Podcast appearances and mentions of robert schooley

Welcome back! Today we're excited to be joined by Dr. Robert Schooley, an individual who many of you may recognize in the coming years as a leading pioneer in the development of bacteriophage medicine. His prior work includes and is far from limited to Co-Director of the Center for Innovative Phage Applications and Therapeutics at UCSD, head of NIAID's AIDS Clinical Trials team which produced many of the antiretrovirals still in use for HIV/AIDS, as well as Editor of the Journal of Clinical Infectious diseases. Our conversation covered the history of bacteriophages, their unique clinical utility as an efficient alternative to antibiotics, and their potential in a world with antibiotic resistance that threatens much of the progress of the last century.

As we sit here in 2020, in the middle of a major viral pandemic, we can't forget the fact that a century after the first antibiotics were created, drug resistant bacterial infections have become a major threat around the globe, exactly at the same time that the antibiotic pipelines of pharma companies have either dried up, or they have gotten out of the business. In the U.S. alone, Centers For Disease Control (CDC) estimates that antibiotic resistance causes more than 2 million infections, several million hospital stay days, and over 35,000 deaths per year. Worldwide, such infections cause 750,000 deaths every year. And a recent United Nations (UN) report concluded that by 2050, "super bugs" could kill 10 million people globally every year, if no action is taken to combat the problem. A solution to this emerging threat lies in the area of bacteriophage therapy (or "phage" for short), which is a type of virus that infects, replicates within, and are very good at killing bacteria. Interestingly, phages have been used for over 90 years as an alternative to antibiotics in the former Soviet Union and Central Europe as well as in France. They are seen as a possible therapy against multi-drug-resistant strains of many bacteria and have been shown to interfere not just with bacteria life cycles, but also with biofilm production and quorum sensing involved bacterial colonization processes. Dr. Robert Schooley, MD, is a Professor of Medicine, in the Division of Infectious Diseases and Global Public Health, at UC San Diego, the Co-Director of their Center for Innovative Phage Applications and Therapeutics (IPATH), as well as Interim Faculty Director, Global Education and Senior Director, International Initiatives. Dr. Schooley is a graduate of the Johns Hopkins University School of Medicine. He completed an internal medicine residency at the Johns Hopkins Hospital and infectious disease fellowships at the National Institute of Allergy and Infectious Diseases and the Massachusetts General Hospital. He joined the faculty of Harvard Medical School in 1981 and shifted his research focus from herpes group viruses as recognition of the AIDS epidemic developed. Dr. Schooley was then recruited to the University of Colorado in 1990 as Head of the Division of Infectious Diseases where he developed an integrated HIV program clinical care and research program. He was elected Chair of the NIH's AIDS Clinical Trials Group (ACTG) in 1995 and led that group until 2002 during which time the ACTG performed many of the seminal studies that defined modern anti-retroviral chemotherapy. Dr. Schooley led the ACTG in its expansion from a domestic US research operation into one with a global reach with research units in Africa, India, Thailand, Haiti and Latin America. In 2005, he joined the faculty at the University of California San Diego where he served as Head of the Division of Infectious Diseases until 2017. He also serves as Editor-in-Chief of Clinical Infectious Diseases. His research interests are in the diagnosis, pathogenesis and therapy of viral infections and in global health. 

Why weren't we ready? There are so many conflicting theories surrounding this idea that it seems hard to answer. But it is not a black box, there is a science to this. In fact, we have been through outbreaks so many times that our lacking response is shocking. To learn more about the history of infectious disease and why we weren't ready I decided to talk to an expert. Dr. Robert Schooley is one of a handful of true infectious disease experts. He has seen numerous outbreaks and spent his entire career in research and treatment of infectious disease. Dr. Schooley and I spoke about the historic lack of resources for the study infectious disease, where we went wrong in this pandemic, and what the path to "normalization" must look like to avoid a relapse.

Why weren't we ready? There are so many conflicting theories surrounding this idea that it seems hard to answer. But it is not a black box, there is a science to this. In fact, we have been through outbreaks so many times that our lacking response is shocking. To learn more about the history of infectious disease and why we weren't ready I decided to talk to an expert. Dr. Robert Schooley is one of a handful of true infectious disease experts. He has seen numerous outbreaks and spent his entire career in research and treatment of infectious disease. Dr. Schooley and I spoke about the historic lack of resources for the study infectious disease, where we went wrong in this pandemic, and what the path to "normalization" must look like to avoid a relapse.

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

Over the past two decades novel coronaviruses have spilled from the bat to the human population on three occasions. The first two breakouts in south China in 2003 and in Saudi Arabia in 2012 launched the SARS and MERS outbreaks, respectively. Both outbreaks were contained by aggressive case finding, contact tracing and quarantine activities. A third crossover of a novel coronavirus into the human population occurred in the fall of 2019. This event which is believed to have occurred around a wet market in Wuhan, China was unfortunately not efficiently contained and spread rapidly across China. Since its crossover events six months ago, the virus has infected over 4 million people and resulted in 300,000 deaths. This presentation by Dr. Chip Schooley, UC San Diego Professor of Medicine, focuses on the biology, pathogenesis and epidemiology of the SARS-2 coronavirus and containment efforts to date. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Science] [Show ID: 35846]

While on a bucket list trip to Egypt, Steffanie Strathdee's husband Tom Patterson fell ill with what they first assumed to be food poisoning. They soon discovered it was much more serious. Tom was diagnosed with pancreatitis and gallstones. The gallstones had blocked his biliary duct, which had caused an abscess the size of a small football to form in his abdomen. When the fluid inside the abscess was cultured, doctors found the “worst bacteria on the planet,” Acinetobacter baumannii. This bacteria, nicknamed Iraqibacter due to the veterans who have returned from the middle east with the superbug, is an organism that is very prone to acquiring antimicrobial resistance genes from other bacteria. Tom was very ill. With the combination of pancreatitis and the superbug, his chance of survival was no more than 10%. Acinetobacter baumannii was only partially sensitive to three known antibiotics, and those were considered to be last chance therapies. He was treated with those drugs, but his bacteria resisted all of them. Steffanie is an infectious disease epidemiologist, but felt blindsided by Tom's diagnosis. Luckily, she had the right combination of knowledge, access to research, and willing medical and research professionals to try alternative therapies. Her research led her to phage therapy. Bacteriophage therapy (phage therapy, for short), are viruses that have naturally evolved to attack bacteria. The perfect predator, they have been co-evolving with bacteria for 4 billion years. There are more than 10 million trillion trillion phages on earth and they are everywhere: in water, soil, and our bodies. Phage therapy has been a known treatment against bacteria for decades, but has been practiced more in the former Soviet Union since western countries started relying on penicillin and other antibiotics since the 1940's. The challenge is to find the particular phage that is effective against the bacterial infection being treated. You are going to love this story of love, determination, resourcefulness and triumph. Steffanie cured Tom's illness with the help of three universities, the US Navy and researchers from across the world. What she discovered in the process is a super weapon against multidrug antimicrobial resistant diseases, which are expected to kill more than ten million people per year by 2050.   Links and notes: Steffanie Strathdee and Robert Schooley are co-directors of the Center for Innovative Phage Applications and Therapeutics (“IPATH”) at UC San Diego Donate to IPATH here Steffanie Strathdee and Tom Patterson's book about their ordeal is called The Perfect Predator Learn more about The Infection Prevention Strategy at ic.tips If you liked this podcast, please consider subscribing to the series and leaving a positive review

Ahh social media, the place where you see pics of people's brunch and discover hilarious voices. Twitter is where I discovered TV Writer Robert Schooley. I knew I needed to talk to the guy who tweets golden nuggets of political humor on the daily. Robert may have missed his calling in the FBI. In an epic investigatory feat that made headlines, Robert busted Trump on retweeting bots. Robert also shares the tweet that almost got him in hot water in Hollywood and why he thinks Trump looks like a Muppet. Listen in to Robert's first ever podcast interview and then seriously go and follow this guy, he's hilarious!! See acast.com/privacy for privacy and opt-out information.

In this interview from the Outbreak News This Week Radio Show in May 2017, we looked at this amazing story of an individual with a multi-drug resistant Acinetobacter baumannii infection and the use of an experimental therapy involving bacteriophages — viruses that target and consume specific strains of bacteria. Case study lead author and the primary physician of the patient, Professor of Medicine and Chief of the Division of Infectious Diseases at the UC San Diego School of Medicine, Robert Schooley,MD joined me to share the details of the remarkable story.