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Welcome to our final lesson in the Book of Malachi! We explore the myriad questions posed in the book, that feel a bit like a courtroom-like dialogue between God and the Israelites. The timeless nature of Malachi's message resonates across eras by highlighting Israel's pattern of unfaithfulness and connecting it to our own lives. The dense concentration of questions throughout Malachi, up to chapter 3, starkly contrasts with chapter 4 which contains no questions, signaling a shift from inquiry to God's final judgment. Acknowledging God's love, as outlined in Malachi, encourages us to see the ongoing work of God in our lives and the world around us. The Israelites questioned God's love and justice, despised worship practices, and failed to honor God in their daily lives. The answers to the questions in the book of Malachi reveal their shortcomings and guide us towards a faithful relationship with God. The book of Malachi further explores the theme of justice versus grace; as Scripture teaches us, true justice is met only through the grace offered by Jesus. Repentance and confession are essential to understand God's grace. Justice is found through Jesus. The crucial question “How shall we return to You, Lord?” encapsulates the hope of returning to God by recognizing His unchanging nature and engaging with scripture. Stephanie discusses the path to God through spiritual disciplines, offering a free video course, "Pathways to God's Presence,” to deepen this understanding. Make sure to grab your full video course at https://www.gospelspice.com/pathways In the context of the intertestamental period, Malachi's teachings reverberated through four hundred years until John the Baptist's emergence. Stephanie reminds us of historical insights, drawing parallels with significant events and figures like Alexander the Great and the Roman conquest, to contextualize Malachi's message within the fabric of time. Through Malachi 4, God promises ultimate justice and restoration, symbolized by the "sun of righteousness." Here, the imagery of wings is a protective symbol throughout Scripture, which we will compare it to Jesus' teachings. The notion of God's impending judgment is juxtaposed with the promise of protection and healing for those who revere God's name. In the context of the upcoming silence of four hundred years, God's last words offer a solemn warning blended with hope. Through Jesus, who embodied the curse and offered grace, our path was paved for redemption. Malachi invites us to ponder whether we stand beneath the protective wings of the Savior, or risk facing the blazing sun of righteousness without His grace. Malachi today challenges us to live as messengers of faith, rooted in grace through Christ, and eager to spread God's love. DISCOVER THE GOSPEL SPICE MINISTRIES The Gospel Spice Podcast is part of a larger range of tools given to you by Gospel Spice Ministries. In a nutshell, we exist to inspire Christ-followers to delight in God. In more details: we provide resources to empower Christian leaders across generational, social, ethnic and geographical boundaries towards more intimacy with Jesus Christ and discipleship effectiveness through a Biblical Christocentric foundation. The Gospel-Spice Ministries provide a safe environment for spiritual and community growth empowering people to know Christ more intimately, serve one another more powerfully, and reach the world for Jesus. PLAY IT FORWARD by SHARING the link with friends and family. PRAY IT FORWARD by praying for us and those you share it with! PAY IT FORWARD!! Would you consider supporting this show today to help others enjoy it for free? It comes to you completely free, but is labor-intensive to produce, and we want to keep putting it in the ears of people! Gospel Spice Ministries is a non-profit organization registered under the tax-exempt 501c3 status. Your donations are tax-deductible under IRS Section 170. We want to be the best possible stewards of your financial support. All donations above our minimal operating costs go to Christian organizations fighting human trafficking. Go to gospelspice.com for more, and go especially to gospelspice.com/podcast to enjoy our guests! Interested in our blog? Click here: gospelspice.com/blog (*ListenNotes ranking, 2023) You are invited to join us on the Gospel Spice Prayer Bible Study, titled "The heart behind prayer" starting September 20, 2025! Details and registration here: https://www.gospelspice.com/prayer There are a few things in our Christian life that we know we should do more, or at least better – and prayer just might top the list. Prayer is a mystery. Why would a conversation with a human have any influence on God's eternal, sovereign plan? It defies logic, and beckons love. How can God, the Almighty Lord of Hosts, be this close, this personal? It defies understanding, and beckons involvement. But, lack of time, inspiration, and discipline, combined with the ruthless tyranny of our busy lives, push prayer to the periphery, to the “one day I'll get to it” pile. And yet, we can excel at what we endeavor to undertake. So, why isn't prayer more of a spiritual priority? Could we develop a mindset around prayer that made it attractive, inspiring, even maybe delightful? What if we attuned our spiritual ears to listen to God, and our spiritual eyes to see His provision? As an unassuming student, I'm going to humbly offer to share the little I have learned from others about the joy of prayer. I will give us theology, practical tips, and useful resources, sharing what works for me as we, together, learn to pray. If you find prayer intimidating, or if your lack of prayer makes you feel guilty or “less than,” then this is the place for you! If you have been a student of prayer for many years, this is the place for you too! If you have breath in your lungs, then prayer can become one of the deepest joys of your day. Don't miss out! A PERSPECTIVE ABOUT PRAYER To pray is to believe that God not only hears, but that He responds. It is to stand in the gap for a broken world, wielding the authority of Christ, empowered by the Spirit, and trusting in the goodness of the Father. The question is not whether prayer works, but whether we are willing to pray the kinds of prayers that invite God's Kingdom into the darkest places of the earth—and of our own hearts. We may never fully understand the mechanics of prayer, or how it intersects with God's sovereignty, but we are not called to understand everything. We are called to be faithful. And faithfulness means showing up—in prayer, in persistence, in expectation. So today, let us pray not only for the comfort of our hearts, but for the transformation of the world. Let us take our place as image-bearers, co-laborers, and co-heirs. Let us believe that God is still listening—and still acting. Because He is. There's only one way to find out what might happen when we truly pray like this. Let's begin. THE MINDSET BEHIND THIS COURSE Before we begin, let me tell you the obvious: I don't really know how to pray. I'm a humble student and absolute beginner at the holy endeavor that is prayer. So, this course isn't really about what I've learned, or any wisdom I might have gathered. But, I've sat at the feet of many prayer warriors over the decades, through books and teachings. So, I'll share what I learned from them. Humility is going to be our primary heart posture! With each lesson, I will offer a few thoughts, practices, and ideas – with much humility, and not taking myself too seriously. I will also share her favorite books and resources about prayer. FInally, I will introduce you to some of the most influential prayer warriors of our history as the Body of Christ. Most importantly, I will invite YOU to pray! Learning to pray comes from praying. Our humble ambition is to inspire you to pray, and to give you a few tips on how to do that. Then, it's up to you! Prayer is a lifelong endeavor. Let's make it delightful together! So, let's get started. You are invited to join us on the Gospel Spice Prayer Bible Study, titled "The heart behind prayer" starting September 20, 2025! Details and registration here: https://www.gospelspice.com/prayer There are a few things in our Christian life that we know we should do more, or at least better – and prayer just might top the list. Prayer is a mystery. Why would a conversation with a human have any influence on God's eternal, sovereign plan? It defies logic, and beckons love. How can God, the Almighty Lord of Hosts, be this close, this personal? It defies understanding, and beckons involvement. But, lack of time, inspiration, and discipline, combined with the ruthless tyranny of our busy lives, push prayer to the periphery, to the “one day I'll get to it” pile. And yet, we can excel at what we endeavor to undertake. So, why isn't prayer more of a spiritual priority? Could we develop a mindset around prayer that made it attractive, inspiring, even maybe delightful? What if we attuned our spiritual ears to listen to God, and our spiritual eyes to see His provision? As an unassuming student, I'm going to humbly offer to share the little I have learned from others about the joy of prayer. I will give us theology, practical tips, and useful resources, sharing what works for me as we, together, learn to pray. If you find prayer intimidating, or if your lack of prayer makes you feel guilty or “less than,” then this is the place for you! If you have been a student of prayer for many years, this is the place for you too! If you have breath in your lungs, then prayer can become one of the deepest joys of your day. Don't miss out! A PERSPECTIVE ABOUT PRAYER To pray is to believe that God not only hears, but that He responds. It is to stand in the gap for a broken world, wielding the authority of Christ, empowered by the Spirit, and trusting in the goodness of the