Podcasts about Rare

When your newborn is healthy one moment and rushed to the PICU the next, life can change in an instant. Today's guest joins us to share her son's journey with severe hemophilia—from unexpected bleeding after a routine circumcision to a spontaneous brain bleed, emergency surgery, and a months-long PICU stay. This episode explores being thrust into medical motherhood, learning to advocate under unimaginable stress, and how community, child life, and modern medicine help families navigate life with a complex diagnosis. Download our free Children's Hospital Passport to help empower your child and family during hospital stays. Sponsored in part by HealthWell Foundation—learn how you can help families afford life-saving medications at healthwellfoundation.org. Resources Medical Support: Mayo Clinic Children's Center & Hemophilia Treatment Center, Rochester, MN Nonprofit & Community Support: Hemophilia Foundation of Minnesota & the Dakotas Connect with Sami Follow Sami and Cooper's journey on Instagram  Connect & Support from Child Life On Call  Subscribe: Never miss an episode on Apple Podcasts or Spotify. Visit insidethechildrenshospital.com to easily search stories and episodes Follow us on Instagram for updates and opportunities to connect with other parents Download SupportSpot: receive Child Life tools at your fingertips. Leave a Review: It helps other families find us and access our resources! Keywords: Severe hemophilia, Hemophilia in infants, Newborn hemophilia diagnosis, Infant brain bleed, Pediatric hemophilia, Medical motherhood, PICU parent experience, Emergency brain surgery infant, Rare disease parenting, Bleeding disorders in babies, Hemophilia treatment center, Parent advocate in healthcare, Life after a NICU or PICU stay, Medically complex child, Child life specialist support, Coping with a chronic diagnosis, Parenting after medical trauma, Hemophilia A awareness, Infant seizures medical emergency, Hospital parent support Medical information provided is not a substitute for professional advice—please consult your care team.

Ian Klemm is back with a collection of straight pull rifles of different designs and eras. Tune in as he details the intricacies of each, gives us some history, and is his eternally interesting self.As always, we want to hear your feedback! Let us know if there are any topics you'd like covered on the Vortex Nation™ podcast by asking us on Instagram @vortexnationpodcast

Ahoy Pirates, this week in Sea of Thieves, we have a couple of videos from Rare that cover some more details about the upcoming update this week. It's light for news otherwise, so we're keeping things steady until we get some patch notes. The Gold Hoarder episode is next week, as we'll be sitting down with some folks to talk about the update. Support: https://www.patreon.com/keelhauledpodcast Contact Info: Bluesky: https://bsky.app/profile/captlogun.bsky.social Email: Captlogun@gmail.com Twitter: https://twitter.com/capt_logun Twitch: https://www.twitch.tv/capt_logun Gamertag: CaptainLogun Community: Keelhauled Podcast Discord: https://discord.gg/5VRabwR Other Places to Listen: iTunes: https://itunes.apple.com/us/podcast/keelhauled-a-sea-of-thieves-podcast/id1351615675?mt=2 Spotify: https://open.spotify.com/show/2BrEqA6prz6t31wlFgaWaS Merch: Teespring: https://teespring.com/stores/keelhauled-podcast  

Bestselling author Michael Lewis has spent decades practicing the habits of the sharpest business thinkers: questioning assumptions, navigating past blind spots, and revealing why conventional wisdom so often leads smart people astray. Lewis is the author of a remarkable run of business bestsellers, including Liar's Poker, Moneyball, Flash Boys, The Big Short, Boomerang, The Undoing Project, and Going Infinite. Both Moneyball and The Big Short were made into Oscar Best Picture-nominated films, as was The Blind Side, another of Lewis's non-fiction classics.  In this exclusive episode of Monday Morning Radio, Lewis reflects on why true success derives from taking the long view rather than aiming for quick results, and how doing the hard, unglamorous work others avoid can create an outsized, enduring advantage.  Lewis's conversation with founding Monday Morning Radio host Dean Rotbart was recorded when the author was honored as a Business News Visionary. While the interview dates back several years, in this abridged version of their talk, the insights Lewis shares are strikingly current — offering inspired ideas that apply to entrepreneurs, executives, and business owners navigating uncertainty, disruption, and change today. [Michael Lewis will be featured in All You Can Eat Business Wisdom: Second Helpings, coming in April 2026. The anthology is the sequel of co-host Maxwell Rotbart's award winning first edition, All You Can Eat Business Wisdom: A Monday Morning Radio Anthology of Actionable Advice.] Monday Morning Radio is hosted by the father-son duo of Dean and Maxwell Rotbart. Photo Credit: Tabitha Soren Posted: January 19, 2026 Monday Morning Run Time: 49:22 Episode: 14.33 The Great Writers Series from Roy H. Williams: YouTube Shorts HemingwayTalks About Pamplona

Get 25% off monthly or annual Patreon memberships now through January 31 at http://www.Patreon.com/KitAndKrysta with code KITANDKRYSTA*~*~*~*~*~*~*~*~*~*~*~*~*Hello and welcome to episode 205 of the Kit & Krysta Podcast! We're so excited because we have video game music icon Grant Kirkhope with us today to talk about so many things including his time at Rare, how Banjo-Kazooie got added to Super Smash Bros. Ultimate and why he STILL hasn't seen The Super Mario Bros. Movie. Also in this episode, we react to some sales information we have about Nintendo Switch 2's first ever holiday. What does this mean for the future of Nintendo? We're also playing some new games including a party game that actually might be better than Mario Party! All this and more is coming right up! 0:00 - Cue the Goldeneye pause music! 10:00 - News! (Reacting to Nintendo Switch 2's holiday sales, new Pokemon Lego sets, Call of Duty coming to Switch 2 rumors, Xbox Developer Direct)48:29 - Games we're playing (Ghost of Yotei, Death Stranding 2, Big Hops, Suika Game Planet, Lego Party) 1:18:48 - Welcome Grant Kirkhope!Patreon Shoutouts! - All Hail the Final Boss - Aaron Hash - Thank you Super Stars: MaruMayhem, Eigenverse, Mike Chin, Roy Eschke, vgmlife, Link The Hero of Winds, Angela Bycroft, Thomas O'Rourke, Kyle LeBoeuf, Andrew Youhas, Chilly, krashuri, Master Discord, Travis Torline, EchoLadair, MSMPokeGamer, RBurns, KITT 10K, Adrien, Nafon Clover, TheSharkAmongMen, RainTech, KissMyFlapjack, Paul Gale Network, Cameron, Fredrik Ulf KonradssonFollow Us! https://www.patreon.com/kitandkrystahttps://twitter.com/kitandkrystahttps://www.tiktok.com/@kitandkrystahttps://www.instagram.com/kitandkrysta/http://www.facebook.com/kitandkrysta/https://bsky.app/profile/kitandkrysta.bsky.social-Kit & Krysta

In this Episode of The Bourbon Life Podcast, Matt and Mark spend some time in The Bourbon Life Studios hanging out with our good friend and Bourbon Life Crew Member, Chad Watson, Blending & Operations Manager, for Rare Character. Chad was previously a guest on Episode 199. The guys talk with Chad about his background in retail and how his passion for Bourbon and writing reviews on Instagram led him to a position with Rare Character, the meteoric rise of Rare Character and the almost cult-like status that it has obtained amongst Bourbon drinkers and fans, and the new line extensions that Rare Character has released since his last appearance and how Rare Character is working to continue focusing on its core business that brought it so much success while also developing these new line extensions to reach a broader audience. They also taste and review several of the newer line extensions from Rare Character including their Hurst Knoll Kentucky Straight Rye Whiskey, their 15-Year Brook Hill Kentucky Straight Bourbon, and their Old Cassidy Kentucky Straight Bourbon. This Episode is sponsored by District 7 and The Kitchen Table at the James B. Beam Distilling Co.

Alex and former pro player Marc Anderson review all the rares and mythics in Lorwyn Eclipsed  Limited Level-Ups Patreon: https://www.patreon.com/limitedlevelups LLU Tierlist: https://www.17lands.com/tier_list/1745e64176864bb2bec132cbd601b604 Limited Level-Ups Discord: bit.ly/jointhedischord Alex's Stream: https://www.twitch.tv/chord_o_calls Limited Level-Ups Podcast:https://limitedlevelups.libsyn.com/ Alex's Coaching Email: chordocoach@gmail.com UntappedGG Affiliate Link (download today! It helps the channel) : https://mtga.untapped.gg/companion?utm_medium=affiliate&utm_campaign=chordocalls

Tom Brady makes rare comments about divorce, Tim Allen reveals mentoring his Home Improvement "Sons" was a challenge and Ashton Kutcher talks Demi Moore.Kelli Foster Warder, Director and the lead Erin Capello from 'Kiss Me Kate' are in Studio to talk about the show at the Bloomington Center of the Arts from Jan 22nd to Feb 15th. Details hereSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On this episode, we kick things off with BIG news — I'll be at the NAMM Show next week, bringing you exclusive, on-the-floor NAMM coverage right here on Johnny Beane TV. Make sure you're subscribed so you don't miss a thing! Ron also unboxes a special edition MXR Distortion Plus Randy Rhoads “The Concorde” pedal, courtesy of @MusicTherapyLaz - We put it head-to-head with the current yellow Distortion Plus and the polka-dot version to hear all three side-by-side! https://youtu.be/e5UCZJr36Zs Then it's on to music news, including Norman's Rare Guitars — the legendary LA vintage shop — being acquired by TNAG Global, the parent company of Carter Vintage Guitars and Cotton Music Center. We also check out Nuno Guitars, Nuno Bettencourt's new guitar company, exploring the Thoroughbred, Stable, Colt series, and acoustic models now live on the site. Plus, I recap last weekend's Amigo Guitar Show, and we look ahead to Workbench Saturday, where we'll be doing hands-on guitar work right here on the channel.

Trois diagnostics en quelques mois, une maladie rare et une vie loin de la France.Dans ce premier épisode de Tuile d'Expat', Nelly Funk raconte son parcours avec un diabète cétodépendant, une forme encore méconnue, même de certains professionnels de santé.Diagnostiquée à Londres, elle a dû apprendre à naviguer dans un système médical étranger, faire ses propres recherches et devenir patiente experte pour comprendre ce que son corps vivait réellement.Un témoignage intime et éclairant sur le diabète, le poids des étiquettes médicales, la nécessité de s'informer et la réalité du quotidien avec une maladie chronique quand on est expatriée.Les ressources dont Nelly parle dans les épisodes sont les suivantes :Le compte insta de Diabetic Doctor : https://www.instagram.com/temidiabeticdoctor?igsh=eHV4a2FwMzlhbTZhLe compte insta insuleoin : https://www.instagram.com/insuleoin?igsh=MWZzeThnMWg3MmV0Zg==Le compte insta de Mathew L Carter : https://www.instagram.com/mathewlcarter?igsh=ZWxzZTFhZm9xM2p6Une mini-série rendue possible grâce au soutien de la CFE.French Expat est un podcast de French Morning qui raconte les parcours de vie des Français établis hors de France. Retrouvez-le sur toutes les plateformes d'écoute : Spotify, Apple Podcast, Deezer, Google Podcast, Podcast Addict, Amazon Music. Cet épisode est raconté, produit et réalisé par Anne-Fleur Andrle, habillé et mixé par Alice Krief. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

