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Where did we come from? One of humanity's most basic questions, the answer is fascinating. Weaving together insights from the fields of genetics, archaeology, linguistics, and paleoanthropology, hosts Spencer Wells and Razib Khan take us on a grand tour of human history. Scientific storytelling at its best.

Insitome: Your guide to the story of you


    • Sep 15, 2020 LATEST EPISODE
    • infrequent NEW EPISODES
    • 54m AVG DURATION
    • 100 EPISODES


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    Latest episodes from The Insight

    Brian Hare and Survival of the Friendliest: Understanding Our Origins and Rediscovering Our Common Humanity

    Play Episode Listen Later Sep 15, 2020 64:10


    Razib discusses the new book Survival of the Friendliest: Understanding Our Origins and Rediscovering Our Common Humanity with one of the authors. https://www.amazon.com/exec/obidos/ASIN/B07ZC6XGGX/geneexpressio-20

    Why Western Europeans are so WEIRD and why that matters!

    Play Episode Listen Later Sep 8, 2020 50:21


    Razib talks to evolutionary anthropologist Joe Henrich about his new book, The WEIRDest People in the World: How the West Became Psychologically Peculiar and Particularly Prosperous, https://www.amazon.com/exec/obidos/ASIN/B07RZFCPMD/geneexpressio-20

    Why much of science is fiction

    Play Episode Listen Later Sep 3, 2020 80:04


    Razib talks to Stuart Ritchie about his new book, Science Fictions: How Fraud, Bias, Negligence, and Hype Undermine the Search for Truth https://www.amazon.com/exec/obidos/ASIN/1250222699/geneexpressio-20

    Siberian paleohistory

    Play Episode Listen Later Aug 6, 2020 79:00


    Razib and Spencer discuss the geography, prehistory, and genetics, of Siberia. Also, the time Spencer experienced a Siberian winter!

    Sundaland: a human evolutionary hearth

    Play Episode Listen Later Jul 31, 2020 93:31


    Razib and Spencer discuss why the geology and biogeography of Southeast Asia may explain why it is so important in the history of human evolution. Show notes: https://blog.insito.me/humanitys-second-cradle-in-southeast-asia-cbb26244f08a

    Peopling the Americas 32,000 years ago

    Play Episode Listen Later Jul 23, 2020 41:55


    Razib discusses revolutionary new work published in Nature that tells us that modern humans were present in the Americas 32,000 years ago with one of the authors, Lorena Becerra-Valdivia. https://www.nature.com/articles/d41586-020-02190-y https://www.nature.com/articles/s41586-020-2509-0 https://www.nature.com/articles/s41586-020-2509-0

    Ghost in the machine

    Play Episode Listen Later Jul 16, 2020 53:42


    Spencer and Razib talk about what we mean when we say "ghost population" in human genetics, and why it's so important to understand our origins. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842210/ https://www.genetics.org/content/192/3/1065.short

    Native American admixture into Polynesia!

    Play Episode Listen Later Jul 9, 2020 44:45


    Razib talks to Alex Ioannidis on the new paper which he is a first author of which argues that there is pre-Columbian Native American ancestry in Eastern Polynesia. Did the Polynesians bring them back from the mainland? Or did they voyage themselves? https://www.nature.com/articles/s41586-020-2487-2

    Will to Power and the Holocene transition

    Play Episode Listen Later Jun 26, 2020 61:48


    Razib and Spencer talk about what a new ancient DNA paper from Neolithic Ireland suggests about radical inequality and power differentials in early agricultural societies, and what that says about the transition from hunting and gathering more generally https://www.nature.com/articles/s41586-020-2378-6 (also, coronavirus update!)

    Two cultures, humanities and science

    Play Episode Listen Later Jun 18, 2020 60:01


    Spencer and Razib discuss what the humanities can offer to science with Kerim Yasar, professor of East Asian literature https://twitter.com/nihonkyo

    Psychiatry and genes

    Play Episode Listen Later Jun 11, 2020 48:48


    Razib talks to Dr. Emily Deans on what's like to work in psychiatry today in a world with personal genomics. https://twitter.com/evolutionarypsy

    American Downfall: Cultural evolution, Peter Turchin, and the return of history

    Play Episode Listen Later Jun 3, 2020 84:33


    Spencer and Razib discuss current events in the context of cultural evolution. The history of decline, the American "Empire", and Peter Turchin's thoughts on social disorder http://peterturchin.com/cliodynamica/the_2020/

    The genetic basis of facial variation

    Play Episode Listen Later May 28, 2020 58:06


    This week Razib talks to Dan Crouch about what we know about the genetics of the variation shape and features. https://www.pnas.org/content/115/4/E676.short

    Ancient DNA and China

    Play Episode Listen Later May 21, 2020 53:30


    Spencer and Razib discuss the latest ancient DNA work that sheds light on East Asian prehistory (and also some coronavirus status update) https://reich.hms.harvard.edu/sites/reich.hms.harvard.edu/files/inline-files/YangSciecne2020.pdf (excuse the "sound effects" early in the podcast!)

