Podcasts about hydrophobic

Dean talks about the international code for roofing materials in California, low pressure issues and the steps on what to do to fix the issue. Also, information about re-roofing a home, dealing with HOA policies and shower doors with a Hydrophobic coating that doesn't require constant cleaning duties. 

Bioconjugation of antibodies to drugs via chemical linkers is how antibody drug conjugates (ADCs) are made. We're joined by Matt Giese, Senior Scientist at Vector Laboratories, who talks us through the complex chemistry options and biodesign considerations that have to be considered and balanced when making a successful ADC.How does one build the skillset to work in biodesign of ADCs you might ask? Well, Matt's career path might not provide a clearcut roadmap like you might hope. That's because Matt started his career as an auto mechanic, moved into art, went back to auto mechanics, worked as baggage handler and as a construction worker, all before ever finding chemistry. If you think that's a convoluted path, just wait to hear about his academic and professional work journeys.  You'll revel in following this journey, and in the lessons and diverse skills learned along the way. Join us to hear it yourself, from who might just be the most interesting man in chemistry!Related episodes:Season 5, Ep.7: The life-altering impact of one chemist's sabbaticalSeason 2, Ep.1: Chemistry: a modern American dreamSeason 3, Ep.5: On the COVID pill and other process chemistry tales Bonus content!Access bonus content curated by this episode's guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.View the video of this episode on www.thermofisher.com/chemistry-podcast. A free thank you gift for our listeners! Request your free Bringing Chemistry to Life t-shirt on our episode website.Use Podcast Code: LabRatsRul3 in July or OchemRcks in August. We read every email so please share your questions and feedback with us! Email helloBCTL@thermofisher.com

It's been 3 years, 2 month, and 30 days under the boot of the oppressive Dark Brandon Regime, reaching out to the lesser people in its empire like Donald Trump. Also, its the 169th episode one day before 4/20. Nice. Other Titles Farm to Bag Book of YouTube Lotta Dong Special Show Links: RealPage rent-fixing lawsuit highlights use of algorithms to set rents https://www.marketplace.org/2024/04/16/realpage-lawsuit-algorithms-rent/ Citadel Securities blasts Trump Media CEO Devin Nunes over short-selling letter https://www.cnbc.com/2024/04/19/citadel-securities-blasts-trump-media-ceo-over-djt-short-sale-letter.html Man sets himself on fire outside Manhattan courthouse where Trump faces hush money case https://www.nbcnewyork.com/news/local/man-sets-himself-fire-trump-trial-manhattan/5336882/

Giveaway week from https://whitetailcompany.com/  Contact me jon@whitetaillandscapes.com In this episode, Jon Teater (Whitetail Landscapes) discusses his upcoming Deer Habitat Master Class. Jon discusses the benefits and negatives of hinge cutting. Jon discusses the application of hinge cutting and why those that are naysayers are missing the benefits of cutting timber with different techniques. Jon discusses soils how to ensure  Jon discusses adaptive design management and solving issues like drought, what you can do from a design standpoint to reduce the impacts of low rainfall. Jon discusses plants that survive in drought and what plants we want to use in our food plots in these scenarios. Jon discusses rules surrounding soil management and how to create more water retention through earthworks. Jon discusses irrigation and watering principles that will help support plants all year long. Jon discusses windbreaks and how these features will support deer, habitat, and food plots. Jon discusses cold air dams and planting fruit trees in low lying areas. Jon explains how to evaluate microclimates and the benefit of adding water resources and ponds to key areas. Jon discusses his Master Class in New York and the benefits and related content. Jon explains how to design properties around highly pressured hunting and ways to stack mature bucks throughout your properties. Jon details having multiple mature bucks spending weeks at a time on a property in the midst of other pressured areas. Jon discusses deer population, food, and how to ensure big bucks stay on our properties more consistently. Social Links https://whitetailcompany.com/ https://myco-habitat.com/ https://whitetaillandscapes.com/ https://www.facebook.com/whitetaillandscapes/ https://www.instagram.com/whitetail_landscapes/?hl=en Learn more about your ad choices. Visit megaphone.fm/adchoices

Giveaway week from https://whitetailcompany.com/  Contact me jon@whitetaillandscapes.comIn this episode, Jon Teater (Whitetail Landscapes) discusses his upcoming Deer Habitat Master Class. Jon discusses the benefits and negatives of hinge cutting. Jon discusses the application of hinge cutting and why those that are naysayers are missing the benefits of cutting timber with different techniques.  Jon discusses soils how to ensure  Jon discusses adaptive design management and solving issues like drought, what you can do from a design standpoint to reduce the impacts of low rainfall.  Jon discusses plants that survive in drought and what plants we want to use in our food plots in these scenarios. Jon discusses rules surrounding soil management and how to create more water retention through earthworks. Jon discusses irrigation and watering principles that will help support plants all year long. Jon discusses windbreaks and how these features will support deer, habitat, and food plots. Jon discusses cold air dams and planting fruit trees in low lying areas. Jon explains how to evaluate microclimates and the benefit of adding water resources and ponds to key areas.Jon discusses his Master Class in New York and the benefits and related content. Jon explains how to design properties around highly pressured hunting and ways to stack mature bucks throughout your properties. Jon details having multiple mature bucks spending weeks at a time on a property in the midst of other pressured areas. Jon discusses deer population, food, and how to ensure big bucks stay on our properties more consistently.Social Linkshttps://whitetailcompany.com/https://myco-habitat.com/https://whitetaillandscapes.com/https://www.facebook.com/whitetaillandscapes/https://www.instagram.com/whitetail_landscapes/?hl=en

I got a question from a podcast listener today about peat - does it retain water or repel it? Here's more info!

What's new at the P&S Detail Products Booth? Enjoying the steady but not overpacked attendance of SEMA 2023. And surprise pushup contest between Justin Labato and Kevin Davis Guest: Sydni Brae Gwinn P&S Detail Products https://psdetailproducts.com/ Hosts: @JodySedrick  and Rod Puzey The RoadFS Software https://roadfs.com

In this hydrophobic episode, we talk about the brand new Pikmin game, the new Barbie and Oppenheimer movies, controversy surrounding the new Assassins Creed game, Twitter rebranding to X, CSGO skins and lucky winner of a rare skin and Microsoft's acquisition of Activision/Blizzard.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.13.548611v1?rss=1 Authors: Sansbury, S. E., Serebrenik, Y. V., Lapidot, T., Burslem, G. M., Shalem, O. Abstract: System-level understanding of proteome organization and function requires methods for direct visualization and manipulation of proteins at scale. We developed an approach enabled by high-throughput gene tagging for the generation and analysis of complex cell pools with endogenously tagged proteins. Proteins are tagged with HaloTag to enable visualization or direct perturbation. Fluorescent labeling followed by in situ sequencing and deep learning-based image analysis identifies the localization pattern of each tag, providing a birds-eye-view of cellular organization. Next, we use a hydrophobic HaloTag ligand to unfold tagged proteins, inducing spatially restricted proteotoxic stress that is read out by single cell RNA sequencing. By integrating optical and perturbation data, we map compartment-specific responses to protein misfolding, revealing inter-compartment organization and direct cross-talk, and assigning proteostasis functions to uncharacterized genes. Altogether, we present a powerful and efficient method for large-scale studies of proteome dynamics, function, and homeostasis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Safe places and safe people ask good questions that may not feel safe at all, but they have goodness flowing through them. I need a place where I can go and feel safe. So many people have opinions and are quick to share them. Lightning fast to draw a conclusion and speed of light to share it. I've seen people shrivel up and wither under the bombardment of others' opinions. Something dies within them. They become like Hydrophobic soil. That's a type of soil that actively repels water. Add a drop of water to the surface, and it runs away and isn't taken in. You get to the point that you don't share anything because you know what you get back will feel like an attack. I stress the word ‘feel' because it may not be an attack, but you have been abused so often that everything now feels like a threat. So what's a safe place? Is it a fortress where you can hide away and no one comes near? Perhaps the place behind a mask of ‘everything s fine.' Got to keep up appearances. Could it be a physical place where you know you won't be interrupted? You can hide away and ‘be yourself' whatever that might mean. Is a safe place somewhere where you won't be asked questions? Maybe it's a kind of soul place where you know others will welcome you with open, nonjudgmental arms and with a sort of gentle curiosity. How would you define a safe place? Not safe, but good When I hear the word ‘safe,' my mind often goes to the C.S. Lewis book The Lion, The Witch, and the Wardrobe. In the story, some children are on an adventure and are exploring a cursed and frozen land called Narnia. They are welcomed into the home of Mr. and Mrs. Beaver and learn about the great king Aslan and that he is a lion. One of the children asks a very fearful question about this lion. “Is he—quite safe? I shall feel rather nervous about meeting a lion.” “That you will, dearie, and no mistake,” said Mrs. Beaver. “If there's anyone who can appear before Aslan without their knees knocking, they're either braver than most or else just silly.” “Then he isn't safe?” said Lucy. “Safe?” said Mr. Beaver; “don't you hear what Mrs. Beaver tells you? Who said anything about safe? ‘Course he isn't safe. But he's good. He's the King, I tell you.' Do you want ‘safe' or do you want ‘good.'? We want safe first but in the context of goodness going forward. Is God safe? Is God good, and if so, then what is God good for? The quick and the slow place James, a early church pastor, wrote these words to the little home groups of Christians meeting together in what we would now call church. You must understand this, my beloved: let everyone be quick to listen, slow to speak, slow to anger; for your anger does not produce God's righteousness. James 1:19-20 Quick to listen, slow to speak, slow to anger. Here are some definitions Quick –taxýs (Greek) – swift, speedy, without unnecessary delay. Listen – akoúō (greek)  – properly, to hear (listen); (figuratively) to hear God's voice which prompts Him to birth faith within. Akoúō is the root of the English term “acoustics.” Slow – bradýs (greek) – as in taking time to deliberate. A sense of being unhurried. Speak – laleó (greek) – talk, chatter in classical Greek, but in New Testament, a more dignified word. I speak, say. Does your church have good acoustics?  Is it a place where there is a quickened delight in listening? No F.A.S.S. It's a discipline, a training ground, a practice to work at. It's the humility of listening well. I fail at it constantly because my brain wants to F.A.S.S. – fix, advise, save, or set straight. Using a taxi (taxýs – Greek) I quickly resolve the problem and then move on to F.A.S.S. someone else. James wants us to go slow and be unhurried in our conversation. Can I ask more questions? Gentle open-ended questions? Curious to know the acoustics of the heart of the other. To be a safe person and to offer a safe place is to slow down. Be deliberate and unhurried in your conversation. Anything outside of this may come from and generate a place of anger. Frustrations leak out into the space and stifle love. Have I listened well? Often, I will ask these questions at the end of a church conversation. What are you going to take away from our time together? What have you heard? What have you written down in your notebook that you can consider in unhurried leisure? Safe places and safe people ask good questions that may not feel safe at all  , but they have goodness flowing through them. Quotes to consider It's time we paid whatever price must be paid to become part of a spiritual community rather than an ecclesiastical organization. It's time to build the church, a community of people who take refuge in God and encourage each other to never flee to another source of help, a community of folks who know the only way to live in this world is to focus on the spiritual life – our life with God and others.  It won't be easy, but it will be worth it.  Our impact on the world is at stake. Larry Crabb The Safest Place on Earth Churches that pedal beliefs and belonging as a substitute for following the Way are offering spiritual junk food. Beliefs and belonging are certainly tasty and they may temporarily satisfy some apparent needs but they do not meet our deepest spiritual longings. David Benner No one person can fulfill all your needs. But the community can truly hold you. The community can let you experience the fact that, beyond your anguish, there are human hands that hold you and show you God's faithful love. Henri Nouwen  Sensitive listeners respond to comments with words that convey an interest in hearing more, sentences that open the door to information.  Words that open doors transmit two messages: 1. ‘I am interested in whatever you have to say.' 2.'I will accept you regardless of what you say.' Larry Crabb  It is usually most helpful to ask questions that are more about the person than about the problem. Parker J. Palmer There are questions which illuminate, and there are those that destroy. We should ask the first kind. Isaac Isador Rabi. Questions to answer What would it be like to be listened into wellness? Why do you think we are quick to speak and slow to listen? When have you been listened to at a deep level? Why was this significant? Further reading Barry Pearman Photo by Steve Johnson on Unsplash   Read this further here FOLLOW ME! Email me: barry@turningthepage.co.nz Website: https://turningthepage.co.nz/ Facebook: https://www.facebook.com/turningthepage1atatime Twitter: https://twitter.com/barrypearman Instagram: https://www.instagram.com/barry_pearman/ Podcast https://turningthepage.co.nz/podcast-listen-mental-health/ Support Turning the Page with a Donation https://turningthepage.co.nz/give/ Read this further here

