Podcasts about diels alder

Bioconjugation of antibodies to drugs via chemical linkers is how antibody drug conjugates (ADCs) are made. We're joined by Matt Giese, Senior Scientist at Vector Laboratories, who talks us through the complex chemistry options and biodesign considerations that have to be considered and balanced when making a successful ADC.How does one build the skillset to work in biodesign of ADCs you might ask? Well, Matt's career path might not provide a clearcut roadmap like you might hope. That's because Matt started his career as an auto mechanic, moved into art, went back to auto mechanics, worked as baggage handler and as a construction worker, all before ever finding chemistry. If you think that's a convoluted path, just wait to hear about his academic and professional work journeys.  You'll revel in following this journey, and in the lessons and diverse skills learned along the way. Join us to hear it yourself, from who might just be the most interesting man in chemistry!Related episodes:Season 5, Ep.7: The life-altering impact of one chemist's sabbaticalSeason 2, Ep.1: Chemistry: a modern American dreamSeason 3, Ep.5: On the COVID pill and other process chemistry tales Bonus content!Access bonus content curated by this episode's guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.View the video of this episode on www.thermofisher.com/chemistry-podcast. A free thank you gift for our listeners! Request your free Bringing Chemistry to Life t-shirt on our episode website.Use Podcast Code: LabRatsRul3 in July or OchemRcks in August. We read every email so please share your questions and feedback with us! Email helloBCTL@thermofisher.com

日常被一种平静的“无状态”所填满，喜欢的音乐也越来越静态。但是偶尔，遇到晴好的天气，和对的人一起，吃到了喜欢的午餐，逛了有趣的书店，还是会忍不住想找点有能量的音乐充充电，鼓舞一下自己。 Here's to a good autumn afternoon. 曲目单： (00:36) Sea Power - Please Stand Up (04:23) The Beths - Expert In A Dying Field (09:23) Diels-Alder - 超级法兹男孩 (13:00) Green Day - Warning (17:09) Buzzcocks - Lipstick (19:44) The Lounge Society - Upheaval (24:21) Fazerdaze - Come Apart (27:23) Orange Juice - I Can't Help Myself (33:13) Hallie - Do It (36:59) Yumi And The Weather - Can You Tell (41:05) The Black Angels - Hunt Me Down (44:55) The Cardigans - My Favourite Game (49:05) Gemma Rogers - My Idea Of Fun (53:06) hue - 夕阳 (59:48) Longpigs - She Said → 选曲/撰稿/配音/制作/包装：方舟 → 主题音乐：Yu Su → 题图作者：Federico Beccari, 来自 Unsplash → 题图版式：六花 → 私信/合作联络： 微博/网易云/小宇宙/汽水儿 @线性方舟 → Key Change 随便听歌的分号《KC Jukebox》 → 《周末变奏》WX听友群敲门群主：aharddaysnight

We talk with Dr. George Huber, Richard Antoine Professor of Chemical Engineering at the University of Wisconsin- Madison and the director of Center for Upcycling Waste Plastics (CUWP) about his research in recycling plastics. His technology offers a solution to filtrate the polymer from different plastics by applying solvents solvents. Though multi-layer plastics are more complicated his technology, solvent-targeted recovery and precipitation (STRAP), is able to use thermodynamics and solvents to disintegrate them into their constituent resins. It's a fascinating process - the key is to capture 99% of the polymer and make sure nothing is release into the atmosphere. With consumption of plastics showing no signs of abating, it is crucial to recycle efficiently to reduce the consumption of new plastics. CUWP consists of six universities, over ten industrial partners, one national laboratory, and one industry association. They also share with  scientists, engineers, policy makers, business leaders, and the general public to help them make informed decisions about the costs and benefits of new technologies for plastic recycling. Learn all this and more from Dr. George Huber. https://cuwp.org/https://www.mindfulbusinessespodcast.com/ Art by Xin Zou, University of Wisconsin-Madison for Hochan Chang, Min Soo Kim, George W Huber, James A Dumesic, Design of closed-loop recycling production of a Diels Alder polymer from a biomass-derived difuran as a functional additive for polyurethanes, Green Chemistry (2021) 23, 9479-9488.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.09.334060v1?rss=1 Authors: He, M., Haruehanroengra, P., Khan, I., Sheng, J., Royzen, M. Abstract: Solid phase synthesis of RNA oligonucleotides which are over 100-nt in length remains to be challenging due to the complexity of purification of the target strands from the failure sequences. This work describes a non-chromatographic strategy that will enable routine solid phase synthesis of long RNA strands. The optimized five-step process is based on bio-orthogonal inverse electron demand Diels-Alder chemistry between trans-cyclooctene (TCO) and tetrazine (Tz) and entails solid phase synthesis of RNA on a photo-labile support. The target oligonucleotide strands are selectively tagged with Tz. After photocleavage from the solid support, the target oligonucleotide strands can be captured and purified from the failure sequences using immobilized TCO. The approach was optimized using a model 20-mer DNA strand and was successfully applied towards synthesis of 76-nt long tRNA and 101-nt long sgRNA. Purity of the isolated oligonucleotides was evaluated using gel electrophoresis and mass spectrometry, while functional fidelity of the sgRNA was confirmed using CRISPR-Cas9 experiments and flow cytometry. Copy rights belong to original authors. Visit the link for more info

