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For Monday 3rd August 2026, Carl Munson's Good Morning Portugal! news reports that Prime Minister Luís Montenegro has confirmed Portugal's support for an emergency EU interior ministers' meeting on Tuesday to address the migration surge at the Ceuta border, calling for a coordinated European response. Other headlines include a fuel-price split (petrol falling while diesel rises), an unprecedented surge in rental demand in Coimbra, an EU warning to Portugal over housing shortages and healthcare access, the AIMA backlog task force reaching a 20% reduction milestone (though hundreds of thousands of cases remain), northern Portugal preparing for a rare total solar eclipse on 12 August, updated inter-island airport fees in the Azores, confirmed autumn “Moving to Portugal” roadshow dates in the UK and Ireland, and the construction sector facing a crisis due to tightened immigration rules.#GoodMorningPortugal #PortugalNews #Ceuta #Migration #FuelPrices #CoimbraRentals #HousingCrisis #AIMA #SolarEclipse #Azores #MovingToPortugal #ConstructionCrisis #Portugal2026Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.Get help moving to and living in Portugal
Mexico's proposed workweek reduction marks one of the most significant labor law developments in recent years. In this episode, we examine the key changes under the reform, discuss whether additional legislative developments are expected, and explore the practical challenges HR and labor relations teams may face as they prepare for implementation. Host: Alexandra Aguilar Garcia (email) (BLP / Costa Rica)Guest Speaker: Samuel Flores (email) (Santamarina + Steta, S.C. / Mexico)Support the showRegister on the ELA website here to receive email invitations to future programs.
In this episode of the Heart podcast, Digital Media Editor, Professor James Rudd, is joined by Dr Sharon Ayayo from the University of Manchester, UK. They discuss her analysis of the MINAP database that showed a significant improvement in survival after heart attack in England and Wales, and tried to explain why this had occurred - was it more effective medication, greater use of coronary intervention or something else. If you enjoy the show, please leave us a positive review wherever you get your podcasts. It helps us to reach more people - thanks! Link to published paper: https://heart.bmj.com/content/112/8/446
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Georgia Ag Commissioner Tyler Harper calls for the U.S. Trade Representative to prioritize protections for American specialty crop producers, and China sharply reduced soybean imports from the U.S. in June, while purchases from Brazil continued to climb.
AgWest Farm Credit is awarding over $3 million to 48 organizations in communities throughout the West, and China sharply reduced soybean imports from the U.S. in June, while purchases from Brazil continued to climb.
CardioNerds (Drs. Apoorva Gangavelli, Jenna Skowronski, and Hannah Every) discuss the continuum of prevention and heart failure with Drs. Anu Lala and Martha Gulati. Grounded in a clinical case of a 55-year-old woman with uncontrolled hypertension, type 2 diabetes, and obesity who is on the trajectory toward heart failure, this episode unpacks a paradigm-shifting framework from a joint HFSA/ASPC Scientific Statement. The discussion explores how prevention should not be siloed from heart failure management but rather integrated across a patient’s lifespan—from primary prevention in at-risk individuals, to secondary prevention in those with established heart failure, to tertiary prevention in patients with advanced therapies such as LVADs and heart transplantation. The experts highlight the importance of aggressive risk factor management, biomarker-guided screening, the AHA’s Life’s Essential 8, and the need for multidisciplinary collaboration and systems-level change to shift heart failure care from reactive to proactive. Audio editing for this episode was performed by CardioNerds Intern, Dr. Julia Marques Fernandes. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Systemic inflammatory diseases are associated with an elevated CVD risk that has significant implications for early detection, risk Heart failure prevention is a continuum, not a checkpoint. Prevention applies at every stage—from at-risk (Stage A) through advanced/post-transplant care—and every clinical encounter is an opportunity to intervene. The AHA’s Life’s Essential 8 (diet, physical activity, nicotine exposure, sleep, BMI, blood lipids, blood glucose, blood pressure) forms the foundation at every stage. Hypertension carries the highest population-attributable risk for heart failure of any modifiable risk factor. In the Framingham Heart Study, 91% of patients with newly diagnosed HF had pre-existing hypertension. The SPRINT trial demonstrated a 38% reduction in HF incidence with intensive blood pressure targets (30 ng/L or NT-proBNP >125 ng/L) identify individuals at heightened risk for progression to symptomatic HF. The ACC/AHA/HFSA guidelines give a Class IIa recommendation for natriuretic peptide screening in at-risk patients. Urine albumin-to-creatinine ratio (UACR) is an underutilized screening tool that provides additional insight into CKM risk. The heart failure label does not close the prevention window—it accentuates it. Secondary prevention through GDMT optimization (quadruple therapy in HFrEF) and continued risk factor management remains critical. Tertiary prevention extends to post-LVAD and post-transplant patients, where hypertension, diabetes, obesity, and CKD management remain essential to long-term outcomes. Show notes For a comprehensive review, please review the full HFSA/ASPC Joint Scientific Statement: Lala A, Beavers C, Blumer V, et al. The Continuum of Prevention and Heart Failure in Cardiovascular Medicine. J Card Fail. 2026;32:75-105. doi:10.1016/j.cardfail.2025.06.013 1. What is the “continuum of prevention” framework, and how does it differ from traditional approaches to heart failure prevention? Historically, prevention and heart failure management have been treated as separate disciplines—primary prevention handled by preventive cardiologists and treatment managed by heart failure specialists. This joint HFSA/ASPC Scientific Statement reframes prevention as a dynamic, continuous process that spans a patient’s entire lifespan, regardless of HF stage or ejection fraction. The framework maps onto the ACC/AHA HF staging system: Primary prevention targets Stage A (“at risk”) and Stage B (“pre-HF”) patients to reduce the burden of incident HF. Secondary prevention targets Stage C (symptomatic) and Stage D (advanced) patients to reduce the impact of established HF through GDMT optimization and ongoing risk factor management. Tertiary prevention encompasses risk factor management in patients with LVADs or heart transplants—populations where hypertension, diabetes, and obesity still drive outcomes. The Central Figure of the statement illustrates that Life’s Essential 8 (blood pressure and lipid control, diabetes management, exercise, sleep, smoking cessation, weight management, and diet/nutrition counseling) forms the foundation at every stage, with pharmacologic and device-based therapies layered on top as disease progresses (Figure) 2. How do traditional risk factors drive heart failure, and what should clinicians prioritize? Hypertension carries the greatest population-attributable risk for HF. In the Framingham Heart Study (N=5,143), HTN was associated with a 2- to 3-fold increased risk of HF, with a population-attributable risk of 39% in men and 59% in women. The SPRINT trial showed a 38% reduction in HF incidence and 25% reduction in the primary composite outcome with intensive BP targets (30 ng/L or NT-proBNP >125 ng/L) are associated with heightened risk for progression to symptomatic HF. In the ARIC study, incorporating NT-proBNP reclassified 20% of older adults without HF into Stage B. Factors that affect interpretation include age, sex, obesity (lower values), and CKD (higher values). High-sensitivity cardiac troponin (hs-cTn): Concentrations above the 99th percentile are now included in the definition of Stage B HF. Troponin testing may complement natriuretic peptides, particularly when BNP/NT-proBNP values are ambiguous. Risk scores: The PCP-HF equation predicts 10-year HF risk using traditional risk factors plus QRS duration. The AHA PREVENT score incorporates HF risk calculation and includes markers of kidney function (albuminuria, eGFR), though it may underestimate risk in men and Black adults. The CKM syndrome staging framework (Stages 0–4) provides a holistic approach to assessing systemic cardiovascular-kidney-metabolic risk. 4. What are the key nontraditional risk factors and cross-cutting themes in heart failure prevention? Genetics: Pathogenic cardiomyopathy variants exist in ~1 in 200 individuals in the general population. The HFSA and ACMG recommend cascade testing to identify at-risk family members. Polygenic risk scores for dilated cardiomyopathy show a 3.8-fold risk for DCM in the top 10th percentile compared with the median. Sex-specific considerations: Women have 2.8 times the odds of developing HFpEF, while men have similarly increased odds of HFrEF. A complete obstetric/gynecologic history is essential—preeclampsia is associated with a 4-fold increased risk of HF. Peripartum cardiomyopathy requires intentional screening in high-risk populations. Cardiotoxic exposures: Clinicians should be aware of medications that cause direct myocardial toxicity (e.g., anthracyclines, trastuzumab, tyrosine kinase inhibitors). A team-based approach with pharmacists can help optimize medication selection and risk factor modification. Social determinants of health: Environmental exposures (air pollution, arsenic, lead, cadmium), food insecurity, financial instability, and limited healthcare access contribute to HF risk and progression. Equity-focused, risk-based prevention strategies are needed. Psychological health: Depression is common in HF and independently associated with worse outcomes. Screening with brief questionnaires (e.g., PHQ-2) is recommended. Meditation, spirituality, and holistic wellness approaches remain underutilized. 5. What systems-level and policy changes are needed to move the needle on heart failure prevention? Multidisciplinary HF prevention clinics that bring together preventive cardiologists, HF specialists, endocrinologists, nephrologists, dietitians, pharmacists, exercise physiologists, and genetic counselors are advocated by the statement. EHR-embedded risk stratification could proactively flag patients on a trajectory toward HF—analogous to sepsis alerts or fall risk flags—enabling earlier intervention, particularly for patients who may not reach a cardiologist. Cardiac rehabilitation remains underutilized, particularly in HFrEF (Class 2b recommendation) and HFpEF (not yet covered by Medicare). The HF-ACTION trial showed quality-of-life benefits, and the REHAB-HF trial showed particular benefit in older patients with HFpEF. Policy priorities include expanding insurance coverage for preventive screening and novel therapies (SGLT2i, GLP-1 RAs, nsMRAs), reducing clinical inertia through team-based care models with closer follow-up intervals, and ensuring equitable access to evidence-based therapies across diverse populations. Digital health and AI hold promise for personalized risk prediction, remote monitoring (e.g., wearable devices, implantable PA pressure monitors), and virtual cardiac rehabilitation to overcome access barriers. Figure Lala A, Beavers C, Blumer V, et al. The continuum of prevention and heart failure in cardiovascular medicine: a joint scientific statement from the Heart Failure Society of America and the American Society for Preventive Cardiology. J Card Fail. 2026;32(1):75-105. doi:10.1016/j.cardfail.2025.06.013) References Key references are bolded. Lala A, Beavers C, Blumer V, et al. The continuum of prevention and heart failure in cardiovascular medicine: a joint scientific statement from the Heart Failure Society of America and the American Society for Preventive Cardiology. J Card Fail. 2026;32(1):75-105. doi:10.1016/j.cardfail.2025.06.013 Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e895-e1032. doi:10.1161/CIR.0000000000001063 Lloyd-Jones DM, Allen NB, Anderson CAM, et al. Life’s Essential 8: updating and enhancing the American Heart Association’s construct of cardiovascular health: a presidential advisory from the American Heart Association. Circulation. 