Father. The question is not whether prayer works, but whether we are willing to pray the kinds of prayers that invite God's Kingdom into the darkest places of the earth—and of our own hearts. We may never fully understand the mechanics of prayer, or how it intersects with God's sovereignty, but we are not called to understand everything. We are called to be faithful. And faithfulness means showing up—in prayer, in persistence, in expectation. So today, let us pray not only for the comfort of our hearts, but for the transformation of the world. Let us take our place as image-bearers, co-laborers, and co-heirs. Let us believe that God is still listening—and still acting. Because He is. There's only one way to find out what might happen when we truly pray like this. Let's begin. THE MINDSET BEHIND THIS COURSE Before we begin, let me tell you the obvious: I don't really know how to pray. I'm a humble student and absolute beginner at the holy endeavor that is prayer. So, this course isn't really about what I've learned, or any wisdom I might have gathered. But, I've sat at the feet of many prayer warriors over the decades, through books and teachings. So, I'll share what I learned from them. Humility is going to be our primary heart posture! With each lesson, I will offer a few thoughts, practices, and ideas – with much humility, and not taking myself too seriously. I will also share her favorite books and resources about prayer. FInally, I will introduce you to some of the most influential prayer warriors of our history as the Body of Christ. Most importantly, I will invite YOU to pray! Learning to pray comes from praying. Our humble ambition is to inspire you to pray, and to give you a few tips on how to do that. Then, it's up to you! Prayer is a lifelong endeavor. Let's make it delightful together! So, let's get started. Support us on Gospel Spice, PayPal and Venmo!
The Social Programme - Pathways to Marriage | The Walima by Radio Islam
With less than a month until IASA's Annual Conference, join us for an inside look at what's in store for attendees. We'll highlight key speakers, dive into the exciting breakout sessions planned, and explore why IASA selected "Pathways to the Future: Innovating for the Next Generation" as this year's conference theme. Whether you're already registered or still deciding, this episode will help you make the most of your conference experience and understand how the event connects to the future of our industry.
The Social Programme - Pathways to Marriage | Prophetic Guidance for a Blissful Marriage by Radio Islam
In this episode, Kristen explores how grief often underlies anxiety, trauma, and panic attacks with Debbie Jenkins Frankel, LMFT, a grief-informed psychotherapist. They share insights and tools for working through unfinished business and moving toward healing. PrivatePracticeGrief.com When you purchase Debi Franle's recommended books through these Amazon affiliate links, you're helping support the podcast at no extra cost to you: 1. Hour of the Heart: Connecting in the Here and Now: https://amzn.to/453Epyx 2. The Gift of Therapy: An Open Letter to a New Generation of Therapists and Their Patients:https://amzn.to/4mlaR5P 3. Superhero Grief (Series in Death, Dying, and Bereavement): https://amzn.to/3IZhMmd Subscribe and get a free 5-day journal at www.kristendboice.com to begin closing the chapter on what doesn't serve you and open the door to the real you. This information is being provided to you for educational and informational purposes only. It is being provided to you to educate you about ideas on stress management and as a self-help tool for your own use. It is not psychotherapy/counseling in any form. This information is to be used at your own risk based on your own judgment. For my full Disclaimer please go to www.kristendboice.com. For counseling services near Indianapolis, IN, visit www.pathwaystohealingcounseling.com. Pathways to Healing Counseling's vision is to provide warm, caring, compassionate and life-changing counseling services and educational programs to individuals, couples and families in order to create learning, healing and growth.
The FDA has granted accelerated approval to semaglutide (Wegovy) as the first drug for metabolic dysfunction–associated steatohepatitis (MASH), showing significant improvements in liver health and weight loss in the phase 3 ESSENCE trial. A systematic review of acetaminophen use in pregnancy found potential risks with long-term or frequent use but confirmed short-term, low-dose use remains appropriate when needed. Finally, an AI model integrating MRI, biomarkers, and clinical data improved prediction of knee osteoarthritis progression, enhancing physician accuracy and suggesting future support for earlier, personalized interventions.
Scaling New Heights Podcast: Cutting Edge Training For Small Business Advisors
On this episode of the Woodard Report podcast, Joe and Heather speak about the latest IRS leadership turnover and the growing shift in CPA licensure requirements, including Illinois' move from the 150-hour to the 120-hour rule. They also share insights on how AI is reshaping opportunities in the profession, discuss the value of niching for accounting firms, and reflect on lessons from pop culture quotes. Referenced during the show: Current events — Billy Long out as IRS commissioner after less than two months Illinois signs new CPA pathways bill TV/Movie quote of the week — Heather mentioned The White Lotus, Season Three Joe mentioned 21 Excellent things we learned — Clients Demand Niche Know-How, and They're Willing to Pay for It Member spotlight — Vicky D Henry, CPA Thrive Business Services The Woodard Report article of the week — Nailing Your Niche: Stop Taking Everyone as a Client Thank you to our show sponsor, Bill, your financial operations platform. Bill is the intelligent way to create and pay bills, send invoices, manage expenses, control budgets and access the credit your business needs to grow all in one platform. Learn more about the show and our sponsors at Woodard.com/podcast
What happens when you're no longer engaging in dangerous eating disorder behaviors, but food still feels like it controls your life? In this episode, Dr. Marianne Miller unpacks the concept of quasi-recovery, a space that can feel both safer than active illness and yet not fully free. Quasi-recovery often includes improved behaviors, such as more regular meals or weight restoration, but leaves behind the deeper work of healing food fear, body shame, and internalized rules. It can be an especially frustrating and lonely experience, because it is often praised by others even when it does not feel like real recovery on the inside. Dr. Marianne explores how quasi-recovery can shape lifelong eating struggles and why people often get stuck there. This episode also considers how neurodivergent and marginalized folks are particularly vulnerable to staying in quasi-recovery when treatment does not address trauma, sensory needs, systemic harm, or body autonomy. This episode covers: What quasi-recovery is and how it shows up in daily life Why healing requires more than just behavior change How fear and food rules quietly persist in this phase Why some people believe they will struggle with food forever What a more liberating vision of recovery can look like If you have ever wondered whether you are truly recovered or just surviving in a different way, this episode offers clarity, compassion, and hope. You do not have to stay stuck in a version of recovery that does not meet your full needs. There is more available to you. CONTENT CAUTION: This episode discusses eating disorder behaviors, body image distress, and systemic oppression. Please take care while listening. RELATED EPISODES ON QUASI-RECOVERY & ORTHOREXIA: Orthorexia, Quasi-Recovery, & Lifelong Eating Disorder Struggles with Dr. Lara Zibarras @drlarazib on Apple & Spotify. Orthorexia Uncovered: Causes, Challenges, & Pathways to Healing on Apple & Spotify. An Orthorexia Recovery Story with Sabrina Magnan, @sabrina.magnan.health on Apple & Spotify. LEARN MORE: Dr. Marianne Miller is a fat, neurodivergent eating disorder therapist and ARFID educator. She supports individuals recovering from ARFID, binge eating disorder, anorexia, bulimia, and quasi-recovery. Her work centers autonomy, sensory attunement, and liberation. It is also neurodivergent-affirming and trauma-informed. She provides Queer-affirming and gender-affirming care. Dr. Marianne is late-diagnosed autistic. For those who connect with this discussion and suspect ARFID may be part of their experience, or for clinicians seeking to better understand this overlap, Dr. Marianne offers her ARFID and Selective Eating Course. This self-paced program provides neurodivergent-affirming strategies and tools to address ARFID, including its intersection with anorexia, in both teens and adults. INTERESTED IN HANGING OUT MORE IN DR. MARIANNE-LAND? Go to my website https://www.drmariannemiller.com Follow me on Instagram @drmariannemiller Look into my self-paced, virtual, anti-diet, subscription-based curriculum. It is called Dr. Marianne-Land's Binge Eating Recovery Membership. Check out my blog. Want more information? Email me at hello@mariannemiller.com
Why doesn't God answer prayer? Why do bad things happen even when I pray? In this message from Pastor Andy Schmeck in the Fierce Pathways series, we dive into the real reasons prayer works (and why sometimes it feels like it doesn't).You'll learn:What we can expect from resurrection life—and why we should pray for a whole, healed life now.Why sin can hinder our prayers—and how God exchanges our broken “report card” for His perfect one.The posture of prayer—confessing, living, and receiving forgiveness so nothing stands in the way of connecting with God.If you've ever wondered why doesn't God answer me? or what's the point of prayer?—this message is for you.