You know that feeling when you're constantly putting out fires instead of actually building your business? Yeah, me too. After a handful of years of running my business reactively—scrambling to create content, adjusting to life transitions, and well, simply surviving—I'm  ready to build something more strategic, sustainable, and dare I say...enjoyable. In this Season 5 kickoff of Talk Copy to Me, I'm pulling back the curtain on my 2026 plans. You'll hear about the shifts I'm making, the programs I'm working on, the stages I'm already booked to speak on, and why I built an entire personal creative project (that lasts throughout the year!) to avoid burning out with work and work only. If you're also coming out of survival mode and ready to be more strategic, this one's for you.______________________________________________ EPISODE 177.Read the show notes and view the full transcript here: Coming soon!______________________________________________Here's the info on your host, Erin OllilaErin Ollila believes in the power of words and how a message can inform – and even transform – its intended audience. She graduated from Fairfield University with an M.F.A. in Creative Writing, and went on to co-found Spry, an award-winning online literary journal.When Erin's not helping her clients understand their website data or improve their website copy, you can catch her hosting the Talk Copy to Me podcast and guesting on shows such as Profit is a Choice, Mindful Marketing, The Power in Purpose, and Business-First Creatives.Stay in touch with Erin Ollila, SEO website copywriter:• Learn more about my VIP intensive options or just book a strategy session to get started right away• Visit Erin's website to learn more about her business, services, and products

Welcome to John Poz and TMPT's 11th Year Anniversary special. Today's RARE flagship interview podcast episode features 2x WCW Tag team and WCW TV champion, Perry Saturn. On this show the former WWF European and Hardcore champion will discuss his entire professional wrestling career. Host John Poz and Saturn will discuss breaking into the business, WWF, WWE, Vince McMahon, the Radicalz, ECW, Paul Heyman, WCW, Eric Bischoff, his legacy, NJPW, USWA, and so much more!Store - Teepublic.com/stores/TMPTFollow us @TwoManPowerTrip on Twitter and IG

*Leçon n°284 : Dégustation rare : Château Margaux expliqué simplement (et comment vous pouvez le goûter vous aussi)* : --------------------------------------- Connaissez-vous réellement Château Margaux, l'un des vins les plus mythiques du Médoc ? Premier Cru Classé en 1855, noté 20/20, symbole d'élégance absolue… mais que trouve-t-on vraiment dans un verre de Margaux ? Dans cette vidéo, je vous emmène au cœur de ce domaine surnommé « le Versailles du Médoc », pour comprendre : - pourquoi son terroir de graves est unique - comment son climat modèle des vins d'une finesse incomparable - le rôle essentiel du cabernet sauvignon dans sa signature aromatique - et surtout… à quoi ressemble son goût légendaire Au programme : - un rappel historique clair et passionnant - l'explication du terroir (croupes, drainage, exposition, climat…) - les cépages clés du Grand Vin - une dégustation commentée en direct, simple et accessible et la solution pour pouvoir vous aussi goûter Château Margaux… sans ouvrir une bouteille à plusieurs centaines d'euros. Vous êtes passionné(e) de vin, curieux des grands crus ou simplement amateur de belles découvertes ? Suivez le guide : je vous montre tout dans cette vidéo de quelques minutes. *Suivez-moi sur les Réseaux Sociaux* : ---------------------------------------- Suivez-moi sur Instagram : https://www.instagram.com/yann_rousselin_lecoam/ Rejoignez-moi sur Facebook : https://www.facebook.com/LeCOAM Découvrez mes vidéos sur TikTok : https://www.tiktok.com/@yannrousselin.lecoam *Pour Aller Plus Loin* ---------------------------------------- Formez-vous au vin sur http://www.lecoam.eu Rejoignez le 1er Club à distance pour vivre sa passion du vin : https://club-du-degustateur.com/ Retrouvez tous mes articles et podcasts ici : https://www.le-vin-pas-a-pas.com/ *Rejoignez d'autres passionnés de vin dans mon groupe Telegram !* --------------------------------------- https://t.me/lecoam J'y partage des astuces de dégustations, des schémas, des vidéos… (Si vous ne connaissez pas Telegram, c'est un peu comme WhatsApp, en plus sécurisé. Vous pouvez l'installer gratuitement sur votre smartphone ou tablette sur https://telegram.org/)

Amber Freed transformed the shock of her son's diagnosis with an ultra-rare neurodevelopmental disorder into a determined campaign for gene therapy. With no clinical roadmap, sparse literature, and doctors offering only symptomatic care, she taught herself biology basics, established a nonprofit, and assembled a scientific team. She focused on gene replacement therapy as the most viable path, and son became the first patient treated in a clinical trial of the experimental gene therapy last September. We spoke to Freed, founder and CEO of SLC6A1 Connect, about how a parent with no scientific background catalyzed the development of the first experimental gene therapy for SLC6A1-related disorder, mobilized scientists, and what other rare disease communities can learn from her journey.