2022;146(5):e18-e43. doi:10.1161/CIR.0000000000001078 SPRINT Research Group, Wright JT Jr, Williamson JD, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103-2116. doi:10.1056/NEJMoa1511939 Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. JAMA. 1996;275(20):1557-1562. doi:10.1001/jama.1996.03530440037034 Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288(23):2981-2997. doi:10.1001/jama.288.23.2981 Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med. 2000;342(3):145-153. doi:10.1056/NEJM200001203420301 Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373(22):2117-2128. doi:10.1056/NEJMoa1504720 Anker SD, Butler J, Filippatos G, et al. Empagliflozin in heart failure with a preserved ejection fraction. N Engl J Med. 2021;385(16):1451-1461. doi:10.1056/NEJMoa2107038 Solomon SD, McMurray JJV, Claggett B, et al. Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. N Engl J Med. 2022;387(12):1089-1098. doi:10.1056/NEJMoa2206286 Filippatos G, Anker SD, Agarwal R, et al. Finerenone reduces risk of incident heart failure in patients with chronic kidney disease and type 2 diabetes: analyses from the FIGARO-DKD trial. Circulation. 2022;145(6):437-447. doi:10.1161/CIRCULATIONAHA.121.057983 Solomon SD, McMurray JJV, Vaduganathan M, et al. Finerenone in heart failure with mildly reduced or preserved ejection fraction. N Engl J Med. 2024;391(16):1475-1485. doi:10.1056/NEJMoa2407107 Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023;389(24):2221-2232. doi:10.1056/NEJMoa2307563 Deanfield J, Verma S, Scirica BM, et al. Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial. Lancet. 2024;404(10454):773-786. doi:10.1016/S0140-6736(24)01498-3 Kosiborod MN, Abildstrøm SZ, Borlaug BA, et al. Semaglutide in patients with heart failure with preserved ejection fraction and obesity. N Engl J Med. 2023;389(12):1069-1084. doi:10.1056/NEJMoa2306963 Ndumele CE, Neeland IJ, Tuttle KR, et al. A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American Heart Association. Circulation. 2023;148(20):1636-1664. doi:10.1161/CIR.0000000000001175 Khan SS, Matsushita K, Sang Y, et al. Development and validation of the American Heart Association’s PREVENT equations. Circulation. 2024;149(6):430-449. doi:10.1161/CIRCULATIONAHA.123.067626 Khan SS, Ning H, Shah SJ, et al. 10-year risk equations for incident heart failure in the general population. J Am Coll Cardiol. 2019;73(19):2388-2397. doi:10.1016/j.jacc.2019.02.057 Bozkurt B, Fonarow GC, Goldberg LR, et al. Cardiac rehabilitation for patients with heart failure: JACC expert panel. J Am Coll Cardiol. 2021;77(11):1454-1469. doi:10.1016/j.jacc.2021.01.030 Packer M. Leptin-aldosterone-neprilysin axis: identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity. Circulation. 2018;137(15):1614-1631. doi:10.1161/CIRCULATIONAHA.117.032474 Lala A, Tayal U, Hamo CE, et al. Sex differences in heart failure. J Card Fail. 2022;28(3):477-498. doi:10.1016/j.cardfail.2021.10.006 Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure. Eur J Heart Fail. 2021;23(3):352-380. doi:10.1002/ejhf.2115 Hershberger RE, Givertz MM, Ho CY, et al. Genetic evaluation of cardiomyopathy—a Heart Failure Society of America practice guideline. J Card Fail. 2018;24(5):281-302. doi:10.1016/j.cardfail.2018.03.004 Levine GN, Cohen BE, Commodore-Mensah Y, et al. Psychological health, well-being, and the mind-heart-body connection: a scientific statement from the American Heart Association. Circulation. 2021;143(10):e763-e783. doi:10.1161/CIR.0000000000000947 Ezekowitz JA, Colin-Ramirez E, Ross H, et al. Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial. Lancet. 2022;399(10333):1391-1400. doi:10.1016/S0140-6736(22)00369-5
After 3 miscarriages, Jayme found out she was pregnant with twins. They were overjoyed, but then around 17 weeks a poor prenatal diagnosis was found in one baby, and eventually an even worse condition TTTS (twin to twin transfusion syndrome) was found and one baby was actively dying
Peter Huessy. The discussion continues with a focus on films like Fail-Safe and The Day After. Huessy highlights how these movies influenced public perception and presidential policy, including Ronald Reagan's drive for arms reduction. They reflect on the devastating human and economic consequences of a potential nuclear exchange. (16)2945 NAGASAKI
Join lifelong friends and co-hosts Rick Hogg (founder of War HOGG Tactical) and Mark Kelley (founder of Kelley Defense) on the On The Range Podcast as they sit down with special guest Chase Greene, Sales Manager at CanCo Silencers. In this high-value episode, Chase shares expert insights into CanCo's cutting-edge suppressor technology. Learn about their tough, lightweight, ultra-quiet, and user-serviceable designs that deliver industry-leading sound suppression while maintaining durability and ease of maintenance. The conversation covers real-world suppressor performance in tactical training, law enforcement, military applications, competitive shooting, and recreational range use — plus tips on integration, maintenance, and maximizing your suppressed firearms. With decades of combined Special Operations, law enforcement, K9 handling, and firearms training experience between the hosts and guest, this episode delivers authentic, battle-tested perspectives on suppressor innovation, quiet shooting advantages, and how the right silencer can improve safety, accuracy, and enjoyment on the range. Whether you're a serious shooter, firearms instructor, tactical professional, or suppressor enthusiast, this is a must-listen episode packed with actionable knowledge from one of the industry's passionate voices.Listen or Watch Now: On The Range Podcast Official Site YouTube Spotify Apple Podcasts Join the On The Range Podcast CREW for exclusive member-only training content, live Q&As, early access, and more ways to be 1% better every day. SEO Keywords (for metadata/tags): On The Range Podcast, Rick Hogg, Mark Kelley, Chase Greene CanCo Silencers, suppressors, silencers, firearm suppressors, CanCo Silencers, suppressor technology, tactical training podcast, firearms training, War HOGG Tactical, Kelley Defense, quiet shooting, silencer podcast, NFA suppressors, tactical gear.
Dyrevelferd er et tema som engasjerer mange, og samtidig er forskning på dyr fortsatt viktig innen både medisin, veterinærmedisin og havbruk. For å sikre at dyr brukes på en mest mulig ansvarlig måte, bygger moderne forskning på prinsippet om de tre R-ene: Replacement, Reduction og Refinement – altså erstatning, reduksjon og forbedring.I 2026 besluttet den norske regjeringen å opprette et nasjonalt 3R-senter under Mattilsynet. Senteret skal bidra til å styrke arbeidet med alternativer til dyreforsøk, redusere bruken av forsøksdyr og forbedre dyrevelferden når dyr brukes i forskning. Målet er å styrke arbeidet med alternativer til dyreforsøk. Det vil bli utarbeidet en helhetlig kunnskapsoppsummering om alternativer til dyreforsøk og arbeid med 3R i Norge. Arbeidet vil utføres av Veterinærinstituttet i samarbeid med relevante aktører.I denne episoden skal vi se nærmere på hva de tre R-ene betyr i praksis, hvorfor Norge nå får et eget 3R-senter, og hvilke utfordringer og muligheter som ligger foran oss. Med oss har vi Adrian Smith, sekretær i Norecopa – Norges nasjonale kompetanseplattform for de tre R-ene. Bryndis Holm, kommunikasjonsrådgiver på Veterinærinstituttet, er programleder i podcasten. Hosted on Acast. See acast.com/privacy for more information.
Discover the profound impact of Vitamin K1 on respiratory health in this breakdown of a decade-long study involving over 179,000 adults. While Vitamin K2 often steals the spotlight for bone and heart health, new data suggests K1 is the "ruler of the realm" when it comes to protecting the lungs and reducing the risk of chronic lung disease (COPD).In this episode, we explore the science behind the "Matrix GLA Protein" (MGP), how leafy greens like kale and spinach act as "Green Power" for your lungs' elasticity, and why current daily recommendations for Vitamin K might be falling short of optimal levels.Key Takeaways:The K1 vs. K2 Difference: Why K1 is essential for lung function and fiber elasticity.COPD Risk Reduction: A 16% lower risk found in those with the highest K1 intake.The "Trampoline" Effect: Visualizing how K1 protects the elastic structures that help you breathe.Practical Serving Sizes: How much cooked kale or spinach is needed to reach optimal levels.Timestamps0:00 The Profound Impact of Vitamin K1 vs K2 on Lungs0:36 Analyzing the Study Data: Q1 vs Q5 Intakes 1:13 Is the 70mcg RDI Optimal or Just a Minimum? 1:44 Lung Function and the Difference in Breathing Depth 2:15 The Matrix GLA Protein (MGP): Protecting Lung Elasticity2:30 Green Power: Tracking 179,000 Adults Over a Decade 3:14 16% Reduction in COPD Risk Explained3:55 How K1 Activates Protective Elastic Fibers 4:36 Visual Comparison: Healthy vs. Stiff Lung Function5:01 Detailed Look at Matrix GLA Protein Activation 5:28 Raw vs. Cooked Kale: Maximizing Your K1 Intake 5:56 Study Validation: Hazard Ratios and Confidence Intervals 6:16 K1 for Lungs and Clotting vs. K2 for Bones and Arteries6:56 Addressing the "Healthy Volunteer Effect" in the UK Biobank 7:29 Terminology Glossary and Final Summary 8:10 Are Current RDI Guidelines Too Low for Respiratory Health?#VitaminK1 #COPD #LungHealth #MatrixGlaProtein #STEM #NutritionScience #RespiratoryWellness #HealthyAging #Emphysema #TheCatalystFormal Citation (AMA Style)Li C, Pokharel P, Sim M, et al. Dietary vitamin K intakes, chronic obstructive pulmonary disease, adult asthma, and lung function: a prospective cohort study in the UK Biobank. Am J Clin Nutr. 2026;123(101324):1-12. doi:10.1016/j.ajcnut.2026.101324Medical & Legal DisclaimerDisclaimer: The information provided here is for educational and informational purposes only and is not intended as medical advice. Dietary changes, particularly those involving vitamin K intake, can interact significantly with anticoagulant medications (blood thinners). Always consult with your physician or a qualified healthcare provider regarding a medical condition, diet, or treatment. The narrator and analysis team (The Catalyst) do not monetize this information and provide it as a public service.vitamin K1, K1 VS. COPD, lung blueprint, K1 lung health, COPD prevention, vitamin K-dependent proteins, Matrix Gla Protein, MGP, lung volume, pulmonary function, FEV1, FVC, spirometry, UK Biobank, dietary phylloquinone, green leafy vegetables, lung structure preservation, elastic fiber degradation, emphysema, nutritional epidemiology, chronic respiratory disease, respiratory wellness, Catalyst analysis, Ralph Turchiano, high-energy science, STEM education, non-monetized data.