This week on the League of Ireland Women's Podcast, Breifne Earley and Aaron Clarke unpack a busy few days in Irish women's football — from European playoffs to the FAI Cup Semi-Final clash with Leinster Rugby, and a full round of League action with major title implications.
On this episode in our Pathways to PwC Series, we speak with Lea Gray. Lea is a Tax Manager and discusses her journey from graduating with a Liberal Arts degree to excelling in her career at PwC.There's more than one way into a career in accounting — hear how this PwC leader turned unexpected beginnings into lasting impact.
Occupational therapist Heather Billiot joins me to talk about how OT supports children with autism. From sensory integration to daily living skills, Heather shares practical strategies that help kids build independence and confidence. Parents, educators, and professionals will come away with simple, effective tools they can use to support autistic children at home and in the classroom.About HeatherHeather Billiot, MS, OTR/L is a pediatric occupational therapist with over a decade of experience supporting neurodivergent children and their families. Known for her creative, play-based approach, Heather blends evidence-based practice with a deep respect for each child's individuality. She is also a Reiki Master Teacher and shares sensory-friendly ideas and therapeutic insights through her Instagram account @squishy_explores. Whether in clinics, homes, or on the road with her traveling family, Heather is passionate about empowering kids and parents through connection, curiosity, and joy.About TheresaA wife and a mother to two children and grandmother, Theresa Alexander Inman is a Parenting Coach, Board Certified Behavior Analyst, Infant Toddler Development Specialist, Autism Spectrum Disorder Clinical Specialist. Introduced to behavior analysis in 2007 after years in the juvenile justice system.Her goal is to improve the lives of children and families by helping them strategize child develop skills to prevent or reduce the effects of possible delays while having fun! She also served as a panelist on the first annual Autism World Summit.Theresa is also an author, having published “Pathways to Early Communication” in 2022.Connect with Theresa today!• Instagram | Theresa Inman• LinkedIn | Theresa Inman• BabyBoomer.org | Theresa Inman• YouTube | Parenting with Confidence• Tiktok | https://www.tiktok.com/@parentcoachtheresa• Spotify via Anchor.fm | Parenting with Confidence Website: https://www.theresaalexanderinman.com/About Parenting on the SpectrumRaising autistic children comes with unique joys, challenges, and learning moments. Join host Theresa as she explores the diverse experiences of parenting kids on the spectrum. Each episode features expert insights, real-life stories, and practical strategies to help you navigate this journey with understanding, compassion, and strength. Whether you're a parent, caregiver, or ally, this podcast is your go-to resource for fostering connection and celebrating neurodiversity. Please share, comment, rate, and download! Be blissful! Theresa
In a world filled with chaos and stress, sometimes the greatest gift we can give ourselves is healing. Audrey Hope is internationally known as a transformative healer, working with everyone from celebrities and CEOs to lawyers and athletes for over 20 years. She takes a soul-centered approach, guiding people through relationships, addiction, and life's toughest challenges. Just like her name implies, she brings hope — using non-conventional methods as both a psychic and spiritual therapist. Some even call her a ‘sniper' because she has the unique ability to get right to the root of the soul and heal with a single shot. Audrey has been featured on major media. She hosts the YouTube show Hope for Relationships. She's also an addiction therapist at the world-renowned Seasons in Malibu. Her techniques are amazing. Learn more as we tap into her insights in this Women Road Warriors episode with Shelley Johnson and Kathy Tuccaro.@theaudreyhopeAudreyHope.comInstagramYouTubeFacebookhttps://womenroadwarriors.com/ https://womenspowernetwork.net#PsychicTherapy #AudreyHope #TheAudreyHope #Therapy #Transformation #ShelleyJohnson #ShelleyMJohnson #KathyTuccaro #WomenRoadWarriors
Aunties on Air Episode 31: Education & Learning Opportunities: Pathways to Learning, Connecting & ThrivingEducation and opportunities allow for magic and discovery to happen. ALL of the Aunties will be here for this important discussion. For generations, indigenous people have had limited opportunities to find success in the Western world, often creating isolation for indigenous young people. Today, our Aunties are joined by Dr. Sylvia Torti, an award-winning author and the president of College of the Atlantic, which means that all of the voices in today's show will hold a variety of experiences with higher education. Join the ‘Aunties' in the studio as they discuss the journey of accessing academia while utilizing a two-eyed seeing approach always. Wabanaki Words Used:Apc-oc (again in the future, parting, good-bye, farewell) https://pmportal.org/dictionary/apc-oc Topics Discussed:Sylvia Torti - https://en.wikipedia.org/wiki/Sylvia_TortiCherryfield, Maine - https://en.wikipedia.org/wiki/Cherryfield,_MaineCollege of the Atlantic (COA) - https://www.coa.edu/about/Dawnland Festival - https://www.abbemuseum.org/dawnland-festivalAbbe Museum - https://www.abbemuseum.org/The Village Green, Bar Harbor - https://en.wikipedia.org/wiki/Village_Green,_Bar_Harbor3 Sisters Garden, Coastal Maine Botanical Gardens - https://www.facebook.com/reel/1034076295236184Coffee and Conversation, College of the Atlantic - https://coa.swoogo.com/coffeeandconversation2025Corey Hinton - https://dwmlaw.com/profile/michael-corey-f-hinton/Suzanne Greenlaw - https://schoodicinstitute.org/team/suzanne-greenlaw/Ecological Biology - https://en.wikipedia.org/wiki/EcologyChiapas, Mexico - https://en.wikipedia.org/wiki/ChiapasChiapas, Mexico Civil War - https://en.wikipedia.org/wiki/Chiapas_conflictDemocratic Republic of Congo - https://en.wikipedia.org/wiki/Democratic_Republic_of_the_CongoMmbuti people/Pygmy people - https://en.wikipedia.org/wiki/Mbuti_peopleUniversity of Utah - https://www.utah.edu/Peggy Rockefeller Farm - https://www.coa.edu/farms/peggy-rockefeller-farm/Dene Tribe - https://denenation.com/Land Acknowledgement - https://en.wikipedia.org/wiki/Land_acknowledgementCOA Wabanaki full tuition waiver - https://www.coa.edu/admissions/financial-aid/wabanaki-tuition-waiver/Darren Ranco - https://umaine.edu/anthropology/faculty-staff/dr-darren-j-ranco/John Bear Mitchell - https://umaine.edu/nativeamericanprograms/people/john-bear-mitchell/University of Maine - https://umaine.edu/Zapatista Rebelión - https://en.wikipedia.org/wiki/Zapatista_uprisingSylvia Torti, “Cages” - https://www.amazon.com/Cages-Sylvia-Torti/dp/1943156182Sylvia Torti, “The Scorpion's Tail” - https://www.amazon.com/Scorpions-Tail-Sylvia-Torti/dp/1931896178Merlin App - https://merlin.allaboutbirds.org/sound-id/Bar Harbor, Maine - https://www.visitbarharbor.com/MDI - https://acadiamagic.com/mount-desert-island.htmlCarol Wishcamper - https://www.carolwishcamper.com/bio/Criterion Theater - https://www.criteriontheatre.org/Reel Pizza - https://www.reelpizza.net/now-playingMonteverde Cloud Forest, Costa Rica - https://www.visitcostarica.com/blog/visit-monteverde-cloud-forest-biological-reserveGreat Salt Lake Shrinking story - https://www.cbsd.com/9798890920096/the-once-and-future-lake/ Wabanaki Tribal Nations:Houlton Band of Maliseet Houlton Band of Maliseet Indians | Littleton, ME (maliseets.net)Mi'kmaq Mi'kmaq Nation | Presque Isle, ME (micmac-nsn.gov)Passamaquoddy Tribe Indian Township Passamaquoddy Tribe @ Indian Township | Peskotomuhkati MotahkomikukPassamaquoddy Tribe Sipayik Sipayik Tribal Government – Sipayik (wabanaki.com)Penobscot Nation Penobscot Nation | Departments & Info | Indian Island, Maine Special Thanks/Woliwon: Guests: Dr. Sylvia TortiProducer: Gavin AllenPodcast Team: Becky Soctomah Bailey, Macy Flanders
In this episode of Real Good Denver, Ryan Estes sits down with Melissa Jenner, founder and CEO of Actvo.ai, a New Zealand company now thriving in Denver's startup scene. Melissa shares how Denver's global outreach brought her across the world, why she believes work should be a place people love, and how her AI-driven platform helps companies retain top talent by mapping out employee career pathways before burnout takes hold. The conversation dives into the unique culture of Denver's business ecosystem, the power of serendipity in founder connections, the craft beer influence on collaboration, and why collective intelligence makes this city special. Key Takeaways Denver's Global Magnetism: Economic development teams are actively recruiting international startups, making Denver a true global landing pad. Culture of Serendipity: Denver's tight-knit founder ecosystem creates constant collisions of opportunity through dinners, meetups, and a give-first mindset. Beer as a Business Model: Collaboration in Denver mirrors its craft beer scene—newcomers and legacy players help each other scale. The Future of Work: Actvo.ai helps employees see 12 possible work pathways, close skill gaps, and create proactive career conversations before they leave a company. Equity over Equality: Melissa argues for tailored support to unlock overlooked talent, ensuring people find meaningful work. Collective Intelligence: Denver's culture of shared ideas and generosity accelerates innovation beyond the traditional Silicon Valley model. Frameworks Mentioned The 12 Pathways of Work – Actvo.ai's model to help employees explore new roles. Exit Lounge Effect – why companies lose 40% of employees after 2–5 years and how to prevent it. Equity vs Equality – supporting employees differently to reach the same starting point. Flywheel Effect of Collective Intelligence – how networks of generous founders compound innovation. Resources & Links Actvo.ai: https://www.actvo.ai Denver Economic Development and Opportunity (DEDO): https://www.denvergov.org/economicdevelopment Denver Startup Week: https://www.denverstartupweek.org Ratio Beerworks: https://www.ratiobeerworks.com Reverence Brewing: https://www.reverencebrewingco.com Golden, CO breweries: https://visitgolden.com Kitcaster: https://www.kitcaster.com
Pathways: Becoming Beloved 8-24-25 by LifePath Church
Jessica Bartnick, co-founder and CEO of Foundation for C.H.O.I.C.E, joins us to illuminate the power of mentorship in transforming the lives of students from low socioeconomic backgrounds. With "CHOICE" meaning "Consider how One Individual Changes Everything," Jessica shares how her organization's mission is deeply personal, inspired by her husband's success as a first-generation college graduate. We explore how the foundation navigates the complexities of the college application process, connecting students with mentors who guide them through a transformative 27-week curriculum. This structured support has led to an impressive 85% graduation rate among participants, flipping the script on dropout statistics that often overshadow students from challenging backgrounds. Step into the world of business integration as we discuss how the Foundation for Choice provides critical exposure to professional environments, forming partnerships with businesses to sustain its impactful work. The stories of Law, a refugee from Burma who triumphed over adversity to earn a full scholarship and pursue a medical career, and Stephen, who leveraged the program to build a successful life in banking, serve as testaments to the foundation's success. As Jessica underscores the vital role of donations in maintaining their work, we invite you to support this life-changing mission by visiting their website and engaging with their social media platforms. Don't forget to leave a review for the Legacy Podcast to help us reach more listeners eager to hear such inspiring stories. Timestamps 00:00:00 - Introduction and Welcome to the Business Legacy Podcast 00:00:10 - Introduction of Jessica Bartnick and the Foundation for Choice 00:01:20 - The Meaning Behind "CHOICE" and the Program's Inspiration 00:02:45 - Navigating the College Application Process and Program Structure 00:04:30 - Success Rate and Impact on Graduation Statistics 00:06:15 - Identifying and Supporting Students in the Middle Range 00:09:58 - Empowering Youth Through Business Integration 00:10:30 - Strategic Partnerships with Businesses and Program Funding 00:11:45 - Success Story: Law's Journey from Refugee to Medical School 00:13:00 - Success Story: Stephen's Path to a Banking Career 00:14:00 - The Role of Donations and How to Support the Foundation 00:15:00 - Closing Remarks and Call to Action for Listeners 00:15:30 - Encouragement to Leave a Review and Final Thoughts 00:16:00 - Where to Find More Information About the Podcast and Foundation Episode Resources: Connect with Jessica here: https://foundationforchoice.org/ Legacy Podcast: For more information about the Legacy Podcast and its co-hosts, visit businesslegacypodcast.com. Leave a Review: If you enjoyed the episode, leave a review and rating on your preferred podcast platform. For more information: Visit businesslegacypodcast.com to access the shownotes and additional resources on the episode.
