Podcasts about ancestry

Get ready for another wild week of headlines.  Did you ever submit your DNA to 23 and Me or Ancestry.com?  Well, the CIA might be digging through yours right now to see if it contains extraterrestrial DNA, sorry!  Also, Mackenzie Shirilla is texting her dad about “warm milk”, Charli D'Amelio's parents are stealing her money, a contestant on Love Island looks like Chris Watts, plus so much more!

In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna discuss the unsolved murder of Honoree Fleming from Castleton, Vermont on October 5th, 2023. On October 5, 2023, 77-year-old Honoree Fleming, a beloved retired college dean and accomplished scientist, was fatally shot while walking along a popular rail trail in the quiet town of Castleton, Vermont. Despite witness descriptions of a suspicious man fleeing the scene and ongoing efforts by investigators to track down national leads, this brazen, broad-daylight murder remains a hauntingly unsolved mystery. If you have any information in the murder of Honoree Fleming please contact the Vermont State Police at 1-844-848-8477 and Tips may be submitted anonymously by texting keyword VTIPS to 274637 (CRIMES), or you can submit online anonymously at https://cityprotect.com/forms/state.vt.us/anonymous. This episode was researched by Kathleen Studer. No One Cares About Crazy People: https://noonecaresfilm.com/. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Kensington Publishing: ⁠https://www.kensingtonbooks.com⁠. Sources: Newspapers.com. Ancestry.com. https://www.rutlandherald.com/news/local/castleton-community-approaches-one-year-after-honoree-flemings-death/article_144ca0c4-8285-11ef-ad0f-03b1f9c28149.html. https://www.castletonvermont.org/home/news/vermont-state-police-identify-victim-castleton-homicide. https://vermontbiz.com/news/2024/april/06/vermont-state-police-investigation-continues-killing-honoree-fleming. https://vtdigger.org/2025/08/06/police-contact-arkansas-authorities-in-probe-of-2023-killing-of-honoree-fleming-in-castleton/. https://www.rutlandherald.com/news/local/vermont-state-police-issue-statement-on-honoree-fleming-case/article_95572e13-c17d-422d-affe-1638658635d4.html. https://www.nbcnews.com/news/us-news/man-arrested-deaths-new-hampshire-couple-found-shot-hiking-trail-rcna53586. https://legislature.vermont.gov/Documents/2024/Docs/RESOLUTN/HCR173/HCR173%20As%20Introduced.pdf . Main podcast theme by Kevin Macleod. Check out his work at⁠⁠ ⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠https://www.instagram.com/MissingCSM/⁠⁠. FB:⁠⁠ https://www.facebook.com/MissingCSM⁠⁠. X:⁠⁠ https://twitter.com/MissingCSM⁠⁠. Spotify:⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠. Youtube:⁠⁠ https://www.youtube.com/missingcsm⁠⁠. Apple:⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠. Follow Crawlspace: IG:⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠. TT:⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠. FB:⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠. X:⁠⁠ https://twitter.com/crawlspacepod.⁠⁠ Spotify:⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠. Youtube:⁠⁠ https://www.youtube.com/crawlspace⁠⁠. Apple:⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠. Check out our entire network at⁠⁠ http://crawlspace-media.com/⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Click here to receive today's free gift on the Radio Page:  When is it Right to Die? – In this fold-out pamphlet, Joni Eareckson Tada addresses poignant end-of-life questions, taking into account the inexpressible value of every human soul created in the image of God. This resource provides a biblical framework, Scriptures, and guidance for individuals or families faced with questions around physician-assisted suicide, life-saving measures, and end-of-life challenges.  Use the coupon code: RADIOGIFT for free shipping! *Limit one copy per person* --------Thank you for listening! Your support of Joni and Friends helps make this show possible. Joni and Friends envisions a world where every person with a disability finds hope, dignity, and their place in the body of Christ. Become part of the global movement today at www.joniandfriends.org. Find more encouragement on Instagram, TikTok, Facebook, and YouTube.

What do your DNA test results, extraterrestrials, and a Florida man in a G-string have in common? Absolutely nothing... which makes this week's episode perfect.First, we dive into a wild whistleblower claim alleging the CIA has been combing through consumer DNA databases like 23andMe and Ancestry in a secret hunt for alien-human hybrids. Is this the smoking gun of UFO disclosure? A government genetic dragnet? Or just another conspiracy theory with a suspicious amount of chromosome-based confidence?Then we head to Florida, where a 74-year-old man allegedly turned a quiet neighborhood into an unwanted performance art installation while wearing little more than a G-string and repeatedly asking strangers to jump rope. It's the kind of story that raises important questions, such as "why?" and "please stop."From secret alien bloodlines to barely concealed retirement hobbies, Hysteria 51 explores the strange, the absurd, and the headlines that make humanity seem like it might actually need alien supervision. Buckle up. The truth is out there... but common sense may have already left the building this week on Hysteria 51.Links & Resources

Woooo hooo!  The farm got rain...  Unfortunately, it is a month's worth in a couple days, but hard to complain.Zucchini is growing like mad, did anyone say "zucchini boat for lunch???"Fencing project is getting rolling- fence in section 1 is down, 2 wooden posts set.Acorn is working on applying for Canadian Citizenship by Ancestry...  More of a "because she can" thing- not like the farmers are going to up and skedaddle across the border...  Talk about a project...  Has kept her busy, along with riding the bike.

A sci-fi writer named Jason Reza Jorjani just dropped on a podcast that the CIA has a secret backdoor into 23andMe and Ancestry.com databases so they can scan millions of spit kits for "Nordic" alien bloodlines with weird genetic markers that supposedly scream tall blonde extraterrestrial. Yeah a retired Army psychic spy allegedly spilled the beans about Kit Green running the program to track down these hidden hybrids living among us like it's the plot of a bad X-Files reboot -- no warrants, no proof, just pure conspiracy fuel while the rest of us wonder why the government would need consumer DNA tests when they already hoover up everything else. Watch the podcast episodes on YouTube and all major podcast hosts including Spotify. CLOWNFISH TV is an independent, opinionated news and commentary podcast that covers Entertainment and Tech from a consumer's point of view. We talk about Gaming, Comics, Anime, TV, Movies, Animation and more. Hosted by Kneon and Geeky Sparkles. Get more news, views and reviews on Clownfish TV News - https://more.clownfishtv.com/ On YouTube - https://www.youtube.com/c/ClownfishTV On Spotify - https://open.spotify.com/show/4Tu83D1NcCmh7K1zHIedvg On Apple Podcasts - https://podcasts.apple.com/us/podcast/clownfish-tv-audio-edition/id1726838629 MORE CLOWNFISH TV - Official Merch Store: http://ClownfishMinus.com Facebook - https://facebook.com/ClownfishTV X - https://x.com/ClownfishTVcom Clownfish TV subreddit: https://www.reddit.com/r/ClownfishTVOfficial/ Disclaimer: This series is produced by Clownfish Studios and WebReef Media, and is part of ClownfishTV.com. Opinions expressed by our contributors do not necessarily reflect the views of our guests, affiliates, sponsors, or advertisers. ClownfishTV.com is an unofficial news source and has no connection to any company that we may cover. This channel and website and the content made available through this site are for educational, entertainment and informational purposes only. These so-called “fair uses” are permitted even if the use of the work would otherwise be infringing. #News #Podcast #FYP #Shorts #CIA23andMe #AlienHybrids #23andMeData #AncestryDNA #NordicAliens #DNAHunt #UFOConspiracy #AlienBloodlines #CIAWhistleblower Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

ANTICHRIST EXTREMISM - 05.27.2026 - #944 BestPodcastintheMetaverse.com Canary Cry News Talk #944 - 05.27.2026 - Recorded Live to 1s and 0s Deconstructing World Events from a Biblical Worldview Declaring Jesus as Lord amidst the Fifth Generation War! CageRattlerCoffee.com SD/TC email Ike for discount https://CanaryCry.Support   Send address and shirt size updates to canarycrysupplydrop@gmail.com Join the Canary Cry Roundtable   This Episode was Produced By:   Executive Producers T0Ph*** Cage Rattler Coffee*** Sir LX Protocol Baron of the Berrean Protocol*** Rebecca VM***   Producers of TREASURE (CanaryCry.Support) Rebecca T, Marty Not Sir K, MBH Truth, Joel V, Michael C, Joseph G, Bruce W, Dame Tinfoilhat, Sir Casey the Shield Knight   Producers of TIME Timestampers: Jade Bouncerson, Morgan E Clankoniphius Links: JAM   SIR IKE MEGA BOX GIVEAWAY - Rating/Review, screenshot, send to Sir Ike CanaryCrySupplyDrop@gmail.com   ALIENS/NEPHILIM 11:12 Whistleblower claims CIA used DNA data Ancestry and 23andMe in search for aliens (NY Post)   EXECUTIVE PRODUCERS 40:20   BEAST SYSTEM 1:06:15 New Gig Work - Recording yourself doing chores to train Ai (Wired)   AI 1:53:34 US Law Enforcement Warns of 'Anti-Tech Extremism' as AI Hatred Grows (Wired)   BIBLICAL/POLYTICKS Somehow the Antichrist Returned (Vox)   RFK Jr Clip: RFK Jr takes care of a pair of snakes   PRODUCERS 2:14:44 END 2:24:20

See omnystudio.com/listener for privacy information.

