Podcasts about states

AP's Lisa Dwyer reports on potential regulation changes for Head Start programs.

Chuck Todd opens with the Iran war's arrival on American soil: hackers have hit water systems across multiple states in one of the most serious cyberattacks on U.S. water infrastructure in years and investigators probing an Iranian link. Trump's response tells you everything about the presidency in its current state — he didn't blame the attacker, he blamed the victim, using the hack as an occasion to attack Minnesota Democrats. Chuck’s question hangs over the whole segment: was Trump briefed on the Iranian connection and went after Minnesota anyway? Either way, the first instinct was to find a Democrat to blame, which Chuck calls a kind of polarization disease that leaves a president caring more about his narrative than about American citizens drinking the water. It fits a pattern the episode keeps circling: Jeanine Pirro presented false evidence to a grand jury blaming a former Olympian for damage to the White House reflecting pool, dropped the case when Interior produced documents proving otherwise, and Trump publicly disagreed with dropping it because he still insists it was vandals. Chuck argues negative information never reaches Trump, and people who bring him bad news don't last long — which is how you end up with a president insisting affordability is a Democratic scam Then, Chuck highlights a Wall Street Journal piece that lays out Trump's corruption — roughly $800 million raised through what amounts to an advertised pay-to-play scheme. Anti-corruption is a devastating midterm message sitting right there for Democrats to pick up… then Chuck Schumer rolled out a bill that Chuck calls a piece of garbage: it wouldn't even cover the conduct in the WSJ story, it's likely unconstitutional because it names individuals, and — most absurdly — it creates a new anti-corruption agency inside the executive branch, meaning a corrupt president would appoint its director and seven board members and, per the Supreme Court, could fire them at will. Congress can already do every bit of the oversight the agency would perform and Schumer's answer to executive corruption is to hand the executive more power and write Congress out of its own job. He closes on Michigan and Wisconsin as the clearest signals of where the Democratic Party is headed — Abdul El-Sayed running a movement inside a Senate race with the explicit goal of changing the party, DSA-endorsed Francesca Wong leading in Wisconsin while the establishment fails to coordinate against her — and on the DSA's new call to abolish the Senate, which Senate Democrats pushed back on without ever defending the institution. Chuck defends it himself: the Senate is a feature, not a bug, a brake on political extremism, and the right response to losing an argument is to win it rather than rewrite the rules. Then, Dr. Brian King — the former director of the FDA's Center for Tobacco Products, who was placed on administrative leave in April 2025 as part of the mass HHS layoffs joins the Chuck Toddcast to explain what happens to public health when the agency charged with protecting it gets deliberately dismantled. King walks through the extraordinary progress America made reducing cigarette smoking over decades, and how quickly that's being unwound: the tobacco industry donated millions to Trump's PAC, executives pressured the White House directly, and the payoff has been regulatory capture and mounting pressure on the FDA to bring flavored products back to market. He's clear-eyed rather than absolutist on the science — combustible products are far and away the most harmful, nicotine itself is highly addictive but isn't what's killing people, though it's genuinely not risk-free for the adolescent brain — and he walks Chuck through the comparison to caffeine, the data on whether vaping serves as a gateway back into smoking, and what's actually known about nicotine pouches, where youth usage isn't high but stubbornly isn't declining either. The industry, meanwhile, is spending roughly a million dollars an hour advertising its products while fighting every government action to reduce smoking. The conversation turns to what actually works and what's being abandoned. King argues the two most effective interventions available are reducing nicotine levels in cigarettes and banning menthol, credits Congress for getting the Tobacco Control Act right, and stresses that Congress — not the FDA acting alone — has to be the one to regulate tobacco, which is precisely why sidelining the agency is so damaging. He and Chuck get into the questions nobody in Washington wants to answer: why are cigarettes legal at all, how are sugary alcoholic beverages not treated in the same category, and where did the money from the 1998 master settlement actually go. King is pointed that the MAHA movement, for all its rhetoric about chronic disease, has done nothing prominent on tobacco, and that the FDA is now actively undermining both the science and the law it was built to enforce. His closing warning is the bleakest note of the episode: America is in a public health apocalypse that will take decades to repair, it will be enormously hard to recruit a next generation into the field, the entire world will be harmed by the collapse of American public health infrastructure — and the impacts are only just beginning to show up. Finally, Chuck hops into the ToddCast Time Machine to revisit Watergate and Richard Nixon’s resignation, and answers listeners’ questions in the “Ask Chuck” segment. Play ball and swing for the fences on FanDuel, an official partner of the MLB at https://FANDUEL.COM. Protect your family with life insurance from Ethos. Get up to $3 million in coverage in as little as 10 minutes at https://ethos.com/chuck. Application times may vary. Rates may vary. For free and unbiased Medicare help, dial (980) 734-3985 to speak with my trusted partner, Chapter, or go to askchapter.org/chuck /*Paid Partnership Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Timeline: (Timestamps may vary based on advertisements) 00:00 Chuck Todd’s introduction 06:15 The Iran war has become a global conflict 06:45 Once again Trump issues threats, then walks them back 08:15 War is one of biggest strategic mistakes in decades 09:00 Increased gas prices have cost households additional $560 10:30 CISA warns that Iranian hackers are targeting water infrastructure 11:15 Iran could cause unreliability to the American water supply 13:00 Trump used hacking attacks to blame Minnesota Democrats 13:45 Trump didn’t blame the attacker, he blamed the victim 15:30 Jeanine Pirro blamed former Olympian for damage to reflecting pool 16:00 Dept. of Interior had documents proving otherwise, Pirro dropped case 17:00 Pirro presented false evidence to a grand jury 18:30 Trump publicly disagreed with Pirro dropping case, says it was vandals 19:30 Trump’s staff is shielding him from the truth 21:00 Trump’s lack of understanding reality is terrible for him 21:30 Trump’s low approval is a midterm disaster in the making 23:00 Stephanie Grisham says 85% of negative info is kept from Trump 24:15 People who bring Trump bad news don’t last very long 25:30 Republicans aren’t campaigning like things are going well 26:00 Ken Paxton puts out an affordability agenda, looks like a Dem proposal 27:15 Trump still saying affordability is scam made up by Democrats 28:15 Trump can’t understand the reality of the situation 28:45 Was Trump briefed on Iran hack… then attacked Minnesota anyway? 30:00 Trump’s first instinct was to find a Democrat to blame 30:45 Trump is demented with polarization disease 31:15 Trump cares more about his narrative than American citizens 32:15 Trump is bragging about his grifting an Americans are tired of it 33:15 Anti-Corruption is a massively effective midterm strategy 33:45 Chuck Schumer rolls out a stinker of an anti-corruption bill 34:45 WSJ publishes airtight piece about Trump’s overt corruption 35:45 There’s no buffer or plausible deniability for Trump in the corruption story 36:45 Trump is basically advertising that government is a pay to play scheme 37:45 There’s a list of presidential promises for favors that have been bought 38:15 Trump has raised $800m in pay for play schemes with little accounting 39:00 There is no law outlawing a president from raising unlimited money 39:30 Trump is now the biggest alligator in the swamp 40:15 Schumer’s bill is a piece of garbage, why many senators didn’t sign on 41:45 Jamie Raskin is performing oversight, Schumer wants agency to do it for him 42:30 The bill wouldn’t even cover the corruption outlined by the WSJ story 44:00 The bill is unconstitutional because it names individuals 45:00 Laws can target behavior, not individuals. It’d be thrown out in court 45:45 The agency Schumer proposed would live in the executive branch 46:15 Agency to stop a corrupt president would be staffed by the president?? 47:15 SCOTUS says president can fire the heads of exec branch agencies 48:45 If bill passed, Trump would pick agency head and 7 members of board 49:15 Congress can perform all the oversight the proposed agency would do 50:30 Congress could stop all this corruption if it wanted to 52:00 Schumer’s idea is to hand more power to the executive branch??? 54:30 The plan from congress is to write themselves out of oversight? 57:00 Schumer’s bill will never see the light of day 57:45 Michigan & Wisconsin will show where the Democratic party is headed 59:30 Abdul El-Sayed made clear his goal is to change the Democratic party 1:00:15 His campaign is a movement inside a senate race 1:01:00 Francesca Wong in Wisconsin is frontrunner & endorsed by DSA 1:01:45 Establishment hasn’t coordinated well to stop Wong 1:02:15 Movement politicians are usually right about the future, wrong about present 1:03:30 Sometimes the movement comes first, sometimes the coalition does 1:04:00 DSA has become a force, and is now calling for abolishing the senate 1:05:00 Senate democrats pushed back, but didn’t defend the senate 1:05:45 The senate is a feature, not a bug 1:06:30 The senate is a brake on political extremism 1:07:15 The response is to win the argument, not rewrite the rules 1:08:00 Movement nominees are easier to defeat than governing ones 1:14:15 Brian King (FDA center on tobacco) joins the Chuck ToddCast 1:18:00 We made incredible progress reducing cigarette smoking 1:18:30 Tobacco companies donated and received regulatory capture 1:19:15 Flavored vapes appeal more to kids & are problematic 1:20:45 Trump was pressured by executives from tobacco industry 1:21:30 There were multimillion dollar donations to Trump’s PAC 1:23:00 What’s the actual health data on nicotine outside of smoking? 1:23:30 Combustible products are the most harmful 1:24:00 Nicotine is highly addictive but isn’t causing the harm and deaths 1:24:45 Nicotine can harm the adolescent brain, it’s not risk free 1:25:30 Comparing nicotine vs. caffeine 1:27:15 Vaping typically isn’t a gateway back into smoking 1:28:30 There’s been pressure on FDA to bring back flavored products 1:31:00 $1M dollars an hour is being spent advertising tobacco products 1:31:45 Industry has been fighting all government action to reduce smoking 1:33:15 The FDA has been sidelined in the fight against smoking 1:33:45 Why are cigarettes even legal at all? 1:35:15 Tobacco farmers have transitioned to other crops in other countries 1:37:15 Reducing nicotine levels is highly effective 1:37:45 Outlawing menthol is also highly effective 1:39:30 Congress got it right with the Tobacco Control Act 1:41:15 How are sugary alcoholic beverages not in the same category? 1:42:15 What is age gating technology and how does it work? 1:44:15 Do we have good data on usage for people under 18? 1:46:45 Nicotine pouch usage isn’t high amongst kids, but isn’t going down 1:47:15 What is the data about health impacts from pouches? 1:48:45 Nicotine has a strong stimulant effect, helps with attention 1:49:30 Settlement in ‘98 required tobacco companies to pay costs in perpetuity 1:50:00 States have diverted those funds to other purposes 1:51:00 Did the tobacco industry actually take a hit from the settlement? 1:51:45 If still at FDA, what changes would you implement? 1:52:15 FDA has been undermining the science and the law 1:53:15 Effectiveness of banning indoor smoking 1:54:30 Should preventing underage addictions be the north star? 1:56:45 Congress has to regulate tobacco, FDA can’t do it on its own 1:57:30 MAHA hasn’t done anything prominent on tobacco 1:59:45 Is there litigation that could be pursued here? 2:01:00 We’re in a public health apocalypse, will take decades to repair 2:01:45 It will be hard to recruit people into public health 2:03:30 The entire world will be harmed by collapse of American public health 2:05:15 The impacts are just beginning to show up, will get worse 2:07:00 Toddcast Time Machine - The five days that ended Richard Nixon 2:07:30 Nixon resigned 52 years ago, this week 2:08:15 Why is Nixon the only president that paid a price for his corruption? 2:09:15 We tell the story of Watergate backwards and start with resignation 2:10:30 The June arrests weren’t the beginning of Watergate 2:12:15 We don’t know what Nixon’s operation learned before the arrests 2:14:00 We never got full answer on the missing 18 minutes 2:14:45 Supreme Court stayed in session during summer to oversee Watergate 2:15:15 Smoking gun tape goes public six days after the break-in 2:16:00 Nixon needed 34 votes in the senate to survive, only had 16 2:16:45 Impeachment in the house was a foregone conclusion 2:17:15 Senators didn’t demand he resign, just showed Nixon the numbers 2:20:30 How different would history have looked had Nixon survived? 2:21:15 Ask Chuck 2:21:30 Is presidency becoming more powerful in a way that could outlast Trump 2:24:30 Can the U.S. government create a true unbiased media source? 2:28:15 Would mandatory voting create better political participation? 2:32:45 Would Illinois make for a better early primary state? 2:34:30 Why not hold every primary on the same day? 2:36:45 Personal anecdote about AI job displacement and fearSee omnystudio.com/listener for privacy information.

