Podcasts about Medicinal chemistry

Se gli atomi diventano lettere, le molecole possono diventare parole, o intere frasi. Analogamente a come i Large Language Model sono addestrati a parlare il linguaggio naturale, un software di Intelligenza Artificiale può essere addestrato a parlare il linguaggio della chimica. Su questa linea si è mossa l'Università di Pisa, che in un articolo pubblicato sull'European Journal of Medicinal Chemistry ha descritto un nuovo modo per progettare molecole farmacologiche basate su quello che vengono chiamati “chemical language models”, modelli linguistici ispirati a quelli usati nei chatbot come ChatGPT, ma addestrati a leggere e scrivere il linguaggio molecolare. Ce ne parla Tiziano Tuccinardi, Professore di Chimica Farmaceutica del Dipartimento di Farmacia dell'Università di Pisa.

Dr. Keith Ellis is a Scientist and Associate Professor of Medicinal Chemistry that is using his knowledge & expertise in medicinal chemistry, pharmacology, and natural products to research the biological mechanisms that cause Long Covid and create custom-formulated, over-the-counter solutions for Long Covid that are safe, inexpensive, accessible for everyone.Long Covid Research, Social Media Links, and LinkedIn Profile can be found at www.keithcellisphd.com.Order CircuGuard at circuguard.comIn this episode we discuss:the physiology and mechanisms causing long covid symptomspotential treatments for long covidhypercoagulation: causes + remediesLong covid's connection to Lyme, CFS, fibromyalgia, and autoimmune conditionsConnect with Theresa:EFT Tapping app & membership: www.tappingwitht.comInstagram: @livingrootswellnessBlog: www.livingrootswellness.comcontact Theresa: theresa@livingrootswellness.com

In this episode, Keith Ellis, PhD, joins Evan H. Hirsch, MD, to explore whether a herbal solution could replace triple anticoagulant therapy for Long COVID microclots.   Dr. Keith Ellis is a scientist and Associate Professor of Medicinal Chemistry who has dedicated his expertise to helping people recover from Long Covid. With a strong background in medicinal chemistry, pharmacology, and natural products, he investigates the biological mechanisms behind Long Covid and explores therapeutic pathways for recovery.   Driven by both scientific curiosity and entrepreneurial spirit, Dr. Ellis founded Science-Driven Supplements in 2023 and launched CircuGuard, a custom-formulated herbal supplement designed to support recovery from Long Covid microclots. His mission is to create natural solutions that are safe, affordable, and accessible with no prescription needed.   In parallel, Dr. Ellis continues his academic work, conducting early-stage oncology drug discovery research and teaching organic and medicinal chemistry at the graduate and undergraduate levels. His unique integration of cutting-edge science and real-world application is helping bridge the gap between research and recovery for those affected by Long Covid.   Learn more about Dr. Ellis's work at: https://keithcellisphd.com/   .   We help you resolve your Long Covid and Chronic Fatigue (ME/CFS) by finding and fixing the REAL root causes that 95% of providers miss. Learn about these causes and how we help people like you, Click Here. Do you have fatigue, brain fog, shortness of breath, muscle pain, or other strange symptoms? You might have Long Covid. Take our free quiz to find out if Long Covid is behind the mystery symptoms you're experiencing, Click Here.   For more information about Evan and his program, Click Here.   Prefer to watch on Youtube? Click Here.   Please note that any information in this episode is for educational purposes only and does not constitute medical advice.

Synopsis: How do you build a biotech company that disrupts drug discovery and delivers real impact? In this episode of Biotech 2050, host Rahul Chaturvedi speaks with Raj Devraj, President & CEO of Rectify Pharmaceuticals and Venture Partner at Atlas Venture. Raj shares his journey from big pharma to biotech entrepreneurship, the science behind Rectify's groundbreaking approach to drugging membrane proteins, and how his team is tackling rare hepatobiliary diseases with small-molecule therapies. He also dives deep into biotech innovation, smart capital strategy, M&A trends, and the power of hiring the right talent. Whether you're a biotech founder, investor, or science enthusiast, this episode is packed with insights on building, funding, and scaling a biotech startup in today's competitive landscape. Biography: Rajesh (Raj) Devraj, Ph.D., is President and Chief Executive Officer of Rectify Pharma and a Venture Partner at Atlas Venture. Throughout his career, he has been focused on creating and building groundbreaking biotech companies. Prior to Rectify, Raj co-founded Disarm Therapeutics with Atlas and served as its Chief Scientific Officer prior to its acquisition. Before Disarm, he served as Chief Scientific Officer of Atlas-founded Padlock Therapeutics. Prior to his tenure at Atlas, Raj served in senior executive roles at Euclises & Deciphera Pharmaceuticals and at Jubilant Life Sciences. In addition, Raj spent 14 years in positions of increasing responsibility with Pfizer Global R&D and the legacy Pharmacia and Searle companies. Raj also serves on the boards of directors for several biotech companies. Over a 25-year career in large pharma and biotech, Raj has led discovery, early clinical development, and strategic planning teams that have advanced multiple candidates into clinical trials for refractory cancers, autoimmune diseases, IPF, diabetic nephropathy, COPD, and pain. Raj received his B.S. in Pharmacy from the University of Mumbai, and Ph.D. in Medicinal Chemistry from Duquesne University.

Send us a textDr. Hernan A. Bazan MD, FACS, CEO & Co-Founder of South Rampart Pharma, Inc. ( https://southrampartpharma.com/about-us/hernan-bazan/ ), a clinical stage biopharma company developing safer, non-opioid therapies for acute and chronic pain, where he spearheads the company's scientific, clinical and technology development efforts, as well as it's fundraising. As an academic vascular surgeon, Dr. Bazan is the John Ochsner Endowed Professor of Surgery in Innovation ( https://www.ochsner.org/doctors/hernan-bazan ). His clinical interests include treating carotid artery disease and acute stroke, using minimally invasive approaches to aortic aneurysms and peripheral arterial disease, and managing acute post-operative pain. Over the years, Dr. Bazan has realized the significant clinical and societal need for safer and non-addictive pain relief in ambulatory and post-operative settings. From these critical unmet needs, South Rampart Pharma, Inc. was founded in 2016 to develop safer, non-opioid therapies for acute and chronic pain.Dr. Bazan authored the first manuscript describing the library of analgesic compounds' synthesis, lack of hepatoxicity analgesic characterization, and antipyretic properties, published in September 2020 in the European Journal of Medicinal Chemistry and a current paper under advanced review (open access) in Nature Communications.Dr. Bazan is the PI or Co-I on two NIH/NINDS STTR (small business commercialization) grants to develop a novel non-narcotic and non-toxic analgesic to safely treat acute, chronic, and neuropathic pain. He is the co-inventor of 7 issued or pending patents and has authored over 50 publications. He and his team have completed Phase 1 clinical trials, paving the way for Phase 2 RCTs in acute and neuropathic pain. He was bestowed the 2024 NIH HEAL Director's Trailblazer Award for this work.Dr. Bazan received a B.S. in Molecular Biology (Vanderbilt University). He spent two years in medical school as a Howard Hughes Medical Institute (HHMI) Research Scholar at the NIH. He earned an M.D. (Georgetown University), followed by a General Surgery Residency (Mt. Sinai Hospital, New York) and a Vascular Surgery Fellowship (Yale University).#Pain #Opioids #NSAIDS #Acetaminophen #Analgesia #Nociception #PostOperative #HernanBazan #NicolasBazan #SouthRampartPharma #Ochsner #Fentanyl #Aspirin #Ibuprofen   #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show

Hey Friends,Help me make this year of Nina's Notes great by filling out this quick survey. Share your feedback about Nina's Notes and share some information about you so I can create the content you want to read.It will take just 3 minutes to complete.Thank you! Thank you!On this episode I sit down with Keith C Ellis, PhD, an Associate Professor in the Department of Medicinal Chemistry at Virginia Commonwealth University and a natural products chemist.He is the founder and CEO of Science-Driven Supplements, where he uses his knowledge of physiology, pharmacology, drugs, and natural products to create products to tackle big public health challenges.Keith was frustrated with the treatment options for long COVID, and used his expertise in natural product chemistry to reverse engineer a solution based on the positive results shown from using anticoagulant drugs to treat long COVID.The resulting product is called CircuGuard, which combines three natural ingredients that target the same biological pathways as triple anticoagulant therapy, in a dose which is safe for over-the-counter use.Listen to the episode on