Prof. Andrew Huberman explains that addiction and trauma lock the brain into a dysregulated reward-stress cycle. - The prefrontal cortex (responsible for self-control) becomes weakened by chronic substance use or trauma-induced hyperarousal. - The limbic system (craving, fear, grief) becomes overactive. Telling someone with severe addiction or grief to “just use willpower” is like asking someone with a broken leg to “just walk.” The neural hardware is compromised. What a “higher power” actually does (scientifically)When people hand over control to God, the universe, or an Anonymous-Alcoholic-style higher power, several measurable things happen:1. Reduction in cognitive load Constantly fighting urges or intrusive grief thoughts exhausts mental resources. Belief in a higher power allows the brain to offload the monitoring and control to an external entity, freeing up prefrontal capacity.2. Activation of parasympathetic (calming) systems Prayer, meditation, or surrender triggers the vagus nerve, lowering cortisol and heart rate. This is measurable via heart rate variability (HRV).3. Increased social and group effect In an Anonymous Alcoholic (AA) or group therapy, the “higher power” is often channeled through the group's shared belief. Mimicry, ritual, and accountability activate the brain's social reward system (oxytocin, endogenous opioids), replacing the addictive substance's effect.4. Meaning-making and narrative reconstruction After immense loss (e.g., a child's death), the brain's default mode network generates rumination and despair. A higher power reframes the loss as part of a larger story—reducing the “shattered assumptions” effect that causes prolonged grief disorder.The two-path framing Path 1: Trauma-release therapy (Humaniversity's 14-day intensive, EMDR, somatic experiencing) Works when the addiction is primarily driven by unprocessed trauma. Success rate can be high (80–90% in that specific model) because it “resets the emotional charge” behind the craving.Path 2: Spiritual surrender (AA, religious faith, higher power) Works especially when:Trauma therapy alone didn't stick, orThe loss is so profound that no “technique” can touch it (e.g., losing a child), orThe person has failed repeatedly at self-control.Science cannot “prove” God, but it can prove that “the act of believing and surrendering” changes brain function in ways that enable recovery. Practical steps for someone facing addiction or immense lossFor addiction (alcohol, drugs):1. Try intensive trauma-release therapy first (14–30 days, group-based, 24/7 support if possible). 2. If that fails or is unavailable, go to AA/12-step. 3. In AA: pick a “higher power” you can accept (it does not need to be a deity—could be nature, the group itself, love, or simply “reality”). 4. When urge hits: pause, say aloud “I cannot do this alone,” and ask that higher power for 10 minutes of relief. That pause often resets the craving circuit.For immense loss (e.g., child's death):- Talk therapy alone often cannot touch this level of grief—it's not pathological, it's existential. - Surrender practice: “I will never make sense of this. I cannot carry this alone. I give this weight to [God/life/the universe].” - Ritualize it: light a candle each morning, and mentally place the child's memory and your pain into the higher power's hands. - Over weeks, brain activity shifts from hypervigilant grief (amygdala) to reflective remembrance (prefrontal-hippocampal integration). Scientific bottom lineYes, a higher power works as a neurocognitive leverage point—not because the higher power is empirically verified, but because the *act of surrender* bypasses the exhausted willpower system and recruits brain circuits of trust, safety, and social connection.If you or someone you know is struggling, combining both paths (trauma therapy + spiritual surrender) is often optimal, so I did. And if you cannot believe in any higher power, you can still use a “higher purpose” (e.g., serving others, protecting a loved one, creating art) to achieve the same neural offloading effect.
The GOAL Podcast - Official Podcast of Gun Owners' Action League
Diving into the proposals for deer culling and tick reduction on MV. Also, the Supreme Court is taking up two important AWB cases, but combining them into one. What that means, plus news and more! Also on YouTube: https://youtu.be/OTSrLI3ewqo
Paul Booth is a performance nutritionist and exercise physiologist who works with elite ultra-endurance athletes and teams, including the Salomon International team, and was the nutritionist behind both the men's and women's UTMB winners in 2025, Tom Evans and Ruth Croft. We cover the science and practice of fuelling: how many carbs you actually need, why the high-carb trend has run ahead of the evidence, and how to get hydration and electrolytes right for triathlon and ultra-endurance racing. HIGHLIGHTS AND KEY TOPICS: Why Paul calls himself a "90-gram carb guy" and where the carb ceiling actually sits What the science says about 90 versus 120 grams of carbohydrate per hour The physiology of carbohydrate absorption, and how to work out your own intake for an Ironman without lab testing Gut training: building tolerance to carbs and fluid in the weeks before a race A simple DIY method to work out your sweat rate and fluid needs Why hydration, not carbs, is behind most race-day gut problems Electrolytes: what the evidence supports and what is mostly marketing Fuelling through heat, altitude and ageing, plus listener questions on glycogen-depleted training, honey and more SHOWNOTES, LINKS, RESOURCES AND RELATED EPISODES: Follow Paul and Performance Gains Nutrition on his website and Instagram The shownotes for today's episode can be found here. The full podcast episode archives (including category filters) can be found here. Related episodes: Carbohydrates, science and practice with Tim Podlogar, PhD | EP#354 Nutrition and hydration data from Kona and 70.3 Worlds with Andy Blow | EP#365 Aerobic training and testing with Scott Johnston | EP#326 Richard Laidlow | EP#403 Studies discussed: Fuelled or Fooled? Examining the Evidence and Mechanisms Behind Ultra-High Carbohydrate Intake in Endurance Athletes - Plews et al. 2026 Graded Carbohydrate Ingestion up to 120 g/h Attenuates the Reduction in Critical Power Following 3 h of Moderate-Intensity Exercise in a Dose-Dependent Manner - Norte et al. 2026 13C-labelled glucose-fructose show greater exogenous and whole-body CHO oxidation at 120 vs 60 & 90 g/h in elite male marathoners - Ravikanti et al. 2025 Exogenous Glucose Oxidation During Exercise Is Positively Related to Body Size - Ijaz et al. 2024 Fructose-maltodextrin ratio governs exogenous and other CHO oxidation and performance - O'Brien et al. 2013 Nutritional intake and gastrointestinal problems during competitive endurance events - Pfeiffer et al. 2012 Modelling sodium requirements of athletes across exercise scenarios – when to test and target, or season to taste - McCubbin 2022 Could It Bee? Honey Ingestion Induces Comparable Metabolic Responses to a Traditional Carbohydrate Sports Product - Fortis et al. 2025 SPONSORS: Precision Fuel & Hydration produce our favourite gels, sports drinks, and electrolyte and carbohydrate products here at That Triathlon Show and Scientific Triathlon. Use the free Fuel & Hydration Planner to get a personalised plan for your carbohydrate, sodium and fluid intake in your next event, and get 15% off your first 2026 order by using the code TTS2026 at checkout. Rouvy is hands down the most complete indoor cycling platform for triathletes. Among their thousands of beautiful bike courses from all around the world, all filmed in stunning quality, they have over 75 IRONMAN and IRONMAN 70.3 race courses plus 20+ Challenge Family courses, so you can pre-ride your race from home. Real gradients, real visuals, and real feel! Head to rouvy.com and use the code TTS to get your first month free on top of a 7-day free trial. Effortless Swimming produce the best swim goggles for triathletes and open water swimmers. Their NanoClear anti-fog lenses give you clear, fog-free vision that lasts and doesn't wear off. Don't let foggy or leaky goggles ruin another swim. Go to shop.effortlessswimming.com and use the code TTS15 to get 15% off your goggles, and get a free two-month Effortless Swimming course membership. ZenAI is the next frontier of podcasting. It lets you turn your ideas into a podcast without any knowledge of audio editing, video, or production. You do the talking, and the AI handles the production, editing, clipping, and the rest, and you can direct your AI producer in plain English. You can even record from your phone, so no expensive studio gear is needed to sound great. ZenAI is a new product from Zencastr, a platform I've been a paying customer of for over nine years here at That Triathlon Show. ZenAI is currently in invite-only beta. Join the waitlist today here.LEARN MORE ABOUT SCIENTIFIC TRIATHLON: The Scientific Triathlon website is the home of That Triathlon Show and everything else that we doContact us through our contact form or email me directly (note - email/contact form messages get responded to much more quickly than Instagram DMs)Subscribe to our NewsletterFollow us on InstagramLearn more about our coaching, training plans, and training camps. We have something to offer for everybody from beginners to professionals.HOW CAN I SUPPORT THAT TRIATHLON SHOW (FOR FREE)? I really appreciate you reading this and considering helping the show! If you love the show and want to support it to help ensure it sticks around, there are a few very simple things you can do, at no cost other than a minute of your time. 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For more on this Donal Moriarty, Chief Corporate Affairs Officer at Aer Lingus and Hazel Nolan, National Secretary of Fórsa.
The Federal government just proposed turning grizzly bear management over to Wyoming, Montana, and Idaho--without delisting. How is this possible? The guys discuss the proposed rule, and some of the history of the past 15 years that led to the proposal (Dave takes WAY too much credit!). Next, they discuss the recent Executive Order that shrinks the boundaries of Bears Ears and Grand Staircase-Escalante National Monuments in southern Utah. They explain a little of the history, the pendulum swings, and why it's time to start thinking about durability, not dogma. Finally, they give a quick update on a rule that changes the definition of "harm" under the Endangered Species Act. Lots of meat in this episode. Want to share ideas, complain, praise, or just engage in a conversation. Reach out at our new email address yourmountainpodcast@gmail.com, or find us on Instagram or Facebook: @itsyourmountain.
4:20 pm: Nic Dunn, Senior Fellow and V.P. of Strategy for the Sutherland Institute, joins the program to discuss his piece about using empowerment accounts as a streamlined system to fight poverty.4:38 pm: Garfield County Commissioner Leland Pollock joins the show for a conversation about President Trump's expected reduction of the Bears Ears and Grand Staircase-Escalante National Monuments.6:20 pm: Peter Laffin, Senior Editor for the Washington Examiner, joins the show to discuss his piece about how President Trump needs to reset the conversation about Iran, beginning with American citizens.
The data shows a total of 4.2 million tonnes of was handled in 2025, down from close to 4.4 million tonnes the year before.
Amy MacIver speaks to Carl Lindemann | Outreach Coordinator, Astronomical Society of Southern Africa (ASSA) Cape Centre; Former Dark Sky Officer about why darkness is good for the environment and the go-to spots in Cape Town to experience true and uninterrupted darkness. Presenter John Maytham is an actor and author-turned-talk radio veteran and seasoned journalist. His show serves a round-up of local and international news coupled with the latest in business, sport, traffic and weather. The host’s eclectic interests mean the program often surprises the audience with intriguing book reviews and inspiring interviews profiling artists. A daily highlight is Rapid Fire, just after 5:30pm. CapeTalk fans call in, to stump the presenter with their general knowledge questions. Another firm favourite is the humorous Thursday crossing with award-winning journalist Rebecca Davis, called “Plan B”. Thank you for listening to a podcast from Afternoon Drive with John Maytham Listen live on Primedia+ weekdays from 15:00 and 18:00 (SA Time) to Afternoon Drive with John Maytham broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show go to https://buff.ly/BSFy4Cn or find all the catch-up podcasts here https://buff.ly/n8nWt4x Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media: CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.
OA1276 - Who could have predicted this? Us! The Trump administration has made their complete disdain for people with disabilities clear since day one. We've called it out before, and the natural progression of those efforts came to a head mid-June when they announced their intention to turn over governance of special education to RFK Jr in HHS (least trusted man in America when it comes to the needs of your child with a disability), continue dismantling the Department of Education overall, further reduce their investigations of educational discrimination, and, just two days later, their commitment to overturning major protections against forced institutionalization. What's happening, how did we get here, why does it matter, and what can anyone do about it? Tune in to find out. OA episode callbacks: 1238 Deep dive on Olmstead 1180 the history of forced institutionalization and “ugly laws”, and the executive order “Ending crime and disorder on America's streets” 1141 The Section 504 protests 1171 A.J.T. v Osseo area schools (rights to accommodations for students with disabilities) Part 1; attempted dismantling of Olmstead: Olmstead v. L.C. ex rel. Zimring, 527 U.S. 581 (1999) 28 C.F.R. § 35.130(d) Exec. Order No. 14321, 90 Fed. Reg. 35817 (Jul 24, 2025) Application of the Rehabilitation Act and Americans with Disabilities Act to State Institutionalization of Patients with Severe Mental Illness or Disabilities, 50 Op. O.L.C. __ (June 18, 2026) Part 2; the dismantling of the Department of Education: Exec. Order No. 14242, 90 Fed. Reg. 13679 (Mar. 20, 2025) Compl., State of New York v. McMahon, No. 1:25-cv-10601 (D. Mass. amended 01/09/2026) McMahon v. New York, 606 U.S. ___ (2025) Interagency Agreement Between the U.S. Department of Education and U.S. Department of Labor Relating to the Office of Elementary and Secondary Education (OESE) (plus addendums) Christy Wolfe (Dec. 16, 2025), Transferring K-12 Programs to Labor: Why Costs and Logistics Could Be a Problem for States and Schools, Bipartisan Policy Center Jennifer Smith Richards & Jodi S. Cohen (Mar. 2, 2026), ProPublica Sues Education Department for Withholding Records About Discrimination in Schools, ProPublica. U.S. Government Accountability Office (Feb. 2, 2026), Department of Education: Full Costs and Savings Estimate Needed for Reduction-in-Force and Restructuring of the Office for Civil Rights. U.S. Dept. of Education (June 16, 2026). U.S. Department of Education Announces Additional Partnerships to Strengthen Coordination for Individuals with Disabilities Programs, Bolster Civil Rights Enforcement. A.J.T. v. Osseo Area Schools, Independent School Dist. No. 279, 605 U.S. 335 (2025) Section 504 of the Rehabilitation Act of 1973: 29 U.S.C. § 794 Individuals with Disabilities Education Act: 20 U.S.C. § 1400-1409 Check out the OA Linktree for all the places to go and things to do!
Ebook: https://drive.google.com/file/d/1AUsxg05dXkKFeAa64kC0u16XynnSx68o/view?usp=drive_link Episode Description: Every peptide conversation right now is about GLP-1 drugs, BPC-157, and TB-500. Nobody is talking about the one with 50 years of published research that your body is already making and losing as you age. GHK-Cu is a naturally occurring tripeptide that declines by 60% between the ages of 20 and 60. That decline tracks directly with the loss of skin elasticity, slower wound healing, thinning hair, reduced collagen production, and rising inflammation. In randomized controlled trials it has outperformed Rogaine for hair growth, shown a 55% reduction in visible wrinkles, and been documented to positively affect the expression of over 4,000 human genes. Dr. G calls it his favorite peptide, and his partner uses it on her face every day. In this episode, you will learn: • How GHK-Cu works as a copper delivery vehicle at the cellular level, why it modulates gene expression across 31% of the human genome, and what that means for tissue repair, inflammation, and biological aging • The head to head randomized controlled trial where GHK-Cu outperformed minoxidil for hair count, follicle size, and the active growth phase of the hair cycle • Exactly what to look for when buying GHK-Cu cream, why the peptide is chemically fragile, what packaging and pH range to require, and the red flags that tell you to walk away from a product Timestamps: 0:00 - Intro 1:44 - What GHK-CU Actually Is and How It Was First Discovered in 1973 3:10 - Why a 60% Decline in GHK-CU Between Ages 20 and 60 Tracks Directly With Aging 4:40 - What Makes GHK-CU Different From Every Other Popular Peptide 6:00 - How It Stimulates Collagen, Elastin & the Extracellular Matrix 7:15 - The Human Trial Showing a 51% Increase in Collagen Density From Topical Application 8:00 - The 4,000 Genes GHK-CU Affects (And What the Broad Institute Found) 9:30 - Anti-Inflammatory Effects: Why This Matters for Biological Aging 10:30 - Wound Healing, Angiogenesis & Tissue Repair Across Skin, Bone, Gut and Liver 11:30 - The 2022 RCT: 55.7% Reduction in Visible Wrinkles After 12 Weeks 12:30 - Hair Growth: Outperforming Minoxidil in a Head-to-Head Randomized Trial 14:30 - Why the Lower Dose (50mg/ml) Outperformed the Higher Dose 15:30 - Safety Profile, Contraindications & the "Copper Uglies" Explained 17:00 - How to Buy GHK-CU: Concentration, Packaging, pH & What to Avoid Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3448: Kylee shares practical strategies that helped her reduce drinking, from surrounding herself with supportive people and sober-curious communities to building a lifestyle filled with meaningful, alcohol-free activities. She also explores how investing in personal flourishing through relationships, purpose, health, and fulfillment can make alcohol far less appealing, offering an encouraging roadmap for anyone looking to change their relationship with drinking. Read along with the original article(s) here: https://www.ablueskymind.com/blog/how-to-cut-back-on-drinking-tips Quotes to ponder: "Everything we can do drunk we can also do sober, and that we don't have fun because of alcohol, we have fun because of what we are doing and who we are with." "Know the difference between things that might not be great for you, and things that take you down and keep you stuck and bring out your worst and get in the way of your best life." "A big part of the journey I'm on now is retraining myself to fully believe that I can have a rich and whole life without “going out” culture." Episode references: Gallup Alcohol Consumption Survey: https://news.gallup.com/poll/467507/percentage-americans-drink-alcohol.aspx Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3448: Kylee shares practical strategies that helped her reduce drinking, from surrounding herself with supportive people and sober-curious communities to building a lifestyle filled with meaningful, alcohol-free activities. She also explores how investing in personal flourishing through relationships, purpose, health, and fulfillment can make alcohol far less appealing, offering an encouraging roadmap for anyone looking to change their relationship with drinking. Read along with the original article(s) here: https://www.ablueskymind.com/blog/how-to-cut-back-on-drinking-tips Quotes to ponder: "Everything we can do drunk we can also do sober, and that we don't have fun because of alcohol, we have fun because of what we are doing and who we are with." "Know the difference between things that might not be great for you, and things that take you down and keep you stuck and bring out your worst and get in the way of your best life." "A big part of the journey I'm on now is retraining myself to fully believe that I can have a rich and whole life without “going out” culture." Episode references: Gallup Alcohol Consumption Survey: https://news.gallup.com/poll/467507/percentage-americans-drink-alcohol.aspx Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3447: Kylee shares the intentional mindset shifts, tracking strategies, and belief-changing tools that helped her dramatically reduce her alcohol consumption after years of normalizing unhealthy drinking habits. By examining personal assumptions about alcohol, benchmarking drinking patterns, and surrounding herself with supportive people, she offers a practical framework for anyone looking to build a healthier relationship with drinking. Read along with the original article(s) here: https://www.ablueskymind.com/blog/how-to-cut-back-on-drinking-tips Quotes to ponder: "Regretting how much you drank or your decisions around drinking might be “normal” in some social circles, but it is never “healthy.”" "One of my big breakthroughs is that I associate drinking with a “fun” and “rich” life, one that makes me happy, interesting, and likable." "Building awareness is a powerful tool for behavior change, and using a "drink counter" app or practice is a great place to start when it comes to drinking." Episode references: Quit Like a Woman: https://www.amazon.com/Quit-Like-Woman-Radical-Obsession/dp/1984825054 Reframe: https://www.joinreframeapp.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3447: Kylee shares the intentional mindset shifts, tracking strategies, and belief-changing tools that helped her dramatically reduce her alcohol consumption after years of normalizing unhealthy drinking habits. By examining personal assumptions about alcohol, benchmarking drinking patterns, and surrounding herself with supportive people, she offers a practical framework for anyone looking to build a healthier relationship with drinking. Read along with the original article(s) here: https://www.ablueskymind.com/blog/how-to-cut-back-on-drinking-tips Quotes to ponder: "Regretting how much you drank or your decisions around drinking might be “normal” in some social circles, but it is never “healthy.”" "One of my big breakthroughs is that I associate drinking with a “fun” and “rich” life, one that makes me happy, interesting, and likable." "Building awareness is a powerful tool for behavior change, and using a "drink counter" app or practice is a great place to start when it comes to drinking." Episode references: Quit Like a Woman: https://www.amazon.com/Quit-Like-Woman-Radical-Obsession/dp/1984825054 Reframe: https://www.joinreframeapp.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
“I may be the expert in cancer, but you are the expert in you.”—Elisa Port, MDGround Truths is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Dr. Elisa Port is Professor of Surgery, Icahn School of Medicine at Mount Sinai; Chief of Breast Surgery for the Mount Sinai Health System; Director of the Dubin Breast Center; and Director of the Center of Excellence for Breast Cancer at the Mount Sinai Tisch Cancer Center, a NCI-Designated Comprehensive Cancer Center. She is remarkably well qualified to provide guidance for prevention and treatment of breast cancer, and runs a model program at Mount Sinai in New York (←we'll get into why I say that).She has just published a terrific book that centers around the concept of informed optimism. Many of her patient stories are integrated.We tried to cover the waterfront during our conversation including:—4 Ws for reduction of risk: weight, walking, wine, and working out (especially in Nature, “green exercise”)—Only 10-12% of women will ever develop breast cancer during their lives —Role of adipocytes (fat cells), aka estrogen and inflammation factories—Misinformation (underlying the need for this book)—Pervasive myths of magic supplements, with safety issues of unregulated intravenous drips and others when analyzed turned out to be crushed up, dried house plants—Total body MRI: mixed results from her patients —Breast cancer on the rise in young women. Dr. Port relates about recent patients diagnosed in their 20s. Some without BRCA or other pathogenic mutation. Why?—Mammograms in non-dense breasts pick up 80-90% of breast cancer. It's the 40-50% women with dense breasts, which the scan is trying to find a polar bear in a snowstorm, is a problem. The problem with false-positives.—Use of AI with mammography for increased initial detection, prevention, detect high-risk in women with a “normal” mammogram, and risk of heart disease (see my recent Ground Truths and piece in The Lancet on this important topic)—Mount Sinai provides Transpara AI (the one validated by the big Sweden trial of >100,000 women) to all women getting mammograms FOR FREE. That is the best validated AI tool in medicine today!—How a mammogram saved a patient's life, not about breast cancer!—Hormone replacement and birth control pills. How to assess benefit and risk in women young and older? Differences in the hormone risks.—Tamoxifen for primary prevention in high-risk people. Reduction of breast cancer in 50% or more in these women. In some subgroups reduction as high as 80%!—GLP-1 drugs may reduce breast cancer risk and this may not just be related to weight loss—Lack of utilization of Genetic testing (it could be your father). I disagreed with respect to use of polygenic risk scores, as I wrote about in SUPER AGERS—“I just wanted to scream out on top of the mountain about genetic testing, family history, and early screening.” Tennis legend Chris Evert—The lack of our ability to assess the immune system in the clinic and how that could change the face of prevention and very early detection of breast cancerAn infographic summary I made on Dr. Port's book with the help of NotebookLM****************************************Thank you YOUR DOCTOR KLOVER, Diane Romero, Bob Fleischman, Danielle, MagnaAnimus, and 450+ others for tuning into my live video with Elisa Port! Join me for my next live video in the app.A big thanks to all the Ground Truths subscribers from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. If you're not a subscriber, please join!If you found this interesting PLEASE share it!Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support a record number of 51 summer interns coming in 2026! These are high school, college and medical students selected from thousands of applicants. We couldn't do this expanded program without the funds coming in through Ground Truths. Get full access to Ground Truths at erictopol.substack.com/subscribe
This podcast shows you how to fully recover from OCD.Each episode breaks down the exact techniques and nuances that stop rumination, reduce compulsions, and help you retrain your brain out of the OCD cycle. We cover every major OCD theme, including:Pure-O OCDRelationship OCDHarm OCDReal Event OCDSO-OCD / Sexuality OCDReligious / Scrupulosity OCDCleaning & Contamination OCDPhysical CompulsionsAll other OCD subtypesMy goal is simple: clear guidance that actually works, explained in a way that is calm, direct, and easy to apply immediately.You can fully recover from OCD. Don't give up — you're not stuck, and your brain can change.
The Education Department's Office of the Chief Information Officer lost more than half of its staff in early 2025 during the Trump administration's reduction-in-force campaign, leaving some suboffices completely empty, the agency's Office of the Inspector General found in a report issued Monday. The OIG used Microsoft Office and Teams to track down who was subject to the RIF during the first nearly ten weeks of President Donald Trump's second term, finding it gutted 40% or 1,579 of the agency's workers in total. The OIG said it was presented with a scope limitation for the review due to the department not providing all requested information or giving unfettered access to Department staff, which limited its ability to fully address the review objective. Specifically in the CIO's office, the OIG counted 44 remaining employees of the 92 employed in January 2025 — a 52% reduction. About 8% of all separated employees in the agency were in IT management, it found, and about $6 million in OCIO contracts were terminated as part of the Department of Government Efficiency's massive agency reorganization campaign in early 2025. Suboffices within the OCIO that are statutorily required to oversee all departmental operational enterprise IT infrastructures and software, develop IT investment performance measures and conduct security reviews mandated by the Federal Information Security Modernization Act have no remaining employees, the report said. NASA issued a long-awaited list of awardees for the latest iteration of a multibillion-dollar cross-government IT acquisition vehicle, moving the large-scale contract forward. In a brief notice on Monday, the agency said it would start processing the awards for the sixth generation of its Solutions for Enterprise‑wide Procurement contract, known as SEWP VI. It also disclosed more than 2,100 awardees across three categories: IT solutions, enterprise-wide IT services, and mission-based IT services. Among the hundreds of awardees, the list includes IBM, Leidos, KPMG, Carahsoft Technology Corp., Peraton, REI Systems, Science Applications International Corporation (SAIC), CACI, Cherokee Nation Government Solutions, Amivero and Guidehouse. All of the awards are indefinite-delivery, indefinite-quantity, with a 10-year ordering period and a maximum ordering value of $20 billion. The contract period begins Nov. 1 and will run through October 2036. The Daily Scoop Podcast is available every Monday-Friday afternoon. If you want to hear more of the latest from Washington, subscribe to The Daily Scoop Podcast on Apple Podcasts, Soundcloud, Spotify and YouTube.
WBBM political editor Geoff Buchholz reports on Chicago Mayor Brandon Johnson's new executive order creating a dedicated Office of Gun Violence Reduction.
WBBM political editor Geoff Buchholz reports on Chicago Mayor Brandon Johnson's new executive order creating a dedicated Office of Gun Violence Reduction.
WBBM political editor Geoff Buchholz reports on Chicago Mayor Brandon Johnson's new executive order creating a dedicated Office of Gun Violence Reduction.
PainExam Podcast Show Notes NAD+ Supplementation in Pain and Inflammation: Hype, Hope, or Emerging Science? Hosted by: PainExam Podcast Presented by: NRAP Academy (Neuromodulation, Regional Anesthesia & Pain) Host: David Rosenblum, MD Episode Overview In this episode of the PainExam Podcast, we explore the growing interest in NAD+ (Nicotinamide Adenine Dinucleotide) supplementation and its potential role in pain management, inflammation reduction, cellular recovery, and healthy aging. NAD+ is a naturally occurring coenzyme found in every living cell and is essential for energy production, mitochondrial function, DNA repair, and cellular resilience. As NAD+ levels decline with age, chronic stress, inflammation, and disease, researchers have begun investigating whether restoring NAD+ levels may improve outcomes in chronic pain conditions and inflammatory disorders. We review the current science, discuss potential mechanisms of action, and examine how NAD+ therapy is being integrated into regenerative medicine, wellness programs, and pain management practices. What is NAD+? NAD+ is a coenzyme involved in: ✅ Cellular energy production (ATP generation) ✅ Mitochondrial health ✅ DNA repair pathways ✅ Oxidative stress reduction ✅ Neuroprotection ✅ Cellular signaling ✅ Activation of longevity-associated proteins called sirtuins Without adequate NAD+, cells become less efficient at producing energy and managing inflammation. Why Might NAD+ Matter in Chronic Pain? Many chronic pain conditions involve: Mitochondrial dysfunction Oxidative stress Neuroinflammation Peripheral and central sensitization Impaired cellular recovery Researchers hypothesize that optimizing NAD+ levels may help address several of these pathways simultaneously. Potential areas of interest include: Neuropathic Pain NAD+ may support: Nerve repair Axonal recovery Mitochondrial function within neurons Reduction of oxidative injury Inflammatory Pain NAD+ influences inflammatory signaling pathways and may help modulate: Cytokine production Immune cell activity Cellular stress responses Fatigue and Recovery Patients with chronic pain frequently report: Fatigue Brain fog Reduced exercise tolerance Poor recovery Because NAD+ plays a critical role in energy metabolism, some clinicians report improvements in energy and recovery following supplementation. Potential Mechanisms of Action 1. Improved Mitochondrial Function Mitochondria generate ATP, the body's energy currency. Reduced NAD+ levels are associated with: Cellular aging Impaired energy production Increased inflammation Supplementation may help restore mitochondrial efficiency. 2. Activation of Sirtuins Sirtuins are proteins involved in: Cellular repair Longevity Metabolic regulation Inflammation control NAD+ serves as a critical substrate for sirtuin activity. 3. DNA Repair Support NAD+ is required for enzymes known as PARPs (Poly ADP Ribose Polymerases), which participate in DNA repair processes following cellular injury. 4. Reduction of Oxidative Stress Chronic inflammation often produces excessive reactive oxygen species (ROS). NAD+ may help maintain cellular antioxidant defenses and reduce oxidative injury. Routes of NAD+ Supplementation Intravenous (IV) NAD+ Most commonly marketed in wellness and recovery clinics. Potential advantages: Direct systemic delivery Avoids gastrointestinal absorption issues Allows higher dosing protocols Potential limitations: Cost Time commitment Variable evidence base Oral Precursors Rather than NAD+ itself, many supplements provide precursors such as: Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) These compounds are converted into NAD+ within the body. What Does the Evidence Show? Current evidence remains preliminary. While preclinical and mechanistic studies are promising, large-scale randomized controlled trials evaluating NAD+ specifically for chronic pain are still limited. Areas under active investigation include: Neuropathic pain Neurodegenerative disorders Chronic fatigue syndromes Recovery optimization Healthy aging Patients should understand that NAD+ therapy remains an emerging treatment rather than a standard evidence-based pain intervention. Safety Considerations Reported side effects may include: Nausea Flushing Chest tightness during rapid infusions Headache Fatigue Lightheadedness Most adverse effects appear infusion-rate dependent and can often be minimized through slower administration protocols. Patients should discuss treatment with a qualified healthcare professional, especially if they have: Cardiovascular disease Active cancer Significant medical comorbidities Clinical Pearls for Pain Physicians ✔ Consider NAD+ as a potential adjunct—not a replacement—for evidence-based pain care. ✔ Continue emphasizing exercise, sleep optimization, nutrition, behavioral health, and appropriate interventional therapies. ✔ Discuss realistic expectations with patients. ✔ Recognize that evidence continues to evolve. ✔ Focus on patient-centered outcomes rather than laboratory markers alone. Key Takeaways NAD+ is essential for cellular energy production and repair. Declining NAD+ levels may contribute to aging, inflammation, and chronic disease. Early evidence suggests possible benefits in inflammation, recovery, fatigue, and nerve health. Robust pain-specific clinical trials remain limited. NAD+ therapy should currently be viewed as an adjunctive and investigational strategy in pain management. Resources for Physicians Pain Medicine Board Preparation Prepare for the ABA Pain Medicine Boards with:
PainExam Podcast Show Notes NAD+ Supplementation in Pain and Inflammation: Hype, Hope, or Emerging Science? Hosted by: PainExam Podcast Presented by: NRAP Academy (Neuromodulation, Regional Anesthesia & Pain) Host: David Rosenblum, MD Episode Overview In this episode of the PainExam Podcast, we explore the growing interest in NAD+ (Nicotinamide Adenine Dinucleotide) supplementation and its potential role in pain management, inflammation reduction, cellular recovery, and healthy aging. NAD+ is a naturally occurring coenzyme found in every living cell and is essential for energy production, mitochondrial function, DNA repair, and cellular resilience. As NAD+ levels decline with age, chronic stress, inflammation, and disease, researchers have begun investigating whether restoring NAD+ levels may improve outcomes in chronic pain conditions and inflammatory disorders. We review the current science, discuss potential mechanisms of action, and examine how NAD+ therapy is being integrated into regenerative medicine, wellness programs, and pain management practices. What is NAD+? NAD+ is a coenzyme involved in: ✅ Cellular energy production (ATP generation) ✅ Mitochondrial health ✅ DNA repair pathways ✅ Oxidative stress reduction ✅ Neuroprotection ✅ Cellular signaling ✅ Activation of longevity-associated proteins called sirtuins Without adequate NAD+, cells become less efficient at producing energy and managing inflammation. Why Might NAD+ Matter in Chronic Pain? Many chronic pain conditions involve: Mitochondrial dysfunction Oxidative stress Neuroinflammation Peripheral and central sensitization Impaired cellular recovery Researchers hypothesize that optimizing NAD+ levels may help address several of these pathways simultaneously. Potential areas of interest include: Neuropathic Pain NAD+ may support: Nerve repair Axonal recovery Mitochondrial function within neurons Reduction of oxidative injury Inflammatory Pain NAD+ influences inflammatory signaling pathways and may help modulate: Cytokine production Immune cell activity Cellular stress responses Fatigue and Recovery Patients with chronic pain frequently report: Fatigue Brain fog Reduced exercise tolerance Poor recovery Because NAD+ plays a critical role in energy metabolism, some clinicians report improvements in energy and recovery following supplementation. Potential Mechanisms of Action 1. Improved Mitochondrial Function Mitochondria generate ATP, the body's energy currency. Reduced NAD+ levels are associated with: Cellular aging Impaired energy production Increased inflammation Supplementation may help restore mitochondrial efficiency. 