Dr. Brian King — the former director of the FDA's Center for Tobacco Products, who was placed on administrative leave in April 2025 as part of the mass HHS layoffs joins the Chuck Toddcast to explain what happens to public health when the agency charged with protecting it gets deliberately dismantled. King walks through the extraordinary progress America made reducing cigarette smoking over decades, and how quickly that's being unwound: the tobacco industry donated millions to Trump's PAC, executives pressured the White House directly, and the payoff has been regulatory capture and mounting pressure on the FDA to bring flavored products back to market. He's clear-eyed rather than absolutist on the science — combustible products are far and away the most harmful, nicotine itself is highly addictive but isn't what's killing people, though it's genuinely not risk-free for the adolescent brain — and he walks Chuck through the comparison to caffeine, the data on whether vaping serves as a gateway back into smoking, and what's actually known about nicotine pouches, where youth usage isn't high but stubbornly isn't declining either. The industry, meanwhile, is spending roughly a million dollars an hour advertising its products while fighting every government action to reduce smoking. The conversation turns to what actually works and what's being abandoned. King argues the two most effective interventions available are reducing nicotine levels in cigarettes and banning menthol, credits Congress for getting the Tobacco Control Act right, and stresses that Congress — not the FDA acting alone — has to be the one to regulate tobacco, which is precisely why sidelining the agency is so damaging. He and Chuck get into the questions nobody in Washington wants to answer: why are cigarettes legal at all, how are sugary alcoholic beverages not treated in the same category, and where did the money from the 1998 master settlement actually go. King is pointed that the MAHA movement, for all its rhetoric about chronic disease, has done nothing prominent on tobacco, and that the FDA is now actively undermining both the science and the law it was built to enforce. His closing warning is the bleakest note of the episode: America is in a public health apocalypse that will take decades to repair, it will be enormously hard to recruit a next generation into the field, the entire world will be harmed by the collapse of American public health infrastructure — and the impacts are only just beginning to show up. Play ball and swing for the fences on FanDuel, an official partner of the MLB at https://FANDUEL.COM. Protect your family with life insurance from Ethos. Get up to $3 million in coverage in as little as 10 minutes at https://ethos.com/chuck. Application times may vary. Rates may vary. For free and unbiased Medicare help, dial (980) 734-3985 to speak with my trusted partner, Chapter, or go to askchapter.org/chuck /*Paid Partnership Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Timeline: (Timestamps may vary based on advertisements) 00:00 Brian King (FDA center on tobacco) joins the Chuck ToddCast 03:45 We made incredible progress reducing cigarette smoking 04:15 Tobacco companies donated and received regulatory capture 05:00 Flavored vapes appeal more to kids & are problematic 06:30 Trump was pressured by executives from tobacco industry 07:15 There were multimillion dollar donations to Trump’s PAC 08:45 What’s the actual health data on nicotine outside of smoking? 09:15 Combustible products are the most harmful 09:45 Nicotine is highly addictive but isn’t causing the harm and deaths 10:30 Nicotine can harm the adolescent brain, it’s not risk free 11:15 Comparing nicotine vs. caffeine 13:00 Vaping typically isn’t a gateway back into smoking 14:15 There’s been pressure on FDA to bring back flavored products 16:45 $1M dollars an hour is being spent advertising tobacco products 17:30 Industry has been fighting all government action to reduce smoking 19:00 The FDA has been sidelined in the fight against smoking 19:30 Why are cigarettes even legal at all? 21:00 Tobacco farmers have transitioned to other crops in other countries 23:00 Reducing nicotine levels is highly effective 23:30 Outlawing menthol is also highly effective 25:15 Congress got it right with the Tobacco Control Act 27:00 How are sugary alcoholic beverages not in the same category? 28:00 What is age gating technology and how does it work? 30:00 Do we have good data on usage for people under 18? 32:30 Nicotine pouch usage isn’t high amongst kids, but isn’t going down 33:00 What is the data about health impacts from pouches? 34:30 Nicotine has a strong stimulant effect, helps with attention 35:15 Settlement in ‘98 required tobacco companies to pay costs in perpetuity 35:45 States have diverted those funds to other purposes 36:45 Did the tobacco industry actually take a hit from the settlement? 37:30 If still at FDA, what changes would you implement? 38:00 FDA has been undermining the science and the law 39:00 Effectiveness of banning indoor smoking 40:15 Should preventing underage addictions be the north star? 42:30 Congress has to regulate tobacco, FDA can’t do it on its own 43:15 MAHA hasn’t done anything prominent on tobacco 45:30 Is there litigation that could be pursued here? 46:45 We’re in a public health apocalypse, will take decades to repair 47:30 It will be hard to recruit people into public health 49:15 The entire world will be harmed by collapse of American public health 51:00 The impacts are just beginning to show up, will get worseSee omnystudio.com/listener for privacy information.

Govs. Josh Stein (D-N.C.) and Phil Scott (R-Vt.) join Kristen Welker for a Common Ground conversation on the balance of power between the states and the federal government.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This is the All Local 4:00 P.M. update for Sunday, August 2, 2026.

Ever feel like politicians and pundits are using words like socialism, communism, and social democracy as boogeymen without actually explaining what they mean? You aren't alone.In this episode of Carmen Talk, Carmen takes a step back from the political noise to break down complex economic frameworks into simple, everyday terms. Prompted by an uplifting reminder of American hospitality from international World Cup visitors, Carmen dives into the definitions we hear tossed around daily—using simple analogies like a neighborhood bakery and iconic pop culture references like Star Trek: The Next Generation.In this episode, we unpack:The Bakery Breakdown: What communism, socialism, social democracy, and capitalism look like using a simple bakery example.Star Trek & Democratic Socialism: How the world of Captain Picard models an ideal where basic human needs are met and individual achievement isn't driven by money.Social Democracy vs. Democratic Socialism: Why countries like Norway and Denmark thrive under capitalism paired with strong social safety nets.The U.S. Mixed Economy: Why our current system isn't pure capitalism and where our tax dollars actually go.Cutting Through the Division: Why understanding these terms helps us stop fighting over misinformation and focus on empathy, compassion, and taking care of each other.Correction Note: During the conversation regarding DSA, the correct organization name is the Democratic Socialists of America (DSA).Thank you for stopping by.  Please visit our website: All About The Joy and add, like and share.  You can now watch the livestream version of the show on YouTube at @CarmenLezeth You can also support AATJ by shopping at our STORE - Or by and buying us a coffee. We'd appreciate that greatly.  Also, if you want to find us anywhere on social media, please check out the link in bio page. Music By Geovane Bruno, Moments, 3481Editing by Team A-JHost, Carmen Lezeth DISCLAIMER:  As always, please do your own research and understand that the opinions in this podcast and livestream are meant for entertainment purposes only. States and other areas may have different rules and regulations governing certain aspects discussed in this podcast.  Nothing in our podcast or livestream is meant to be medical or legal advice. Please use common sense, and when in doubt, ask a professional for advice, assistance, help and guidance. 

Ken Roczen posted a reel of himself doing normal, unglamorous strength training. No BOSU balls, and none of the sport-specific fluff we're all used to seeing. So I had to bring on Ben Greenwood, founder of Race Ready Offroad Coaching, to break down why that clip mattered so much to him. Ben's been coaching off-road racers for almost a decade now, and he doesn't sugarcoat it. Most of us skip the boring fundamentals because they don't look cool on Instagram, and then we wonder why our bodies fall apart by our thirties.We get into it all, man. Why an eight-week program is basically a joke when you actually do the math on how many times you touch a barbell. His own back locking up at 30 years old and thinking his racing career was over. How a "qualified" nutritionist almost sent him into the ground chasing a keto diet while he was training like a maniac. And since he flew out to the States earlier this year, we compare GNCC to Australian off-road racing, why you can actually walk out and watch your rider on track over here but not over there, and we go down the Josh Strang and Shane Watts rabbit hole because I had to ask who the greatest Aussie export to make it in America really is.If you're a vet rider just trying to keep riding your dirt bike without your body falling apart, this one's for you. Go follow Ben on Instagram at @offroadperformancecoach and check out Race Ready Offroad Coaching if you want to actually build a program instead of guessing. If you're enjoying the show, please subscribe and leave a review, it really helps more riders find us. Enjoy getting seat time and we'll see you next episode.Support the show