In this second part of the message, we uncover more ways and climates that must exist, in order to access the voice of God.
When you tune into God, His direction becomes clear, precise and seamless. In this message, we uncover various climates that must be maintained in order to hear the voice of God, as well as various ways we can access the voice of God.
In this episode of This is the Panhandle, Broc sits down with colleague Beth Gunn, Grant Program Officer at the Amarillo Area Foundation. Beth shares her personal journey—from starting with the foundation through CYD, to leading scholarship programs, and now focusing on education grants. Together, they explore the concept of Opportunity Youth—young people ages 16–24 who are disconnected from education or the workforce—and why addressing their needs is critical for the future of the Texas Panhandle. Beth unpacks local research, the challenges of tracking this population, and the values-driven insights gathered directly from youth voices. Listeners will hear how collaboration among schools, workforce boards, foster care, and nonprofits is reshaping how the community supports these young people. From summits to policy changes, Beth highlights the Foundation's role in convening partners, funding innovative solutions, and shifting narratives about what young people truly want: connection, meaning, and the chance to make a difference. Beth also shares the personal motivation behind her work, revealing how her own experiences inform her passion for helping others navigate systems and access opportunity.
Join Physique University (free for 2 weeks) to engineer your best physique using our science-based fat loss and muscle-building blueprint—Why can two people follow the same diet and training plan but get completely different results? Could your DNA explain why fat loss feels harder, or why recovery takes longer? And is genetic testing the breakthrough it claims to be or just another fitness gimmick?With me is Joe Cohen, founder and CEO of SelfDecode, to separate the science from the scams. Joe shares what your genes can actually tell you about building muscle, losing fat, and preventing disease, and where the industry is misleading you. We also dig into how combining genetic data with lab work creates actionable steps you can measure and adjust over time.Tune in to discover whether your DNA could be the missing piece in your fitness journey.Today, you'll learn all about:0:00 – Intro2:17 – Why most DNA health tests fail6:44 – Marketing hype vs real science9:59 – Moving beyond the fitness basics12:01 – Diseases genetics can predict well16:38 – Universal habits vs targeted actions18:15 – How SelfDecode prioritizes recommendations22:43 – Genes and training insights27:22 – Pathways and functional genetics31:17 – Combining genetics with lab work38:07 – Joe's story of food intolerance45:45 – Where to learn more about SelfDecodeEpisode resources:Website: SelfDecode.comInstagram: @mrbiohacker Facebook: @selfdecode X: @SelfDecode Support the show
In this episode, Kristen is joined by Dr. Becky Whetstone, marriage crisis manager, therapist, and author, for an eye-opening conversation on why relationships break down, how to spot the earliest warning signs, and what you can do before it's too late. https://marriagecrisismanager.com/ When you purchase Dr. Becky Whetstone's book through this Amazon affiliate link, you're helping support the podcast at no extra cost to you: I (Think) I Want Out: What to Do When One of You Wants to End Your Marriage: https://www.amazon.com/dp/0757325394/ref=cm_sw_r_as_gl_api_gl_i_E1ZTTFG2JN1H19CMTMMN?linkCode=ml1&tag=boice01-20&linkId=5a20bbff76415d864c7d0359849b2afe Subscribe and get a free 5-day journal at www.kristendboice.com to begin closing the chapter on what doesn't serve you and open the door to the real you. This information is being provided to you for educational and informational purposes only. It is being provided to you to educate you about ideas on stress management and as a self-help tool for your own use. It is not psychotherapy/counseling in any form. This information is to be used at your own risk based on your own judgment. For my full Disclaimer please go to www.kristendboice.com. For counseling services near Indianapolis, IN, visit www.pathwaystohealingcounseling.com. Pathways to Healing Counseling's vision is to provide warm, caring, compassionate and life-changing counseling services and educational programs to individuals, couples and families in order to create learning, healing and growth.
Have you survived domestic violence, sexual trauma, or the loss of a loved one to murder? Have you faced systemic failures that deeply impacted your life or family? TWTDNH is a podcast confronting the realities of domestic violence, murder, untreated PTSD, traumatic brain injuries, and institutional neglect. It's a space for truth-telling — where stories are met with compassion, visibility, and dignity. Now seeking fellow podcasters and subject matter experts to help amplify voices the system has failed to hear.
On this second episode in our Pathways to PwC Series, we speak with Greg Rowley, a Tax Partner at PwC. Greg shares his experience going to Community College and what his transition into Accounting was like. He also discusses the CPA exam, how he found PwC and much more.
Pathways: No Rules, Just Rest 8-17-25 by LifePath Church
Join host Liz Unruh as she sits down with David McCleary, a veteran, who shares his heartfelt story of navigating mental health challenges. Discover how he found support through Riverside's outpatient Pathways program, and learn about the vital resources available to veterans in the community.
Chaps, The Rabbit and Browny chat about The legendary efforts of Jye Gray, Tallis Duncan and Jai Arrow
In this episode of The New Chemist's Podcasting Group's — The Path to KOLs, host David Ferguson sits down with Christine Hollis, Chief Talent & Diversity Officer at Marshall Gerstein. Christine has dedicated her career to guiding scientists and engineers into impactful roles within intellectual property law, bridging the worlds of innovation and legal protection.She shares insights on:Pathways for STEM talent to enter IP law as patent agents or technical specialists.The skills scientists bring to legal environments and innovation ecosystems.Strategies for diversity, equity, and inclusion in science-driven law.The future of STEM-law collaboration in an era of AI, biotech, and medtech.Whether you're a student, scientist, or innovator, Christine's vision will broaden your perspective on how STEM expertise can shape industries beyond the lab.Disclaimer: These episodes do not constitute medical or professional advice. These are only for intellectual engagement. Please see your local and board-certified health professional for medical advice, consultation, and suggestions.Music by Viacheslav Starostin from Pixabay
Author Connie Mutel joins the "ROI" panelists to discuss Tending To Iowa's Land: Pathways To A Sustainable Future.The host for the 623rd edition in this series is Terri Toppler, and the history buffs are Rick Sweet and Ed Broders.Opinions expressed in this program are those of the hosts and the guest(s), and not necessarily those of KALA-FM or St. Ambrose University. This program is recorded at KALA-FM, St. Ambrose University, Davenport, Iowa, USA!
BONUS DISCUSSION: Author Connie Mutel joins the "ROI" panelists to discuss Tending To Iowa's Land: Pathways To A Sustainable Future.The host for the 623rd edition in this series is Terri Toppler, and the history buffs are Rick Sweet and Ed Broders.Opinions expressed in this program are those of the hosts and the guest(s), and not necessarily those of KALA-FM or St. Ambrose University. This program is recorded at KALA-FM, St. Ambrose University, Davenport, Iowa, USA!
A panel of hematology leaders discusses the latest in ALL and T-cell ALL therapy, including TKI+blina combinations, venetoclax strategies, and the emerging role of CD7 CAR T-cell therapies in reshaping treatment paradigms.
Michele Barrett and Diane Hallman are two mothers who have been given extraordinary challenges raising children whose gifts include diagnoses of ADHD, AUDDHD, and autism. Today, recognizing the unique needs of children on the spectrum—particularly those on what they term the “autism cliff”—and eager to help them smoothly transition from secondary educational placements to college and beyond--they are creating a residential transition program called Pathways to Purpose. The program is different than other programs in its approach to empower high-masking, neurodivergent young adults (18-26) in Pennsylvania—who are typically overlooked and “assumed fine”--with skills, support, and structure before burnout and other mental and physical health issues develop. Joining them on the episode is Nicholas Myers, Michele's son, who gives voice to the need for such a program. They are inviting help in establishing a steering committee to develop the program—financial advisors, counselors, educators--and they welcome you to connect with them: dhallman@approachadvisors.com, mbarrett132@comcast.net.
As Pres. Trump & Putin meet in Alaska, without Pres. Zelensky, to discuss a peace deal in the Russian-Ukrainian War, it is not at all certain that any land will in fact be swapped for peace, as suggested by Pres. Trump. But one thing is for certain - that Pres. Putin will not, ever, swap Crimea for any land in Ukraine. In this episode, my guest and I discuss the history of Crimea and the Crimean Tatars.
From the beautiful shores of Maui, this candid conversation dives deep into the current state of Taekwondo with the raw honesty that listeners have come to expect from these Olympic veterans.The hosts dissect a controversial Poomsae scoring incident that rocked the National Championships, questioning why an unprecedented formal report was issued when a competitor was added to finals after initially placing 12th. What makes this situation particularly noteworthy is how tournament officials removed video evidence and implemented a response dramatically different from how fighting controversies are typically handled. This raises profound questions about transparency and organizational priorities that affect competitors at all levels.As conversation shifts to the upcoming Under-21 Pan Am Games, the hosts provide expert analysis on each weight division and the qualification pathways to the Olympics. Their disappointment that the United States only qualified competitors in four divisions reveals a concerning trend about development priorities in American Taekwondo. The qualification structure potentially allows young winners direct entry to the Olympic Games - creating an alternative pathway that could reshape competitive careers.Perhaps most fascinating is the hosts' exploration of when fighters reach their physical prime in modern Taekwondo. Their surprising consensus that today's athletes peak between 18-23 years old - much earlier than previous generations - reflects how dramatically the sport has evolved. This shift raises important questions about athlete development, career longevity, and the changing technical demands of competitive Taekwondo.Throughout the discussion runs a thread of wisdom about humility in martial arts. As one host eloquently states, success is "rented, not owned" - a powerful reminder about perspective that transcends sport. Whether you're a competitor, coach, or passionate fan, this episode offers invaluable insights from those who've experienced Taekwondo at its highest levels.Join us next Friday when we'll analyze the Pan Am Games results with special guest Dr. Capner. Your perspective matters - what changes have you observed in competitive martial arts development?
What if the real work of leadership wasn't about climbing higher, but going deeper into the soul, the body, and the sacred responsibility of showing up fully alive? In this soul-stirring conversation on The Greatness Machine, Darius sits down with Nathanael Chawkin for a deep dive into the sacred masculine, conscious leadership, and the power of integration. From personal initiations through plant medicine to the spiritual responsibility of leading in the modern world, this episode explores what it means to live a wholehearted, embodied life. Nathanael shares insights from his work guiding men through transformational rites of passage, and challenges the performative narratives of power and success. They also reflect on the rise of conscious capitalism, the illusion of enlightenment, and the true crucibles of growth—like marriage, fatherhood, and leadership itself. In this episode, Darius and Nathanael will discuss: (00:00) Introduction and Background (02:57) The Journey of Fatherhood (05:30) Exploring Masculinity and Leadership (08:34) The Role of Plant Medicine in Personal Growth (11:29) Integration and Spiritual Development (14:11) Personal Experiences with Plant Medicine (24:57) Exploring Plant Medicines and Spiritual Experiences (30:13) The Shift from Materialism to Conscious Leadership (36:56) Conscious Capitalism and the Role of Guardianship (42:46) Integrating Spirituality and Material Life (50:23) The Pathways of Development in Leadership Nathanael Chawkin is a modern mystic, master coach, and martial arts instructor with over 15 years of experience guiding executives and leaders through transformational growth. He is the founder of Guardian Training, a men's work methodology that blends MMA, conflict resolution, and depth psychology to awaken the sacred masculine. In 2021, he launched Awakening Leadership, a plant medicine journey for conscious leaders, and in 2025, co-founded Temple of The Living Truth with his life partner Elizabeth—a priestess of the sacred feminine. Together, they are building a decentralized spiritual community rooted in direct mystical experience. Featured in Entrepreneur and The Financial Times, Nathanael brings a uniquely embodied and integrative lens to leadership, spirituality, and human potential. Sponsored by: Constant Contact: Try Constant Contact free for 30 days at constantcontact.com. Express VPN: Secure your online data today with ExpressVPN. Go to expressvpn.com/darius. Indeed: Get a $75 sponsored job credit to boost your job's visibility at Indeed.com/darius. Shopify: Sign up for a $1/month trial period at shopify.com/darius. Jerry: Save $1,300/year on car insurance with Jerry at Jerry.ai/greatness. [DISCLAIMER: *Based on drivers who switched and saved with Jerry over the past twelve months. Over 20% of drivers who switched with Jerry found a monthly premium of $87 or less. Not all drivers find savings.] Connect with Nathanael: Website: https://awakeningleadership.org/ LinkedIn: https://www.linkedin.com/in/nchawkin Instagram: https://www.instagram.com/nathanael.chawkin/ Connect with Darius: Website: https://therealdarius.com/ Linkedin: https://www.linkedin.com/in/dariusmirshahzadeh/ Instagram: https://www.instagram.com/imthedarius/ YouTube: https://www.youtube.com/@Thegreatnessmachine Book: The Core Value Equation https://www.amazon.com/Core-Value-Equation-Framework-Limitless/dp/1544506708 Write a review for The Greatness Machine using this link: https://ratethispodcast.com/spreadinggreatness. Learn more about your ad choices. Visit megaphone.fm/adchoices
Part 1: From the Wrong Fix To The Right IssueMost of us spend our lives treating the wrong problem—an endless cycle of trying to do and be more. In this first episode of A Pathway to Living Free, we uncover the oldest lie in the Book and why it still shapes the way we see God, ourselves, and each other. You'll hear why the real problem isn't your weakness, but your misunderstanding of the God who's already made His home in you—and why seeing this changes everything.Learn more at Larksite.com ______________________________________________________________________Helping You Learn To Live Loved...Become a Lark Supporter: https://larksite.com/donateWeb: https://larksite.comLarkcast: https://larksite.com/larkcastBook: Reclaim (Available on Amazon) https://larksite.com/reclaimInstagram: https://www.instagram.com/lark_social/
In this part-two episode, Kristen continues the conversation with internationally recognized BPD expert and author Dr. Daniel Lobel, diving into the lasting impact of having a parent with borderline personality disorder, and how to begin healing and reclaiming your identity. Mysideofthecouch.com When you purchase Dr. Daniel Lobel's books through these Amazon affiliate links, you're helping support the podcast at no extra cost to you: 1. Adult Children of Borderline Parents: https://amzn.to/4l0ZmPS 2. When Your Daughter Has BPD: Essential Skills to Help Families Manage Borderline Personality Disorder: https://amzn.to/4kIrt6v 3. When Your Mother Has Borderline Personality Disorder: A Guide for Adult Children: https://amzn.to/4mU99Zu 4. When a Loved One Has Borderline Personality Disorder: A Compassionate Guide to Building a Healthy and Supportive Relationship: https://amzn.to/4mSP4TB 5. Stop Walking on Eggshells for Parents: How to Help Your Child (of Any Age) with Borderline Personality Disorder without Losing Yourself: https://amzn.to/4kvqQNt When you purchase these books through these Amazon affiliate links, you're helping support the podcast at no extra cost to you: 1. Sticky Note Mantras: The Art and Science of Choosing Your Thoughts: https://amzn.to/3IpHCiT Book Recommendations: 1. The Four Agreements: A Practical Guide to Personal Freedom (A Toltec Wisdom Book: https://amzn.to/453lBPO 2. Brain Lock, Twentieth Anniversary Edition: Free Yourself from Obsessive-Compulsive Behavior: https://amzn.to/44tRZuJ Subscribe and get a free 5-day journal at www.kristendboice.com to begin closing the chapter on what doesn't serve you and open the door to the real you. This information is being provided to you for educational and informational purposes only. It is being provided to you to educate you about ideas on stress management and as a self-help tool for your own use. It is not psychotherapy/counseling in any form. This information is to be used at your own risk based on your own judgment. For my full Disclaimer please go to www.kristendboice.com. For counseling services near Indianapolis, IN, visit www.pathwaystohealingcounseling.com. Pathways to Healing Counseling's vision is to provide warm, caring, compassionate and life-changing counseling services and educational programs to individuals, couples and families in order to create learning, healing and growth.