Discussion about Come, Follow Me, "Be Not Afraid," Matthew 14; Mark 6; John 5-6.

Reforming my black iron oxide glitter mix, mixing paste with hands, asmr water sounds. --- Send in a voice message: https://podcasters.spotify.com/pod/show/asmrfamilia/message Support this podcast: https://podcasters.spotify.com/pod/show/asmrfamilia/support

This is prep for my black gym chalk collab series with Calico Crunch ASMR. Series starts on Monday!!

Dimitri shares how lotion works… slowly… Check out Linh's app, Not Phở, a cook that introduces the user to Vietnamese cuisine, especially dishes other than Phở. It runs on iPhone, iPad, and Mac. It also have an iMessage sticker pack so that you can share with all your friends and family. App Store: https://apps.apple.com/app/apple-store/id1525104124?pt=14724&ct=Podcast&mt=8 Website: https://notpho.app Follow us on Twitter: https://twitter.com/LinhAndDimiChan Follow Dimitri on Twitter: https://twitter.com/dimitribouniol Follow Linh on Twitter: https://twitter.com/linhbouniol Follow Linh on Instagram: https://www.instagram.com/linhbouniol

This is Chewing The Cud! Bringing you a roundup of showbiz news, things gathered from the internet and a special feature every week. With a LGBTQI+ focus and a bit of innuendo thrown in.Leigh talks about a stand in on a Marvel-lous Netflix show, while Mike shares a great way of keeping energy bills low. Then things get all Hydrophobic in That's Science That Is.All this and more! #ChewingTheCud

Tropaeolum is the Latin name for that almost weedy, but seriously colourful plant called Nasturtium Most gardeners know them, many grow them (in frost-free locations), some eat them and others find them a bit of a pain in the bottom due to their rampant growth. The famous painter Monet was a huge fan too! They hail from Central and Southern America; flower colours are bright in the red, orange and yellow spectra (plus a heap of other bred, fancy hues) and I reckon they literally brighten any garden with that blast of colours; They are easy to grow in almost any type of soil (especially the poorer soils), don't really like rich soil with lots of fertilisers and their best attribute is the ability to give a huge dash of colour in the most boring part of your garden; Tropaeolum makes you smile – you simply can't help it! Remember that frosts can kill them, but seeing they are actually annuals, their seeds will give you a brand new crop every spring. A really interesting did-you-know is that Nasturtium is an alternative host for the white cabbage butterfly caterpillar, despite the fact that Nasturtiums are not a Brassica, nor are they closely related to the cabbage family. So if you don't want white butterfly caterpillars in your cabbages, broccoli, caulis and sprouts, don't grow Nasturtium near your cabbage patch! You can eat the leaves, the seeds and the flowers – taste is described as “peppery” or resembling “honey-mustard” The flowers can be eaten or used in fancy cookery recipes, stuffed with cream cheese or topped on vinaigrette-laced salad, but remember that the flowers tend to wilt quite quickly, so chuck them on that salad at the last moment before serving. Even washing the flowers makes them “flaccid”, so keep them au naturel and consume them raw… without washing! And that last bit of info might sound weird, but makes perfect scientific sense. If you look at the plant after a shower of rain, you'll find that the leaves actually hold the raindrops on the surface in perfect little bubbles of “quick-silver”. We have a scientific term for that: the leaf surface is Hydrophobic; it repels water. There are a few plants that show this hydrophobic feature: Lotus, some types of water lilies, and indeed: cabbages! If you look further into the natural world you may find that the wings of flies (crane flies!) and heaps of other insects have a similar repellency of water droplets. For nasturtium and Lotus, etc, this repellency is caused by a nano-structure on the leaf surface. It literally forces the droplets of water to become slippery objects on the leaf that removes dirt from the surface and tosses it all off the leaves when the droplets become too large. In other words: due to those nano-structures, those leaves become self-cleaning surfaces! All you need is a bit of water to clean it on a regular basis. Now, wouldn't it be a clever idea to – somehow – put that nano structure on the glass of your shower door? Guess what: that system exists already. Not just on glass but also on floor tiles, roof tiles, on concrete and on paint. Biomimicry! It's how we learn from Nature and design according to ancient natural processes!See omnystudio.com/listener for privacy information.

Hydrophobic sand is a type of sand that's been coated so that it stays completely dry when you dip it in water and take it out. Hydrophobic sand has had some utility use, but it's probably best known as a toy. Listen to your hosts Rachel Teichman, LMSW and Victor Varnado, KSN as they take a deep dive into hydrophobic sand. Produced and hosted by Victor Varnado & Rachel Teichman Full Wikipedia article here:https://en.wikipedia.org/wiki/Hydrophobic_sand WE APPRECIATE YOUR SUPPORT ON PATREON!https://www.patreon.com/wikilistenpodcast Find us on social media! https://www.facebook.com/WikiListen Instagram @WikiListen Twitter @Wiki_Listen Get bonus content on Patreon Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Concrete Logic podcast, we brought on Brent Rollins and Scott DiLoreto from Spray-Lock to discuss colloidal silica. If you are like most folks, you probably never heard of colloidal silica (CS). It is a product that can be sprayed on concrete during concrete placement or long after the concrete is cured. It can even be used as an additive to ready-mix concrete. Once CS is applied to the concrete, it penetrates and fills up the microscopic (nano) voids it finds in the concrete and essentially makes the concrete waterproof! Although CS keeps water from penetrating the concrete, it still allows water in the concrete mix to escape just like it normally would in the curing process. After this interview with Brent and Scott, your head will start spinning on how you can use colloidal silica in your future projects. Episode References Guest: Brent Rollins, VP of Business Development, abrollins@spraylock.com Guest: Scott DiLoreto, Director of Sales, sdiloreto@spraylock.com Spray-Lock website: https://www.concreteprotection.com/ Podcast host: Seth Tandett, seth@concretelogicpodcast.com Podcast website: concretelogicpodcast.com

What are Van der Waals forces? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O'Reilly explore the fascinating world of surfaces, biomimicry, and Formula 1 with physicist and author of Sticky: The Science of Surfaces, Laurie Winkless. NOTE: StarTalk+ Patrons can watch or listen to this entire episode commercial-free here: https://www.startalkradio.net/show/sticky-science-the-force-be-with-you-with-laurie-winkless/Thanks to our Patrons Artist formerly known as James Smith, Joseph Strasser, Salvatore Scuiri, Kyle Dagg, Luke Ehlers, Paul Bowe, Jason R.Y. Rankin, Ann Young, Jasam Mohammed, and Jan Bojarp for supporting us this week.Photo Credit: Peter Heeling, CC0, via Wikimedia Commons

What are Van der Waals forces? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O'Reilly explore the fascinating world of surfaces, biomimicry, and Formula 1 with physicist and author of Sticky: The Science of Surfaces, Laurie Winkless.NOTE: StarTalk+ Patrons can watch or listen to this entire episode commercial-free.Thanks to our Patrons Artist formerly known as James Smith, Joseph Strasser, Salvatore Scuiri, Kyle Dagg, Luke Ehlers, Paul Bowe, Jason R.Y. Rankin, Ann Young, Jasam Mohammed, and Jan Bojarp for supporting us this week.Photo Credit: Peter Heeling, CC0, via Wikimedia Commons 