Plus: Nuclear company Westinghouse Electric has confidentially filed for an IPO. And New York sues Kalshi, saying the company is running an illegal gambling operation. Alex Ossola hosts. Sign up for WSJ's free What's News newsletter. An artificial-intelligence tool assisted in the making of this episode by creating summaries that were based on Wall Street Journal reporting and reviewed and adapted by an editor. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Cheat Sheet is The Murder Sheet's segment breaking down weekly news and updates in some of the murder cases we cover. In this episode, we'll talk about cases from Indiana, West Virginia, Texas, and London, England. The BBC's article on Johannes Kongsnes Natland and the Foxtrot Network: https://www.bbc.com/news/articles/cwyqggvyp1doEuropol's statement on Johannes Kongsnes Natland and the Foxtrot Network: https://www.europol.europa.eu/how-we-work/operations/operational-taskforce-grimmABC's article on Johannes Kongsnes Natland and the Foxtrot Network: https://abcnews.com/International/wireStory/norwegian-teenager-convicted-role-murder-hire-ordered-iran-135193057WTOV-9 on the murder of Donna Barger and the arrest of David Barger: https://wtov9.com/news/local/weirton-police-conducting-murder-investigationThe Intelligencer-Wheeling News Register on the murder of Donna Barger and the arrest of David Barger: https://www.theintelligencer.net/news/top-headlines/2026/07/murder-investigation-under-way-in-weirton-one-woman-dead/The Electronic Frontier Foundation's report on Johnson County, Texas and Flock cameras: https://www.eff.org/deeplinks/2025/10/flock-safety-and-texas-sheriff-claimed-license-plate-search-was-missing-person-it404 Media's report on Johnson County, Texas and Flock cameras: https://www.404media.co/a-texas-cop-searched-license-plate-cameras-nationwide-for-a-woman-who-got-an-abortion/Check out our upcoming book events and get links to buy tickets here: https://murdersheetpodcast.com/eventsPre-order our book on Delphi here: https://bookshop.org/p/books/shadow-of-the-bridge-the-delphi-murders-and-the-dark-side-of-the-american-heartland-aine-cain/21866881?ean=9781639369232Or here: https://www.simonandschuster.com/books/Shadow-of-the-Bridge/Aine-Cain/9781639369232Or here: https://www.amazon.com/Shadow-Bridge-Murders-American-Heartland/dp/1639369236Join our Patreon here! https://www.patreon.com/c/murdersheetSupport The Murder Sheet by buying a t-shirt here: https://www.murdersheetshop.com/Check out more inclusive sizing and t-shirt and merchandising options here: https://themurdersheet.dashery.com/Send tips to murdersheet@gmail.com.The Murder Sheet is a production of Mystery Sheet LLC.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

An absolute battle is unfolding! From sanctuary states refusing to turn over voter data to wild border developments unfolding overseas, this episode breaks down how tools like the SAVE database are exposing non-citizen voter registrations, triggering DOJ criminal investigations, and igniting the ultimate showdown over election integrity and national security!

Guest Mark Meckler, Convention of States, joins to discuss the end of the US Senate session. What did they actually get done? Discussion of Republicans working with the Trump agenda and preparing for midterm season 2026. Discussion of SAVE America Act, GOP leadership in the Senate, and more.  Guest Buddy Mason, Revelation Gold Group, joins to discuss the latest in gold and silver market, precious metal investments, and more. Who's buying gold right now, and will there be another jump in value? 

After more than three decades, San Francisco prosecutors have charged Ricky Dawson in the 1992 rape and strangulation of Nancy Hernandez, a 45-year-old woman found dead in a Chinatown alley. Dawson, already serving life for a 1996 Denver murder and previously convicted in a Florida killing, has now been linked by DNA to at least four deaths spanning California, Colorado, Florida, and possibly Washington. This episode examines how cold-case DNA technology connected the crimes, the pattern investigators see across state lines, and what the charges mean for a case that sat unsolved for 34 years.

States all around the country are waking up to the fact that an income tax is bad for their economy. Several have already moved to eliminate their state income tax. But there's a trap awaiting those who simply replace income tax revenue with a higher sales tax. AFFT president Steve Hayes lays it all out in this week's Chairman's Report.

Robach and Holmes cover the latest news headlines and entertainment updates and give perspective on current event in their daily "Morning Run." See omnystudio.com/listener for privacy information.

Robach and Holmes cover the latest news headlines and entertainment updates and give perspective on current event in their daily "Morning Run." See omnystudio.com/listener for privacy information.

Robach and Holmes cover the latest news headlines and entertainment updates and give perspective on current event in their daily "Morning Run." See omnystudio.com/listener for privacy information.

A majority of states are demanding more regulation of the billion-dollar prediction market industry, while federal regulators have sided with the companies in their lawsuits against state regulation laws. MS NOW's Ali Velshi shares the latest. Then, men are more scarce in HEAL careers, short for health care, education, administration, and literacy, than women are in STEM. Darby Saxbe argues that the best way to improve prestige and pay for the women in these fields is to get more men into them, and she points to the history of computing as an example. And, cannabis has become a popular sleep aid, but while THC — one of its main active ingredients — has been shown to induce drowsiness and sleep, research shows cannabis may actually make sleep quality worse. University of Calgary neuroscientist Matthew Hill tells us about the interaction between cannabinoids, sleep and stress.See pcm.adswizz.com for information about our collection and use of personal data for sponsorship and to manage your podcast sponsorship preferences.NPR Privacy Policy

Pediatric Telehealth That Actually Works: 24/7 Access, All 50 States, Real Outcomes Host: Janae Sharp Guests: Lyndsey Garbi, MD, co-founder and CMO of Blueberry Pediatrics Pediatric access is broken, and parents, payers, and health systems are all feeling it. Lyndsey Garbi, MD, co-founder and CMO of Blueberry Pediatrics, joins Megan Antonelli to talk about what 24/7 pediatric telehealth actually looks like at national scale, what the at-home diagnostic kit changes for families, and why the licensing patchwork is quietly costing kids access to care. Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen/

Eighteen state attorneys general, led by Nebraska, have filed suit against Gavin Newsom and California over a plastics law that forces manufacturers nationwide to redesign their packaging — or lose access to the California market. The constitutional argument is straightforward: no single state gets to set environmental policy for the entire country. Red states are saying enough.The law Newsom signed in 2022 creates a so-called producer responsibility system — which is a polished way of saying companies pass the costs straight to consumers. It also includes carve-outs that conveniently protect industries with ties to Sacramento, while ordinary businesses in Montana, Indiana, and a dozen other states get squeezed by regulations their own voters never approved.The deeper issue is one California keeps testing: because it's the largest economy in the country, whatever Sacramento mandates effectively becomes national policy. That's exactly what this lawsuit is challenging. Whether the courts agree will determine whether one state can permanently hold the rest of the country's supply chain hostage to its environmental politics. We'll follow this one closely as it moves through the courts.CHAPTERS0:00 The Recycling Myth in California1:00 17 States Sue California Over Plastic…1:32 Nebraska AG Leads Anti-California…2:20 How Little Plastic Actually Gets…3:49 Newsom's 2022 Plastics Law Under…4:40 Producer Responsibility Laws Push…6:10 Real Plastic Pollution Sits in…7:01 Lawsuit Claims California Overreaches…7:47 Even Environmental Groups Sue Over…9:34 Environmentalists Oppose Chemical…10:30 Why Home Composting Beats the…12:54 Policy Lawsuits as Political Resume…13:59 Why 16 Governors Banded Against…Subscribe to @reasonablenews and hit the notification bell so you don't miss the update when the ruling drops.#GavinNewsom #CaliforniaPolitics #BillionaireTaxGO PREMIUM WITH REASONABLE+ FOR UNCENSORED ACCESS

Arkansas Governor Sarah Huckabee Sanders has officially rebranded June away from Pride Month — and five Republican-led states are right behind her. From Tennessee's Nuclear Family Month to Alabama's Strong Families Month to Nebraska's Marriage and Family Month, red states are pushing back against what many conservatives call decades of corporate and political rainbow-washing. This is a coordinated cultural statement, not a fringe move.Sean breaks down the full list of states, what they're declaring instead, and why the mainstream media — especially here in the Pacific Northwest — won't touch this story. The corporate machine behind Pride Month has run unopposed for years. That's changing fast, and the left's response reveals exactly how high the stakes are in this fight over American values.Meanwhile, Seattle marches the other direction, and Sean has thoughts. From the Seattle Times cheerleading a World Cup crowd to the Pacific Northwest's relentless LGBTQ advocacy overreach, the contrast between red-state America and the Puget Sound bubble has never been sharper. Pride as a deadly sin, pronoun culture in Washington, and why "Strong Families Month" is a statement worth making.CHAPTERS0:00 Gov. Sanders Scraps Pride Month in…1:54 Seattle Media Avoids LGBTQ Criticism2:42 Anti-LGBTQ Nations Play Seattle Pride…4:06 MLB Cracks Down on Bible Verse Hats5:33 Pride as a Deadly Sin6:13 Six GOP Governors Counter Pride Month8:57 Sarah Huckabee Sanders Promotes Family…9:48 Tennessee Declares Nuclear Family Month10:30 Alabama Governor Declares Strong…13:14 Rapinoe Skips Patriotism at World Cup14:42 Nebraska Declares Marriage and Family…15:40 LGBTQ Groups Slam GOP June Rebranding18:40 Rep. Andy Ogles Deletes Anti-Gay PostSubscribe to @reasonablenews and hit the notification bell — daily commentary on the stories the Pacific Northwest media won't cover.#MediaBias #MainstreamMedia #CensorshipGO PREMIUM WITH REASONABLE+ FOR UNCENSORED ACCESS

Luke Gives us the picture of Jesus in the home of Martha in Luke chapter 10 verses 38 through 42.They lived in the village of Bethany. Jesus is teaching and Mary is seated at His Feet listening to His word.Luke records the comparison between Mary and her sister Martha. Martha was busy with making preparations for the Lord and his disciples.Dr. Mitchell brings out the fact that the two sisters both loved the savior. The good thing that Mary had chosen would not be taken away from her. She was seated at Jesus' feet listening to His word.We are reminded that Luke is also the gospel of Prayer.In chapter 11, the disciples heard Jesus praying and wanted Him to teach them how to pray and so He teaches them the model prayer.Here's Dr Mitchell on the Unchanging Word Bible Broadcast, Luke chapter 10 verse 38.

The Trump administration's war in the Middle East has driven up fuel prices globally. As drivers pay more at the pump, some oil-rich states like New Mexico and Alaska are experiencing a tax revenue windfall. In this episode, one man's gas spend becomes another man's state budget booster. Plus: The Fed holds rates steady despite internal disagreement, “kidulting” and collectibles fuel growth in the toy retail space, and a line dancing resurgence driven by social media launches one instructor's boot scootin' career.Every story has an economic angle. Want some in your inbox? Subscribe to our daily or weekly newsletter.Marketplace is more than a radio show. Check out our original reporting and financial literacy content at marketplace.org — and consider making an investment in our future.Read the stories in today's episode:Oil-producing states benefit from war-driven windfallAdults are spending big on toysWhat happens if the AI bubble pops?How one entrepreneur is riding a wave in popularity for line dancing

The Trump administration's war in the Middle East has driven up fuel prices globally. As drivers pay more at the pump, some oil-rich states like New Mexico and Alaska are experiencing a tax revenue windfall. In this episode, one man's gas spend becomes another man's state budget booster. Plus: The Fed holds rates steady despite internal disagreement, “kidulting” and collectibles fuel growth in the toy retail space, and a line dancing resurgence driven by social media launches one instructor's boot scootin' career.Every story has an economic angle. Want some in your inbox? Subscribe to our daily or weekly newsletter.Marketplace is more than a radio show. Check out our original reporting and financial literacy content at marketplace.org — and consider making an investment in our future.Read the stories in today's episode:Oil-producing states benefit from war-driven windfallAdults are spending big on toysWhat happens if the AI bubble pops?How one entrepreneur is riding a wave in popularity for line dancing

The Constitution Study with Host Paul Engel – I've often said that people have the right to be stupid. If we think about it, States also have a right to be stupid, unless their citizens force them to change. After announcing that their state erroneously registered 6,600 non-citizens to vote, New Jersey Governor claimed that Donald Trump's claims of thousands of non-citizens being registered to...