2. Activation of Sirtuins Sirtuins are proteins involved in: Cellular repair Longevity Metabolic regulation Inflammation control NAD+ serves as a critical substrate for sirtuin activity. 3. DNA Repair Support NAD+ is required for enzymes known as PARPs (Poly ADP Ribose Polymerases), which participate in DNA repair processes following cellular injury. 4. Reduction of Oxidative Stress Chronic inflammation often produces excessive reactive oxygen species (ROS). NAD+ may help maintain cellular antioxidant defenses and reduce oxidative injury. Routes of NAD+ Supplementation Intravenous (IV) NAD+ Most commonly marketed in wellness and recovery clinics. Potential advantages: Direct systemic delivery Avoids gastrointestinal absorption issues Allows higher dosing protocols Potential limitations: Cost Time commitment Variable evidence base Oral Precursors Rather than NAD+ itself, many supplements provide precursors such as: Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) These compounds are converted into NAD+ within the body. What Does the Evidence Show? Current evidence remains preliminary. While preclinical and mechanistic studies are promising, large-scale randomized controlled trials evaluating NAD+ specifically for chronic pain are still limited. Areas under active investigation include: Neuropathic pain Neurodegenerative disorders Chronic fatigue syndromes Recovery optimization Healthy aging Patients should understand that NAD+ therapy remains an emerging treatment rather than a standard evidence-based pain intervention. Safety Considerations Reported side effects may include: Nausea Flushing Chest tightness during rapid infusions Headache Fatigue Lightheadedness Most adverse effects appear infusion-rate dependent and can often be minimized through slower administration protocols. Patients should discuss treatment with a qualified healthcare professional, especially if they have: Cardiovascular disease Active cancer Significant medical comorbidities Clinical Pearls for Pain Physicians ✔ Consider NAD+ as a potential adjunct—not a replacement—for evidence-based pain care. ✔ Continue emphasizing exercise, sleep optimization, nutrition, behavioral health, and appropriate interventional therapies. ✔ Discuss realistic expectations with patients. ✔ Recognize that evidence continues to evolve. ✔ Focus on patient-centered outcomes rather than laboratory markers alone. Key Takeaways NAD+ is essential for cellular energy production and repair. Declining NAD+ levels may contribute to aging, inflammation, and chronic disease. Early evidence suggests possible benefits in inflammation, recovery, fatigue, and nerve health. Robust pain-specific clinical trials remain limited. NAD+ therapy should currently be viewed as an adjunctive and investigational strategy in pain management. Resources for Physicians Pain Medicine Board Preparation Prepare for the ABA Pain Medicine Boards with:
PainExam Podcast Show Notes NAD+ Supplementation in Pain and Inflammation: Hype, Hope, or Emerging Science? Hosted by: PainExam Podcast Presented by: NRAP Academy (Neuromodulation, Regional Anesthesia & Pain) Host: David Rosenblum, MD Episode Overview In this episode of the PainExam Podcast, we explore the growing interest in NAD+ (Nicotinamide Adenine Dinucleotide) supplementation and its potential role in pain management, inflammation reduction, cellular recovery, and healthy aging. NAD+ is a naturally occurring coenzyme found in every living cell and is essential for energy production, mitochondrial function, DNA repair, and cellular resilience. As NAD+ levels decline with age, chronic stress, inflammation, and disease, researchers have begun investigating whether restoring NAD+ levels may improve outcomes in chronic pain conditions and inflammatory disorders. We review the current science, discuss potential mechanisms of action, and examine how NAD+ therapy is being integrated into regenerative medicine, wellness programs, and pain management practices. What is NAD+? NAD+ is a coenzyme involved in: ✅ Cellular energy production (ATP generation) ✅ Mitochondrial health ✅ DNA repair pathways ✅ Oxidative stress reduction ✅ Neuroprotection ✅ Cellular signaling ✅ Activation of longevity-associated proteins called sirtuins Without adequate NAD+, cells become less efficient at producing energy and managing inflammation. Why Might NAD+ Matter in Chronic Pain? Many chronic pain conditions involve: Mitochondrial dysfunction Oxidative stress Neuroinflammation Peripheral and central sensitization Impaired cellular recovery Researchers hypothesize that optimizing NAD+ levels may help address several of these pathways simultaneously. Potential areas of interest include: Neuropathic Pain NAD+ may support: Nerve repair Axonal recovery Mitochondrial function within neurons Reduction of oxidative injury Inflammatory Pain NAD+ influences inflammatory signaling pathways and may help modulate: Cytokine production Immune cell activity Cellular stress responses Fatigue and Recovery Patients with chronic pain frequently report: Fatigue Brain fog Reduced exercise tolerance Poor recovery Because NAD+ plays a critical role in energy metabolism, some clinicians report improvements in energy and recovery following supplementation. Potential Mechanisms of Action 1. Improved Mitochondrial Function Mitochondria generate ATP, the body's energy currency. Reduced NAD+ levels are associated with: Cellular aging Impaired energy production Increased inflammation Supplementation may help restore mitochondrial efficiency. 2. Activation of Sirtuins Sirtuins are proteins involved in: Cellular repair Longevity Metabolic regulation Inflammation control NAD+ serves as a critical substrate for sirtuin activity. 3. DNA Repair Support NAD+ is required for enzymes known as PARPs (Poly ADP Ribose Polymerases), which participate in DNA repair processes following cellular injury. 4. Reduction of Oxidative Stress Chronic inflammation often produces excessive reactive oxygen species (ROS). NAD+ may help maintain cellular antioxidant defenses and reduce oxidative injury. Routes of NAD+ Supplementation Intravenous (IV) NAD+ Most commonly marketed in wellness and recovery clinics. Potential advantages: Direct systemic delivery Avoids gastrointestinal absorption issues Allows higher dosing protocols Potential limitations: Cost Time commitment Variable evidence base Oral Precursors Rather than NAD+ itself, many supplements provide precursors such as: Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) These compounds are converted into NAD+ within the body. What Does the Evidence Show? Current evidence remains preliminary. While preclinical and mechanistic studies are promising, large-scale randomized controlled trials evaluating NAD+ specifically for chronic pain are still limited. Areas under active investigation include: Neuropathic pain Neurodegenerative disorders Chronic fatigue syndromes Recovery optimization Healthy aging Patients should understand that NAD+ therapy remains an emerging treatment rather than a standard evidence-based pain intervention. Safety Considerations Reported side effects may include: Nausea Flushing Chest tightness during rapid infusions Headache Fatigue Lightheadedness Most adverse effects appear infusion-rate dependent and can often be minimized through slower administration protocols. Patients should discuss treatment with a qualified healthcare professional, especially if they have: Cardiovascular disease Active cancer Significant medical comorbidities Clinical Pearls for Pain Physicians ✔ Consider NAD+ as a potential adjunct—not a replacement—for evidence-based pain care. ✔ Continue emphasizing exercise, sleep optimization, nutrition, behavioral health, and appropriate interventional therapies. ✔ Discuss realistic expectations with patients. ✔ Recognize that evidence continues to evolve. ✔ Focus on patient-centered outcomes rather than laboratory markers alone. Key Takeaways NAD+ is essential for cellular energy production and repair. Declining NAD+ levels may contribute to aging, inflammation, and chronic disease. Early evidence suggests possible benefits in inflammation, recovery, fatigue, and nerve health. Robust pain-specific clinical trials remain limited. NAD+ therapy should currently be viewed as an adjunctive and investigational strategy in pain management. Resources for Physicians Pain Medicine Board Preparation Prepare for the ABA Pain Medicine Boards with:
Ella Farlinger is the Co-Founder of trusti. We reflect on the growth... The post Pride Rewind: Sex, Health and Stigma Reduction with Ella Farlinger first appeared on Startup Canada.
Dr Amelia Harry is an experienced Advanced Accredited Practising Dietitian, Accredited Nutritionist, and plastics, diet & human health researcher. In this chat, we discuss the latest publication (in Nature Medicine) that Dr Amelia co-authored on the results of the Plastic Exposure Reduction Transforms Health (PERTH) Trial - which assessed phthalates and bisphenols in humans and what impact a change in diet had. We discuss the methodology, results (it's good news !!) and how you can minimise plastic ingestion in your own life (and why you should).Useful links:Dr Amelia on LinkedIn (here)eatsustainably.com.auJournal paper, Low-plastic diet and urinary levels of plastic-associated phthalates and bisphenols: the randomized controlled PERTH Trial (here) Hosted on Acast. See acast.com/privacy for more information.