You will hear the following terms used during the interview. I've included some descriptions here. Chirality – Chirality is a feature where an object can be distinguished from a mirror-image version of itself (for instance left and right gloves, or shoes). In chemistry, chirality is often due to the presence of an asymmetrical carbon atom. Chiral isomers are identified as either L-type or D-type, based on how polarized light is rotated when passing through a molecule.Superstructure – In the context of this discussion “When the structures become way, way bigger than the building blocks, you can call the superstructures.” They represent massive polymers of the base construction moleculesNanomaterials / Nanoparticles – A term used to describe substances where the base unit is small – between 1 nm - 100 nm along one or more dimensionsAmyloid beta-peptide (also known as Abeta, or Aβ) – Peptides between 36-43 amino acids long that form insoluble amyloid plaques in the brains of people suffering from Alzheimer's disease. Although the specific role of Amyloid plaques in Alzheimer's disease is not fully understood, it is widely accepted that they are responsible for the pathology of the disease.Peptide – A short chain of 2-50 amino acids, linked by a peptide bond. A dipeptide has two amino acids in the chain, a tripeptide has three amino acids, and so on.Hydrophobic pockets – When folded into a functional configuration, the amino acids of a protein can be brought into physical proximity. When the majority of amino acids surrounding an ‘opening' in the surface of the protein are hydrophobic, it creates a region that is unattractive to hydrophilic molecules. As the majority of biological systems are water-based, this hydrophobic region stimulates other hydrophobic regions of suitable molecules to bind. This then typically leads to downstream activation or effectCatalytic triads - a set of three coordinated amino acids that can be found in the active site of some enzymes. Catalytic triads are most commonly found in hydrolase and transferase enzymes.Antimicrobial resistance – This is an evolutionary process where bacteria become immune to the effects of antimicrobial agents (such as antibiotics). Typically this is caused by exposure are designed to kill bacteria. To do this, the bacteria need to be exposed to the agents at sub-lethal levels. As antimicrobial agents accumulate in the environment, it is believed that this provides an opportunity for bacteria to be exposed at sub-lethal levels, which accelerates the rate at which the bacteria develops resistance to the antimicrobial.We discussed the drawing of Alice going through the looking glass during our discussion, you can see it at https://www.sciencephoto.com/media/995913/view/through-the-looking-glass-alice-pushes-through-the-mirror.Silvia also mentions an article in the journal ACS Nano, you can find that at: https://pubs.acs.org/doi/10.1021/acsnano.0c09386#Silvia is contactable on social media, you can find her on LinkedIn https://www.linkedin.com/in/silvia-marchesan-2590712/On Twitter, search @MarchesanLabThe group website is www.marchesanlab.com Our theme music is "Wholesome" by Kevin MacLeod (https://incompetech.com)Music from https://filmmusic.ioLicense: CC BY (http://creativecommons.org/licenses/by/4.0/) Connect with me (Paul) at https://www.linkedin.com/in/paulorange/H.E.L. group can be found at www.helgroup.com online,on LinkedIn at https://www.linkedin.com/company/hel-group/ on Twitter we're @hel_group, https://twitter.com/hel_groupor search for us on Facebook 

This episode is also available as a blog post: http://biopatrika.com/2021/03/11/interview-safe-nanomedicine-deliver-hydrophobic-cancer-drug/

In this episode you’ll hear about ways to prepare the chard, kale or other greens you froze last summer. Learn why water beads up on some leaves, all about Cannas, and if hydrogen peroxide is a good thing to use on plant problems. :30  What’s for dinner: Greens from the freezer 4:22 Insider Information: What are “Hydrophobic leaves?” 8:55 Eat/Drink/Grow:  Cannas        17:42 Love Letters and Questions:  Samantha asked about using hydrogen peroxide in the garden

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. WISHING EVERYONE A VERY MERRY CHRISTMAS!! To start episode, I will be emphasizing the essence of this great holiday and festive season Bonding fosters complete, proper interaction of drugs with receptors. The most important and major bonds to be known are Covalent, Electrostatic and Hydrophobic. Strongest bonds are covalent, many a times irreversible in nature. This concept will be clear with good examples. Next I will be talking about Electrostatic bonds, Their strength may vary from very strong to weak to very weak, Last to discuss will be hydrophobic bonds. A relation of drug selectivity will be stated along with bonding. Next I will cover a word about inert substances or drugs. Drug shape along with characteristics of "Chirality" or "Stereoisomerism".All the concepts will be crystal clear with apt examples. A fact about current overpowered use of racaemic mixture of drugs will be discussed along with the basis to justify the rationality of this point of talk. Then lastly, I will talk about Rational Drug designing, in very brief though its quite important topic of conversation, I will be talking about most important points and the importance of rational drug designing.With a promise to continue such informative crispy conversations without any delay, no ideas to hamper your holiday, Christmas eve plans, with a little sneak peak about next episode, time to wave y'all HAPPY CHRISTMAS again!! GOD BLESS ALL !! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.WISHING EVERYONE A VERY MERRY CHRISTMAS!! To start episode, I will be emphasizing the essence of this great holiday and festive seasonBonding fosters complete, proper interaction of drugs with receptors. The most important and major bonds to be known are Covalent, Electrostatic and Hydrophobic. Strongest bonds are covalent, many a times irreversible in nature. This concept will be clear with  good examples.Next I will be talking about Electrostatic bonds, Their strength may vary from very strong to weak to very weak, Last to discuss will be hydrophobic bonds. A relation of drug selectivity will be stated along with bonding. Next I will cover a word about inert substances or drugs.Drug shape along with characteristics of "Chirality" or "Stereoisomerism".All the concepts will be crystal clear with apt examples. A fact about current overpowered use of racaemic mixture of drugs will be discussed along with the basis to justify the rationality of this point of talk.Then lastly, I will talk about Rational Drug designing, in very brief though its quite important topic of conversation, I will be talking about most important points and the importance of rational drug designing.With a promise to continue such informative crispy conversations without any delay, no ideas to hamper your holiday, Christmas eve plans, with a little sneak peak about next episode, time to wave y'all HAPPY CHRISTMAS again!! GOD BLESS ALL !! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. WISHING EVERYONE A VERY MERRY CHRISTMAS!! To start episode, I will be emphasizing the essence of this great holiday and festive season Bonding fosters complete, proper interaction of drugs with receptors. The most important and major bonds to be known are Covalent, Electrostatic and Hydrophobic. Strongest bonds are covalent, many a times irreversible in nature. This concept will be clear with good examples. Next I will be talking about Electrostatic bonds, Their strength may vary from very strong to weak to very weak, Last to discuss will be hydrophobic bonds. A relation of drug selectivity will be stated along with bonding. Next I will cover a word about inert substances or drugs. Drug shape along with characteristics of "Chirality" or "Stereoisomerism".All the concepts will be crystal clear with apt examples. A fact about current overpowered use of racaemic mixture of drugs will be discussed along with the basis to justify the rationality of this point of talk. Then lastly, I will talk about Rational Drug designing, in very brief though its quite important topic of conversation, I will be talking about most important points and the importance of rational drug designing.With a promise to continue such informative crispy conversations without any delay, no ideas to hamper your holiday, Christmas eve plans, with a little sneak peak about next episode, time to wave y'all HAPPY CHRISTMAS again!! GOD BLESS ALL !! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