Sustainability conversations usually center on ecosystems, emissions targets, and corporate pledges, but this episode makes the case that people belong at the center of that conversation too. Andrew looks at how communities living closest to refineries, extraction sites, and industrial waterfronts carry a disproportionate share of the pollution burden, often without having consented to the risk in the first place. Using a Philadelphia refinery as a case study, Andrew walks through how fenceline communities experience higher poverty rates, higher rates of residents of color, and elevated cancer and respiratory risk compared to their surrounding cities. He extends that pattern to wildfire response, contrasting how affluent California communities were able to evacuate and rebuild after the Santa Ana wind fires with how remote Northern Ontario and Arctic communities, some with only one road in and one road out, had to be airlifted out entirely. The episode also revisits New York's Hudson River, once devastated by industrial chemical runoff and now home to returning oysters, menhaden, and whales after decades of restoration work. The back half of the episode turns to policy. As federal environmental justice efforts recede in 2026, states including Minnesota, Illinois, and Massachusetts are stepping into that gap, and nonprofit legal teams are winning court challenges against federal rollbacks. Andrew closes with a reminder that protecting the environment and protecting people are frequently the same fight, and that sustainable business practices tend to protect local economies as much as they protect public health. Takeaways Communities near industrial facilities carry a disproportionate pollution burden, often without their consent Fenceline communities show higher poverty rates, higher percentages of residents of color, and elevated cancer and respiratory risk Wildfire evacuation capacity varies sharply by community resources and infrastructure The Hudson River's recovery shows environmental restoration is possible after decades of industrial damage States are advancing environmental justice policy as federal efforts recede in 2026 Courts have blocked some federal rollbacks of environmental justice funding Protecting the environment and protecting public health are frequently the same fight Support Independent Podcasts: https://www.speakupforblue.com/patreon Need help with your ocean non-profit, company, or project? Get the help you need with Pisces Oceans Inc.: https://www.piscesoceans.ca Connect with Speak Up For Blue Website: https://bit.ly/3fOF3Wf Instagram: https://bit.ly/3rIaJSG TikTok: https://www.tiktok.com/@speakupforblue Twitter: https://bit.ly/3rHZxpc YouTube: www.speakupforblue.com/youtube  

Big news!We've officially expanded into more states, allowing us to help even more buyers, homeowners, investors, and self-employed borrowers with their mortgage financing.In this week's Brief, Kenny Simpson shares:The new states we're licensed inWhy being a mortgage broker gives clients more optionsHow access to over 100 lenders helps find better loan solutionsWhy experience matters in today's marketHow we've invested in technology, AI, and client communication to deliver a better mortgage experienceWhy referrals continue to be the biggest part of our businessWhether you're buying your first home, refinancing, investing, or you're self-employed, we're here to help.

This week, Morgan is joined by Annwyn Avalon, water priestess, author, and someone who has spent the last 16 years walking the priestess path in Glastonbury, the real-life Avalon. The two connected in the wildest way (through a Morgan Le Fay post, of all things), and this conversation ends up going so much further than water. They talk about what priestessing really means at its core, the vision that led Annwyn to leave her life in the States behind, the ley lines running through Glastonbury, and what it actually looks like to live a devoted, sacred life day to day. For anyone who has ever felt the pull of Avalon, this one is for you. Annwyn is the author of Water Witchcraft, The Way of the Water Priestess, The Celtic Goddess Grimoire, and more. Find her at annwynavalon.com and waterpriestess.com. New episodes every Wednesday. Paid Patreon members' exclusive bonus content this week: Morgan and Annwyn continue their conversation, which switches includes Sulis, the water goddess of Bath, England. Join Morgan on her Patreon for exclusive bonus content. Visit https://patreon.com/inkedgoddesscreations for more details.    Consider joining Morgan's Inked Spirit Coven to deepen your magickal practice and connect with a supportive community. For more information, head to https://inkedspirit.com.   For unique witchy supplies and tips, a monthly Witchcraft subscription box, and more, head to https://www.InkedGoddessCreations.com. 

The guys are joined by Charlotte FC captain, and 2026 MLS All-Star Ashley Westwood, as Westy talks about the show Tim Ream put on last night at the MLS All-Star Skills Challenge, he tells you why he's embraced the All-Star events we do here in the States, and talks about the pending departure of Kerwin Vargas See omnystudio.com/listener for privacy information.

In this episode, host Sloan Simmons is joined by Lozano Smith's Title IX Practice Group Co-Chairs, Sarah Fama and Monica Batanero, to discuss the Supreme Court's opinion on two cases addressing transgender participation in girls' school athletics:  West Virginia v. B.P.J. and Little v. Hecox.  The discussion covers the Court's holdings, legal reasoning, and implications for schools navigating student participation, safety, and competitive fairness. The episode also explores the impact on California schools, including related Title IX issues, pending litigation, and challenges to California's existing legal framework. Show Notes & References 1:28 – Supreme Court rulings in West Virginia v. B.P.J. (2026) 609 U.S.  2:25 – Background on B.P.J. and Hecox cases 5:32 – What the Supreme Court decided 6:50 – Reasoning and analysis of the Court 8:00 – Justice Brett Kavanaugh, writing for the majority: “The term ‘sex' in the 1972 Title IX statute, the 1974 Javits Amendment, and the 1975 Title IX regulations cannot plausibly be interpreted to refer to anything other than biological sex. The ordinary meaning of the term ‘sex' at the time of enactment in the early 1970s was biological sex and not gender identity, particularly in the sports context.” 9:17 – Safety and competitive fairness 11:56 – Bostock v. Clayton County Georgia (2020) 590 U.S. 644 – (Client News Brief 86 – December 2020) 15:12 – Biological females who identify as male in male sports 17:31 – Concurrences and dissents of justices 19:16 – What happens now?  The state of the law in California 20:49 – Pending litigation in lower courts 21:28 – United States v. California Interscholastic Federation and California Department of Education, July 9, 2025 – (Client News Brief 31 – July 2025) 21:53 – United States v. Maine Department of Education (No. 1:25-cv-00173) 22:33 – Viability of challenges to U.S.A. v. CIF/CDE; AB 1266 and CIF Bylaws For more information on the topics discussed in this podcast, please visit our website at: www.lozanosmith.com/podcast   Disclaimer: As the information contained herein is necessarily general, its application to a particular set of facts and circumstances may vary. For this reason, this podcast episode does not constitute legal advice. We recommend that you consult with your counsel prior to acting on the information contained herein.

Listen to the Jay Garvens Home & Mortgage Show on KRDO News Radio 105.5FM & 1240AM at 8am this morning as Jay tells you about the “Presidential libraries – Abilene Kansas & Fly Over states! ... The post PRESIDENTIAL LIBRARIES – ABILENE KANSAS & FLY OVER STATES – 7-25-26 appeared first on Jay Garvens.

Being early and being wrong are the same position, and the original Bitcoin thesis, the one that expected people to figure it out quickly, was 90 percent wrong. Out of that error comes a working definition of value, and underneath it a definition of knowledge: arrangements that keep their shape as t

The Constitution Study with Host Paul Engel – I've often said that people have the right to be stupid. If we think about it, States also have a right to be stupid, unless their citizens force them to change. After announcing that their state erroneously registered 6,600 non-citizens to vote, New Jersey Governor claimed that Donald Trump's claims of thousands of non-citizens being registered to...