Linktree: https://linktr.ee/AnalyticJoin The Normandy For Ad-Free NME, Additional Bonus Audio And Visual Content For All Things Nme+! Join Here: https://ow.ly/msoH50WCu0K In this segment of Notorious Mass Effect, Analytic Dreamz breaks down the latest reports on Bungie's rumored major layoffs in summer 2026 following the official end of Destiny 2's active development.Analytic Dreamz examines claims that up to 50% of Bungie's roughly 800–850 staff could be cut, potentially affecting 400 employees. The discussion covers multiple sources including Sylvain Trinel and Paul Tassi, the $765 million Sony impairment loss, the shift of resources to Marathon, and the timing of expected leadership departures in July 2026 after vesting payouts.This segment also explores Destiny 2's final update Monument of Triumph, the surge in player numbers, the growing Destiny 3 petition nearing 400,000 signatures, Bungie's previous 2024 layoffs, and broader PlayStation studio restructuring. Analytic Dreamz provides context on Sony's 2022 acquisition, Marathon's performance concerns, and what this means for the future of one of gaming's most iconic studios.Essential listening for Destiny fans and industry watchers tracking the latest Bungie and Sony developments. Privacy & Opt-Out: https://redcircle.com/privacy
In this episode of Keeping Abreast, Dr. Jenn Simmons responds to Peter Attia's breast cancer screening episode (#396). Attia asks the right question: why are 42,000 women still dying of breast cancer every year? But his answer, more mammograms and MRI on top, is exactly wrong. Dr. Jenn breaks down, study by study, why that 40-year approach has never moved the death toll.Forty-two thousand women a year. That number has not moved since mammography went mainstream in the 1980s. Detection rates are up, diagnoses are up, and the death toll has not changed. We have been finding more cancer, calling more women patients, and watching the same number of them die. If you have ever scheduled your annual mammogram believing it was the most protective thing you could do, this episode will reframe everything you thought you knew.What You'll LearnWhy the breast cancer death toll has not moved in 40 years, and why more screening is the reasonWhy DCIS is not cancer, why mammography invented it, and what happens to a woman the moment it gets labeled "stage zero"Why an aggressive tumor is aggressive from the day it forms, and why finding it earlier on a mammogram does not change what it does nextWhy mammography catches the cancers least likely to kill you, and routinely misses the ones that willWhat happened when researchers followed 89,835 women for 25 years and compared annual mammography to doing nothing, and why you have never heard about itWhat the Cochrane review found after analyzing every randomized mammography trial ever run, and why Peter Attia addressed it in one sentenceWhy the WISDOM trial, the most significant recent evidence in this space and the one study Attia never mentions, is an indictment of everything he arguedWhy there is no standard radiation dose for a mammogram, and why the woman next to you in the waiting room may have received ten times less than you didWhat the FDA has formally documented about gadolinium staying in the brain and bones for years, and why the women being told to get it every six months are the last women who shouldWhy insulin resistance, chronic inflammation, and toxic burden are among the most powerful drivers of breast cancer risk, and why Attia's episode contained zero mention of any of themResources MentionedPeter Attia, Episode 396 on breast cancer screening: peterattiamd.com/breastcancerscreeningDr. Robin Berzin, founder of Parsley HealthMiller AB, et al. Twenty five year follow-up of the Canadian National Breast Screening Study. BMJ. 2014;348:g366.Gøtzsche PC, Jørgensen KJ. Screening for breast cancer with mammography. Cochrane Database Syst Rev. 2013;(6):CD001877.Zahl PH, et al. Results of the Two-County trial are not compatible with official Swedish breast cancer statistics. Danish Medical Bulletin. 2006;53(4):438–440.Nyström L, et al. Long-term effects of mammography screening: updated overview of the Swedish randomised trials. Lancet. 2002;359:909–19.Esserman LJ, et al. Risk-Based vs Annual Breast Cancer Screening: The WISDOM Randomized Clinical Trial. JAMA. 2026;335(9):763–774.FDA gadolinium-based contrast agent safety communications (2015, 2017, 2018), summarized in Fotenos A, FDA Pediatric Advisory Committee, Sept 2018.Kanda T, et al. High signal intensity in the dentate nucleus and globus pallidus and cumulative gadolinium dose. Radiology. 2014;270(3):834–841.Veenhuizen SGA, et al. Supplemental breast MRI for women with extremely dense breasts: DENSE trial. Radiology. 2021;299(2):278–286.Tabar L, et al. Reduction in mortality from breast cancer after mass screening with mammography. Lancet. 1985;325:829–32.To talk to a member of Dr. Jenn's team and learn more about working privately with Dr. Jenn visit: https://calendly.com/stephanie-1031/clarity-callTo get your copy of Dr. Jenn's book, The Smart Woman's Guide to Breast Cancer, visit: https://tinyurl.com/SmartWomansBreastCancerGuideTo purchase the auria breast cancer screening test go here https://auria.care/ and use the code DRJENN20 for 20% Off.Connect with Dr. Jenn:Website: https://www.jennsimmonsmd.com/Facebook: https://www.facebook.com/DrJennSimmonsInstagram: https://www.instagram.com/drjennsimmons/YouTube: https://www.youtube.com/@dr.jennsimmons
International Bankruptcy, Restructuring, True Crime and Appeals - Court Audio Recording Podcast
After nearly three decades of public service, Shelby shares her experience navigating a Reduction in Force (RIF), the grief that follows career loss, and the challenge of rebuilding professional identity after an unexpected transition.In this candid coaching conversation, Belinda and Shelby explore what it means to process professional grief, move forward without bitterness, and build confidence in the face of uncertainty.They discuss leadership during difficult seasons, the importance of community, and why resilience often begins by remembering the challenges you've already survived.In this episode:Professional grief and career lossLeadership during personal transitionRebuilding confidence after a layoffIdentity shifts and reinventionCoaching, therapy, and resilienceFaith, community, and healingMoving from reflection to actionIf you're navigating a career transition, organizational change, retirement, or an unexpected life pivot, this conversation offers practical wisdom and encouragement for the road ahead.--------------------Our company, Grounded and Global Advisory, is pleased to offer a quarterly advisory retainer. For $275 per month (billed quarterly, with the option to renew each quarter), you'll receive:One 60-minute coaching session per monthPriority access to our calendarOne annual 90-minute strategic intensiveThis offer is for the person who knows what good advisory support feels like and doesn't want to lose it. Spots are limited. If you're interested, email us directly at hello@stirringsuccess.com, and we'll be in touch.Send us a comment!Support the showWe publish new episodes every other Wednesday.Subscribe to the Leadership Tea PodcastSubscribe to Leadership Tea on YouTube!Follow us on Instagram @Leadership_Tea for more inspiration and insights.
How can targeted liver radiation unlock surgical or transplant options for tough hepatocellular carcinoma (HCC) cases? In this episode of BackTable 2026 HCC Creator Weekend™ host Dr. Kavi Krishnasamy is joined by interventional radiologists Dr. Beau Toskich and Dr. Chris Malone to explore how downstaging and radiation lobectomy with Y-90 are creating new surgical and transplant opportunities for patients with limited future liver remnants. They discuss Y-90's role as a “test of time” for tumor biology, strategies to prevent post-hepatectomy liver failure, and the ongoing challenge of recurrence even after R0 resection in cirrhotic livers. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by an educational grant from Sirtex and Boston Scientific. --- Timestamps 00:00 - Introduction01:31 - Rad Lobectomy Goals and Case Discussion06:09 - Selective vs Lobar Dosing07:51 - PVE Versus Y9009:35 - Downstaging to Transplant13:03 - Patient Selection Factors19:22 - Radseg vs. Lobar Strategy22:12 - Percent Liver Treated Debate26:38 - Particle Density and Catheter Bias28:04 - Downstaging Evidence MERIT LT36:20 - Operating After Y9041:25 - Hypertrophy Timing and Readiness43:03 - Wrap Up --- More about this episode The discussion features a case of massive right-lobe HCC in a non-cirrhotic patient, with stepwise Y-90 dosing and selective retreatment leading to complete response and marked liver hypertrophy. The doctors compare radiation lobectomy with portal vein embolization (PVE), explore dosimetry advances from studies like DOSISPHERE and MERITS-LT, and stress the importance of careful mapping and patient selection. Additional topics include the pros and cons of different downstaging methods, functional imaging to assess risk, the impact of lab values and portal hypertension, and the practicalities of timing surgery after Y-90. --- Resources Long-Term Overall Survival After Selective Internal Radiation Therapy for Locally Advanced Hepatocellular Carcinomas: Updated Analysis of DOSISPHERE-01 Trialhttps://jnm.snmjournals.org/content/early/2024/01/10/jnumed.123.266211 Downstaging hepatocellular carcinoma before liver transplantation: A multicenter analysis of the "all-comers" protocol in the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) consortiumhttps://pubmed.ncbi.nlm.nih.gov/37532179/ --- BackTable Vascular & Interventional (VI) is the go-to podcast for interventional radiologists, vascular surgeons, and interventional cardiologists. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app
In this episode of the Essential Wellness Podcast, Aisha Harley and the Oils A to Z panel explored Shinrin Yoku, doTERRA's Japanese Forest Bathing Blend, also known as the "Oil of Immersion." Joined by Will Wan, Dr. Louise Rose, Dr. Mika Carew, and Arianna Harley, the discussion uncovered the blend's physical, emotional, energetic, and Traditional Chinese Medicine benefits. The panel explained how Shinrin Yoku combines powerful botanicals including citrus oils, patchouli, magnolia leaf, Siberian fir, cardamom, cypress, lavandin, and geranium to support nervous system regulation, emotional grounding, and overall wellness. They also explored the science behind forest bathing and shared practical ways to incorporate the blend into daily routines for greater calm, presence, and resilience.
What happens when a split-second accident changes the way you see yourself for more than a decade?In this episode of Plastic Surgery Uncensored, I sit down with Jasmine, a former Navy service member who spent 11 years living with a traumatic lip deformity after a sports injury involving braces. What began as a seemingly routine injury left her with permanent changes to her lip shape, affecting her confidence, smile, photos, and daily interactions for years.Together, we explore a topic rarely discussed in plastic surgery: lip reduction and corrective lip reconstruction. While the world is flooded with information about lip fillers and lip augmentation, very few patients know that surgical solutions exist for traumatic lip deformities, scar tissue, and post-injury asymmetries. In this episode, we discuss:• How lip trauma can permanently alter lip shape• Why many patients struggle for years to find answers• The difference between cosmetic enhancement and reconstructive surgery• The emotional burden of living with a visible facial deformity• Who may be a candidate for lip reduction surgeryJasmine's story is a powerful reminder that even a seemingly small physical concern can have a profound impact on confidence, self-image, and quality of life. And sometimes, the right solution is closer than you think.✨ If you enjoyed this episode of Plastic Surgery Uncensored:✔️ Subscribe on Apple Podcasts, Spotify, or wherever you listen.✔️ Rate & Review—your feedback helps more people find us.✔️ Follow Dr. Rady Rahban across all platforms for daily insights, behind-the-scenes, and patient education:Instagram: @drradyrahbanTikTok: @radyrahbanMDYouTube: @Rady RahbanFacebook: @Rady Rahban✔️ Share this episode with someone considering plastic surgery—the right knowledge can save a life.