Matters Microbial #67: Chemical Communication in Microbe Symbioses November 27, 2024 Today, Dr. Marcy Balunas, Associate Professor of Microbiology and Immunology, as well as part of the Department of Medicinal Chemistry at the University of Michigan, joins the #QualityQuorum to discuss how her group investigates the chemical signals—the language—between host and microbe symbioses. Host: Mark O. Martin Guest: Marcy Balunas Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode An article on bacterial colonial variation during domestication, by Dr. Roberto Kolter and colleagues. The Tiny Earth Project to crowdsource new bacterial sources of antibiotic compounds. An overview of chemical ecology. Description of how analytical chemistry is used to investigate symbioses. A description of how MALDI is used to identify compounds. A description of how LC M/S is used to identify compounds. A description of some work done on tunicate-microbe associations by the Balunas lab. Dr. Jonathan Klassen collaboration. An article on ant based fungal farming. Dr. Spencer Nyholm collaboration. An article on the squid nidamental gland. Dr. Irene Newton collaboration. An article on bee associated microbes that protect against fungal infection. A video describing some of the work done by the Balunas laboratory on ant fungus farming with Dr. Klassen. Dr. Balunas faculty website. Balunas laboratory website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

Dr. Keith Ellis is a Scientist and Associate Professor of Medicinal Chemistry that is dedicating his time, energy, and talents to helping people recover from Long Covid. Dr. Ellis is using his knowledge, expertise, and experience in medicinal chemistry, pharmacology, and natural products to research the biological mechanisms that cause Long Covid and the potential therapeutic mechanisms that can help people recover. Combining this scientific work with his interest in entrepreneurship, Dr. Ellis has designed and brought to market a custom-formulated natural product supplement to help people recover from Long Covid. In 2023, Dr. Ellis founded Science-Driven Supplements and launched its first product: CircuGuard - a natural, herbal supplement to help people recover from Long Covid microclots. Dr. Ellis and Science-Driven Supplements are committed to creating custom-formulated solutions for people with Long Covid that are safe, inexpensive, accessible for everyone without a doctor's prescription, and available RIGHT NOW. Several more products targeting other underlying biological mechanisms of Long Covid are in the design phase and will be launched in the coming year. In parallel with his Long Covid research and work as Founder of Science-Driven Supplements, Dr. Ellis serves as an Associate Professor of Medicinal Chemistry conducting academic research in early lead discovery in the oncology field and teaching organic and medicinal chemistry to graduate students, professional students, and undergraduates. Dr. Ellis has published academic scholarly work in world-class scientific journals including: the Journal of Natural Products, ACS Medicinal Chemistry Letters, ACS Chemical Biology, Molecular Pharmacology, Oncotarget, Oncogene, Bioorganic & Medicinal Chemistry, and Cancer Biology & Therapy. Career Highlights: Founder - Science-Driven Supplements, LLC - 2023 Faculty PositionsVirginia Commonwealth University, Richmond, VAAssociate Professor of Medicinal Chemistry (with Tenure) - 2018-presentAssistant Professor of Medicinal Chemistry - 2008-2018 Education and Professional TrainingBA Cum Laude (Chemistry) - 1999 - Cornell University, Ithaca, NYPhD (Chemistry) - 2004 - University of Virginia, Charlottesville, VAPost-Doctoral Researcher - 2005-2006 - Department of Medicinal Chemistry, University of Kansas, Lawrence, KSResearch Associate - 2007-2008 - Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN Long Covid Research, Social Media Links, and LinkedIn Profile can be found at www.keithcellisphd.com.

Dr. Craig Svensson is a Dean Emeritus of Pharmacy and Professor of Medicinal Chemistry and Molecular Pharmacology at Purdue University, as well as an Adjunct Professor of Pharmacology and Toxicology at the Indiana University School of Medicine. He is also an elected Fellow of the American Association for the Advancement of Science and the American Association of Pharmaceutical Scientists. He's the authored over a hundred scientific publications and several books, including When the Hurt Won't Heal and the mini-book, Recreational Drug Use: A Biblical Perspective. He lives in West Lafayette, IN, and he's been married to his beautiful bride for 40 years.  To find out more about Dr. Craig, you can visit his website: http://www.craigsvensson.com or email him at svensson@purdue.edu . ------------------------------------------------   If you want to help us transform the lives of even MORE MEN for God's glory, please take a minute to leave us a helpful REVIEW on iTunes: http://www.rmcpodcast.com and SHARE this podcast with any young man (or men) you're mentoring or discipling. And make sure you don't miss an interview episode by signing up for our Man-to-Man eNewsletter at http://www.RealMenConnect.com, and grab your FREE copy of the Real Men Victory Tracker.    Talk with Dr. Joe 1-on-1: Are you stuck? Want to go to get your faith, marriage, family, career and finances back on track?  Then maybe it's time you got a coach. Every CHAMPION has one. Schedule an appointment to chat with Dr. Joe on how we can help you spiritually love and lead your family better and become the hero of your home.   Dr. Joe takes on only a few Breakthrough Calls each week to help you with your faith, marriage, work, and financial challenges.  The call is FREE, but slots are limited to ONE call only.  NO RESCHEDULES.  Just click on the link below and select the BREAKTHROUGH CALL option to set up an appointment: http://TalkwithDrJoe.com  If no slots are available, please check back in a week.   Also join us on: Join the Real Men 300: http://www.RealMen300.com Facebook Group: http://www.realmenuniversity.com/ YouTube: http://www.RealMenTraining.com Facebook: @realdrjoemartin Instagram: @realdrjoemartin Twitter: @professormartin

Some debate that synthetic organic chemistry strategies have become stale, but Dr. Todd Hyster of Princeton University's Hyster Lab disagrees.Todd fell in love with organic chemistry early in his education, but it wasn't until he got turned on to enzyme catalysis that he found his true calling. He's built a career using engineered enzymes to facilitate chemical transformations that would otherwise not be possible. Specifically, he and his team focus on photo-enzymatic catalysis where they use a combination of light and engineered proteins to drive new chemical transformations.Join us to learn about his work, the methods involved, and the types of transformations being accomplished, which is beyond enantioselective synthesis, by the way. This stimulating conversation delves into the tactical and philosophical aspects of the synthetic chemistry, enzyme catalysis, and even the realities of academic funding and industry collaboration. Related episodes: Season 3, Ep.2: Making impossible moleculesSeason 2, Ep.3: Rethinking catalysisBonus content!Access bonus content curated by this episode's guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.View the video of this episode on www.thermofisher.com/chemistry-podcast.A free thank you gift for our listeners! Request your free Bringing Chemistry to Life t-shirt on our episode website.Use code BCTLisn3R in September, and cHeMcas+ng in October We read every email so please share your questions and feedback with us! Email helloBCTL@thermofisher.com

Guest: Dr. Lynn Kirkpatrick Chief Executive Officer, Ensysce Biosciences Inc. Ticker: $ENSC (NASDAQ) Website: https://ensysce.com/ Bio: Dr. Lynn Kirkpatrick Chief Executive Officer, Ensysce Biosciences Inc. Dr. Kirkpatrick has focused her entire career on drug discovery and development. Former Professor of Chemistry and Biochemistry in Canada, she has been active in both the novel drug discovery as well as clinical development of drug candidates throughout her career. She co-founded three start-up companies and successfully brought three novel cancer drug candidates and two other drug candidates in pain and infectious diseases from bench into human clinical trials. Following the acquisition of the first company she co-founded, ProlX Pharmaceuticals, she became President and CEO of Ensysce Biosciences Inc. and took the company public in 2021. Now Dr. Kirkpatrick is guiding the clinical development of Ensysce's highly novel pain products, which use compelling chemical approaches to reduce abuse and overdose potential. Dr. Kirkpatrick received her PhD in Medicinal Chemistry from the University of Saskatchewan and completed a post-doctoral fellowship in Pharmacology at Yale University School of Medicine before returning to Canada where she spent 16 years in academia. She has published extensively in the area of targeted cancer drug discovery and development and holds numerous patents for novel drug candidates. Company Bio: Ensysce Biosciences is developing first-in-class and uniquely innovative solutions in oral drug delivery. Our proprietary TAAP™ and MPAR® technologies improve the care and safety of patients by preventing the possibility of both abuse and overdose of prescription drugs. Our mission is to revolutionize the safety and oral delivery of medicines for areas of high unmet need. --- Support this podcast: https://podcasters.spotify.com/pod/show/smartmoneycircle/support