Two years after researchers identified ReNU syndrome, where are we now?   In 2024, two independent research teams identified the genetic cause of ReNU syndrome, a rare neurodevelopmental condition affecting thousands of people worldwide. The discovery marked the beginning of a new chapter for families searching for answers and opened up exciting new avenues for research.  In this episode, host Sharon Jones revisits the story to explore what has happened since that breakthrough. She is joined by: Professor Nicky Whiffin, Associate Professor and Wellcome Career Development Fellow at Big Data Institute and Centre for Human Genetics, University of Oxford Christina Cox, Co-founder of ReNU Syndrome UK and parent of a child with ReNU syndrome Dr Ana Lisa Tavares, Clinical Lead for Rare Disease at Genomics England Together, they discuss how researchers around the world have built on the original discovery to deepen our understanding of ReNU syndrome, why studying the non-coding regions of our DNA is revealing previously unknown rare conditions, and how collaboration between researchers, clinicians and families is accelerating progress. They also explore how the growing ReNU community is supporting newly diagnosed families and what the future could hold for new treatments.  Links:  Previous episode detailing the discovery of ReNU Syndrome  ReNU Syndrome UK's website  Original research paper from Nicky's team in Oxford  Original research paper from the team based in New York   “It's been only two years since our paper came out about this, and in that time, there are now patient family groups that have been set up all around the world. There is the one in the UK led by Christina and the others. There's the one in the US that's led by a group of four women, and there are ones in France, Spain, like, literally all around the world. And all of these groups are also somewhat coordinated. The leads of these groups meet with each other. They've organised meetups. I've been to ones in the US, the UK, and in France. So the fact that they can mobilise all of that and create such a community so quickly is absolutely incredible.”  You can download the transcript, or read it below. [00:00:00] Sharon: In 2024, two independent research teams identified a genetic cause of a rare neurodevelopmental condition affecting thousands of people around the world. Since then, that initial groundbreaking discovery has grown into something much bigger, bringing together families, researchers, and clinicians, and building a clearer picture of what we now know as ReNU syndrome.  [00:00:26] Sharon: Welcome to Behind the Genes, the podcast that covers everything from cutting-edge research to real-life stories in genomic healthcare. I'm Sharon Jones, and in today's episode, we're looking at what's happened since that discovery, what researchers are continuing to learn, and what the future could hold for people living with  ReNU Syndrome and their families.  [00:00:46] Sharon: To help us understand more, I'm joined by Professor Nicky Whiffin, Christina Cox, and Dr. Ana Lisa Tavares. So, two papers were published around the same time for this condition. To start us off, Nicky, you worked on one of these papers. Could you explain how this journey first began?   [00:01:05] Nicky: Yeah, so this was two years ago now, back in early 2024, where two research teams, so us based in Oxford and a, a group based in New York, were both looking at the data within the National Genomics Research Library, and we both kind of somewhat simultaneously found that there was variance in this very, very small gene, it's called RNU4-2, were found in individuals with previously undiagnosed neurodevelopmental disorders.  [00:01:39] Nicky: And this was very, very striking because we initially actually identified the same single DNA change or mutation in 40 or so different individuals within the National Genomics Research Library, and we normally expect to see a whole host of different variants. We don't expect to see the same one.  [00:01:59] Nicky: So this was a really, really surprising finding. And it was through a collaboration, large scale collaboration across the world where we started contacting our other collaborators who have similar collections of patients who have been genome sequenced to ask if they had any individuals with DNA changes in this gene.  [00:02:17] Nicky: And we found some in the US, some in, in Australia, some in France and Germany. So very, very quickly built up this, this complete picture of variants in this gene, causing this rare neurodevelopmental disorder   [00:02:35] Sharon: of people finding it at the same time, what, what did that feel like?  [00:02:39] Sharon: Like, give us a ense of, like, that compelling, "We think we found something." What was that like?   [00:02:46] Nicky: I didn't believe it initially. You're always told when you're a scientist that if it looks too good to be true, it's, it's not true, and this basically lit up like a beacon. There's this particularly one DNA change that we found in, um, I think it was about 40 different individuals, and we don't really expect that to be the case.  [00:03:04] Nicky: We normally expect these genetic variants to be somewhat randomly distributed across the genome. So to find 40 individuals with exactly the same DNA change was very, very surprising. So initially, I didn't believe it. The whole team, including folks at Genomics England, spent a lot of time trying to check that these variants were real and tried to disprove the result, tried to find any other way in which any other reason why we would be seeing this.  [00:03:31] Nicky: And after a little while, we had to concede that we couldn't disprove it, so it must be true, and that, that was a very exciting moment.   [00:03:38] Sharon Jones: Was it the case that over in the States, the exact same thing was happening?   [00:03:42] Nicky: I think we found out when we were both speaking at the same conference, actually. So we didn't actually know that we, that we'd both come across the same result.  [00:03:49] Sharon: If you want to check out our previous episode on this initial discovery, you'll find a link to it in the episode description.  [00:04:00] Sharon: So Christina, tell us a bit about your situation, your family situation, and for our listeners, what ReNU is.   [00:04:05] Christina: So ReNU is, to us, is a family. We got a family when we got diagnosed with  ReNU. Beau - Arabella - already had other diagnosises, but people had always said to us, "Oh, there's something else. There's something else.  [00:04:20] Christina: We're not sure what it is, but there will be something." And then when we got  ReNU, it was like, "Oh, okay, amazing. What do we do? What is it?" Because there was only four lines on Wikipedia when we first got told about it, and there wasn't anything that, ourselves could find. So we kind of went onto Facebook and looked for groups and different people, and there wasn't really anything except for Jess in America.  [00:04:46] Christina: And then it grew, and then it kind of, we ended up finding more people in the UK and, like, all over. But for us, it didn't really change how we perceived Beau. It just made life easier. Like, knowing there was other families out there that we could find advice from and support from, and that we kind of knew what we had and going forward then, like, finding researchers and connecting with everybody.  [00:05:15] Sharon: Yeah. And for those who don't know, can you talk about what  ReNU is? Like, how does it affect Beau?   [00:05:20] Christina: So with Beau and  ReNU , it affects her with developmental delay. She's non-verbal. She's incontinent. She suffers for walking, so she can do a little bit of walking, but she needs a wheelchair It affects her mood swings.  [00:05:38] Christina: It just affects everything. Although she has it, she's still a happy, outgoing, very stubborn, just kind of "keep-going" child. But it affects her in everything, like eating, sleeping.   [00:05:51] Sharon: It sounds like life is, you know, very challenging on a day-to-day basis, lots of considerations. How did you feel when you finally got this diagnosis after years of wondering and waiting, not knowing?  [00:06:02] Christina: Finding out was, like, really emotional because it was like, "Oh, wow, so we have this diagnosis. Now what? What are we looking for? What's going to happen?" And then we were kind of like, "Oh, but there's not many people that had it." Because we found out in the August, so then it was trying to find people. But it has been life-changing to know that we're not on our own and that there is other people around.  [00:06:28] Sharon: Yeah, tell us a bit more about that. How did it feel to get that diagnosis?   [00:06:32] Christina: It was quite strange because our pediatrician rang us and said, "Oh, we've got a diagnosis. She's got RNU4-2." And we were like, "Okay, so what's that?" And she's like, "I don't really know. There's four lines on Wikipedia at the moment."  [00:06:46] Christina: She goes, "I don't like Wikipedia," but we still kind of... That was it. So then we went on a mission to find and look for where we could find support and find other families.   [00:06:58] Christina: At that point, I didn't know of anybody in the UK, and my husband found Jessica in America. What then, kind of, we had somebody to talk to, and then families in the UK kind of started appearing.  [00:07:09] Christina: So we ended up getting a whole network of people to bounce ideas off and talk about how it affects their children and what's for the future and things like that. It was really nice.   [00:07:22] Sharon: Yeah, yeah, I can imagine. So Ana Lisa, how do these findings contribute to a growing understanding of the condition?  [00:07:29] Ana Lisa: So this was an amazing discovery. Although we're finding new rare conditions quite often, not on this sort of scale. It was also an amazing finding because a lot of the genes that we know are associated with rare conditions are genes that encode proteins, and in the 100,000 Genomes Project, we were doing whole genome sequencing, and Nicky and her team were looking in the parts of the genome that don't encode for proteins.  [00:08:03] Ana Lisa: And so this was, uh, exciting from that point of view as well. So the vast majority of our genome, more than 98%, does not encode for proteins, but it's relatively unexplored. And if we think about our genome and the letter code that makes it up, which is the manual for how our bodies are built, and grow and function day-to-day.  [00:08:30] Ana Lisa: Those 3 billion letters, if you, if you printed them out in a 12 font regular print, it would stretch so far you could fly, I think, from London to Paris several times, maybe three times or something. And so, this actual gene is a very, very small gene, less than 150 of those letters. So again, it was incredible to find that by comparing across many, many different genomes in the National Genomic Research Library.  [00:09:00] Ana Lisa: Going back to your question about a growing understanding of a condition, it was a completely new condition, but it also opened up looking at other related genes and actually now more disorders that are being found, like RNU2-2 by colleagues in the US, and that might be one of the most common recessive genetic neurodevelopmental disorders.  [00:09:27] Ana Lisa: So it's really, really opened up this understanding about these types of disorders and also those non-coding parts of our genome and the power of collaboration and being able to look across many different whole genomes at the same time.   [00:09:44] Sharon: Yeah. And Nicky, you've been involved in much of this research journey.  [00:09:50] Sharon: What have been some of the biggest advances or learnings for you so far?   [00:09:55] Nicky: I think the biggest one is just how common, or how frequent, these disorders are. So what we discovered recently in terms of new genetic disorders were rarer and rarer conditions, and that's why we hadn't seen them before. But from going from looking at the protein coding genes to looking at these non-coding genes, we found something that was as frequent as disorders that were found in the early 2010s when we first had large-scale sequencing projects that looked at the protein coding genes.  [00:10:26] Nicky: So that was really, really surprising. And we now know there's this whole class of disorders. So RN4-2, this gene encodes this -- Well, it produces this small RNA that works in this huge molecular machine that is called the Splicer Zone, that mediates the processing of most of the other genes across the genome.  [00:10:50] Nicky: And there are lots of these little RNAs that work in this molecular machine that are called the small nuclear RNAs or the snRNAs And we now know that there are a whole multitude of different disorders associated with different ones of these spliceosomal small nuclear RNAs, and that's really incredible.  [00:11:09] Nicky: And for RNU4-2 itself, we also now know that there are, there's not just RENE syndrome, uh, which is a dominant disorder caused by chance de novo variants that are newly arisen in a child, but also a recessive disorder where a child inherits one, uh, gene mutation from each parent. And also another finding that there is a region of the gene where we find DNA changes that cause retinitis pigmentosa, so a retinal phenotype. So we now know a huge amount more about this single gene, but also all of this different class of genes or RNAs that work in the same molecular machine, uh, which is, is really fascinating biologically   [00:11:52] Ana Lisa: Vicky, while you were talking, I was thinking about the splicing and how a bit like this podcast recording, you're going to splice out the kind of extreme, the noise that wasn't supposed to be there.  [00:12:03] Ana Lisa: And actually, you could make slightly different versions of this podcast, couldn't you? And that's, that's what, what's happening in our bodies for a lot of our genes that, that the kind of output can be varied slightly.   [00:12:15] Sharon: So Christina, how has collaboration been involved across the community and with researchers?  [00:12:21] Sharon: You know, what sort of things have you been doing?   [00:12:23] Christina Cox: So it's amazing to have researchers that are so open and amazing to work with the families. So at the moment, we are just putting together like a panel to discuss questions from families, to then be able to answer families, to work very closely with the researchers for what things are happening and the progress within.  [00:12:47] Christina: It's just amazing to be able to work with researchers. They're just fantastic.   [00:12:52] Sharon: And from what I understand, like, you, you have a charity, don't you? Can you tell us a bit more about that and how that came about?   [00:12:58] Christina: So we have ReNU Syndrome UK, and it came about as there was a group of us parents that were like, we wanted to be able to support other families, knowing what it was like for us when we first started.  [00:13:12] Christina: It was very difficult. So we wanted to start a charity that can support families and signpost them, give them the opportunity to have family meetups once or twice a year, so we can work with scientists and specialists to keep everybody in the community, like the ReNU family, up to date. But being able to connect with so many families, because a lot of the doctors don't really know of ReNU Syndrome yet.  [00:13:46] Christina: So if we have a problem or a question, we put it in the WhatsApp group, and then somebody can answer it because they've been through it, or they, they've just asked the question. So it's just an amazing resource for everybody   [00:14:02] Sharon Jones: That sounds amazing, and it sounds like you've all obviously become experts by experience.  [00:14:04] Sharon: So, like you say, you kind of know more, you know, as the science develops, but you're living it every single day   [00:14:10] Christina: It's kind of, you go into the hospital and they're like, "Oh, what's ReNU Syndrome?" And then you're like, "Ugh." So, then you just have to say it all. But, and then it's kind of them bringing, teaching new people who don't know about it in the medical professional.  [00:14:26] Christina: We always give them the website so that they can go and then find, but being able to put more medical stuff on the website, it just helps everybody, and it's just broadening it out to as many people as possible. Because there's still a lot of people undiagnosed with RNU syndrome. It's, now it's easier to be signposted, but it's just keeping that connection.  [00:14:49] Sharon: Yeah. And, and from what I understand, it's got quite an interesting sort of origin of a name, RNU. Where did that... Do you know much more about where that came from?   [00:14:57] Christina: So, Nicky is the amazing person who, um, sorted the name and um, the origin. So, I'll pass that over to Nicky to answer that question because she's just amazing   [00:15:11] Nicky: Uh, so the name ReNU syndrome is an interesting story.  [00:15:13] Nicky: So, a lot of disorders or diseases are named after people. So, we all know Alzheimer's, Parkinson's, etc. And they're often scientists or clinicians that have spent a lot of time working on them. I think that's a little bit odd. I don't think it's the first thing that somebody should know about a disorder, is the name of somebody who's, who's worked on it or studied it.  [00:15:36] Nicky: But they're a very, it's very hard to find an alternative. When we were initially doing the press release around our paper, we had a quote from one of the mothers, Nicole Cedar, who has a, a wonderful daughter called Mia Joy, and she said that within their family, they like to refer to RNU, to RNU4-2 as ReNU, which is a really nice play on the RNU in the gene name.  [00:16:00] Nicky: So then I had an idea, okay, let's just change the spelling to make the, the kind of big R, little E, large N-U, then it would link to the gene name, but also would be a name that speaks to hope and the renewed hope of being given a diagnosis.   [00:16:13] Sharon: Yeah, absolutely, and that's a great, a great story and a great way of kind of making it feel like there is, there is always hope.  [00:16:20] Sharon: So, you know, Nicky, you're now part of the patient community. In a way. You know, so how does it feel to be on that other side of it from that sort of research perspective and now kind of, you know, in that, in that community?   [00:16:34] Nicky: It's amazing. I've got a new family as well. It's not, not just Christina and everybody.  [00:16:39] Nicky: I kind of, I'm a, a basic scientist. I'm not a clinician. Up until this point, we've always been one or two steps removed from actually interacting with the families themselves. Um, so my life has changed an awful lot over the last couple of years, uh, where now, um, I kind of talk to Christina or the folks in the US, really regularly, kind of on a weekly basis.  [00:17:02] Nicky: Um, so that's really different. And I just kind of want to highlight just what these families have achieved. So it's been only two years since our paper came out about this, and in that time, there are now patient family groups that have been set up all around the world. There is the one in the UK led by Christina and and the others.  [00:17:26] Nicky: Um, there's the one in the US that's led by a group of four women, and there are ones in France, Spain, like, literally all around the world. And all of these groups are also somewhat coordinated. The leads of these groups meet with each other. They've organised meetups. I've been to ones in the US, the UK, and in France.  [00:17:46] Nicky: So the fact that they can mobilise all of that and create such a community so quickly is absolutely incredible. And they've got families, they've got so many researchers that are interested in the cause. They're interacting with the pharma companies. They've upskilled themselves to learn so much about genetics.  [00:18:04] Nicky: And it's just an absolutely incredible thing to watch. They're so, so inspiring.   [00:18:09] Sharon: And from what I understand, Christina, you feel, you know, very passionate about Nicky in the same way, about your paths crossing in this way.   [00:18:16] Christina: Oh, my, yes. Every time I see Nicky, I've met her a couple of times, like, in person now, I just cry.  [00:18:22] Christina: I literally, we saw her at the UK meetup, and she walked in the door, and that was it. I was done. I was like, it's just meeting somebody who has changed so many lives and brought a community to other families. It's just amazing. And the support that Nicky's giving us weekly, daily, is just amazing. It is just life-changing for all of us.  [00:18:49] Sharon Jones: It's such a powerful connection. So Ana Lisa, why is collaboration between researchers, clinicians, and families so valuable in the rare disease research space? You know, and what role do large scale research projects and data sharing play in discoveries like this?   [00:19:06] Ana Lisa: Collaboration is completely incredibly valuable and for progress in the rare disease space where there's just so much still to learn.  [00:19:16] Ana Lisa: So more than half of patients and families where, uh, they're seeking a potential diagnosis, we're not yet able to, to find one, and there's so much yet that we still need to learn, and collaboration in so many different spaces and directions and across different spheres enables this progress. So for example, the fact that we have a really connected, uh, National Health Service and really close working between the NHS and Genomics England so that we can, for those patients and families that, that consent to their de-identified data being shared in the National Genomic Research Library, be able to work with many, many different researchers, uh, whether they're academic, institutions, industry, and try and find all the patients that could benefit from a new diagnosis and, uh, potentially new therapies in future clinical trials.  [00:20:21] Ana Lisa: And without that collaboration, it would be really, really hard to find all those people So because we sort of have a clinical research interface where we can go back to clinical teams and therefore to patients and families, even if there's a really, really ultra-rare condition with very few people known to have it that could be under different specialties in different regions, we would be able to contact their clinical team.  [00:20:51] Ana Lisa: So I think that, that collaborative working with the NHS is really powerful across researchers worldwide. Like in this example where a group in Oxford and a group in US were able to make this finding and then all the other findings that are coming from it. And really, without being able to compare across thousands of genomes, one wouldn't have been able to see this, this particular signal and see that there were more than 100 patients, and that was really powerful.  [00:21:20] Ana Lisa: If you just had one genome, you could never have made this novel discovery. I think the other thing is that, and Nicky will say that, you know, she, she then contacted her collaborators who also had access to, to, to data that had been shared by other families and could compare. And again, it's a whole sort of network across the globe.  [00:21:41] Ana Lisa: And we know that there are going to be many more diagnoses to be found. But also, um, I think collaboration will allow us to find new, new treatments. So if we can start to design treatments that target the DNA and RNA at, at source, then actually you could collaborate and say, "Well, this type of genetic mechanism could be targeted in the same way, potentially across even more than one rare condition and reach even more patients."  [00:22:13] Ana Lisa: And actually the power of collaboration across the ecosystem is that hopefully we'll end up with a pathway that can actually go from finding a new genetic finding, like Nicky and her team made, to helping all the people who could benefit from a diagnosis, having one, and then can one develop a treatment and get it to as many patients?  [00:22:42] Ana Lisa: And, and I think that will really demonstrate the power of collaboration.   [00:22:47] Sharon: Yeah. Absolutely, and it can only, you know, benefit those families who have to wait such a incredible amount of time.   [00:22:55] Ana Lisa: There's been such a diagnostic odyssey, and as more diagnoses are made, it becomes obvious that there's, uh...  [00:23:03] Ana Lisa: and it was, it's already well-described, the therapeutic odyssey. Um, but hopefully these sort of novel understanding of our genome and opening up new biological avenues to treat, um, hopefully will also enable many more new treatments to be developed.   [00:23:21] Sharon: Absolutely, and that is the key word there is, is that hope.  [00:23:24] Sharon: So, so looking ahead, Nicky, what developments are you most hopeful about over the next few years?   [00:23:31] Nicky: That's a difficult question. There's so much, so much happening. One thing is that we are gearing up to do large scale studies across the world to understand more about the progression of ReNU. So you might call them large scale natural history studies or just large scale profiling studies where we can do a range of different tests on ReNU patients and, and monitor them over time.  [00:24:02] Nicky: So do those at regular, regular intervals over time so we can see what the progression looks like. And that's really important for trying to think about whether we can treat RNeU syndrome. And on that note, I'm very also excited about the potential for therapeutics. There's lots of people all around the world, both, uh, in academic settings, but also in pharma companies trying to work out whether this is something that we can treat.  [00:24:30] Nicky: There's some very promising early data to show that we can selectively remove the RNA containing the mutation from cells, uh, leaving the copy of the RNA that doesn't contain the mutation intact so that can do the correct function. And biologically, we think this should be an effective treatment.  [00:24:54] Nicky: Um, so we can do that in cells in a dish. We don't yet know whether we can do that in a patient with ReNU. Uh, but that's really, really promising early data. Um, so I'm very hopeful about where that, those studies might lead.   [00:25:08] Sharon: And Ana Lisa, what role will genomics continue to play in improving understanding and care for rare conditions like this?  [00:25:15] Ana Lisa: So following on from what Nicky said, I think the really big hope is that we will be able to develop many, many new treatments collaboratively across the world. And whether these are individualised treatments made for one patient but then shared because we can find perhaps other patients who could benefit from the same treatment, whether we understand the genetics better so that we can design treatments from the start that will work for a lot of patients.  [00:25:46] Ana Lisa: So I think there will be sort of fancier and fancier ways of targeting rare conditions. And right now we're in a phase where the ecosystem is trying to work out how could we make an end-to-end pathway with initiatives like the Rare Therapies Launchpad in the UK, and that's going to require truly collaborative working.  [00:26:08] Ana Lisa: No single organisation can do that. And I think having these incredible use cases will be really powerful for turbocharging the development of these pathways. And the hope is that once you've worked out how to do this across a range of different rare conditions, that one might reach a stage where one could do that a lot faster for many other rare conditions.  [00:26:35] Ana Lisa: Because at the moment they're so underserved in terms of treatments available and there's a huge gap between being able to make a genetic diagnosis and then having treatments. The big hope is that understanding the genetics better will help to open up new pathways to treatment. I do hope that we'll also understand other aspects.  [00:27:02] Ana Lisa: So for example, it might be that understanding the genetics better also helps us to understand different ways a condition might manifest in somebody, why it may be different from one person to another, why somebody might be more mildly affected and somebody perhaps more severely. And that might, may also help us to understand ways to treat a condition by getting, gaining these insights which are, are useful in and of themselves and may also lead to new therapeutic, uh, possibilities.  [00:27:36] Ana Lisa: I think that would be one of my hopes that a lot of these areas overlap and lead to real benefit for patients and families, that we can translate that hope into concrete improvements in treatment for rare conditions.  [00:27:57] Sharon: Do you have a sense of time, how long you think this could all take, that amount of collaboration?  [00:28:06] Ana Lisa: Yeah, and I think this is actually another reason why sometimes it's quite tricky to make progress in this area because being able to predict those timelines is notoriously difficult when you look back historically. I'd like to hope that we're on the cusp of having an explosion of novel treatments that can target DNA and RNA, for example, or treatments that target something in the underlying biology that we now understand that we didn't before.  [00:28:34] Ana Lisa: And I do think that there is going to be a big shift. But I think that the sort of confidence intervals around how big that range of time might be is very hard to predict. And that's why I think Christina and Nicky being able to share these stories and about their collaborative working really shines a spotlight on, on what could be done and how progress can happen.  [00:29:02] Ana Lisa: That's really exciting. The other day at a conference, someone from industry stood up and said, "Oh, actually, we set up a clinical trial in the UK because we knew there were patients who could benefit from our work in the National Genomic Research Library," and that was really exciting for us because that's what we want to do; move forwards the opportunities for treatment for patients.  [00:29:28] Sharon: And so finally, Christina, as a parent and member of this community, what are your hopes for the future, and what would you say to families who may still be searching for answers today?   [00:29:39] Christina: It is a long journey, but there is the support and the help out there. If you have any inclination that you think you might have ReNU, reach out to your paediatrician or your doctor to see if you can get your genetic testing done because it's fighting to get the test, to go to people and say, "I think this is what we may have. Can we look into getting it tested?" And reach out to other families and the website and things because it's all about community and supporting and helping people find that diagnosis.   [00:30:16] Sharon: Thank you, Christina, and we'll put the website in the episode description. A huge thank you to Professor Nicky Whiffin, Christina Cox, and Dr. Ana Lisa Tavares for joining me today and sharing their insights and experiences. To learn more about ReNU Syndrome, visit renusyndromeuk.org. If you'd like to hear more stories about the people, research, and discoveries helping to shape the future of healthcare, subscribe to Behind the Genes on your favourite podcast app.  [00:30:45] Sharon: Thank you for listening. I've been your host, Sharon Jones. Behind the Genes is produced by Deanna Barac, Florence Cornish, Sophie McLachlan, and Katie Revell at Bespoken Media. 