CIA #Alien DNA Search and Disclosure MadnessArticle:A whistleblower has claimed that the CIA used genetic data from consumer DNA testing companies like 23andMe and Ancestry.com to identify individuals with possible extraterrestrial (alien) DNA.Claims:Philosopher Jason Reza Jorjani revealed on the "American Alchemy" podcast that former CIA "psychic spy" Lyn Buchanan told him about the program.Ex-CIA analyst Christopher “Kit” Green allegedly created a backdoor to access DNA data to screen for specific genetic variances linked to non-human beings.The focus is reportedly on "Nordic" aliens — tall, blond, blue-eyed beings who supposedly live covertly among humans (e.g., in small towns in the Colorado Rockies) and pass as Scandinavian.These aliens allegedly came to Earth via an "underground railroad" to escape tyranny on their home planet, interbred with humans, and want their hybrid descendants to live in peace and freedom in America.Additional Details:Buchanan claimed he was approached by three such "Nordics" who asked for help evading CIA detection.He warned against using 23andMe/Ancestry because the government monitors the "other/unknown" ethnicity category in results.This story ties into broader UFO/UAP disclosures, though the Pentagon maintains there is no evidence of extraterrestrial life.The article is framed as sensational "Weird But True" news, relying on second-hand whistleblower accounts without confirmed evidence.AttributionWhistleblower claims CIA used DNA data from Ancestry and 23andMe customers in search for aliensNew York Post Article: https://nypost.com/2026/05/26/lifestyle/cia-used-dna-from-23andme-ancestry-to-hunt-aliens-whistleblower-claims/?utm_medium=social&utm_campaign=nypost&utm_source=twitterRoss Coulthart via Interstellar@InterstellarUAP on XLink - https://x.com/InterstellarUAP/status/2058947450837045391?s=20Tim Burchett via UAP James@UAPJames on XLink - https://x.com/UAPJames/status/2058761757158527047?s=20Philippines Volcano via Daily Loud@DailyLoud on XLink - https://x.com/DailyLoud/status/2059202999604375626?s=20Become a supporter of this podcast: https://www.spreaker.com/podcast/the-tempest-universe--4712510/support.Please follow the #podcast on YouTube: https://www.youtube.com/@TheTempestUniversePodcast?sub_confirmation=1

May 26, 2026Have you had your dose of The Daily MoJo today? Download our app HERE"Human Alien Hybrids! | The Daily MoJo Ep:052626"This episode of The Daily Mojo delves into intriguing topics, from theories about CIA searches for extraterrestrial DNA to the complex situation in Iran. We also examine domestic issues including protests at ICE facilities, rising costs of everyday goods, and political commentary on the Democratic Party's current state.  Additionally, the show covers a tragic accident, an art controversy, and unusual news stories.Phil Bell's Morning Update - They're on the ropes!:  HEREDan Andros - host of The QuickStart Podcast and Managing Editor at CBN.com - Is NOT happy with Facebook Marketplace tactics!FaithwireCBN NewsYouTubeOur affiliate partners:EMP Shield - Figuring out the odds of a devastating EMP attack on the United States is impossible, but as with any disaster, the chances are NOT ZERO, and could happen any day. This decade has proven that the weird and unexpected is right around the corner. Be prepared - protect your home, vehicle, even your generator - with EMP Shield. You'll save money and protect what's important at the same time!ProtectMyMoJo.com Be prepared! Not scared. Need some Ivermection? Some Hydroxychloroquine? Don't have a doctor who fancies your crazy ideas? We have good news - Dr. Stella Immanuel has teamed up with The Daily MoJo to keep you healthy and happy all year long! Not only can she provide you with those necessary prophylactics, but StellasMoJo.com has plenty of other things to keep you and your body in tip-top shape. Use Promo Code: DailyMoJo to save $$Take care of your body - it's the only one you'll get and it's your temple! We've partnered with Sugar Creek Goods to help you care for yourself in an all-natural way. And in this case, "all natural" doesn't mean it doesn't work! Save 15% on your order with promo code "DailyMojo" at SmellMyMoJo.comCBD is almost everywhere you look these days, so the answer isn't so much where can you get it, it's more about - where can you get the CBD products that actually work!? Certainly, NOT at the gas station! Patriots Relief says it all in the name, and you can save an incredible 40% with the promo code "DailyMojo" at GetMoJoCBD.com!Romika Designs is an awesome American small business that specializes in creating laser-engraved gifts and awards for you, your family, and your employees. Want something special for someone special? Find exactly what you want at MoJoLaserPros.com  There have been a lot of imitators, but there's only OG – American Pride Roasters Coffee. It was first and remains the best roaster of fine coffee beans from around the world. You like coffee? You'll love American Pride – from the heart of the heartland – Des Moines, Iowa. AmericanPrideRoasters.com   Find great deals on American-made products at MoJoMyPillow.com. Mike Lindell – a true patriot in our eyes – puts his money where his mouth (and products) is/are. Find tremendous deals at MoJoMyPillow.com – Promo Code: MoJo50  Life gets messy – sometimes really messy. Be ready for the next mess with survival food and tools from My Patriot Supply. A 25 year shelf life and fantastic variety are just the beginning of the long list of reasons to get your emergency rations at PrepareWithMoJo50.comStay ConnectedWATCH The Daily Mojo LIVE 7-9a CT: www.TheDailyMojo.com Rumble: HEREOr just LISTEN:The Daily MoJo ChannelBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-daily-mojo-with-brad-staggs--3085897/support.WATCH: TheDailyMoJO.comLISTEN: TDM RadioRUMBLE: HEREDownload the APP HERE.StellasMojo.comCODE: dailymojo - Save 5%GetMojoCBD.comCODE: dailymojo - Save 40%!

Trump heads to Camp David, dog shoots neighbor, Graham Platner gaffe, Wander Franco found guilty, Dems still mourning George Floyd, CIA using Ancestry and 23andMe, American Sniper widow fires back, HCIS, Flounder’s Funnies, and more.See omnystudio.com/listener for privacy information.

Let us know what you think!#genealogy #familysearch #census #bountylandEpisode OverviewHittin' the Bricks with Kathleen is the genealogy podcast that features your questions and her answers, helping researchers uncover overlooked records and stronger research strategies. In this episode, host Kathleen Brandt answers listener questions focused on three high-impact genealogy sources that can quickly break through stubborn brick walls: Civilian Conservation Corps (CCC) records, Virginia Revolutionary War bounty land grants, and Ireland's newly free 1926 census.Kathleen explains where to search, what clues researchers often miss, and how to connect these records to broader family stories involving migration, military service, inheritance, and identity.In This Episode, You'll Learn Why CCC records are valuable for Depression-era genealogy research  How Revolutionary War bounty land files extend far beyond the first certificate  What makes the 1926 Irish Census important for Irish family history  How supporting records reveal widows, heirs, migration patterns, and community ties  Why original files often contain clues omitted from abstracts and indexes Topics Covered Civilian Conservation Corps records and Depression-era family research  CCC applications and clues about parents, schooling, work history, and migration  Researching CCC records through newspapers, local societies, state archives, and National Park Service collections  Virginia Revolutionary War bounty land digitization  Common mistakes in bounty land research  Warrants, surveys, plat maps, patents, tax lists, deeds, probate, and wills  Why abstract books are not enough for complete genealogy research  Ireland's free 1926 Census and Irish genealogy research  Linking Irish census records to passenger lists, naturalization records, and church documents Episode Discussion & Key MomentsKathleen walks listeners through three record groups that frequently contain overlooked genealogical evidence. The episode begins with CCC records, explaining how applications and related files reveal personal details about family structure, education, employment, and migration during the Great Depression.The conversation then shifts to Virginia Revolutionary War bounty land grants, where Kathleen explains why researchers should never stop at the initial certificate. Supporting documents—including surveys, deeds, probate files, and tax lists—often identify widows, heirs, neighbors, and land relationships that deepen family reconstruction.Finally, Kathleen explores the release of Ireland's 1926 Census, discussing how researchers can connect census findings with U.S. immigration records, naturalization paperwork, and church records to build more complete Irish family histories.Key questions examined include: What records are researchers most likely to overlook?  Why do original files matter more than abstracts?  How can one record group lead to multiple generations of evidence? Resources & Research Tools MentionedNational Archives of Ireland 1926 Census Civilian Conservation Corps (CCC) applications and records  Newspapers and local historical societies  State archives and National Park Service collections  Virginia Revolutionary War bounty land records  Plat maps, tax lists, deeds, probate, and wills  Ireland's 1926 Census  Passenger lists, naturalization records, and church registers Why This Episode MattersMany genealogy breakthroughs come from looking beyond indexes and pulling the full record set surrounding an ancestor. This episode demonstrates how layered research across military, land, labor, and immigration records creates stronger and more accurate family histories.About the PodcastHittin' the Bricks with Kathleen is the genealogy podcast that features your questions and her answers, helping listeners navigate historical records, research challenges, and overlooked sources to uncover deeper family stories.Support the showBe sure to bookmark linktr.ee/hittinthebricks  for your one stop access to Kathleen Brandt, the host of Hittin' the Bricks with Kathleen. And, visit us on YouTube: @HTBKRB with Kathleen John and Chewey video recorded specials. Hittin' the Bricks is produced through the not-for-profit, 501c3 TracingAncestors.org. 

It has shifted my perspective.

Send us Fan MailHuman genetic variation in dietary fat metabolism and its implications for health & disease.TOPICS DISCUSSED:Linoleic Acid Rise: Linoleic acid now comprises 6-8% or more of energy in Western diets.Metabolic Pathways: Omega-6 linoleic acid converts to arachidonic acid and pro-inflammatory oxylipins; omega-3 ALA converts via shared enzymes to EPA/DHA with anti-inflammatory effects.FADS Genetic Variants: Ancestry-linked haplotypes in the FADS cluster create large “pipe” size differences, altering fatty acid by up to 40% between ancestral and derived versions.Population Differences: African ancestry populations often have high-conversion “big pipe” genotypes; Indigenous American ancestry populations have low-conversion “small pipe” genotypes; European ancestry comes with a mix of both.Omega-3 Deficiency: High linoleic intake suppresses EPA production, especially in small-pipe populations, contributing to hypertriglyceridemia and fatty liver in Mexican cohorts.Clinical Evidence: Reanalysis of VITAL trial showed 83% reduction in myocardial infarction with omega-3 supplementation in African Americans; Mexican data link low EPA to unique diabetes forms.Methodological Issues: Compositional data (from GC-FID measurements) versus absolute concentration measurements can flip relationships between linoleic acid and key biomarkers.ABOUT THE GUEST: Floyd Chilton PhD is Professor and Director of the Center for Precision Nutrition and Wellness at the University of Arizona. His research focuses on functional genomics, fatty acid metabolism, and precision nutrition, particularly how genetic ancestry influences responses to dietary fats.RELATED EPISODE:M&M 291: Omega Polyunsaturated Fats & Inflammation | Philip CalderSupport the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

Paizo dropped a Luminary class playtest when we weren't looking! Sam and Stephen give their first impressions, and Sam even made a Luminary for the occasion! Don't forget, your Level 10 Adamantine Chefs must have an Ancestry from the Galactic Ancestries rulebook, a Starfinder class (maybe even a Luminary), and the Wandering Chef Archetype from Pathfinder 2E. Those Bounty Builds are due by May 25th at 11:59pm PST to our email inbox. Please include an outline of what makes your Chef unique mechanically, as well as what brings them to the Adamantine Chef Stage.Jor-Tak, the Luminary ChroniclerPaizo's Starfinder 2E Luminary PlaytestFollow us on Bluesky: thedarktimespod.bsky.socialWant to ask something/submit a build? Email us at: thedarktimespod@gmail.comLogo designed by: @MothPunkStarfinder 2E at PaizoStarfinder 2E SubredditSupport the show Hosted on Acast. See acast.com/privacy for more information.