Discussion of things literally or figuratively unearthed in the last quarter of 2025 continues. It begins with potpourri then covers tools, Neanderthals, edibles and potables, art, shipwrecks, medical finds, and repatriations. Research: Abdallah, Hanna. “Famous Easter Island statues were created without centralized management.” PLOS. Via EurekAlert. 11/26/2025. https://www.eurekalert.org/news-releases/1106805 Abdallah, Hannah. “Early humans butchered elephants using small tools and made big tools from their bones.” PLOS. Via EurekAlert. 10/8/2025. https://www.eurekalert.org/news-releases/1100481 Abdallah, Hannah. “Researchers uncover clues to mysterious origin of famous Hjortspring boat.” EurekAlert. 10/12/2025. https://www.eurekalert.org/news-releases/1108323 Archaeology Magazine. “Medieval Hoard of Silver and Pearls Discovered in Sweden.” https://archaeology.org/news/2025/10/14/medieval-hoard-of-silver-and-pearls-discovered-in-sweden/ Archaeology Magazine. “Possible Trepanation Tool Unearthed in Poland.” 11/13/2025. https://archaeology.org/news/2025/11/13/possible-trepanation-tool-unearthed-in-poland/ Arkeologerna. “Rare 5,000-year-old dog burial unearthed in Sweden.” 12/15/2025. https://news.cision.com/se/arkeologerna/r/rare-5-000-year-old-dog-burial-unearthed-in-sweden,c4282014 Arnold, Paul. “Ancient ochre crayons from Crimea reveal Neanderthals engaged in symbolic behaviors.” Phys.org. 10/30/2025. https://phys.org/news/2025-10-ancient-ochre-crayons-crimea-reveal.html Arnold, Paul. “Dating a North American rock art tradition that lasted 175 generations.” Phys.org. 11/28/2025. https://phys.org/news/2025-11-dating-north-american-art-tradition.html Bassi, Margherita. “A Single Gene Could Have Contributed to Neanderthals’ Extinction, Study Suggests.” Smithsonian. 10/30/2025. https://www.smithsonianmag.com/smart-news/a-neanderthal-gene-variant-related-to-red-blood-cells-may-have-contributed-to-their-extinction-180987586/ Benjamin Pohl, Chewing over the Norman Conquest: the Bayeux Tapestry as monastic mealtime reading, Historical Research, 2025;, htaf029, https://doi.org/10.1093/hisres/htaf029 Benzine, Vittoria. “Decoded Hieroglyphics Reveal Female Ruler of Ancient Maya City.” ArtNet. 10/27/2025. https://news.artnet.com/art-world/foundation-stone-maya-coba-woman-ruler-2704521 Berdugo, Sophie. “Easter Island statues may have 'walked' thanks to 'pendulum dynamics' and with as few as 15 people, study finds.” LiveScience. 10/19/2025. https://www.livescience.com/archaeology/easter-island-statues-may-have-walked-thanks-to-pendulum-dynamics-and-with-as-few-as-15-people-study-finds Billing, Lotte. “Fingerprint of ancient seafarer found on Scandinavia’s oldest plank boat.” EurekAlert. 10/12/2025. https://www.eurekalert.org/news-releases/1109361 Brhel, John. “Rats played major role in Easter Island’s deforestation, study reveals.” EurekAlert. 11/17/2025. https://www.eurekalert.org/news-releases/1106361 Caldwell, Elizabeth. “9 more individuals unearthed at Oaklawn could be 1921 Tulsa Race Massacre victims.” Tulsa Public Radio. 11/6/2025. https://www.publicradiotulsa.org/local-regional/2025-11-06/9-more-individuals-unearthed-at-oaklawn-could-be-1921-tulsa-race-massacre-victims Clark, Gaby. “Bayeux Tapestry could have been originally designed as mealtime reading for medieval monks.” Phys.org. 12/15/2025. https://phys.org/news/2025-12-bayeux-tapestry-mealtime-medieval-monks.html#google_vignette Cohen, Alina. “Ancient Olive Oil Processing Complex Unearthed in Tunisia.” Artnet. 11/21/2025. https://news.artnet.com/art-world/ancient-olive-oil-complex-tunisia-2717795 Cohen, Alina. “MFA Boston Restores Ownership of Historic Works by Enslaved Artist.” ArtNet. 10/30/2025. https://news.artnet.com/art-world/mfa-boston-david-drake-jars-restitution-2706594 Fergusson, Rachel. “First DNA evidence of Black Death in Edinburgh discovered on teeth of excavated teenage skeleton.” The Scotsman. 11/5/2025. https://www.scotsman.com/news/first-dna-evidence-black-death-edinburgh-discovered-teeth-excavated-teenage-skeleton-5387741 Folorunso, Caleb et al. “MOWAA Archaeology Project: Enhancing Understanding of Benin City’s Historic Urban Development and Heritage through Pre-Construction Archaeology.” Antiquity (2025): 1–10. Web. Griffith University. “Rare stone tool cache tells story of trade and ingenuity.” 12/2/2025. https://news.griffith.edu.au/2025/12/02/rare-stone-tool-cache-tells-story-of-trade-and-ingenuity/ Han, Yu et al. “The late arrival of domestic cats in China via the Silk Road after 3,500 years of human-leopard cat commensalism.” Cell Genomics, Volume 0, Issue 0, 101099. https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00355-6 Hashemi, Sara. “A Volcanic Eruption in 1345 May Have Triggered a Chain of Events That Brought the Black Death to Europe.” Smithsonian. 12/8/2025. https://www.smithsonianmag.com/smart-news/a-volcanic-eruption-in-1345-may-have-triggered-a-chain-of-events-taht-brought-the-black-death-to-europe-180987803/ Hjortkjær, Simon Thinggaard. “Mysterious signs on Teotihuacan murals may reveal an early form of Uto-Aztecan language.” PhysOrg. 10/6/2025. https://phys.org/news/2025-10-mysterious-teotihuacan-murals-reveal-early.html Institut Pasteur. “Study suggests two unsuspected pathogens struck Napoleon's army during the retreat from Russia in 1812.” Via EurekAlert. 10/24/2025. https://www.eurekalert.org/news-releases/1102613 Jones, Sam. “Shells found in Spain could be among oldest known musical instruments.” The Guardian. 12/2/2025. https://www.theguardian.com/science/2025/dec/02/neolithic-conch-like-shell-spain-catalonia-discovery-musical-instruments Kasal, Krystal. “Pahon Cave provides a look into 5,000 years of surprisingly stable Stone Age tool use.” Phys.org. 12/16/2025. https://phys.org/news/2025-12-pahon-cave-years-stable-stone.html Kristiansen, Nina. “Eight pages bound in furry seal skin may be Norway's oldest book.” Science Norway. 11/3/2025. https://www.sciencenorway.no/cultural-history-culture-history/eight-pages-bound-in-furry-seal-skin-may-be-norways-oldest-book/2571496 Kuta, Sarah. “109-Year-Old Messages in a Bottle Written by Soldiers Heading to Fight in World War I Discovered on Australian Beach.” Smithsonian. 11/6/2025. https://www.smithsonianmag.com/smart-news/109-year-old-messages-in-a-bottle-written-by-soldiers-heading-to-fight-in-world-war-i-discovered-on-australian-beach-180987649/ Kuta, Sarah. “A Storm Battered Western Alaska, Scattering Thousands of Indigenous Artifacts Across the Sand.” Smithsonian. 10/31/2025. https://www.smithsonianmag.com/smart-news/a-storm-battered-western-alaska-scattering-thousands-of-indigenous-artifacts-across-the-sand-180987606/ Kuta, Sarah. “Archaeologists Unearth More Than 100 Projectiles From an Iconic Battlefield in Scotland.” Smithsonian. 11/5/2025. https://www.smithsonianmag.com/smart-news/archaeologists-unearth-more-than-100-projectiles-from-an-iconic-battlefield-in-scotland-180987641/ Kuta, Sarah. “Hundreds of Mysterious Victorian-Era Shoes Are Washing Up on a Beach in Wales. Nobody Knows Where They Came From.” Smithsonian. 1/5/2026. https://www.smithsonianmag.com/smart-news/hundreds-of-mysterious-victorian-era-shoes-are-washing-up-on-a-beach-in-wales-nobody-knows-where-they-came-from-180987943/ Lawson-Tancred, Jo. “Golden ‘Tudor Heart’ Necklace Sheds New Light on Henry VIII’s First Marriage.” Artnet. 10/14/2025. https://news.artnet.com/art-world/tudor-heart-pendant-british-museum-fundraiser-2699544 Lawson-Tancred, Jo. “Long-Overlooked Black Veteran Identified in Rare 19th-Century Portrait.” ArtNet. 10/27/2025. https://news.artnet.com/art-world/black-veteran-thomas-phillips-portrait-identified-2704721 Lipo CP, Hunt TL, Pakarati G, Pingel T, Simmons N, Heard K, et al. (2025) Megalithic statue (moai) production on Rapa Nui (Easter Island, Chile). PLoS One 20(11): e0336251. https://doi.org/10.1371/journal.pone.0336251 Lipo, Carl P. and Terry L. Hunt. “The walking moai hypothesis: Archaeological evidence, experimental validation, and response to critics.” Journal of Archaeological Science. Volume 183, November 2025, 106383. https://www.sciencedirect.com/science/article/abs/pii/S0305440325002328 Lock, Lisa. “Pre-construction archaeology reveals Benin City's historic urban development and heritage.” 10/29/2025. https://phys.org/news/2025-10-pre-archaeology-reveals-benin-city.html#google_vignette Lock, Lisa. “Pre-construction archaeology reveals Benin City's historic urban development and heritage.” Antiquity. Via PhysOrg. 10/29/2025. https://phys.org/news/2025-10-pre-archaeology-reveals-benin-city.html#google_vignette Lynley A. Wallis et al, An exceptional assemblage of archaeological plant fibres from Windmill Way, southeast Cape York Peninsula, Australian Archaeology (2025). DOI: 10.1080/03122417.2025.2574127 Lyon, Devyn. “Oaklawn Cemetery excavation brings investigators closer to identifying Tulsa Race Massacre victims.” Fox 23. 11/6/2025. https://www.fox23.com/news/oaklawn-cemetery-excavation-brings-investigators-closer-to-identifying-tulsa-race-massacre-victims/article_67c3a6b7-2acc-44cb-93ce-3d3d0c288eca.html Marquard, Bryan. “Bob Shumway, last known survivor of the deadly Cocoanut Grove nightclub fire, dies at 101.” 11/12/2025. https://www.bostonglobe.com/2025/11/12/metro/bob-shumway-101-dies-was-last-known-cocoanut-grove-fire-survivor/?event=event12 Marta Osypińska et al, A centurion's monkey? Companion animals for the social elite in an Egyptian port on the fringes of the Roman Empire in the 1st and 2nd c. CE, Journal of Roman Archaeology (2025). DOI: 10.1017/s1047759425100445 Merrington, Andrew. “Extensive dog diversity millennia before modern breeding practices.” University of Exeter. 11/13/2025. https://news.exeter.ac.uk/faculty-of-humanities-arts-and-social-sciences/archaeology-and-history/extensive-dog-diversity-millennia-before-modern-breeding-practices/ Morris, Steven. “Linguists start compiling first ever complete dictionary of ancient Celtic.” The Guardian. 12/8/2025. https://www.theguardian.com/science/2025/dec/08/linguists-start-compiling-first-ever-complete-dictionary-of-ancient-celtic Museum of Fine Arts, Boston. “Museum of Fine Arts, Boston, Resolves Ownership of Works by Enslaved Artist David Drake.” 10/29/2025. https://www.mfa.org/press-release/david-drake-ownership-resolution Narcity. “Niagara has a 107-year-old shipwreck lodged above the Falls and it just moved.” https://www.narcity.com/niagara-falls-shipwreck-iron-scow-moved-closer-to-the-falls Newcomb, Tim. “A 76-Year-Old Man Went On a Hike—and Stumbled Upon a 1,500-Year Old Trap.” Popular Mechanics. 11/21/2025. https://www.popularmechanics.com/science/archaeology/a69441460/reindeer-trap/ Nordin, Gunilla. “Ancient wolves on remote Baltic Sea island reveal link to prehistoric humans.” Stockholm University. Via EurekAlert. 11/24/2025. https://www.eurekalert.org/news-releases/1106807 Oster, Sandee. “DNA confirms modern Bo people are descendants of ancient Hanging Coffin culture.” Phys.org. 12/6/2025. https://phys.org/news/2025-12-dna-modern-bo-people-descendants.html Oster, Sandee. “Rare disease possibly identified in 12th century child's skeletal remains.” PhysOrg. 10/10/2025. https://phys.org/news/2025-10-rare-disease-possibly-12th-century.html Osuh, Chris and Geneva Abdul. “Lost grave of daughter of Black abolitionist Olaudah Equiano found by A-level student.” The Guardian. 11/1/2025. https://www.theguardian.com/uk-news/2025/nov/01/lost-grave-daughter-black-abolitionist-olaudah-equiano-found-by-a-level-student Silvia Albizuri et al, The oldest mule in the western Mediterranean. The case of the Early Iron Age in Hort d'en Grimau (Penedès, Barcelona, Spain), Journal of Archaeological Science: Reports (2026). DOI: 10.1016/j.jasrep.2025.105506 Skok, Phoebe. “Ancient shipwrecks rewrite the story of Iron Age trade.” PhysOrg. 10/14/2025. https://phys.org/news/2025-10-ancient-shipwrecks-rewrite-story-iron.html The History Blog. “600-year-old Joseon ship recovered from seabed.” 11/15/2025. https://www.thehistoryblog.com/archives/74652 The History Blog. “Ancient pleasure barge found off Alexandria coast.” 12/9/2025. https://www.thehistoryblog.com/archives/74860 The History Blog. “Charred Byzantine bread loves stamped with Christian imagery found in Turkey.” 10/13/2025. https://www.thehistoryblog.com/archives/74352 The History Blog. “Early medieval silver treasure found in Stockholm.” 10/12/2025. https://www.thehistoryblog.com/archives/74343 The History Blog. “Roman amphora with sardines found in Switzerland.” 12/15/2025. https://www.thehistoryblog.com/archives/74904 The Straits Times. “Wreck of ancient Malay vessel discovered on Pulau Melaka.” 10/31/2025. https://www.straitstimes.com/asia/se-asia/wreck-of-ancient-malay-vessel-discovered-on-pulau-melaka Thompson, Sarah. “The forgotten daughter: Eliza Monroe Hay’s story revealed in her last letters.” W&M News. 9/30/2025. https://news.wm.edu/2025/09/30/the-forgotten-daughter-eliza-monroes-story-revealed-in-her-last-letters/ Tuhkuri, Jukka. “Why Did Endurance Sink?” Polar Record 61 (2025): e23. Web. https://www.cambridge.org/core/journals/polar-record/article/why-did-endurance-sink/6CC2C2D56087035A94DEB50930B81980 Universitat de Valencia. “The victims of the Pompeii eruption wore heavy wool cloaks and tunics, suggesting different environmental conditions in summer.” 12/3/2025. https://www.uv.es/uvweb/uv-news/en/news/victims-pompeii-eruption-wore-heavy-wool-cloaks-tunics-suggesting-different-environmental-conditions-summer-1285973304159/Novetat.html?id=1286464337848&plantilla=UV_Noticies/Page/TPGDetaillNews University of Glasgow. “Archaeologists recover hundreds of Jacobite projectiles in unexplored area of Culloden.” 10/30/2025. https://www.gla.ac.uk/news/headline_1222736_en.html University of Vienna. “Neanderthal DNA reveals ancient long-distance migrations.” 10/29/2025. https://www.univie.ac.at/en/news/detail/neanderthal-dna-reveals-ancient-long-distance-migrations Zhou, H., Tao, L., Zhao, Y. et al. Exploration of hanging coffin customs and the bo people in China through comparative genomics. Nat Commun 16, 10230 (2025). https://doi.org/10.1038/s41467-025-65264-3 Zinin, Andrew. “Ancient humans mastered fire-making 400,000 years ago, study shows.” Phys.org. 10/10/2025. https://phys.org/news/2025-12-ancient-humans-mastered-years.html See omnystudio.com/listener for privacy information.

(0:00) Steelers start coaching search – who are the top candidates?(14:30) Steve Bisciotti's first press conference following John Harbaugh's firing(22:00) Bisciotti on decision to fire Harbaugh(26:00) How much say will Lamar Jackson have in coaching search?(32:00) Bisciotti on contract extension for Lamar(36:00) Early look at Rams-Bears(39:00) QB to lead your two-minute drive: Stafford or Williams?(42:00) Matt LaFleur responds to Aaron Rodgers' postgame comments(47:00) Kevin Patullo out as Eagles OC(49:30) Chargers fire OC Greg Roman Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Happy New Year! Four morons are back for the first "Wins & Wiffs" episode of 2026 (Ep. 184 of FITT) to talk about the incredible toy pickups kicking off the new year—and one member is suspiciously missing!This week's Wins are all about big finds and bigger deals:• A great score on a new collectible from Star Wars.• Finally completing a difficult hunt for classic 80s TV show action figures.• The Deal of the Year contender: Getting multiple, premium high-end vehicle collectibles for a ridiculously low price after a store clearance!• Starting a costly, high-stakes journey collecting retired, valuable fantasy building sets from a decade ago.Which toy haul was the biggest W? Let us know in the comments!0:00 Intro & Chris is Missing3:50 Win of the Week: First Pick4:51 Funko Pop Star Wars Bobblehead7:26 1983 Galoob A-Team Action Figures12:37 Super7 Batman Super Cyborg Batmobile 1989 Vehicle Store Display14:32 Super7 Batman Super Cyborg Batmobile Tumbler Store Display18:07 Retired 2012 LEGO The Lord of the Rings 9469 Gandalf Arrives Set22:23 Outro#toycollector #Batmobile #lotrlego #Super7 #tumbler #supercyborg #lordoftherings #ateam #vintagetoys #thefellowshipofthering #toydeals #collectibles #toyhaul #funkopops #lego #funko #actionfigures #podcast #toytalk #batman #lotr #rarelego #funkopop #galoob #mrt #gandalf #froto #batmobile1989 #lego2012 #legominifigures #lego9469-----------------------

The King of Collectibles Ken Goldin joins the boys to discuss selling Logan Paul's Pokémon card for OVER $12.6M (Pikachu Illustrator), does a box break LIVE, why he sold a bible to Kim Kardashian, laughs at Logan for losing a bidding war to Drake, personally buying a card for $20 MILLION, Shohei Ohtani's ULTRA-RARE Home-Run ball, the rarest 3 cards of ALL-TIME & more…SUBSCRIBE TO THE PODCAST ► https://www.youtube.com/impaulsiveFanatics ONE members earn FanCash and everything that comes with it like gear, tickets, bonus bets, collectibles and more. Join on the Fanatics App and enjoy other member benefit like Free Shipping and Returns and Exclusive Access to Product. https://apps.apple.com/us/app/fanatics-shop-nfl-nba-mlb/id712661687Meet your favorite athletes and WWE Superstars, get your hands on exclusive merch, catch live podcasts and interact with the biggest names in sports. Tickets go on sale this November, so mark your calendars and don't miss out. Full information at https://www.fanaticsfest.com/Thank you Content HQ for hosting us! https://www.instagram.com/contenthqmiami?igsh=Y3A2MWZvOG54M2o0Watch Previous (Kai Trump on Donald Trump's 3rd Term, Dating with 24/7 Secret Service, Golfing w/ the President: 488) ► https://www.youtube.com/watch?v=prQ7Mw_YPEEADD US ON:INSTAGRAM: https://www.instagram.com/impaulsiveshow/Timestamps:0:00 Welcome Ken Goldin!

