Levy on immune-mediated myelopathies, which is part of the February 2024 Continuum issue on spinal cord disorders. Dr Levy is an Associate Professor at Massachusetts General Hospital in Harvard Medical School in Boston, Massachusetts. Welcome to the podcast. Thank you so much for being here today and chatting with me about your article. I really enjoyed reading your article. I read through it, and it felt like, you know, just really enjoyable. I had no concept of time when I was reading it. I encourage all of the listeners to read the article, too. I'll start with just a really broad question, with - what is the most important, clinically relevant thing from your article that you'd like the neurologist listening today to know? Dr Levy: I would say that the group of conditions in which the immune system can attack the spinal cord are growing. We're getting better at identifying the specific antigens, like in the case of NMO neuromyelitis optica and in MOG antibody disease. We're getting better at identifying targets for treatment, like with neurosarcoidosis - identifying those biologics that seem to help. And then, we're even beginning to characterize some of the idiopathic forms, some of which follow covid, or vaccines, or other conditions. I think the message is that we're getting a lot better out there, and if you have a case of inflammation in the spinal cord, then this is something that has a good workup now (and people should be paying attention to articles like this that give them an idea for how to work this up), and then the most appropriate treatment. Dr Nevel: Right. And not to get too much “in the weeds,” but in your article, you really outlined very nicely an algorithm or stepwise approach in evaluating patients with suspected immune-mediated myelopathies. Could you just briefly go through the general principles of that evaluation and stepwise approach, and what you would consider really necessary tests to order for these patients? Dr Levy: Sure. I would say that the first thing that you want to do is to make sure that it's inflammatory. And to do that, we have – the blood tests are few and far in between. If you're dealing with inflammation in the spinal cord, the few ways that we have to convince ourselves that there's truly inflammation - there are MRI and spinal fluid - and those objective tests need to be considered in the appropriate clinical context. The order of events is: patient comes in, reports certain neurological functions that localize to the spinal cord - that's step one, Step two, neurological exam that confirms that there's a neurological problem that localizes to the spinal cord. And then, numbers three, four, five are objective workups, including MRI of the spinal cord and other parts of the neuraxis, CSF testing, and blood testing, all of which then support your differential diagnosis. For each diagnosis, that order is the same, and it should always result in an answer for you, which ultimately may all be negative (and then we have a plan for that, too). If all your workup is negative, you don't know what caused it - at least a plan to deal with that as well. Dr Nevel: Building off of that - in your article, you mentioned that there are shared features between the different immune-mediated myelopathies. We have some tests that can help us differentiate, but what are some of the limitations or strengths of our currently available diagnostic evaluations - our clinical clues to help us differentiate between the different types? Dr Levy: The biggest limitation, of course, is that it's hard to access the spinal cord. We're not going to biopsy almost any patient unless we really have to rule out cancer. Otherwise, we don't want to take a punch out of a very small spinal cord that's carrying a bunch of fibers going in and out of the brain. So, that is our biggest limitation. We can't physically see it under the microscope, so we have to infer what's going on with MRIs and spinal fluid. And of course, spinal fluid isn't necessarily directly in touch with the inflammation - it could just be around it and bathing it. But we're hoping that there are clues from the spinal cord that shed into the spinal fluid that we can detect by lumbar puncture. I do think that we're getting better and also we're identifying things in the bloodstream that could also impact the spinal cord. And of course, blood tests are much easier to do, and some of these blood tests look for antibodies, which we know last for months and months. So, even if a person is having trouble getting their workup done on time, these antibody tests are still useful, even months after onset. Dr Nevel: Yeah. In your opinion, what have been some of the bigger breakthroughs? And I know there's been a lot in immune-mediated myelopathies over, let's say, the past five to ten years. That's a long timeframe, and I know a lot of things have happened during that timeframe – but what do you think has made the biggest impact in either evaluation and/or treatment for these patients? Dr Levy: When I was training, everything in the spinal cord was always MS. It was just - everything was multiple sclerosis in this big bucket of MS that we thought was heterogeneous. Now we're identifying the biomarkers that actually are distinguishing these patients from MS. We know what the immune system is targeting now in many of these conditions. Then, based on that immunological pathway, there are drug targets that have been developed. So, for even a very small disease, with 20,000 people in the US (one in 100,000) who