Send us Fan MailDiscover how awakening is an ongoing journey, not a destination. Learn key insights on Why Your Spiritual Practice Isn't Helping You and  personal and collective growth from Blaise Kennedy's experience in this enlightening discussion.In the quest for spiritual awakening, many often assume it's a singular, transformative event—a moment where everything changes and you Awaken Fully . However Learn Whats Missing, as Blaise eloquently shares in this discussion, awakening is not a conclusion but a continuous journey filled with growth, challenges, and deeper understanding. In this blog post, we'll explore key insights from Blaise's experience, emphasizing that spirituality is an ever-evolving process that impacts not just the individual but the collective. The Myth of Completion in Spiritual AwakeningAwakening is often portrayed as the ultimate goal in spiritual practices. Blaise challenges this notion by emphasizing that what many perceive as the pinnacle of enlightenment is merely a starting point. The journey does not end with self-realization; instead, this realization opens the door to a deeper exploration of consciousness.- **Why This Matters:** Understanding that awakening is ongoing helps to cultivate patience and resilience in our spiritual journeys. - **Common Mistake:** Assuming that once you reach a certain level of enlightenment, your spiritual work is complete.The Dynamic Nature of SpiritualityBlaise highlights that spirituality is not static; it is the movement of the universe itself. He shares that his journey has been characterized by continuous growth and transformation, emphasizing that our experiences and challenges are integral parts of this process.- **Key Insight:** Spirituality reflects the ever-changing dynamics of the universe, and as such, it requires us to adapt and evolve continuously.- **Example from Blaise's Journey:** Blaise recounts how he initially sought to replicate the paths of his teachers but soon realized that each individual's journey is unique, necessitating a personalized approach to spiritual growth. Understanding Trauma and Its Impact on GrowthA significant aspect of Blaise's journey revolves around understanding the effects of trauma—not just personal but collective. He emphasizes that many behaviors and challenges in life stem from unresolved trauma, impacting both individual and collective consciousness.- **Key Insight:** Our individual healing contributes to the healing of our ancestors and the collective consciousness. As we heal, we help to mend the wounds of those who came before us.- **Example from Blaise's Experience:** He illustrates how his physical ailments were not merely personal but resonated with the collective pain of his ancestors, underscoring the interconnectedness of all experiences.

News You Can Use and Share The Zion Cemetery Project in Tampa has moved a step closer to the realization of the creation of a dedicated memorial site. The City of Tampa has agreed to trade land with one of the two major landowners whose building spans some of the Zion Cemetery site. This is a project win in which The Guys were deeply involved, and they celebrate this victory. MyHeritage has introduced Infographics, a new tool that takes your MyHeritage family tree data and generates an attractive graphic highlighting the individuals and events in their lives. MyHeritage's new AI tool, Scribe AI, is now available for iOS and Android devices. George shares details about My Heritage's new record releases. The BBC reported on a new database that allows you to search Nazi Party Membership Cards from Germany for the names of members. Margaret Lance Cheney was awarded the Fellow of the Ohio Genealogical Society. She has served OGS for many years as president and in other capacities. Congratulations on this well-deserved, long-overdue recognition! RootsMagic has announced that Ancestry has changed its API (Application Program Interface) and that RootsMagic has released a new version of the software, Version 11.2.0.0, and that users should upgrade to the newest version in order to connect with Ancestry changes. Older versions of the program still work, but they will no longer connect with Ancestry. FindMyPast has released Ireland, Directories and Almanacs 1844-1928, and the Ireland National Census of 1928. In March, FamilySearch added more than 30 million records from 28 countries. Drew highlights the millions of new records available at FamilySearch. What We're Up To Drew recently presented in person at the Sacramento Genealogical Society in California. Drew announces that RootsTech 2027 is now accepting speaking proposals. Drew will be presenting at the Genealogy Research Institute of Pittsburgh (GRIP), hosted by the National Genealogical Society (NGS). There are both in-person courses and online courses available. George shares that his research on two intermarried lines can be traced back to 15th-century England. These include his fourteenth great-grandparents. The Guys discuss the need for backups for all of your genealogical society officers. This can prevent the loss of access to essential resources and procedures for the organization. Please let us hear from you at genealogyguys@gmail.com with your questions and comments.

My guest today is the artist Charmaine Watkiss, whose extraordinary creative journey took her through film, shoemaking, and advertising before she became fully wedded to her art practice. It's a path that has given her work a deep sense of craft, storytelling and material sensitivity and I know will inspire so many of you. Her paintings are held in public collections across the UK, and she is currently showing a new commission in the National Portrait Gallery's exhibition Artists First: Contemporary Perspectives on Portraiture. We explore how Charmaine actually accesses her ideas. She describes the physical rituals that help her enter a flow state in the studio, how drawing, sculpture, and painting each unlock different ways of thinking, and why the work itself often reveals its direction through the materials. We also talk about responding to museum collections, including her recent commission From the ones who came before… for Exeter's Royal Albert Memorial Museum and Art Gallery, where she worked with objects from the museum's World Cultures galleries to imagine the women who carried botanical knowledge across the African diaspora. We explore why her own figure often appears in the work, and the quiet but powerful role plants play in her paintings as carriers of memory, healing, and connection. It's a fascinating conversation about intuition, research, ancestry, and the slow unfolding of ideas through making. KEY TAKEAWAYS Ideas often begin as something half-visible - a feeling or fragment sensed before it can be understood. The work starts by accessing that inner terrain. Then the materials speak back, slowly revealing a direction you couldn't have predicted. Working with collections isn't neutral; artists are in dialogue with what's missing as much as with what's there. Teasing out and sharing knowledge that would otherwise be lost or misrepresented. BEST MOMENTS “My wanting to connect to plants is because plants have the answers, and plants give us life as well.” “I'm not really interested in making work about trauma. I'm interested in making work about emancipation and about healing.” “She is not trying to claim a definitive narrative. Instead, she creates space for memory, reflection, and reverence. Her practice reminds us that art can be a form of cultural care and repair.” EPISODE RESOURCES https://charmainewatkiss.com https://www.instagram.com/mswatkiss HOST BIO With over 35 years in the art world, Ceri has worked closely with leading artists and arts professionals, managed public and private galleries and charities, and curated more than 250 exhibitions and events. She has sold artworks to major museums and private collectors and commissioned thousands of works across diverse media, from renowned artists such as John Akomfrah, Pipilotti Rist, Rafael Lozano-Hemmer and Vito Acconci. Now, she wants to share her extensive knowledge with you, so you can excel and achieve your goals. ** Ceri Hand Coaching Membership: Group coaching, live art surgeries, exclusive masterclasses, portfolio reviews, weekly challenges. Access our library of content and resource hub anytime and enjoy special discounts within a vibrant community of peers and professionals. Ready to transform your art career? Join today! https://cerihand.com/membership/ ** Unlock Your Artworld Network Self Study Course Our self-study video course, "Unlock Your Artworld Network," offers a straightforward 5-step framework to help you build valuable relationships effortlessly. Gain the tools and confidence you need to create new opportunities and thrive in the art world today. https://cerihand.com/courses/unlock_your_artworld_network/ ** Book a Discovery Call To schedule a personalised 1-2-1 coaching session with Ceri or explore our group coaching options, simply email us at hello@cerihand.com ** Discover Your Extraordinary Creativity Visit www.cerihand.com to learn how we can help you become an extraordinary creative. This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/

Sarah Caterson grew up in a small Pennsylvania town as the oldest of two, until a handwritten letter from her mother in November of 2019 changed everything. The letter revealed a fifty-year-old secret: a baby born in 1969 and forcibly given up for adoption, hidden away in a home for unwed mothers in Scranton. In this episode, Sarah shares the moment she opened that letter, the Ancestry.com match that led her to her half-sister Pam, and the surreal experience of meeting a sibling she never knew existed. Reality Life with Kate Casey What to Watch List: https://katecasey.substack.com Back Story on Podcast: https://katecasey.substack.com/p/i-was-the-narrator-of-my-own-family Patreon: http://www.patreon.com/katecasey Twitter: https://twitter.com/katecasey Instagram: http://www.instagram.com/katecaseyca Tik Tok: https://www.tiktok.com/@itskatecasey?lang=en Facebook Group: https://www.facebook.com/groups/113157919338245 Amazon List: https://www.amazon.com/shop/katecasey Like it to Know It: https://www.shopltk.com/explore/katecaseySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A wounded soldier refuses to dismount. His boot overflowing with blood, his hat riddled with three bullet holes, he rallies his troops up a South Carolina hill in Pennsylvania Dutch. History turns on a single moment. Anne Mitchell, a South Carolina native whose roots run deep in the Palmetto state, joins me to share the story of her sixth great-grandfather, Frederick Hambright, a German immigrant who helped win one of the most decisive (and least talked about) battles of the Revolutionary War. As we count down to America's 250th birthday, Anne shares how a family tree hint on Ancestry led her to the Battle of King's Mountain. There, Hambright's courage helped force Cornwallis to change his entire strategy. This is a story about what it means to stand up when history calls your name and why the most powerful family stories are often the ones nobody told you growing up.〰️

Send us Fan MailThis week on The Art In Fiction Podcast, I'm doing something a little different: a solo episode about my new novel, The Choir, listed in the Music category on Art In Fiction. View the video on YouTube: https://youtu.be/SHb4USfSeE0The family mystery at the heart of the novel: a great-great-grandmother who left her husband with six children in Victorian England and went on to have seven more children with another man, all documented on Ancestry.com.How a chance discovery about Victorian choral competitions and their cash prizes gave Eliza, the novel's protagonist, her escape route and the plot its engine.The role of Carol's mother, a lifelong learner who helped with research before she passed, and her grandmother Granny, who died at 98 and whose reluctance to "get above herself" shaped the novel's themes of class.Research trips to Quarry Bank Mill in Cheshire, where Carol heard the deafening looms firsthand, and to the Birmingham Back-to-Backs, the National Trust's preserved court of working-class Victorian housing.How choir membership was transformative for working-class women in the 1890s; in a world where women had no political voice and no authority at home, a choir gave them a voice that was literally heard.Ruth Henton, Eliza's childhood friend who escaped to the London stage and ends up performing Yum-Yum in Gilbert and Sullivan's The Mikado, and how her glamorous but precarious world eventually collides with Eliza's.The real historical figure Mary Wakefield, who launched the competitive music festival movement in England and makes a cameo in the novel.Why The Choir is Carol's most personal novel: her great-great-grandmother and great-grandmother both have roles, and the novel is her way of giving back the stories of working-class women whose lives rarely make it into the historical record.Reading from The Choir:Read more about Carol M. Cram and The Choir at www.carolcram.comAre you enjoying The Art In Fiction Podcast? Consider giving us a small donation so we can continue bringing you interviews with your favorite arts-inspired novelists.  Click this link to donate: https://ko-fi.com/artinfiction.Also, check out Art In Fiction at https://www.artinfiction.com and explore 2500+ novels inspired by the arts in 11 categories: Architecture, Dance, Decorative Arts, Film, Literature, Music, Textile Arts, Theater, Visual Arts, & Other.Want to learn more about Carol Cram, the host of The Art In Fiction Podcast? She's the author of several award-winning novels, including The Towers of Tuscany, A Woman of Note, The Muse of Fire, and The Choir. Find out more on her website....