字数限制，只能展示如下化学（材料）：Triple-halide wide-band gap perovskites with suppressed phase segregation for efficient tandems 三卤化物宽带隙钙钛矿可抑制光诱发的相分离从而达致高效率的叠层光伏电池A droplet-based electricity generator with high instantaneous power density 一种基于液滴的高功率密度发电机Balancing volumetric and gravimetric uptake in highly porous materials for clean energy权衡多孔材料的体积和重量吸附率以获取清洁能源Ultrafast control of vortex microlasers涡旋微激光器的超快控制Hydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol甲烷氧化制甲醇过程中原位生成过氧化物的疏水沸石改性Transparent ferroelectric crystals with ultrahigh piezoelectricity具有超高压电效应的透明铁电晶体Wafer-scale single-crystal hexagonal boron nitride monolayers on Cu (111)Cu (111)上的 wafer 规模的单晶六方氮化硼单层Mott and generalized Wigner crystal states in WSe2/WS2 moire superlatticesWSe2/WS2云纹超晶格中的 Mott 和广义 Wigner 晶体态Fully hardware-implemented memristor convolutional neural network完全硬件实现的记忆电阻卷积神经网络Asynchronous carbon sink saturation in African and Amazonian tropical forests非洲和亚马逊热带森林碳汇饱和度异步Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc脂质纳米盘中 M2毒蕈碱受体 -β- 抑制素复合物的结构Design of robust superhydrophobic surfaces坚固的超疏水表面的设计General synthesis of two-dimensional van der Waals heterostructure arrays二维 van der Waals 异质结构阵列的一般合成Accelerated discovery of CO2 electrocatalysts using active machine learning使用主动机器学习加速发现二氧化碳电催化剂Observation of hydrogen trapping at dislocations, grain boundaries, and precipitates在位错，晶界和沉淀处观察氢捕获Seeking new, highly effective thermoelectrics寻找新的高效热电偶Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice二维六角冰的边缘结构和生长的原子成像Li metal deposition and stripping in a solid-state battery via Coble creep利用 Coble 蠕变技术在固态电池中沉积和剥离 Li 金属Single-particle spectroscopy for functional nanomaterials功能性纳米材料的单粒子光谱学Strain-hardening and suppression of shear-banding in rejuvenated bulk metallic glass再生大块金属玻璃的应变硬化及剪切带抑制天文物理Quantum anomalous Hall effect in intrinsic magnetic topological insulator MnBi2Te4内禀磁性拓扑绝缘体 MnBi2Te4中的量子反常霍尔效应Tunable correlated Chern insulator and ferromagnetism in a moire superlattice莫瓦超晶格中的可调相干陈氏绝缘体及铁磁性A single photonic cavity with two independent physical synthetic dimensions具有两个独立物理合成尺寸的单光子腔Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor铁基超导体涡旋零模的近量子化电导平台One-dimensional van der Waals heterostructures一维 van der Waals 异质结构The water lily genome and the early evolution of flowering plants睡莲基因组与被子植物的早期进化Conversion of non-van der Waals solids to 2D transition-metal chalcogenides非 van der Waals 固体向二维过渡金属硫族化合物的转化Assessing progress towards sustainable development over space and time评估跨越时空实现可持续发展的进展情况Localization and delocalization of light in photonic moire lattices光子莫尔晶格中光的定位和离域Entanglement of two quantum memories via fibres over dozens of kilometres通过几十公里长的光纤纠缠两个量子存储器A planet within the debris disk around the pre-main-sequence star AU Microscopii在主序前星 AU Microscopii 周围的碎片盘内的行星Aligned, high-density semiconducting carbon nanotube arrays for high-performance electronics用于高性能电子学的定向高密度半导体碳纳米管阵列Entanglement-based secure quantum cryptography over 1,120 kilometres基于纠缠的安全量子密码学超过1120公里Photocurrent detection of the orbital angular momentum of lightPhotocurrent 检测光的轨道角量子数Quantum entanglement between an atom and a molecule原子与分子之间的量子纠生理学或医学Pan-cancer analysis of whole genomes全基因组泛癌分析生理学或医学Analyses of non-coding somatic drivers in 2,658 cancer whole genomes2,658个癌症全基因组中非编码体细胞驱动因子的分析生理学或医学Genomic basis for RNA alterations in cancer癌症 RNA 改变的基因组学基础生理学或医学Single-Cell Transcriptome Atlas of Murine Endothelial Cells鼠内皮细胞的单细胞转录组图谱生理学或医学Gasdermin E suppresses tumour growth by activating anti-tumour immunityGasdermin e 通过激活抗肿瘤免疫抑制肿瘤生长生理学或医学N-6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription染色体相关调控 RNA 的 n-6- 甲基腺苷调控染色质状态和转录生理学或医学Construction of a human cell landscape at single-cell level构建单细胞水平的人类细胞景观生理学或医学The genetic architecture of the human cerebral cortex人类大脑皮层的遗传结构生理学或医学Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis过氧化氢传感器 HPCA1是拟南芥(Arabidopsis)中的 LRR 受体激酶生理学或医学Microglia mediate forgetting via complement-dependent synaptic elimination小胶质细胞通过补体依赖性突触消除介导遗忘生理学或医学Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense肠支配伤害感受神经元调节 Peyer's Patch Microfold 细胞和 SFB 水平介导沙门氏菌宿主防御生理学或医学A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1由 RIPK1的不可切割变体引起的显性自身炎症性疾病生理学或医学

字数限制，只能展示如下化学（材料）：Triple-halide wide-band gap perovskites with suppressed phase segregation for efficient tandems 三卤化物宽带隙钙钛矿可抑制光诱发的相分离从而达致高效率的叠层光伏电池A droplet-based electricity generator with high instantaneous power density 一种基于液滴的高功率密度发电机Balancing volumetric and gravimetric uptake in highly porous materials for clean energy权衡多孔材料的体积和重量吸附率以获取清洁能源Ultrafast control of vortex microlasers涡旋微激光器的超快控制Hydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol甲烷氧化制甲醇过程中原位生成过氧化物的疏水沸石改性Transparent ferroelectric crystals with ultrahigh piezoelectricity具有超高压电效应的透明铁电晶体Wafer-scale single-crystal hexagonal boron nitride monolayers on Cu (111)Cu (111)上的 wafer 规模的单晶六方氮化硼单层Mott and generalized Wigner crystal states in WSe2/WS2 moire superlatticesWSe2/WS2云纹超晶格中的 Mott 和广义 Wigner 晶体态Fully hardware-implemented memristor convolutional neural network完全硬件实现的记忆电阻卷积神经网络Asynchronous carbon sink saturation in African and Amazonian tropical forests非洲和亚马逊热带森林碳汇饱和度异步Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc脂质纳米盘中 M2毒蕈碱受体 -β- 抑制素复合物的结构Design of robust superhydrophobic surfaces坚固的超疏水表面的设计General synthesis of two-dimensional van der Waals heterostructure arrays二维 van der Waals 异质结构阵列的一般合成Accelerated discovery of CO2 electrocatalysts using active machine learning使用主动机器学习加速发现二氧化碳电催化剂Observation of hydrogen trapping at dislocations, grain boundaries, and precipitates在位错，晶界和沉淀处观察氢捕获Seeking new, highly effective thermoelectrics寻找新的高效热电偶Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice二维六角冰的边缘结构和生长的原子成像Li metal deposition and stripping in a solid-state battery via Coble creep利用 Coble 蠕变技术在固态电池中沉积和剥离 Li 金属Single-particle spectroscopy for functional nanomaterials功能性纳米材料的单粒子光谱学Strain-hardening and suppression of shear-banding in rejuvenated bulk metallic glass再生大块金属玻璃的应变硬化及剪切带抑制天文物理Quantum anomalous Hall effect in intrinsic magnetic topological insulator MnBi2Te4内禀磁性拓扑绝缘体 MnBi2Te4中的量子反常霍尔效应Tunable correlated Chern insulator and ferromagnetism in a moire superlattice莫瓦超晶格中的可调相干陈氏绝缘体及铁磁性A single photonic cavity with two independent physical synthetic dimensions具有两个独立物理合成尺寸的单光子腔Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor铁基超导体涡旋零模的近量子化电导平台One-dimensional van der Waals heterostructures一维 van der Waals 异质结构The water lily genome and the early evolution of flowering plants睡莲基因组与被子植物的早期进化Conversion of non-van der Waals solids to 2D transition-metal chalcogenides非 van der Waals 固体向二维过渡金属硫族化合物的转化Assessing progress towards sustainable development over space and time评估跨越时空实现可持续发展的进展情况Localization and delocalization of light in photonic moire lattices光子莫尔晶格中光的定位和离域Entanglement of two quantum memories via fibres over dozens of kilometres通过几十公里长的光纤纠缠两个量子存储器A planet within the debris disk around the pre-main-sequence star AU Microscopii在主序前星 AU Microscopii 周围的碎片盘内的行星Aligned, high-density semiconducting carbon nanotube arrays for high-performance electronics用于高性能电子学的定向高密度半导体碳纳米管阵列Entanglement-based secure quantum cryptography over 1,120 kilometres基于纠缠的安全量子密码学超过1120公里Photocurrent detection of the orbital angular momentum of lightPhotocurrent 检测光的轨道角量子数Quantum entanglement between an atom and a molecule原子与分子之间的量子纠生理学或医学Pan-cancer analysis of whole genomes全基因组泛癌分析生理学或医学Analyses of non-coding somatic drivers in 2,658 cancer whole genomes2,658个癌症全基因组中非编码体细胞驱动因子的分析生理学或医学Genomic basis for RNA alterations in cancer癌症 RNA 改变的基因组学基础生理学或医学Single-Cell Transcriptome Atlas of Murine Endothelial Cells鼠内皮细胞的单细胞转录组图谱生理学或医学Gasdermin E suppresses tumour growth by activating anti-tumour immunityGasdermin e 通过激活抗肿瘤免疫抑制肿瘤生长生理学或医学N-6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription染色体相关调控 RNA 的 n-6- 甲基腺苷调控染色质状态和转录生理学或医学Construction of a human cell landscape at single-cell level构建单细胞水平的人类细胞景观生理学或医学The genetic architecture of the human cerebral cortex人类大脑皮层的遗传结构生理学或医学Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis过氧化氢传感器 HPCA1是拟南芥(Arabidopsis)中的 LRR 受体激酶生理学或医学Microglia mediate forgetting via complement-dependent synaptic elimination小胶质细胞通过补体依赖性突触消除介导遗忘生理学或医学Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense肠支配伤害感受神经元调节 Peyer's Patch Microfold 细胞和 SFB 水平介导沙门氏菌宿主防御生理学或医学A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1由 RIPK1的不可切割变体引起的显性自身炎症性疾病生理学或医学