Every year, police in the United States kill over a thousand people. In the United Kingdom and much of Europe, the number is often in the single digits — sometimes zero. Drawing on recent data, legal standards, and the killing of Renee Nicole Good in Minneapolis, this essay examines how American policing has come to normalize lethal force, how guns and unregulated training shape officer behavior, and why accountability for police violence is almost nonexistent. It also confronts the racial reality of policing in the U.S., where Black Americans are killed at far higher rates, often following racial profiling and routine traffic stops. This is not about “a few bad apples.” It's about policy choices: armed patrols, permissive use-of-force standards, political immunity, and a culture that prioritizes state power over human life. Other democracies have shown that policing without routine killing is possible. The United States has chosen a different path. Independent media has never been more important. Please support this channel by subscribing here: https://www.youtube.com/channel/UCkbwLFZhawBqK2b9gW08z3g?sub_confirmation=1 Join this channel with a membership for exclusive early access and bonus content: https://www.youtube.com/channel/UCkbwLFZhawBqK2b9gW08z3g/join Buy Anthony's microphone: https://kellards.com/products/electro-voice-re20-broadcast-announcer-microphone-black-bundle-with-mic-shockmount-broadcast-arm Buy Anthony's black t'shirt: https://www.uniqlo.com/us/en/products/E455365-000/00?colorDisplayCode=09 Five Minute News is an Evergreen Podcast, covering politics, inequality, health and climate - delivering independent, unbiased and essential news for the US and across the world. Visit us online at http://www.fiveminute.news Follow us on Bluesky https://bsky.app/profile/fiveminutenews.bsky.social Follow us on Instagram http://instagram.com/fiveminnews Support us on Patreon http://www.patreon.com/fiveminutenews You can subscribe to Five Minute News with your preferred podcast app, ask your smart speaker, or enable Five Minute News as your Amazon Alexa Flash Briefing skill. CONTENT DISCLAIMER The views and opinions expressed on this channel are those of the guests and authors and do not necessarily reflect the official policy or position of Anthony Davis or Five Minute News LLC. Any content provided by our hosts, guests or authors are of their opinion and are not intended to malign any religion, ethnic group, club, organization, company, individual or anyone or anything, in line with the First Amendment right to free and protected speech. Learn more about your ad choices. Visit megaphone.fm/adchoices

God help us all. Chicago’s best morning radio show now has a podcast! Don’t forget to rate, review, and subscribe wherever you listen to podcasts and remember that the conversation always lives on the Q101 Facebook page. Brian & Kenzie are live every morning from 6a-10a on Q101. Subscribe to our channel HERE: https://www.youtube.com/@Q101 Like Q101 on Facebook HERE: https://www.facebook.com/q101chicago Follow Q101 on Twitter HERE: https://twitter.com/Q101Chicago Follow Q101 on Instagram HERE: https://www.instagram.com/q101chicago/?hl=en Follow Q101 on TikTok HERE: https://www.tiktok.com/@q101chicago?lang=enSee omnystudio.com/listener for privacy information.

Melanie Hahnemann has been judged for generations — especially after Hahnemann's death.In Episode 105, we revisit the romance, the rumors, and the real historical stakes behind her legacy — including the moment that complicates the easy labels: what Hahnemann asked of her, and what came next.Strange, Rare & Peculiar is a weekly podcast with Denise Straiges and Alastair Gray of the Institute for the Advancement of Homeopathy and the Academy of Homeopathy Education.This season, we're focusing on truth — what it means to Aude Sapere (“dare to know”) in homeopathy today. From Hahnemann's original insights to the realities of modern practice, research, and education, Denise and Alastair bring over 50 years of experience to conversations that challenge assumptions and invite curiosity.

A rare copy of the comic book that introduced the world to Superman and also was once stolen from the home of actor Nicolas Cage has been sold for a record $15 million. As the network and Dick Clark Productions threw everything against the wall in the hopes of finding something sticky to snare viewership. Many viewers of Sunday’s Golden Globes were left irate as the award show displayed Polymarket odds on potential winners throughout the night. Please Like, Comment and Follow 'Philip Teresi on KMJ' on all platforms: --- Philip Teresi on KMJ is available on the KMJNOW app, Apple Podcasts, Spotify, YouTube or wherever else you listen to podcasts. -- Philip Teresi on KMJ Weekdays 2-6 PM Pacific on News/Talk 580 AM & 105.9 FM KMJ | Website | Facebook | Instagram | X | Podcast | Amazon | - Everything KMJ KMJNOW App | Podcasts | Facebook | X | Instagram See omnystudio.com/listener for privacy information.

När jag hörde av mig till Skolverket och sa att jag tappat förtroendet för dem svarade de att jag borde tänka över mitt yrkesval. Eftersom de uppenbarligen skiter i mig och mina kollegor är frågan: Vem ska vi lärare vända oss till? Det undrar veckans brevskrivare. Läs här vad Anna-Karin Wyndhamn svarar honom. Inläsare: Staffan Dopping