have neuromyelitis optica, we now have three FDA-approved drugs because the science is so well worked out. And now there are two trials in MOG antibody disease, for example. As we identify new biomarkers based on the antigen specificity of the disease, I think we're going to have more and more specific therapies for each of these conditions, even if they're rare diseases. Dr Nevel: Yeah, that's great. Thanks for mentioning those, and I urge the listeners to check out the article to read a little bit more about some of those treatments for NMO spectrum disorder and MOG antibody disease that are in trials. What's the most common mistake that clinicians can make when evaluating or treating patients with immune-mediated myelopathies. What should we watch out for or to try to avoid doing? Dr Levy: I would say, at the beginning, there might be an urge to overtreat because we know that “time is spinal cord” - we don't want to waste time; we don't want to lose time. Some clinicians might just be inclined to give high doses of steroids, even in cases that they're not sure are inflammatory. The big overlap here is especially in older people who might have vascular myelopathy, where steroids might make things worse and it might delay their care. So that's the first problem – is, when physicians rush to judgment. Then the other big problem is when they take their time, and they say, “Well, this is just multiple sclerosis, probably. And we know that, in the end, MS patients do the same whether they're treated or not treated, and so we can take our time with this.” Whereas if we know that this is actually NMOSD, time is spinal cord and destruction is ongoing and potentially irreversible. I would say that there's problems on both sides of the time window. My approach is to be aggressive very early on and try to identify whether or not it's inflammatory. And then if it's not, then you can take a step back and go to the other chapters in this continuum - try to figure out what this is – and if it is inflammatory, then you definitely want to get on top of the treatment. Dr Nevel: Yeah, finding that sweet spot; making sure that you're not waiting too long but that you're not treating inappropriately or the wrong thing. So, what do you think - let's say you have a patient with an immune-mediated myelopathy; you've diagnosed them, they're undergoing treatment. What's the most challenging part of ongoing management of a person who has an immune-mediated myelopathy? Dr Levy: I would say that one of the most satisfying parts of my career lately has been that we're good at preventing the next attack once we know what the disease is. So, for NMO and for MOG and MS, we're good at that. We can suppress the immune system or modulate it in a way that we're preventing the next attack from occurring, and patients are excited about that. But when they come into clinic and I say, “Great job, no new attacks,” then they look at me and they go, “But how do I get out of my wheelchair now?” Because the damage done from prior attacks is not touched by any of these meds. So, there's a huge unmet need in that area of regeneration and recovery of function because, while it's all great that we can prevent the next attack and with all these great drugs that are approved, patients are still suffering. They have mobility problems, bowel/bladder problems, and pain, especially neuropathic pain, that really causes a lot of disability, and that's from damage that's already done. It's the same as spinal cord injury from trauma or from tumors or whatever - the spinal cord injury is the same and there's still a huge unmet need in that area. Dr Nevel: On that note, who else do you usually consider part of the team, if you will - who else should be involved in the management of these patients? Dr Levy: A lot of people. We have urologists involved for bladder, we have physical therapists involved for mobility, and occupational therapy for things related to hand and hand function. We have psychiatrists related to mental illness and also just dealing with these issues, because even if you don't have clinical depression, you still have an adjustment from the disease process and from all the treatments. Social workers, because this is a huge financial burden for a lot of people. An often rheumatologists, because NMO, for example, has about 25 percent overlap with other diseases. We don't want to double treat - we'll often choose a treatment that's applicable to both the rheumatologic disease and the neurological disease. So, I'd say that we don't work alone in almost any case; it's usually quite a big team involved. Dr Nevel: One of the questions that I always like to ask is, what do you think the next big breakthrough is going to be in immune-mediated myelopathies? What's most exciting to you - what do you think is on the horizon here? Dr Levy: I think probably the most exciting area is in multiple sclerosis, where we're starting to understand the role of the Epstein-Barr virus in triggering the disease, and potentially, even in driving the disease. Up to now, we've been suppressing immune systems in people with MS. But maybe we should be looking more at how can we prevent MS from occurring in the first place. And in cases where MS has already started, how does the virus play a role, and can we potentially modulate the outcome of disease with something like antivirals against EBV? So, I think that's the huge, exciting area. It's dominating a lot of the conversations at neuroimmunology conferences. But I think it's well worth the investigation because if MS turns out to be just an Epstein-Barr virus infection, I think a lot of what we've been doing up to now might not be as relevant. So, this is something that's very important. Dr Nevel: Yeah - to have a way to prevent disease rather than treating it after, too, would be a super powerful thing. Dr. Levy: And there are lots of Epstein-Barr virus vaccines that are being developed. But then the question comes up, “Well, are we going to prevent one in a thousand people from getting MS by vaccinating all thousand kids?” Is that really worth it? Can we pick out the ones who are more high risk for developing MS and just vaccinate those kids? A lot of ethical questions involved in that, too. Then what happens if we don't let our population get infected with EBV? We've evolved with that virus for hundreds of thousands of years. What if we abolish it all of a sudden - what does that do? Does it have any implications? I don't know. Dr Nevel: Yeah, lots of really complicated things to think through, with exciting potential but a lot of unknowns. Dr Levy: A lot of unknowns. Dr. Nevel: Talking about patients with seronegative relapsing transverse myelitis - what's your general approach to those patients? When you feel like you've exhausted the extent of your workup but they have a relapsing transverse myelitis, how do we approach those patients and take care of them? Dr Levy: “Seronegative” refers to patients who test negative for aquaporin-4, which is NMO, and test negative for MOG antibody disease (so they are double seronegative), but they have a recurring disease that looks an awful lot like one of the two. We generally stratify these patients into the “aquaporin-4-like,” “MOG-like” or “MS- like.” So, we try to put them into a category even if they're seronegative because we think that the treatments would be the same. So, for the MOG-like, for example: these are patients who have recurring attacks; they're not necessarily all long, but they do tend to remyelinate, and they can be severe at first but then they do get better over time. That's “MOG-ish,” so we treat those people with MOG treatments. Whereas people who have this sort of aquaporin-4 type, they have severe attacks and they really don't get better, and they have a lot of necrosis if you look at it under the microscope. And those people we tend to treat with aquaporin-4 NMO drugs. And then we have the MS type that kind of lingers or is more focal white matter lesions. Even if they don't have a lot of brain lesions, they might be oligoclonal band-positive; we put them in the category of MS. But we have a very active research effort to identify new antibodies in case any of these diseases that are seronegative and don't fit into any category - it's certainly possible that there's an antigen of their own that they're attacking, so we'd like to try to identify that in these novel assays that we're doing in the lab. Dr Nevel: How do you counsel patients on what to expect in the future, who you're seeing in the hospital with their first episode of transverse myelitis, for whatever the cause? Because one of the biggest questions I suspect most patients ask is, “Am I going to get better? Is this going to happen to me again?” How do you navigate those tough discussions, and what do you tell patients? Dr Levy: In the hospital, it's tough, because a lot of our testing takes time - it takes ten, fourteen days. So, in the hospital, I say, “Look, we're going to focus on here and now - we're going to suppress the inflation; we're going to try to get you better from this event.” It could have been a severe optic neuritis or transverse myelitis, or brain stem injury, or whatever - we're going to try to focus on that. And then I say, “When you come back to my clinic, we'll have the results from all of your testing and we're able to talk about the future and how to prevent the next one, if we have to.” It does take time, unfortunately, to get all that data back, and it is a little bit suspenseful for patients, but that's what we have at the moment. Dr Nevel: Yeah, the most honest answer that you can give them is always the best one. And that's the scenario when you're in the hospital - that there just isn't full answers. Dr Levy: Yeah. One of the reassuring things I can say is, “We have a lot of medications that target different parts of the immune system, so no matter what you have, we can probably treat it.” Dr Nevel: Right. Obviously, really important to give people a sense of hope and reassurance that you're there and you're going to help find a treatment that's going to help them in the future. Well, thank you so much for chatting with me today. I really enjoyed our conversation and reading your article and learning more about immune-mediated myelopathies. Dr Levy: It's been a pleasure. Thank you. Dr Nevel: Thank you, Dr Levy, for joining me on Continuum Audio. Again, today we've been interviewing Dr Michael Levy, whose article on immune-mediated myelopathies appears in the most recent issue of Continuum, on spinal cord disorders. Be sure to check out Continuum Audio podcasts from this and other issues, and thank you to our listeners for joining us today. Dr. Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, please consider subscribing to the journal. There's a link in the episode notes. We'd also appreciate you following the podcast and rating or reviewing it. AAN members: go to the link in the episode notes and complete the evaluation to get CME for this episode. Thank you for listening to Continuum Audio.

In this week's episode Pastor Trice talks about the pitfalls for our children of having an online social life, and especially how parents can be proactive in their instruction when their children venture into the world of social media.

Characterized by the presence of others (מַלְאָכִים) and a smoke-filled room

What are things you should consider when approaching a case with an immune mediated disease?Check out this week's episode of The Derm Vet podcast!

Mediated Series - Part 7:Published in 2005, Mediated: How the Media Shapes Your World and the Way You Live In It, became Bridget's bible for understanding the changing media landsc ape and how it is affecting our society and behavior. Now she sits down with author Thomas de Zengotita for a multi-part series discussing the book chapter by chapter. Thomas de Zengotita returns to continue the discussion about his book Mediated. This week he and Bridget cover the paradox of authenticity, how you can't be self-conscious about who you are and still be authentic, how we're all essentially performing our "true selves," and how the only real thing in today's mediated culture is an accident. They cover the amount of time we spend in between the screen world and the real world, choosing between the versions of yourself that you're constantly playing, being busy is a way of being “somebody,” why the ultimate form of mediation is language itself, why progressives who are always right are phony progressives, how people are less likely to be depressed or anxious when they're absolutely certain of stuff, when the absence of stimulation causes panic, the difference between witnessing & rubbernecking, and what it means to live a life of doubt. Sponsor Links: Patriot Gold - Call 888-614-9238 We Are Not Journalists Podcast - https://spoti.fi/3R0a0bZ Pluto TV - https://bit.ly/WiWPlutoTV

Mediated Series - Part 7: Published in 2005, Mediated: How the Media Shapes Your World and the Way You Live In It, became Bridget's bible for understanding the changing media landsc ape and how it is affecting our society and behavior. Now she sits down with author Thomas de Zengotita for a multi-part series discussing the book chapter by chapter.Thomas de Zengotita returns to continue the discussion about his book Mediated. This week he and Bridget cover the paradox of authenticity, how you can't be self-conscious about who you are and still be authentic, how we're all essentially performing our "true selves," and how the only real thing in today's mediated culture is an accident. They cover the amount of time we spend in between the screen world and the real world, choosing between the versions of yourself that you're constantly playing, being busy is a way of being “somebody,” why the ultimate form of mediation is language itself, why progressives who are always right are phony progressives, how people are less likely to be depressed or anxious when they're absolutely certain of stuff, when the absence of stimulation causes panic, the difference between witnessing & rubbernecking, and what it means to live a life of doubt.Sponsor Links:Patriot Gold - Call 888-614-9238We Are Not Journalists Podcast - https://spoti.fi/3R0a0bZPluto TV - https://bit.ly/WiWPlutoTVBridget Phetasy admires grit and authenticity. On Walk-Ins Welcome, she talks about the beautiful failures and frightening successes of her own life and the lives of her guests. She doesn't conduct interviews—she has conversations. Conversations with real people about the real struggle and will remind you that we can laugh in pain and cry in joy but there's no greater mistake than hiding from it all. By embracing it all, and celebrating it with the stories she'll bring listeners, she believes that our lowest moments can be the building blocks for our eventual fulfillment.Beyond Parody with Bridget Phetasy is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.phetasy.com/subscribe