    Chris Stringer on paleoanthropology in 2020

    Play Episode Listen Later May 14, 2020 64:30


    Razib catches up with Chris Stinger on the state of paleoanthropology in 2020 and the ramifications of what genetics has taught us about the diversity in Denisovans in the past few years!

    Genetically Modified Organisms

    Play Episode Listen Later May 7, 2020 50:37


    Razib talks to Chad Niederhuth at Michigan State on the promise of GMO agriculture! http://niederhuthlab.com/

    Coronavirus 2020: vaccination and the specter of revolution

    Play Episode Listen Later May 1, 2020 64:32


    Spencer and Razib discuss the state of the pandemic, why Spencer is skeptical of rapid vaccine development, and the political and cultural fallout of COVID-19. https://www.npr.org/sections/health-shots/2020/04/29/847755751/compared-to-china-u-s-stay-at-home-has-been-a-giant-garden-party-journalist-says https://medium.com/@spwells

    Alfred Russel Wallace and the Prehistory of the Indo-Malaysian Archipelago

    Play Episode Listen Later Apr 25, 2020 26:38


    Spencer describes Wallace's encounter with Indonesia and his insight into evolution by natural selection.

    Genetics, genealogy, and secrets unknown

    Play Episode Listen Later Apr 22, 2020 54:15


    Razib talks to Libby Copeland about her new book, The Lost Family: How DNA Testing is Upending Who We Are https://www.abramsbooks.com/product/lost-family_9781419743009/

    Coronavirus 2020: preamble to Weimar?

    Play Episode Listen Later Apr 16, 2020 77:47


    Spencer and Razib discuss the updates to the coronavirus pandemic of 2020 as of mid-April. Spencer delves into the possible social and cultural ramifications, and they both discuss the trajectory internationally and into the future.

    Paleogenetics of East Asia

    Play Episode Listen Later Apr 9, 2020 52:38


    This week Spencer and Razib discuss the latest discoveries about the paleogenetic history of East Asia. Where did the Tibetans, Han, and Japanese come from? https://www.biorxiv.org/content/10.1101/2020.03.25.004606v1 https://www.biorxiv.org/content/10.1101/2020.03.25.008078v1

    Coronavirus pandemic of 2020

    Play Episode Listen Later Mar 31, 2020 95:32


    Razib and Spencer discuss the state-of-the-pandemic at the end of March 2020. https://blog.insito.me/the-insight-show-notes-season-3-episode-13-pandemic-c6640de64d6b

    Natural Selection among indigenous Americans

    Play Episode Listen Later Mar 25, 2020 41:51


    Razib talks to Austin Reynolds about what he's discovered about adaptation in indigenous peoples of the New World. https://www.pnas.org/content/116/19/9312.short

    The Importance of Summer

    Play Episode Listen Later Mar 23, 2020 9:43


    An excerpt from Spencer's book Pandora's Seed about the eruption of Mount Tambora in Indonesia in 1815.

    Genomics of Mendelian Conditions

    Play Episode Listen Later Mar 19, 2020 43:29


    Razib talks to Dr. Jessica Chong of the University of Washington about how genomics has changed how we view and understand rare disorders https://www.sciencedirect.com/science/article/pii/S0002929719302745

    Decreasing genetic diversity with distance from Africa

    Play Episode Listen Later Mar 11, 2020 36:01


    Razib talks to Dr. Sohini Ramachandran of Brown about her classical paper from 2005 which showed decreasing genetic diversity as a function of distance from Africa https://www.pnas.org/content/102/44/15942

    Ancient Egyptian genetics

    Play Episode Listen Later Mar 4, 2020 45:50


    Razib and Spencer talk about the history of ancient Egypt, and the insights genetics can shed on the origins of the ancient Egyptians https://www.nature.com/articles/ncomms15694

    Genetics and (pre)history of Southeast Asia

    Play Episode Listen Later Feb 26, 2020 51:22


    Razib and Spencer talk all things genetic and prehistorical Southeast Asia! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476732/ https://halshs.archives-ouvertes.fr/halshs-02185511/file/Science%20paper%20ORI.pdf https://insitome.libsyn.com/paradise-lost

    Coronavirus and Zoonoses

    Play Episode Listen Later Feb 19, 2020 31:48


    Spencer and Razib discuss the evolutionary and historical context of zoonotic diseases, and their relevance to current events.

    Genetics of Fertility

    Play Episode Listen Later Feb 13, 2020 56:57


    Razib talks to Melinda Mills about the intersection of demographics and genetics. https://www.rsfjournal.org/content/rsfjss/4/4/122.full.pdf

    Genetics of Papuans

    Play Episode Listen Later Feb 4, 2020 61:41


    Razib talks to Anders Bergstrom of the Crick Institute about the genetic history of New Guinea https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802383/

    Paleogenetics of Africa

    Play Episode Listen Later Jan 29, 2020 35:22


    This week Spencer and Razib discuss the ramifications of a new paper which reports on the ancient DNA of West Africans who lived 8,000 and 3,000 years ago. https://reich.hms.harvard.edu/sites/reich.hms.harvard.edu/files/inline-files/Shum_Laka_published_online_0.pdf