DAMIONCarnival Corporation's data breach exposed personal data of nearly 6 million customers: An April social engineering attack on an employee account compromised names, dates of birth, and government-issued ID numbers. WHO DO YOU BLAMESkills: Technology & Cybersecurity: Experience with information technology and cybersecurity matters is increasingly important to mitigate the risks our business faces, promote innovation and maintain a competitive edge in a rapidly evolving technological ageLeast represented 5/11CEO Josh WeinsteinNO: at Carnival since 2002, started as General CounselSir Johathon BandNO: First Sea Lord and Chief of Naval Staff, the most senior officer position in the British Navy (2006 to 2009, when he retired); Admiral and Commander-in-Chief Fleet (2002 to 2006); Served as a naval officer in increasing positions of authority (1967 to 2002)Jason CahillyNO: CEO Dragon Group LLC, provides capital and business management consulting and advisory services worldwide; The NBA: CFO & Chief Strategic Officer; Goldman Sachs: Partner; Global Co-Head of Media and Telecommunications; Head of Principal Investing for Technology, Media & TelecommunicationsNelda ConnorsNO: CEO/Chair Pine Grove Holdings, a privately held investment company; CEO Atkore International, manufacturer of electrical, safety and infrastructure solutions; VP Eaton Corporation, electrical and automotive supplierLaura WeilNO: Founder Village Lane Advisory LLC, specializes in providing executive and strategic consulting services to retailers COO New York & Company, women's apparel and accessories retailer; CEO Ashley Stewart, women's apparel retailer; CEO Urban Brands, apparel retailer; COO AnnTaylor Stores, women's apparel retailer; CFO American Eagle Outfitters, apparel retailerAudit Committee: Oversee management's risk assessment processes to identify principal and emerging risks, including financial, IT, cybersecurity and non-HESS operational risksLaura Weil*: NOJason Cahilly: NOJeffrey Gearhart: NOWalmart Corporate Secretary and lawyerStuart Subotnick: NOCEO at Metromedia Company, wireless/communications, until 2010; Carnival director since 1987 Health, Environmental, Safety and Security Committee: Oversee management's processes to identify principal and emerging health, environmental, safety, security and sustainability-related risks, including those related to ship operations and cybersecurity, RAAS health, environmental, safety, security audits, IAG and external investigations into significant ship incidents, and health, environmental, safety, security-related hotline complaints, and assess the steps management has taken to minimize such risks.Sir Johathon Band*: NONelda Connors: NOHelen Deeble: NOFormer CEO P&O Ferries Division Holdings, shipping and logistics businessKatie Lahey: NOExecutive Chair Korn Ferry Australasia, leadership and talent firmMicky Arison (75%): Exec Chair and former CEO and 7% stockholderThe CEO Pay Ratio1,063:124 retail CEOs made as much in a day as their typical employee earned in a year — and a big one didn't. WHO DO YOU BLAMEThe separation of CEO and Chair: Hamilton E. James Chair/Ron Vachris MMNot uniqueOnly 50% of the board is men. WTF?uniqueOne share = one voteNot uniqueState of HQ = WashingtonAlso StarbucksState of Inc = WashingtonAlso StarbucksPledge of allegiance to stakeholdersCostco generally has: Higher wages; Better benefits; Lower turnover; Higher sales per employee.Industry-leading employee compensation AND Self-imposed low-margin pricing philosophyWalmart only low-margin pricingOther comps:Todd Vasos of Dollar General, Shane O'Kelly of AutoZone, Gerald Morgan of Texas Roadhouse, Jack Sinclair of Sprouts Farmers Market, William Stengel of Genuine Parts Company, Michael Creedon of Dollar Tree, Ronald Sargent of Kroger, Lauren Hobart of Dick's Sporting Goods, Joshua Kobza of Restaurant Brands Inc., Kecia Steelman of Ulta Beauty, Scott Boatwright of Chipotle, Ted Decker of Home Depot, Bob Eddy of BJ's Wholesale Club, Corie Barry of Best Buy, James Conroy of Ross Stores, Chris Turner and David Gibbs of Yum Brands, Chris Kempczinski of McDonald's, Marvin Ellison of Lowe's, Brian Cornell of Target, Ernie Herrman of TJX Companies, Doug McMillon of Walmart, Brian Niccol of Starbucks, Hal Lawton of Tractor Supply Co, Laura Alber of Williams-SonomaFigma Gets an Activist Investor. Exhibit A on Why Companies Don't Want to Go Public. Figma's first year as a public company hasn't gone well. Findell Capital Management said it needs to take steps to shed its unwarranted reputation as an artificial-intelligence “loser.” WHO DO YOU BLAME?Figma founder and CEO Dylan Field: Owns 10% of shares but 72% of voting power: Class B shares worth 15 votes per shareDylan owns 158 Class A Shares (or 0.00003556% of 444,278,887)And Chair$5B net worth$865M total summary compensation in 2025; $91M in 2024Nominating Agreement:Figma must nominate Dylan Field to be a director and include him in the proxy statementThe company must use its resources to back him up and actively convince other shareholders to vote for him In response to a question about how he was going to change the world, Dylan said he was going to build better software for drones.Bro fest sausage party2 of 9 directors are womenTop 5 NEOs all dudesPeter ThielForced Dylan to drop out of Brown for a dumb fellowshipVC Blowhardiness on the BoardVC dude John Lilly (Greylock): Lead Independent Director2nd longest tenure (2014)Member of the Audit Committee; Member of the Nominating Committee (only Lilly and Rimer)VC dude Andrew Reed (Sequoia)Director at debt-maker Klarna Group (also way down since IPO): down roughly 54% from its initial $40.00 IPO price, and down nearly 68% from its all-time highMember of the Compensation Committee (which modeled Dylan's pay package after Elon Musk)VC dude Danny Rimer (Index Ventures)Director since 2014B.A. in History and Literature from HarvardMember of the Compensation Committee (which modeled Dylan's pay package after Elon Musk)Member of the Nominating Committee (only Lilly and Rimer)Luis von AhnDuolingo co-founder and CEO2025: shared an internal email outlining Duolingo's new "AI-first" strategy where Duolingo would “gradually stop using contractors to do work that AI can handle”Stated that "AI is a better teacher than humans" and that the future role of teachers would be reduced to providing "childcare."Blamed the controversy on a "lack of context" in his original statements"AI-First" memo goes viral: $389; today $118MATTDanone, Starbucks shine in methane-reduction rankingDanone is the only company in the group aligned with the Global Methane Pledge, an initiative backed by 150 countries that targets a 30 percent reduction in global levels of the gas by 2030. The French multinational also leads the pack in progress toward its target, having come close to hitting it five years ahead of schedule.WHO DO YOU CREDIT?Chair of the CSR committee Lise Kingo (9% influence), one of three directors tagged as merit directorsmaster's degree in Responsibility & Business from the University of Bathbachelor degrees in Religions and Ancient Greek Artbachelor's degree in Marketing and Economicscertificate as International Director from INSEADEx Novo Nordisk environmental affairs, internal audit, compliance, human resources, communication, branding and sustainabilityHelped create the UN SDGs and the UN Global CompactSomehow only bats 559 on carbon intensity (career) and 415 for scope 1/2 (career)Also, using deference metrics, the ONLY DIRECTOR tagged as fully independentEmployee rep member of the CSR committee Bettina Theissig (5% influence) and the employees of DanoneThe committee charter mandates employees get a say: At least two thirds of the CSR Committee must be independent, as defined by the AFEP-MEDEF Code. At least one Director representing employees must be a member of the Committee.In France (Danone's domicile), the European Investment Bank found that French employees were the most aware of environmental issues - 82% of French employees said they were highly concerned about environmental issues, highest in EuropeLead Independent Director and chair of the Nom/comp committee who put together the comp plan, Valerie Chapoulaud-Floquet15% influence, second to the 18% influence CEO (democracy!!), got 99.16% shareholder approval in April (even as CEO got 89.73% approval and pay got 93.19% approval)20% of short-term pay and 30% of long-term pay is based on hitting sustainability targetsWhen you pay a CEO to do a thing, they are more likely to do a thingEx-CEO Emmanuel FaberOusted in 2021 by the board of directors and activist investors, he transformed Danone into an “enterprise a mission” (a French version of a B corp)Investors voted 99% in favor of the move and a year later ousted Faber, the board resigned, and the new board and CEO are basically moving back towards being environmental leaders because it paid offShort term share price laggedHe said in 2024 that nature is “at the core” of Danone, It took the stock 3 years from Faber's ousting to return to Faber levels - and in the meantime, they were sued for plastics and emissionsIsn't this HIS win?Current CEO Antoine de Saint-AffriqueBecause CEOGM Board Director Jonathan McNeill Stepping DownCEO of DVx Ventures. Ex COO at Lyft Inc. and ex president, Global Sales, Delivery and Service at Tesla, current director at Lululemon, GM director since 2022, on the Governance and Corporate Responsibility committee and Risk and Cybersecurity committee.We know that half of boards on average think someone on the board should be replaced - did the GM board not like McNeill?WHO/WHAT WOULD WE BLAME FOR PUSHING MCNEILL OUT?Outsider dude bro DRLet's be honest, McNeill worked at much more… modern?... companies than GMThe board is OLD SCHOOL - ex Northrop Grumman, ex Visa, ex Lazard, ex HP, ex eBay, ex Novartis, ex Walmart, other directorships at Goldman, Huntsman, P&G… these are professional, insular boardsMeanwhile, he's investing as a VC in AI, other auto/mobility startups, comes from boards that are bro founder lead (Tesla, Lyft) He's invested in AI, crypto, heavy tech, intertwined with VCs all overNot deferential enoughBarra is connected to 94% - THE ENTIRE - boardMcNeill has the highest network power on the board at $9tn, higher than even Mary Barra (who is super connected), but is NOT a power player in the board community of GM - the dominant board communities for GM are massive blue chip US companies, where McNeill has deeper connections in smaller IT/tech focused companiesHe doesn't need the pay, he gets nothing for the connections really, he has connection to Barra but his network is different - was he too independent?Pissed he doesn't have enough influence McNeill has the LOWEST influence on the GM board at 4%He's relatively new, younger, working as a VC where you have a lot of power of capital allocation“I don't need this shit” effect?Too many womenMcNeill's dvX ventures portfolio team is 6 dudes and 1 womendvX entire operations staff is two woman - guess what they do“Chief of Staff” (ie, HR)Executive Assistant (yes, listed on the team)Board is 2 women, 3 men (McNeill not on board)This one seems unlikely I guess?Too busy, meh, move onOne of dvX portfolio companies is curbee, with GM Ventures' Kurt Baumgarten on the board (and the dvX co-founder is founder of Curbee)McNeill on at least 3 of his portfolio boards or advisory committees, plus LULU and GM…
Hour 3 of Scotty G. & The Coach with Scott Garrard and Tim LaComb. Latest on Utah's private equity deal with Otro Capital Final details released on the Myles Garrett trade NEW Guinness World Records title for the most takeaway dishes memorised in 30 seconds
Scotty G. & The Coach with Scott Garrard and Tim LaComb on June 1, 2026. Hour 1 Starting Lineup Party like it's 1999: Spurs vs Knicks NBA Final What You May Have Missed Hour 2 Shehan Jeyarajah, college Football writer for CBS Sports G, B & U: Browns and the Rams finalizing Myles Garrett blockbuster trade Biggest Pet Peeves Hour 3 Latest on Utah's private equity deal with Otro Capital Final details released on the Myles Garrett trade NEW Guinness World Records title for the most takeaway dishes memorised in 30 seconds Hour 4 Spurs-Knicks; Knicks being physical on defense Greg Wyshynski, senior NHL writer for ESPN + MORE
Are you considering a breast reduction or a breast lift but feel completely overwhelmed by all the medical jargon online? In this episode of Big Butts No Lies, Mavi sits down with board-certified New York City plastic surgeon Dr. Keith Blechman to demystify everything you need to know about breast surgery. Dr. Blechman strips away the confusing terminology and breaks down breast anatomy into two simple parts: the skin envelope and the breast mound. We dive into the critical differences between a medically necessary breast reduction (which relieves chronic back pain, neck strain, and bra grooving) and a cosmetic breast lift for deflated or saggy breasts after pregnancy or rapid weight loss. Dr. Blechman also pulls back the curtain on his revolutionary, drain-free recovery protocol and a specialized rib cage nerve block technique that allows over 90% of his patients to recover without any prescription narcotic painkillers. Plus, we explore the step-by-step reality of gender-affirming top surgery, what to realistically expect regarding nipple sensation trade-offs, and how to properly vet your surgeon so you are always in safe hands.⏱️ In this episode:00:00 — Introduction to Dr. Keith Blechman 01:15 — Why I Chose Plastic Surgery 05:07 — The Recovery Diaries Promo05:44 — How to Choose the Right Surgeon 09:26 — The Real Difference: Breast Lift vs. Reduction 14:02 — Is a Breast Reduction Medically Necessary? 16:43 — Let's Talk About Surgical Scars 19:49 — Nipple Sensation & Numbness Risks 23:05 — Can You Breastfeed After a Reduction? 24:21 — Gender-Affirming Top Surgery Explained 28:10 — Crucial Advice for Your Surgery Journey 30:01 — The Drain-Free Recovery Revolution 30:51 — How We Eliminated Prescription Narcotics
Charles Burton examines Canada's controversial economic pivot toward China, where Prime Minister Mark Carney is pursuing a strategic partnership that includes non-public security agreements and the reduction of tariffs on Chinese electric vehicles. Critics warn these moves compromise Canadian sovereignty and allow for significant Chineseinfiltration. (7)1900
If you've been lifting for years and your gains have stalled, there's a hack that recreates the rapid strength gains you had as a beginner, and it works even 15 years into your training career. Sal, Adam, and Justin break down the neuroscience behind newbie gains, share the specific exercises that unlocked a whole new level of growth for each of them, and explain the most common mistake lifters make when trying to apply this (using the new exercise as an accessory instead of making it the priority). Then: a 45% acne reduction from red light therapy in 4 weeks, a chimp civil war in Uganda involving 200 animals that scientists say only happens every 500 years, planned obsolescence in phones and appliances, how Element changed the entire narrative around sodium, and four Instagram Q&As on training while pregnant, switching phases, AI workout programs, and hip imbalances. Sponsors