Speakers' Profiles Vanessa Fairhurst (she/her) – Head of Community, PREreview ORCID ID: ⁠0000-0001-8511-8689⁠ Vanessa joined the PREreview team in November 2022. She studied her undergraduate degree in European Languages and Business Management before going on to study her Master's in Applied and Professional Ethics. Chad Sansing (he/him) –  Head of Product, PREreview ORCID ID: ⁠0000-0002-1472-1824⁠ Chad joined the PREreview team in late October 2022. Prior to joining PREreview, he worked for the Mozilla Foundation in a variety of roles, most recently as a program manager on the MozFest team. Dine Roseline Dzekem, Founder, Rwanda Preprint Club ORCID ID: ⁠0000-0002-8210-9258⁠ Miss Dine Roseline Dzekem is a public health professional and social scientist in her early career. She has a background in sociology and anthropology from the University of Buea-Cameroon (2016) and a Master's degree in public health from the University of Rwanda (2019). Lamis Yahia Mohamed Elkheir, Lecturer at the University of Khartoum and a Co-Director of the African Reproducibility Network (AREN). ORCID ID: 0000-0002-3516-334X Lamis Yahia Mohamed Elkheir is a Lecturer at the University of Khartoum and a Co-Director of the African Reproducibility Network (AREN). Currently finalizing her PhD in Medicinal Chemistry, Lamis also holds a Master of Science in Molecular Medicine and a Bachelor of Pharmacy. Ebuka Ezeike, Project Manager,  Access 2 Perspectives and  AfricArXiv ORCID ID: 0000-0003-3452-0306 Ebuka Ezeike is a physicist from the Federal University of Technology Minna, in Niger state, Nigeria. With a background in physics and over half a decade of experience as an educator in the field, Ebuka brings a wealth of knowledge to his endeavors. His expertise extends to freelance work, where he delivers writing services, including articles and blog posts. Additionally, he manages two academic podcast shows refining audio and video content, including transcriptions. #openaccess #research #openscience #preprint #peerreview Find more podcast episodes here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org/podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Host:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Dr Jo Havemann⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ORCID iD ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠0000-0002-6157-1494 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Editing: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ebuka Ezeike⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Music:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Alex Lustig⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, produced by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Kitty Kat ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ License:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Attribution 4.0 International (CC BY 4.0)   ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ At Access 2 Perspectives, we guide you in your complete research workflow toward state-of-the-art research practices and in full compliance with funding and publishing requirements. Leverage your research projects to higher efficiency and increased collaboration opportunities while fostering your explorative spirit and joy. Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

References Mini-Reviews in Medicinal Chemistry. 2022, Vol. 22, .#22. Brain Research 2024.April 15. Vol.1829.article 148793 Miller. S. 1968."Quicksilver Girl" https://open.spotify.com/track/1gXEKJBTx2sLhY3AWkG6tu?si=43c6fcd157e64f9d Bach, JS. 1735. The Italian Concerto & Partitas https://open.spotify.com/album/6Sbk3UQiGoIagydUA4URdi?si=rweGy9M1QBK3Y4ETha9rDw --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Meg welcomes Dr. Amy Hauck Newman, the Scientific Director and the Chief of Molecular Targets and Medications Discovery Branch and Medicinal Chemistry Section of the National Institute on Drug Abuse's Intramural Research Program also known as “NIDA” IRP. It is one of the 27 institutes and centers of the National Institutes of Health (NIH) and it is dedicated to understanding the causes, consequences and treatment of substance use disorders. On today's show, Dr. Amy Hauck Newman discusses her work in developing novel medications to treat substance use disorders. She explains the lengthy process of drug development and the importance of intellectual property and partnerships. Dr. Newman also highlights the role of AI and machine learning in healthcare and drug design. Amy shares her journey into chemistry and the challenges and rewards of starting and leading her own laboratory. The use of drugs like Ozempic is touched on as well as various aspects of substance use disorder and the challenges associated with its treatment. Amy talks about the challenges in treating cocaine and methamphetamine use disorder and the emotional weight of working in this field. Finally, the conversation gets into the challenges in engaging the pharmaceutical industry when it comes to fighting substance use disorders.Further Reading: Molecular Targets and Medications Discovery Branch at NIDA Presynaptic and Postsynaptic Mesolimbic Dopamine D3 Receptors Play Distinct Roles in Cocaine Versus Opioid Reward in MiceNIH Postbac ProgramNIH Summer Internship Program (SIP)Episode Credits: The Game-Changing Women of Healthcare is a production of The Krinsky Company. Hosted by Meg Escobosa. Produced by Meg Escobosa, Calvin Marty, Chelsea Ho, Medina Sabic, Markala Comfort, and Wendy Nielsen.Edited, engineered, and mixed by Calvin Marty. All music composed and performed by Calvin Marty. ©2024 The Krinsky Company

Bioconjugation of antibodies to drugs via chemical linkers is how antibody drug conjugates (ADCs) are made. We're joined by Matt Giese, Senior Scientist at Vector Laboratories, who talks us through the complex chemistry options and biodesign considerations that have to be considered and balanced when making a successful ADC.How does one build the skillset to work in biodesign of ADCs you might ask? Well, Matt's career path might not provide a clearcut roadmap like you might hope. That's because Matt started his career as an auto mechanic, moved into art, went back to auto mechanics, worked as baggage handler and as a construction worker, all before ever finding chemistry. If you think that's a convoluted path, just wait to hear about his academic and professional work journeys.  You'll revel in following this journey, and in the lessons and diverse skills learned along the way. Join us to hear it yourself, from who might just be the most interesting man in chemistry!Related episodes:Season 5, Ep.7: The life-altering impact of one chemist's sabbaticalSeason 2, Ep.1: Chemistry: a modern American dreamSeason 3, Ep.5: On the COVID pill and other process chemistry tales Bonus content!Access bonus content curated by this episode's guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.View the video of this episode on www.thermofisher.com/chemistry-podcast. A free thank you gift for our listeners! Request your free Bringing Chemistry to Life t-shirt on our episode website.Use Podcast Code: LabRatsRul3 in July or OchemRcks in August. We read every email so please share your questions and feedback with us! Email helloBCTL@thermofisher.com

Parkinson's disease is a neurodegenerative disorder characterized by uncontrollable movements, stiffness, and cognitive decline. Curious? Come learn more! Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below. National Institute on Aging. Parkinson's Disease: Causes, Symptoms, and Treatments. National Institute on Aging. Hogg E, Frank S, Oft J, Benway B, Rashid MH, Lahiri S. Urinary Tract Infection in Parkinson's Disease. Journal of Parkinson's Disease. 2022;12(3):743-757. ‌Yu J. Stages of Parkinson's | Parkinson's Foundation. www.parkinson.org. Published 2022. ‌Zhang ZX, Dong ZH, Román GC. Early Descriptions of Parkinson Disease in Ancient China. Archives of Neurology. 2006;63(5):782. ‌2-Minute Neuroscience: Direct Pathway of the Basal Ganglia. www.youtube.com. 2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia. www.youtube.com. ‌Thanvi B, Lo N, Robinson T. Levodopa-induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment. Postgraduate Medical Journal. 2007;83(980):384-388. Zhang JF, Wang XX, Feng Y, Fekete R, Jankovic J, Wu YC. Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies. Frontiers in Psychiatry. 2021;12. Hisahara S, Shimohama S. Dopamine Receptors and Parkinson's Disease. International Journal of Medicinal Chemistry. 2011;2011:1-16. Houston. Tmc.edu. Published October 20, 2020. https://nba.uth.tmc.edu/neuroscience/m/s3/chapter04.html‌Ovallath S, Sulthana B. Levodopa: History and Therapeutic Applications. Annals of Indian Academy of Neurology. 2017;20(3):185-189. ‌Levodopa | Parkinson's Foundation. www.parkinson.org. https://www.parkinson.org/living-with-parkinsons/treatment/prescription-medications/levodopa‌Kelly MJ, Baig F, Hu MTM, Okai D. Spectrum of impulse control behaviours in Parkinson's disease: pathophysiology and management. Journal of Neurology, Neurosurgery & Psychiatry. 2020;91(7):703-711. ‌Gerfen CR, Surmeier DJ. Modulation of Striatal Projection Systems by Dopamine. Annual Review of Neuroscience. 2011;34(1):441-466. ‌Sayare S. The Woman Who Could Smell Parkinson's. The New York Times. https://www.nytimes.com/2024/06/14/magazine/parkinsons-smell-disease-detection.html. Published June 14, 2024. ‌Blandini F, Nappi G, Tassorelli C, Martignoni E. Functional changes of the basal ganglia circuitry in Parkinson's disease. Progress in Neurobiology. 2000;62(1):63-88. ‌Lanciego JL, Luquin N, Obeso JA. Functional Neuroanatomy of the Basal Ganglia. Cold Spring Harbor Perspectives in Medicine. 2012;2(12):a009621-a009621. Climate ConfidentWith a new episode every Wed morning, the Climate Confident podcast is weekly podcast...Listen on: Apple Podcasts SpotifySupport the Show.