The show's coverage of things literally or figuratively unearthed in the last quarter of 2025 begins with updates, books and letters, animals, and just one exhumation. Research: Abdallah, Hanna. “Famous Easter Island statues were created without centralized management.” PLOS. Via EurekAlert. 11/26/2025. https://www.eurekalert.org/news-releases/1106805 Abdallah, Hannah. “Early humans butchered elephants using small tools and made big tools from their bones.” PLOS. Via EurekAlert. 10/8/2025. https://www.eurekalert.org/news-releases/1100481 Abdallah, Hannah. “Researchers uncover clues to mysterious origin of famous Hjortspring boat.” EurekAlert. 10/12/2025. https://www.eurekalert.org/news-releases/1108323 Archaeology Magazine. “Medieval Hoard of Silver and Pearls Discovered in Sweden.” https://archaeology.org/news/2025/10/14/medieval-hoard-of-silver-and-pearls-discovered-in-sweden/ Archaeology Magazine. “Possible Trepanation Tool Unearthed in Poland.” 11/13/2025. https://archaeology.org/news/2025/11/13/possible-trepanation-tool-unearthed-in-poland/ “Rare 5,000-year-old dog burial unearthed in Sweden.” 12/15/2025. https://news.cision.com/se/arkeologerna/r/rare-5-000-year-old-dog-burial-unearthed-in-sweden,c4282014 Arnold, Paul. “Ancient ochre crayons from Crimea reveal Neanderthals engaged in symbolic behaviors.” Phys.org. 10/30/2025. https://phys.org/news/2025-10-ancient-ochre-crayons-crimea-reveal.html Arnold, Paul. “Dating a North American rock art tradition that lasted 175 generations.” Phys.org. 11/28/2025. https://phys.org/news/2025-11-dating-north-american-art-tradition.html Bassi, Margherita. “A Single Gene Could Have Contributed to Neanderthals’ Extinction, Study Suggests.” Smithsonian. 10/30/2025. https://www.smithsonianmag.com/smart-news/a-neanderthal-gene-variant-related-to-red-blood-cells-may-have-contributed-to-their-extinction-180987586/ Benjamin Pohl, Chewing over the Norman Conquest: the Bayeux Tapestry as monastic mealtime reading, Historical Research, 2025;, htaf029, https://doi.org/10.1093/hisres/htaf029 Benzine, Vittoria. “Decoded Hieroglyphics Reveal Female Ruler of Ancient Maya City.” ArtNet. 10/27/2025. https://news.artnet.com/art-world/foundation-stone-maya-coba-woman-ruler-2704521 Berdugo, Sophie. “Easter Island statues may have 'walked' thanks to 'pendulum dynamics' and with as few as 15 people, study finds.” LiveScience. 10/19/2025. https://www.livescience.com/archaeology/easter-island-statues-may-have-walked-thanks-to-pendulum-dynamics-and-with-as-few-as-15-people-study-finds Billing, Lotte. “Fingerprint of ancient seafarer found on Scandinavia’s oldest plank boat.” EurekAlert. 10/12/2025. https://www.eurekalert.org/news-releases/1109361 Brhel, John. “Rats played major role in Easter Island’s deforestation, study reveals.” EurekAlert. 11/17/2025. https://www.eurekalert.org/news-releases/1106361 Caldwell, Elizabeth. “9 more individuals unearthed at Oaklawn could be 1921 Tulsa Race Massacre victims.” Tulsa Public Radio. 11/6/2025. https://www.publicradiotulsa.org/local-regional/2025-11-06/9-more-individuals-unearthed-at-oaklawn-could-be-1921-tulsa-race-massacre-victims Clark, Gaby. “Bayeux Tapestry could have been originally designed as mealtime reading for medieval monks.” Phys.org. 12/15/2025. https://phys.org/news/2025-12-bayeux-tapestry-mealtime-medieval-monks.html#google_vignette Cohen, Alina. “Ancient Olive Oil Processing Complex Unearthed in Tunisia.” Artnet. 11/21/2025. https://news.artnet.com/art-world/ancient-olive-oil-complex-tunisia-2717795 Cohen, Alina. “MFA Boston Restores Ownership of Historic Works by Enslaved Artist.” ArtNet. 10/30/2025. https://news.artnet.com/art-world/mfa-boston-david-drake-jars-restitution-2706594 Fergusson, Rachel. “First DNA evidence of Black Death in Edinburgh discovered on teeth of excavated teenage skeleton.” The Scotsman. 11/5/2025. https://www.scotsman.com/news/first-dna-evidence-black-death-edinburgh-discovered-teeth-excavated-teenage-skeleton-5387741 Folorunso, Caleb et al. “MOWAA Archaeology Project: Enhancing Understanding of Benin City’s Historic Urban Development and Heritage through Pre-Construction Archaeology.” Antiquity (2025): 1–10. Web. Griffith University. “Rare stone tool cache tells story of trade and ingenuity.” 12/2/2025. https://news.griffith.edu.au/2025/12/02/rare-stone-tool-cache-tells-story-of-trade-and-ingenuity/ Han, Yu et al. “The late arrival of domestic cats in China via the Silk Road after 3,500 years of human-leopard cat commensalism.” Cell Genomics, Volume 0, Issue 0, 101099. https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00355-6 Hashemi, Sara. “A Volcanic Eruption in 1345 May Have Triggered a Chain of Events That Brought the Black Death to Europe.” Smithsonian. 12/8/2025. https://www.smithsonianmag.com/smart-news/a-volcanic-eruption-in-1345-may-have-triggered-a-chain-of-events-taht-brought-the-black-death-to-europe-180987803/ Hjortkjær, Simon Thinggaard. “Mysterious signs on Teotihuacan murals may reveal an early form of Uto-Aztecan language.” PhysOrg. 10/6/2025. https://phys.org/news/2025-10-mysterious-teotihuacan-murals-reveal-early.html Institut Pasteur. “Study suggests two unsuspected pathogens struck Napoleon's army during the retreat from Russia in 1812.” Via EurekAlert. 10/24/2025. https://www.eurekalert.org/news-releases/1102613 Jones, Sam. “Shells found in Spain could be among oldest known musical instruments.” The Guardian. 12/2/2025. https://www.theguardian.com/science/2025/dec/02/neolithic-conch-like-shell-spain-catalonia-discovery-musical-instruments Kasal, Krystal. “Pahon Cave provides a look into 5,000 years of surprisingly stable Stone Age tool use.” Phys.org. 12/16/2025. https://phys.org/news/2025-12-pahon-cave-years-stable-stone.html Kristiansen, Nina. “Eight pages bound in furry seal skin may be Norway's oldest book.” Science Norway. 11/3/2025. https://www.sciencenorway.no/cultural-history-culture-history/eight-pages-bound-in-furry-seal-skin-may-be-norways-oldest-book/2571496 Kuta, Sarah. “109-Year-Old Messages in a Bottle Written by Soldiers Heading to Fight in World War I Discovered on Australian Beach.” Smithsonian. 11/6/2025. https://www.smithsonianmag.com/smart-news/109-year-old-messages-in-a-bottle-written-by-soldiers-heading-to-fight-in-world-war-i-discovered-on-australian-beach-180987649/ Kuta, Sarah. “A Storm Battered Western Alaska, Scattering Thousands of Indigenous Artifacts Across the Sand.” Smithsonian. 10/31/2025. https://www.smithsonianmag.com/smart-news/a-storm-battered-western-alaska-scattering-thousands-of-indigenous-artifacts-across-the-sand-180987606/ Kuta, Sarah. “Archaeologists Unearth More Than 100 Projectiles From an Iconic Battlefield in Scotland.” Smithsonian. 11/5/2025. https://www.smithsonianmag.com/smart-news/archaeologists-unearth-more-than-100-projectiles-from-an-iconic-battlefield-in-scotland-180987641/ Kuta, Sarah. “Hundreds of Mysterious Victorian-Era Shoes Are Washing Up on a Beach in Wales. Nobody Knows Where They Came From.” Smithsonian. 1/5/2026. https://www.smithsonianmag.com/smart-news/hundreds-of-mysterious-victorian-era-shoes-are-washing-up-on-a-beach-in-wales-nobody-knows-where-they-came-from-180987943/ Lawson-Tancred, Jo. “Golden ‘Tudor Heart’ Necklace Sheds New Light on Henry VIII’s First Marriage.” Artnet. 10/14/2025. https://news.artnet.com/art-world/tudor-heart-pendant-british-museum-fundraiser-2699544 Lawson-Tancred, Jo. “Long-Overlooked Black Veteran Identified in Rare 19th-Century Portrait.” ArtNet. 10/27/2025. https://news.artnet.com/art-world/black-veteran-thomas-phillips-portrait-identified-2704721 Lipo CP, Hunt TL, Pakarati G, Pingel T, Simmons N, Heard K, et al. (2025) Megalithic statue (moai) production on Rapa Nui (Easter Island, Chile). PLoS One 20(11): e0336251. https://doi.org/10.1371/journal.pone.0336251 Lipo, Carl P. and Terry L. Hunt. “The walking moai hypothesis: Archaeological evidence, experimental validation, and response to critics.” Journal of Archaeological Science. Volume 183, November 2025, 106383. https://www.sciencedirect.com/science/article/abs/pii/S0305440325002328 Lock, Lisa. “Pre-construction archaeology reveals Benin City's historic urban development and heritage.” 10/29/2025. https://phys.org/news/2025-10-pre-archaeology-reveals-benin-city.html#google_vignette Lock, Lisa. “Pre-construction archaeology reveals Benin City's historic urban development and heritage.” Antiquity. Via PhysOrg. 10/29/2025. https://phys.org/news/2025-10-pre-archaeology-reveals-benin-city.html#google_vignette Lynley A. Wallis et al, An exceptional assemblage of archaeological plant fibres from Windmill Way, southeast Cape York Peninsula, Australian Archaeology (2025). DOI: 10.1080/03122417.2025.2574127 Lyon, Devyn. “Oaklawn Cemetery excavation brings investigators closer to identifying Tulsa Race Massacre victims.” Fox 23. 11/6/2025. https://www.fox23.com/news/oaklawn-cemetery-excavation-brings-investigators-closer-to-identifying-tulsa-race-massacre-victims/article_67c3a6b7-2acc-44cb-93ce-3d3d0c288eca.html Marquard, Bryan. “Bob Shumway, last known survivor of the deadly Cocoanut Grove nightclub fire, dies at 101.” 11/12/2025. https://www.bostonglobe.com/2025/11/12/metro/bob-shumway-101-dies-was-last-known-cocoanut-grove-fire-survivor/?event=event12 Marta Osypińska et al, A centurion's monkey? Companion animals for the social elite in an Egyptian port on the fringes of the Roman Empire in the 1st and 2nd c. CE, Journal of Roman Archaeology (2025). DOI: 10.1017/s1047759425100445 Merrington, Andrew. “Extensive dog diversity millennia before modern breeding practices.” University of Exeter. 11/13/2025. https://news.exeter.ac.uk/faculty-of-humanities-arts-and-social-sciences/archaeology-and-history/extensive-dog-diversity-millennia-before-modern-breeding-practices/ Morris, Steven. “Linguists start compiling first ever complete dictionary of ancient Celtic.” The Guardian. 12/8/2025. https://www.theguardian.com/science/2025/dec/08/linguists-start-compiling-first-ever-complete-dictionary-of-ancient-celtic Museum of Fine Arts, Boston. “Museum of Fine Arts, Boston, Resolves Ownership of Works by Enslaved Artist David Drake.” 10/29/2025. https://www.mfa.org/press-release/david-drake-ownership-resolution “Niagara has a 107-year-old shipwreck lodged above the Falls and it just moved.” https://www.narcity.com/niagara-falls-shipwreck-iron-scow-moved-closer-to-the-falls Newcomb, Tim. “A 76-Year-Old Man Went On a Hike—and Stumbled Upon a 1,500-Year Old Trap.” Popular Mechanics. 11/21/2025. https://www.popularmechanics.com/science/archaeology/a69441460/reindeer-trap/ Nordin, Gunilla. “Ancient wolves on remote Baltic Sea island reveal link to prehistoric humans.” Stockholm University. Via EurekAlert. 11/24/2025. https://www.eurekalert.org/news-releases/1106807 Oster, Sandee. “DNA confirms modern Bo people are descendants of ancient Hanging Coffin culture.” Phys.org. 12/6/2025. https://phys.org/news/2025-12-dna-modern-bo-people-descendants.html Oster, Sandee. “Rare disease possibly identified in 12th century child's skeletal remains.” PhysOrg. 10/10/2025. https://phys.org/news/2025-10-rare-disease-possibly-12th-century.html Osuh, Chris and Geneva Abdul. “Lost grave of daughter of Black abolitionist Olaudah Equiano found by A-level student.” The Guardian. 11/1/2025. https://www.theguardian.com/uk-news/2025/nov/01/lost-grave-daughter-black-abolitionist-olaudah-equiano-found-by-a-level-student Silvia Albizuri et al, The oldest mule in the western Mediterranean. The case of the Early Iron Age in Hort d'en Grimau (Penedès, Barcelona, Spain), Journal of Archaeological Science: Reports (2026). 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Leadership is already messy. Add culture, identity, power dynamics, and a workplace that rewards sameness… and suddenly you're not leading—you're surviving. In this episode, Nicole talks with Aiko Bethea, founder of RARE Coaching & Consulting, about what actually creates diversity (spoiler: it's not a checkbox) and why diversity is the outcome of great leadership. We get into: Why “diversity” isn't a skill set (and why treating it like one makes you a worse leader) Power-sharing vs. power-hoarding and how that impacts belonging, equity, and performance The real reason leadership advice feels like a chaotic buffet of contradictions How to measure leadership impact beyond “we hit the number” (because people aren't spreadsheets) Why leaders making mistakes feels riskier than ever—and why ownership is still the right move The “punching a ghost” feeling when reality is being rewritten in real time  What it means to be a well leader: aligned, accountable, humane—not perfect Because the goal isn't to lead like the “stereotypical old-school leader.” The goal is to lead like your full self—and create workplaces where more people can do the same. Thank you to our sponsors! Get 20% off your first order at curehydration.com/WOMANSWORK with code WOMANSWORK — and if you get a post-purchase survey, mention you heard about Cure here to help support the show!  Sex is a skill. Beducated is where you learn it. Visit https://beducate.me/pd2550-womanswork and use code womanswork for 50% off the annual pass. Connect with Aiko: Website: https://www.rarecoaching.net/  IG: https://www.instagram.com/rare_coach  Invite to join RARE community  -  https://www.rarecoaching.net/membership/ Related Podcast Episodes: Leadership Unblocked (The Hidden Beliefs Sabotaging Your Ability To Lead) with Muriel M. Wilkins | 367  How to Push Back: From People-Pleasing to Power with Tonya Lester | 369 How To Be Yourself At Work: Authentic Presence Over Executive Presence with Claude Silver | 366 Share the Love: If you found this episode insightful, please share it with a friend, tag us on social media, and leave a review on your favorite podcast platform!

Our guest this week not only voiced Donkey Kong in Donkey Kong 64 and many other games, but he created the classic music for Goldeneye 007, Donkey Kong 64, Perfect Dark, Banjo-Kazooie, and many other memorable games! Award-winning composer and voice actor Grant Kirkhope stops by to share stories behind gaming classics like Banjo-Kazooie, the DK Rap from Donkey Kong 64, and even GoldenEye 64's iconic music. From his early musical influences to his legendary work at Rare, Grant dives into the tunes that shaped childhoods and pop culture. He also spills secrets about his time working on Perfect Dark, Viva Pinata, and other gaming masterpieces, plus he shares experiences touring with rock icons like Eddie Van Halen and Bon Jovi. This episode is a must listen! GrantKirkhope.com Instagram: @GrantKirkhopeComposer CannedAirPodcast.com TikTok: @CannedAirPodcast Instagram: @Canned_Air If you'd like to show your support, you can either visit our Patreon page at Patreon.com/CannedAirPod or you can leave us a comment, like, and subscribe! Thanks for watching! #goldeneyen64 #goldeneye007 #nintendo #raregames #donkeykong #dkrap #perfectdark #banjokazooie #mario #podcast #video #vlog   Learn more about your ad choices. Visit megaphone.fm/adchoices