字数限制，只能展示如下化学（材料）：Triple-halide wide-band gap perovskites with suppressed phase segregation for efficient tandems 三卤化物宽带隙钙钛矿可抑制光诱发的相分离从而达致高效率的叠层光伏电池A droplet-based electricity generator with high instantaneous power density 一种基于液滴的高功率密度发电机Balancing volumetric and gravimetric uptake in highly porous materials for clean energy权衡多孔材料的体积和重量吸附率以获取清洁能源Ultrafast control of vortex microlasers涡旋微激光器的超快控制Hydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol甲烷氧化制甲醇过程中原位生成过氧化物的疏水沸石改性Transparent ferroelectric crystals with ultrahigh piezoelectricity具有超高压电效应的透明铁电晶体Wafer-scale single-crystal hexagonal boron nitride monolayers on Cu (111)Cu (111)上的 wafer 规模的单晶六方氮化硼单层Mott and generalized Wigner crystal states in WSe2/WS2 moire superlatticesWSe2/WS2云纹超晶格中的 Mott 和广义 Wigner 晶体态Fully hardware-implemented memristor convolutional neural network完全硬件实现的记忆电阻卷积神经网络Asynchronous carbon sink saturation in African and Amazonian tropical forests非洲和亚马逊热带森林碳汇饱和度异步Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc脂质纳米盘中 M2毒蕈碱受体 -β- 抑制素复合物的结构Design of robust superhydrophobic surfaces坚固的超疏水表面的设计General synthesis of two-dimensional van der Waals heterostructure arrays二维 van der Waals 异质结构阵列的一般合成Accelerated discovery of CO2 electrocatalysts using active machine learning使用主动机器学习加速发现二氧化碳电催化剂Observation of hydrogen trapping at dislocations, grain boundaries, and precipitates在位错，晶界和沉淀处观察氢捕获Seeking new, highly effective thermoelectrics寻找新的高效热电偶Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice二维六角冰的边缘结构和生长的原子成像Li metal deposition and stripping in a solid-state battery via Coble creep利用 Coble 蠕变技术在固态电池中沉积和剥离 Li 金属Single-particle spectroscopy for functional nanomaterials功能性纳米材料的单粒子光谱学Strain-hardening and suppression of shear-banding in rejuvenated bulk metallic glass再生大块金属玻璃的应变硬化及剪切带抑制天文物理Quantum anomalous Hall effect in intrinsic magnetic topological insulator MnBi2Te4内禀磁性拓扑绝缘体 MnBi2Te4中的量子反常霍尔效应Tunable correlated Chern insulator and ferromagnetism in a moire superlattice莫瓦超晶格中的可调相干陈氏绝缘体及铁磁性A single photonic cavity with two independent physical synthetic dimensions具有两个独立物理合成尺寸的单光子腔Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor铁基超导体涡旋零模的近量子化电导平台One-dimensional van der Waals heterostructures一维 van der Waals 异质结构The water lily genome and the early evolution of flowering plants睡莲基因组与被子植物的早期进化Conversion of non-van der Waals solids to 2D transition-metal chalcogenides非 van der Waals 固体向二维过渡金属硫族化合物的转化Assessing progress towards sustainable development over space and time评估跨越时空实现可持续发展的进展情况Localization and delocalization of light in photonic moire lattices光子莫尔晶格中光的定位和离域Entanglement of two quantum memories via fibres over dozens of kilometres通过几十公里长的光纤纠缠两个量子存储器A planet within the debris disk around the pre-main-sequence star AU Microscopii在主序前星 AU Microscopii 周围的碎片盘内的行星Aligned, high-density semiconducting carbon nanotube arrays for high-performance electronics用于高性能电子学的定向高密度半导体碳纳米管阵列Entanglement-based secure quantum cryptography over 1,120 kilometres基于纠缠的安全量子密码学超过1120公里Photocurrent detection of the orbital angular momentum of lightPhotocurrent 检测光的轨道角量子数Quantum entanglement between an atom and a molecule原子与分子之间的量子纠生理学或医学Pan-cancer analysis of whole genomes全基因组泛癌分析生理学或医学Analyses of non-coding somatic drivers in 2,658 cancer whole genomes2,658个癌症全基因组中非编码体细胞驱动因子的分析生理学或医学Genomic basis for RNA alterations in cancer癌症 RNA 改变的基因组学基础生理学或医学Single-Cell Transcriptome Atlas of Murine Endothelial Cells鼠内皮细胞的单细胞转录组图谱生理学或医学Gasdermin E suppresses tumour growth by activating anti-tumour immunityGasdermin e 通过激活抗肿瘤免疫抑制肿瘤生长生理学或医学N-6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription染色体相关调控 RNA 的 n-6- 甲基腺苷调控染色质状态和转录生理学或医学Construction of a human cell landscape at single-cell level构建单细胞水平的人类细胞景观生理学或医学The genetic architecture of the human cerebral cortex人类大脑皮层的遗传结构生理学或医学Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis过氧化氢传感器 HPCA1是拟南芥(Arabidopsis)中的 LRR 受体激酶生理学或医学Microglia mediate forgetting via complement-dependent synaptic elimination小胶质细胞通过补体依赖性突触消除介导遗忘生理学或医学Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense肠支配伤害感受神经元调节 Peyer's Patch Microfold 细胞和 SFB 水平介导沙门氏菌宿主防御生理学或医学A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1由 RIPK1的不可切割变体引起的显性自身炎症性疾病生理学或医学

字数限制，只能展示如下化学（材料）：Triple-halide wide-band gap perovskites with suppressed phase segregation for efficient tandems 三卤化物宽带隙钙钛矿可抑制光诱发的相分离从而达致高效率的叠层光伏电池A droplet-based electricity generator with high instantaneous power density 一种基于液滴的高功率密度发电机Balancing volumetric and gravimetric uptake in highly porous materials for clean energy权衡多孔材料的体积和重量吸附率以获取清洁能源Ultrafast control of vortex microlasers涡旋微激光器的超快控制Hydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol甲烷氧化制甲醇过程中原位生成过氧化物的疏水沸石改性Transparent ferroelectric crystals with ultrahigh piezoelectricity具有超高压电效应的透明铁电晶体Wafer-scale single-crystal hexagonal boron nitride monolayers on Cu (111)Cu (111)上的 wafer 规模的单晶六方氮化硼单层Mott and generalized Wigner crystal states in WSe2/WS2 moire superlatticesWSe2/WS2云纹超晶格中的 Mott 和广义 Wigner 晶体态Fully hardware-implemented memristor convolutional neural network完全硬件实现的记忆电阻卷积神经网络Asynchronous carbon sink saturation in African and Amazonian tropical forests非洲和亚马逊热带森林碳汇饱和度异步Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc脂质纳米盘中 M2毒蕈碱受体 -β- 抑制素复合物的结构Design of robust superhydrophobic surfaces坚固的超疏水表面的设计General synthesis of two-dimensional van der Waals heterostructure arrays二维 van der Waals 异质结构阵列的一般合成Accelerated discovery of CO2 electrocatalysts using active machine learning使用主动机器学习加速发现二氧化碳电催化剂Observation of hydrogen trapping at dislocations, grain boundaries, and precipitates在位错，晶界和沉淀处观察氢捕获Seeking new, highly effective thermoelectrics寻找新的高效热电偶Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice二维六角冰的边缘结构和生长的原子成像Li metal deposition and stripping in a solid-state battery via Coble creep利用 Coble 蠕变技术在固态电池中沉积和剥离 Li 金属Single-particle spectroscopy for functional nanomaterials功能性纳米材料的单粒子光谱学Strain-hardening and suppression of shear-banding in rejuvenated bulk metallic glass再生大块金属玻璃的应变硬化及剪切带抑制天文物理Quantum anomalous Hall effect in intrinsic magnetic topological insulator MnBi2Te4内禀磁性拓扑绝缘体 MnBi2Te4中的量子反常霍尔效应Tunable correlated Chern insulator and ferromagnetism in a moire superlattice莫瓦超晶格中的可调相干陈氏绝缘体及铁磁性A single photonic cavity with two independent physical synthetic dimensions具有两个独立物理合成尺寸的单光子腔Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor铁基超导体涡旋零模的近量子化电导平台One-dimensional van der Waals heterostructures一维 van der Waals 异质结构The water lily genome and the early evolution of flowering plants睡莲基因组与被子植物的早期进化Conversion of non-van der Waals solids to 2D transition-metal chalcogenides非 van der Waals 固体向二维过渡金属硫族化合物的转化Assessing progress towards sustainable development over space and time评估跨越时空实现可持续发展的进展情况Localization and delocalization of light in photonic moire lattices光子莫尔晶格中光的定位和离域Entanglement of two quantum memories via fibres over dozens of kilometres通过几十公里长的光纤纠缠两个量子存储器A planet within the debris disk around the pre-main-sequence star AU Microscopii在主序前星 AU Microscopii 周围的碎片盘内的行星Aligned, high-density semiconducting carbon nanotube arrays for high-performance electronics用于高性能电子学的定向高密度半导体碳纳米管阵列Entanglement-based secure quantum cryptography over 1,120 kilometres基于纠缠的安全量子密码学超过1120公里Photocurrent detection of the orbital angular momentum of lightPhotocurrent 检测光的轨道角量子数Quantum entanglement between an atom and a molecule原子与分子之间的量子纠生理学或医学Pan-cancer analysis of whole genomes全基因组泛癌分析生理学或医学Analyses of non-coding somatic drivers in 2,658 cancer whole genomes2,658个癌症全基因组中非编码体细胞驱动因子的分析生理学或医学Genomic basis for RNA alterations in cancer癌症 RNA 改变的基因组学基础生理学或医学Single-Cell Transcriptome Atlas of Murine Endothelial Cells鼠内皮细胞的单细胞转录组图谱生理学或医学Gasdermin E suppresses tumour growth by activating anti-tumour immunityGasdermin e 通过激活抗肿瘤免疫抑制肿瘤生长生理学或医学N-6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription染色体相关调控 RNA 的 n-6- 甲基腺苷调控染色质状态和转录生理学或医学Construction of a human cell landscape at single-cell level构建单细胞水平的人类细胞景观生理学或医学The genetic architecture of the human cerebral cortex人类大脑皮层的遗传结构生理学或医学Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis过氧化氢传感器 HPCA1是拟南芥(Arabidopsis)中的 LRR 受体激酶生理学或医学Microglia mediate forgetting via complement-dependent synaptic elimination小胶质细胞通过补体依赖性突触消除介导遗忘生理学或医学Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense肠支配伤害感受神经元调节 Peyer's Patch Microfold 细胞和 SFB 水平介导沙门氏菌宿主防御生理学或医学A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1由 RIPK1的不可切割变体引起的显性自身炎症性疾病生理学或医学

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.19.390179v1?rss=1 Authors: Pohorille, A., Wei, C. Abstract: To understand the transition from inanimate matter to life, we studied a process that directly couples simple metabolism to evolution via natural selection, demonstrated experimentally by Adamala and Szostak (Nat. Chem. 2013, 5, 495-501). In this process, dipeptides synthesized inside precursors of cells promote absorption of fatty acid micelles to vesicles inducing their preferential growth and division at the expense of other vesicles. The process is explained on the basis of coarse-grained molecular dynamics simulations, each extending for tens of microseconds, carried out to model fusion between a micelle and a membrane, both made of fatty acids in the absence and presence of hydrophobic dipeptides. In all systems with dipeptides, but not in their absence, fusion events were observed. They involve the formation of a stalk made by hydrophobic chains from the micelle and the membrane, similar to that postulated for vesicle-vesicle fusion. The emergence of a stalk is facilitated by transient clusters of dipeptides, side chains of which formed hydrophobic patches at the membrane surface. Committor probability calculations indicate that the size of a patch is a suitable reaction coordinate and allow for identifying the transition state for fusion. Free energy barrier to fusion is greatly reduced in the presence of dipeptides to only 4-5 kcal/mol, depending of the hydrophobicity of side chains. The mechanism of mediated fusion, which is expected to apply to other small peptides and hydrophobic molecules, provides a robust means by which a nascent metabolism can confer evolutionary advantage to precursors of cells. Copy rights belong to original authors. Visit the link for more info

On this ID the Future, biochemist Michael Denton delves further into his revelatory new book The Miracle of the Cell. Here he discusses finely tuned chemical bonds. Cellular life would be impossible if strong bonds weren’t just so for some cellular functions, and if weak bonds weren’t just so for others. Each type of bond exists in a Goldilocks zone, neither too strong nor too weak for its purposes. They’re tailored to fit. Denton also explores the miracle enzyme known as ATP synthase and some of the fine-tuning particulars of this life-essential molecular complex. Source

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.11.334979v1?rss=1 Authors: Mondal, A., Dolui, S., Dhabal, S., Bhattacharjee, A., Maiti, N. C. Abstract: Parkinson disease (PD) is linked to alpha-synuclein (aS) aggregation and deposition of amyloid in the substantia nigra region of the brain tissues. Recent reports suggested that oligomeric assembly structure could be neurotoxic to neuronal cells. In the current investigation we produced two distinct classes of aS oligomers and link the protein conformation state and stability to neuronal cell toxicity. Natural oligomers (NO) enriched with alpha-helical folds are produced in storage of aS at below -20{degrees}C for 7 days. Induced oligomer (IO), often observed in the aggregation pathway of aS were made incubating the protein solution at 37 {degrees}C. Natural oligomers remained stable and did not transform into beta-sheet rich amyloid fiber and exhibited higher toxicity (80% cell death) compared to induced oligomers. Natural oligomers were ovular shape and the size ranged between 4-5.5 nm. It maintained significant number (~ 60%) of residues in alpha-helical conformational space. However, initiation of hydrophobic zipping with beta sheet conformation was evidenced in induced oligomer (IO) and a lesser number residues (45%) remained with preference to alpha-helical secondary structure. Hydrophobic collapse leads the transformation of IO into thermodynamically most stable beta-sheet rich amyloid fibril. Molten globule like secondary structure stabilized by H-bonding in natural oligomers caused enhanced stability and cellular toxicity compared to induced oligomer. Thus off-pathway/natural oligomers could be plausible reason of neuronal cell death and possible cause of Parkinson disease. Copy rights belong to original authors. Visit the link for more info

Greek Mythology, 90s classic family films, comic books, and wizards come together to teach you about hydrophobic coatings! This coating technology touches nearly everyone because their main function...protecting touchscreen displays from finger prints!

HydrophobicThe Polarization of our SocietyTom Donnan pt 1 (https://kcrpodcast.com/toms-picture/)Flashback to earlier podcast interview about The Red Horse of Rev 6 Taking peace around the world, Demonstrations Berlin:  https://www.youtube.com/watch?v=Gvfj-_SFVBE (https://www.youtube.com/watch?v=Gvfj-_SFVBE) Moscow: https://www.youtube.com/watch?v=MDpjvhoFlbo (https://www.youtube.com/watch?v=MDpjvhoFlbo) Israel: https://www.youtube.com/watch?v=3cvagyW77o8 (https://www.youtube.com/watch?v=3cvagyW77o8) Australia: https://www.youtube.com/watch?v=pCocPugwhZw (https://www.youtube.com/watch?v=pCocPugwhZw) Baghdad: https://www.youtube.com/watch?v=TmIji99tZdY (https://www.youtube.com/watch?v=TmIji99tZdY) The Polarization of our SocietyHydrophobic - Definition adj.Repelling, tending not to combine with, or unable to dissolve in water. Example: Oil and water do not mix. This is what is happening in our society right now. 2 Timothy 3:1-9 (NIV)3 But mark this: There will be terrible times in the last days. 2 People will be lovers of themselves, lovers of money, boastful, proud, abusive, disobedient to their parents, ungrateful, unholy, 3 without love, unforgiving, slanderous, without self-control, brutal, not lovers of the good, 4 treacherous, rash, conceited, lovers of pleasure rather than lovers of God— 5 having a form of godliness but denying its power. Have nothing to do with such people. 6 They are the kind who worm their way into homes and gain control over gullible women, who are loaded down with sins and are swayed by all kinds of evil desires, 7 always learning but never able to come to a knowledge of the truth. 8 Just as Jannes and Jambres opposed Moses, so also these teachers oppose the truth. They are men of depraved minds, who, as far as the faith is concerned, are rejected. 9 But they will not get very far because, as in the case of those men, their folly will be clear to everyone. Terrible TimesPortland, OR- Nightly violent demonstrations towards the federal courthouse. https://www.youtube.com/watch?v=tJAcrffT9y8 (https://www.youtube.com/watch?v=tJAcrffT9y8) It seems like current videos posted on social media are edited to make law enforcement officers look like they are the problem.   CONTACT TOM DONNAN:Tom Donnan email: www.chataboutjesus.com (http://www.chataboutjesus.com/)

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.05.237966v1?rss=1 Authors: Lin, Y., Fichou, Y., Longhini, A. P., Llanes, L. C., Yin, Y., Bazan, G. C., Kosik, K. S., Han, S. Abstract: Amyloid aggregation of tau protein is implicated in neurodegenerative diseases, yet its facilitating factors are poorly understood. Recently, tau has been shown to undergo liquid liquid phase separation (LLPS) both in vivo and in vitro. LLPS was shown to facilitate tau amyloid aggregation in certain cases, while independent of aggregation in other cases. It is therefore important to understand the differentiating properties that resolve this apparent conflict. We report on a model system of hydrophobically driven LLPS induced by high salt concentration (LLPS-HS), and compare it to electrostatically driven LLPS represented by tau-RNA/heparin complex coacervation (LLPS-ED). We show that LLPS-HS promotes tau protein dehydration, undergoes maturation and directly leads to canonical tau fibrils, while LLPS-ED is reversible, remains hydrated and does not promote amyloid aggregation. We show that the nature of the interaction driving tau condensation is the differentiating factor between aggregation-prone and aggregation-independent LLPS. Copy rights belong to original authors. Visit the link for more info

Andrew and Ryan answer questions solicited from the Backpacking Light community on Twitter, Facebook, and Instagram. Covered in this episode:  Hydrophobic down technology  Solar panels and battery pack management  Favorite hiking books and movies  How to get a good night’s sleep in the backcountry  Hammock systems  DCF/eVent fabrics Appalachian Trail trip planning  And more!   Also in this episode:  Ryan and Andrew catch up on quarantine life  New favorite gear! Click here for show notes: https://backpackinglight.com/027-podcast-listener-questions This podcast is brought to you ad-free by the subscribing members of backpackinglight.com. Please leave us a review and rating, it helps other people find our show.

DWRs — or “Durable Water Repellent” coatings — play a huge role in the performance of your outdoor gear, and are used on nearly every waterproof garment on the market. But most DWRs are made with chemicals called PFCs, which can be harmful to you and the environment.Nikwax, however, makes products intended to extend the lifespan of outdoor gear, and none of their specialized cleaning, conditioning, or waterproofing products have ever used PFCs. So we talked with Heidi Allen from Nikwax about how DWRs work; the dangers of PFCs; how the industry is attempting to shift away from PFCs; garment care; and more. TOPICS & TIMES:Heidi’s background growing up off-the-grid (1:00)Durable Water Repellent (DWR) overview (2:54)DWRs vs. Membranes? (6:50)Hydrophobic vs. Oleophobic? (11:38)Why do clean garments perform better? (17:15)Alternatives to PFCs (19:06)Environmental & transparency initiatives at Nikwax (27:01)The future of DWRs (31:09)Páramo (33:30) See acast.com/privacy for privacy and opt-out information.

We are back with Mark and Dale Shaw of UltraTech. This couple’s viral video was so enormously successful, it practically crippled their sales department. They have a company culture that is extraordinary. We walked in the door and were treated like celebrities. Mark is most famously known for his Ted Talk video where he throws a bucket of red paint at a white canvas to demonstrate the genius of Ultra Ever Dry, the hydrophobic coating that makes water run away. Dale and Mark are also one of those couples who never planned on going into business together. Mark was a Mandarin-speaking economist who was going to make a killing in business with China. But the Love Canal environmental disaster made him want to save the world from toxic waste. Dale got involved because her husband and his business partners needed bookeeping. But…where do diapers that don’t smell fit into all of this?

Dale and Mark Shaw of Ultratech in Jacksonville, Florida have one of those stories about accidentally going into business together. Inspired by the Love Canal environmental disaster, Mark wanted to save the world from toxic chemicals. Inspired by some harebrained ideas they had, Dale wanted to save Mark and his partners from some lousy bookkeeping plans. 25 years later, Mark and Dale are a force in environmental compliance, spill containment and advanced technology products. Theirs is also a business that has had more than its 15 minutes of fame. They were responsible for a viral video that crippled their sales department. Mark and Dale are smart, fun and engaging—and have quite a story about being a couple in love and in business because of Love Canal.

Hydrophobic, or water-repellent soils are soils coated in organic compounds, which prevent water from properly infiltrating the soil. Usually affecting sandy soils, these compounds can come from plant wax and oils, or microorganisms in the soil, causing patchy and staggered crop establishment for grain growers. In this podcast, Dr Stephen Davies from WA's Department of Primary Industries and Regional Development talks to Lucinda Jose about outcomes from the Soil Constraints West project that can help growers better manage water-repellent soils. Further information: Dr Stephen Davies Soil Constraints West Initiative Department of Primary Industries and Regional Development 20 Gregory St., Geraldton WA 6530 m: 0408 439 497 email: stephen.davies@dpird.wa.gov.au Resources: AGRIC Managing soils > ROSA: https://www.agric.wa.gov.au/managing-soils/ranking-options-soil-amendments-tool AGRIC Managing soils > water repellence: https://www.agric.wa.gov.au/climate-land-water/soils/soil-constraints/water-repellence AGRIC Managing soils > soil compaction: https://www.agric.wa.gov.au/climate-land-water/soils/managing-soils/soil-compaction AGRIC Managing soils > soil acidity: https://www.agric.wa.gov.au/climate-land-water/soils/managing-soils/soil-acidity GRDC Initiatives > Non-wetting soils: https://grdc.com.au/research/trials,-programs-and-initiatives/non-wetting-soils

How sharp are your networking skills? Dr. Ivan Misner, Ph.D., author of Avoiding the Networking Disconnect and Founder and Chief Visionary Officer at BNI, explains how to build meaningful professional connections to boost sales. Then, Dropel Fabrics CEO, Sim Gulati, shares what it takes to innovate in one of the world’s oldest industries, textiles. Rounding out the hour, Co-founder and CEO of CreativeLive, Chase Jarvis, inspires us to pursue a passion-fueled career path - Listen now. [00:00:00] ‘Networking Disconnect’ Responsible for Flat Sales [00:04:50] Don’t Fall Victim to Ultimate Sales-Killer [00:11:31] Avoid Premature Sales Solicitation  [00:18:21] Invaluable Lessons from Leading Networking Guru [00:26:16] Dropel Fabrics Transforms Fashion Industry [00:33:21] It's Never Too Late to Make a Change

What is nanotechnology? An invitation to enter a new field of physics: A lecture on nanotechnology that Richard Feynman gave in 1959 (Zyvex) (http://www.zyvex.com/nanotech/feynman.html) Definition of 'nano' (Wikipedia) (https://en.wikipedia.org/wiki/Nano-) Nanotechnology (Wikipedia) (https://en.wikipedia.org/wiki/Nanotechnology) The National Nanotechnology Initiative (NNI) (http://www.nano.gov) @NNInanonews: Twitter feed of NNI (https://twitter.com/NNInanonews) Center for Responsible Nanotechnology (CRN) (http://crnano.org/whatis.htm) The billion year technology gap (The Daily Galaxy) (http://www.dailygalaxy.com/my_weblog/2009/11/the-billionyear-technology-gap-could-one-exist-the-weekend-feature.html) The Fermi death sentence (Nanotechnology Now) (http://www.nanotech-now.com/columns/?article=149) Explaining nanotechnology to a 5th grader (YouTube) (https://youtu.be/DAOFpgocfrg) Your fingernail grows a nanometre every second (NNCI) (http://www.nnci.net/what-nano) Bottom-up versus top-down approaches (Wikipedia) (https://en.wikipedia.org/wiki/Nanotechnology#Bottom-up_approaches) Meet the nanomachines that could drive a medical revolution (Phys.org) (https://phys.org/news/2016-04-nanomachines-medical-revolution.html) Nanoparticles (Wikipedia) (https://en.wikipedia.org/wiki/Nanoparticle) Scanning electron microscope (Wikipedia) (https://en.wikipedia.org/wiki/Scanning_electron_microscope) How to move an atom (IBM Research) (https://www.ibm.com/blogs/research/2013/05/how-to-move-an-atom/) 20 years of moving atoms one by one: Including how they made the IBM logo out of 35 xenon atoms (Wired) (https://www.wired.com/2009/09/gallery-atomic-science/) Scientists measure how light affects individual atoms for the first time (nanowerk) (http://www.nanowerk.com/nanotechnology-news/newsid=33617.php) Current applications of nanotechnology (Wikipedia) (https://en.wikipedia.org/wiki/Nanotechnology#Applications) How nanotechnology is changing the future of medicine (MUO) (http://www.makeuseof.com/tag/nanotechnology-changing-future-medicine/) Applications of nanotechnology in medicine (Australian Science) (http://www.australianscience.com.au/biology/applications-of-nanotechnology-in-medicine/) Convergence Science Network (http://www.convergencesciencenetwork.org.au) Stentrode (ABC, Catalyst) (http://www.abc.net.au/catalyst/stories/4519966.htm) The world's first international race for molecular cars, the Nanocar Race (Phys.org) (https://phys.org/news/2017-03-world-international-molecular-cars-nanocar.html) Nanoparticles & sunscreen (Cancer Council Australia) (http://www.cancer.org.au/preventing-cancer/sun-protection/nanoparticles-and-sunscreen.html) Titanium dioxide (Wikipedia) (https://en.wikipedia.org/wiki/Titanium_dioxide) Nanoparticles are all around us: Naturally-occurring vs man-made (sustainable nano) (http://sustainable-nano.com/2013/03/25/nanoparticles-are-all-around-us/) Nanoparticles in nature: Toxic or harmless? (EarthSky) (http://earthsky.org/human-world/nanoparticles-in-nature-toxic-or-harmless) Gold nanoparticles can be red or blue/purple (Wikipedia) (https://en.wikipedia.org/wiki/Colloidal_gold) "Properties such as melting point, fluorescence, electrical conductivity, magnetic permeability, & chemical reactivity change as a function of the size of the particle" (NNI) (https://www.nano.gov/nanotech-101/special) Buckminsterfullerene, or buckyballs (Wikipedia) (https://en.wikipedia.org/wiki/Buckminsterfullerene) Have buckminsterfullerenes (buckyballs) been put to any practical uses? (Scientific American) (https://www.scientificamerican.com/article/have-buckminsterfullerene/) It doesn't seem that any real use has been found for buckyballs yet (Wikipedia) (https://en.wikipedia.org/wiki/Buckminsterfullerene#Applications) Carbon fibre (Wikpedia) (https://en.wikipedia.org/wiki/Carbon_fibers) Carbon nanofibre (Wikipedia) (https://en.wikipedia.org/wiki/Carbon_nanofiber) Did Bucky Fuller really design a soccer ball? (treehugger) (https://www.treehugger.com/sustainable-product-design/did-bucky-fuller-really-design-soccer-ball.html) How can graphite & diamond be so different if they are both composed of pure carbon? (Scientific American) (https://www.scientificamerican.com/article/how-can-graphite-and-diam/) Spiders sprayed with carbon nanotubes spin superstrong webs (Phys.org) (https://phys.org/news/2015-05-spiders-carbon-nanotubes-superstrong-webs.html) Spiders ingest nanotubes, then weave silk reinforced with carbon (MIT Technology Review) (https://www.technologyreview.com/s/537301/spiders-ingest-nanotubes-then-weave-silk-reinforced-with-carbon/) Space elevator (Wikipedia) (https://en.wikipedia.org/wiki/Space_elevator) Sorry Johnny, carbon nanotubes may be too weak to get a space elevator off the ground

DAPF #109. Dark Angels & Pretty Freaks #109. We read emails, answer questions, Talk about hydrophobic kitty litter, Get called out by another podcast, Neil Dreams about the Property Brothers, and his small post bike ride dingus, and our 5 Favorite Things about Netflix.   Wanna join us for Vegas meet up 2017 or Jamaica cast 2017? email us for more info!   Want some FREE DAPF stuff? Send us your address and we will send you some goodies!   www.DarkAngelsandPrettyFreaks.com   Please check out our free app wherever you download your apps!

As Winter approaches in some parts of the world, so does the colder weather and the threat of ice on the roads and on your car windscreen. But help is at hand from Kansas State University's Alexander van Dyke. As he explains to Charis Lestrange, he's created what's known as a "biphilic" material that can stop frost from forming so easily on a surface. It consists of two types of material: one hydrophilic, which attracts water, and the other hydrophobic, or water-repelling. Placed in a certain pattern, these can keep water droplets moving so they don't have time to freeze... Like this podcast? Please help us by supporting the Naked Scientists

As Winter approaches in some parts of the world, so does the colder weather and the threat of ice on the roads and on your car windscreen. But help is at hand from Kansas State University's Alexander van Dyke. As he explains to Charis Lestrange, he's created what's known as a "biphilic" material that can stop frost from forming so easily on a surface. It consists of two types of material: one hydrophilic, which attracts water, and the other hydrophobic, or water-repelling. Placed in a certain pattern, these can keep water droplets moving so they don't have time to freeze... Like this podcast? Please help us by supporting the Naked Scientists

Description Not Provided.

A new breed of super metals, that are extremely water repellent have been created. Their potential applications range from rust and frost free aircraft to self-cleaning toilets. Danielle Blackwell spoke to Prof. Chunlei Guo from the University of Rochester to find out more... Like this podcast? Please help us by supporting the Naked Scientists

A new breed of super metals, that are extremely water repellent have been created. Their potential applications range from rust and frost free aircraft to self-cleaning toilets. Danielle Blackwell spoke to Prof. Chunlei Guo from the University of Rochester to find out more... Like this podcast? Please help us by supporting the Naked Scientists

Reviews of the YanTouch Ice Diamond speaker, a first look at the new Parrot Bebop drone from CES, the Nextbook 2-in-1 Windows 8.1 laptop/tablet, the Papago GoLife Smart Scale, and the Cavalier Hydrophobic T-Shirt. Host: Leo Laporte Guests: Carly Perkins, Fr. Robert Ballecer, SJ, Chad (OMGchad) Johnson, Shannon Morse, and Lisa Laporte Download or subscribe to this show at https://twit.tv/byb. We invite you to read, add to, and amend the wiki entry for this episode at wiki.twit.tv. Also, check out our transcripts. Thanks to CacheFly for the bandwidth for this show. Sponsor: smartthings.com/twit

Reviews of the YanTouch Ice Diamond speaker, a first look at the new Parrot Bebop drone from CES, the Nextbook 2-in-1 Windows 8.1 laptop/tablet, the Papago GoLife Smart Scale, and the Cavalier Hydrophobic T-Shirt. Host: Leo Laporte Guests: Carly Perkins, Fr. Robert Ballecer, SJ, Chad (OMGchad) Johnson, Shannon Morse, and Lisa Laporte Download or subscribe to this show at https://twit.tv/byb. We invite you to read, add to, and amend the wiki entry for this episode at wiki.twit.tv. Also, check out our transcripts. Thanks to CacheFly for the bandwidth for this show. Sponsor: smartthings.com/twit

Reviews of the YanTouch Ice Diamond speaker, a first look at the new Parrot Bebop drone from CES, the Nextbook 2-in-1 Windows 8.1 laptop/tablet, the Papago GoLife Smart Scale, and the Cavalier Hydrophobic T-Shirt. Host: Leo Laporte Guests: Carly Perkins, Fr. Robert Ballecer, SJ, Chad (OMGchad) Johnson, Shannon Morse, and Lisa Laporte Download or subscribe to this show at https://twit.tv/byb. We invite you to read, add to, and amend the wiki entry for this episode at wiki.twit.tv. Also, check out our transcripts. Thanks to CacheFly for the bandwidth for this show. Sponsor: smartthings.com/twit

Reviews of the YanTouch Ice Diamond speaker, a first look at the new Parrot Bebop drone from CES, the Nextbook 2-in-1 Windows 8.1 laptop/tablet, the Papago GoLife Smart Scale, and the Cavalier Hydrophobic T-Shirt. Host: Leo Laporte Guests: Carly Perkins, Fr. Robert Ballecer, SJ, Chad (OMGchad) Johnson, Shannon Morse, and Lisa Laporte Download or subscribe to this show at https://twit.tv/byb. We invite you to read, add to, and amend the wiki entry for this episode at wiki.twit.tv. Also, check out our transcripts. Thanks to CacheFly for the bandwidth for this show. Sponsor: smartthings.com/twit

- Carmakers Rebound After Tough Winter - SUVs Pass Sedans in Sales - New smart fortwo and forfour - 2016 Mazda2 - Nissan to Offer Replacement Battery Packs - Will Hydrophobic Coatings Catch On?

Down insulation is a touchy subject as more and more consumers become aware of the poor ethics some manufacturers have been accused of in recent times. Hydrophobic down is also a hot topic, offering new benefits where before it would have failed to insulate when damp. Ben Mainwaring from Rab UK joins us to discuss the practicalities of harvesting 'down', new developments and the long term effects of bird flu from 2012. Plus news of the BPL outdoor show coming in Spring 2014.

A breakthrough nanoscale coating could save you some trips to the drycleaners!

David Robinson explains the difference between spiders and insects, and takes a close look at how technology allows us to learn more about thie behaviour.

Transcript -- David Robinson explains the difference between spiders and insects, and takes a close look at how technology allows us to learn more about thie behaviour.

David Robinson explains the difference between spiders and insects, and takes a close look at how technology allows us to learn more about thie behaviour.

Transcript -- David Robinson explains the difference between spiders and insects, and takes a close look at how technology allows us to learn more about thie behaviour.

Transcript -- Bio-physicist Bob Suter shows how some spiders can move over a water surface.

Bio-physicist Bob Suter shows how some spiders can move over a water surface.

Bio-physicist Bob Suter shows how some spiders can move over a water surface.

Transcript -- Bio-physicist Bob Suter shows how some spiders can move over a water surface.

To become biologically active, most proteins need to fold into precise three dimensional structures. It has been well established that all the folding information is contained within the primary structure of a protein. However, the mechanisms utilized by proteins to avoid sampling the extraordinarily large amount of possible conformations during their folding process are just beginning to be understood. Molecular chaperones assist the folding of newly synthesized and denatured proteins in acquiring their native state in the crowded intracellular environment. As a nascent chain leaves the ribosome, it is captured first by the upstream chaperones and then possibly transferred to the downstream chaperonins. GroEL-GroES, the Hsp-60 of E.coli, is one of the best studied chaperone systems. An appreciable amount of data is available providing information regarding its structure and function. GroEL encapsulates the substrate into the central cavity where folding occurs unimpaired by aggregation and unwanted inter-molecular interactions. Nevertheless, many important aspects of the GroEL mechanism remain to be addressed. Some of the open questions we have addressed in this study include: In what conformation does a substrate protein bind to the apical domains of GroEL; how is it that GroEL is able to accelerate the rate of folding of certain proteins, and how do the conformational properties of the substrate change as it undergoes repeated cycling. By using ensemble FRET and Sp-FRET (Single Pair-Fluorescence Resonance Energy Transfer), we have probed the conformation of the model substrate DM-MBP (Double Mutant Maltose Binding Protein) during different stages of the functional cycle of GroEL. With Sp-FRET coupled to PIE (Pulsed Interleaved Excitation), we have been able to explore the heterogeneity of the GroEL bound substrate protein and observed a bimodal conformational distribution. One of the two populations is as compact as the native state, whereas the other is as extended as the unfolded protein in denaturant. This unfolding is a local phenomena and can also be observed when the substrate is transferred from DnaK/J system (bacterial Hsp70) to GroEL, indicating the possibility of the existence of this conformational heterogeneity in vivo as the protein follows the cellular chaperone pathway. Subsequent to GroEL binding, there is a transient expansion of the protein upon binding of ATP to GroEL, followed by compaction when GroES triggers the encapsulation of the protein inside the chaperonin cage. This transient expansion is however found not to be a necessary event for the rate acceleration of DM-MBP folding, since ADP-AlFx (transition state analogue of ATP hydrolysis) results in a much slower rate of expansion, which does not cause a change in the folding rate. Anisotropy measurements, probing the freedom of motion of different regions of the GroEL bound protein, revealed that there is a segmental release of the substrate protein from the GroEL surface upon binding of ATP and GroES. As a consequence, the hydrophobic collapse of the protein upon encapsulation by GroES follows a step-wise mechanism. In this process, less hydrophobic regions are released upon binding of ATP, prior to more hydrophobic ones which are released only by GroES binding. Thus, the order of Hydrophobic collapse is reversed as compared to spontaneous folding possibly resulting in conformationally different folding intermediates. Evidence that the folding pathway inside the cage differs from that of spontaneous folding was obtained by observing the effect of external perturbations (e.g. mutations in substrate protein and use of different solvent conditions) on the rate of spontaneous and GroEL assisted folding reactions. These two folding reactions respond differently to the introduced perturbations. Kinetic data obtained from ensemble FRET measurements suggest that the conformation of refolding intermediate is altered by the GroEL cavity, which leads to a folding pathway that is different from the spontaneous refolding pathway. In summary, this study revealed significant novel aspects of the GroEL folding mechanism and provided insights into the basis of rate acceleration of the substrate protein by the chaperonin. This work may thus contribute to advance our fundamental knowledge of the chaperonin system and the basic mechanism of protein folding.

The goal of the thesis was to analyze the impact of the formulation conditions on the stabilization of a hydrophobic cytokine. A standard way to formulate the cytokine at physiological pH is using Human Serum Albumin (HSA) as excipient. Based on a lyophilized formulation with mannitol as bulking agent and HSA as stabilizer analogous to commercially available systems, the impact of HSA-stabilizers, NaCl and pH on particle formation and stability of the cytokine in the liquid state was elucidated. As NaCl can impact the freezing and lyophilization behavior, the impact of NaCl on the behavior of mannitol-HSA placebo mixtures based on the cytokine-HSA formulations was studied. The goal was to understand how freezing, lyophilization and a subsequent storage of the formulations are influenced by NaCl and the HSA-stabilizers. The use of HSA as excipient is related to the risk of blood born pathogens, enhanced immunogenicity, as well as to analytical difficulties. Therefore, approaches to replace HSA in the cytokine formulation and to achieve stable HSA-free formulations were developed. For the lyophilized formulations HSA was replaced by sucrose as amorphous stabilizer and the physico-chemical properties of the system mannitol–sucrose during freezing and lyophilization were analyzed. To achieve a stable HSA-free formulation, cytokine adsorption and its low solubility were the major issues that had to be overcome. Overall, it was feasible to stabilize the cytokine without the use of HSA at low pH as liquid and lyophilized formulation. By using glass type I+ vials, respectively adding polysorbate 20 it was possible to minimize protein adsorption. Thus, the studies provided an extensive characterization of the hydrophobic cytokine, its stabilization with HSA and the pH dependent instability of HSA-containing systems. As an alternative a stable HSA-free formulation for the cytokine could be presented. Especially for the lyophilized formulations it could be shown that subtle changes of excipients e.g. in the NaCl content can have a detrimental impact.

Background: Abnormalities of the intracellular metabolism of the hydrophobic surfactant proteins SP-B and SP-C and their precursors may be causally linked to chronic childhood diffuse lung diseases. The profile of these proteins in the alveolar space is unknown in such subjects. Methods: We analyzed bronchoalveolar lavage fluid by Western blotting for SP-B, SP- C and their proforms in children with pulmonary alveolar proteinosis ( PAP, n = 15), children with no SP- B ( n = 6), children with chronic respiratory distress of unknown cause ( cRD, n = 7), in comparison to children without lung disease ( n = 15) or chronic obstructive bronchitis ( n = 19). Results: Pro-SP-B of 25 - 26 kD was commonly abundant in all groups of subjects, suggesting that their presence is not of diagnostic value for processing defects. In contrast, pro-SP-B peptides cleaved off during intracellular processing of SP- B and smaller than 19 - 21 kD, were exclusively found in PAP and cRD. In 4 of 6 children with no SP- B, mutations of SFTPB or SPTPC genes were found. Pro-SP-C forms were identified at very low frequency. Their presence was clearly, but not exclusively associated with mutations of the SFTPB and SPTPC genes, impeding their usage as candidates for diagnostic screening. Conclusion: Immuno-analysis of the hydrophobic surfactant proteins and their precursor forms in bronchoalveolar lavage is minimally invasive and can give valuable clues for the involvement of processing abnormalities in pediatric pulmonary disorders.

Sat, 5 Dec 1992 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7630/1/Neupert_Walter_7630.pdf Horwich, Arthur; Hartl, Franz-Ulrich; Neupert, Walter; Martin, Jörg; Clark, Deborah J.; West, Ann H.