Harmful Content Warning: This episode contains raw language including racial slurs, as well as discussions of domestic violence and systemic trauma.Alethia joins me to talk about a childhood defined by internal racism and the messy reality of growing up in a toxic home. We dive into the moment her world shifted when a DNA test completely dismantled her family's origin story, replacing it with a hidden history she never saw coming. It's an honest, sometimes uncomfortable look at the shame that follows a DNA surprise and the heavy emotional cost of carrying secrets you didn't even know existed.Resources Mentioned:Right to KnowDNAngels and Search AngelsOne Drop: My Father's Hidden Life - A Story of Race and Family Secrets by Bliss BroyardFinding Me: A Memoir by Viola DavisGreenlights by Matthew McConaugheyThe Color of Water by James McBrideI Take My Coffee Black by Tyler MerrittReflections: A Window Into My Soul by Alethia SternNPE Stories PatreonNPE Stories facebook pagehttps://www.facebook.com/NPEstories

At 45, MJ Rod discovered that the man she'd believed was her birth father biologically couldn't have been. What followed was a years-long investigation: cold calls, DNA tests, dead ends, and a mother who went silent rather than tell the truth. MJ eventually cracked the case. But the real story isn't about who her father turned out to be. It's about what MJ discovered about herself in the process of finding him, and why it took until 45 for any of it to be possible.Guest Bio Melissa Jean Rod helps women heal from the pain of absent fathers and discover God as the loving Father who never leaves. A proud Texan raised in the little town of Cut and Shoot (yes, it's real), Melissa writes with warmth, wit, and a deep sense of purpose. Married, a mom of six (a mix of step, birth and adopted), and Honey to five wild and wonderful grandsons, she's also a sunset-chasing, chocolate-sneaking, Jesus-loving storyteller. Her debut self-help/memoir, The Daddy Files: A Story of Secrets, Forgiveness, and the Search for Identity is all about healing through honesty, faith, and a little laughter.Turning 40 and Rewriting Your Origin StoryMJ Rod spent most of her life filling in a blank she didn't realize was there. Raised in a warm, loud, loving extended family in Texas, she grew up without her birth father, and built her whole sense of self around pleasing the people who were there. Then, at 45, while tracing her family tree, a blood type on an old military document stopped her cold. The man she had been told and believed was her biological father couldn't have been. What followed was a years-long investigation into her own origins, one that would crack open not just the mystery of where she came from, but everything she thought she knew about who she was.Episode HighlightsMJ discovered at 45 that her birth father wasn't who she'd always believed, not from a confession or a DNA test, but from a blood type she had looked at dozens of times without registering what it meant.With no background in investigation but a lifelong dream of working in law enforcement, MJ built her own case from scratch, tracking down military Facebook groups, cold-calling strangers, and eventually hiring a professional genealogist through Ancestry.com to get her across the finish line.The search led her to her birth father's sister, who welcomed MJ without hesitation and even insisted on doing a DNA test, not because she doubted her, but so MJ would never have to doubt herself again.Finding her biological family didn't just answer a question. It answered a feeling. MJ discovered she shared her father's speech patterns, his curiosity about other cultures, his habit of pausing before he spoke, connection she had been searching for her whole life, arriving through a sister rather than a father.The discovery briefly cracked open every old insecurity MJ had worked to outgrow. But unlike her younger self, she moved through it, and came out the other side with a clarity about her own worth she hadn't had before.MJ also had to reckon with her mother's silence. For a year during MJ's search, her mom stopped returning her calls entirely. What MJ eventually understood was that her mother wasn't angry, she was protecting herself, at MJ's expense.By the time her forties finished with her, MJ had written a book, started a nonprofit, raised money for kids in foster care, learned to love public speaking, and stopped calling herself "just a mom" - for good.Midlife has a way of surfacing what we spent decades avoiding, and MJ's story is proof that the thing you were most afraid to find out might be what finally sets you free. She came into her forties thinking the question was where she came from. She left knowing the more important answer was who she already was.If this episode resonated with you, please take a moment to rate and follow the show and share it with someone who might need to hear it. Guest ResourcesConnect with MJ on Facebook Connect with MJ on InstagramMelissa's websiteAre you stuck in people-pleasing mode?Download Stephanie's People Pleasing Playbook to understand where it comes from, how it's showing up, and what it's costing you. www.thebigfouroh.com/peoplepleaser ConnectTheBigFourOh.comTBFO on InstagramTBFO on FacebookGet the Email DigestListen, Rate & SubscribeYouTube PodcastsApple Podcasts SpotifyAmazon PodcastsSponsorThe Big Four Oh Podcast is produced and presented by Savoir Faire Marketing/Communications

Deb Liu has spent over two decades at the center of tech's biggest moments including PayPal's IPO, Facebook Marketplace, and four years as CEO of Ancestry. Now she's back as co-founder of Ember AI, building enterprise workflow automation at a moment when everything is moving faster than ever. In this episode, Deb gets honest about the career setbacks that almost pushed her out of tech, the personal losses that forced her to pause, and why she couldn't sit out the AI revolution. You'll walk away with practical thinking on how to say no without guilt, how to build teams that never get stuck, why "creator vs. consumer" is the most important distinction for the next generation, and how AI will reshape the way we all develop judgment and expertise at work.Chapters:0:00 How Deb Liu Went from PayPal and Meta to Founding an AI Startup2:30 How Generative AI Arrived Faster Than Anyone in Tech Predicted3:45 Rapid Fire Q1 - What to Do When Things Get Hard6:10 Rapid Fire Q2 - How to Know When to Say Yes or No to Opportunities7:30 Rapid Fire Q3 - How to Stay Motivated When Results Are Slow to Come 9:05 Rapid Fire Q4 - How Introverts Can Learn to Speak Up and Lead at Work 12:00 Rapid Fire Q5 - How Taking a Risk at PayPal Changed Deb Liu's Entire Career13:45 How to Build a Startup Team Culture That Stays Unblocked and Moves Fast18:50 How AI Is Changing Entry-Level Jobs and What the Workforce Needs to Do About It23:15 How to Help Kids Become Creators in a World Built for Consumers26:35 How Ember AI Helps Companies Automate Without Needing Software Engineers35:55 How AI Can Expand Access to Therapy, Education, and Opportunity at ScaleFind Deb OnlineWebsite: https://debliu.com/ Linkedin: https://www.linkedin.com/in/deborahliu/⁠ Substack: https://debliu.substack.com/ Ember AI: https://ember.new/

Let us know what you think!Episode OverviewHittin' the Bricks with Kathleen is the genealogy podcast that features your questions and her answers, helping researchers move beyond online databases and into the archives, collections, and communities where deeper family stories live. In this episode, host Kathleen Brandt gets honest about what researchers cannot afford to forget on a summer genealogy road trip—from choosing the right repositories to asking better questions than simply “Do you have my ancestor's name?”Using examples from research trips to Detroit and Ann Arbor, Kathleen explains why offline records are often the key to understanding the motivations, conflicts, migrations, and community ties that shaped ancestors' lives.In This Episode, You'll Learn Why online genealogy databases rarely tell the full story  How to identify repositories worth visiting in person  What kinds of offline records reveal context and motivation  How archivists and advance preparation improve research results  Why community history matters as much as individual records Topics Covered The limits of online genealogy databases  Researching letters, manuscripts, minutes, and special collections  Prioritizing repositories by time period, topic, and community relevance  Using AI tools to build realistic genealogy research itineraries  Why calling ahead and consulting archivists saves time  Detroit Public Library's Burton Historical Collection  Labor archives and society minutes as sources of conflict and motivation  Ethnic community research and migration patterns  Common genealogy road trip mistakes  Avoiding unnecessary travel for records already available online Episode Discussion & Key MomentsKathleen explains why many genealogy researchers reach a plateau when they rely only on searchable online databases. While digitized records provide access and convenience, they often miss the documents that explain why families moved, joined organizations, changed occupations, or became part of specific communities.Drawing from research experiences in Detroit and Ann Arbor, Kathleen discusses how repositories containing manuscripts, labor records, organizational minutes, and ethnic community collections can uncover motivations and social context absent from census and vital records. She also highlights the importance of preparation—using AI tools, targeted planning, and archivist guidance to make research trips more productive.The episode emphasizes that successful genealogy travel is not about visiting the largest number of libraries, but about identifying the repositories most connected to a family's time period, occupation, migration path, or community network.Key questions examined include: What records are worth traveling to see in person?  How do community archives change genealogical conclusions?  Why do offline collections often explain migration and identity better than databases? Resources & Research Tools Mentioned Detroit Public Library Burton Historical Collection  Labor archSupport the showBe sure to bookmark linktr.ee/hittinthebricks  for your one stop access to Kathleen Brandt, the host of Hittin' the Bricks with Kathleen. And, visit us on YouTube: @HTBKRB with Kathleen John and Chewey video recorded specials. Hittin' the Bricks is produced through the not-for-profit, 501c3 TracingAncestors.org. 

Catastrophic neurologic injury after a routine anesthetic is the kind of signal that stops you in your tracks, and that's exactly why we're talking about new perioperative recommendations for patients with maternal Venezuelan ancestry. We've seen reports of otherwise healthy adults and children who deteriorated after general anesthesia, with sevoflurane appearing repeatedly in the documented events. That pattern has led the American Society of Anesthesiologists and the Society for Pediatric Anesthesia to issue updated guidance aimed at preventing harm while the science catches up. We walk through what clinicians need to know about the suspected mitochondrial link and why maternal lineage matters for risk assessment. We also discuss why a negative family history does not reliably protect a patient and why laboratories must be explicitly alerted to the mutation of interest because it has been historically labeled a normal variant. Then, we get practical: how to screen for maternal Venezuelan heritage with care and sensitivity, how to explain the question without implying anything about immigration status, and how to approach anesthetic planning when definitive genetic testing is unavailable. We cover current thinking on avoiding volatile anesthetics, when regional anesthesia may help, considerations around propofol infusions, processed EEG monitoring, and postoperative observation for return to neurocognitive baseline. If this is helpful, please subscribe, share the episode with your team, and leave a review so more clinicians can find these patient safety updates.For show notes & transcript, visit our episode page at apsf.org: https://www.apsf.org/podcast/306-venezuelan-ancestry-anesthesia-alert/© 2026, The Anesthesia Patient Safety Foundation

Jessica grew up believing she knew the story of her biological father, a high school boyfriend of her mother's who had struggled with addiction and left the picture before Jessica was born. Raised from infancy by the man who became her stepfather in every meaningful sense, Jessica nonetheless carried lifelong questions about her origins, and as an adult pursued a painful, ultimately disappointing relationship with the man she believed had given her half her DNA. Then, decades later, a routine consumer DNA test upended everything: the man she had spent years trying to know was not her biological father at all, and her real biological father was someone else entirely. In this episode, Jessica shares how that discovery forced her to reconsider her identity, her family's history, and the narratives she had been handed since childhood, and how she navigated the twists, the rejections, and the revelations with a remarkable amount of compassion and grace for everyone involved. Reality Life with Kate Casey What to Watch List: https://katecasey.substack.com Patreon: http://www.patreon.com/katecasey Twitter: https://twitter.com/katecasey Instagram: http://www.instagram.com/katecaseyca Tik Tok: https://www.tiktok.com/@itskatecasey?lang=en Facebook Group: https://www.facebook.com/groups/113157919338245 Amazon List: https://www.amazon.com/shop/katecasey Like it to Know It: https://www.shopltk.com/explore/katecaseySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sam and Stephen are diving back into Galactic Ancestries this week! Looking at the illustrious Izalguun and some new favorites for some Pathfinder/Starfinder core ancestries. Don't forget, your Level 10 Adamantine Chefs must have an Ancestry from the Galactic Ancestries rulebook, a Starfinder class, and the Wandering Chef Archetype from Pathfinder 2E. Those Bounty Builds are due by May 25th at 11:59pm PST to our email inbox. Please include an outline of what makes your Chef unique mechanically, as well as what brings them to the Adamantine Chef Stage.Follow us on Bluesky: thedarktimespod.bsky.socialWant to ask something/submit a build? Email us at: thedarktimespod@gmail.comLogo designed by: @MothPunkStarfinder 2E at PaizoStarfinder 2E SubredditSupport the show Hosted on Acast. See acast.com/privacy for more information.

Montes De Oca translated from Spanish means "mountains of Oca or bird similar to a goose" -from an area in the Basque region of Spain in the north central mountains, and that is where Carlyn's family originally emigrated from. Carlyn is a first generation Mexican American who was raised in California. It wasn't until she took a DNA test in her 50's, just to see what her more specific lineage was, that she found out some shocking news. There was a discrepancy in one of the results that caught Carlyn's eye, but being busy, she let it go. She had noticed that all of her siblings seemed to be very quiet and distant once she started asking questions. Had she spent more time on fully reading the results, she would have seen that there was a woman's name listed as a potential relative. "Ancestry DNA doesn't lie" is what Carlyn was told by this stranger's husband. Carlyn's mother and father made a life changing decision based on love and compassion . They didn't hesitate or dwell on the possible difficult road ahead. They did what they felt was the right thing to do. a sister and two brothers that live nearby plus 2 other siblings in  Mexico  that were a lot older. As teens, Carlyn's older siblings suddenly had an adopted baby sister and were told by their parents, not to tell anyone, including their baby sister that she was adopted for fear of someone trying to take her away.  You will never tell her she's adopted because if you do, there are  people out there that may try and hurt her. " Children born out of wedlock where not looked at fondly and Carlyn's parents didn't want that stigma to follow her. When I asked my guest how she's been handling all this upheaval, she says "it's a paradox. Life works in mysterious ways and it gives you the information that you need at exactly at the right time. The first year was really  hard and this is tough stuff."  Her parents  were both strong people and they raised their children to be tough. "It's hard to have the rug pulled out from under you and to loose your identity in the snap of the fingers." I guess you never know what you'll find in your results  when you do a DNA test. It especially is difficult when you get conflicting results as an adult vs a baby or child. Carlyn mentioned LDA or Late Discovery Adoptees. I've attached the link if you'd like further information.        https://www.latediscoveryadoptees.com/ It's been a journey for Carlyn since she got this startling news of being adopted. In the subsequent years, she's done a lot of soul searching and research. She's interviewed many people and family members, found her biological mother and adopted her dog, Grace. November  2022, Carlyn released her most recent book "Junkyard Girl: a Memoir of Ancestry, Family Secrets and Second Chances."  Mary was known for being  very over protective of her daughter and it in fact it caused a lot of contention between the two ladies. She loved her daughter and felt that because she was adopted, she needed to keep an eye on her for her safety. The only regret that Carlyn really has is that her siblings didn't tell her the truth before her parents passed away. Carlyn's older sister thought she was protecting her adopted sibling, just as Carlyn's mother, Mary, thought being over protective would serve her well. Carlyn's Books: "Dog As My Doctor, Cat As My Nurse" "Paws For The Good Stuff-A dog lover's journal" "Paws For The Good Stuff-A cat lover's journal" Discover More https://animalhumanhealth.com/ http://animalhumanhealth.com/media-press/ https://animalhumanhealth.com/book/ https://animalhumanhealth.com/junkyardgirl/ https://animalhumanhealth.com/blog/ https://animalhumanhealth.com/press-kit/carlyns-bio/ https://www.facebook.com/carlynmontesdeoca/ https://www.facebook.com/CarlynMDO https://www.instagram.com/carlynmontesdeoca/ https://www.youtube.com/watch?v=tq8EpIit7Lw         "Should Have Listened To My Mother" is an ongoing conversation about mothers/female role models and the roles they play in our lives. Jackie's guests are open and honest and answer the question, are you who you are today because of, or in spite of, your mother and so much more. You'll be amazed at what the responses are.Gina Kunadian wrote this 5 Star review on Apple Podcast:SHLTMM TESTIMONIAL GINA KUNADIAN JUNE 18, 2024“A Heartfelt and Insightful Exploration of Maternal Love”Jackie Tantillo's “Should Have Listened To My Mother” Podcast is a treasure and it's clear why it's a 2023 People's Choice Podcast Award Nominee. This show delves into the profound impact mother and maternal role models have on our lives through personal stories and reflections.Each episode offers a chance to learn how different individuals have been shaped by their mothers' actions and words. Jackie skillfully guides these conversations, revealing why guests with similar backgrounds have forged different paths.This podcast is a collection of timeless stories that highlight the powerful role of maternal figures in our society. Whether your mother influenced you positively or you thrived despite challenges, this show resonates deeply.I highly recommend “Should Have Listened To My Mother” Podcast for its insightful, heartfelt and enriching content.Gina Kunadian"Should Have Listened To My Mother" would not be possible without the generosity, sincerity and insight from my guests. In 2018/2019, in getting ready to launch my podcast, so many were willing to give their time and share their personal stories of their relationship with their mother, for better or worse and what they learned from that maternal relationship. Some of my guests include Nationally and Internationally recognized authors, Journalists, Columbia University Professors, Health Practitioners, Scientists, Artists, Attorneys, Baritone Singer, Pulitzer Prize Winning Journalist, Activists, Freighter Sea Captain, Film Production Manager, Professor of Writing Montclair State University, Attorney and family advocate @CUNY Law; NYC First Responder/NYC Firefighter, Child and Adult Special Needs Activist, Property Manager, Chefs, Self Help Advocates, therapists and so many more talented and insightful women and men.Jackie has worked in the broadcasting industry for over four decades. She has interviewed many fascinating people including musicians, celebrities, authors, activists, entrepreneurs, politicians and more.A big thank you goes to Ricky Soto, NYC based Graphic Designer, who created the logo for "Should Have Listened To My Mother".MORE INFORMATION ABOUT SHLTMM PODCAST:Link to website and show notes: https://shltmm.simplecast.com/ and https://www.jackietantillo.com/Or more demos of what's to come at https://soundcloud.com/jackie-tantillo Listen wherever you find podcasts: https://www.facebook.com/ShouldHaveListenedToMyMotherhttps://www.facebook.com/jackietantilloInstagram:https://www.instagram.com/shouldhavelistenedtomymother/https://www.instagram.com/jackietantillo7/LinkedIn:https://www.linkedin.com/in/jackie-tantillo/YOUTUBE: https://www.youtube.com/@ShouldHaveListenedToMyMother

On Your World of Creativity, we travel around the world talking with creative practitioners, healers, founders, and changemakers. And today, we're stamping our creative passport in Brisbane, Australia, to talk with someone who's helping millions reconnect with the wisdom of their bodies. If you've ever felt stuck, depleted, or disconnected from your inner clarity, today's conversation may open a powerful new door.Inna Segal is a pioneer in energy medicine and human consciousness, and the internationally bestselling author of The Secret Language of Your Body, translated into 26 languages with more than a million copies sold worldwide. Her work has been praised by leading physicians including Bernie Siegel, Christiane Northrup, and more for its practical, compassionate, and deeply transformative approach to healing.https://www.innasegal.com/masterclassInna's journey began as a young immigrant from Belarus to Australia, where emotional isolation and trauma manifested as chronic illness. At age 20, following the stillbirth of her baby and a profound personal collapse, she experienced a spontaneous healing breakthrough that revealed the emotional, ancestral, and energetic roots of her suffering.That moment became the foundation of her life's work.For more than 25 years, Inna has helped people worldwide—doctors, creatives, trauma survivors, and leaders—understand the deeper messages of the body and activate their own healing abilities. She has taught internationally, created multiple healing decks and programs, and developed a non-linear approach to healing that integrates emotions, archetypes, energy systems, and ancestral patterns.Today, she supports people globally through courses, masterclasses, and intuitive healing work—helping them reconnect with the wisdom of their bodies and the timing of their souls.1) From Personal Crisis to Life's WorkInna, your journey into healing began through profound personal loss and physical pain—from chronic illness to the stillbirth of your baby. Can you share that pivotal moment when you decided to listen to your body differently, and how that experience became the foundation of everything you do today?2) The Secret Language of the BodyYou teach that illness is rarely just physical—and that symptoms often appear far from where the real issue began. What do you mean by the “secret language of the body,” and how can someone begin to understand what their own body is trying to communicate?3) Healing Beyond Symptoms: Emotions, Ancestry, and ArchetypesYour work explores emotional patterns, inherited trauma, masculine and feminine dynamics, and archetypes. From your experience, what deeper layers are most often overlooked in healing—and why can trying to “fix” symptoms too quickly actually be harmful?Inna, where can listeners find your books, courses, and the Awaken the Healer Within masterclass?4) The Soul of Your BrandInna, I want to shift for a moment to what I call the soul of your brand. Using my brand model—clarity of purpose, lived experience, emotional truth, and practical impact—you didn't just build a business, you embodied your message.How would you describe the soul of your work today?What values guide it?And how do you translate something so intuitive and spiritual into grounded books, programs, and experiences that genuinely help people?5) Where to Begin When You Feel OverwhelmedMany listeners may be dealing with emotional stress, physical symptoms, or simply feeling disconnected. When someone feels overwhelmed by everything they're experiencing, where do you recommend they begin? What's one simple way they can start reconnecting with their body and inner healer today?“If someone listening today feels broken, stuck, or disconnected from their body—what would you want them to remember about their own capacity to heal?”

Fear Foods: Why ARFID Is Much More Than Just ‘Picky Eating' While food is often the centerpiece of social connection, those living with avoidant-restrictive food intake disorder, or ARFID, fear these daily meals. Unlike many other eating disorders, this condition is driven by sensory sensitivities or a lack of interest in eating rather than concerns over body weight or composition. Our experts explore treatment options and the reality of navigating a world focused on food when the very act of consuming it feels like an exhausting chore. Guests:  Dr. Kamryn Eddy, professor of psychology, Harvard Medical School, Co-Director, Eating Disorders Clinical and Research Program Cassidy Arvidson, ARFID advocate   The Secret To Productivity: The Big Three Factors Every Space Needs The physical environments where we live, work, and play have a profound impact on our mental state and productivity. Our emotional well-being in any given setting is determined by a psychological formula known as “The Big Three." Leidy Klotz explains these core needs and how we can intentionally design and seek out spaces that help us thrive. Guest: Leidy Klotz, professor, University of Virginia, author, In A Good Place Facebook: ingoodhealthpodX: @ ingoodhealthpodIG: @ingoodhealthpodYouTube: @ingoodhealthpodSpotify Apple Podcast In Good Health PodcastSubscribed to the newsletterFull ArchiveContact UsBecome an Affiliate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Danica Roache didn't see her life experience reflected much in fiction, so she wrote it herself. The result is a funny and tender book, Five Seasons of Charlie Francis, that follows a young Mi'kmaw woman of mixed ancestry as her 5-year plan goes sideways. The book has three nominations at the Nova Scotia and Atlantic Book Awards, and Danica joins Atlantic Voice this week to talk about Indigenous joy, the threats to Nova Scotia publishing, and her top 3 songs currently on repeat.

The Secret To Productivity: The Big Three Factors Every Space Needs The physical environments where we live, work, and play have a profound impact on our mental state and productivity. Our emotional well-being in any given setting is determined by a psychological formula known as “The Big Three." Our expert explains these core needs and how we can intentionally design and seek out spaces that help us thrive. Guest: Leidy Klotz, professor, University of Virginia, author, In A Good Place Host: Greg Johnson Producer: Kristen Farrah Facebook: ingoodhealthpodX: @ ingoodhealthpodIG: @ingoodhealthpodYouTube: @ingoodhealthpodSpotify Apple Podcast In Good Health PodcastSubscribed to the newsletterFull ArchiveContact UsBecome an Affiliate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Don't miss a touching interview with Rayanne Gonzalez from Signature Theatre's Helen Hayes nominated production of In the Heights. 

Dennis is joined via Zoom by actor-writer Michael McHale to talk about his one-person show Searching For Robert Hennessey, which recounts the decades-long search Michael went on for his biological father after his single mother told him the man's name on his 18th birthday. It's an odyssey that involves making out with a guy he met at the Eagle and discovering they may be related, spending years in--and then escaping from--a Christian cult, being diagnosed with HIV/AID and never giving up the hunt, although he wanted to many times. Michael also talks about what it was like to grow up in the projects in Boston, working with Ben Affleck and Michelle Pfeiffer, turning to standup comedy to help him fight AIDS and how he manages to stay sunny in a world with so many clouds. Other topics include: taking his show to the Edinburgh Fringe this summer, blowing the whistle on his sexual abusive uncle, why people should get on Ancestry.com, his book And Hubby Makes Three: A Tragically Fabulous Love Story, his upcoming holiday film Death Takes and Jolliday and why, when he got down to four T cells, he decided to name them Candy, Brandy, Sandy and Dandy. www.SearchingForRobertHennessey.com www.DeathTakesAJolliday.com www.MichaelMcHaleAuthor.com 

Sweet mama,You don't have to wonder who you are: you belong to God's family.

Kyle Matthews interviews Deb Liu, former Facebook senior executive who built the first mobile ad product, created Facebook Marketplace, and launched Facebook Pay, later serving as CEO of Ancestry and now co-founding Ember AI to bring AI-driven enterprise back office automation. Deb explains how Ember identifies workflow “hotspots” where human time is trapped in routinized tasks—often in procurement/invoicing and customer service— then re-orchestrates systems securely for leverage and insight, arguing “fast eats slow” in AI adoption. They discuss practical AI fluency for non-technologists, using multiple models to reduce hallucinations, and concerns about job impact. Deb shares why she started Women in Product, notes a gender gap in AI adoption, recounts her path from Stanford to PayPal and Facebook, reflects on growing up as an immigrant child in South Carolina, and discusses leadership, intentionality, family, and her breast cancer diagnosis and treatment.00:00 AI Is the New Excel00:46 Meet Deb Liu01:58 What Ember AI Builds03:15 Back Office Quick Wins04:27 AI Leverage in Practice08:05 Jobs Fear and Up skilling10:59 Stop Saying I Don't Do AI13:28 Why Women in Product Started16:20 Closing the AI Adoption Gap18:34 Who Wins the AI Race20:34 From Civil Engineering to PayPal25:04 Growing Up as Outsiders28:51 Rocket Fuel and Belonging35:23 Adversity and Tiger Mom37:01 Asian American News Column37:39 Driven to Leave Town38:23 Teaching Kids Adversity40:53 Family Tech Boundaries44:41 Inside Facebook Marketplace48:44 Finding Your Voice51:26 Perfectionism and Growth56:41 From Meta to Ancestry01:00:54 CEO Doubts and Learning01:03:50 Leading Through Lockdown01:05:33 DNA Breakthroughs at Ancestry01:06:40 Privacy and Genetic Risk01:10:59 Mammogram Wakeup Call01:11:40 Diagnosis And Early Biopsy01:13:02 Risk Factors And Fear01:16:13 Treatment And Recovery01:17:56 Building Ember AI01:21:18 Intentionality At Work01:24:30 Habits And New Commitments01:29:16 Career Stall During Motherhood01:35:14 60 60 Marriage Framework01:39:11 Motherhood Penalty Reality01:42:21 Rapid Fire And Wrap Up

Brian Will — Wall Street Journal bestselling author, serial entrepreneur, and founder/CEO of Living Forever AI — joins host Jeff Mains for a wide-ranging conversation on entrepreneurship, scaling, sales, and what it truly means to leave a legacy. Brian has built and helped build companies worth over half a billion dollars across 10 ventures in five industries. Now, he's setting his sights on disrupting the $3 billion genealogy market with AI-powered digital twins that preserve your voice, stories, and personality for future generations — not as static content, but as something people can actually interact with.The conversation covers the mentor relationship that changed Brian's life and fortune, why most companies fail to scale (hint: it's the founder), how to build and audit a high-performance sales team, the self-funded vs. VC debate, and how to compete in a market dominated by giants like Ancestry.com. Brian also shares a vivid philosophy on focus, data-driven sales management, and why right now is the single greatest moment in history to build a company.Key Takeaways4:14 — The Power of a Role Mentor Brian's career turned when he stopped taking only his own advice and started listening to his partner Steve — a $20M entrepreneur who had earned the right to be believed. That one decision led to an $80M exit.11:14 — The Origin of Living Forever AI Watching chatbots evolve and wrestling with his own legacy question — "Who's ever going to know?" — Brian conceived the idea of an interactive AI video twin trained entirely on your own stories and memories.12:43 — Early Traction: Launched Feb. 1, 539 Users in 2 Months Brian describes rapid early momentum, grants, and acceptance into the Startup Grind Global Competition in Silicon Valley — all with a three-person team.22:14 — Why Companies Fail to Scale: It's the Founder The #1 scaling killer is founder ego preventing delegation. Brian calls out founders running $10M companies while doing $20/hour work, and makes the case that CEOs must stop pretending to have all the answers.23:51 — Build a High-Performance, Data-Driven Sales Team Sales and marketing must be measured at every level: ROAS by channel, cost per lead by channel, and revenue per lead. No data = no scale.25:21 — Every Salesperson is an Individual P&L Most companies don't run a true P&L by salesperson. When you do, you'll typically find 20%+ are actually losing money. Cut them, redistribute leads to top performers, and profit goes up without spending a single additional dollar.29:38 — Closers vs. Salespeople vs. Retail Geese Brian breaks down the three tiers of salespeople — and introduces the memorable "retail geese" analogy: people who can fly but sit and wait for apples to fall. Identify which type you have and act accordingly.32:10 — Self-Funded vs. VC: The Discipline Advantage When every dollar comes out of your own pocket, you think differently. Brian contrasts his lean three-person team (launching in weeks) with a funded competitor who raised $11M, hired 15 people, and still has zero customers five months later.35:21 — First Mover Advantage is a Myth "If the first mover was the entire advantage, we'd all still be on MySpace." Brian explains why being an upgrade on an established market (Ancestry.com) is a smarter bet than trying to conquer one from scratch.37:56 — Niche Down, Focus, Then Expand Brian follows Alex Hormozi's framework: get focused, be really good at one thing, then bring in separate teams to take sequential verticals. Chasing the shiny object is a company killer.39:33 — The Biggest AI Mistake Founders Are Making Not fully utilizing AI. Brian replaced a $50K/year graphics employee with ChatGPT at $20/month. AI allows founders to think and build at machine-learning speed — those who ignore it will be left behind.Tweetable Quotes"I made a decision in a split second to listen to somebody else instead of me — somebody who had more success than me. That decision changed everything: my children's lives, the companies that followed, everything I have financially." — Brian Will"If your company isn't scaling the way you want, nine times out of ten it's because your ego is not allowing you to delegate. You're running a $10 million company doing a $20-an-hour job." — Brian Will"Every single salesperson in your organization is an individual profit and loss statement. And when you run that analysis, you'll typically find 20% or more are actually losing money." — Brian Will"We couldn't have done this three years ago. AI gives mankind the ability to 10x their thinking — to think at machine-learning speed and build businesses like no time in history." — Brian Will"If the first mover was the entire advantage, we'd all still be on MySpace. Sometimes the dinosaurs get so big they can't move quick. They get lost in meetings. They can't innovate." — Brian Will"They've created the market. I just want to jump in there, get a piece of it, make it better, and go from there." — Brian Will (on competing with Ancestry.com)"Salespeople are retail geese — they can fly, but they just sit there waiting for an apple to fall." — Brian Will"In the future, your history will be alive. You won't be looking at a piece of paper or reading a journal — you'll click on someone's avatar and talk to them." — Brian WillSaaS Leadership Lessons6 SaaS Leadership Lessons from Brian Will1. Find a Role Mentor and Actually Listen Brian's entire financial trajectory — multiple exits, consulting career, and his current venture — traces back to a single moment of trusting someone with more experience than himself. The best investment a founder can make isn't in software or marketing. It's in finding a mentor who has done what you want to do and getting out of your own way long enough to follow their lead.2. The Scaling Problem Is You Most founders who can't scale are sitting in the bottleneck themselves — answering voicemails, approving invoices, micromanaging design. The transition from operator to leader requires ruthless delegation of everything that isn't your highest-leverage activity. If you think nobody can do it as well as you, that belief will cap your company at whatever you personally can handle.3. Build Sales Like a Finance Department Sales without data is just activity. Brian's framework treats each marketing channel as a measurable ROAS line item, and each salesperson as an individual P&L. Most founders never run this analysis — and are shocked to discover they're paying for salespeople who are net-negative to the business. Measure every dollar, every lead, every close rate. Then cut the bottom and scale the top.4. Know the Difference Between Closers, Salespeople, and Retail Geese As you scale, the average quality of your sales hires will decline — not because you're hiring wrong, but because volume dilutes quality. Build systems simple enough for your worst hire, train rigorously, run P&L by person, and don't mistake activity for performance. Identify your closers and protect their lead flow.5. Bootstrap Your Constraints into Competitive Advantages Constraint forces prioritization. When the money is yours, every decision carries real weight — and that discipline produces lean, fast, profitable companies. Brian's self-funded three-person team outpaced a $11M funded competitor to market. Don't romanticize VC funding; sometimes the resource-constrained team wins simply because they can't afford to waste.6. Own the Niche First, Then Expand Vertically The temptation to chase every application of your technology will scatter your team and dilute your brand. Dominate one market, build the underlying engine, then bring in a dedicated team for the next vertical. Legacy preservation → corporate training → education → homeschool → licensing. The platform stays the same; the focus shifts sequentially. That's how you build a portfolio without losing a company.Guest ResourcesLiving Forever AI: livingforeverai.comBrian Will's Personal Site (books, training, speaking, background): brianwillmedia.comBrian's Books: The Dropout Multi-Millionaire and other titles available at brianwillmedia.combrian@brianwillmedia.comhttps://www.brianwillmedia.com https://www.facebook.com/TheDropoutMM https://www.linkedin.com/in/brian-will-07823b6/ https://www.instagram.com/thedropoutmm/Episode SponsorThe Futureproof Series - https://www.youtube.com/playlist?list=PLfkXKUPZ5xuOqMPR7_gzGybncTtavyR1NThe Captain's KeysSmall Fish, Big Pond –

This episode focuses on the newly updated second edition of the Research Like a Pro with AI genealogy workbook. Nicole and Diana discuss how the book shifts its attention from early 2025 models to the most powerful models available in mid-February 2026, specifically ChatGPT 5.2, Claude Opus 4.6, and Gemini 3. Diana highlights the most significant change, which is the introduction of "agentic" browsers, including Claude in Chrome, Perplexity Comet, and ChatGPT Atlas. These autonomous agents can now perform tasks like actively clicking through family tree lines to find research gaps, navigating library catalogs to compile relevant collections, and autonomously executing research plans directly from a Google Doc. Nicole details the expanded coverage of Handwritten Text Recognition (HTR), which now includes specialized tools such as Gemini in Google AI Studio, Leo for paleography, and Ancestry.com's Image Transcript beta tool. Diana covers the native AI features built into genealogy platforms like Ancestry's "Ideas" and FamilySearch's AI Research Assistant, as well as productivity tools like Goldie May and Airtable. Nicole notes that Airtable AI is now more accessible to free users and describes how its new Omni sidebar can synthesize evidence across multiple rows, such as pulling together scattered land and tax records to build a case for a parent-child relationship. Diana provides crucial privacy updates, alerting users that Claude now trains on user data by default, and she outlines the specific limits on "Deep Research" features. She also discusses NotebookLM's ability to process YouTube video transcripts and Gemini 3's "spatial grounding" capabilities for reading complex historical documents. Listeners learn that the 2026 Second Edition moves from manual AI prompting to autonomous, integrated research workflows, equipping genealogists with cutting-edge efficiency. This summary was generated by Google Gemini. Links Agentic Browsers and Native Integrations: Inside the New Edition of Research Like a Pro with AI - https://familylocket.com/agentic-browsers-and-native-integrations-inside-the-new-edition-of-research-like-a-pro-with-ai/ Research Like a Pro with AI Workbook – Second Edition (eBook) - https://familylocket.com/product/research-like-a-pro-with-ai-workbook-second-edition-ebook/ Sponsor – Newspapers.com For listeners of this podcast, Newspapers.com is offering new subscribers 20% off a Publisher Extra subscription so you can start exploring today. Just use the code "FamilyLocket" at checkout.  Research Like a Pro Resources Airtable Universe - Nicole's Airtable Templates - https://www.airtable.com/universe/creator/usrsBSDhwHyLNnP4O/nicole-dyer Airtable Research Logs Quick Reference - by Nicole Dyer - https://familylocket.com/product-tag/airtable/ Research Like a Pro: A Genealogist's Guide book by Diana Elder with Nicole Dyer on Amazon.com - https://amzn.to/2x0ku3d 14-Day Research Like a Pro Challenge Workbook - digital - https://familylocket.com/product/14-day-research-like-a-pro-challenge-workbook-digital-only/ and spiral bound - https://familylocket.com/product/14-day-research-like-a-pro-challenge-workbook-spiral-bound/ Research Like a Pro Webinar Series - monthly case study webinars including documentary evidence and many with DNA evidence - https://familylocket.com/product-category/webinars/ Research Like a Pro eCourse - independent study course -  https://familylocket.com/product/research-like-a-pro-e-course/ RLP Study Group - upcoming group and email notification list - https://familylocket.com/services/research-like-a-pro-study-group/ Research Like a Pro Institute Courses - https://familylocket.com/product-category/institute-course/ Research Like a Pro with DNA Resources Research Like a Pro with DNA: A Genealogist's Guide to Finding and Confirming Ancestors with DNA Evidence book by Diana Elder, Nicole Dyer, and Robin Wirthlin - https://amzn.to/3gn0hKx Research Like a Pro with DNA eCourse - independent study course -  https://familylocket.com/product/research-like-a-pro-with-dna-ecourse/ RLP with DNA Study Group - upcoming group and email notification list - https://familylocket.com/services/research-like-a-pro-with-dna-study-group/ Thank you Thanks for listening! We hope that you will share your thoughts about our podcast and help us out by doing the following: Write a review on iTunes or Apple Podcasts. If you leave a review, we will read it on the podcast and answer any questions that you bring up in your review. Thank you! Leave a comment in the comment or question in the comment section below. Share the episode on Twitter, Facebook, or Pinterest. Subscribe on iTunes or your favorite podcast app. Sign up for our newsletter to receive notifications of new episodes - https://familylocket.com/sign-up/ Check out this list of genealogy podcasts from Feedspot: Best Genealogy Podcasts - https://blog.feedspot.com/genealogy_podcasts/

This week we welcome back long time friend and guest of the show, Scott Cvecko to share a story that's been unfolding in his life recently. A couple years ago, Scott's son sent his information to Ancestry.com. That one decision triggered a domino effect of events that would reveal family secrets, create new relationships and ultimately result in an ending that was impossible to predict. Listen in to hear this amazing story! Enjoy!

Show #2651 Show Notes: Year of Celebration and Rededication declaration: https://www.whitehouse.gov/presidential-actions/2026/01/year-of-celebration-and-rededication-2026/ The SPLC indictment rewrites the history of the Trump era: https://www.washingtonexaminer.com/restoring-america/fairness-justice/4539867/the-splc-indictment-rewrites-the-history-of-the-trump-era/ Anglo-Saxon: Its Meaning in American History and Ancestry: https://smartscience.blog/anglo-saxon-meaning-american-history-ancestry TST’s […]

John is joined by Shon Morgan and Jack Baumann, both partners in Quinn Emanuel's Los Angeles office. They discuss the growing legal tension surrounding the aggregation and commercialization of publicly available information. It focuses on when compiling public data into structured, searchable databases creates a protectable property interest, and when such activity exposes companies to legal risk.One recent series of cases involves disputes over whether entities that invest substantial resources to digitize, index, and organize public records may prevent others from accessing and reusing that enhanced data. In these cases, courts often recognize a distinction between underlying public records, which remain freely accessible, and value-added compilations created through private investment, which may be entitled to protection.A team led by Jack recently won one of these cases on behalf of Ancestry.com, a genealogy company that invested heavily in digitizing and organizing historical public records. Ancestry partnered with state records archives to convert paper and microfiche records into digital formats, adding searchable indexes and metadata that transformed otherwise difficult to use materials into accessible databases. Although the underlying records remained public and available to anyone willing to retrieve them manually, the company's financial and technical investments significantly enhanced the utility of these public records.The dispute arose when an individual sought to obtain not the original public records, but the company's digitized and indexed versions, through a public records request for Ancestry's work directed at one state's archive. The request effectively attempted to appropriate the company's value-added work product without incurring the costs required to create it. An administrative body initially ruled that the materials should be disclosed, reasoning that the company had acted as an extension of the government in performing a public function. On appeal, however, a higher tribunal rejected that view, concluding that the digitized and organized database was materially different from the original records and not subject to compulsory disclosure.A second series of cases have been brought by individuals whose personal information appears in these searchable databases such as ZoomInfo, Spokeo, or Whitepages.com. Plaintiffs in these cases often assert privacy or right of publicity claims, arguing that even if the data originated from public sources, companies should not profit from compiling and monetizing that data without their consent. Although many of these claims face challenges similar to claims in data breach cases, especially in demonstrating actual harm or the inherent value of ordinary personal information. Some courts have allowed these cases to proceed past the dismissal stage, creating significant potential exposure for companies due to the prospect of class-wide liability and statutory damages.While raw public data remains freely accessible, significant private investment in organizing and enhancing that data may often generate a protectable interest. However, individuals may argue that while their information may be publicly available, they never agreed that third parties could profit from it. This tension remains unsettled and will likely evolve as courts confront similar disputes in other contexts involving large-scale data aggregation.Podcast Link: Law-disrupted.fmHost: John B. Quinn Producer: Alexis HydeMusic and Editing by: Alexander Rossi

What would you do if a single letter revealed that everything you thought you knew about your family was only half the story? Scott Pratt walked into a historic Brooklyn church as part of Ancestry's powerful documentary Railroad Ties expecting to find some connection to his Scottish colonial roots. Instead he discovered that he's a descendant of enslaved people who escaped to freedom on the Underground Railroad. In this deeply moving conversation, Scott and I trace the extraordinary arc of his family tree: from Sophia, the light-skinned Black woman who fled slavery through Brooklyn, to her grandson Frank, a silent film star who kept a journal about passing for white that now sits in the Harvard Library. Scott's story is about so much more than genealogical discovery. It's about the grief of lost stories, the complexity of inherited identity, and the fierce resilience that echoes across generations when we finally let ourselves claim the whole truth of who we are.〰️

On this week's Brands of the Week episode of On Brand with Donny Deutsch, Donny breaks down the brands winning and losing in today's cultural and political landscape — and what it all means for public perception, reputation, and influence. This week's biggest brand stories include: Israel's deepening PR crisis as a new Gallup poll reveals a 31-point drop in support among older Democrats and growing losses across Republicans, Catholics, and evangelicals — and why the Netanyahu factor is accelerating the damage. Plus, Donald Trump signs an executive order expanding federal research into psychedelics like psilocybin and ibogaine — a surprising brand move that earns him a rare brand-up. Then, a potentially game-changing pancreatic cancer drug doubles survival time in clinical trials, offering hope for one of the deadliest cancers. Also covered: Trump's signature on U.S. currency draws a 59% disapproval rating, TMZ opens a Washington D.C. bureau to treat politicians like celebrities, American Eagle doubles down on Sydney Sweeney despite controversy, the FAA recruits gamers as air traffic controllers, Hardee's makes a Southeast comeback, and the Washington Commanders add a spear to their logo. Donny also weighs in on ancestry travel trends, the return of men's monograms, Baby Jessica's fall from grace 40 years later, and the science behind why rewatching Cheers and Golden Girls is actually good for your brain. Thursday's episode features a full interview with entrepreneur and former presidential candidate Andrew Yang on his plans for 2028. Brands mentioned: Israel, Benjamin Netanyahu, Donald Trump, FDA, pancreatic cancer drug Elzovantinib, TMZ, American Eagle, Sydney Sweeney, Hardee's, Washington Commanders, Pittsburgh tech hub, Jill Biden, Heated Rivalry, Maryland state symbol, FAA, 23andMe, Ancestry travel, Andrew Yang Learn more about your ad choices. Visit megaphone.fm/adchoices

This week, In Class With Carr comes from the 42nd International Conference of The Association for the Study of Classical African Civilizations, whose members have worked for over four decades to use the Per Ankh (House of Life) as a model for African renewal. Drawing on presentations in ASCAC's five domestic U.S. regions over the previous year, we consider ASCAC's work as a formation for the consideration of ancestral ways of knowing; a set of varied place-making practices; a community of cultural meaning-makers; a spiritually grounded governance formation rooted in service and a living repository of movement and memory. In this way, ASCAC's work as a House of Life also renews, repositions, and sustains African knowledge as a necessary weapon to be wielded in the face of a hostile and dying contemporary global social structure.Are you a member of Knarrative? If not, we invite you to join our community today by signing up at: https://www.knarrative.com. As a Knarrative subscriber, you'll gain immediate access to Knubia, our growing community of teachers, learners, thinkers, doers, artists, and creators. Together, we're making a generational commitment to our collective interests, work, and responsibilities. Join us at https://www.knarrative.com and download the Knubia app through your app store or by visiting https://community.knarrative.com.To shop Go to:TheGlobalMajorityMore from us:Follow on X: https://x.com/knarrative_https://x.com/inclasswithcarrFollow on Instagram IG / knarrative IG/ inclasswithcarr Follow Dr. Carr: https://www.drgregcarr.comhttps://x.com/AfricanaCarrFollow Karen Hunter: https://karenhuntershow.comhttps://x.com/karenhunter IG / karenhuntershowSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Growing up with a "normal" Midwestern upbringing, Mark never felt different or disconnected from his family. However, after his father's death, a quest to explore his Portuguese heritage through a DNA test led to the staggering discovery that he was 100% Iberian and had zero Polish blood. Now, he shares his journey of navigating this new reality, confronting a mother whose memories are fading, and connecting with a biological family he never knew existed.Mark can be reached via email markthenpe@gmail.comResources Mentioned:Right to Know Severance Magazine DNA Surprises with Alexis HourseltNPE Stories PatreonNPE Stories facebook pagehttps://www.facebook.com/NPEstories

Sally Martell grew up believing she knew her family story, until a DNA test changed everything. In this episode, Sally shares the shocking discovery that the man who raised her was not her biological father. Instead, her DNA revealed something even more unexpected: her biological father was her father's best friend, someone she had known her entire life. Sally opens up about the emotional impact of this revelation, how it reshaped her understanding of her childhood, and the complex layers of family, loyalty, and identity that followed. Reality Life with Kate Casey What to Watch List: https://katecasey.substack.com Patreon: http://www.patreon.com/katecasey Twitter: https://twitter.com/katecasey Instagram: http://www.instagram.com/katecaseyca Tik Tok: https://www.tiktok.com/@itskatecasey?lang=en Facebook Group: https://www.facebook.com/groups/113157919338245 Amazon List: https://www.amazon.com/shop/katecasey Like it to Know It: https://www.shopltk.com/explore/katecaseySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Imagine your biggest AI-powered marketing decision is challenged by your CEO or legal team. Could you, right now, defend both the outcome as well as how the AI arrived at that conclusion?Agility requires more than just speed; it demands the confidence to act on insights decisively. That confidence is impossible if the tools making the recommendations operate like an unexplainable black box.Today, we're going to talk about the growing trust deficit in enterprise AI. While we're all chasing the speed and convenience automation promises, many leaders are realizing that fast answers are useless—and even dangerous—if you can't verify or defend the logic behind them. We'll explore how to move beyond 'black-box' systems to build an AI strategy grounded in transparency, credibility, and true, defensible decision-making.To help me discuss this topic, I'd like to welcome, Chris Willis, Chief Design Officer & Futurist at Domo. About Chris Willis Chris Willis is Chief Design Officer at Domo, where he brings more than 25 years of design and product leadership to the company's data, analytics, and AI platform. Since joining Domo early in its history, he has played a key role in shaping the platform's design strategy, helping make complex data more accessible and useful for customers across industries. Before Domo, Chris co-founded HOUR Detroit magazine and Footnote.com (now Fold3.com), which was acquired by Ancestry.com, and worked as an award-winning illustrator, journalist, and author. His experience blends design thinking, technology, and emerging trends to drive innovation and build tools that solve real business problems. Chris Willis on LinkedIn: https://www.linkedin.com/in/cwillis Resources Domo: https://www.domo.com/ The Agile Brand podcast is brought to you by TEKsystems. Learn more here: https://aglbrnd.co/r/2868abd8085a9703 Drive your customers to new horizons at the premier retail event of the year for Retail and Brand marketers. Learn more at CRMC 2026, June 1-3. https://aglbrnd.co/r/d15ec37a537c0d74 Enjoyed the show? Tell us more at and give us a rating so others can find the show at: https://aglbrnd.co/r/faaed112fc9887f3 Connect with Greg on LinkedIn: https://www.linkedin.com/in/gregkihlstromDon't miss a thing: get the latest episodes, sign up for our newsletter and more: https://aglbrnd.co/r/35ded3ccfb6716ba Check out The Agile Brand Guide website with articles, insights, and Martechipedia, the wiki for marketing technology: https://www.agilebrandguide.com The Agile Brand is produced by Missing Link—a Latina-owned strategy-driven, creatively fueled production co-op. From ideation to creation, they craft human connections through intelligent, engaging and informative content. https://www.missinglink.company Hosted on Acast. See acast.com/privacy for more information.

Imagine your biggest AI-powered marketing decision is challenged by your CEO or legal team. Could you, right now, defend both the outcome as well as how the AI arrived at that conclusion? Agility requires more than just speed; it demands the confidence to act on insights decisively. That confidence is impossible if the tools making the recommendations operate like an unexplainable black box. Today, we're going to talk about the growing trust deficit in enterprise AI. While we're all chasing the speed and convenience automation promises, many leaders are realizing that fast answers are useless—and even dangerous—if you can't verify or defend the logic behind them. We'll explore how to move beyond 'black-box' systems to build an AI strategy grounded in transparency, credibility, and true, defensible decision-making. To help me discuss this topic, I'd like to welcome, Chris Willis, Chief Design Officer & Futurist at Domo. About Chris Willis Chris Willis is Chief Design Officer at Domo, where he brings more than 25 years of design and product leadership to the company's data, analytics, and AI platform. Since joining Domo early in its history, he has played a key role in shaping the platform's design strategy, helping make complex data more accessible and useful for customers across industries. Before Domo, Chris co-founded HOUR Detroit magazine and Footnote.com (now Fold3.com), which was acquired by Ancestry.com, and worked as an award-winning illustrator, journalist, and author. His experience blends design thinking, technology, and emerging trends to drive innovation and build tools that solve real business problems. Chris Willis on LinkedIn: https://www.linkedin.com/in/cwillis Resources Domo: https://www.domo.com/ The Agile Brand podcast is brought to you by TEKsystems. Learn more here: https://aglbrnd.co/r/2868abd8085a9703 Drive your customers to new horizons at the premier retail event of the year for Retail and Brand marketers. Learn more at CRMC 2026, June 1-3. https://aglbrnd.co/r/d15ec37a537c0d74 Enjoyed the show? Tell us more at and give us a rating so others can find the show at: https://aglbrnd.co/r/faaed112fc9887f3 Connect with Greg on LinkedIn: https://www.linkedin.com/in/gregkihlstromDon't miss a thing: get the latest episodes, sign up for our newsletter and more: https://aglbrnd.co/r/35ded3ccfb6716ba Check out The Agile Brand Guide website with articles, insights, and Martechipedia, the wiki for marketing technology: https://www.agilebrandguide.com The Agile Brand is produced by Missing Link—a Latina-owned strategy-driven, creatively fueled production co-op. From ideation to creation, they craft human connections through intelligent, engaging and informative content. https://www.missinglink.company