Synthetic studies towards the total synthesis of the natural polyketide portentol. Synthetic studies to thiocarbonyl ylide based 1,3-dipoles. An efficient formal synthesis of dimethylglutamine via [3+2] cycloaddition of a thiocarbonyl ylide and subsequent Raney nickel reduction. Synthetic studies towards vinyl-quinone-Diels-Alder reactions. The first X-ray crystal structure of the Dess-Martin Periodinane

Part I: Total Synthesis of Variecolortides A–C The variecolortides are structurally intriguing, fungal natural products that present a unique merger of three major streams of biosynthesis. They can be traced back to other known natural products, namely the viocristins and echinulins, and we wanted to prove if they could somehow come together to form the variecolortides. Thus, these natural products were prepared in short sequences and their critical linkage was subsequently investigated. It was found that an unprecedented hetero-Diels-Alder reaction effected this linkage and furnished the central spirocyclic core of the variecolortides. Ultimately, a highly convergent route to all three variecolortides (A–C) was developed. The natural products were each efficiently synthesized as racemates in seven steps or less (longest linear sequence), largely avoiding protecting group chemistry. Part II: Towards the Total Synthesis of Naphthomycin K and Divergolides C and D Ansamycins are an important class of natural products that often show potent antibacterial and antiviral activities. We have engaged in the total syntheses of several new aminonaphthoquinone ansamycins, including naphthomycin K and divergolides C and D. A unified approach to their naphthoquinone core was targeted and led to the development of a novel, cyano-substituted Danishefsky-type diene. The latter was used in the synthesis of cyano-substituted naphthoquinones, naphthalenes and other highly functionalized small molecules. Since the cyano-substituted naphthoquinones could not be further elaborated into the desired natural products, alternatively substituted bromonaphthalenes were instead synthesized over short sequences. In addition, several strategies towards the synthesis of an ansa chain fragment of divergolides C and D were developed. Part III: Synthesis of Photochromic Open-Channel Blockers Optical control of transmembrane ion channel function with high temporal and spatial precision opens the door for a better understanding of neuronal circuits and pharmacological associated questions. Several red-shifted derivatives of QAQ (quaternary ammonium- azobenzene-quaternary ammonium), a powerful doubly charged photochromic blocker, have been synthesized. They allow for remote control of Kv and Nav channel conductance with light and offer the opportunity to reversibly silence neuronal activity.

Loline is the eponymous member of an alkaloid family, originally isolated in 1892 from tall fescue grasses, but later found in many other plant families. They are produced by endophytic fungi and are as toxic to insects as nicotine, thereby protecting the host plant from herbivores, but many aspects of their chemical ecology are not yet understood. Despite its long history and intriguing biological activity, there has been only one successful asymmetric synthesis of loline to date, which required 20 steps. This may be due to its strained, heterotricyclic molecular skeleton, that incorporates polar functionalities in close proximity, thus rendering the loline alkaloids more challenging targets than they may appear at first sight. This dissertation deals with different approaches for the synthesis of loline alkaloids and reports interesting outcomes. The synthesis, which finally led to success is efficient and asymmetric and requires only 10 steps. The synthesis is scalable, diversifiable, gives access to all loline alkaloids and has served to provide several research groups sufficient material to investigate the interesting chemical ecology of these alkaloids. The naphthomycins are a class of ansamycin antibiotics that contain a macrocycle of polyketide origin with an amide linkage to a naphthalenic moiety. To date, 11 different naphthomycins (naphthomycin A–K) have been isolated and structurally elucidated. In spite of their unique structure and broad spectrum of biological activities, none of the naphthomycins have been synthesized to date. This dissertation includes the syntheses of two building blocks from inexpensive commercially available starting materials in 9 steps each and their coupling in a Horner-Wadsworth-Emmons reaction (HWE) and further transformation to give the C6-C23 fragment of all naphthomycins. In addition, a naphthoquinone precursor has been synthesized starting from a literature known quinone and a novel Danishefsky-type diene. The synthesis of the novel Danishefsky-type diene and its reactivity in Diels-Alder reactions is reported.

Cyclic conjugation that arises when p-orbitals touch one another can be as important for transition states as aromaticity is for stable molecules. It is the controlling factor in “pericyclic” reactions. Regiochemistry, stereochemistry, and kinetics show that two new sigma bonds are being formed simultaneously, if not symmetrically, in the 6-electron Diels-Alder cycloaddition. Although thermal dimerization of thymine residues in DNA is forbidden, photochemistry allows the 4-electron cycloaddition. “Electrocyclic” ring opening or closing chooses a conrotatory Möbius pathway, or a disrotatory Hückel pathway, according to the number of electron pairs involved and whether light is used in the process. Dewar benzene provides an example of a very unstable molecule that can be formed photochemically and then persists because of unfavorable orbital overlap in the transition state for ring opening. Complete course materials are available at the Open Yale Courses website: http://oyc.yale.edu This course was recorded in Spring 2011.

Transition state modelling; reaction coordinates and aromatic electrophilic substitution. Pyridine, concerted vs Wheland intermediates. The Diels Alder reaction in a cavity.

http://webs.anokaramsey.edu/aspaas/2061/video/14.4%20The%20Diels-Alder%20cycloaddition%20reaction-0.m4v Sat, 15 Jan 2011 09:03:02 -0600 Higher Educati

http://webs.anokaramsey.edu/aspaas/2061/video/Problem-solving%20with%20the%20Diels-Alder%20reaction-0%20%282%29.m4v Sat, 15 Jan 2011 09:03:01 -0600 Higher Educa

Conjugation, MOs, allylic carbocations, Diels-Alder reaction, UV spectroscopy

The non-classical norbornyl cation, the transition state model for nitration of pyridine. Case study 6 revisited; the transition state for the Diels Alder reaction both inside and outside a cavity.

Analysis of two case studies in molecular mechanics, the first involving the use of a chiral template to transfer chirality during the reaction between benzylamine and an ester to form an amide, and the second dealing with how a Diels Alder reaction is catalysed by occurring inside a cavitiy, or molecular anvil.

An overview of cycloaddition and elimination reactions, including examples of the Diels Alder reaction.

Fri, 19 Jul 2002 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/121/ https://edoc.ub.uni-muenchen.de/121/1/Brandl_Doris.pdf Brandl, Doris ddc

The hexamethyl substituted bismethylenecyclopentane 1a is 4 to 7 times more reactive towards the acetylenic dienophiles 2 and 3 than the nonmethylated 1,2-bismethylenecyclopentane 1b. This unusual consequence of branching is explained in terms of steric and electronic effects.

Sat, 1 Jan 1983 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3823/ http://epub.ub.uni-muenchen.de/3823/1/036.pdf Bäuml, Englbert; Mayr, Herbert Bäuml, Englbert und Mayr, Herbert (1983): Diels-Alder reactions of 2-alkynoyl chlorides with cyclopentadiene. a reinvestigation. In: Journal of Organic Chemistry, Vol. 48, Nr. 15: pp. 2600-2601. Chemie