The All Local evening update for Monday January 12, 2026

Dr. Hope Rugo and Dr. Vivek Subbiah discuss innovative trial designs to enable robust studies for smaller patient populations, as well as the promise of precision medicine, novel therapeutic approaches, and global partnerships to advance rare cancer research and improve patient outcomes. TRANSCRIPT  Dr. Hope Rugo: Hello and welcome to By the Book, a podcast series from ASCO that features engaging conversations between editors and authors of the ASCO Educational Book. I am your host, Dr. Hope Rugo. I am the director of the Women's Cancers Program and division chief of breast medical oncology at the City of Hope Cancer Center [in Los Angeles]. The field of rare cancer research is rapidly transforming thanks to progress in clinical trials and treatment strategies, as well as improvements in precision medicine and next-generation sequencing that enable biomarker identification. According to the National Cancer Institute, rare cancers occur in fewer than 150 cases per million each year, but collectively, they represent a significant portion of all cancer diagnoses. And we struggle with the appropriate treatment for these rare cancers in clinical practice. Today, I am delighted to be joined by Dr. Vivek Subbiah, a medical oncologist and the chief of early-phase drug development at the Sarah Cannon Research Institute in Nashville, Tennessee. Dr. Subbiah is the lead author of a paper in the ASCO Educational Book titled "Designing Clinical Trials for Patients with Rare Cancers: Connecting the Zebras," a great title for this topic. He will be telling us about innovative trial designs to enable robust studies for small patient populations, the promise of precision medicine, and novel therapeutic approaches to improve outcomes, and how we can leverage AI now to enroll more patients with rare cancers in clinical trials. Our full disclosures are available in the transcript of this episode.  Dr. Subbiah, it is great to have you on the podcast today. Thanks so much for being here. Dr. Vivek Subbiah: Thank you so much, Dr. Rugo, and it is an honor and pleasure being here. And thank you for doing this podcast for rare cancers. Dr. Hope Rugo: Absolutely. We are excited to talk to you. And congratulations on this fantastic paper. It is such a great resource for our community to better understand what is new in the field of rare cancer research. Of course, rare cancers are complex and multifaceted diseases. And this is a huge challenge for clinical oncologists. You know, our clinics, of course, cannot be designed as we are being very uni-cancer focused to just be for one cancer that is very rare. So, oncologists have to be a jack of all trades in this area. Your paper notes that there are approximately 200 distinct types of rare and ultra-rare cancers. And, by definition, all pediatric cancers are rare cancers. Of course, clinical trials are essential for developing new treatment strategies and improving patient outcomes, and in your paper, you highlight some unique challenges in conducting trials in this rare cancer space. Can you tell us about the challenges and how really innovative trial designs, I think a key issue, are being tailored to the specific needs of patients with rare cancer and, importantly, for these trials? Dr. Vivek Subbiah: Rare cancers present a perfect storm of challenges. First, the patient populations are very small, which makes it really hard to recruit enough participants for traditional type trials. Second, these patients are often geographically dispersed across multiple cities, across multiple states, across multiple countries, across multiple zip codes. So, logistics become complicated. Third, there is often limited awareness among clinicians, which delays referrals and diagnosis. Add to that regulatory hurdles, funding constraints, and you can see why rare cancer trials are so tough to execute. To overcome these barriers, we are seeing some really creative novel trial designs. And there are four different types of trial designs that are helping with enrolling patients with rare cancers. The first one is the basket trial. So let us talk about what basket studies are. Basket studies group patients based on shared genetic biomarkers or shared genetic mutations rather than tumor type. So instead of running separate 20 to 30 to 40 trials, you can study one therapy across multiple cancers. The second type of trial is the umbrella trial. The umbrella trials flip that concept of basket studies. They focus on one cancer type but test multiple targeted therapies within it. The third category of innovative trials are the platform studies. Platform trials are another exciting innovation. They allow new treatment arms to be added or removed as the data matures and as the data evolves, making trials more adaptive and efficient. The final category are decentralized tools in traditional trials, which are helping patients participate closer to where they are so that they can sleep in their own bed, which is, I think, a game changer for accessibility.  These designs maximize efficiency and feasibility for rare cancer research and rare cancer clinical trials. Dr. Hope Rugo: I love the idea of the platform trials that are decentralized. And I know that there is a trial being worked on with ARPA-H (Advanced Research Projects Agency for Health) funding in triple-negative breast cancer as well as in lung cancer, I think, and others with this idea of a platform trial. But it is challenged, I think, by precision medicine and next-generation sequencing where some patients do not have targetable markers, or there isn't a drug to target the marker. I think those are almost the same thing. We have really seen that these precision medicine ideas and NGS have moved the needle in helping to identify genetic alterations. This helps us to be more personalized. It actually helps with platform studies to customize trial enrollment. And we hope that this will result in better outcomes. It also allows us, I think, to study drugs even in the early stage setting more effectively. How can these advances be best applied to the future of rare cancers, as well as the challenges of not finding a marker or not having a drug? Dr. Vivek Subbiah: Thank you so much for that question. I think precision medicine and next-gen sequencing, or NGS, are truly the backbone of modern precision oncology. They have transformed how we think about cancer treatment. Instead of treating based on where the tumor originated or where the tumor started, we now look at the genetic blueprint of cancer. The NGS or next-gen sequencing allows us to sequence millions of DNA fragments quickly. Twenty, 30 years ago, they said we cannot sequence a human genome. Then it took almost a decade to sequence the first human genome. Right now, we have academic centers and commercial sequencing companies that are really democratizing NGS across all sites, not just in academic centers, across all the community sites, so that NGS is now accessible. This means that we can identify these actionable alterations like picking needles in haystacks, like NTRK fusions, RET fusions, or BRAF V600E alterations, high tumor mutational burden. This might occur across not one tumor type, across several different tumor types. So for rare cancers, this is critical because some of these mutations often define the best treatment option. Here is why this matters. Personalized therapy, right? Instead of a one-size-fits-all approach, we can tailor treatment to the patient's unique molecular profile. For trial enrollment, this can definitely help because patients can join biomarker-driven trials even if their cancer type is rare or ultra-rare. NGS technology has also helped us in designing rational studies. Many times monotherapy does not work in these cancers. So we are thinking about rational combination strategies. So NGS technology is helping us. Looking ahead, I see NGS becoming routine in clinical practice, not just at major niche academic centers, but everywhere. We will see more tumor-agnostic approvals, more molecular tumor boards guiding treatment decisions in real time. And I think we are seeing an expanded biomarker setup. Previously, we used to have only a few drugs and a handful of mutations. Now with homologous recombination defects, BRCA1/2 mutation, and expanding the HRD and also immunohistochemistry, we are expanding the biomarker portfolio. So again, I personally believe that the future is precision. What I mean by precision is delivering the right drug to the right patient at the right time. And for rare cancers, this isn't just progress. It is survival. And it is maybe the only way that they can have access to these cutting-edge precision medicines. Dr. Hope Rugo: That is so important. You mentioned an important area we will get to in a moment, the tumor-agnostic therapies. But as part of talking about that, do you think that the trials should also include just standard therapies? You know, who do you give an ADC to and when with these rare cancers? Because some of them do not have biomarkers to target and it is so disappointing for patients and providers where you are trying to screen a patient for a trial or a platform trial where you have one arm with this mutation, one arm with that, and they do not qualify because they only have a p53 loss, you know? They just do not have the marker that helps them. But we see this in breast cancer all the time. And it is tough because we don't have good information on the sequencing. So I wonder, you know, just because for some of these rare cancers it is not even clear what to use when with standard treatments. And then that kind of gets into this idea of the tumor-agnostic therapies that you mentioned. There are a lot of new treatments that are being evaluated. We have seen approval of some treatments in the last few years that are tumor-agnostic and based on a biomarker. Is that the best approach as we go forward for rare cancers? And what new treatment options are most exciting to you right now? Dr. Vivek Subbiah: Tumor-agnostic therapies, really close to my heart, are real breakthrough therapies and represent a major paradigm shift in oncology. Traditionally, for the broad listeners here, we are used to thinking about designing clinical trials and therapy like where the cancer originated, breast cancer, kidney cancer, prostate cancer, lung cancer. A tumor-agnostic therapy flips that model. Instead of focusing on the organ, they target the specific genetic alteration or biomarker that drives cancer growth regardless of where the tumor started, regardless of the location of the tumor, regardless of the zip code of the tumor. So why is this so important for rare cancers? Because many rare cancers share molecular features with more common cancers. For instance, NTRK fusion might occur in pediatric sarcoma, a salivary gland tumor, or a thyroid cancer. Historically, each of these would require separate trials, which is nearly impossible, unfeasible to conduct in these ultra-rare cancers like salivary gland cancer or pediatric sarcomas. Tumor-agnostic therapies allow us to treat all those cancers with the same targeted drug if they share that biomarker. Again, we are in 2025. The first tissue-agnostic approval, the historic precedent, was in fact an immunotherapy. Pembrolizumab was approved in 2017, May 2017, as the first immunotherapy to be approved in a tumor-agnostic way for a genomic biomarker, for MSI-High and dMMR cancers. Then came the NTRK inhibitors. So today we have not one, not two, but three different NTRK inhibitors: larotrectinib, entrectinib, and repotrectinib, which show response rates of nearly more than 60 to 75% across a handful of dozens and dozens of cancer types. Then, of course, we have RET inhibitors like selpercatinib, which is approved tissue-agnostic, and pralsetinib, which also shows tissue-agnostic activity across multiple cancers. And more recently, combination therapy with a BRAF and MEK combination, dabrafenib and trametinib, received tumor-agnostic approval for all BRAF V600E tumors with the exception of colorectal cancer. And even recently, you mentioned about antibody drug conjugates. Again, I think we live in an era of antibody drug conjugates. And Enhertu, trastuzumab deruxtecan, which was used first in breast cancer, now it is approved in a histology-agnostic manner for all HER2-positive tumors defined by immunohistochemistry 3+. So again, beyond NGS, now immunohistochemistry for HER2 is also becoming a biomarker. So again, for the broad listeners here, in addition to comprehensive NGS that may allow patients to find treatment options for these rare cancers for NTRK, RET, and BRAF, immunohistochemistry for HER2 positivity is also emerging as a biomarker given that we have a new FDA approval for this. So I would say personally that these therapies are game changers because they open doors for patients who previously had no options. Instead of waiting for years for a trial in their specific cancer type, they can access a treatment based on their molecular profile. I think it is precision medicine at its finest and best. Looking ahead, the third question you asked me is what is exciting going on? I think we will see more of these approvals. My hope is that today, I think we have nine to ten approvals. My hope is that within the next 25 to 50 years, we will have at least 50 to 100 drugs approved in this space based on a biomarker, not based on a location of the tumor type. Drug targeting rare alterations like FGFR2 fusions, FGFR amplifications, ALK fusions, and even complex signatures like high tumor mutational burden. I think we will be seeing hopefully more and more drugs approved. And as sequencing becomes routine, we will identify more patients for these therapies. I think for rare cancers, this is not just innovative approach. This is essential for them to access these novel precision medicines. Dr. Hope Rugo: Yeah, that is such a good point. I do think it is critical. Interestingly in breast cancer, it hasn't been, you know, there is always like two patients in these tumor-agnostic trials, or if that. You know, I think I have seen one NTRK fusion ever. I think that highlights the importance for rare cancers. And you know, I am hoping that that will translate into some new directions for some of our rarer and impossible-to-treat subtypes of breast cancer. It is this kind of research that is really going to make a difference. But what about those people who do not have biomarkers? What if you do not fit into that? Do you think there is a possibility of trying to do treatments for rare cancers in some prospective way that would help with that? You know, it is really a huge challenge. Dr. Vivek Subbiah: Absolutely. I think, you know, you're right, usually many of these rare cancers are driven by specific biomarkers. And again, some of the pediatric salivary gland tumors or pediatric sarcomas like fibrosarcomas, they are pathognomonic with NTRK fusions. And again, given that we have a tumor-agnostic approval, now these patients have access to these therapies. And I do not think that we would have had a trial just for pediatric fibrosarcomas with NTRK fusions. So that is one way. Another way is SWOG, right? The SWOG DART [1609] had this combination dual checkpoint, it was called the DART study dual combination chemotherapy with ipi/nivo. Now here the rare cancer subtype itself becomes a biomarker and they showed activity across multiple rare cancer subtypes. They didn't require a biomarker. As long as it was a rare or ultra-rare cancer, these patients were enrolled into the SWOG DART trial and multiple arms have read out. Angiosarcoma, Kaposi sarcoma, even gestational trophoblastic disease. Again, they have shown responses in these ultra-rare, rare cancers. Sometimes they might be seeing one or two cases a whole year. And I think this SWOG effort, this cooperative group effort, really highlighted the need for such studies without biomarkers as well. Dr. Hope Rugo: That is such a fantastic example of how to try and treat patients in a collaborative way. And in the paper, you also emphasize the need for collaborative research efforts, you know, uniting resource expertise across different ways of doing research. So cooperative groups, advocacy organizations that can really help advance rare cancer research, improve access to new therapies, and I think importantly influence policy changes. I think this already happened with the agnostic approvals. Could you tell us more about that? How can we move forward with this most effectively? Dr. Vivek Subbiah: Personally, I believe that collaboration is absolutely critical and essential for rare cancer research. No single institution, no single individual, or no single state or entity can tackle these challenges alone. The patient populations are small and dispersed. So pooling resources is the only way to run these meaningful trials. Again, it is not like singing, it is like putting a huge, huge, I would say, an opera piece together. It is not a solo, vocal therapy, but rather putting a huge opera piece like Turandot. You know, you mentioned cooperative groups. Cooperative groups, as I mentioned earlier, the SWOG DART program, the ASCO [TAPUR study]. ASCO is doing a phenomenal work of the TAPUR study. Again, this ASCO TAPUR program has enrolled so many patients with rare cancers who otherwise would not have treatment options. NCI-MATCH, the global effort, right? NCI-MATCH and the ComboMATCH are great examples. They bring together hundreds of sites, thousands of clinicians to run large-scale trials that would be impossible for any individual center or institution. These trials have already changed practice. For instance, the DART demonstrated the power of immunotherapy in rare cancers and influenced NCCN guidelines. One of the arms of the NCI-MATCH study from the BRAF V600E arm contributed towards the BRAF V600E tissue-agnostic approval. So, the BRAF V600E tissue-agnostic approval was by a pooled analysis of several studies. The ROAR study, the Rare Oncology Agnostic Research study, the NCI-MATCH dataset of tumor-agnostic cohort, and another pediatric trial, and also evidence from literature and evidence of case reports. And all this pooled analysis contributed to the tissue-agnostic approval of BRAF V600E across multiple rare cancers. There are several patient advocacy organizations which are the real unsung heroes here. Groups like, for instance, we mentioned in the paper, Target Cancer Foundation, don't just raise awareness for rare cancer research, they actively connect patients to trials providing financial, emotional support, and even run their own studies like the TRACK trial. They also influence policy to make access easier. On a global scale, initiatives like DRUP in the Netherlands, the ROME study in Italy, the PCM4EU in Europe are expanding precision medicine across these borders. These collaborations accelerate research, improve trial enrollment, and ensure patients everywhere can have access to these cutting-edge therapies. Again, it is truly a team effort, right? It is a multi-stakeholder approach. Researchers, clinicians, investigators, industry, regulators, academia, patients, patient advocates, and their caregivers all working together. And it takes a village. Dr. Hope Rugo: Absolutely. I mean, what a nice response to that. And I think really exciting and it is great to see your passion about this as well. But it helps all of us, I think, getting discouraged in treating these cancers to understand what is happening moving forward. And I think it is also a fabulous opportunity for our junior colleagues as they rise up in academics to be involved in these international collaborative efforts which are further expanding. One of the things that comes up for clinical trials for patients, and I think it is highlighted with rare cancers because, as you mentioned, people are all over the place, you know, they are so rare. They are all far away. Our patients are always saying to us, "Should I go here for a phase 1 trial?" Can you talk a little bit about how we can overcome these financial and geographic burdens for the patients? You talked about having trials locally, but it is a big financial and just social burden for patients. Dr. Vivek Subbiah: Great point. Financial cost is a major barrier in rare cancer clinical trials. It is a major barrier not just in rare cancer clinical trials, but in clinical trials in general. The economics of rare cancer research are one of the toughest challenges we face. Developing a new drug is already expensive, often billions of dollars. On an average, it takes 2 billion dollars or 2.8 billion dollars according to some data from drug discovery to approval. For rare cancers, the market is tiny, which means the pharmaceutical companies have really little financial incentive to invest. That is why initiatives like the Orphan Drug Act were created to provide tax credits, grants, and market exclusivity to encourage development for rare diseases. Clinical trials themselves are expensive because the small patient populations mean longer recruitment times and higher per-patient costs. Geographic dispersion, as you mentioned, for the patients adds travel, coordination. That is why we need to think out of the box about decentralized trial infrastructure so that we can mitigate some of these expenses. Complex trial designs like basket or platform trials sometimes require sophisticated data systems and regulatory oversight. That is a challenge. And I think some of the pragmatic studies like ASCO TAPUR have overcome those challenges. Advanced technologies like next-gen sequencing and molecular profiling also add significant upfront cost to this. Funding is also limited because rare cancers receive less attention compared to common cancers. Public funding and cooperative group trials help a lot, but I think they cannot cover everything. Patient advocacy organizations sometimes step in to bridge these gaps, but sustainable financing remains a huge challenge. So, the bottom line is without financial incentives and collaborating funding models, many promising therapies for rare cancers would never make it to patients. That is why we need system-wide policy changes, global partnerships, and innovative, effective, seamless trial designs which are so critical so that they can help reduce the cost and make research feasible so that we can deliver the right drug to the right patient at the right time. Dr. Hope Rugo: There is a lot of excitement about the future integration of AI in screening. Just at the San Antonio Breast Cancer meetings, we have a number of different presentations about AI to find markers, even like HER2, and using AI where you would screen and then match patients to clinical trials. Do you have any guidance for the rare cancer community on how to leverage this technology in order to optimize patient enrollment and, I think, identification of the best treatment matches? Dr. Vivek Subbiah: I think artificial intelligence, AI, is a game-changer in the making. Right now, clinical trial is clunky. Matching patients to trial is often manual, time consuming, laborious. You need a lot of personnel to do that. AI can automate this process by analyzing genomic data, medical records, and trial eligibility criteria to find the best matches quickly, accurately, and effectively. For the community, the key is to invest in data standardization and interoperability because AI needs clean, structured data to work effectively. Dr. Hope Rugo: Thank you so much, Dr. Subbiah, for sharing these fantastic insights with us on the podcast today and for your excellent article. Dr. Vivek Subbiah: Thank you so much. Dr. Hope Rugo: We thank you, our listeners, for joining us today. You will find a link to Dr. Subbiah's Educational Book article in the transcript of this episode. And please join us again next month on By the Book for more insightful views on key issues and innovations that are shaping modern oncology.  Thank you. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:        Dr. Hope Rugo   @hoperugo   Dr. Vivek Subbiah @VivekSubbiah Follow ASCO on social media:        ASCO on X  ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:       Dr. Hope Rugo:    Honoraria: Mylan/Viatris, Chugai Pharma   Consulting/Advisory Role: Napo Pharmaceuticals, Sanofi, Bristol Myer   Research Funding (Inst.): OBI Pharma, Pfizer, Novartis, Lilly, Merck, Daiichi Sankyo, AstraZeneca, Gilead Sciences, Hoffman La-Roche AG/Genentech, In., Stemline Therapeutics, Ambryx   Dr. Vivek Subbiah: Consulting/Advisory Role: Loxo/Lilly, Illumina, AADI, Foundation Medicine, Relay Therapeutics, Pfizer, Roche, Bayer, Incyte, Novartis, Pheon Therapeutics, Abbvie Research Funding (Inst.): Novartis, GlaxoSmithKline, NanoCarrier, Northwest Biotherapeutics, Genentech/Roche, Berg Pharma, Bayer, Incyte, Fujifilm, PharmaMar, D3 Oncology Solutions, Pfizer, Amgen, Abbvie, Mutlivir, Blueprint Medicines, Loxo, Vegenics, Takeda, Alfasigma, Agensys, Idera, Boston Biomedical, Inhibrx, Exelixis, Amgen, Turningpoint Therapeutics, Relay Therapeutics Other Relationship: Medscape, Clinical Care Options

When you think of “refreshing and rare,” who comes to your mind? What character qualities define this person? I’m guessing they are courageous, personable, persevering. Further, I imagine they are kind and gentle, as well as strong and honest. Most of all, the person who comes to your mind probably lives with hope. As you enter this next year, you need hope, too. The next 12 months provide opportunity to manage, enjoy, and problem-solve in your life. Thankfully, God provides refreshing and rare hope for every day. Read More … For more resources and tools that inspire and equip you to live well using God's Word in practical ways each day, visit the Alive and Active Life website.

From the shadowy northern forests where the elusive Canada lynx roams, to the fragile prairies guarding tiny butterflies and rare orchids. Join us as author Adam Regn Arvidson takes us on a captivating journey through Minnesota's most threatened wild critters and plants.  In his book Wild and Rare: Tracking Endangered Species in the Upper Midwest, Adam shares stories of hope, discovery, and the dedicated people fighting to protect our state's incredible biodiversity.    Presented by Kinetico (kineticoMN.com/), Star Bank (star.bank/), FishUSA (fishusa.com/), Ebels Voyageur Houseboats (ebels.com/), & Disabled American Veterans of Minnesota (https://davmn.org/)

Matthew and Anthony are kicking off 2026 with a powerful message about understanding your identity in Christ and how it relates to living a rare and uncommon life. Each of us is uniquely anointed and gifted for this time, and we must embrace our God-given destiny without looking back at past desires or distractions. Like Lot's wife, who looked back at Sodom and Gomorrah, we must resist the temptation to dwell on what's behind us and instead press forward into the calling God has for us. Our lives are not our own; they belong to God, and we are called to live under the mind of Christ, which is characterized by giving and serving others. Reforming your life means changing the ordinary and stepping into the rare and uncommon blessings God has for you.

In our 2025 year-in-review episode, On Rare reflects on a year filled with meaningful conversations and powerful storytelling. Joined by David Rintell, Head of Patient Advocacy at BridgeBio, and Mandy Rohrig, Senior Director of Patient Advocacy at BridgeBio, we revisit moments that moved us, challenged us, and reaffirmed the importance of listening to the voices of rare disease communities. This year also marked an exciting milestone with the launch of On Rare: Innovators, a new series spotlighting leaders, including patients, caregivers, scientists, and advocates, who are taking action to transform the lives of those impacted by rare disease. We are deeply grateful to all of our guests and listeners for being part of the 2025 journey. Subscribe to continue learning with us in 2026.

Rare books return to monastery library in Votice. Why the ice on the Lipno reservoir has turned green. Michal Smetana on Trump, Greenland and the future of European security.  

AP correspondent Haya Panjwani reports on a record breaking comic sale.