Iktos is an innovative company specializing in the development of artificial intelligence solutions applied to chemical research and new drug design, enabling major productivity gains in upstream pharmaceutical R&D.

Michael Medeiros is a Presenter and Content Creator who left Clongowes in 2018. Having attained a BSc in Chemical Sciences with Medicinal Chemistry, Mick decided to go down a different route and pursue his passion for social media. Having worked with many notable brands such as BBC, Virgin Media, Premier League, Adidas, EA Sports and LADBible to name a few, Mick's contagious energy has enabled him to interview and create content with some high profile individuals such as Ian Wright, Rio Ferdinand, Jazzy, Eddie Hearn and KSI amongst many others. As a result of his achievements, Mick was nominated and shortlisted for 2 Awards (Content Creator of the Year & Personality of the Year) at this year's Black & Irish Gala Awards powered by RTE. Today, Mick speaks with us to reminisce about his time in Clongowes and how it's played a massive part in helping him become the man he is today. --- Send in a voice message: https://podcasters.spotify.com/pod/show/portraitsofclongowes/message

Dr. Jonathan (Josh) Bloom, ACSH's Director of Chemical and Pharmaceutical Science, earned his Ph.D. in organic chemistry at the University of Virginia, followed by postdoctoral training at the University of Pennsylvania. His first career was in drug discovery research, mostly at Wyeth. During this time he participated in research in a number of therapeutic areas, including diabetes and obesity, new antibiotics, HIV/AIDS, and hepatitis C. His group discovered the novel antibiotic Tygacil®, which was approved by the FDA for use against resistant bacterial infections in 2005. He is the author of 25 patents, and 35 academic papers, including a chapter on new therapies for hepatitis C in Burger's Medicinal Chemistry, Drug Discovery, and Development, 7th Edition (Wiley, 2010). Dr. Bloom joined the American Council on Science and Health in 2010 as Director of Chemical and Pharmaceutical Sciences. The articles featured are: DEA Chasing Its Tail Again: This Time, It's 'Synthetic Cannabinoids' https://www.acsh.org/news/2023/12/20/dea-chasing-its-tail-again-time-its-synthetic-cannabinoids-17523 Tylenol Plus Advil Combo: Innovation Or Exploitation? https://www.acsh.org/news/2023/12/28/tylenol-plus-advil-combo-innovation-or-exploitation-17549   #ACSH #Josh #Bloom #DEA #pharmaceutical #industry #American #Council #Science #Health

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Diana Kraskouskaya, co-founder and CEO of Dalriada Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Diana, covering: Exactly what ‘the Toronto paradox' is... How two, seed-funded failures, led to identifying a gap in the market along with access to a rich talent pool The challenges and realities of starting, growing and scaling a CRO business to over 100 people Advice for other females looking to forge an entrepreneurial career in the drug development space Diana brings years of leadership and hands-on cross-disciplinary biotech and drug discovery experience spanning areas of company building, scientific & IP program strategy, and operations. She completed an Honors BSc Degree in Molecular Biology and PhD in Medicinal Chemistry from the University of Toronto and is a co-founder of two other biotechs, which have raised > $10 M in VC funding. Diana is the recipient of several entrepreneurship awards, including the RBC Prize for Innovation & Entrepreneurship and the 2018 MNP Future Leaders Awards. Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating! Molecule to Market is sponsored and funded by ramarketing, an international marketing, design, digital and content agency helping companies differentiate, get noticed and grow in life sciences.  

Imagine being a detective in the world of molecules, uncovering secrets that could save lives. That's what medicinal chemistry does—it helps us design drugs that target diseases like puzzle pieces fitting together. On this exciting episode of Let's Talk Chemistry edited by Presley Vu, hosts Yeongseo Son and Jason Lu talk about their interview with Dr. Donna Huryn, Professor of Practice at the University of Pennsylvania. Dr. Huryn is also a co-founder of Empowering Women in Organic Chemistry, and she gives us more insight about this initiative. We hope you enjoy! If you would like to know more about Dr. Donna Huryn, you can reach her by email at huryn@sas.upenn.edu

Welcome to the last episode of the year for our podcast, Under the Surface! In this episode, A CHRIStmas Carol, we conjure up some jovial spirits of the past as our Super Senior co-host Dave grills his colleagues on the founding, early years, and development of the Chemical Computing Group. As you'll hear, Dave manages to make Research Group Leader, Anna Lin, and his regular co-host, Chris Williams, feel deeply uncomfortable and encourages them to step out of their inherent Canadian humility and embrace the fact that they contributed to the building of a thing that is still going strong - 30 years on! Reminiscences are shared, the field is reflected upon, and famous Canadians are listed. It is, dear listener, a roller coaster of an emotional ride.  

Artificial intelligence has the power to transform the way researchers study bacteria and develop new treatments – and we're already seeing the benefits in healthcare. In part three, host Jeremiah Owyang and expert guests shed light on how AI expedites and enhances analyses, revolutionizing the search for new antibiotics. The benefits of AI extend to analyzing bacterial DNA, uncovering vulnerabilities, and potentially predicting bacterial evolution. This innovative technology aids scientists in pinpointing the most promising antibiotic candidates from a sea of possibilities and helps to streamline drug development.Featured Guests:Adrian Egli, Director, Institute of Medical Microbiology, University of ZurichLei Zhang, Executive Director of Medicinal Chemistry, Pfizer Medicine DesignMarinka Zitnik, Assistant Professor, Department of Biomedical Informatics, Harvard Medical School; Co-founder, Therapeutics Data Commons Season 3 of Science Will Win is created by Pfizer and hosted by Jeremiah Owyang, entrepreneur, investor, and tech industry analyst. It's produced by Wonder Media Network.

Check out the next episode of our podcast, Under the Surface! In episode 2, Fun with Pharmacophores, we talk to Dr. Scott Rowland about pharmacophore-based techniques and their role in understanding receptor–ligand interactions, and ultimately, how they contribute to the design of new drugs. Recently retired, following decades in the pharmaceutical industry, Scott tells us about his journey through the field and his deep appreciation for collaborative science. Scott hasn't completely hung up his abacus just yet though, and he tells us about his recent consultative adventures too! How have we managed to fit all of this in one episode? It's a mystery.

An estimated 3 million Americans use kratom products for recreational purposes, in self-treatment of opiate addiction, and to manage pain. Yet, our scientific understanding of its safety, efficacy, and potential for addiction is still poorly understood. With new data emerging each year, scientists are starting to gain a better picture of the full spectrum of risks and benefits of this SE Asian medicinal herb. Our guest this week, Dr. Christopher McCurdy, is an internationally recognized expert on kratom. Chris is a Professor of Medicinal Chemistry and Pharmaceutics at the University of Florida College of Pharmacy, where he also directs the UF Translational Drug Development Core. We address questions like: What is kratom? Where does it come from and how does its traditional use differ from the ways it is consumed in the USA? What are the major active compounds found in kratom and how much variation is there in different products? What are the side effects of chronic versus acute use of kratom? And are there any drugs you should avoid taking in combination with kratom? #kratom #MedicinalPlants #Pain #Addiction #tea #Herbs #HerbalSafety #Stimulant #Science #foodiepharmacology #ChristopherMcCurdy 