Listen to the Jay Garvens Home & Mortgage Show on KRDO News Radio 105.5FM & 1240AM at 8am this morning as Jay tells you about the “Presidential libraries – Abilene Kansas & Fly Over states! ... The post PRESIDENTIAL LIBRARIES – ABILENE KANSAS & FLY OVER STATES – 7-25-26 appeared first on Jay Garvens.

Francesca Paris, reporter for The Upshot section of The New York Times, talks about why some states have rolled back incentives that unlock savings for residential solar customers and how batteries may be the solution. Photo: Modern house with solar panels for energy storage. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We asked you about traveling to all 50 states, and in response got several stories about interesting quests and journeys across the U.S. Up Next: Tell us your stories about visiting the U.S National Parks. Which ones have you been to? Which ones are you looking forward to? Did everything go as planned? Did anything surprising happen? Tell us all about it. Give us a call at 315-992-7902 and leave a message with your story and your name. You can also record a voice memo and email it to us at Hello@AtlasObscura.com.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Reason eleventy billion we need to pass the SAVE America Act, acting DNI Bill Pulte drops eye watering news about the voter rolls in more than a dozen states being compromised by the CCP. So... China IS controlling US elections....? Investigative reporter Catherine Herridge drops a sit-down with a former senior CIA official turned whistleblower and what he says about Covid and Fauci's handling of it will captivate you.  

The Dean's List with Host Dean Bowen – Both males argued that the law should not apply to them since they had no biological advantage over girls because they were taking female hormones and/or puberty blockers. “States and leading athletic organizations disagree with the plaintiffs and have concluded that biological males still retain a physical advantage after taking puberty blockers and hormones...

In this second episode of the "Back to Basics" series, we explore the six nervous system states and how understanding them can transform your approach to anxiety and depression healing.CLICK HERE for the full show notes, resources, and 3 tangible takeaways!—Ps. This is a re-run of this series.  It originally aired in February 2025, and is still the series I hear back about the most. Since there's been a wave of new listeners joining lately, I wanted to bring it back around.And for those of you who were here the first time, I invite you to listen again through the lens of where you are right now, it's likely shifted over the last year and a half, and just see what lands differently.—Looking for more personalized support? 1:1 Coaching (RESTORE):  Learn more or book a free discovery call (HSA/FSA eligible & includes comprehensive bloodwork)Regulated Living Membership:  A mental health membership and nervous system healing space (sliding scale pricing available). Join here.Order my book: Healing Through the Vagus Nerve*Want me to talk about something specific on the podcast? Let me know HERE.Website: https://www.regulatedliving.com/podcastEmail: amanda@regulatedliving.comInstagram: @amandaontheriseTikTok: https://www.tiktok.com/@amandaontherise

Spadoni and Shasky, plus pinch hitter Lubman, discuss the injury to Casey Schmitt and how it will effect the Giants. Training camp has opened for the 49ers, the guys discuss the outlook on the season. Plus, Draymond Green shares his thoughts on why LeBron didn't come to the Warriors.

In this episode, NSVRC's Evaluation Coordinator, Sally Laskey, and Prevention Coordinator, Mo Lewis, discuss economic supports as a method for preventing sexual violence   Show Notes: In this episode, NSVRC's Evaluation Coordinator, Sally Laskey, and Prevention Coordinator, Mo Lewis, discuss economic supports as an important aspect of sexual violence prevention. Participants · Sally Laskey, Evaluation Coordinator · Mo Lewis, Prevention Coordinator Sexual Violence Prevention Resource for Action (CDC) https://www.cdc.gov/violence-prevention/media/pdf/resources-for-action/SV-Prevention-Resource_508.pdf   Risk and Protective Factors Infographic (NSVRC) https://www.nsvrc.org/resource/risk-and-protective-factors/   Over 8.3 million workers will benefit from minimum wage increases on January 1 (Economic Policy Institute Blog) https://www.epi.org/blog/over-8-3-million- workers-will-benefit-from-minimum-wage-increases-on-january-1-nineteen-qstates-will-raise-their-minimum-wages-heres-where/   States of Affordability: A series on where and why US households struggle to make ends meet (Brookings Institute) https://www.brookings.edu/articles/states-of-affordability-a-series-on-where-and-why-us-households-struggle-to-make-ends-meet/ Pay Range Transparency Helps Reduce Gender Wage Gaps (National Women's Law Center) https://nwlc.org/wp-content/uploads/2023/01/NWLC-Pay-Range-Transparency-Factsheet_2023-1.pdf   Paid Family Leave: A Promising Strategy for IPV Prevention (Center for Policy Research) https://www.preventn.com/_files/ugd/40dfdf_dfd23756db7d4b14808ff2ed326a2e60.pdf   The Top 10 Things Unions Can Do In The Workplace To Address Sexual Harassment (Futures Without Violence) https://futureswithoutviolence.org/wp-content/uploads/2025/03/2025_The-Top-10-Things-Unions-Can-Do-In-The-Workplace-To-Address-Sexual-Harassment.pdf Messaging the Connections: Explaining the links between strengthening economic supports and preventing sexual and intimate partner violence (PreventConnect Webinar) https://www.preventconnect.org/2020/07/messaging-the-connections-explaining-the-links-between-strengthening-economic-supports-and-preventing-sexual-and-intimate-partner-violence/ Prevention Messaging Best Practices (NSVRC) https://www.nsvrc.org/resource/prevention-messaging-best-practices/

States are sitting on billions in unclaimed money. There's a free site to check if some of that belongs to you. Who knows? You could be like Steph. She found $1,200 the same way. Learn more about your ad choices. Visit megaphone.fm/adchoices

In recent weeks, we've seen our skies engulfed in dystopian haze. We've had lethal heat waves ruin our Fourth of July cookouts. States have announced emergency water rationing due to record-breaking droughts. Tens of thousands of Europeans have been killed by extreme heat so far this summer; hundreds of thousands are being evacuated by apocalyptic wildfires. And we know it's just the beginning—this is, after all, not just the hottest summer of our lives, but the coolest summer for the rest of our lives.This didn't just happen. Climate change is overwhelmingly the result of pollution and deception from specific Big Oil companies that were predicting decades ago that their fossil fuels would cause, in their own words, “globally catastrophic” climate harms that would create “more violent weather” and cause “suffering and death due to thermal extremes.” Even as they used this knowledge to protect their own infrastructure, they orchestrated fraudulent campaigns of climate denial to lock us into the disasters we are currently experiencing.But we're not powerless in the face of these nightmares. We can take on Big Oil, and the fossil-fueled authoritarianism that these corporations have done so much to engender. And there are few people with more experience in these fights than Jamie Henn, director of Fossil Free Media. He joined us for a great conversation about making polluters pay, the ways clean energy developments have totally transformed the climate fight, and how to balance hope and fear in the midsts of climate chaos.Fighting Fascism Podcast is produced by Nik Damants in collaboration with The Nation.Intro song and music by Horse Radish.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

I further examine the strategic deficit disorder that absolutely dominates the US and western military establishments. America has a singular inability to execute large and complex wars without failing in a spectacular fashion. I speak to the tools and critical thinking modalities that could spark and encourage competent martial imagination. Moral courage is necessary to tell the flag officer dullards and their Senior Executive Service (SES) necromancers that the emperor has no clothes. Recommended Listening: On Strategic Empathy Recommended Reading: Michael Mazarr Leap of Faith: Hubris, Negligence, and America’s Greatest Foreign Policy Tragedy Williamson Murray The Making of Strategy: Rulers, States, and War Frans Osinga Science, Strategy and War (Strategy and History) Stephen Robinson The Blind Strategist: John Boyd and the American Art of War Christian Madsbjerg Sensemaking: The Power of the Humanities in the Age of the Algorithm Johnson and Abbe Developing Strategic Empathy and Perspective Taking in Military Zachary Shore A Sense of the Enemy: The High Stakes History of Reading Your Rival’s Mind Dave Snowden Cynefin – Weaving Sense-Making into the Fabric of Our World US Army Center of Military History My Substack Email at cgpodcast@pm.me

Michael Germi is a former Muslim born in Iran into a Shia Muslim family. In this setting he learned to practice Islam praying 5 times a day toward Mecca. He fasted during Ramadan. He practiced self-mutilation for the cause of Allah. He migrated to Australia in 2006 and in 2009 placed his trust in Jesus Christ. He later moved to the States where he is a missionary with Baptist World Mission and now proclaims the Gospel to Islamic nations by satellite TV, satellite radio and internet radio. He has written several Farsi Christian books and desires to plant churches around the world where Persians are scattered. After 13 days of strikes, the United States has paused its military actions against Iran hoping for diplomacy to take place. The U.S. Ambassador to the United Nations, Mike Walz said yesterday that the President was "giving talks some space, he's giving a little bit of room." A senior official in the Trump administration said that the President "has always been clear that his preference is diplomacy, but he has shown Iran what will happen if they fail to come to the table in a serious way." Today Iran says it is still in control of the Strait of Hormuz and is not seeking to resume peace talks with the United States. As a matter of fact, a spokesperson for Iran's Foreign Ministry, Esmail Baghaei said Iran has not asked to resume peace talks with the United States. Last week wng.org reported that "Iran's Ministry of Intelligence recently classified several Persian-language Christian satellite TV broadcasters as hostile organizations." Such Christian broadcasters were being banned alongside other groups such as Voice of America, BBC Persian and Israeli outlets. "Iran

Host Amanda Bauner continues the celebration of the 50 U.S. states, focusing on the South and West regions. She shares fun facts and top activities for each state, from Kentucky to Hawaii, blending her own travel experiences with community contributions. Listeners get recommendations for iconic landmarks, scenic destinations, unique events, and hidden gems across the country. Episode Resources National Geographic book: "50 States 5000 Ideas". HGTV article: "50 States of Free Fun: Museums, Gardens, Parks and More" by Lauren Oster, June 23, 2026. Join the Me and the Magic Community Join the Me and the Magic Facebook community to share your love of solo travel, Disney travel, and more with new friends. Plus, share your thoughts and questions on this episode with the community! Connect with Amanda Is there a topic you'd like us to discuss? Email Amanda at amanda@meandthemagic.com.   Subscribe to the Me and the Magic weekly newsletter for exclusive content, including solo travel tips! Me and the Magic has voicemail! Leave a voicemail or text to 1-347-74MAGIC (1-347-746-2442). Share your thoughts about this episode, a future episode topic idea, or just say hi! Podcast Subscribe to this podcast so you will be the first to hear new episodes!  If you are enjoying the podcast, I'd greatly appreciate it if you could rate and review it on Apple Podcasts. The reviews help other people find this podcast.  Online Shop Buy some fun travel and pop culture shirts and more, at our online shop! 

