Podcasts about Harvard Medical School

Hey Heal Squad! If you've been confused, overwhelmed, or just a little skeptical about everything you're hearing about GLP-1 medications right now, ya might want to listen to this one! Today Maria sits down with Dr. Fatima Cody Stanford. She is an Associate Professor of Medicine at Harvard Medical School and Massachusetts General Hospital, and one of fewer than 15 physicians in the entire country who has completed more than one year of fellowship training specifically in obesity medicine. Maria first met Dr. Fatima at a Patriots game in Boston, and what struck her wasn't just the credentials,  it was how differently she talked about weight, the human body, and the people she treats. Literally, this became a true eye-opening science conversation about the GLP-1 space. Dr. Fatima breaks down what a GLP-1 actually is, why fat is literally an organ in the body, how our brains regulate weight through specific biological pathways, and why genetics, circadian rhythm, trauma, and environment all play a role in why some people's bodies hold onto weight no matter what they do. Then the conversation took a turn that genuinely surprised us. Dr. Fatima reveals that GLP-1 receptors exist throughout the entire body (not just in the gut, like most of us think!). which is why these medications are already being approved for conditions far beyond weight loss. Take a listen, it's a great conversation before you form any opinion. Enjoy! HEALERS & HEAL LINERS GLP-1s Are Not a Trend — They're a 20-Year Story: Dr. Fatima explains why they've been in development and clinical use for over two decades, and why the reason we're hearing about them now comes down to one thing — potency. The science didn't change. The strength finally caught up. Obesity Is a Disease, Not a Decision: One of the most powerful moments in this episode is when Dr. Fatima dismantles the idea that weight is simply about discipline. From genetics and brain signaling to circadian rhythm disruption and weight-promoting medications, she lays out the real biology behind why people carry excess weight. Your Body Is Fighting Back — On Purpose: Physical activity helps you maintain your weight, but it does not help you drop it. She explains exactly why the body defends its set point and what it actually takes to change it. Join us at our Canyon Ranch 2026 Retreat: https://www.canyonranch.com/lenox/retreats/heal-retreat-maria-menounos HEAL SQUAD SOCIALS IG: https://www.instagram.com/healsquad/ TikTok: https://www.tiktok.com/@healsquadxmaria HEAL SQUAD RESOURCES: Heal Squad Website:https://www.healsquad.com/ Heal Squad x Patreon: https://www.patreon.com/HealSquad/membership Maria Menounos Website: https://www.mariamenounos.com My Curated Macy's Page: https://stylecrew.macys.com/@mariamenounos EMR-Tek Red Light: https://emr-tek.com/discount/Maria30 for 30% off Airbnb: https://www.airbnb.com/host GUEST RESOURCES: Follow Dr. Fatima on Instagram: https://www.instagram.com/askdrfatima/?hl=en More info on Dr Fatima here: https://askdrfatima.com/ ABOUT MARIA MENOUNOS: Emmy Award-winning journalist, TV personality, actress, 2x NYT best-selling author, former pro-wrestler and brain tumor survivor, Maria Menounos' passion is to see others heal and to get better in all areas of life. ABOUT HEAL SQUAD x MARIA MENOUNOS: A daily digital talk-show that brings you the world's leading healers, experts, and celebrities to share groundbreaking secrets and tips to getting better in all areas of life. DISCLAIMER: This Podcast and all related content (published or distributed by or on behalf of Maria Menounos or http://Mariamenounos.com and http://healsquad.com) is for informational purposes only and may include information that is general in nature and that is not specific to you. Any information or opinions provided by guest experts or hosts featured within website or on Company's Podcast are their own; not those of Maria Menounos or the Company. Accordingly, Maria Menounos and the Company cannot be responsible for any results or consequences or actions you may take based on such information or opinions. This podcast is presented for exploratory purposes only. Published content is not intended to be used for preventing, diagnosing, or treating a specific illness. If you have, or suspect you may have, a health-care emergency, please contact a qualified health care professional for treatment.

In a panel discussion hosted by the Sadhguru Center for a Conscious Planet and moderated by Matcheri Keshavan (Professor, Harvard Medical School), Sadhguru, Swami Sarvapriyananda (Minister & Spiritual Leader, Vedanta Society of New York), John Torous (Associate Professor of Psychiatry at Harvard Medical School and Director of Digital Psychiatry at Beth Israel Deaconess Medical Center), Dr. Vikram Patel (Paul Farmer Professor & Chair of Global Health and Social Medicine, Harvard Medical School), and Dr. Shirley Yen (Associate Professor of Psychology, Harvard Medical School) explored artificial intelligence, mental health, and consciousness. The discussion tackled some of humanity's biggest existential questions – whether AI can replace human beings and whether a mental health crisis is imminent. Conscious Planet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.consciousplanet.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Sadhguru App (Download): ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://onelink.to/sadhguru__app⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Official Sadhguru Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://isha.sadhguru.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Sadhguru Exclusive: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://isha.sadhguru.org/in/en/sadhguru-exclusive⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Inner Engineering Link: isha.co/ieo-podcast Yogi, mystic and visionary, Sadhguru is a spiritual master with a difference. An arresting blend of profundity and pragmatism, his life and work serves as a reminder that yoga is a contemporary science, vitally relevant to our times. Learn more about your ad choices. Visit megaphone.fm/adchoices

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.                               __________________________________________ In this episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of calorie restriction and fasting, two of the most studied interventions for healthy aging. Drawing on decades of research, Dr. Sinclair explains how eating less – and eating less often – affects the biology of aging, why our evolutionary past may predispose many of us to weight gain, and what the latest human and animal studies reveal about lifespan, metabolism, and disease risk. Whether you're interested in longevity, metabolism, or intermittent fasting, this episode provides an evidence-based look at one of the most powerful strategies for supporting health and longevity.                                __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN                                __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.  Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.   The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

This episode is part of our comprehensive Decipher the Guidelines Series covering the 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes.  The following question refers to Section 5.2.1 of the 2025 ACS Guidelines. The question is asked by Thomas Jefferson medical student and CardioNerds Academy Intern Dr. Grace Qiu, answered first by Henry Ford Interventional cardiology fellow and member of the CardioNerds Interventional Cardiology Council Dr. Li Pang, and then by expert faculty Dr. Michelle O'Donoghue. Dr. O'Donoghue is a cardiologist, senior investigator with the TIMI Study Group, and Associate Professor of Medicine at Harvard Medical School who holds the McGillycuddy-Logue Endowed Chair in Cardiology at Brigham and Women's Hospital. She was the Vice Chair of the Writing Committee for the 2025 ACS Guidelines. Question #2 A 63-year-old woman presented to the emergency room for chest pain. She described having exertional chest pain for the past two months and had an episode of severe pain after dinner 3 days ago. She went to bed and slept it off.  She told her children today at a family gathering, and was immediately brought to the ED by her daughter. She has a history of hypertension and hyperlipidemia. She was asymptomatic and normotensive in the ED. Labs show a down-trending troponin and an elevated NT-proBNP but are otherwise unremarkable. Her ECG showed Q waves with ST elevation in V2-V4. She was treated with aspirin and heparin drip, and taken to the cath lab. Coronary angiogram showed complete proximal LAD occlusion with right-to-left collaterals, without significant residual disease elsewhere. She remains asymptomatic and is stable, both hemodynamically and electrically. What is the next best step with regard to reperfusion and anti-thrombotic management? A Proceed with primary PCI to LAD  B Medical management with aspirin and enoxaparin  C Medical management with aspirin and clopidogrel D Medical management with aspirin and ticagrelor   Answer #2 Explanation  The Correct answer is D In patients who are stable with STEMI and have a totally occluded infarct-related artery >24 hours after symptom onset and are without evidence of ongoing ischemia, acute severe HF, or life-threatening arrhythmia, PPCI should not be performed due to lack of benefit. (Class 3, LOE B-R) The benefit of PPCI begins to diminish after >12 hours from symptom onset, but there appears to be continued benefit through approximately 24 hours.  In stable asymptomatic patients with an occluded artery >48 hours after symptom onset, routine PCI has not been shown to be beneficial in the absence of ongoing ischemia. The relative utility of routine PCI for asymptomatic patients with STEMI between 24 and 48 hours from symptom onset is less rigorously tested. PCI is not recommended for an occluded infarct-related artery if the patient is asymptomatic and has a completed infarct. MACE outcomes were similar in those with an occluded infarct-related artery who underwent medical therapy versus those who underwent PCI 3 to 28 days after an MI (Occluded Artery Trial [OAT]), and results were no different at 7-year follow-up. Similar findings were noted in the DECOPI (Desobstruction Coronaire en Post-Infarctus) trial, which enrolled patients with an occluded artery and Q waves on the ECG presenting 2 to 15 days after symptom onset. However, coronary revascularization should be considered for patients with late presentations with continued signs and symptoms of ischemia, including cardiogenic shock, acute severe HF, persistent angina, and life-threatening arrhythmias.  Main Takeaway In patients who are stable with STEMI who have a totally occluded infarct-related artery >24 hours after symptom onset and are without evidence of ongoing ischemia, acute severe HF, or life-threatening arrhythmia, PPCI should not be performed due to lack of benefit. Guideline Loc. Section 5.2.1 

In this episode of The Impostor Syndrome Files, we talk about burnout, workaholism and the pressure high achievers put on themselves to constantly prove their value. My guest this week is Amy Leneker, leadership consultant, self-described “recovering workaholic” and author of Cheers to Monday.Amy shares her personal journey through two major experiences with burnout, including the physical and emotional warning signs she missed along the way. We explore the connection between impostor syndrome, people pleasing and overachievement, and why many professionals struggle to separate external expectations from the pressure they place on themselves. Amy also reflects on the painful realization that changing jobs alone doesn't solve burnout when the underlying patterns follow you wherever you go.In our conversation, we discuss the importance of self-awareness, support systems and redefining identity beyond work. Amy shares how therapy, coaching and intentional recovery practices helped her reconnect with herself and rethink how she approaches success and leadership. We also talk about the role organizations play in creating healthier cultures and why shared responsibility matters when addressing stress and burnout at work.Finally, we explore Amy's research on stress and joy in the workplace, including the three biggest drivers of joy at work: meaning, mattering and momentum. Amy explains why joy is far more than a “nice to have,” how emotionally intelligent leaders still need to look inward and why taking care of ourselves creates a ripple effect for the people around us.About My GuestAmy Leneker is an optimistic, joy-seeking, recovering workaholic. She's also a leadership consultant who has helped over 100,000 leaders and teams – including those at Fortune 100 companies – lead with less stress and more joy. Her soul goal? To help one billion people do the same. With over 25 years of leadership experience – including a decade in the C-suite – Amy understands the soul-crushing toll of burnout because she's lived it. Twice. After surviving her own brush with burnout, Amy became determined to help others succeed without sacrificing their joy, their health, or their weekends. A first-generation college student, Amy earned both her undergraduate and graduate degrees while working full-time and later raising a family. She has studied leadership at Yale, neuroscience at the NeuroLeadership Institute, and stress resilience at Harvard Medical School.~Connect with Amy:Website: https://www.amyleneker.com/Book: https://www.amazon.com/Cheers-Monday-Surprisingly-Simple-Method/dp/1394388802~Connect with Kim and The Impostor Syndrome Files:Join the free Impostor Syndrome Challenge:https://www.kimmeninger.com/challengeLearn more about the Leading Humans discussion group:https://www.kimmeninger.com/leadinghumansgroupJoin the Slack channel to learn from, connect with and support other professionals: https://forms.gle/Ts4Vg4Nx4HDnTVUC6Join the Facebook group:https://www.facebook.com/groups/leadinghumansSchedule time to speak with Kim Meninger directly about your questions/challenges: https://bookme.name/ExecCareer/strategy-sessionConnect on LinkedIn:https://www.linkedin.com/in/kimmeninger/Website:https://www.kimmeninger.com