Dr Jill Collins holds a Doctorate in Medicinal Chemistry from the University of Illinois at Chicago and has over 17 years of scientific and strategic marketing experience. Following her postdoctoral position in neuroscience, she moved into biotechnology and held leading roles at biotech companies.Jill is a visionary for branding and activation in the healthcare and biotech industries. As CEO and Chief Strategy Officer of Audacity Health, she has led the company to significant growth over the last six years. She recently won the CEO of the year award from the San Diego Business Journal for her leadership in helping Audacity thrive.Jill has been an exemplary leader at Audacity, driving growth and success for the company. Under her leadership, the team has experienced 40% growth from Jan 21 to July 22, added paid media capabilities and a new PR offering, and maintained strong client retention. Under her leadership, Audacity has also gone from generating just under a million dollars in 2013 to $2 million in 2014 to $6.5 million in 2021.Jill is committed to making a difference to the lives of her employees and the community. She introduced Audacity Health's charitable contributions program in 2021, with several charitable contributions that Audacity employees are passionate about supporting. In addition, she donates her time and resources to several other local organizations, including participating in beach clean-ups on Saturdays through The 'Purpose First Beach Clean-ups' organization.Jill is an influential leader and a fantastic role model for all women in business. Through her strategic leadership and dedication to her work, Jill has significantly impacted the healthcare industry. Coming from a scientific background, Jill has had to manage the difficult transition from the lab into the business world and learn how to navigate corporate dynamics as a female in several companies dominated by male leadership.In this episode, Jill and I chat about:Her leadership roles Her leadership style Her leadership journey The leaders that helped her rise The challenges she faced on her journey How she navigated those challenges How she thinks you can become a strong and kind leader Her ‘take home' leadership messages for the listeners, and What she is currently excited to be working on.Jill can be found and/or contacted via the following online platform addresses:jill.collins@audacityhealth.comContact form via www.audacityhealth.comhttps://www.linkedin.com/in/jillcollinsphd/https://www.linkedin.com/company/audacity-marketing-advertising-for-health-and-science-brands/Please reach out to Dr Harrison for individual coaching and/or organisational training via dr.adam@coachingmentoringdoctors.com.His web address and social media profile links / handles include:www.dradamharrison.comhttps://www.linkedin.com/in/dradamharrison/www.youtube.com/c/DrAdamPhysicianCoachhttps://www.facebook.com/coachingmentoringdoctors/https://www.instagram.com/dradamharrison/https://www.tiktok.com/@physiciancoachHe has co-written a new online course entitled ‘How to be Assertive, Maintain Boundaries, and Say “No!”‘ which can be accessed instantly here for only £55/$70:https://tenminutemedicine.podia.com/burnout-to-brilliance-assertiveness-and-saying-no

Rodri is a versatile professional, fulfilling roles as a Psychedelic Creative Coach, Development Lab Supervisor, science journalist, artist, and former educator. With a diverse skill set encompassing molecular biology, pharmacology, education, sculpture, music production, and painting, Rodri brings a unique fusion of scientific knowledge and artistic expression to his work. Holding a Master of Science in Medicinal Chemistry specializing in psychedelic pharmacology, Rodri's research and thesis on psychedelics were awarded the highest honors by his university. As a creative, Rodri is a multidisciplinary artist. He is an experimental electronic musician who goes under the stage name Rodri XO, a sculptor, painter, and collage artist. He is also the visionary founder of The Return of Saturn, an inclusive music festival that celebrates the talent of queer and BIPOC artists in Houston, Texas.Guided by a passion for empowering others, Rodri will serve as a Psychedelic Creative Coach on Bonfire.  Bonfire is Psychedelic Spotlight's psychedelic community, which offers an educational foundation about psychedelics, online courses, weekly facilitator group meetings and private one-on-one psychedelic facilitator sessions.Through Bonfire's “Microdose for Creativity” course, Rodri will be helping individuals harness the transformative potential of psychedelics to enhance their creativity and personal growth. His course will focus on four topics: finding your voice, unearthing inspiration, psychedelic flow state, and integration.✨You can find more information on Rodri's Bonfire course at: https://psychedelicspotlight.com/microdose-for-creativity/✨You can keep in touch with Rodri over on Instagram: https://www.instagram.com/areyoustilldepressed/✨You can listen to Rodri's music over on Soundcloud: https://soundcloud.com/whoisrodrixo

Carolyn Straub moderates a thriving online community for those interested in SMART on the social media platform Reddit. She enjoys helping others engage around how much SMART's tools and resources help those seeking recovery from addiction. In this podcast, Carolyn also shares her personal journey of recovery, which she wrote about in the Journal of Medicinal Chemistry in the essay Mind On Fire.     

y'all… even we aren't ready for this superstar… Dr. Courtney Law is a career scientist with remarkable achievements that exemplify her dedication to impacting human health. Law received her B.S. in Chemistry & Ph.D. in Pharmaceutical Sciences and Medicinal Chemistry & Natural Products from the University of North Carolina at Chapel Hill. after completing her postdoctoral fellowship at North Carolina Central University, she worked as a Tech Transfer intern at North Carolina State University. currently, Dr. Law leads Biolocity, where she “help[s] all Emory University and Georgia Institute of Technology faculty develop new biomedical innovations with commercial potential.” we are humbled and honored to be able to discuss Dr. Law's current work at Biolocity and her passion for human health in this episode!We appreciate & cherish Suna Lumeh for cohosting this interview. She is deeply connected to Atlanta's life science ecosystem and is a driver of growth. Learn more about her here: https://www.portalinnovations.com/team-page/

In this episode, I engage my most frequent guest so far in a conversation about his experience as a first year Chemistry and Biotechnology educator at the high school level. I never anticipated that I would be a guest in the position of an educator; but his high school and college experiences prepared him to change paths and take on a teaching career. Malik McFarlane received a Bachelor of Science with Honors in Chemistry with a Concentration in Medicinal Chemistry & Drug Discovery from Wake Forest University. He is very passionate about making science - particularly chemistry - more accessible for all students regardless of their background and previous experiences with Science, and is excited to find a way to achieve that in the culture in his classroom. In part 2, we will explore lessons and his future plans. Theme Song: Vocals - Shevaughn James; Music - Malik McFarlane; Lyrics - Maxine McFarlane & Shevaughn James

Listen to part 1 of DPF's interview with Dr. Josh Bloom. Why are so many pain patients put on Gabapentin? Does it work? Why are so many being prescribed Gabapentin all of a sudden? What are some of the possible side effects? Listen to some patient stories about Gabapentin. Stay tuned for Part 2 with Josh Bloom. Josh Bloom's bio: "Director of Chemical and Pharmaceutical Sciences Dr. Josh Bloom earned a Ph.D. in organic chemistry from the University of Virginia, followed by postdoctoral training at the University of Pennsylvania.He worked for more than two decades as a research chemist for Lederle Laboratories, which was acquired by Wyeth in 1994, which itself was acquired by Pfizer in 2009. During this time he worked in a number of therapeutic areas, including diabetes and obesity, antimicrobial agents, HIV/AIDS, hepatitis C, and oncology. His group discovered the novel antibiotic Tygacil®, which was approved by the FDA for use against resistant bacterial infections in 2005. He is the author of 25 patents, and 35 academic papers, including a chapter on new therapies for hepatitis C in Burger s Medicinal Chemistry, Drug Discovery and Development, 7th Edition (Wiley, 2010), and has given numerous public lectures on how the pharmaceutical industry really works. Dr. Bloom joined the American Council on Science and Health in 2010 as ACSH s Director of Chemical and Pharmaceutical Sciences, and has written more than 20 op-eds, which have appeared in major publications, including The Wall Street Journal, Forbes, The New York Post, National Review Online and Medical Progress Today. Dr. Bloom is a regular contributor to Science 2.0, where he writes on topics related to the pharmaceutical industry, medicine and junk science. In this episode, we included quotes from two ACSH podcasts. They are: Podcast: Neurontin — The Lousy Opioid Alternative; Twitter Censors ACSH Podcast: Tylenol After Surgery is Useless Dr. Josh Bloom's articles about Gabapentin: The Devil You Know - Neurontin's Massive Flop As An Opioid Alternative Neurontin: The Darling Of The Anti-Opioid Crowd. But Does It Work? Neurontin: Over-Hyped And Underwhelming Source of graph showing opioid prescribing is down to 1992 level Other patient comments about Gabapentin experiences. Please join this FB group in order to view this post, since it is a closed group. DPF's Patreon page announcement! Disclaimer: The information that has been provided to you in this podcast is not to be considered legal or medical advice. --- Send in a voice message: https://podcasters.spotify.com/pod/show/the-doctor-patient-forum/message Support this podcast: https://podcasters.spotify.com/pod/show/the-doctor-patient-forum/support