In this episode of the Getting Smart Podcast, Tom Vander Ark dives into the intersection of education and workforce innovation with Kerry McKittrick, Co-Director of Harvard's Project on Workforce. Together, they explore the evolving job market in the AI era, discussing challenges like the "AI job apocalypse" and the importance of creating agile pathways to economic mobility. Kerry highlights the critical role of work-based learning, industry partnerships, and personalized career navigation to prepare learners for a complex and dynamic workforce. Tune in to hear about the future of work, education's response, and how regional and adaptive pathways can create equitable opportunities for all. Outline (00:00) Introduction: AI's Impact on Jobs (02:27) Pathways to Economic Mobility (04:12) Current Job Market Challenges (09:05) Education's Response to Workforce Changes (14:21) Governors' Role in Workforce Development (24:58) Conclusion and Future Work Links Watch the full video here Read the full blog here Kerry McKittrick | LinkedIn Bloomberg Philanthropies CTE Initiative Harvard Project on Workforce
Did you know that 68% of Americans don't have a valid will or estate plan? For homeowners, this could mean leaving their loved ones with a costly, time-consuming probate process. Potentially losing up to 8% of their estate's value.In this episode, I sit down with Oscar Vasquez, founder of EstateDocPrep.com, to discuss why estate planning isn't just for the wealthy. It's for anyone who wants to protect their home, assets, and family. Oscar shares practical insights, real-life examples, and essential steps homeowners can take to avoid unnecessary legal battles and financial burdens. This is an episode you can't afford to miss!About Oscar (in his words)Hi, I'm Oscar Vasquez, founder of EstateDocPrep.com. Did you know that 68% of Americans don't have a valid will or estate plan? For homeowners, this means their loved ones could face the harsh reality of lengthy, expensive probate processes, often losing up to 8% of the estate's value in fees. I specialize in helping families avoid these unnecessary burdens by creating living trusts and other essential legal documents. I bring practical insights, real-life examples, and a clear message: estate planning isn't just for the wealthy—it's for anyone who wants to protect their home, assets, and family. Discover how a simple step like creating a living trust can save time, money, and stress, ensuring their legacy is passed down without complications. About Theresa:A wife and a mother to two children and grandmother, Theresa Alexander Inman is a Parenting Coach, Board Certified Behavior Analyst, Infant Toddler Development Specialist, Autism Spectrum Disorder Clinical Specialist. Introduced to behavior analysis in 2007 after years in the juvenile justice system.Her goal is to improve the lives of children and families by helping them strategize child develop skills to prevent or reduce the effects of possible delays while having fun! She also served as a panelist on the first annual Autism World Summit.Theresa is also an author, having published “Pathways to Early Communication” in 2022.Connect with Theresa today!• Instagram | Theresa Inman• LinkedIn | Theresa Inman• BabyBoomer.org | Theresa Inman• YouTube | Parenting with Confidence• Tiktok | https://www.tiktok.com/@parentcoachtheresa• Spotify via Anchor.fm | Parenting with Confidence Website: https://www.theresaalexanderinman.com/About Parenting on the SpectrumRaising autistic children comes with unique joys, challenges, and learning moments. Join host Theresa as she explores the diverse experiences of parenting kids on the spectrum. Each episode features expert insights, real-life stories, and practical strategies to help you navigate this journey with understanding, compassion, and strength. Whether you're a parent, caregiver, or ally, this podcast is your go-to resource for fostering connection and celebrating neurodiversity. Thank you for watching or listening. Please share, comment, rate, and download! Peace & Light! Theresa
So Russell went to Voice of Dentistry 2025 popup at the wonderful Pathways and had a blast. He did a few podcasts as he is want to do. In this podcast he and Dr. Michael Hess talk with Cliff Campbell and Ricky Rivera of StellaLife about their products and dentistry in general. Ricky is a lab tech turns salesman and Cliff comes from a line of dental salesmen. If you want to contact either one of them to place an order for StellaLife, their emails are CliffCampbell@Stellalife.com and RRivera@Stellalife.com. StellaLife makes a great product.
BUFFALO, NY - August 13, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 29, 2025, titled “PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion.” In this study, led by first author Jassy Mary S. Lazarte and corresponding author Nazarius S. Lamango from Florida A&M University College of Pharmacy and Pharmaceutical Sciences, researchers investigated a new class of compounds called polyisoprenylated cysteinyl amide inhibitors (PCAIs) as a potential treatment for aromatase inhibitor (AI) therapy resistant breast cancer. Aromatase inhibitors are a common treatment for estrogen receptor-positive (ER+) breast cancer, but many patients eventually develop resistance, leaving fewer therapeutic options. The study focused on a PCAI compound called NSL-YHJ-2-27, which was tested in long-term letrozole-treated breast cancer cells (LTLT-Ca), an experimental model of AI therapy resistance. NSL-YHJ-2-27 activated two major signaling pathways, MAPK and PI3K/AKT. Although these pathways typically support cancer cell survival, their overstimulation by PCAIs led to increased oxidative stress, damaging the cells and inducing cell death by apoptosis. The compound also reduced levels of RAC1 and CDC42, proteins involved in maintaining cell shape and movement. These alterations resulted in cytoskeletal disruption and reduced structural integrity, making the cancer cells more vulnerable and less capable of spreading. Importantly, the effects of NSL-YHJ-2-27 persisted after the compound was removed, suggesting long-term control over AI resistant cancer cells may be possible. “PCAIs inhibited cell proliferation and colony formation by 95% and 74%, respectively, increased active caspase 7 and BAX 1.5-fold and 56%, respectively. NSL-YHJ-2-27 (10 μM) induced LTLT-Ca spheroid degeneration by 61%.” As a new class of targeted molecules, PCAIs represent an innovative approach distinct from traditional endocrine therapies. Their ability to affect multiple cellular mechanisms simultaneously makes them promising candidates for future drug development. Overall, this study presents a promising new approach for treating AI therapy-resistant breast cancer. By targeting cellular pathways that support survival and mobility, PCAIs like NSL-YHJ-2-27 could provide a novel strategy to manage advanced or resistant forms of the disease. Further research, including in vivo studies and clinical trials, will be essential to confirm these findings and evaluate their therapeutic potential. DOI - https://doi.org/10.18632/oncotarget.28759 Correspondence to - Nazarius S. Lamango - nazarius.lamango@famu.edu Video short - https://www.youtube.com/watch?v=8xQEilloO9Q Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28759 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PCAIs, ROS, MAPK, PI3K/AKT, LTLT-Ca cells To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
In this episode of the Immigration Conversation podcast, Partner Cosmina Morariu and Business Immigration Manager Ayana Ibrahimi are joined by Lara Dyer, Chief Program Officer (Americas) at Talent Beyond Boundaries (TBB), to explore Canada's Economic Mobility Pathways Pilot (EMPP). The EMPP merges Canada's humanitarian and economic priorities, enabling employers to hire skilled refugees from around the world.Together, Fragomen and TBB have created an innovative, award-winning business-driven solution enabling skilled refugees to legally migrate for work, benefitting both displaced professionals and economies struggling with skills and labor shortages.
Recorded at the Evidence Based Perioperative Medicine (EBPOM) World Congress 2025 in London, this piece focuses upon pioneering work in ambulatory surgical care and enhanced recovery pathways. Presented by Andy Cumpstey with his guest Dr. Anoushka Afonso, Associate Professor of Clinical Anesthesiology at Memorial Sloan Kettering Cancer Center (MSK), where she is the Director of Enhanced Recovery Program. Hear how standardized care protocols, non-opioid analgesia, and real-time locating systems help to provide a higher standard for patients. Also, we look at the future of personalized care and the critical importance of 'Returning to Intended Oncological Therapy' (RIOT) for cancer patients.
In Episode 68, hosts Houston Blackwood and Kailah Dozier talk with David Walters, Vice Chancellor of Adult Education and Correctional Education for the Alabama Community College System to discuss the vital role of adult education in Alabama's workforce development.David shares how programs like the GED, High School Diploma Option Program, and digital literacy certifications are creating new opportunities for adult learners across the state. From improving economic outcomes to supporting justice-involved individuals, this conversation dives into how education and workforce training go hand-in-hand to change lives and build stronger communities.If you're interested in how seamless educational pathways, practical skill-building, and collaboration are shaping Alabama's workforce, this episode is for you.
In this insightful episode, Gary Kleiban and Benny Rogers tackle the intricacies of pro player development in the United States. Starting with a listener question on coaching U9 girls using the 3four3 methodology, they emphasize treating young players with the same foundational principles as older groups--focusing on possession, structure, and adaptation across formats like 7v7 […] The post Ep 392: Unlocking Pro Player Development – Pathways, Odds, and Longevity in American Soccer appeared first on 3four3.
In this episode, Theresa sits down with Katharine Giovanni to explore the transformative power of forgiveness. Together, they discuss personal stories, strategies for letting go, and the freedom that comes with embracing forgiveness. Tune in for an inspiring conversation filled with insight and hopeAbout Katharine:Katharine Giovanni, a three-time award-winning best-selling author, speaker, and one of the original founders of the independent concierge industry. She's the author of more than a dozen books, including her latest The Ultimate Path to Forgiveness: Unlocking Your Power.Katharine's journey is one of extraordinary resilience. She's a stage 3 breast cancer survivor who overcame a traumatic childhood, and those experiences now fuel her mission to help others heal. Through her work as a Transformation Mentor and Intuitive, Katharine empowers people to release guilt, shame, and emotional blocks, guiding them toward lasting freedom and self-awareness.About Theresa:A wife and a mother to two children and grandmother, Theresa Alexander Inman is a Parenting Coach, Board Certified Behavior Analyst, Infant Toddler Development Specialist, Autism Spectrum Disorder Clinical Specialist. Introduced to behavior analysis in 2007 after years in the juvenile justice system.Her goal is to improve the lives of children and families by helping them strategize child develop skills to prevent or reduce the effects of possible delays while having fun! She also served as a panelist on the first annual Autism World Summit.Theresa is also an author, having published “Pathways to Early Communication” in 2022.Connect with Theresa today!• Instagram | Theresa Inman• LinkedIn | Theresa Inman• BabyBoomer.org | Theresa Inman• YouTube | Parenting with Confidence• Tiktok | https://www.tiktok.com/@parentcoachtheresa• Spotify via Anchor.fm | Parenting with Confidence Website: https://www.theresaalexanderinman.com/About Parenting on the SpectrumRaising autistic children comes with unique joys, challenges, and learning moments. Join host Theresa as she explores the diverse experiences of parenting kids on the spectrum. Each episode features expert insights, real-life stories, and practical strategies to help you navigate this journey with understanding, compassion, and strength. Whether you're a parent, caregiver, or ally, this podcast is your go-to resource for fostering connection and celebrating neurodiversity. Thank you for watching or listening. Please share, comment, rate, and download! Peace & Light! Theresa
In this episode, Kristen sits down with Licensed Professional Counselors and co-authors of Sticky Note Mantras, Helene Zupanc and Beth Valdez, to explore how simple, personal mantras can shift negative thought patterns and bring more self-compassion, humor, and joy into everyday life. stickynotemantras.com When you purchase these books through these Amazon affiliate links, you're helping support the podcast at no extra cost to you: 1. Sticky Note Mantras: The Art and Science of Choosing Your Thoughts: https://amzn.to/3IpHCiT Book Recommendations: 1. The Four Agreements: A Practical Guide to Personal Freedom (A Toltec Wisdom Book: https://amzn.to/453lBPO 2. Brain Lock, Twentieth Anniversary Edition: Free Yourself from Obsessive-Compulsive Behavior: https://amzn.to/44tRZuJ Subscribe and get a free 5-day journal at www.kristendboice.com to begin closing the chapter on what doesn't serve you and open the door to the real you. This information is being provided to you for educational and informational purposes only. It is being provided to you to educate you about ideas on stress management and as a self-help tool for your own use. It is not psychotherapy/counseling in any form. This information is to be used at your own risk based on your own judgment. For my full Disclaimer please go to www.kristendboice.com. For counseling services near Indianapolis, IN, visit www.pathwaystohealingcounseling.com. Pathways to Healing Counseling's vision is to provide warm, caring, compassionate and life-changing counseling services and educational programs to individuals, couples and families in order to create learning, healing and growth.
On this episode in our Pathways to PwC series, we speak with Kathryn Kaminsky, PwC's Chief Commercial Officer and Kyle Moffatt PwC Partner who share their own nontraditional paths into the profession. Together, they share how their early experiences shaped their careers — and how students from all backgrounds can find their place at a firm like PwC. Whether you are exploring accounting for the first time or looking for a way in, their stories offer insights, encouragement and proof that your path is valid— and full of potential.
Today we welcome Ruth Vichos onto the R2Kast!