    3000 years in the Levant

    Play Episode Listen Later Jan 23, 2020 56:24


    This week Razib discusses the genetics and history of the Levant with Dr. Marc Haber. https://blog.insito.me/3-000-years-in-the-levant-8aba846b18ae

    Predictions for genetics in the 2020s

    Play Episode Listen Later Jan 15, 2020 46:15


    Spencer and Razib offer up 10 predictions for what genetics will bring in the 2020s, from free sequencing to going beyond "Out of Africa." https://blog.insito.me/top-10-human-genetics-evolution-predictions-for-the-2020s-c93f3ef74b4f

    Ten years of human genetics and evolution

    Play Episode Listen Later Dec 20, 2019 113:40


    What was big in human evolution and genetics over the last 10 years? https://blog.insito.me/top-10-human-genetics-evolution-developments-of-the-2010s-1a8c5c213d35?

    Scandinavian Genetics

    Play Episode Listen Later Jun 26, 2019 52:44


    Talking the genetic history of Scandinavians with Torsten Günther. Show notes https://blog.insito.me/the-insight-show-notes-season-2-episode-33-scandinavian-genetics-d4e6e4deeaaf

    Tibetan Denisovans

    Play Episode Listen Later Jun 19, 2019 39:02


    Razib talks about a Denisovan finding from Tibet with Dr. Frido Welker. Show notes: https://pxlme.me/jcQr2gSy

    Obesity and genetic prediction

    Play Episode Listen Later Jun 12, 2019 50:56


    Razib talks to a researcher who developed a method to predict extreme obesity looking at genetic profiles. Show notes: https://pxlme.me/76367O2I

    Evolution of Family

    Play Episode Listen Later Jun 5, 2019 48:09


    Razib discusses the evolutionary and ecological context of human families with Dr. Rebecca Sear. https://blog.insito.me/the-insight-show-notes-season-2-episode-30-evolution-of-family-5f8db79194d9

    Natural Selection and "Deep Learning"

    Play Episode Listen Later May 29, 2019 73:18


    Evolutionary biology and computer science don't seem to have much in common. But this week Razib talks to a geneticist who brings both together in his research. https://blog.insito.me/the-insight-show-notes-season-2-episode-29-deep-learning-and-population-genetics-ffebb7278bc8

    Altitude Adaptation and Denisovans

    Play Episode Listen Later May 22, 2019 52:39


    Razib talks to Emilia Huerta-Sanchez about her finding that altitude adaptation in Tibetans is due to Denisovan admixture. https://pxlme.me/RECg03af

    Neolithic Massacre

    Play Episode Listen Later May 15, 2019 70:36


    This week Razib talks to two researchers who have published a paper that reconstructs the relationships between a group of people who seem to have been killed in a conflict during the Neolithic in Poland. Show notes https://pxlme.me/Iy2T9T_T  

    The Epigenetics Revolution

    Play Episode Listen Later May 8, 2019 49:44


    This week Razib talks to Dr. John Greally on what epigenetics really is, and why it is important. Show notes https://pxlme.me/ZoXCz98p

    The $1000 Genome

    Play Episode Listen Later May 1, 2019 70:03


    Razib talks to Rodrigo Martinez of Veritas Genetics about what the age of "social genomics" will mean to us. https://pxlme.me/uWk0IqrZ

    genetics genomics razib rodrigo martinez
    Deconstructing the Denisovans

    Play Episode Listen Later Apr 24, 2019 75:25


    Spencer and Razib discuss who the Denisovans were, where they lived, and what it means for us as humans. https://pxlme.me/UPzHwYX6

    The ape that understood the universe

    Play Episode Listen Later Apr 16, 2019 61:27


    Razib talks to evolutionary psychologist Steve Stewart-Williams about how the origins of our mind can inform how we interact with the world around us. Show notes: https://pxlme.me/cxm84D_0

    Solving the Missing Heritability

    Play Episode Listen Later Apr 10, 2019 60:40


    Razib talks to Alexander Young on whether the missing heritability is solved, and what it is in the first place https://pxlme.me/LgByOD37

    The genetic history of Ice Age Europe

    Play Episode Listen Later Apr 2, 2019 43:31


    Razib discusses the genetics of Pleistocene Europeans with Cosimo Posth. https://pxlme.me/Rxv09mQ2

    This View of Life: Completing the Darwinian Revolution

    Play Episode Listen Later Mar 27, 2019 54:57


    David Sloan Wilson talks about the application of evolutionary theory to policy and people, and his book, This View of Life: Completing the Darwinian Revolution. https://pxlme.me/PqJs9Qy6

    Historical Linguistics

    Play Episode Listen Later Mar 19, 2019 47:01


    Asya Pereltsvaig joins us to talk about historical linguistics, how language evolution relates to genetic evolution (or not), and what sorts of features are important in creating a phylogenetic tree of languages. https://pxlme.me/S7aXK2Bf

    Irish genetics over the past 10,000 years

    Play Episode Listen Later Mar 13, 2019 64:28


    This week Razib talks to Dr. Lara Cassidy about what genetics can tell us about Ireland's history. https://pxlme.me/mUUwq7u9

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