In this episode of the Well-Adjusted Mama Podcast, Dr. Laura Brayton sits down with licensed clinical psychologist and perinatal mental health specialist Dr. Nicole Pensak to discuss her new book, "Rattled: How to Calm New Mom Anxiety with the Power of the Postpartum Brain." Motherhood is often portrayed as a joyful experience, but many women find themselves struggling with anxiety, intrusive thoughts, overwhelm, and uncertainty during the postpartum period. Dr. Pensak shares how understanding the unique changes that occur in the postpartum brain can help mothers navigate this transition with greater confidence, resilience, and self-compassion. Together, they explore common challenges new mothers face, the signs of postpartum anxiety, depression, and OCD, and practical tools to support mental and emotional well-being during the perinatal period. About Dr. Nicole Pensak: Nicole Amoyal Pensak, PhD, is a nationally recognized licensed clinical psychologist certified in Perinatal Mental Health. She specializes in the treatment of anxiety, depression, and OCD and completed her training at Yale School of Medicine, followed by a postdoctoral fellowship at Harvard Medical School. Dr. Pensak owns a private practice in Monmouth County, New Jersey, and serves on the Expert Review Board for Parents magazine. Tune in for an empowering conversation that offers hope, education, and practical support for new and expecting mothers. More from Dr. Pensak: Instagram: https://www.instagram.com/DRNIKKIPENSAK/ Website: https://www.drnicoleamoyalpensak.com/ For more from Dr. Brayton: If you'd like to learn more about my virtual functional medicine practice, go to https://drlaurabrayton.com/virtual-functional-medicine/ and schedule a complimentary 15 minute discovery call with me. Help more people find our show - leave a rating and review by simply clicking on http://ratethispodcast.com/welladjustedmama. © 2014 - 2026 Dr. Laura Brayton

Dr. Karen L. Jacob is a clinical psychologist, Program Director of the Gunderson Residence at McLean Hospital, and Assistant Professor of Psychology at Harvard Medical School. She specialises in the assessment and treatment of personality disorders, with particular expertise in borderline personality disorder. In this conversation Karen talks about growing up with a love of art, spending four years after college searching for work that actually meant something, the influence of a father who treated the underserved his entire career, and what drew her unexpectedly to specialising in personality disorders. We also discuss a New Year's resolution with her husband that changed how she parents and how she works.It's a conversation about what it looks like to build a meaningful life with joy, and staying open to a path that keeps surprising you.For more of Dr. Karen L. Jacob's work:Profile: https://www.mcleanhospital.org/profile/karen-jacobFor more from Mark McCartney:Newsletter: https://www.whatisagood.life/Website: https://www.mmcleadership.com/LinkedIn: https://www.linkedin.com/in/mark-mccartney-14b0161b4/YouTube: https://www.youtube.com/ ⁨@whatisagoodlife3875⁩

In this episode, we will be speaking about having Less Stress, More Joy. We take a look at how to have a smarter, more empowering way to approach the stress that shows up in our work and daily lives. Instead of relying on outdated advice, we explore how to rethink stress, understand where it's really coming from, and take clear, practical steps to move forward with confidence. This conversation is all about cutting through the noise, reducing overwhelm, and discovering how small shifts can lead to meaningful change. If you're looking to feel lighter, more focused, and bring a greater sense of balance and satisfaction into your day, you won't want to miss it because joining us today is: Amy is an optimistic, joy-seeking, recovering workaholic he's also a leadership consultant with over 25 years of leadership experience, including a decade in the C-suite, who has helped over 100,000 leaders, teams, and organizations (from Fortune 100 companies to the public sector) thrive at work through keynotes, coaching, and training, centered on less stress and more joy. A first-generation college student, Amy earned both her undergraduate and graduate degrees while working full-time and later raising a family. She has studied leadership at Yale, neuroscience at the Neuro Leadership Institute, andstress resilience at Harvard Medical School.  Amy has appeared in Forbes, Katie Couric Media, Inc., CEOWORLDMagazine, and other prestigious outlets. She is a regular contributor to Fast Company and the author of the national research study, The State of Stress and Joy at Work 2026. She is also the author of Cheers to Monday, which has recently made the USA bestseller list. Which can be found on her website, AmyLeneker.com, or on Amazon.

Join our online community: https://www.skool.com/nailed-it-ortho/about  Dr. Gianakos Instagram: https://www.instagram.com/dr.ariannagianakos/?hl=en   In this episode, Dr. Ariana Gianakos joins us to talk about sports foot and ankle injuries. We cover common athletic injuries, evaluation strategies, treatment options, rehab, and the challenges of getting athletes safely back to play. Dr. Gianakos shares her journey into sports foot and ankle surgery, how her own athletic injuries shaped her career, and the international fellowship experiences that helped define her approach to treating elite athletes. We also discuss: Common sports-related foot and ankle injuries Key anatomy and physical exam pearls Imaging strategies and when to order MRIs Conservative vs surgical treatment options Return-to-play timelines for athletes Managing instability, tendon injuries, and high ankle sprains The role of PRP, biologics, and peptides in sports medicine Building global consensus in foot and ankle sports care Enjoy! Arianna Gianakos, DO, is an orthopaedic surgeon who specializes in sports-related injuries of the foot and ankle, including Achilles tendon injuries; ankle sprains and instability; ligament reconstruction; and trauma-related foot and ankle fractures, as well as various other foot and ankle conditions. Dr. Gianakos' interest in sports medicine—particularly foot and ankle sports medicine—is the result of a long, personal history with sports. She was an All-American Athlete, former collegiate basketball player, and track and field athlete who had her own share of injuries and orthopaedic surgeries. "My experience taught me the importance of having a physician who was passionate about getting patients back on their feet so they are able to return to sports," she says. "I chose a career where I could help patients in the same way my orthopaedic surgeons helped me." Her approaches include cutting-edge, minimally invasive surgeries, including in-office needle arthroscopy, and a variety of nonsurgical interventions, such as platelet-rich plasma (PRP) therapy, stem cell therapy, and fat cell therapy. In addition to her clinical work, Dr. Gianakos is an assistant professor of Orthopaedics & Rehabilitation at Yale School of Medicine. She has collaborated on studies of cartilage regeneration, tendon healing, and bone growth, and has a personal research focus on gender- and sex-related differences in foot and ankle injuries and outcomes. Dr. Ariana Gianakos earned her Bachelor of Science degree from McGill University before completing her Doctor of Osteopathic Medicine degree at Lake Erie College of Osteopathic Medicine. She went on to complete her orthopedic surgery residency at Rutgers Health, followed by a fellowship in Orthopedic Foot and Ankle Surgery at Massachusetts General Hospital through Harvard Medical School. She also completed advanced international training in foot and ankle IONA and sports medicine through NYU Langone Health. In addition, she is a PhD candidate at the University of Amsterdam, where her research focuses on gender and sex-related differences in foot and ankle surgery.   

While many people have heard of Dialectical Behavior Therapy (DBT) fewer know about Mentalization-Based Treatment (MBT), an evidence-based therapy that is producing remarkable results for people living with Borderline Personality Disorder (BPD). In this episode, host Gabe Howard sits down with Robert P. Drozek, LICSW, a teaching associate in psychiatry at Harvard Medical School and author of “Mentalization: Utilizing Reflection to Heal from Borderline Personality Disorder.” Together, they explore how mentalization—the ability to understand your own thoughts, feelings, and motivations while considering the perspectives of others—can help reduce the emotional instability, relationship challenges, impulsivity, and self-destructive behaviors often associated with borderline personality disorder. Robert explains what happens when intense emotions or fears of rejection disrupt a person's ability to accurately interpret themselves and others. He breaks down how Mentalization-Based Treatment works, what a typical therapy session looks like, and why some people who haven't connected with DBT may find MBT to be a powerful alternative. Listeners Will Learn: ·      Discover how Mentalization-Based Treatment (MBT) was developed and why it is evidence-based ·      Explore the key differences between MBT and Dialectical Behavior Therapy (DBT) ·      Find out what happens during a typical MBT therapy session ·      Understand how rigid certainty about yourself or others can fuel emotional suffering Whether you've been diagnosed with borderline personality disorder, love someone who has, or simply want to better understand this treatable mental health condition, this conversation offers hope, practical insights, and a fresh perspective on recovery. Listen now! “When (people with borderline personality disorder) are overwhelmed by emotion, they stop reflecting. Mentalization helps them get their minds back online.” ~Robert P. Drozek, LICSW Robert P. Drozek, LICSW, is the clinical director of the Mentalization-Based Treatment Clinic at McLean Hospital in Belmont, Massachusetts. He is a teaching associate in the Department of Psychiatry at Harvard Medical School, specializing in the treatment of borderline personality disorder, narcissistic personality disorder, and post-traumatic stress disorder. He is author of the new book, Mentalization: Utilizing reflection to heal from borderline personality disorder—the first book for the general public about mentalization-based treatment. Our host, Gabe Howard, is an award-winning writer and speaker who lives with bipolar disorder. He is the author of the popular book, "Mental Illness is an Asshole and other Observations," available from Amazon; signed copies are also available directly from the author. Gabe is also the host of the "Inside Bipolar" podcast with Dr. Nicole Washington. Gabe makes his home in the suburbs of Columbus, Ohio. He lives with his supportive wife, Kendall, and a Miniature Schnauzer dog that he never wanted, but now can't imagine life without. To book Gabe for your next event or learn more about him, please visit gabehoward.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

The latest public version of ChatGPT can be made to generate sexualised images or depict scenes of graphic violence with a simple prompt, researchers have told the BBC. British AI security startup Mindgard figured out how to make ChatGPT create graphic pictures by slightly altering a widely-shared instruction, or prompt, which was originally designed to produce humorous results. To find out more, Anita Rani speaks to Technology correspondent Chris Vallance and Mindgard's Peter Garraghan. A spokesperson for Open AI said: "We take these reports seriously. After investigating this trend, we've introduced additional safeguards against this type of prompt. Our safety systems are designed to block potentially harmful images that are uploaded to ChatGPT and we analyse whether the AI generated image violates our policies before we show the image to the user. We also combine automated systems and human review to identify and block harmful material.”Jon Snow, the lead presenter of Channel 4 News for 32 years, has revealed he has Alzheimer's disease. During his career, he reported on stories including the fall of the Berlin Wall, the release of Nelson Mandela and Barack Obama's inauguration, receiving numerous awards including the BAFTA Fellowship in 2015. In a new Channel 4 documentary, made in conjunction with the Alzheimer's Society, Jon Snow: A Last Big Story, he is seen uncovering an environmental disaster in Zambia. In her first broadcast interview since the diagnosis was announced, Jon's wife, Dr Precious Lunga, joins Anita to talk about how they are navigating life now. Testing the microbiome of your vagina is increasing in popularity, with direct-to-consumer companies offering at-home tests and claiming that this information is critical to women's health. Anita speaks with Dame Lesley Regan, Professor of Obstetrics and Gynaecology at Imperial College London, and Dr Caroline Mitchell, Professor of Obstetrics, Gynaecology and Reproductive Biology at Harvard Medical School, to discuss what we know about the vaginal microbiome and the recent surge in private testing. New novel Mrs Dickens by Emily Howes, tells the imagined story of Kate Hogarth, wife of the writer and journalist Charles Dickens. She is much loved at first, but as Charles finds fame and the family rise through the ranks of Victorian society, Charles's attitude towards Kate changes and she is devastated. Emily talks to Anita about how she pieced together and embellished the invisible life of Kate, a woman who bore Charles 10 children during a 22-year marriage and had an unparalleled view of one of the world's greatest writers.Presenter: Anita Rani Producer: Corinna Jones

What does self-awareness have to do with money, leadership and success? More than most people realize. In this episode of Money Tales, leadership expert Margaret Andrews shares how a single piece of difficult feedback early in her career sparked a lifelong pursuit of self-awareness, emotional intelligence and personal growth. From her beginnings as a CPA to teaching some of Harvard’s most popular leadership and executive education courses, Margaret explores how the beliefs we hold about ourselves quietly influence our careers, relationships, decision-making and financial lives. Her story offers practical insights for anyone looking to become a better leader, make more intentional choices and develop a healthier relationship with money. About Margaret Andrews: Harvard Leadership Instructor, Author and Expert in Emotional Intelligence Margaret is a seasoned professional speaker, executive, academic leader and instructor whose work has been written about in a variety of publications, including BusinessWeek, Forbes, The Wall Street Journal and The Times of India. Her course, Managing Yourself and Leading Others, is among the most popular classes and executive programs at Harvard. In addition, Margaret teaches Unlocking Creativity, Leading with Emotional Intelligence, Strategic Leadership, Creativity and Innovation, and It Depends: Unpacking the Challenges of Leadership. She is also the Co-Faculty Director of the Executive Program for Senior Life Sciences Leaders at Harvard Medical School. In the academic arena, Margaret has been Executive Director of the MBA Program at the MIT Sloan School of Management, Vice Provost at the Hult International Business School and Associate Dean at Harvard University. On the business side, Margaret started her career as a CPA in San Francisco and has also been a marketing executive and a long-time strategy consultant. She now leads The MYLO Center, a private leadership development firm. Margaret earned an undergraduate degree from the University of California, Berkeley and her graduate degree at the Massachusetts Institute of Technology (MIT). Her writing has been featured in Leader to Leader, Training Industry Magazine and Psychology Today and her book, Manage Yourself to Lead Others, was published by Hachette in 2025. Follow Money Tales on Spotify, Apple Podcasts or YouTube Music for more real stories that inspire thoughtful, intentional decisions about money.