Today's episode is sponsored by my friends at Paleovalley.   Make sure to support this podcast and head over to Paleovalley.com/NwJ and use code NWJ to get 15% off your first order._____I'm excited to sit down with Dr. Joseph Musto. We talk about MARCoNS, MARCoNS treatments and much more. Make sure to listen to the full interview to learn more.Dr. Joseph Musto is the President, Director of Laboratory Medicine, Medical Director and Founder of Microbiology Dx.  Dr. Musto has been involved in laboratory medicine and methods development for clinical testing for over 40 years, with more than 20 publications and 7 issued patents. Dr. Musto earned a B.Sc. in Chemistry, M.Sc. in Organic and Physical Chemistry, the equivalent of an M.Sc. in Biomedical Science, and a Doctorate in Medicinal Chemistry. Dr. Musto is a Board Certified Clinical Laboratory Director, and spent 10 years of pre-and post-doctoral training in clinical laboratory science before establishing his first clinical pathology laboratory in 1979.  We discuss the following:What is MARCoNS (Multiple Antibiotic-Resistant Coagulase Negative Staph)?MARCoNS symptomsMARCoNS in the oral cavity Oral microbiomeMARCoNS in petsHow to test for MARCoNSMARCoNS treatmentsOver-the-counter treatmentsSilver toxicityCleaning the bathroom with hydrogen peroxideWhere to find Dr. Joseph Musto_____RESOURCESMARCoNS Testing: https://www.nutritionwithjudy.com/shopping/functional-tests/marcons-testingMicrobiology Dx: https://www.microbiologydx.com/ ____CHECK OUT MY BOOK, Carnivore CureSIGN UP FOR MY WEEKLY NEWSLETTER_____ ADDITIONAL RESOURCESNutrition with Judy ArticlesNutrition with Judy ResourcesCutting Against the Grain Podcast_____ FIND ME

Synopsis: Prakash Raman, Ph.D., is the President and CEO of Ribon Therapeutics, a clinical stage biopharmaceutical company pursuing the development of novel small molecules targeting stress support pathways in cancer and inflammation. A medicinal chemist by training, Prakash discusses his professional development and the evolution of his strategic thinking as he went from chemist, to project management, to business development, to now CEO. He shares his advice for scientists in biotech and pharma and the best method he's found for communicating with and motivating his team. He also discusses the inherent risk involved in biotech and his perspective on how failure can be a teaching moment. Interested to learn more about Ribon? Check out this episode featuring Heike Keilhack, CSO: https://bit.ly/3yeXUmi Biography: Prakash Raman, Ph.D. has served as Ribon's president, chief executive officer and board member since February 2022. Dr. Raman brings to Ribon decades of biopharmaceutical business development and executive leadership experience, blending his scientific background, program and portfolio management and strong business development experience. Prior to joining Ribon, he served as Senior Partner, Chief Business Development Officer at Flagship Pioneering from October 2019 to February 2022, where he leveraged the platforms and assets in Flagship's network to generate opportunities for significant value creation. Prior to Flagship, Dr. Raman spent nearly fourteen years at Novartis, most recently as Vice President, Global Head of Novartis Institutes for Biomedical Research (NIBR) Business Development and Licensing (BD&L). During his time at Novartis, Dr. Raman was instrumental in forging key collaborations in immuno-oncology, executing many out-licensing opportunities and guiding the acquisitions of Advanced Accelerator Applications, Endocyte, IFM Tre and Selexys. In addition, he has led cross-functional drug discovery and early development project teams that successfully progressed compounds to clinical testing in patients. Prior to Novartis, Dr. Raman spent six years as a Senior Scientist at Millennium Pharmaceuticals and two years as a post-doctoral fellow at The Scripps Research Institute. He completed his undergraduate work at the Indian Institute of Technology, Bombay, and received his Ph.D. in Organic and Medicinal Chemistry from the University of Wisconsin-Madison.

Verseon is delighted to announce European Journal of Medicinal Chemistry has published its Paper on the treatment of Cardiovascular Disease.

Today I share a few of the many discoveries presented by Christopher R. McCurdy, Ph.D., F.A.A.P.S, professor and researcher at the University of Florida's College of Pharmacy, Medicinal Chemistry department. In it, he talks about a number of different recent discoveries with kratom research and it blew my mind away with all of the interesting mysteries we have yet to uncover. The presentation is available to watch on the National Research and Innovation Agency's (BRIN) YouTube Channel. BRIN is a state institution of the Republic of Indonesia, which was formed to strengthen the national research and innovation ecosystem through research, development, study and implementation. (Sources in this episode can be found below): https://www.youtube.com/watch?v=6Q4IgaD7SnE !!! GET 15% OFF ALL Happy Hippo KRATOM PRODUCTS !!! Visit https://happyhippoherbals.com/r?id=ul2k1j and use the coupon code EVERYTHINGKRATOM at check out! !!! Get 25% off orders from ETHA Natural Botanicals!!! Visit https://ethalivefully.com/discount/EVERYTHINGKRATOM?aff=243 and use the coupon code EVERYTHINGKRATOM at check out! Please support this podcast here! https://www.paypal.me/everythingkratom Or make a small monthly donation here! https://anchor.fm/everything-kratom/support Kratom is NOT intended to diagnose, treat, cure, or prevent any disease or condition. No content in this or any episode of The Everything Kratom Podcast recommends or suggests that anyone should use kratom or any other substance in any way whatsoever. Available wherever you get your podcasts: YouTube Channel: https://www.youtube.com/channel/UCUsCC1nBchi_xMX9wRyQ_nA Anchor - https://anchor.fm/everything-kratom Spotify - https://open.spotify.com/show/2fO3Xsx1BbNUs2rpXiQs3s Google Podcasts - https://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy82OWUxMzZjNC9wb2RjYXN0L3Jzcw== Apple Podcasts - https://podcasts.apple.com/us/podcast/everything-kratom/id1584592399 Pocket Casts - https://pca.st/mql8q14u RadioPublic - https://radiopublic.com/everything-kratom-WzkkBK Overcast - https://overcast.fm/itunes1584592399/everything-kratom Reason - https://reason.fm/podcast/everything-kratom?user=16e32b81-d623-4dcd-a000-623566fdc41a Website: https://everythingkratom279311648.wordpress.com Thank you all so much for listening! --- Send in a voice message: https://anchor.fm/everything-kratom/message Support this podcast: https://anchor.fm/everything-kratom/support

First I had created this channel just to share Multiple Choice Questions related to Medicinal Chemistry. Now, I am sharing Powerpoint lecture videos including animation especially related to Medicinal Chemistry. If you have any queries or suggestions you can contact me at lecturesofpharmacy@gmail.com [https://www.youtube.com/c/PharmacyLectures](https://www.youtube.com/c/PharmacyLectures) [https://the-pharmacy-place.getlearnworlds.com](https://the-pharmacy-place.getlearnworlds.com) https://youtu.be/aXxRqqqHbFw https://rumble.com/v1nhnb2-pharmacy-lectures.html #learn #pharmacy #presentations --- Send in a voice message: https://anchor.fm/jack-bosma3/message Support this podcast: https://anchor.fm/jack-bosma3/support

Pyrlcasts, brought to you by Pyrls.com! We take a closer look at interesting and relevant clinical topics related to pharmacotherapy. Want to learn more clinical pearls? Boost your clinical confidence? Visit and sign-up for an account at pyrls.com to get over 10 high-quality charts absolutely FREE! Episode References: Froestl W, Muhs A, Pfeifer A. Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors. J Alzheimers Dis. 2012;32(4):793-887. doi:10.3233/JAD-2012-121186 Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev. 1992;17(2):139-170. doi:10.1016/0165-0173(92)90012-b Institute of Medicine (US) Committee on Military Nutrition Research. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington (DC): National Academies Press (US); 2001. 2, Pharmacology of Caffeine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK223808/ Hansen PB, Schnermann J. Vasoconstrictor and vasodilator effects of adenosine in the kidney. Am J Physiol Renal Physiol. 2003;285(4):F590-F599. Faudone G, Arifi S, Merk D. The Medicinal Chemistry of Caffeine. J Med Chem. 2021;64(11):7156-7178. doi:10.1021/acs.jmedchem.1c00261oi:10.1152/ajprenal.00051.2003 Gessi S, Merighi S, Fazzi D, Stefanelli A, Varani K, Borea PA. Adenosine receptor targeting in health and disease. Expert Opin Investig Drugs. 2011;20(12):1591-1609. doi:10.1517/13543784.2011.627853 Spilling the Beans: How Much Caffeine is Too Much? United States Food and Drug Administration. Updated Dec 12, 2018. Accessed Aug 4, 2022. https://www.fda.gov/consumers/consumer-updates/spilling-beans-how-much-caffeine-too-much#:~:text=For%20healthy%20adults%2C%20the%20FDA,it%20(break%20it%20down). Brain Basics: Understanding Sleep. National Institute of Neurological Disorders and Stroke. Updated July 25, 2022. Accessed Aug 4, 2022. https://www.ninds.nih.gov/health-information/patient-caregiver-education/brain-basics-understanding-sleep

In this week's episode we dig into the microbiome with world renowned expert Dr. Ghannoum.  We chat about what the microbiome is, and that is not JUST bacteria.  How the microbiome not just in your gut, the health implications of these colonies, what disrupts them and what feeds them.   No one has done more research of the microbiome that Dr G., and he continues to research more everyday.Dr G is the Co-Founder and Chief Scientific Officer, BiohmHealthReceived an MSc in Medicinal Chemistry and his PhD in Microbial Physiology from the University of Technology in Loughborough, England, and an MBA from the Weatherhead School of Management at Case Western Reserve University, Cleveland, OH. A tenured Professor and Director of the Integrated Microbiome Core and Center for Medical Mycology, and Case Western Reserve University and University Hospitals Cleveland Medical Center. Published > 450 peer reviewed publication and 6 scientific books, and was on the top 1% of cited Scientists Worldwide Established a multidisciplinary Center of Excellence that combines basic and translational research that spans test tube to the bedside capabilities. He pioneered studies on the fungal communities residing in and on our body and coined the term ‘Mycobiome”. Awarded the Rhoda Benham Award from the MMSA, and the Freedom to Discover Award from Bristol-Myers Squibb for his outstanding and meritorious contributions to the fields of medical mycology and microbial biofilms. Fellow of the Infectious Disease Society of America (IDSA), past President of the Medical Mycological Society of the Americas (MMSA). Fellow of the American Academy of Microbiology (FAAM), and the European Society of Clinical  Microbiology and Infectious Diseases (FESCMID).An entrepreneur-scientist who has launched a number of companies focused on the treatment of biofilm infections, as well as microbial dysbiosis.

An internationally recognized expert on edible & medicinal wild plants, Mark “Merriwether” Vorderbruggen, Ph.D. half-jokingly describes himself as a “scientist raised by wolves.” Merriwether's brain earned him a master's in medicinal chemistry and a Ph.D. in physical organic chemistry, but his heart has always driven him to learn and share the secrets of nature to anyone ready to hear them. His love of nature was instilled in him by his parents and grandparents, who used nature's gifts to feed and care for the family. Endless hours of his childhood were spent in the wild…and this continues on to today, where he leads plant walkabouts across Texas, teaching people the ethical way to gather food and medicine. This deep study of plants and their properties caused people to call him “Merriwether,” after the famed botanist/explorer Meriwether Lewis. His professional chemistry career was that of a healer of the Earth, developing ways to safely and cleanly interact with its gifts. Among the results of that time are fifteen patents using natural plants, microorganisms, and oyster chemistry to make the world safer. Because of his past, he was chosen to be the medicine man for Medicine Man Plant Co., a 3-person company devoted to bringing back the medicinal plants, mushrooms, and movements our ancestors evolved using. Merriwether's study of early people, combined with his scientific understanding of the human body, has led him to believe many modern health issues are because we no longer interact with nature the way we evolved. Just as our diet needs critical vitamins and minerals for proper health, we also need certain physical, mental, and social actions to avoid “lifestyle” health problems. Helpful Links Website www.medicinemanplantco.com Facebook: www.facebook.com/medicinemanplantco Instagram: www.instagram.com/mmplantco TikTok: @dr.merriwether Book Mentioned Peterson Field Guide To Medicinal Plants & Herbs Of Eastern & Central N. America: Third Edition https://amzn.to/3zczyLj {affiliate link} --- Send in a voice message: https://anchor.fm/chatsfromtheblogcabin/message

In this episode, we “deep dive” into diltiazem, describing its most important drug facts, pharmacology and medicinal chemistry, pharmaceutics, AB compatibility, and important medication safety issues. Key Concepts Diltiazem is a non-dihydropyridine calcium channel blocker (CCB). This type of CCB reduces both heart rate and blood pressure whereas dihydropyridine CCBs only reduce blood pressure. Diltiazem has numerous dosage forms (IV, immediate release tablets, and extended-release products). Extended-release products are always dosed once or twice daily. Historically there were a significant number of extended-release capsules with a variety of brand names and AB-compatibility. Today, only a few branded products still exist in the US market (Cardizem CD, Cartia XT, Cardizem LA, Tiazac, Taztia XT). The FDA Orange Book describes “AB” compatibility, which outlines whether one formulation is therapeutically equivalent to another formulation. Depending on state law, pharmacists can use AB compatibility codes to automatically substitute formulations without notifying the prescriber. The numerous dosage forms of diltiazem is a medication safety issue. Remember that immediate release diltiazem is always dosed TID/QID (3-4 times per day) whereas extended-release formulations are always dosed once daily. A twice-daily extended-release product was previously on the market but has since been discontinued.

Dr. Josh Bloom is an organic chemist who debunks Junk Science in his work with the American Council on Science. Hear what he has to say about opioids and pain, fentanyl, methamphetamine, benzodiazepines, and cannabis. Do Dr. Lev and Dr. Bloom agree or disagree on issues of addiction? You judge. Dr. Josh Bloom, ACSH's Director of Chemical and Pharmaceutical Science, earned his Ph.D. in organic chemistry at the University of Virginia, followed by postdoctoral training at the University of Pennsylvania. His career 20+ year first career was drug discovery research at Wyeth. During this time he participated in research in a number of therapeutic areas, including diabetes and obesity, new antibiotics, HIV/AIDS, and hepatitis C. His group discovered the novel antibiotic Tygacil®, which was approved by the FDA for use against resistant bacterial infections in 2005. He is the author of 25 patents, and 35 academic papers, including a chapter on new therapies for hepatitis C in Burger's Medicinal Chemistry, Drug Discovery, and Development, 7th Edition (Wiley, 2010). Dr. Bloom, who joined the American Council on Science and Health in 2010 as Director of Chemical and Pharmaceutical Sciences, has published more than 75 op-eds in numerous periodicals, including The Wall Street Journal, Forbes, New Scientist, The New York Post, National Review Online, The Boston Herald, The Baltimore Sun, The Chicago Tribune, and The New York Daily News. He has also done numerous radio and television shows and podcasts on topics related to drugs, chemicals, and most importantly, the plight of pain patients – the innocent victims of the misguided war on opioid drugs. He is now recognized as an expert in government opioid policy and was the first journalist to write a nationally published opinion piece about the unintended consequences of a governmental crackdown on prescription pain medications (New York Post, 2013). Since that time he has published more than 20 op-eds in regional and national newspapers on different aspects of the crisis. He was also the first writer (2016) to study, dissect and ultimately debunk the manipulated statistics used by the CDC to justify its recommendations for opioid prescribing, which have resulted in Draconian requirements for prescribing pain medications as well as government-mandated, involuntary tapering of patients receiving opioid treatment, both of which have caused great harm and needless suffering to chronic pain patients. His 2016 article, "Six Charts Designed to Confuse You," is considered to be the seminal work on CDC deception and has been adopted by patient advocacy groups. It has been sent to governors, senators, and state legislatures.

More than 50 years after emerging as a potential treatment for anxiety and depression, addiction, post-traumatic stress disorder and other chronic illnesses, psychedelics appear to be making a comeback. But where does the research stand currently on psychedelics and what do we really know about how these compounds may affect the brain?With the number of people living with mental health conditions on the rise and the re-emergence of psychedelics as a possible therapy, this topic is very timely. Some may call it a “perfect storm” – one the medical and scientific communities will need to carefully navigate, in order to tap the potential of psychedelics, safely and cautiously.Featuring:Dr. Susan Abbey is Psychiatrist-in-Chief at the University Health Network (UHN), and a Clinician Investigator with the Toronto General Hospital Research Institute.  She is also a Professor in the Department of Psychiatry at The University of Toronto and the inaugural Director of the Nikean Psychedelic Psychotherapy Research Centre at UHN.Dr. Lakshmi Kotra is a Medicinal Chemist and Senior Scientist with Krembil Brain Institute and a Professor of Medicinal Chemistry at The University of Toronto. He is also an academic entrepreneur with three decades of expertise in drug discovery, development, and pharmaceuticals, and the co-founder and CEO of Lucid Psycheceuticals.Additional Resources:Nikean Psychedelic Psychotherapy Research Centre at UHNFirst-of-its-kind research centre will bring psychedelic psychotherapy to UHN The Revival of Psychedelic Research – ORT Times articleLucid Psycheceuticals

Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the  episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!Process chemists are the silent heroes of modern pharmaceutical sciences. They take a drug molecule coming out of medicinal chemistry research and make sense of its chemical synthesis. With tight deadlines they often must completely reinvent chemical syntheses to meet strict efficiency and cost requirements necessary to move drugs to commercial production. It's a challenging job that requires discipline and pragmatism, but a certain dose of chemical creativity at the same time.Patrick Fier, from Merck, represents the perfect profile of a great process chemist. He makes the most of the incredible resources and the culture of innovation available at Merck. His chemistry is creative and intriguing, he shows that unique mix of disruptive thinking and disciplined determination that is needed to design state-of-the-art chemical syntheses. And his talent gave him the opportunity to lead the development of Molnupiravir, the so-called COVID pill, one of the most promising antivirals used in severe Coronavirus cases.In this unique episode we have the rare opportunity to get to know a chemist who really played a key role in helping address the COVID pandemic. Keywords:  process chemistry, COVID, molnupiravir, COVID pill, pharmaceutical development, drug, antivirals, C-H functionalization, sulphonamides, phenol synthesis, medicinal chemistry, Merck Sharp & Dome

Reinforcing the supply chain of umifenovir and other antiviral drugs with retrosynthetic software, Ultrahigh-Throughput Experimentation for Information-Rich Chemical Synthesis, A map of the amine–carboxylic acid coupling system, Molecular Sonification for Molecule to Music Information Transfer Scientific Sense ® by Gill Eapen: Prof. Timothy Cernak is Assistant Professor of Medicinal Chemistry at the University of Michigan. His Lab studies the interface of chemical synthesis and computer science. Join this channel to get access to perks: https://www.youtube.com/channel/UCo2wiIHPM35xPawotek2IDA/join --- Send in a voice message: https://anchor.fm/scientificsense/message Support this podcast: https://anchor.fm/scientificsense/support

In this episode, Jonathan is joined by Dr Oliver Grundmann, Clinical Professor, Department of Medicinal Chemistry, University of Florida, Gainesville, USA. They discuss how Grundmann ended up training and teaching in the USA, their opinions on the use of vitamins, and how the gut microbiota and central nervous system are connected. Grundmann also talks about his own podcast for the University of Florida: https://addictionresearch.health.ufl.edu/.  

On this episode, I was joined by Duane Mancini, CEO and Managing Partner of Project Medtech and host of the Project Medtech Podcast. Duane and I discuss: Why he enjoys working with Startups Reimbursement considerations for Startups Importance of Regulatory Strategy for Startups Project Medtech and Medtech Money Podcasts Startup Symposiums Combination Products Startups Startup Symposium in Columbus, OH on 15-Jun-2022 - Register here Book Recommendation: Your Life Depends on It: What You can do to make better choices about your health Link ------------------------------------------------------------------------------------------------------------------------------------------------------ Duane Mancini is a chemist by training and holds a Master of Science degree in Medicinal Chemistry from the University of Toledo.  He started his medical device career at NAMSA as a technical advisor who specialized in overall biological safety planning including the use of chemical characterization to reduce the amount of biocompatibility testing needed for approval. He then moved into a senior technical advisor role at NAMSA and worked with clients on regulatory, reimbursement, and clinical strategies.  This unique and end-to-end background enabled him to be chosen to help lead NAMSA's MRO team.  In this role, he applied the NAMSA MRO approach (end to end CRO services) to medical device companies in order to accelerate time to market.  This role required working with mostly medical device start-up companies in developing and executing a get-to-market strategy. Duane then worked for Labcorp on the Medical Device and Diagnostic team as a Business Development Director bringing regulatory, reimbursement, pre-clinical and clinical support to his Medtech clients. He is currently the CEO and Managing Partner of Project Medtech.  Project Medtech is a media and advisory firm that is committed to supporting the delivery and development of innovative medical technology.

Dr. Nicholas Oberlies is the Patricia A. Sullivan Distinguished Professor of Chemistry in the Department of Chemistry and Biochemistry at the University of North Carolina at Greensboro (UNCG). Nick's lab is working to discover compounds in fungi that may be able to be used for medicines, particularly new therapeutics to treat cancer in humans. Outside of research, Nick's interests include exercising, playing soccer, and playing guitar. He also enjoys reading a wide variety of books. Nick was awarded his B.S. in Chemistry from Miami University (of Ohio) and his Ph.D. in Medicinal Chemistry and Pharmacognosy from Purdue University. Afterwards, he completed a postdoctoral fellowship at American Cyanamid. He then joined the Natural Products Laboratory at Research Triangle Institute, rising through the ranks to become Director of the Natural Products Laboratory. He joined the faculty at UNCG in 2009. Nick has received various awards and honors throughout his career including the Matt Suffness Young Investigator Award from the American Society of Pharmacognosy, the 40 Under 40 Leadership Award from the Triangle Business Journal, and the North Carolina Distinguished Speaker Award from the NC Section of the American Chemical Society. He was also recently the president of the American Society of Pharmacognosy. In our interview, he shares more about his life and science.

The Smart 7 is a daily podcast that gives you everything you need to know in 7 minutes, at 7 am, 7 days a week...With over 9 million downloads and consistently charting, including as No. 1 News Podcast on Spotify, we're a trusted source for people every day.If you're enjoying it, please follow, share, or even post a review, it all helps...Today's episode includes the following guests:Dr Gunda Georg - Regents Professor and Head of Department of Medicinal Chemistry at the University of MinnesotaAbdullah Al Noman - Graduate Research Assistant at the University of MinnesotaDick Vethaak - Marine Ecotoxicologist and professor at Deltares and Vrije Universiteit AmsterdamDr. Matthew Lazzara - Senior Scientist at the Antarctic Meteorological ResearchDr Anne Jungblut - Principal Researcher in the Life Sciences Department at the National History MuseumDr. Mubin Syed - Radiologist and Founder of RAM Medical InnovationsAnthony DiMare - CEO at BedrockGreg Beard - CEO at StrongholdIn Ireland? Why not try our Ireland Edition?Contact us over at Twitter or visit www.thesmart7.comPresented by Jamie East, written by Liam Thompson, researched by Olivia Davies and produced by Daft Doris. See acast.com/privacy for privacy and opt-out information.

The Smart 7 Ireland Edition is the daily news podcast that gives you everything you need to know in 7 minutes, at 7am, 7 days a week…Consistently appearing in Ireland's Daily News charts, we're a trusted source for people every day.If you're enjoying it, please follow, share or even post a review, it all helps…Today's episode includes references to the following guests:Dr Gunda Georg - Regents Professor and Head of Department of Medicinal Chemistry at the University of MinnesotaAbdullah Al Noman - Graduate Research Assistant at the University of MinnesotaDick Vethaak - Marine Ecotoxicologist and professor at Deltares and Vrije Universiteit AmsterdamDr. Matthew Lazzara - Senior Scientist at the Antarctic Meteorological ResearchDr Anne Jungblut - Principal Researcher in the Life Sciences Department at the National History MuseumDr. Mubin Syed - Radiologist and Founder of RAM Medical InnovationsAnthony DiMare - CEO at BedrockGreg Beard - CEO at StrongholdContact us over at Twitter or visit www.thesmart7.comPresented by Ciara Revins, written by Liam Thompson and produced by Daft Doris. See acast.com/privacy for privacy and opt-out information.

Today Josh speaks with Dr. Mark Vorderbruggen about food, health, and sustainability. Mark is a chemist, ethnobotanist, author, speaker, and foraging expert. He has a Masters in Medicinal Chemistry, a Ph.D. in physical organic chemistry from Rensselaer Polytechnic Institute.For over 18 years he worked as a research chemist in the oil industry using his knowledge of natural products to develop environmentally-friendly replacements for traditional oil field chemicals.In 2008 he started what would become one of the top foraging websites online, Foraging Texas, and has since become nationally recognized as an expert in wild edible and medicinal plants. In 2016 he released the book "Foraging", published as part of the popular Idiot's Guide series under Penguin Random House.Currently, he is the co-founder of Medicine Man Plant Co, where Mark has applied his decades of research and experience as a chemist to formulate blends of these traditional medicinal herbs and mushrooms with the most scientific backing.Some of the topics we dive into are: Dynamic ecosystems, and the co-evolution of plants with humans.The 80/20 on how to identify and forage edible plants.The prehistoric root causes for the obesity, diabetes, and chronic illness epidemic in modern times.Topsoil depletion and the micronutrients we're missing in modern diets.Our detachment from nature and its downstream effects.Forest bathing and outdoor therapy for ADHD.The benefits of juggling and throwing things.Medicinal mushrooms, cancer, and the immune system.How to grow your own Lions Mane and other medicinal mushrooms.The pharmaceutical industry and misaligned incentives.The lack of integrity in the nootropics and supplements industry.How to re-establish permaculture in your backyard.Music by Kirby Johnston – check out his band Aldaraia on Spotify