Rare is the professional athlete who plays his entire Hall Of Fame career in his hometown. For 19 years, Barry Larkin did just that, playing for the Cincinnati Reds. His career path took him from a leadoff hitter setting the table, to an RBI man in the heart of the order, with stops up and down the lineup. Along the way Barry Larkin was selected to 12 All Star games, won 9 Silver Slugger Awards, three Gold Gloves, a National League MVP, an Olympic Silver Medal and a World Championship. He was a key ingrediant in the evolution of the Shortstop position, particularly in the National League before inter-league play, combining steady hitting, power, speed and stellar defense. This week we will be discussing one of the revolutionary Shortstops in the game's history; the great Barry Larkin. #BarryLarkin #CincinnatiReds #UniversityOfMichigan #GeneBarrett #KurtStillwell #DaveParker #EricDavis #PeteRose #MargeSchott #BoSchembechler #DaveConcepcion #ChrisSabo

En el episodio inaugural de On Rare: Innovadores, una nueva serie derivada de On Rare de BridgeBio, los presentadores David Rintell, director de abogacía de pacientes de BridgeBio, y Mandy Rohrig, directora sénior de abogacía de pacientes de BridgeBio, presentan a los oyentes a las personas que están transformando la comunidad de enfermedades raras a través de la defensa de los derechos, la compasión y la acción. La serie comienza en Gijón, España, con Carmen Alonso, fundadora de la Fundación ALPE, quien ha dedicado su vida a mejorar la atención y construir una comunidad para las personas y familias que viven con acondroplasia. Lo que comenzó como el viaje personal de Carmen, una madre que buscaba información y apoyo, se convirtió en una red internacional que ha transformado la comprensión y el manejo de la acondroplasia y otras displasias esqueléticas. Acompañada por su hijo Yago y su colega Fani, Carmen reflexiona sobre las lecciones de amor e inclusión que han guiado su trabajo y la convicción de que "siempre se puede hacer algo". A través de la historia de Carmen, On Rare: Innovators celebra a los líderes cuyas ideas y determinación impulsan el cambio en la ciencia, la defensa de los derechos y la comunidad. Su trabajo nos recuerda que la innovación no se encuentra solo en los laboratorios o las salas de juntas, sino que florece dondequiera que las personas decidan actuar con propósito y corazón.

Polar bear mother adopts cub in rarely documented case | BBC This Mama Polar Bear Adopted a Young Cub—and You Can Track the Family as They Wander Around the Hudson Bay | Smithsonian Magazine Sponsored by Factor -use code coolstuff50off to get 50% off your first box plus free breakfast for 1 year. Contact the show - coolstuffdailypodcast@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

The U.S. Supreme Court recently dealt a major loss to President Donald Trump when it ordered him to return control of the Illinois National Guard to the state's governor. The ruling prompted Trump to relinquish control of California's and Oregon's National Guard troops as well.  The decision capped a complicated legal fight that began in June, when Trump sent troops into Los Angeles to respond to immigration raid protests. Marisa unpacks the court's decision with Melissa Murray, a New York University law professor and co-host of the Strict Scrutiny podcast.  Check out Political Breakdown's weekly newsletter, delivered straight to your inbox. Learn more about your ad choices. Visit megaphone.fm/adchoices

Sara Mariotto, MD, PhD - Beyond Myasthenia Gravis: What Are We Learning About FcRn Inhibitors in Other Rare Neuroimmunological Disorders?

When did we truly become Americans — and what did the Founders actually believe about defending our nation? In this powerful episode, Tara dismantles the myth that America was ever meant to be isolationist. From the ratification of the Bill of Rights in 1791, to the Monroe Doctrine just 30 years later, Tara walks through the history the political class hopes you've forgotten — and why it matters right now. This episode connects early American strategy to modern threats: China's control of rare earth minerals, infiltration through student visas, agricultural warfare, and the global pressure campaign unfolding across our hemisphere. This isn't Iraq. This isn't Afghanistan. This is something very different — and very real. History didn't change.

hi hello hey, happy 2026! And more importantly… welcome to season SEVEN of Rare with Flair!

Did Rick Owens really design leather jackets for Ghost of Mars? Is Timothee Chalamet running the exact same PR playbook as Jack Harlow? What the hell is Goouch, and can a goose be a Muppet?Sol and Michael are back! They sit down to break down Rick Owens' early Hollywood costume design work (Ghost of Mars, Tank Girl, Otto; or Up with Dead People), the sock-heel technique that created the iconic pagoda shoulders, and Bailey Goldberg's knitwear producers. The pair then dives into the Timothee Chalamet Marty Supreme PR playbook—from Druski collabs and Chrome Hearts red carpet fits to basketball clout and cultural co-opting—and asks why Hollywood can't let a good actor just act. Finally, a full-blown rant about Front General Store's refusal to stock size Large, a $800 "Viet Cong Hunting Club" military liner, and the ethics of selling Vietnam-era militaria in 2025.They also cover: Lower East Side store tours (Self Edge, Desert Vintage, Commune, Copy, Brute Archives), why Orchard Street is still the fashion capital of New York, Japanese 90s rave culture photography books, the Fear of God represent era fashion time capsule, fake Chrome Hearts dunks, fake Geos flooding the market, Supreme box logo nostalgia, ins and outs list criticism, late 90s and early 2000s horror movie promo tees (House of 1000 Corpses, Flatliners, The Faculty, Planet Terror), why Good Art should make Birkenstock buckles, a heated Muppets debate (what qualifies as a Muppet?), Nine Inch Snails lore, Nicholas Cage movie quotes, Absolute Batman and Doomsday Clock, Happy Gilmore 2 and the nostalgia sequel problem, joggers vs boot cuts, long line tees vs cropped silhouettes, and much more.Big Announcement: The Pair of Kings Podcast turns 6 years old! Join us for the birthday party on Friday, January 16th—free entry, cake, music, and community vibes. Plus: Enter our military surplus giveaway (combat boots + milsurp jacket) through Hero at hero.co/pok.Sol Thompson and Michael Smith explore the world and subcultures of fashion, interviewing creators, personalities, and industry insiders to highlight the new vanguard of the fashion world. Subscribe for weekly uploads of the podcast, and don't forgot to follow us on our social channels for additional content, and join our discord to access what we've dubbed “the happiest place in fashion”.Message us with Business Inquiries at pairofkingspod@gmail.comSubscribe to get early access to podcasts and videos, and participate in exclusive giveaways for $4 a month Links: Instagram TikTok Twitter/X Sol's Substack (One Size Fits All) Sol's Instagram Michael's Instagram Michael's TikTok

Show #781 Originally broadcast 01/05/26 Brenton Wood – Baby You Got It (Double Shot)Ann Sexton – You're Losing Me (Seventy Seven)Bob Kuban and the In Men – Get Out (Musicland USA)Gene Barge – Fine Twine (Checker)Gene Barge – Shake (Checker)Robert John – Raindrops Love and Sunshine (A&M)Cannibal and the Headhunters – Land of 1,000 Dances […]

The second half of the Sorare season is nothing like the first, and that's going to change how everyone plays.In today's Sorare with Laird, I'm joined by Harry Trades to break down why the dynamics of the game shift so dramatically after the midpoint of the season, especially in Rare and Super Rare competitions.We'll discuss:• Why there are fewer cards available on the market as the season goes on• How XP gains and collection bonuses make existing cards significantly more powerful• Why lineup strength starts to matter more than raw spending• How this impacts buying, selling, and roster construction in the second half• What managers should be doing now to prepare for what's comingIf your early season strategy relied on easy upgrades and plentiful supply, the back half of the season can be a wake-up call. This stream is about understanding that shift and adapting before you fall behind.Join Harry's YouTube Community: https://www.youtube.com/channel/UC8HSj8vZDHSGmk5yP46SjtQ/membershipBecome a Laird Social Club Member: https://patreon.com/andrewmlaird

AP's Lisa Dwyer reports on an increase in births for an endangered whale.

Happy New Year listeners! We hope you enjoyed the holidays and are off to a wonderful start of 2026!    The last episode we released featured our Executive Producer Kira Dineen putting on her genetic counseling hat to explore how genetic counselors can help those in the rare disease community. With how much you all enjoyed that “blast from the past” episode, we thought we would bring you one more before our new episodes of 2026 kick off.  So we are continuing on the topic of rare diseases genetics, and revisiting our episode with Amy Patterson, who is a genetic counselor as well. In this conversation she shares with Cathy and Beth about genetic screening and testing available for rare diseases including her speciality of skeletal dysplasia.   Genetic Counselor Amy Patterson shares about genetic screening and testing available for rare disease including her speciality of skeletal dysplasias.    Amy Patterson (she/her) is a licensed pediatric and adult genetic counselor in the Johns Hopkins Department of Genetic Medicine. She primarily works with patients in the Greenberg Center for Skeletal Dysplasias as well as the General Genetics clinic. Especially in the skeletal dysplasia space, Amy works to promote a holistic patient experience, including psychosocial counseling, connection with patient advocacy groups, informed consent, genetic testing and interpretation of results, coordination of care, and discussion of research options. Amy was a LEND Fellow and graduated from the Boston University Genetic Counseling program in 2021. She has focused much of her research and clinical work on the intersection of rare conditions, disability, and patient advocacy.   Amy initially started advocating in the rare disease space due to her best friend's sibling's rare genetic disorder, Congenital Hyperinsulinism. We actually interview their mother on Episode 37 of It Happened To Me. As a high schooler, Amy started educating their peers and community about rare disease on Rare Disease Day every year. After moving to Boston, she started volunteering at a Community Engagement Liaison for the Rare Action Network (RAN), the advocacy branch of NORD, then became the RAN Massachusetts State Ambassador. Through this work, she started putting on Rare Disease Day events at Boston Children's Hospital, and now at Johns Hopkins Hospital as a genetic counselor. Rare Disease Day allows all rare disease stakeholders to come together to share their experiences and continue to learn. Amy is passionate about this global effort to raise awareness and advocate for improved quality of life, diagnosis, and access to care for Rare patients and families.   Want to listen to our other episodes with genetic counselors?    In Episode 4, our Executive Producer, Kira Dineen, who is also a genetic counselor, shares how genetic counselors can help people navigate having a rare disease.    In Episode 7, Genetic Counselor Karen Grinzaid explains prenatal and cancer genetic testing. Kira also joins as a guest host since this is her area of expertise.    Want to speak to a genetic counselor? Find one in your area via FindAGeneticCounselor.org.     Stay tuned for the next new episode of “It Happened To Me”! In the meantime, you can listen to our previous episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “It Happened To Me”.    “It Happened To Me” is created and hosted by Cathy Gildenhorn and Beth Glassman. DNA Today's Kira Dineen is our executive producer and marketing lead. Amanda Andreoli is our associate producer. Ashlyn Enokian is our graphic designer.   See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, ItHappenedToMePod.com. Questions/inquiries can be sent to ItHappenedToMePod@gmail.com.   

The health of Gabe Landeskog immediately became the top priority for the Avs in just their third regulation loss of the year against Florida, but it seems they avoided the worst case with an upper body injury. Additionally, Toews and Blackwood will also some miss some time. The loss to Florida comes on the heels of another great comeback win over the Hurricanes, with the powerplay finally coming through. Team USA also named their Olympic roster, and it sucks, but Brock Nelson made it so it's fine. Send questions to the mailbag here: https://forms.gle/7ytuJfsiTr1x3VDt6 Keep up with everything on the site at HockeyMountainHigh.com Follow the show: @HockeyMTNPod Follow Griffin: @GRYoungs Follow Christian: @Christian_Bolle Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

As we begin 2026, guest speaker Joe Mrugalski explores how we can live into Peter's invitation to be holy as God is holy.

We’re bringing you something special this week in place of our usual daily show. Every day, we are making one of the stories that listeners loved this year free for everyone. Today it is from Smithsonian magazine on how a forgotten bean could save coffee from extinction, written by Marta Zaraska and narrated by Jaime Lamchick for Apple News+.

Thousands of old and rare recordings - some that date back a full century, are now available for the public to enjoy online. That's thanks to a collaboration between UC Santa Barbara and record company Dust-to-Digital. Reporter: Robert Garrova, LAist Mountain lions, foxes, hawks and dozens of other species are dying at an alarming rate from rat poison. Reporter: Erin Stone, LAist Fort Bragg is about three hours north of San Francisco, and during droughts, the former timber town faces severe water shortages. And they're not alone. Nearby communities have had to restrict water in lean years, even while these coastal cities sit next to the biggest body of water in the world. Reporter: Noah Abrams, Northern California Public Media Learn more about your ad choices. Visit megaphone.fm/adchoices