Healthcare pioneer Rushika Fernandopulle joins us to discuss his new venture Liza and why this is the perfect moment to build new primary care models from the bottom up. Rushika argues that “shareholder value” has usurped the needs of patients in US healthcare, and that fundamental rethinking, not optimizing or tweaking at the edges, is needed. Rushika shares the ‘build principles' for Liza:Backload constraints - don't frontload them. First show that a new approach works, then figure out the business modelTake cues from conscious capitalism: the purpose of a business is to create good in the world, not to optimize shareholder value Figure out the right thing to do, not a business that fits how healthcare is brokenRushika argues that AI invites us to rethink healthcare based on abundance, not scarcity:“We've built our whole economy, all our processes with this assumption of scarcity, that there were a scarce number of human brains who could do things, right? Doctors, teachers, et cetera. And now all of a sudden that assumption has gone away. So we need to rethink from scratch how we build these systems. So that's what we're trying to do at Liza. Like, what if we started from scratch?”Relevant LinksMore information on LIZA HealthThe book Conscious Capitalism by John Mackey et alPodcast episode where Tim Ferris and Jerry Colonna talk about sabbaticalsArticle by Sara Riggare about living with Parkinson's and her image of blue and red dotsAbout Our GuestRushika Fernandopulle is a practicing physician who is the CEO of Liza Health, a startup building a new AI-enabled platform for Primary Care. He was the co-founder and CEO of Iora Health, an early innovator in Primary Care redesign which was acquired by Amazon in 2023. Prior to this, Rushika was the first Executive Director of the Harvard Interfaculty Program for Health Systems Improvement and Managing Director of the Clinical Initiatives Center at the Advisory Board Company. He is a member of the Schweitzer, Ashoka, Aspen, and Salzburg Global Fellowships, on faculty at Harvard Medical School. He serves on the boards of the Asian American Foundation, Families USA, and Premera Blue Cross, and is a member of the Lancet Commission for Person Centered Care. He earned his A.B., M.D., and M.P.P. from Harvard University, and completed his clinical training at the University of Pennsylvania and the Massachusetts General Hospital.SourceConnect With UsFor more information on The Other 80 please visit our website - www.theother80.com. To connect with our team, please email claudia@theother80.com and follow us on twitter @claudiawilliams and LinkedInSubscribe to The Other 80 on YouTube so you never miss our video extras or special video episodes!

Want more peace, presence + intuition in your life? Click here to download 6 Free Guided Meditations from The Miracle of You: https://www.alyssanobriga.com/miracle-dansiegel   ====   What if much of your anxiety, overthinking, and suffering comes from a case of mistaken identity?   In this episode, I sit down with renowned psychiatrist, bestselling author, and founder of interpersonal neurobiology, Dan Siegel, to explore who we are beyond our thoughts, emotions, stories, and conditioning.   Dan shares the neuroscience of pure awareness, how his Wheel of Awareness practice supports healing and integration, and why accessing presence can bring more peace, clarity, and freedom.   We also explore how trauma shapes the self, the four S's of secure attachment, and what it means to stay connected to yourself while being deeply connected to others.   If you've ever felt stuck in your mind, disconnected from yourself, or longing for a deeper sense of peace, this conversation offers a powerful roadmap back to what's always been within you. ====   Guest Bio: Dan Siegel is the Co-founder, with Caroline Welch, or Mind Your Brain in Santa Monica, California. He is also the Founder and Director of Education of the Mindsight Institute and founding Co-director of the Mindful Awareness Research Center at UCLA.   An award-winning educator, Dan is the author of five New York Times bestsellers and over fifteen other books which have been translated into over forty languages.   A graduate of Harvard Medical School, Dan completed his postgraduate training at UCLA specializing in pediatrics, and adult, adolescent, and child psychiatry. He was trained in attachment research and narrative analysis through a National Institute of Mental Health research training fellowship focusing on how relationships shape our autobiographical ways of making sense of our lives and influence our development across the lifespan.   Learn more about Dr. Siegel at: www.drdansiegel.com | www.mindsightinstitute.com ====   Website: alyssanobriga.com Instagram: @alyssanobriga TikTok - @alyssanobriga Spotify - https://open.spotify.com/show/6b5s2xbA2d3pETSvYBZ9YR Apple Podcast - https://podcasts.apple.com/us/podcast/healing-human-potential/id1705626495   ====   Alyssa Nobriga International, LLC - Disclaimer This podcast is presented solely for educational and entertainment purposes. It is not intended as a substitute for the advice of a physician, professional coach, psychotherapist, or any other qualified professional. We shall in no event be held liable to any party for any reason arising directly or indirectly for the use or interpretation of the information presented in this video. Copyright 2023, Alyssa Nobriga International, LLC - All rights reserved.

In this episode of Parallax, Dr Ankur Kalra is joined by Professor Ron Blankstein, a leading authority in preventive cardiology and cardiac imaging at Harvard Medical School and Brigham and Women's Hospital, Boston. Together they trace the remarkable journey of cardiac computed tomography (CT) from a niche diagnostic test to an indispensable pillar of contemporary cardiovascular practice. Professor Blankstein shares the moving story behind his new textbook, a companion to the legendary Braunwald's Heart Disease, recounting his personal collaboration with the late Dr Eugene Braunwald, who initiated the project and remained meticulously involved in its development until his passing. How has cardiac CT reshaped the diagnosis and management of coronary disease? What does the future of plaque analysis and photon-counting technology hold? And why should every cardiology fellow now consider CT essential to their training? Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

Election. Check it out–no money, no training, and no degree from Harvard Medical School, and the 12 Apostles are to go out and cure the sick. How is that possible? They were elected–chosen by the Lord. Let's say you were elected to be the mayor of the city. Immediately, you will have an office, a... The post Gospel-Homily for Eleventh Sunday in Ordinary Time (2026) appeared first on St. Clement Eucharistic Shrine.

How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him. Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. . You'll Learn: Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one How to physically grow your hippocampus through exercise, meditation, and nutrition Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like The 7 everyday things that are shrinking your brain right now How stress, loneliness, and isolation cause measurable brain atrophy Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health Why VO2 max predicts brain aging better than almost any other marker What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely Why mitochondria health is the foundation of both brain function and longevity Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Pique | Go to Piquelife.com/dave for 20% off. - BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance Resources: • Learn More About Dr. Fotuhi's Work At: https://drfotuhi.com/ • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:59 – Intro 03:00 – Cannabis & Nicotine 04:15 – Understanding Alzheimer's 05:38 – Five Pillars Explained 07:55 – Best Cognitive Training 09:08 – Brain Size & Growth 12:36 – B12 & Lab Ranges 17:48 – Head-to-Toe Evaluation 24:17 – Sex & Brain Health 25:43 – Loneliness & Isolation 33:59 – ApoE4 Genetics 35:28 – Alzheimer's Declining 48:44 – Lithium & Brain 59:38 – VO2 Max & Fitness 1:06:42 – Psychedelics 1:09:38 – GLP-1s & Brain 1:12:38 – Closing & Action Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.                               __________________________________________ In this first episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and pioneer in longevity research - returns and explores one of the most consequential questions in science: How can aging be slowed or reversed? Drawing on more than 25 years of research at the forefront of aging biology, Dr. Sinclair explains why humanity has entered a revolutionary period. Advances in science and technology have converged and transformed aging into a promising target for intervention. This episode is a sweeping introduction to the science, breakthroughs, and emerging technologies that are fundamentally reshaping how we think about aging, disease, and the future of human health.                                __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN                                __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.  Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.   The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

In this episode of The Visible Voices Podcast, I sit down with Dr. Scott Weiner, emergency physician, associate professor at Harvard Medical School, and founder of system-wide substance use disorder programming.  Dr. Weiner shares the patient cases that set his life's work in motion, including a fatal overdose on Boston Common that changed how he understood both medicine and advocacy.  Scott addresses the troubling gap in opioid education in American schools, the promise of wearable technology for monitoring patients in recovery, and the real reasons overdose deaths are finally starting to decline. Opioid use disorder is not a moral failure — it is a public health crisis. ▶ Subscribe on YouTube @resaelewissmd — new Visible Voices episodes Wednesdays.

 In this episode, we will focus on the latest in the research on ALS. ALS remains a devastating disease, but the field is now at an inflection point with a growing pipeline of precision therapies, trial-ready sites, and a new generation of clinician scientists - yet barriers persist. There is disease heterogeneity, limited trial access for patients, and rising development costs. For an update on ALS clinical trials and the Healey ALS MyMatch program, a centralized platform that matches participants to trials, we spoke with Dr. Suma Babu. Dr. Suma Babu is an associate professor of neurology at Harvard Medical School and co-director of the Neurological Clinical Research Institute at Mass General Brigham. She was interviewed by Dr. Ryan Jacobson, an associate professor of neurology at Rush University.    Disclosure: This episode does not award CME.

The job of scientists is a tough one - to take complex, multifaceted, messy concepts, and do their best to simplify them in a way that is understandable and digestible to the general public. However, today's guest, Dr. Lisa Feldman Barrett,  warns that if something is too simple, we probably shouldn't believe it.  Especially when it comes to human behavior and emotions, there's nothing simple about it - because variation is the norm - not averages.  And in today's episode, Dr. Barrett explains exactly why that is and how it should change the way we view and approach our interactions. Dr. Barrett is among the top 1% most cited scientists in the world for her revolutionary research in psychology and neuroscience. She is a University Distinguished Professor of Psychology at Northeastern University, and she holds appointments at Harvard Medical School and Massachusetts General Hospital, where she serves as Chief Science Officer for the Center of Law, Brain and Behavior. In addition to the books 7 ½ Lessons About the Brain and How Emotions Are Made, Dr. Barrett has published over 260 peer reviewed scientific papers. Not only do we dive into the scientific research that disproves the way many of us have been led to view emotions, Dr. Barrett also does a phenomenal job of speaking to these concepts in a way that helps us apply it to our daily lives. Specifically, we address “The Great Man Theory” - why there is no one-size fits all approach to emotions and what they mean How understanding emotional constructs on a deeper level can make people more adept at navigating social situations The physiological and psychological processes of how we give meaning to our emotions Specific instances where knowing this information can directly influence life outcomes for you and those you impact daily Referenced Resources: Website: Lisafeldmanbarrett.com Book: How Emotions Are Made Book:  7 ½ Lessons About the Brain  TED Talk: You Aren't At the Mercy of Your Emotions Research Article: Knowing what you're feeling and knowing what to do about it   Resources & Links: Art of Coaching for coaching programs and resources: https://artofcoaching.com/mentoring My Latest Book (Link to upcoming or referenced publication): https://amzn.to/4rZknhs Connect with Brett Bartholomew: LinkedIn Twitter   Follow Us: Website: ArtofCoaching.com Instagram: @coach_brettb X: @coach_brettb

A recent study found that the 988 Suicide & Crisis Lifeline may have contributed to a decline in suicide deaths among young people. This hour, we learn what the research tells us and what questions remain. We also hear from Connecticut advocates working to connect people with mental health resources and reduce stigma. Later, two residents share their personal experiences navigating mental health challenges and how speaking openly about those struggles can help others find support. If you or someone you know is experiencing a mental health crisis, you can call or text 988, the Suicide & Crisis Lifeline. It’s free, confidential, and offers support 24 hours a day. Guests: Anupam B. Jena: Professor of health care policy at Harvard Medical School and physician in the Department of Medicine at Massachusetts General Hospital Kai Belton:state representative for the 100th district, Middletown Jacquilyn Davis: Director of Learning Workforce Development, Mental Health Connecticut Rob Santos: Comedian and Connecticut resident Rachael Perillo: Connecticut resident Support the show: http://wnpr.org/donateSee omnystudio.com/listener for privacy information.

A simple test with 12 questions may help predict your risk of dementia, stroke, or depression says Dr Jonathan Rosand. He's the founder and director of the Brain Care Labs at Mass General Brigham and Harvard, and professor of Neurology at Harvard Medical School. He's developed the Brain Care Score that measures factors such as sleep, exercise, stress, blood pressure, and social connection. The goal is to show how small changes to everyday habits may help protect brain health and reduce the risk of disease. Now, through the Global Brain Care Consortium, that work is expanding worldwide, inviting people to track their brain health and contribute to long-term research. To learn your Brain Care Score go HERE or visit the Global Brain Care Coalition website to learn more about its work and how to get involved HERE

Harvard Professor Dr. JoAnn Manson reveals the final results of the VITAL trial: a landmark study on Vitamin D, telomeres, and disease prevention.Is Vitamin D the most underrated molecule in longevity science? Dr. JoAnn Manson, Professor of Medicine at Harvard Medical School and lead investigator of the massive VITAL trial, joins us to present groundbreaking new data. We move past the traditional focus on bone health to explore how 2,000 IU of Vitamin D preserves telomere length, effectively slowing biological aging by three years. Dr. Manson discusses the 22% reduction in autoimmune diseases and the 17% reduction in advanced metastatic cancers found within the 25,000-participant study. We also tackle the "BMI Gap", the critical reason why Vitamin D benefits are often blunted in certain populations, and the importance of the Vitamin D/Omega-3 synergy. This conversation provides a definitive clinical roadmap for anyone using these supplements to extend their healthspan. Rooted in gold-standard randomized controlled trial data, this is an essential update on the science of aging well.MEDICAL DISCLAIMER: Modern Healthspan provides reports on peer-reviewed longevity research. We do not provide medical advice, diagnosis, or treatment. The clinical findings presented by Dr. JoAnn Manson from the VITAL trial are for informational use only. Please see your physician before starting 2,000 IU of Vitamin D or any other supplement protocol.

In this Part 1 of 2 ASCO 2026 Highlights episodes, hosts Dr. Narjust Florez and Dr. Stephen Liu are joined by Dr. Alice Shaw and Dr. Jonathan Goldman to review some of the most impactful targeted therapy data presented at the 2026 ASCO Annual Meeting. The discussion explores the practice-changing LIBRETTO-432 trial in early-stage RET-positive NSCLC, long-term outcomes with lorlatinib in ALK-positive disease, emerging data for neladalkib, and promising results for sunvozertinib in EGFR exon 20 insertion–positive NSCLC, highlighting how these findings may influence treatment decisions across disease stages. Guests: Dr. Alice Shaw. is a Professor of Medicine at Harvard Medical School, Chair of Medical Oncology, and a thoracic oncologist at Dana Farber Cancer Institute. She is widely recognized as a pioneer in the field of ALK-positive non-small cell lung cancer, having led landmark clinical trials that established crizotinib, ceritinib, and lorlatinib as standards of care. Dr. Jonathan W. Goldman is a Professor of Medicine and thoracic oncologist at the UCLA David Geffen School of Medicine, where he serves as a principal investigator in the Phase I drug development program. Dr. Goldman has been at the forefront of early-phase oncology trials across multiple tumor types, with a particular focus on novel therapeutics in lung cancer, and he was the presenting author of Libretto 432 at the plenary session at the 2026 ASCO

You may think of allergies as causing sniffly noses and congestion in the spring or fall. But allergies can go far beyond that. As Dr. Kari Nadeau points out in this episode, allergies can affect us from head to toe, including eyes, nose, throat, lungs, sinuses, skin and gut. In the most dangerous instances, the whole body is threatened with an anaphylactic reaction. That's a medical emergency! One in three Americans will develop allergies at some point in our lives, so it's important to know what works to control them. At The People's Pharmacy, we strive to bring you up to date, rigorously researched insights and conversations about health, medicine, wellness and health policies and health systems. While these conversations intend to offer insight and perspective, the content is provided solely for informational and educational purposes. Please consult your healthcare provider before making any changes to your medical care or treatment. How You Can Listen You could listen through your local public radio station or get the live stream at 7 am EST on Saturday, June 6, 2026, through your computer or smart phone (wunc.org).  Here is a link so you can find which stations carry our broadcast. (Welcome, Huntsville, Alabama!) If you can't listen to the broadcast, you may wish to hear the podcast later. You can subscribe through your favorite podcast provider, download the mp3 using the link at the bottom of the page, or listen to the stream on this post starting on June 8, 2026. What Are Allergies? We begin our discussion of your allergy survival guide with an explanation of what is happening during an allergic reaction. The immune system perceives some foreign compound, usually a protein, as dangerous even though normally it would not be. So it reacts by trying to flush the invader out by producing extra mucus. The turbinate sinuses can make one to two gallons of mucus a day, and naturally, it has to go somewhere. That's why you might be congested. Having all that mucus in the sinuses can also encourage bacterial growth, so if the allergic reaction persists, some people have to deal with sinus infections. Emergency Treatment In determining what works, you need to know the nature of the reaction. If you have two or more organs involved, if you are having trouble breathing or if you feel dizzy, you may be in the midst of an anaphylactic reaction. What works for that is an epinephrine injection and immediate medical attention. This is potentially life-threatening, so you will want to figure out what triggered the reaction so you can avoid it in the future. Once someone has suffered one anaphylactic reaction, they should keep epinephrine with them at all times in case of another episode. Epinephrine comes as a self-injector pen or a nasal spray (neffy). Can You Spot Drug Allergies? In the warnings that are rattled off as part of a TV ad for a pricey new drug, we often hear viewers cautioned not to take the medicine if they are allergic to it. That sounds like simple common sense, but it also has a Catch 22 quality. How do you know you are allergic to a medication unless you take it–and experience an allergic reaction for which you might need treatment. Most of these presumably are immune system-mediated reactions, in which the body produces IgE. That is how allergies to penicillin or sulfa drugs work. Some drugs cause a different type of reaction, not IgE-mediated but dangerous nonetheless. Lisinopril is the most commonly prescribed blood pressure medicine in this country. Like other ACE (ACE is short for angiotensin-converting enzyme) inhibitor medications, lisinopril can trigger angioedema. This swelling can affect the face, lips, tongue and throat, where it can compromise breathing. The most insidious aspect of this reaction is that it can occur after the person has been taking the drug without problems for weeks, months or even years. “Red man syndrome” or infusion reactions in people taking vancomycin can likewise occur without warning. The last type of drug reaction is not actually an allergy at all, although people occasionally use that terminology. It is better described as sensitivity. For example, a stomachache is a common reaction to the antibiotic erythromycin. Some people are disabled by this abdominal pain and try to limit their exposure to erythromycin thereafter. What Works and What Doesn't? Since the immune system is acting inappropriately to cause allergic reactions, treatment should involve immunotherapy. Eye drops can help eyes feel less itchy and irritated. Likewise, OTC nose drops or nasal sprays can often help the nose. The corticosteroid Flonase (fluticasone) and the antihistamine Astepro (azelastine) are good examples. During allergy season, some people find that a daily nasal wash (with a neti pot or NeilMed device) can help reduce the mucus and remove the allergens such as pollen causing the reaction. There are also oral antihistamines and inhalers for asthma. For decades now, allergists have offered their patients shots to help desensitize them to the allergen causing their trouble. Joe had these as a child and teenager and has been largely free of allergies since. Not everyone gets such lasting relief. Complications from Current Therapies Medications have side effects, and that is true of allergy medicines as with other drugs. Antihistamines, especially the older ones like Benadryl (diphenhydramine), are notorious for causing drowsiness. That's one reason it is often included in nighttime pain relievers as the “PM” in drugs like Advil PM. We worry about regular use of such antihistamines because it has been linked to a greater risk for dementia. A second-generation antihistamine such as Allegra (fexofenadine) is much less likely to make someone feel sleepy. However, Dr. Nadeau has seen patients on antihistamines suffer worse allergies if they stop suddenly. The People's Pharmacy has received hundreds of reports from people who experienced unbearable itching upon discontinuing Zyrtec (cetirizine) or Xyzal (levocetirizine). This can last for weeks. Doctors don't usually worry much about steroid nasal sprays like Flonase because they are topical. Presumably, nasal tissues pick up most of the dose. Just the same, using such a nose spray day after day for a long time could result in systemic steroid exposure that is not trivial. Stronger Medicine Dr. Nadeau is enthusiastic about the benefits of two potent prescription medicines. One is Xolair (omalizumab). It was originally developed to prevent asthma, but is now approved for chronic sinusitis, food allergies and chronic hives. Paradoxically, Xolair is one of those medicines that could cause a severe allergic reaction even on the first dose, so the FDA warns that the initial injection should be given in a healthcare setting prepared to treat anaphylaxis. This is uncommon, though, occurring in 0.1 to 0.2% of patients. The other medication Dr. Nadeau is prescribing for allergy patients who don't respond well to other treatments is Dupixent (dupilumab). The FDA has approved this medicine to treat a wide range of conditions, including eczema, asthma, chronic sinusitis, allergic reactions affecting the esophagus and chronic hives, among other things. Most insurance companies will not cover this pricey injection unless the patient has failed all other therapies. Fighting Air Pollution: What Works Air pollution makes allergy symptoms worse, so using an effective air filter inside the home is a good step. A HEPA (high-efficiency particulate-arresting) filter is ideal, especially as part of the air-handling system. If that's not possible, utilizing a MERV 13 in the part of the home where you spend the most time is a good second choice. Sonu One new option for treating allergies is acoustic resonance therapy with the SoundHealth Sonu headband. It uses vibration from sound to loosen mucus from the sinuses so that they can clear. The FDA has approved its use for children as well as adults. New research was just published demonstrating its helpfulness in treating children with nasal congestion (Oto-Open, April-June 2026). SoundHealth has underwritten The People's Pharmacy podcast. Dr. Nadeau has also been compensated for her role in conducting studies of this device (International Forum of Allergy & Rhinology, Dec. 2025). Since it does not employ medications, there are no drug side effects. This Week’s Guest Kari C. Nadeau, M.D., Ph.D., is Dean of the UCLA Fielding School of Public Health ( starting July 1 2026). Until then, she holds many other positions. At Harvard T. H. Chan School of Public Health she is: John Rock Professor of Climate and Population Studies; Chair of the Department of Environmental Health; and Director of the Allergy, Extreme Weather, and Exposomics Lab. Dr. Nadeau is Professor of Medicine at Harvard Medical School and serves in the Division of Allergy and Inflammation at Beth Israel Deaconess Medical Center. She is an Adjunct Professor at Stanford Medical School. Dr. Nadeau is also the co-author of The End of Food Allergy, which provides strategies for treating and preventing food allergies in children. Here is a link to the research underway in her Harvard laboratory. PHOTO CREDIT: STACY GEIKENTaken in April 2017 at Kari Nadeau’s professorship dinner The End of Food Allergy: The Science-Based Plan That Turns Food into Medicine The People's Pharmacy is reader supported. When you buy through links in this post, we may earn a small affiliate commission (at no cost to you). Listen to the Podcast The podcast of this program will be available Monday, June 8, 2026, after broadcast on June 6. You can stream the show from this site and download the podcast for free. This episode has additional information about Nasalcrom (cromolyn sodium nasal spray) and its effect on mast cells; alpha gal allergy to red meat; and the latest thinking on preventing peanut allergy among young children. Download the mp3

Addiction affects millions of people, yet it remains one of the most misunderstood and stigmatized medical conditions. This week on SHE MD, Mary Alice Haney sits down with Dr. Sarah Wakeman, a nationally recognized addiction medicine specialist, Harvard Medical School faculty member, and leading advocate for evidence-based addiction treatment.Dr. Wakeman shares how her experiences treating patients revealed a troubling reality: people struggling with addiction are often treated very differently than those with other chronic illnesses. Together, they explore why addiction is a medical condition, not a moral failing, and what needs to change in healthcare, policy, and public perception.The conversation also dives into alcohol use, women's unique health risks, pregnancy, breast cancer, and the growing body of research on how alcohol impacts long-term health. This episode is an eye-opening discussion about stigma, recovery, compassion, and the power of treating addiction with science instead of judgment.Subscribe to SHE MD Podcast for expert tips on PMOS, endometriosis, fertility, hormonal balance, mental health, and more. Share with friends and visit SHE MD website and Ovii for research-backed resources, holistic health strategies, and expert guidance on women's health and well-being.SponsorsKa'Chava: Treat yourself to the flavor and nutrition your body craves. Go to kachava.com and use code SKINNY for 15% off your first order. Use code SHE MD at checkoutOsea: Get 10% off your first order sitewide with code SHEMD at oseamalibu.com. Myriad: Go to GetMyRisk.com to learn more about hereditary cancer testing and how you can use Myriad's virtual care option for fast, at-home testing - no office visit required.Peloton: Let yourself run, lift, sculpt, push and GO. Explore the new Peloton Cross Training Tread+ at onepeloton.comDavid: Buy 4 cartons of Protein Bars and get the 5th free when you go to davidprotein.com/SHEMD.What You'll LearnWhy addiction is a chronic medical conditionHow stigma impacts addiction treatmentWhy women experience alcohol differentlyThe link between alcohol and breast cancerAlcohol's effects during pregnancyCommon myths about addiction recoveryWhat evidence-based addiction care looks likeWhy compassion improves outcomesThe role of trauma in substance use disordersHow to support someone struggling with addictionKey Timestamps00:00 Why Alcohol Is More Dangerous Than Most People Think03:02 What Alcohol Actually Does To Your Brain06:48 Why Some People Become Addicted Faster Than Others10:42 The Science Behind Alcohol Cravings14:56 When Drinking Becomes A Real Problem18:37 Why Addiction Changes Your Brain22:14 Women & Why Alcohol Affects Them Differently26:03 Alcohol, Anxiety & The Sleep Problem30:21 Signs You May Need To Cut Back Drinking37:05 The Best Treatments For Alcohol Use Disorder41:36 New Medications That Reduce Alcohol Cravings44:43 Why Menopause Makes Alcohol Harder To Tolerate45:37 Teens, Alcohol & Parenting Conversations46:42 The Biggest Protective Factors Against Addiction53:05 Why Scare Tactics Fail Teenagers57:39 How To Help Someone With Alcohol Problems58:35 Why Tough Love Usually Doesn't Work01:01:17 Supporting Loved Ones Without Enabling01:07:58 Questions To Ask Yourself About DrinkingKey TakeawaysAddiction should be treated like any other chronic illness, with evidence-based medical care and long-term support.Stigma and judgment often prevent people from getting the treatment they need.Many people with addiction have histories of trauma, adversity, or significant life challenges.Alcohol carries real health risks, including an increased risk of breast cancer, even at lower levels of consumption.Women metabolize alcohol differently and may experience greater health impacts than men.Recovery is possible, especially when treatment is rooted in science, compassion, and individualized care.Language matters; how we talk about addiction can either reinforce stigma or support healing.Understanding addiction as a medical condition is essential to improving care and saving lives.Guest BioDr. Sarah Wakeman is a nationally recognized leader in addiction medicine, a graduate of Brown University, and a faculty member at Harvard Medical School. She is double board-certified in Internal Medicine and Addiction Medicine and serves as the Program Director of the Massachusetts General Hospital Addiction Medicine Fellowship.Throughout her career, Dr. Wakeman has been at the forefront of transforming how substance use disorders are treated, advocating for evidence-based, compassionate care that replaces stigma with science. She has helped develop innovative treatment programs, mentored the next generation of addiction medicine specialists, and worked to expand access to life-saving care for patients across the healthcare system.As a physician, educator, and national thought leader, Dr. Wakeman is passionate about changing the conversation around addiction; helping people understand that substance use disorder is a medical condition, not a moral failing, and that recovery is possible with the right support and treatment.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Description:  How do GLP-1 receptor agonists or GIP agonists work and what is the impact for my psoriatic disease? Hear dermatologist Dr. Ronald Prussick and cardio-immunologist Dr. Brittany Weber answer such questions and more.           Join host Archie Franklin as he takes a deep dive into the use of GLP-1 receptor agonists and GIP agonists and the convergence of systemic inflammation related to psoriatic disease with renowned dermatologist and Vice Chair of the NPF Medical Board, Dr. Ronald Prussick from Washington Dermatology Center in Rockville and Frederick, MD, and, cardio-immunologist Dr. Brittany Weber, Director of the Cardio-Rheumatology/ Cardio-Dermatology Program at the University of Texas Southwestern. Learn more about the use of incretin hormones, the impact of weight management on psoriatic disease, metabolic and cardiovascular risk, as well as results from the TOGETHER-Pso and TOGETHER-PsA clinical trials.  This episode addresses the actions of incretin hormones (GLP-1 receptor agonist and GIP agonist) and how such use may be beneficial in the management of inflammation related to psoriasis and psoriatic arthritis.  Thank you to Lilly for their support of this program activity.  Timestamps: (0:00)  Intro to Psoriasis Uncovered & guest welcome dermatologist Dr. Ronald Prussick and cardio-immunologist Dr. Brittany Weber.  (1:35)  What are incretin hormones and how GLP-1 or GIP receptor agonists (RA) inhibit appetite to initiate weight loss. (3:29)  Why GLP-1 RAs are of interest in the management of psoriasis and psoriatic arthritis. (5:23)  The metabolic, cardiovascular, and psoriatic disease convergence. (7:19)  Will reduction of inflammation impact cardiovascular risk? (10:59) Treatment challenges associated with having psoriatic disease and being overweight or obese. (13:45)  Key points around the use of GLP-1 receptor agonists when managing psoriasis and psoriatic arthritis. (17:06)  Results of the TOGETHER-PsO and TOGETHER-PsA phase 3 clinical trials combining use of an IL-17 inhibitor and a GIP and GLP-1                receptor agonist therapy. (19:07)  Having the conversation of adding a GLP-1 RA medication to a treatment regimen. (22:40)  The paradigm shift of GLP-1 receptor agonists and the impact they can have on shared inflammatory pathways. Key Takeaways: ·       Glucagon-like peptide-1 (GLP-1) receptor agonists and glucose-dependent insulinotropic polypeptide (GIP) agonists are two incretin hormones that assist in managing excess body weight -- which as a result can be helpful in managing inflammation in the body.   ·       Psoriasis isn't just a skin and joint disease. It's a complex network of systemic inflammation with shared inflammatory pathways that worsens with increased weight impacting the severity of the disease, and accelerates the risk of metabolic dysfunction, and cardiovascular disease.   ·       The best outcomes occur as a result of multidisciplinary collaboration to address the impact of excess weight and systemic inflammation. If you are struggling to lose weight with diet and exercise, speak with your medical team about your options including the use of GLP-1 or GIP agonists.   Guest Bios: Renowned dermatologist Ronald Prussick, M.D., Medical Director of the Washington Dermatology Center in Rockville and Fredrick, Maryland, specializes in the treatment of psoriasis along with other diseases of the skin, hair, and nails. Dr. Prussick is also a Clinical Associate Professor in Dermatology at George Washington University in Washington, D.C.. Dr. Prussick has a research interest in the impact of diet on psoriatic disease and metabolic health, first becoming interested after being involved in Dr. Joel Gelfand and Dr. Nehal Mehta's work in vascular inflammation trials using FDG-PET/CT scans to view systemic and cardiovascular inflammation associated with psoriatic disease. Dr. Prussick has since participated in the development of the 2018 Dietary Recommendations for Adults with Psoriasis or Psoriatic Arthritis and more recently the position statement "GLP-1 Receptor Agonists in Psoriasis: A Primer from the National Psoriasis Foundation Medical Board". Dr. Prussick is Vice Chair of the NPF Medical Board which provides clinical direction, treatment guidance, and education oversight to the organization and its Executive leaders.  Brittany Weber, M.D., Ph.D. is a cardio-immunologist who is the Director of the Cardio-Rheumatology/ Cardio-Dermatology Program at the University of Texas Southwestern. She is also a member of the Division of Cardiology, a clinical investigator, and imaging specialist. Dr. Weber's research integrates advanced imaging, molecular biology, clinical trials, and population health to understand how systemic inflammation and immune deregulation drives cardiovascular dysfunction. Prior to joining UT Southwestern in 2025, Dr. Weber served on the faculty at Harvard Medical School and was the Director of the Cardio-Rheumatology Clinic at Brigham and Women's Hospital, a nationally recognized clinic addressing inflammation-related heart disease through collaborative, patient centered care. Dr. Weber is also an author on the position statement "GLP-1 Receptor Agonists in Psoriasis: A Primer from the National Psoriasis Foundation Medical Board". Resources: "The Metabolic Collison and How You Can Take Control with Psoriatic Disease" podcast episode with dermatologist Dr. Ronald Prussick and registered dietitian Danielle Cahalan   "NPF Medical Board Issues GLP-1 Primer for Dermatologists" Press Release "Finding My Path to Managing Psoriatic Disease and Excess Weight" podcast episode featuring dermatologist Dr. Erin Boh, patient advocate Brian Lehrschal, and moderator Jennifer Bomberger. 

 Dr. Khameer Kidia is a physician and mental health researcher at Harvard Medical School and University of Zimbabwe. He headlined the Globe's Health Equity Summit this year, discussing the ways that Western psychiatry fails to meet the demands of our unequal world. On stage with Say More's Anna Kusmer, Dr. Kidia talks about using the wisdom of grandmothers to help alleviate mental suffering in Zimbabwe and what he learned from his mentor Dr. Paul Farmer, who cofounded Partners in Health. Email us at saymore@globe.com.

In episode 78 of Going anti-Viral, Dr Rajesh T. Gandhi joins host Dr Michael Saag to discuss the process of guidelines development. Dr Gandhi is a Professor of Medicine at Harvard Medical School and Principal Investigator and Co-Director of the Harvard University Center for AIDS Research (CFAR). Dr Gandhi is the Vice-Chair of the ACTG, Vice-Chair of the Infectious Diseases Society of America COVID-19 Treatment Guidelines Panel, Chair of the International Antiviral Society-USA Panel on Antiretroviral Drugs for Treatment and Prevention of HIV in Adults, and the Lead Editor for Infectious Diseases, NEJM Clinician. Dr Gandhi and Dr Saag explore the intricate process of developing HIV treatment guidelines, including evidence review, panel selection, and updates on new topics like transgender care and substance use disorders. They discuss how guidelines are created, their impact on clinical practice, and future directions in HIV care.0:00 – Introduction 1:54 – The purpose and impact of guidelines4:00 – Panel composition and selection process6:00 – Guideline structure and key updates12:34 – Emerging topics: transgender care and transplant medicine14:31 – Substance use disorders and treatment innovations16:03 – Evidence-based recommendations and their strength22:07 – Guidelines development process and team dynamics24:42 – Living guidelines versus published documents28:41 – Closing thoughts and future directionsResources: Going-anti-Viral: Episode 32 - Update on the New Antiretroviral Therapy Guidelines - Dr Rajesh GandhiYouTube:  https://youtu.be/G7FQTInz-dY Apple Podcasts:  https://podcasts.apple.com/us/podcast/episode-32-update-on-the-new-antiretroviral-therapy/id1713226144?i=1000678818027 __________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...

In this episode, Dr. Stuart Slavin welcomes Dr. Daniel Saddawi‑Konefka, associate professor of anesthesia at Harvard Medical School and co-founder of the Emotional PPE Project, for a thoughtful conversation on improving access to mental health care for health care professionals. Dr. Saddawi‑Konefka shares the origins of the Emotional PPE Project, created during the COVID‑19 pandemic to connect clinicians with free, confidential, and accessible mental health support, and outlines its dual focus on immediate care and long‑term cultural change. The discussion explores the complex, multi‑layered barriers that prevent physicians and physician learners from seeking care, including stigma, fears around confidentiality and professional consequences, and persistent logistical challenges such as time, cost, and access. Dr. Saddawi‑Konefka highlights how deeply ingrained cultural norms in medicine can discourage help‑seeking, but emphasizes the importance of system‑level reform, leadership, and education in shifting those patterns. The conversation further examines the role of leadership and local culture in promoting psychological safety, normalizing vulnerability, and encouraging timely support for mental health needs. Dr. Saddawi‑Konefka also introduces the concepts of hedonic and eudaimonic well‑being, illustrating how both comfort and meaning are essential to sustaining fulfillment in medicine. Throughout the episode, listeners will gain practical insights into how reducing barriers, improving access to care, and fostering supportive environments can help health care professionals thrive while delivering high‑quality patient care. Podcast Chapters (00:00) – Intro and Guest Introduction (00:48) – Origins of the Emotional PPE Project (01:57) – Mission: Removing Barriers to Care (03:53) – Scale & Access to Mental Health Support (05:03) – Key Barriers: Culture, Stigma, and Logistics (07:27) – Generational Shifts & Ongoing Stigma (08:22) – Culture Change in Medicine (10:26) – Systems, Leadership & Multi-Level Solutions (12:55) – Education & Understanding Mental Health (17:38) – Leadership & Role Modeling Vulnerability (20:02) – Meaning vs. Comfort in Well-Being (23:26) – Final Reflections & Takeaways (23:59) – Closing & Resources  

Forrest is joined by neurogastroenterologist Dr. Trisha Pasricha for a conversation about the gut-brain connection, including how gut health impacts our mood and mental health. Dr. Pasricha explains how the gut and the brain communicate, how early gut experiences can shape adult anxiety and depression, why GI symptoms are often misunderstood or dismissed, and what the research actually says about probiotics, leaky gut, and detoxification. They also discuss simple, evidence-based ways to improve gut health, dispelling social-media fueled myths along the way.  About our guest: Dr. Tricia Pasricha is a physician-scientist at Beth Israel Deaconess Medical Center, an assistant professor of medicine at Harvard Medical School, and columnist for the Washington Post. Her new book, You've Been Pooping All Wrong, explains the connection between your gut, your brain, and your mental health. Key Topics: 0:00 Intro: what's neurogastroenterology? 5:48: Believing your patient 9:31: The lifelong impact of childhood gut issues 18:27: The relationship between the gut and the brain 23:20: The tiktokification of gut health information 30:56: Probiotics – do they help? 34:15: The microbiome 43:34: Advice to people with gut issues 46:21: What about cleanses? 55:52: Recap Support the Podcast: We're on Patreon! ⁠If you'd like to support the podcast, follow this link.⁠ Sponsors Go to ⁠Zocdoc.com/BEING⁠ to find and instantly book a top-rated doctor today. Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode's Community Champion Sponsor is Ossur. To learn more about their ‘Responsible for Tomorrow' Sustainability Campaign, and how you can get involved: CLICK HEREEpisode Overview: Physician shortages, relentless reimbursement cuts, and rising burnout are quietly destabilizing the hospitals that communities depend on most.Dr. John Birkmeyer is confronting these challenges head-on as president of Sound Physicians, a physician-founded organization partnering with more than 400 hospitals across 45 states to deliver high-quality inpatient care.A Harvard Medical School graduate and member of the National Academy of Medicine, Dr. Birkmeyer brings decades of health services research alongside executive leadership at Dartmouth Health to bear on the most pressing problems in hospital medicine today.Join us to discover how Dr. Birkmeyer and Sound Physicians are leveraging data-driven performance improvement, physician-led culture, and emerging AI tools to reduce burnout, navigate reimbursement pressures, and build a more sustainable future for inpatient care. Let's go!Episode Highlights:Dr. Birkmeyer joined Sound Physicians serendipitously, connecting through a headhunter after Dartmouth hospital partnerships fell through.Sound Physicians serves 400+ hospitals across 45 states, employing roughly 5,000 clinicians in hospital-based specialties.Medicare physician payment cuts of 7 to 8% follow six years of annual cuts, accelerating consolidation and threatening independent practices.Physician burnout stems not just from overwork, but from loss of autonomy and control over their daily practice decisions.AI will reduce documentation burden (25 to 30% of physician time) while hospital-at-home models represent Sound's next major growth frontier.About our Guest:Dr. John Birkmeyer leads the Sound medical group and is responsible for clinical affairs and performance across all specialties. A graduate of Harvard Medical School and member of the National Academy of Medicine, Dr. Birkmeyer served as Executive Vice President and Chief Academic Officer for Dartmouth Health. He is a nationally recognized health services researcher with expertise in understanding variation in hospital and provider performance, scalable strategies for quality improvement, and value-based reimbursement.Links Supporting This Episode: Sound Physicians page: CLICK HEREDr. John Birkmeyer LinkedIn page: CLICK HERESound Physicians LinkedIn page: CLICK HEREMike Biselli LinkedIn page: CLICK HEREMike Biselli Twitter page: CLICK HEREVisit our website: CLICK HERESubscribe to newsletter: CLICK HEREGuest nomination form: CLICK HERE

"You shouldn't be spending more than five minutes in there at a time,” says Trisha Pasricha, MD, MPH. A graduate of Harvard College, Pasricha earned her medical degree from Vanderbilt University School of Medicine and a Master of Public Health from the Harvard T.H. Chan School of Public Health. Her training includes an internal medicine residency at The Johns Hopkins Hospital and gastroenterology and motility fellowships at Massachusetts General Hospital. Currently, Pasricha is an assistant professor of medicine at Harvard Medical School and director of the Institute for Gut-Brain Research at Beth Israel Deaconess Medical Center, an NIH-funded research laboratory at the forefront of gut-brain science. Her book, You've Been Pooping All Wrong, is out now.  00:00 - What actually makes a bowel movement healthy 07:55 - The Bristol Stool Chart explained 10:50 - The case for bidets 14:49 - What hemorrhoids actually are 17:44 - The smartphone-hemorrhoid study 20:33 - Fiber timing & psyllium husk 24:03 - The rise in early-onset colorectal cancer 27:43 - Microbiome testing 30:03 - The future of gut health 32:33 - Why we can't poop when traveling 35:40 - How much gas is actually normal 38:01 - Runners with the runs 41:10 - How to overhaul your gut in 30 days Referenced in the episode:  For more about Pasricha, visit her website: https://www.trishapasricha.com/  Buy Pasricha's book here: https://a.co/d/0gZZImBR  Smartphone usage on the toilet study: https://pmc.ncbi.nlm.nih.gov/articles/PMC12407481/ We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Quantas vezes você já varreu uma frustração para debaixo do tapete em nome de uma falsa positividade? Para muitas mulheres que já conquistaram seus espaços profissionais, a regra do jogo sempre foi vestir a armadura, ser forte o tempo todo e ignorar o cansaço ou o medo. Mas qual é o preço fisiológico e psicológico que a gente paga por silenciar quem somos e engarrafar o que sentimos?  No episódio #558, gravado diretamente do Flash Humanidades, o Mamilos recebe uma convidada mais do que especial para nos ajudar a tirar essa armadura: Susan David. Psicóloga premiada da Harvard Medical School, autora do best-seller Agilidade Emocional e uma das principais pensadoras globais em comportamento humano. Contrariando os gurus da internet, a Susan nos mostra que a resposta para as incertezas de hoje não é a resiliência cega ou a disciplina punitiva, mas sim a forma como nos relacionamos com as nossas próprias emoções.  Durante a conversa, Susan desconstrói o mito das emoções "ruins", entendendo que a raiva, o medo e a tristeza não são sentimentos que devem ser evitados, porque as emoções não são boas nem ruins, elas simplesmente são. Ela ensina também a diferença fundamental entre sentir e reagir: as nossas emoções são dados importantíssimos, mas não devem ser encaradas como ordens ou diretrizes inquestionáveis.Além disso, mergulhamos no conceito de vulnerabilidade sábia no ambiente de trabalho, compreendendo por que devemos agir e liderar a partir das nossas cicatrizes, e não exigindo que a equipe lide com as nossas feridas abertas. O papo de hoje é um respiro, um abraço e um convite para você criar um vocabulário novo para o que sente. Aperta o play e vem com a gente

We are excited to celebrate the launch of IFS Collected Wisdom: Conversations with Experienced Voices in Internal Family Systems a book that brings together voices, reflections, and lived experience from across the IFS community. This book was created from a desire to honor those voices, and to acknowledge that wisdom in IFS doesn't live in one place or one person. It lives in relationship, in experience, and in the field as it evolves. Thank you for being a listener, for being part of this community,  and for continuing to explore what becomes possible when Self leads. We hope that IFS Collected Wisdom can become a companion in your IFS journey. Here is a link to the IFS Collected Wisdom book contents. The Role of Uncertainty in Mental Health with Sarah Bergenfeld and Martha SweezyIn this episode, we welcome two leading voices in Internal Family Systems therapy for a conversation that bridges neuroscience, sensory experience, and healing. Sarah Bergenfield is a certified Level 3 IFS practitioner, writer, and educator specializing in autistic individuals and couples. Autistic herself, Sarah weaves together IFS, polyvagal theory, predictive processing, and sensory science in her clinical and consultation work. She teaches internationally for clinicians working with neurodiverse clients, and her work reframes autism not as a deficit, but as a condition of sensory surplus. Martha Sweezy is an assistant professor of psychiatry at Harvard Medical School, program consultant and supervisor at the Center for Mindfulness and Compassion at Cambridge Health Alliance, and a psychotherapist in private practice in Northampton, Massachusetts. She teaches IFS nationally and internationally and has authored and co-edited numerous books on the model, including Internal Family Systems Therapy, Second Edition (with Richard Schwartz), Intimacy from the Inside Out (with Toni Herbine-Blank), and Internal Family Systems Therapy for Shame and Guilt.Together, Sarah and Martha are co-authors of Wired to Feel: Autism as a Condition of Sensory Surplus.In this episode, we explore the role of uncertainty in mental health: how it can quietly drive distress and shame, and how IFS offers a path toward resolution. While the conversation has special relevance for autistic systems, the insights apply across all neurologies.

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  Curious just how much the gut can affect the skin? We are too. This week, we're joined by Dr. Jean McGhee as she walks us through the relationship between the gut microbiome and the skin. Listen in as she discusses stool testing, gut health, the importance of diet, and just what dysbiosis really means. Each Thursday, join Dr. Raja and Dr. Hadar, board-certified dermatologists, as they share the latest evidence-based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com. Jean McGee, MD, PhD, MS, is an Associate Professor of Dermatology at Harvard Medical School and the Director of Microbiome Research in the Department of Dermatology at Brigham and Women's Hospital. She runs a clinical research program focused on elucidating the role of the gut-skin axis in the pathogeneses of inflammatory skin diseases.

From Discovery to Delivery: Charting Progress in Gynecologic Oncology, hosted by Ursula A. Matulonis, MD, brings expert insights into the most recent breakthroughs, evolving standards, and emerging therapies across gynecologic cancers. Dr Matulonis is chief of the Division of Gynecologic Oncology and the Brock-Wilson Family Chair at the Dana-Farber Cancer Institute, as well as a professor of medicine at Harvard Medical School, both in Boston, Massachusetts.In this episode, Dr Matulonis was joined by Meghan E. Shea, MD, an attending medical oncologist and ambulatory medical director and disease program leader for medical oncology at Beth Israel Deaconess Medical Center in Boston. Together, they explored the current landscape of cervical cancer, from the urgent need for expanded vaccination and screening to the evolving role of immunotherapy and antibody-drug conjugates (ADCs) across disease settings.Dr Shea opened by addressing the epidemiology of cervical cancer, noting that despite decades of progress, rates are now plateauing and rising among women under 50 years of age. She identified 3 interrelated drivers of this trend: declining rates of routine gynecologic screening, inconsistent uptake of human papillomavirus (HPV) vaccination, and persistent high-risk HPV infections, particularly HPV 16 and 18, which are responsible for most cases. The conversation then turned to the effect of immunotherapy on cervical cancer treatment. Dr Shea traced the evolution of pembrolizumab (Keytruda) from its initial 2018 approval as a single agent in recurrent/metastatic disease to its more recent integration into the frontline setting. The phase 3 KEYNOTE-A18 trial (NCT04221945) demonstrated that adding pembrolizumab to standard weekly cisplatin-based chemoradiation significantly improved outcomes for patients with locally advanced disease. Although responses to immunotherapy, when they occur, are often durable, Dr Shea acknowledged that response rates remain lower than anticipated for a virally driven malignancy, underscoring the need for novel combinations and a deeper understanding of resistance mechanisms. Drs Matulonis and Shea both agreed that immunotherapy combined with ADCs represents one of the most compelling directions for the field, with phase 2 data for sacituzumab tirumotecan plus pembrolizumab generating interest ahead of anticipated phase 3 results.On the ADC front, Dr Shea reviewed the 2 agents in this class that are currently FDA-approved for cervical cancer. Tisotumab vedotin-tftv (Tivdak) offers the advantage of biomarker-independent use, though its requirement for ophthalmologic monitoring at every treatment visit creates real-world access challenges outside major academic centers. Trastuzumab deruxtecan-nxki (Enhertu), approved in the HER2 immunohistochemistry 3+ setting based in part on the results of the phase 2 DESTINY-PanTumor02 trial (NCT04482309), has generated robust response rates but is most likely to benefit patients with adenocarcinoma. Dr Shea also highlighted additional targets under investigation, including Trop-2, Nectin-4, and B7-H4, with multiple phase 3 trials ongoing in both the frontline and recurrent settings.The discussion closed with a look at the locally advanced disease landscape, where the NRG Oncology cooperative group is conducting a phase 3 trial to evaluate whether integrating the neoadjuvant carboplatin/paclitaxel regimen from the INTERLACE trial (NCT01566240) with the pembrolizumab-based regimen from KEYNOTE-A18 can further improve outcomes and reduce the morbidity associated with brachytherapy. Dr Shea expressed optimism about this question, citing preliminary experience suggesting that neoadjuvant chemotherapy may reduce the need for invasive radiation techniques.

Quantas vezes você já varreu uma frustração para debaixo do tapete em nome de uma falsa positividade? Para muitas mulheres que já conquistaram seus espaços profissionais, a regra do jogo sempre foi vestir a armadura, ser forte o tempo todo e ignorar o cansaço ou o medo. Mas qual é o preço fisiológico e psicológico que a gente paga por silenciar quem somos e engarrafar o que sentimos?  No episódio #558, gravado diretamente do Flash Humanidades, o Mamilos recebe uma convidada mais do que especial para nos ajudar a tirar essa armadura: Susan David. Psicóloga premiada da Harvard Medical School, autora do best-seller Agilidade Emocional e uma das principais pensadoras globais em comportamento humano. Contrariando os gurus da internet, a Susan nos mostra que a resposta para as incertezas de hoje não é a resiliência cega ou a disciplina punitiva, mas sim a forma como nos relacionamos com as nossas próprias emoções.  Durante a conversa, Susan desconstrói o mito das emoções "ruins", entendendo que a raiva, o medo e a tristeza não são sentimentos que devem ser evitados, porque as emoções não são boas nem ruins, elas simplesmente são. Ela ensina também a diferença fundamental entre sentir e reagir: as nossas emoções são dados importantíssimos, mas não devem ser encaradas como ordens ou diretrizes inquestionáveis.Além disso, mergulhamos no conceito de vulnerabilidade sábia no ambiente de trabalho, compreendendo por que devemos agir e liderar a partir das nossas cicatrizes, e não exigindo que a equipe lide com as nossas feridas abertas. O papo de hoje é um respiro, um abraço e um convite para você criar um vocabulário novo para o que sente. Aperta o play e vem com a gente

Guest: Dr. Vijay Sankaran is a Professor at Harvard Medical School and Investigator at the Howard Hughes Medical Institute. He discusses how his lab uses human genetics and stem cell biology to uncover mechanisms regulating hematopoiesis and blood disease, including the discovery of key regulators such as BCL11A and HOTSCRAMBL. He also explores how advances in genome editing, stem cell engineering, and single-cell genomics are shaping new therapies for disorders such as sickle cell disease, thalassemia, and leukemia, while highlighting the challenges of translating these breakthroughs into scalable patient treatments. Featured Products and Resources: Join us at ISSCR 2026 to catch the latest breakthroughs Learn to confidently apply the ISSCR Standards for Human Stem Cell Use The Stem Cell Science Round Up Building Pancreatic Cancer Models – A stem cell-derived organoid model reveals genetic and epigenetic mechanisms driving human pancreatic cancer initiation. Functional Cancer Stem Cell Assays – Researchers have developed a microwell platform that enables rapid enrichment of breast cancer stem cells for personalized drug testing. Human Pacemaker Assembloids – A human cardiac assembloid model recreates neural control of pacemaker activity and atrial conduction. Photo Reference: Courtesy of Dr. Vijay Sankaran. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In this episode of Medsider Radio, we sat down with Dr. Connie Lehman, founder and CEO of Clairity.Clairity is the first FDA-authorized AI platform that predicts a woman's five-year risk of developing breast cancer using only a routine screening mammogram.A physician scientist with over 300 peer-reviewed publications, Connie is a Professor of Radiology at Harvard Medical School and Breast Imaging Specialist at Massachusetts General Brigham (on leave). She holds an MD and PhD from Yale and was named to Forbes' 50 Over 50 Innovators and TIME 100 World's Most Influential Leaders in Health.In this interview, Connie discusses her experience translating academic research into a commercially viable startup, the massive undertaking of generating clinical evidence when you're creating a new category, and how Clairity is approaching adoption on two fronts: fitting into physician workflows and building access pathways for patients.Before we dive into the discussion, I wanted to mention a few things:First, if you're into learning from medical device founders and CEOs and want to know when new interviews are live, head over to Medsider.com and sign up for our free newsletter.And if you're ready to level up your medtech game, you should check out Medsider Courses — 8-week masterclasses covering topics like fundraising, M&A and exit planning, design and development, clinical and regulatory strategy, and commercialization.These courses, featuring hard-earned lessons from elite medtech CEOs, can be purchased individually or come free with our All-Access Pass.If you'd rather read than listen, here's a link to the full interview with Connie Lehman, which includes a link to ScottBot — an AI version of host Scott Nelson trained on every Medsider interview and playbook. Feel free to ask ScottBot any questions you'd like!KEY MOMENTS FROM THE INTERVIEW(03:04) - The broken screening paradigm Connie saw in clinic — and the gap that became Clairity (05:09) - How Clairity rolls the clock back from detection to predicting risk in healthy women (07:31) - Why "more data is better" turned out to be wrong and how that shaped Clairity's product scope (21:57) - How physicians can translate grant-generating discipline into building a company (24:56) - What 18 months of pre-sub meetings revealed about navigating a de novo pathway (26:49) - Why Clairity validated its technology in over 250,000 mammograms when FDA required far less (34:43) - How Connie flipped the natural question from "how can doctors offer this?" to "how can women access it?" (43:47) - How relationships, not pitches, drove Clairity's $43M Series B

In today's episode, we spoke with Jacob Sands, MD. Dr Sands is the associate chief of the Lowe Center for Thoracic Oncology, Oncology Medical Director of the International Patient Center, and physician at Dana-Farber Cancer Institute, as well as an assistant professor at Harvard Medical School in Boston, Massachusetts. In our exclusive interview, Dr Sands discussed the rapidly evolving treatment landscape for small cell lung cancer (SCLC), emphasizing both the progress made with immunotherapy and the ongoing challenges associated with this aggressive disease. He noted that outcomes now vary widely, with some patients experiencing long-term durable disease control following checkpoint inhibitor therapy, while others continue to have limited benefit from currently available treatments.A major focus of the discussion centered on tarlatamab-dlle (Imdelltra), the DLL3-targeting bispecific T-cell engager approved for relapsed SCLC. Sands described tarlatamab as a “new paradigm” therapy, highlighting results from the phase 3 DeLLphi-304 trial (NCT05740566) showing superiority in progression-free survival, overall survival, symptom improvement, and toxicity outcomes vs chemotherapy in the second-line setting. He also reviewed the evolution of DLL3 as a therapeutic target, explaining how earlier efforts with rovalpituzumab tesirine (Rova-T) helped establish the foundation for newer, more effective DLL3-directed approaches. The conversation also explored the growing role of molecular subtyping in SCLC, including emerging data involving ASCL1, NEUROD1, and POU2F3 transcription factor subsets. Although Sands cautioned that these findings remain investigational, he noted that subtype-driven treatment selection may eventually help personalize therapy in SCLC.Sands also addressed real-world experience with tarlatamab, including higher observed rates of cytokine release syndrome and neurologic toxicities among patients who would not have qualified for clinical trials. Despite these risks, he emphasized that many heavily pretreated patients with poor performance status or brain metastases have still achieved meaningful and durable clinical benefit.Finally, the discussion covered recent updates to National Comprehensive Cancer Network guidelines, including the establishment of tarlatamab as a preferred second-line standard of care regardless of chemotherapy-free interval. Looking ahead, Sands highlighted the growing pipeline of investigational therapies in SCLC, including CAR T-cell therapies, antibody-drug conjugates, radioligand therapies, and additional T-cell engagers, stressing the importance of clinical trial referral and collaboration between academic and community oncology centers.

Most of us don't think about brain health until something goes wrong. We think it's normal to experience brain fog or we just accept cognitive decline is inevitable as we age. Science shows you can physically change your brain at any age. You can grow new neurons, build stronger connections, and even shrink your risk of Alzheimer's — and it doesn't require anything mysterious or extreme. My guest is Dr. Majid Fotuhi, a renowned neurologist and one of the world's leading experts in brain health. He received his MD from Harvard Medical School and his PhD in Neuroscience from Johns Hopkins University School of Medicine, where he now serves as an adjunct professor at the Mind/Brain Institute. He's also the author of the new book The Invincible Brain. Some of the things we discuss are: Why your brain is an organ you can care for like your teeth or your heart — not a mysterious black box you're stuck with The 12-week brain fitness study that showed older adults physically grew their brains by 1–3%, making them up to three years younger on an MRI Why genetics play a surprisingly small role in late-life Alzheimer's — and how exercise can cancel out the effects of the highest-risk gene The exact amount of exercise that strengthens your brain (and why doing more than this won't help) Why sleep is an active brain-cleaning process — and what 20+ years of insomnia does to the memory center of your brain The one rule about food Dr. Fotuhi cares about more than keto vs. Mediterranean vs. vegetarian How chronic stress physically shrinks your brain, plus the perspective shift his daughter learned that keeps her calm under pressure Simple daily ways to challenge your brain — from memorizing names to license plates in traffic The Therapist's Take: My top three strategies for building a physically stronger, younger brain starting today Related Episodes ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 91 — The Biggest Threats to Your Brain Health and the Lifestyle Changes You Should Make Today to Stay Sharp with Dr. Austin Perlmutter 212 — What Are You Feeding Your Brain? Here's What You Need to Know About Your Mental Diet Links & Resources The Invincible Brain Connect with the Show Buy a copy of⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠13 Things Mentally Strong People Don't Do⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Connect with Amy on Instagram —⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@AmyMorinAuthor⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit my website —⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠AmyMorinLCSW.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Sponsors MUDWTR — Get up to 43% off your entire order, plus free shipping and a free rechargeable frother when you use code STRONGER at ⁠⁠⁠⁠⁠⁠⁠Mudwtr.com⁠⁠⁠⁠⁠⁠⁠. AirDoctor — Head to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠AirDoctorPro.com⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠and use promo code STRONGER to get UP TO $300 off today! One Skin — Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠oneskin.co/STRONGER⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and use code stronger to get up to 30% off your first 3 subscription orders First Day — Get up to 57% off and a free gift with code stronger at ⁠⁠⁠⁠FirstDay.com⁠⁠⁠⁠ Quince — Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Quince.com/stronger⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ for free shipping on your order and 365 day returns! Flamingo — Get a $7 starter set at ⁠⁠ShopFlamingo.com/STRONGER⁠⁠ Cozy Earth — Head to ⁠⁠cozyearth.com⁠⁠ and use code STRONGER20 to get 20% off your order. Subscribe to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Mentally Stronger Premium⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ for exclusive content like weekly bonus episodes, mental strength challenges, and office hours with me. Learn more about your ad choices. Visit megaphone.fm/adchoices

Judith Herman is widely known as a defining voice in trauma psychiatry for more than fifty years. Her work bridges the personal and the political, framing trauma as not only an individual experience, but a public health and human rights issue. In this interview with host Patricia Martin, Judith Herman tells the story of how her work evolved, what remains to be done for CPTSD victims, and what all of us can do to create conditions survivors need to heal. Judith Lewis Herman, MD, is Professor of Psychiatry (part time) at Harvard Medical School. For 30 years, until she retired, she was Director of Training at the Victims of Violence Program at The Cambridge Hospital, Cambridge, MA. She is the author of the award-winning books Father–Daughter Incest (Harvard University Press, 1981), and Trauma and Recovery (Basic Books, 1992). She is the recipient of numerous awards, including a Guggenheim fellowship in 1984 and the 1996 Lifetime Achievement Award from the International Society for Traumatic Stress Studies. In 2007 she was named a Distinguished Life Fellow of the American Psychiatric Association. Her new book, Truth and Repair: How Trauma Survivors Envision Justice, was published in March, 2023. Books by Judith Herman: Patricia Martin, MFA, is the host of Jung in the World. A noted cultural analyst, she applies Jungian theory to her work as a researcher and writer. Author of three books, her work has been featured in the New York Times, Harvard Business Review, Huffington Post, and USA Today. She holds an MFA in writing and literature from Bennington College and an MA in cultural studies at the University College, Dublin (honors). In 2018, she completed the Jungian Studies Program at the C. G. Jung Institute Chicago where she is a professional affiliate. A scholar in residence at the Chicago Public Library, for the last decade she's been studying the digital culture and its impact on the individuation process. Patricia travels the world giving talks and workshops based on her findings and has a private consulting practice in Chicago. Be informed of new programs and content by joining our mailing list! Support this free podcast by making a donation, becoming a member of the Institute, or making a purchase in our online store! Your support enables us to provide free and low-cost educational resources to all. This podcast is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. You may share it, but please do not change it, sell it, or transcribe it.Executive Producer: Ben LawHosts: Patricia Martin, Judith Cooper, Daniel Ross, Adina Davidson, and Raisa Cabrera2025-2026 Season Intern: Zoe KalawMusic: Peter Demuth

As cannabis policy and science evolve, so too does the conversation around how it fits into modern medicine—especially for older adults. In this episode, I'm joined by addiction specialist and Harvard Medical School instructor Peter Grinspoon to discuss his book Aging Well with Cannabis: Feel Better, Sleep Better and Live Better with Marijuana and CBD. With cannabis now legalized in much of the United States, many older adults are exploring it as an alternative or complement to traditional pharmaceuticals for issues like chronic pain, insomnia, and anxiety. Dr. Grinspoon brings a medical, evidence-based lens to a rapidly changing landscape—one shaped by science, policy, and patient experience. This conversation explores aging, wellness, risk, benefit, and what responsible cannabis use looks like in real clinical practice.

What are the most important things you can do today to live longer and stay healthier while doing it? In this final Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph.D., a Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, revisits the most surprising insights from his #1-ranked Season 1 series, combining updated commentary with key moments from across all eight episodes. The result is a thought-provoking, focused, practical guide to the science of longevity – grounded in evidence and designed for real-world application. Whether you're new to longevity science or looking to refine your approach, this episode brings together the most important principles in one place so you can better understand not just what to do, but why it matters. At Lifespan, our mission is to help you and your loved ones live longer, healthier lives while supporting medical research aimed at breakthroughs to extend all our lives. Join us at: https://lifespan.com. We're building the world's largest longevity community who will grow, learn, and live longer together. Subscribe here for new Lifespan show episodes every two weeks. __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in strong science – and products our team has personally used for many years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode – from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat content and muscle gains (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan with code LIFESPAN ○. WHOOP: Get a free WHOOP band plus one month free at https://join.whoop.com/LIFESPAN with code LIFESPAN ○. Withings: Explore their smart health devices at https://withings.com/lifespan using code LIFESPAN __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research. The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

Dr. Peter Grinspoon—author of the new book Aging Well with Cannabis: Feel Better, Sleep Better, and Live Better with Marijuana and CBD—explains that senior citizens are the fastest growing demo of cannabis consumers. But they often need help accessing information and safely ingesting the plant. Dr. Grinspoon is a primary care physician and educator at Massachusetts General Hospital, an Instructor in Medicine at Harvard Medical School, and serves as a board member of the advocacy group Doctors For Cannabis Regulation, which works on legalizing cannabis with an eye toward social justice issues.  PATREON Please ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠support Great Moments in Weed HIstory on Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Supporters get exclusive access to video versions of this podcast and private seshes, plus cool rewards like a signed book. And it truly helps us make the best show possible. EPISODE ARCHIVE Visit our podcast feed for 150+ episodes of Great Moments in Weed History, and subscribe now to get a new weekly podcast every Weednesday.

A deadly hantavirus on a cruise ship off the coast of Africa is now raising questions around the world — and now, the first U.S. case of the Andes strain of hantavirus has been confirmed. To help make sense of what we know — and what we don't — Mosheh speaks with Dr. Jeremy Faust, an emergency physician at Brigham and Women's Hospital, assistant professor at Harvard Medical School, and author of the Inside Medicine Substack.They discuss how concerned Americans should actually be, how this is different from COVID, and what health officials are watching as passengers from the outbreak-linked cruise ship return home across multiple countries. Dr. Faust explains what makes the Andes strain unique, how it spreads, and why experts say the virus's “slow biology” may actually be reassuring.The conversation also covers the confirmed U.S. case, symptomatic passengers under monitoring, lessons from a deadly 2018 Andes strain outbreak in Argentina, public trust in health authorities after the pandemic, and whether there's any evidence the virus has become more transmissible.Plus: why hantavirus remains rare despite rats being common in major cities — and what would have to happen for this outbreak to become something far more serious.Follow Dr. Faust for more: Instagram (@jeremysamuelfaust) Threads (@jeremysamuelfaust) X / Twitter (@jeremyfaust) Mosheh Oinounou (⁠⁠⁠⁠@mosheh⁠⁠⁠⁠) is an Emmy and Murrow award-winning journalist. He has 20 years of experience at networks including Fox News, Bloomberg Television and CBS News, where he was the executive producer of the CBS Evening News and launched the network's 24 hour news channel. He founded the @mosheh Instagram news account in 2020 and the Mo News podcast and newsletter in 2022.

For many entrepreneurs, mental health takes a back seat to ambition, productivity, and the pressure to keep going no matter what. Dr. Aditi Nerurkar once lived by that belief, until chronic burnout during her 80-hour-a-week residency broke her body down so severely she feared a heart condition. That crisis sparked her healing journey and became the foundation for her 5 Resets for when life and business get hard. In this first episode of the Mental Wealth Series, Dr. Aditi shares science-backed tools to help entrepreneurs reduce stress, prevent burnout, and protect their mental health.  In this episode, Hala and Dr. Aditi will discuss:  (00:00) Introduction (01:52) The Global Stress and Burnout Crisis (03:37) Good Stress vs. Bad Stress  (05:36) Your Brain's Fight-or-Flight Response (10:19) True Resilience vs. Toxic Resilience (13:05) Dr. Aditi's Personal Burnout Breaking Point (37:00) The Five Resets Framework  (44:45) The “Buried Treasure” Wellness Exercise (52:11) Digital Boundaries for Mental Health (1:00:40) Monotasking for Focus and Productivity Dr. Aditi Nerurkar is a physician, public health expert, and Harvard Medical School faculty member specializing in stress, burnout, resilience, and mental health. She is also a nationally sought-after speaker, television correspondent, and the bestselling author of The 5 Resets, a science-backed guide to managing stress and improving mental well-being.  Sponsored By: Huel - Get over $50 in savings with the Discovery Bundle from Huel. Use my exclusive code YAP15 for 15% off at huel.com/yap15. Indeed - Get a $75 sponsored job credit to boost your job's visibility at Indeed.com/profiting Shopify - Start your $1/month trial at Shopify.com/profiting. Quo - Run your business communications the smart way. Try Quo for free, plus get 20% off your first 6 months when you go to quo.com/profiting Fabric - Protect your family with term life insurance from Fabric by Gerber Life. Apply today in just minutes at meetfabric.com/profiting  ZocDoc - Stop putting off those doctors' appointments. Find and instantly book a doctor you love today at Zocdoc.com/PROFITING  Blinkist - Turn the world's best nonfiction books into quick 15-minute reads or listens. Grab your free trial plus an exclusive 30% discount at blinkist.com/profiting   Remitly - Transfer money internationally with Remitly, with no hidden fees. Use code BUSINESS to get a $100 bonus after you send $300 or more. New customers only.  Prolon - Reset and rejuvenate your body with Prolon's five-day plant-based fasting mimicking program. Go to ProlonLife.com/PROFITING for 15% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program. Resources Mentioned: Dr. Aditi's Book, The 5 Resets: bit.ly/AN-T5R  Dr. Aditi's Website: draditi.com Dr. Aditi's Instagram: instagram.com/draditinerurkar Mental Wealth Playbook: yapmedia.com/mentalwealth  Active Deals - youngandprofiting.com/deals  Key YAP Links Reviews - ratethispodcast.com/yap YouTube - youtube.com/c/YoungandProfiting Newsletter - youngandprofiting.co/newsletter  LinkedIn - linkedin.com/in/htaha/ Instagram - instagram.com/yapwithhala/ Social + Podcast Services: yapmedia.com Transcripts - youngandprofiting.com/episodes-new  Entrepreneurship, Entrepreneurship Podcast, Business, Business Podcast, Self Improvement, Self-Improvement, Personal Development, Starting a Business, Strategy, Investing, Sales, Selling, Psychology, Productivity, Entrepreneurs, AI, Artificial Intelligence, Technology, Marketing, Negotiation, Money, Finance, Side Hustle, Startup, Mental Health, Career, Leadership, Mindset, Health, Growth Mindset, Biohacking, Motivation, Manifestation, Brain Health, Life Balance, Self-Healing, Positivity, Happiness, Sleep, Diet