My guest today is the Season 15 winner of America's Got Talent, a 7x Telly Award Winner, 1x SOVAS Award Winner, and 1x Emmy Award Winner, the one and only Brandon Leake. He has been a Poetic Performer, Keynote Speaker, and Workshop leader for over a decade, traveling worldwide and 42 States. Brandon has collaborated with companies such as Meta, CBS, California Hospital Association, Good Morning America, Golden State Warriors, Sacramento Kings, and many others. Brandon's use of personal narrative with his gifting in poetic prose allows him to speak not merely to crowds, but to their inner being, to connect one soul to another, to connect people to an intrinsic sense of communal humanity that is at times severely lacking in our world. Brandon Leake is a visionary, whose words, but most importantly actions reflect his love of Christ, people, and the world. #americagottalent #brandonleake #poet #spokenword #artist #inspiration #faith #jesus #encouragement

This week on Gun For Hire Radio… 2A Attorney Dan Schmutter joins us for a rundown of the lowdown on standard capacity magazines, “evil features” and what we can or cannot expect the States response to be as the clock ticks and the end is near for the New Jersey Gun control regime. What tricks, traps, fees, registration, work arounds, delays, etc, etc. are awaiting we, the law abiding tax paying citizens as they stomp their feet in a 2A Tantrum! Because after being in this fight for the past 34 years I know NOTHING is beneath them! Tune in to find out. The post The Gun For Hire Radio Broadcast: Episode 792 appeared first on Best Gun Range NYC and NJ Area | Gun Range Near Me.

Artificial Sweeteners & Cognitive Decline, Myosteatosis on Coronary CT, Merck's Oral PCSK9 Inhibitor, Cyclospora Outbreak, Gut-Brain Synchronization, and the Banana Smoothie Mistake Explained Artificial Sweeteners Linked To 62% Faster Cognitive Decline In Landmark Brazilian Study A study tracking more than 12,700 adults (average age 52) over eight years found that people consuming the most artificial and low-calorie sweeteners, roughly 191 mg a day, about what's in a single can of diet soda, showed cognitive decline 62% faster than the lowest-intake group, equivalent to 1.6 extra years of brain aging, with memory hit hardest. Six of the seven sweeteners tested, including aspartame, saccharin, and acesulfame K, were linked to faster decline; tagatose was the lone exception. Researchers point to gut-microbiome disruption, altered glucose and insulin signaling, and possible direct neuronal effects as plausible mechanisms. Host Dave Asprey breaks down why a dose this small was enough to move the curve, why tagatose deserves more scrutiny before being called "safe," and where diet products' short-term weight-loss marketing conveniently ignores the long-term cost to your brain. Source: https://www.inc.com/kevin-haynes/study-links-cognitive-decline-to-surprisingly-small-daily-amount-of-artificial-sweeteners/91376522 ~~ AI Analysis Of 1,722 Heart Scans Finds Muscle Quality Predicts Heart Attacks Independent Of Calcium Score Using data from the SCOT-HEART trial, a University of Edinburgh team ran an AI model against ten years of coronary CT angiogram scans, measuring skeletal muscle attenuation, a marker of myosteatosis, or fat infiltration into muscle tissue. Every 10-point increase in muscle density corresponded to a 31% lower heart attack risk and 39% lower all-cause mortality over the following decade, and critically, this held independent of coronary calcium score, the current gold-standard risk marker. The same low-density-muscle patients also showed higher lung attenuation, lower liver attenuation, and more torso fat volume, a pattern consistent with systemic insulin resistance rather than a muscle-specific issue. Host Dave Asprey unpacks why calcium score isn't capturing the full risk picture, why myosteatosis is really a readout of whole-body insulin sensitivity, and what he'd add to a routine workup on top of a calcium score. Source: https://www.theguardian.com/science/2026/jun/30/strong-chest-back-less-likely-heart-attack-analysis ~~ FDA Approves First Oral PCSK9 Inhibitor, Cutting LDL By Up To 60% Without Injections Merck's enlicitide (brand name Lipfendra) is now FDA-approved as the first once-daily oral PCSK9 inhibitor, lowering LDL cholesterol by up to 60% in a phase 3 trial of 2,912 patients, routinely bringing levels down to 50-60 mg/dL. It works by blocking PCSK9, a liver protein that tags LDL receptors for destruction, the same target as injectable drugs like Repatha and Praluent, which have shown roughly 20% reductions in heart attacks and strokes in high-risk patients. Lipfendra is priced at $315 for a 30-day supply, with no excess side effects reported versus placebo over six months, though long-term outcome data is still pending. Host Dave Asprey explains why crushing total LDL without checking ApoB, LDL particle number, or oxidized LDL is optimizing the wrong variable, and what he'd want on his labs before considering a drug like this. Sources: https://www.nytimes.com/2026/07/16/science/the-fda-approves-a-new-pill-to-slash-cholesterol-levels.html https://www.cnbc.com/2026/07/16/mercks-cholesterol-pill-gets-us-fda-approval.html ~~ Cyclospora Outbreak Tied To Taylor Farms Lettuce Spreads To 34 States, Prompts Nationwide Recall Federal investigators have linked a multistate cyclosporiasis outbreak to shredded iceberg lettuce from Taylor Farms de Mexico, with Michigan alone logging over 5,000 cases and 100+ hospitalizations, much of it traced to lettuce used at Taco Bell. Taylor Farms has recalled all iceberg lettuce sourced from central Mexico, and Walmart has pulled Marketside Iceberg Salad and Marketside Shredded Lettuce with specific date codes across 27 states. Cyclospora spreads through fecal contamination and causes weeks of watery, explosive diarrhea if untreated; washing doesn't reliably eliminate it, since the parasite requires heat above 158°F to inactivate. Host Dave Asprey explains why pre-washed, pre-cut bagged greens remain a recurring contamination risk no matter what the label claims, and connects the outbreak's gut damage to lingering gut-brain consequences long after symptoms resolve. Sources: https://www.usatoday.com/story/news/health/2026/07/18/taylor-farms-shredded-lettuce-sample-cyclospora/90969103007/ https://www.fda.gov/food/outbreaks-foodborne-illness/investigation-5-state-outbreak-cyclospora-illnesses-iceberg-lettuce-july-2026 ~~ New Research Links Excessive Gut-Brain Synchronization To Anxiety And Depression Emerging research on the enteric nervous system, which contains over 100 million neurons and sends more signals to the brain than it receives, finds that when the gut's electrical rhythm synchronizes too tightly with the brain's, that over-coupling correlates with higher rates of anxiety and depression. The gut communicates with the brain through the vagus nerve, hormones, and immune signaling, and dysbiosis or ENS dysfunction has separately been linked to mood disorders in both human and animal studies. Host Dave Asprey breaks down why the goal isn't maximum gut-brain connection but the right kind of connection, questions whether the coupling is driving the anxiety or the anxiety is driving the coupling, and makes the case for treating mood from the gut up instead of the brain down. Source: https://refractor.io/medical/enteric-nervous-system-brain-link-mental-health/ ~~ Rhonda Patrick Explains Why She Never Adds Bananas To Her Berry Smoothies Rhonda Patrick has been telling audiences she skips bananas in her berry smoothies because of polyphenol oxidase, an enzyme in bananas that degrades the polyphenols in blueberries linked to improved cognition and vascular health, based on in-vitro and food chemistry data. She now builds her smoothies on an avocado base instead, and notes that vitamin C from citrus can partially inhibit the enzyme for anyone unwilling to drop the banana. Host Dave Asprey weighs in on the gap between lab chemistry and clinical outcome data, why that gap doesn't make the mechanism any less real, and why this is a low-cost swap worth making even without a human trial behind it. Sources: https://www.reddit.com/r/Biohackers/comments/1v2jbib/dr_rhonda_patrick_i_dont_add_bananas_to_my/ https://www.foundmyfitness.com/episodes/polyphenol-oxidase-bananas-smoothies ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insight into a sweetener risk hiding in everyday diet products, a heart attack predictor buried inside routine CT scans, the tradeoffs of a new cholesterol drug, a produce recall worth paying attention to, the science behind gut-driven anxiety, and a smoothie mistake that's quietly undercutting your polyphenol intake. Host Dave Asprey connects clinical research, cohort data, and food chemistry into practical frameworks for protecting brain health, cardiovascular health, and gut-brain resilience. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: artificial sweeteners cognitive decline, aspartame brain aging, tagatose safety, diet soda memory loss, myosteatosis coronary CT, skeletal muscle attenuation heart attack, SCOT-HEART trial, coronary calcium score insulin resistance, enlicitide Lipfendra FDA approval, oral PCSK9 inhibitor, LDL particle number ApoB, cyclospora outbreak 2026, Taylor Farms lettuce recall, cyclosporiasis symptoms treatment, enteric nervous system anxiety, gut brain synchronization, vagus nerve mental health, Rhonda Patrick polyphenol oxidase, banana blueberry smoothie mistake, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com. - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:19 – Story 1: Artificial Sweeteners 02:05 – Story 2: Muscle Fat & Heart Risk 04:36 – Story 3: PCSK9 Cholesterol Pill 06:27 – Story 4: Cyclospora Lettuce Outbreak 07:56 – Story 5; Gut-Brain Axis & Anxiety 09:29 – Story 6: Banana vs. Blueberry 11:08 – Predictions for Next 5 Years See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, my guest is Dr. Sam Harris, PhD, a neuroscientist, bestselling author, and world-renowned meditation teacher whose work focuses on consciousness, ethics, and religion. We discuss how meditation can help us better understand the nature of the self and transform the conscious experience. Sam also explains how meditation can help overcome universal challenges such as distractibility, mental chatter and emotional reactivity, which can allow for greater focus and fulfillment in the present moment. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman Timestamps (00:00:00) Sam Harris (00:00:21) Sense of Self, Meditation Purpose; Flow (00:08:37) Sponsor: Eight Sleep (00:09:55) Self Awareness, Self-Talk & Mental Chatter (00:14:44) Mindfulness, Distractibility (00:19:55) Sponsor: Waking Up (00:21:30) Meditation, Benefits, "Sky-like Mind"; States of Self (00:27:33) Meditation Practice, Mindfulness & Freedom (00:30:17) Psychedelics, Consciousness (00:34:15) Sponsor: AG1 (00:35:34) Process vs Achieving Goals, Fulfillment in Present Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices