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Dr. Chris Thompson, MD, Professor of Medicine at Harvard Medical School, Chief of Interventional Gastroenterology at Mass General Brigham in Boston, and Co-Director of the Center for Weight Management and Wellness, is a world-renowned expert on gastroenterology, metabolism, nutrition, and obesity medicine. He explains how your GI tract regulates hunger, fullness, and blood sugar, as well as the gut microbiome, metabolic health, and weight loss. We also discuss common GI tract issues and which particular tests or interventions are actually useful. We discuss both GLP-1 medications and non-GLP-1 approaches to weight loss. Given that gut health is vital to all the organs of the body, overall health, and longevity, our discussion ought to be of interest and practical value to everyone, including, of course, those struggling with gut health or weight loss challenges. Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Our Place: https://fromourplace.com/huberman Timestamps (00:00:00) Dr. Chris Thompson (00:02:16) Digestive Tract, Gut Hormones & Nutrient Absorption (00:08:06) Colon Microbiome & Colon Cancer Screening (00:11:13) Sponsors: LMNT & Lingo (00:13:40) Swallowing Problems & Zenker's Diverticula (00:16:08) Bowel Movements & Constipation (00:18:28) Fiber, Resistant Starch & the Gut Barrier (00:21:50) Intermittent Fasting & the Gut Microbiome (00:23:38) Fermented Foods, Microbial Diversity & Butyrate (00:27:12) H. pylori, Stress & Stomach Ulcers (00:30:20) GLP-1 Medications: Benefits & Limitations (00:33:42) Lower GLP-1 Doses, Weight Regain & Muscle Loss (00:37:35) GLP-1 Side Effects, Food Noise & Apathy (00:39:49) Bariatric Surgery & Medical Innovation (00:46:07) Sponsor: AG1 (00:47:44) Hunger & Satiety: Ghrelin, CCK, GIP & GLP-1 (00:50:01) Retatrutide & Combining Hormonal Targets (00:52:55) Ultra-Processed Foods, Overeating & Leptin (00:55:32) Incretin Discovery, Exendin-4 & the Gila Monster (00:59:35) Endoscopic Ultrasound & Pancreatic Biopsy (01:07:40) Early Metabolic Markers, CGMs & Fasting Insulin (01:13:06) Insulin Resistance & Metabolic Flexibility (01:15:53) Sponsor: Function (01:17:35) Patient Data, Screening & Treatment Adoption (01:26:31) AI, Robotics & Improving Procedures (01:29:27) Choosing a Surgeon & Measuring Procedure Quality (01:35:29) Image Guidance & Hyperspectral Imaging (01:37:19) Sponsor: Our Place (01:38:56) Diagnostics & Targeted Metabolic Treatments (01:42:45) Gastric Bypass, Foregut Exclusion & Diabetes (01:47:59) Duodenal Liners & Mucosal Resurfacing Research (01:52:58) Gut Permeability, Inflammation & Fatty Liver (01:59:39) Artificial Sweeteners, Fructose, Fats & Omega-3s (02:05:00) Resistance Training, Zone 2 Cardio & Intervals (02:06:31) Weight Set Point & Metabolic Adaptation (02:08:13) Endoscopic Sleeve Gastroplasty & Fundus Ablation (02:10:30) Magnetic Intestinal Connections & Combined Treatments (02:16:52) GLP-1 Gene Therapy Research (02:22:13) Innovation, Problem Solving & Teamwork (02:25:58) Zero-Cost Support, Sponsors & Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
Why do your fingers and toes sometimes feel freezing cold when the rest of you feels perfectly comfortable? It's actually your body doing something very deliberate to protect you. Listen and discover what's going on — and why warming those fingers and toes back up can be so difficult. https://health.clevelandclinic.org/why-are-my-hands-and-feet-always-cold-and-should-i-worry Are you getting enough sleep? Is it good-quality sleep? Why did you wake up at 3 a.m.? For a lot of people, sleep has become something to measure, manage and worry about. But all that effort may actually be making sleep worse. Sleep physiologist Stephanie Romiszewski says one of the best things you can do for your sleep may be to stop trying so hard. She has worked in sleep research at Harvard Medical School and is author of Think Less, Sleep More: From Panic & Perfectionism to Stress-Free Sleep (https://amzn.to/3SOGsmM). Listen as she explains why sleep is more resilient than you think — and how worrying about it can become the real problem. There is something almost irresistible about “new.” A new phone, new car, new clothes, new gadgets — new things grab our attention and promise that life will somehow be a little better once we have them. And today, getting something new is easier than ever. But all that novelty comes at a price in money, time and attention. Eric Athas, an editor at The New York Times, explores why we are so attracted to new things, why the feeling wears off so quickly and what we may gain by resisting the urge to constantly upgrade. He is author of Saying No to New: Why New Things Are Stealing Your Time, Money, and Happiness―And How to Take Back Your Life(https://amzn.to/4iTUs9c). Goosebumps are strange when you think about them. They appear when you're cold, scared or even moved by music — yet they don't seem to accomplish much. Turns out they once served a very useful purpose. Listen and discover why humans still get goosebumps even though we no longer have much use for them. https://humanorigins.si.edu/education/fun-facts/why-do-we-get-goose-bumps PLEASE SUPPORT OUR SPONSORS MONARCH: Write your own money story with Monarch! Use promo code SYSK at https://Monarch.com to get your 1st year of Monarch Core half off at just $50 TREES.COM: Right now, https://Trees.com have great deals on planting essentials, up to half off on select plants. And listeners to our show get 20% OFF their purchase when using the promo code SYSK at checkout. VINTED: Ready to clean out your closet and make some extra money?Download the Vinted app for free and start listing! With no seller fees, you keep every dollar you earn and for a limited time, enjoy free shipping in the US on Vinted. WAYFAIR: Ready to upgrade your home for way less? Head to https://Wayfair.com right now to shop all things home and get your space ready for less. QUINCE: Find your next Fall favorites at Quince! Go to https://Quince.com/sysk for free shipping on your order and 365-day returns. Now available in Canada, too! DELL: Built for those who want better. The Dell XPS, built for you! PLANET VISIONARIES: In partnership with The Rolex Perpetual Planet Initiative, this is Planet Visionaries. Listen or watch wherever you get your podcasts! KA'CHAVA: Ka'Chava's new Salted Caramel is the perfect balance of mouthwatering flavor and benefits. Embrace your salty side. Go to https://kachava.com and use promo code SYSK to get 15% off your first order! INDEED: Get a $75 Sponsored Job credit to help get your job the premium status it deserves at https://Indeed.com/PODCAST Learn more about your ad choices. Visit megaphone.fm/adchoices
There's a new wellness trend focused on an obscure capillary system that moves fluid around the body. Things like lymphatic walking, vibration plates, and compression boots have been touted as ways to stimulate the lymphatic system to combat bloating, flush away toxins, and generally promote health. So what is the lymphatic system, and what does it do? And is there anything to these claims? Flora gets some answers with the help of two experts: Timothy Padera, a researcher who has dedicated his career to better understanding how the lymphatic system works; and physical therapist Marc Miller, who treats cancer patients with manual lymphatic drainage. Guests:Dr. Timothy Padera is an investigator at Mass General Research Institute and a professor of radiation oncology at Harvard Medical School. Dr. Marc Miller is a certified lymphedema specialist and senior physical therapist at UT MD Anderson Cancer Center. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
What if lasting peace isn't something you find in the world, but something you train within your own mind?In this powerful conversation, Mike "C-Roc" sits down with Liam McClintock, founder of FitMind, a mental fitness nonprofit, and author of Fit Mind: 4 Steps to Lasting Bliss—Neuroscience and Meditation for Daily Life. Liam shares his remarkable journey from a career in private equity to traveling throughout Asia to study meditation and ultimately becoming a Buddhist monk. What began as a temporary commitment to deepen his meditation practice became a three-year transformation that completely reshaped how he viewed happiness, purpose, and the mind.Liam explains how neuroscience and meditation can work together to help us understand our thoughts, emotions, expectations, and patterns of suffering. He explores the Buddhist concept of “dukkha,” why unmet expectations can create mental turmoil, and how learning to observe the mind can help us cultivate greater peace and resilience. He also shares why meditation and taking action aren't opposites, and how mindfulness can become a way of living rather than simply something we practice while sitting in silence.Mike and Liam dive into the importance of surrendering to outcomes, letting go of attachment, living with intention, and creating a “fit mind” while still pursuing meaningful goals in everyday life. Liam also opens up about why he ultimately chose to leave monastic life and bring the lessons he learned as a monk back into the world.Liam holds a B.A. from Yale University and an M.S. in Applied Neuroscience from King's College London and has contributed to meditation research at Harvard Medical School and Massachusetts General Hospital.This episode offers a thought-provoking look at meditation, neuroscience, inner peace, expectations, and what it truly means to train the mind for a better life.Website-www.fitmind.org https://www.instagram.com/fitmind/?hl=en
Dr K is a psychiatrist, Harvard Medical School instructor, co-founder of Healthy GamerGG, Twitch streamer and a YouTuber. Why do so many young men feel stuck? From porn and gambling to video games, distractions and instant gratification seem harder to escape than ever. So how do you break free from the habits holding you back? And can you find a healthy balance between enjoying the moment and building a more fulfilling life? Expect to learn what actually happens to your brain when you gamble, watch porn and play video games, why so many men are addicted to these vices, what prediction markets are doing to the minds of the younger generation, if AI therapy is actually good enough for most people's problems, what everyone got wrong about the Lindsay Clancy case and much more… Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices
She calls it puberty in reverse. It can last a decade. And most husbands have no idea it's happening. LIVE WITH DR. HIRSCH, THURSDAY, OCTOBER 8TH. She is joining the Front Row Dads community for a live session with Q&A on how men can support the women in their lives through menopause. Free for members, and a limited number of guest passes for everyone else. Details at frontrowdads.com/menopause Dr. Heather Hirsch is board-certified in internal medicine, founded the Menopause and Midlife Clinic at Brigham and Women's Hospital, taught at Harvard Medical School, and has treated thousands of women through perimenopause and menopause. She flew to Austin for this one because, in her words, most of the conversation about menopause happens with women, and it's the men who share a bed, a marriage, and a family with them who never get the briefing. This is that briefing. She defines the terms every husband should know, explains what actually happens as the hormones flicker out like a failing light bulb, and walks through what it does to sleep, mood, memory, weight, skin, and sex. Then the practical half: how to bring it up without saying "this explains everything," why tracking symptoms beats blood work, the bedroom at 65 degrees, why so many women see five to seven doctors before the right diagnosis, and what real treatment looks like. Her story is the first 20 minutes. The practical breakdown starts at 19:56. Find a trained clinician: menopause.org or heatherhirschdirectory.com Her books: Unlock Your Menopause Type and The Perimenopause Survival Guide Follow her: @heatherhirschmd Want a taste of what Front Row Dads is actually like? We run a live Brotherhood Experience most months. Jon and a few other dads, 60 minutes on Zoom, and a real conversation about how fatherhood is actually going. It's not a webinar, and you won't leave drained. On any given week, most dads give support and never get any. That's what this hour is for. It's free, and the next date and your seat are both at frontrowdads.com/experience
Today, I am honored to connect with Dr. Zaldy Tan, a geriatric medicine and memory disorder specialist whose research career has centered on the Framingham Heart Studies Offspring Cohort. Dr. Tan currently directs Cedar Sinai's memory and healthy aging programs, after previously leading the memory clinic at Beth Israel and Harvard Medical School. His book, Age Proof Your Mind, translates his clinical and research background into a practical framework for people trying to assess and protect their own cognitive trajectory. In our conversation, Dr. Tan explains why middle age is the old age of youth and the youth of old age. We discuss common symptoms of memory issues and those that are reversible. We explore the Framingham Offspring Study and its impact on brain health over time, looking at the effects of sleep, depression, vitamin deficiencies, alcohol, loneliness, and nutrition, and Dr. Tan shares the three Ds, dementia, delirium, and depression- the red flags he sees in his clinical practice, explains how he helps prepare caregivers for caring for loved ones with neurocognitive memory loss, and discusses late-stage issues, medications, blood-based biomarkers, and the role of genetics in brain health. Stay tuned for a truly fascinating discussion with Dr. Zaldy Tan. IN THIS EPISODE, YOU WILL LEARN: The importance of being sensitive to how your memory changes over time Various factors that could contribute to memory problems The profound effect alcohol has on the brain and neurologic function How social isolation can increase the risk of dementia in future years Dr. Tan discusses the Framingham Offspring Study and the links between metabolic dysregulation and brain MRI markers of brain aging. How the 3 Ds, delirium, dementia, and depression, can overlap The red flags in a patient's history that lead Dr. Tan to believe there may be a more serious issue What care partners should be aware of when a family member is experiencing dementia The importance of protecting sleep and maintaining consistent sleep patterns for those with memory problems How genetic testing is incorporated into Dr. Tan's care model Bio: Dr. Zaldy Tan is the Director of the Memory & Healthy Aging Program at Cedars-Sinai Medical Center, which U.S. News & World Report ranked in 2024 as the best hospital on the U.S. West Coast and among the top hospitals in the country. He holds the Carmen & Louis Warschaw Endowed Chair in Neurology and is a professor at the David Geffen School of Medicine, University of California, Los Angeles. Dr. Tan was the founding director of the Memory Disorders Clinic at Harvard Medical School/Beth Israel Deaconess Medical Center. Dr. Tan performs aging and dementia research covered by The New York Times, Time, CNN, The Wall Street Journal, NPR, The Washington Post, The Chicago Tribune, Reuters, ABC News, and NBC News. He regularly speaks at major national and international conferences and is the author of Age-Proof Your Mind and What to Remember When You Are Forgetting. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Zaldy Tan Dr. Tan at Cedars Sinai (Los Angeles) On Instagram Dr. Tan's book, What to Remember When You Are Forgetting, is coming out on September 15th, 2026. Pre-order HERE.
Send us Fan MailWe spend roughly a third of our lives in bed. But what if the sheets, pajamas and bedding surrounding your body aren't just making you comfortable - what if they're actually affecting your physiology and your sleep?Today we're going to explore a surprisingly important question: can what we wear - and what we sleep on - actually change the quality of our sleep?Lara Smith is Founder and CEO of LUSOMÉ ( https://lusome.com/ ), an award-winning technical luxury brand that developed moisture-management technology for women's sleepwear and has since expanded into temperature-regulating bedding and other sleep products.Lara's journey into this space began with a deeply personal experience. Her younger sister was diagnosed with breast cancer and experienced debilitating night sweats during treatment. Lara couldn't find sleepwear that was both effective at managing moisture and temperature and something a woman would actually want to wear - so she decided to build it herself.What began as a personal problem became a technology and consumer-products company that has now been selling globally for more than a decade.Lara brings an unusual combination of experience to the conversation. Before founding LUSOMÉ, she spent years in the apparel and retail industry, including senior executive roles overseeing major women's apparel businesses and developing growth strategies for hundreds of millions of dollars in annual sales. She was also a finalist for the Canadian EY Entrepreneur Of The Year award in 2018.But what makes her particularly interesting for us today is what happens when textile technology meets human biology.LUSOMÉ's cooling bedding was recently evaluated in a peer-reviewed study involving researchers from Harvard Medical School's Division of Sleep Medicine and Brigham and Women's Hospital. The study analyzed more than 2,600 nights of sleep and reported an average increase of approximately 26 minutes of sleep per night, improvements in sleep quality, and elimination of night sweats for a subset of participants.So today we're going to go beyond the products and ask some bigger questions:What actually happens to the human body when we overheat during sleep? Can manipulating the tiny thermal environment between our skin and our bedding measurably change sleep? Why are night sweats so common during menopause and certain medical treatments? And could the future of sleep involve intelligent materials and personalized environments that actively respond to our physiology?Lara is also the co-founder of SheWorth, a social-impact brand and mental-health platform focused on women's worth, and hosts The Sweaty Pillow ( https://www.thesweatypillow.com/ ), where she speaks with physicians, researchers and experts in women's health, sleep and longevity.Exclusive 25% off Discount Code for Progress, Potential, And Possibilities community -POTENTIAL25 #SleepScience #SleepHealth #Thermoregulation #Menopause #NightSweats #HotFlashes #WomensHealth #SleepTechnology #SleepBetter #TextileTechnology #Longevity #HealthTechnology #Cancer #CancerTreatment #Innovation #Science #FutureOfHealth #FutureOfSleep #Biotechnology #ProgressPotentialAndPossibilitiesSupport the show
Dr. Joyce Maguire Pavao, Ed.D., LCSW, LMFT is a returning guest.She was the Founder and CEO of Center for Family Connections, Inc. in Cambridge and New York, Founder and Director of Riverside After Adoption Consulting and Training, PACT (Pre/Post Adoption Consulting and Training, and Pavao Consulting and Coaching. Dr. Pavao has done extensive training, both nationally and internationally. She is a lecturer in Psychiatry at Harvard Medical School, and she has consulted to various public and private child welfare agencies, adoption agencies, schools, and community groups, as well as probate and family court judges, lawyers, and clergy. Additionally, she has worked closely with individuals and families touched by adoption, foster care, and other complex blended family constructions. She has developed models for treatment, and models for training, using her systemic, intergenerational, and developmental framework, The Normative Crises in the Development of the Adoptive Family. Her book, The Family of Adoption, has received high acclaim. Dr. Pavao has received many awards and honors, including the Children's Bureau/U.S. Department of Health and Human Services Adoption Excellence Award for Family Contribution (2003) and the Congressional Coalition on Adoption award for Angels in Adoption (2000).Music by Corey Quinn
Show notes: (0:00) Intro (1:04) Dr. Srini Pillay's journey from South Africa to Harvard and brain research (4:50) Why the brain and body should be viewed as one connected system (9:32) Emotional suppression, vitality, and physical health (12:35) Why your brain needs periods of unfocused thinking (15:40) Mindsets linked to inflammation, health, and longevity (18:24) Burnout, vitality, and discovering your ideal self (21:06) Autonomy, relationships, motivation, and living longer (23:16) Growth mindset and training your brain to see possibilities (25:30) How beliefs and expectations can change the brain (27:29) Optimism, awe, connection, resilience, and self-transcendence (29:43) Changing your identity to improve creativity and problem-solving (31:37) Visualization and the science behind the law of attraction (35:30) Rewriting the story of your past (39:02) How hostility and stress may affect the body (41:50) The CIRCA method for calming stress and anxiety (46:12) Walking, napping, daydreaming, and doodling for better thinking (48:09) Why understanding your ideal self may be the most important step (48:57) Where to follow Dr. Srini Pillay and learn more (50:48) Outro Who is Dr. Srini Pillay? Dr. Srini Pillay is a Harvard-trained psychiatrist, brain researcher, author, executive coach, and technology entrepreneur whose work focuses on the connection between mindset, brain health, performance, and longevity. He completed his psychiatry residency at McLean Hospital and spent 17 years conducting brain-imaging research, while also directing programs focused on anxiety and panic disorders. He formerly served as an Assistant Professor of Psychiatry at Harvard Medical School. Today, Dr. Pillay is Chief Medical Officer and Co-Founder of Reulay, an AI-driven digital therapeutics company, and Founder and CEO of NeuroBusiness Group. His current work explores psychogenic longevity, including how thoughts, emotions, stress, and mindset may influence healthspan and well-being. He is also the author of Life Unlocked, Your Brain and Business, and Tinker Dabble Doodle Try, and has worked with leaders and organizations around the world. Connect with Dr. Srini: Website: https://drsrinipillay.com/ LinkedIn: https://www.linkedin.com/in/drsrinipillay IG: https://www.instagram.com/drsrinipillay/ FB: https://www.facebook.com/SriniPillayMD/ Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram
Get your hand-picked playbook here: https://www.figuringout.co/pdf/fo-562Check out Lifespan and get 50% off all Lifespan memberships with code RAJ2026: https://lifespan.com/Guest Suggestion Form: https://forms.gle/bnaeY3FpoFU9ZjA47Disclaimer: This video is intended solely for educational purposes and opinions shared by the guest are his personal views. We do not intent to defame or harm any person/ brand/ product/ country/ profession mentioned in the video. Our goal is to provide information to help audience make informed choices. The media used in this video are solely for informational purposes and belongs to their respective owners.(00:00) - Intro(02:48) - Reversing Age: The World's First Age-Reversal Technology(08:10) - Why Every Organ Ages Differently & What Biological Age Really Means(16:36) - The Mouse Experiments That Proved Age Reversal Is Possible(23:58) - The Breakthrough Discovery That Reversed Aging & Cured Glaucoma(32:30) - Why Your DNA Breaks 20,000 Times a Day(48:33) - His Fasting Protocol(1:04:13) - What Is NAD?(1:08:05) - Why Children Don't Get Alzheimer's or Cancer: The Epigenome Advantage(1:24:50) - Can Aging Damage Be Reversed? Spine Repair & Immune Aging(1:29:04) - What Determines Aging & Why He Went Vegan(1:31:45) - What's Better: Running or Strength Training?(1:40:33) - GLP-1 Drugs, AI Drug Discovery & the Future of Disease-Free Aging(1:51:10) - Ayurveda Meets Science: What Ancient Medicine Got Right(1:53:11) - Good Stress vs. Bad Stress: When Hormesis Goes Too Far(2:00:10) - 5 Habits Linked to 14 Extra Years of Healthy Life(2:05:30) - Daily Habits That Actually Work: Steps, Standing & Diet(2:12:07) - Supplements: What He Takes & What Young People Should Avoid(2:20:51) - What's One Thing People Should Change in Their Lives to Make It Better?(2:22:00) - What's the Cost of Becoming David Sinclair?(2:24:00) - BTS(2:24:45) - OutroIn today's episode, we sit down with Dr. David Sinclair, A.O., Ph.D., Longevity Scientist and Professor of Genetics, Harvard Medical School, to understand the science of aging and whether we can actually slow it down.Follow Dr. David Sinclair Here:Instagram: https://www.instagram.com/davidsinclairphd/X: https://x.com/davidasinclair?lang=enAbout Raj ShamaniRaj Shamani is an Entrepreneur at heart that explains his expertise in Business Content Creation & Public Speaking. He has delivered 200+ speeches in 26+ countries. Besides that, Raj is also an Angel Investor interested in crazy minds who are creating a sensation in the Fintech, FMCG, & passion economy space.To Know More,Follow Raj Shamani On ⤵︎Instagram @RajShamani https://www.instagram.com/rajshamani/Twitter @RajShamani https://twitter.com/rajshamaniFacebook @ShamaniRaj https://www.facebook.com/shamanirajLinkedIn - Raj Shamani https://www.linkedin.com/in/rajshamani/About Figuring OutFiguring Out Podcast is a Candid Conversations University where Raj Shamani brings raw conversations with the Top 1% in India.
A surprisingly uplifting conversation on aging, sickness, and death. Plus: why you get happier as you get older, hard-earned tips for handling tough diagnoses, and how to think about AI in your health care. Atul Gawande, MD, MPH, is a surgeon, author, and public health innovator. He holds the Fish Chair in Surgery at Brigham and Women's Hospital. He is the Samuel O. Thier Professor of the Practice of Surgery at Harvard Medical School and Professor of the Practice at Harvard T.H. Chan School of Public Health. Dr. Gawande was Assistant Administrator for Global Health at USAID from 2022-2025. He is a longtime writer for The New Yorker and has written four books: Complications, Better, The Checklist Manifesto, and Being Mortal. In this episode we talk about: Why the best doctors ask patients what matters before choosing treatment The simple question that reveals what makes life worth living Why patients who get less aggressive care sometimes live longer His father's answer to "what's worth living for" changed three times Why staying independent and staying safe often pull in different directions Research showing people get emotionally calmer, not sadder, as they age What happened when the U.S. shut down its global health aid programs Why he sees AI as a helpful second opinion, not a replacement, for doctors Get the 10% with Dan Harris app here Sign up for Dan's free newsletter here Follow Dan on social: Instagram, TikTok Subscribe to our YouTube Channel Additional Resources: Being Mortal, the book Being Mortal, the documentary This episode is sponsored by: Warby Parker: Buy one pair of glasses and get 20% off any additional pairs at WarbyParker.com/HAPPIER — and using our link helps support the show. #WarbyParker #ad BetterHelp: Sign up and get 10% off at BetterHelp.com/HAPPIER. Notion: Learn more about how Notion can support your business, at notion.com/happier To advertise on the show, contact sales@advertisecast.com or visit https://advertising.libsyn.com/10HappierwithDanHarris
Can chocolate actually protect your heart or are we giving candy a health halo it doesn't deserve? Dr. Howard Sesso from Brigham and Women's Hospital and Harvard Medical School joins Chuck Carroll to reveal what the landmark COSMOS trial discovered about cocoa extract, cardiovascular disease and cognition. The randomized clinical trial included more than 21,000 participants. One secondary outcome showed a 27% reduction in cardiovascular disease death among participants assigned to cocoa extract. However, the primary cardiovascular outcome did not reach statistical significance. Dr. Sesso explains what both findings mean and why the distinction matters. You'll also learn: Whether dark or bitter chocolate is automatically healthier The difference between cocoa, cacao and cocoa flavanols Why cocoa powder and cacao nibs may be better choices Cocoa's effects on inflammation and cognition Flavan-3-ols sources and why they matter Why the findings still need to be replicated Exam Roomie of the Week Charles Shryock Make a gift to support The Exam Room Podcast and the life-changing work of the Physicians Committee. All gifts of $20 or more receive a mention on the show. Gifts of $100 or more receive an exclusive Exam Room Podcast tote!
The Context of White Supremacy welcomes the return of Dr. Julie M. Stamm. Classified as a White Woman and brandishing a doctorate in anatomy and neurobiology from the Boston University School of Medicine, Dr. Stamm conducted research at the Boston University Chronic Traumatic Encephalopathy Center and the Psychiatry Neuroimaging Laboratory at Harvard Medical School, Brigham and Women's Hospital. We first spoke with Dr. Stamm in 2023 just days after Damar Hamlin was nearly killed on the football field. We discussed her new book, The Brain On Youth Sports: The Science, The Myths & The Future. Gus learned a lot from Dr. Stamm and applied her teachings to future programs and thinking about tackle football and brain health. The recent happenings with CTE research, including a report suggesting that at least 25% of NFL players have this type of brain impairment, motivated Gus to check in with Dr. Stamm one more. Many in the tackle football industry did not view this news with excitement. In fact, this in conjunction with news that 24-year-old Marshawn Kneeland, who played 18 total NFL games all for the Dallas Cowboys before taking his own life at the end of 2025, suffered from Stage 1 CTE made many question if it's possible to play tackle football “safely.” #TheCOWS17Years #JulieStamm #ChrisJohnson #NFL #TackleFootball #CTE #Concussion #GlobalWhiteSupremacy #DamarHamlin #WhiteBallGames #MarshawnKneeland #DallasCowboys Call-In Number: 720.716.7300 Code: 564943#
Sarah Russell picked up a phrase at her new job at Anthropic: a "non-regrettable primitive." It's how she describes the kind of infrastructure she thinks Anthropic should be building in healthcare, and it says a lot about how one of the most closely watched companies in health AI is positioning itself. In this episode, Steve talks with Sarah Russell, MD healthcare and life sciences lead at Anthropic. This conversation comes as Anthropic heads toward what's shaping up to be one of the most anticipated IPOs in years.We cover:What Anthropic is doing in healthcareWhy HIPAA is struggling to keep up with AI agents Where she thinks AI will change care first (it's not where you'd expect!)The two very different bars regulators are weighing AI against, and why the choice matters more than most people realizeThe one piece of advice from her father that still shapes how she builds teams, and what she tells doctors nervous about a career in medicine nowAbout our guest:Sarah currently works on healthcare and life sciences projects at Anthropic. She is particularly passionate about research that explores how to make Claude safer and less confidently wrong. Prior to Anthropic, she was at Google X, an innovation hub at Alphabet, where she learned to lead teams of smart engineers building ML- and LLM-based products. Seeing the earliest version of Google's Med-PaLM summarize a patient chart made her excited about healthcare technology all over again. Prior to Google, she was a CMIO in the VA system and a start-up founder. A graduate of Harvard College and Harvard Medical School, Sarah did her internal medicine residency at MGH and completed an MBA at Wharton. She still practices part-time in Urgent Care at Stanford, where she is an Assistant Professor.⸺
What does it really mean to take charge of your health? Lucy McBride MD, believes it involves much more than tracking your numbers. Good health is also about understanding the less measurable parts: what’s happening in your life, your relationships, stress, habits, emotional patterns, and your history. Dr. Lucy McBride, a primary care physician and author of Beyond the Prescription: A Doctor's Guide to Taking Charge of Your Health, joins us to discuss how to become a more informed, proactive annd empowered partner in your own healthcare. We discuss the difference between control and agency, why your bio contains important health data, the “patient personality” each of us brings into the doctor’s office, when health tracking helps (and when it doesn’t) and why the transition to retirement can make structure, movement, social connection, and daily routines even more important. Lucy McBride, MD joins us from Washington DC. _________________________ Bio Dr. Lucy McBride is a board-certified internist who has practiced primary care medicine in Washington, DC, for over two decades. She is a native Washingtonian who attended the National Cathedral School before earning her undergraduate degree from Princeton University. She graduated with honors from Harvard Medical School and earned a Master’s Degree in Pharmacology as a Fulbright Scholar at the University of Cambridge, U.K. She completed her internship and residency in Internal Medicine at Johns Hopkins Hospital. Dr. McBride has become a nationally recognized voice in healthcare transformation and patient empowerment. She believes that health is not a checklist or an outcome, but rather a lifelong process that requires awareness, acceptance, and agency over what you can change. She is the author of Beyond the Prescription: A Doctor’s Guide to Taking Charge of Your Health (Simon & Schuster, August 2026), which offers a five-step framework for patients to reclaim agency over their health. The book has been praised for bridging the gap between conventional medicine and holistic wellness, refusing false binaries and empowering patients to make informed decisions. She writes the widely-read medical newsletter Are You Okay?, which reaches over 39,000 subscribers weekly with evidence-based guidance on navigating mental and physical health in tandem. She also hosts the top-rated podcast Beyond the Prescription. Dr. McBride’s work has been published in The Atlantic, The Washington Post, and USA Today. She is a frequent media commentator, appearing on NPR, CNN, MSNBC, Morning Joe, and PBS NewsHour, where she provides evidence-based medical advice and advocates for a more comprehensive approach to healthcare. Her mission extends beyond individual patient care to transforming the healthcare system itself. She believes that empowering individual patients creates systemic change—and that primary care relationships, enhanced by technology but centered on human connection, are the foundation of sustainable healthcare transformation. Dr. McBride lives in Washington, DC with her husband and three children. _______________________ For More on Lucy McBride Beyond the Prescription: A Doctor’s Guide to Taking Charge of Your Health Beyond the Prescription Podcast You can learn more about Dr. McBride here. You can subscribe to her free newsletter here. _______________________ Other Retirement Podcasts You’ll Love Eat Your Ice Cream – Ezekiel Emanuel, MD, PhD What Matters Most – Diane Button Inside The Healthcare Heist – Jordan Grumet, MD _______________________ Wise Quotes On Agency “People often don’t realize how much agency they have over their health…When we stop fighting unwinnable battles, we then open up brain space, time, energy to then fight the battles we want to be fighting. That’s the birthplace of agency.” On Your Story & Your Health “We love collecting data. Cholesterol levels, blood pressure, body mass index, right? All the things we can measure in a test tube. But it turns out the most important data is actually something only you have access to. It’s your biography. Your biographic data matters, I would argue, even more than your biometric data, and your biographic data informs your biometric data.” On Self-Compassion “When I was able to connect the dots between her story, which is very relevant, those biographic pieces of data from when she was a kid, and her blood sugar readings, her blood sugar readings that go up when she’s stress eating and she’s not taking care of herself, that’s me handing power to the patient. That’s me saying, “Look, you have more agency than you think.” It’s not that understanding the relationship between childhood traumas and your diabetes, the knowledge alone isn’t enough, but it’s to say that there’s no GLP-1, there’s no shot, there’s no medication that’s going to practice self-compassion for you and for you to make peace with your body and to, and to feed your body the way it wants to be fed.” On Taking Charge “The idea of being the CEO of Your Health is being someone who can understand at its core where you have agency and where you do not, and knowing the difference. It sounds a lot like the Serenity Prayer, right? It’s basically the wisdom to understand where you can execute in your life, habit changes, relationship changes, whether the relationships to food or alcohol or other people or your retirement, and where you have to cede control, like you’re aging, you have a genetic predisposition to a disease you don’t like, you have medical conditions that you’d rather not have. Because it turns out that the best CEOs in the world are people who don’t try to control everything. They also don’t outsource everything to somebody else. They know the difference between where they have control and where they don’t, and then they ask for help. My book is essentially a guide to making sense of your health in a more nuanced way because you do have more control than you think.” ____________________________ About The Retirement Wisdom Podcast There are many podcasts on retirement, often hosted by financial advisors with their own financial motives, that cover the money side of the street. This podcast is different. You'll get smarter about the investment decisions you'll make about the most important asset you'll have in retirement: your time. About Retirement Wisdom I help people who are retiring, but aren't quite done yet, discover what's next and build their custom version of their next life. A meaningful retirement doesn't just happen by accident. Schedule a call today to discuss how the Designing Your Life process created by Bill Burnett & Dave Evans can help you make your life in retirement a great one — on your own terms. About Your Podcast Host Joe Casey is an executive coach who helps people design their next life after their primary career and create their version of The Multipurpose Retirement.™ He created his own next chapter after a 26-year career at Merrill Lynch, where he was Senior Vice President and Head of HR for Global Markets & Investment Banking. Joe has earned Master's degrees from the University of Southern California in Gerontology (at age 60), the University of Pennsylvania, and Middlesex University (UK), a BA in Psychology from the University of Massachusetts at Amherst, and his coaching certification from Columbia University. In addition to his work with clients, Joe hosts The Retirement Wisdom Podcast, ranked in the top 1% globally in popularity by Listen Notes, with over 2 million downloads. Business Insider recognized Joe as one of 23 innovative coaches who are making a difference. He's the author of Win the Retirement Game: How to Outsmart the 9 Forces Trying to Steal Your Joy. _________________________ The views and opinions expressed by guests on The Retirement Wisdom Podcast are those of the guests and do not necessarily reflect the policy or position of the host or Retirement Wisdom, LLC. The Retirement Wisdom Podcast covers the non-financial aspects of retirement. From time to time we may invite guests who discuss other aspects of retirement planning, solely for educational purposes. Listeners are advised to consult qualified financial and/or medical professionals on those matters.
In this podcast, Wade T. Iams from the Greco-Hainsworth Centers for Research Tennessee Oncology, Nashville, TN, USA and Narjust Florez form the Dana-Farber Cancer Institute and the Harvard Medical School, Boston, MA, USA discuss safety considerations with MET TKI treatment for patients with METex14 skipping NSCLC. This podcast is published open access in Targeted Oncology and is fully citeable. You can access the original published podcast article through the Targeted Oncology website and by using this link: https://link.springer.com/article/10.1007/s11523-026-01242-z. All conflicts of interest can be found online. Open Access: This podcast is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The material in this podcast is included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ This Lifespan episode explores how what we eat shapes how we age - from inflammation and blood sugar to the trillions of microbes living in our gut. Dr. Sinclair explains how diet affects key biological processes tied to metabolism, health, and longevity. Dr. Sinclair breaks down what sugar does inside the body, including glycation - the process by which sugar attaches to proteins and disrupts their function. The conversation also explores why inflammation rises with age, how the gut microbiome changes over time, and why our ability to sense and respond to nutrients can decline as we get older. Most importantly, Dr. Sinclair explains what we can do about it - from reducing dietary drivers of inflammation and excess sugar to supporting gut health and the nutrient-sensing pathways linked to longevity. __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research. The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
George Santos bets against the house, Harvard Medical School pays an arm and a leg, and one woman's literal nightmare leaves a bat taste in our mouths. This week, BenDeLaCreme and Gareth Reynolds open up the Lovett or Leave It advice line. I Don't Care, I Lovett it lifts a glass to heels, hotel bathtubs, and Matthew Morrison's 9/11 infidelity cabaret. And then bob's your uncle, it's time to say goodbye with a round of Second Thoughts.Hate listening to ads? Become a Friends of the Pod subscriber for ad-free episodes of Pod Save America, Pod Save the World, Lovett or Leave It, Runaway Country, Offline with Jon Favreau, and more—plus exclusive content, including bonus episodes of Pod Save America. Subscribe now at crooked.com/friends, on Apple Podcasts, or through the Pod Save America YouTube channel.You can request a transcript by emailing transcripts@crooked.com. Include the podcast name, episode title, and air date. Please allow 48 hours for delivery.
Dr. Jared Cooney Horvath has lectured at Harvard, Harvard Medical School, and the University of Melbourne, and has worked with more than 150 schools around the world. In this episode he gives five findings from brain science that change what you do Monday — starting with the one most of us have backwards. Memory isn't built by how you put information in. It's built by how often your students pull it back out. This episode originally aired in 2019 and comes in at number seven in our countdown of the top 10 episodes of the first 1,000. In this episode, you'll learn: - Why rereading notes doesn't build memory, and what to do instead - Why students can't read your slides and listen to you at the same time - The attention threshold, and how to reset it every 10 to 15 minutes - How to find the story behind a fact so the fact sticks - Why facts have to come before skills, demonstrated with a cricket match you won't understand a word of Full show notes, resources, and the complete transcript: https://www.coolcatteacher.com/e987 If this one made you rethink something you've been doing for years, share it with a teacher who needs it.
Fear, Evil, and the Need for God's TruthIn this episode, we examine the powerful promise of Psalm 91:5: "Thou shalt not be afraid for the terror by night, nor for the arrow that flieth by day." As believers face a world filled with disturbing headlines and moral confusion, God's Word reminds us where true security is found.We discuss shocking examples of human wickedness, including the Harvard Medical School morgue scandal involving the theft and illegal sale of donated body parts, and reflect on what such acts reveal about the fallen nature of mankind. We also touch on ongoing debates surrounding the remembrance of September 11 and the importance of truth, justice, and accountability in public life.Through a biblical lens, this episode explores the reality of evil, the condition of the human heart, and the hope found in God's righteous judgment and sovereign protection. Join us as we seek wisdom, courage, and faith in uncertain times.Scripture Focus: Psalm 91:5Key Topics:God's protection in troubling timesFear versus faithThe reality of evil in societyThe Harvard body-parts scandal9/11 remembrance and public discourseGod's justice and the need for salvationTune in for a thought-provoking biblical perspective on today's headlines and the enduring truth of God's Word.The Voice in the Wilderness does not endorse any link or other material found at buzzsprout.More at https://www.thevoiceinthewilderness.org/
In this episode of Shoulders Down, Leah sits down with Jackie Liu, a third-year medical student at Harvard Medical School and co-lead of advocacy for Medical Students for Size Inclusivity (MSSI), to explore weight stigma in medicine and what it takes to create more size-inclusive healthcare (HINT: GLP-1s are NOT the answer).Jackie shares their personal journey from struggling with disordered eating and body image to discovering fat studies and weight-inclusive approaches to health. Together, Leah and Jackie unpack how weight bias can become embedded in medical training, the ways fat phobia shows up in healthcare settings, and the incredible work MSSI is doing to advocate for more equitable care.They also discuss the rise of GLP-1 medications and why informed consent and patient autonomy are essential components of size-inclusive medicine. This conversation offers a hopeful look at the medical students and future providers working to challenge weight stigma from within the healthcare system.You'll hear about:Jackie's journey from struggling with body image and disordered eating to discovering fat liberation and weight-inclusive careHow weight bias and fat phobia can become embedded in medical education and healthcare cultureWhy Medical Students for Size Inclusivity exists and how the organization is working to create changeThe barriers to providing truly weight-inclusive healthcareGLP-1 medications, informed consent, and the importance of protecting patient autonomyMentioned in this Episode:
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and longevity scientist - and co-host Matthew LaPlante explore why we age, how aging begins long before its visible signs appear, and what we can do to slow aspects of cellular aging. They break down key drivers - or “hallmarks” - of aging, including mitochondrial dysfunction, stem cell exhaustion, and declining communication between cells, and explain how these changes can affect energy, inflammation, and the body's ability to repair itself. They also explore practical strategies including exercise, cold exposure, and molecules such as berberine, curcumin, metformin, and resveratrol, alongside emerging research into mitochondrial replacement and stem cells. Along the way, they tackle intriguing questions: When does biological aging begin? Why can identical twins age at different rates? Why does energy decline with age? And what can we do today to stay healthier for longer? __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research. The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Jacques Kpodonu, a cardiac surgeon at Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA, and Assistant Professor of Surgery at Harvard Medical School, Boston, Massachusetts, USA, about the use of intraoperative artificial intelligence (AI) copilots in robotic cardiac surgery. Chapters 00:00 Intro 01:29 JANS 1, Pediatric Shunts 02:34 JANS 2, Ruptured Aortic Arch Repair 03:43 JANS 3, Pulm Valve Replacement Guidelines 04:43 JANS 4, Stress in the OR 05:48 JANS 5, Adjustable Pulm Valve Feasability 07:21 Video 1, OBAS Simulator 08:11 Video 2, Routine LAVV Augmentation 08:41 Video 3, Transaortic Alfieri Stitch 09:51 Dr. Kpodonu, Robotics AI Copilot 26:41 TAVR Heart Team Webinar They discussed building data sets for future robotic autonomy, the process of training AI copilots for robotic surgery, and utilizing these systems for teaching and coaching. The conversation also covered creating operative reports with AI copilots and robotics in low-resource countries. Furthermore, they explored the costs of robotics, the role of automated tasks in assisting surgeons, the development of physical AI in humanoid robots, utilizing AI to create annotations, and how surgeons can become actively involved in the field of AI. Joel also highlights recent JANS articles on a systematic review and meta-analysis of cryopreserved and antibiotic-preserved saphenous vein homografts versus polytetrafluoroethylene grafts for systemic-to-pulmonary artery shunts in pediatric patients; single-stage repair of ruptured aortic arch with coarctation using dual perfusion strategy; the 2026 expert consensus document on timing, indications, and options for pulmonary valve replacement in children with repaired tetralogy of Fallot; the role of self-regulation and leadership in dealing with pressures in the operating room; and one-year outcomes of novel size-adjustable pulmonary valve US early feasibility study. In addition, Joel explores redefining the two-patch technique for complete AV canal repair, transaortic Alfieri stitch for mitral valve repair, modified Bentall, and hemiarch repair, and an episode of The Atrium podcast featuring host Dr. Alice Copperwheat speaking with Dr. Traves Crabtree about the Oral Board AI Simulator (OBAS). Before closing, Joel highlights upcoming events in CT surgery. JANS Items Mentioned The Battle of the Shunts: A Systematic Review and Meta-Analysis of Cryopreserved and Antibiotic-Preserved Saphenous Vein Homografts Versus Polytetrafluoroethylene Grafts for Systemic-to-Pulmonary Artery Shunts in Pediatric Patients Single-Stage Repair of Ruptured Aortic Arch With Coarctation Using Dual Perfusion Strategy The Society of Thoracic Surgeons / World Society for Pediatric and Congenital Heart Surgery / European Congenital Heart Surgeons Association 2026 Expert Consensus Document on Timing, Indications, and Options for Pulmonary Valve Replacement in Children With Repaired Tetralogy of Fallot Performance Under Pressure: The Role of Self-Regulation and Leadership in Dealing With Pressures in the OR Novel Size-Adjustable Pulmonary Valve US Early Feasibility Study: One-Year Outcomes CTSNet Content Mentioned The Atrium: Oral Board AI Simulator Redefining the Two-Patch Technique for Complete AV Canal Repair: Routine LAVV Augmentation Alfieri Stitch for Mitral Valve Repair, Modified Bentall, and Hemiarch Repair Other Items Mentioned The TAVR Heart Team in 2026: Navigating the CMS Decision | CTSNet Webinar Oral Board AI Simulator CTSNet Innovation Video Competition Career Center CTSNet Events Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
Patients looking to combat skin aging? I mean, who isn't? This week, we're joined by Dr. Jack Arbiser as he walks us through the latest science of skin aging. Listen in as he discusses aging processes, intermittent fasting, exercise, and how to augment mitochondrial function. Each Thursday, join Dr. Raja and Dr. Hadar, board-certified dermatologists, as they share the latest evidence-based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com. Jack L. Arbiser, MD, PhD is a key opinion leader in dermatology, with over 300 publications focused on novel treatments for skin diseases. He earned a BS/MS in Organic Chemistry from Emory University and an MD/PhD from Harvard Medical School. He is a cofounder of Accuitis Neuroscience, which focuses on novel therapies to prevent Alzheimer's disease, and of Takeviv, an anti-aging supplement. He sees patients at Metroderm/UDP.
Dr. Tony Nader is a Harvard- and MIT-trained neuroscientist, physician, and internationally recognized expert in consciousness, human development, and mind-body health. He serves as the global leader of the Transcendental Meditation® organizations, guiding their educational, health, and humanitarian initiatives in more than 100 countries worldwide. Dr. Nader earned his medical degree from the American University of Beirut, completed advanced clinical and research training at Harvard Medical School and Massachusetts General Hospital, and received a Ph.D. in Brain and Cognitive Science from the Massachusetts Institute of Technology (MIT). His research has explored neuroscience, neurochemistry, neuroendocrinology, stress physiology, consciousness, and human potential. A New York Times bestselling author, Dr. Nader writes and speaks on the relationship between consciousness, health, emotional well-being, resilience, and human flourishing. His work bridges modern science with deeper questions about awareness, connection, and the full development of human potential. His latest book, The Power of Caring, explores why so many people today feel emotionally exhausted despite their desire to remain compassionate, connected, and engaged—and offers a science-based framework for cultivating resilience, deep rest, emotional balance, and sustainable caring in an increasingly overwhelmed world. https://www.youtube.com/@DrTonyNader https://www.instagram.com/drtonynader/ https://www.instagram.com/vedicsciencebydrtonynader/ https://www.facebook.com/DrTonyNader His new book and The Power of Caring website: https://www.thepowerofcaringbook.com/
HEADLINES: Four men have been interviewed by Victoria Police detectives this week as part of investigations into the sexual assault allegations linked to the Sydney Swans AFL club. Police are investigating after a man was shot dead in Sydney’s west in what detectives believe was a targeted daylight attack. Consent advocate Chanel Contos has told National Press Club that big tech is radicalising young men into harmful sexual behaviour, and is pushing for a ban on social media algorithms. The world is on track to exceed 1.5 degrees of global warming within years, according to a new UN report. So it turns out we’ve all been drinking water wrong. And good news for animal lovers about the New Zealand kākāpō. New research suggests the real damage in contact sports might not be happening on game day, but during training, and it's raising urgent questions for anyone with a kid on a footy field this weekend. On this episode of The Quicky, we look at the degenerative brain disease increasingly turning up in Australian football codes, from AFL and AFLW to soccer, and why doctors believe the cumulative hits from years of junior sport could matter more than any single big hit. We hear from leading neurologist Dr Rowena Mobbs on what parents and clubs can actually do about it, and why the answer isn't pulling your kid off the field.Important concussion advice from Dr Rowena Mobbs, neurologist at Mater Hospital Sydney: - Keep brain health front of mind.- Carefully observe the athlete if a concussion is suspected and follow the protocols.- Know the red flags that may indicate a more serious brain injury: Neck pain - Increasing confusion, agitation or irritability - Repeated vomiting - Seizure or convulsion - Weakness or tingling/burning in the arms or legs - Deteriorating conscious state - Severe or increasing headache - Unusual behavioural change - Loss of vision or double vision - Visible deformity of the skull - Loss of consciousness. - If you see these signs, seek emergency care." For more information, check out The Australian Concussion Guidelines for Youth and Community Sport. For anyone concerned about CTE, ConneCTErs Australia run a national support service, visit this link. GET IN TOUCHGot a story, news tip-off, feedback or dilemma?Send us a voice note or email us at thequicky@mamamia.com.au HELPFUL LINKS: Become a Mamamia subscriber and get an all-access pass to everything we make, including exclusive podcasts and early listening, subscriber-only articles, monthly giveaways and our home workout app, MOVE. Get access to Very Peri, Mamamia's exclusive perimenopause series, for just $59. 25 world-leading experts, over 20 on-demand sessions, available now. We’ve sorted through the noise so you don't have to. Go to veryperi.com.au today. You hot? Same. CREDITSHost: Georgie Page Audio Producer: Scott Stronach Group Executive Producers: Georgie Page and Tamsin Rose Check out The Quicky Instagram here and our TikTok here Discover more Mamamia podcasts here Did you know some of our shows are now in video on the Apple Podcast app? Make sure your phone is up to date and check it out here! Mamamia acknowledges the traditional owners of the land on which we have recorded this podcast.Become a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.
Today, BeMo Experts discusses Harvard Medical School personal statement examples, breaking down what makes these essays stand out and providing actionable insights to help you craft a compelling narrative for your own application. Like the podcast? Schedule a Free Initial Consultation with our team: https://bemo.ac/podbr-BeMoFreeConsult Don't forget to subscribe to our channel and follow us on Facebook, Instagram, and Twitter for more great tips and other useful information! YouTube: https://www.youtube.com/c/BeMoAcademicConsultingInc Facebook: https://www.facebook.com/bemoacademicconsulting Instagram: https://www.instagram.com/bemo_academic_consulting/ Twitter: https://twitter.com/BeMo_AC TikTok: https://www.tiktok.com/@bemoacademicconsulting
What if we could reverse the damage caused by age-related disease instead of simply managing its symptoms? In this episode of Entrepreneur Rx, host John Shufeldt sits down with Daniel Oliver, CEO and Co-founder of Rejuvenate Bio, a Jetstream Venture Fund portfolio company, to explore the science behind age-related disease, the potential of gene therapy, and what it takes to turn groundbreaking research into treatments for both animal and human health. This success has lead to one of the leading crowdfunding equity campaigns.Rejuvenate Bio grew out of George Church's lab at Harvard Medical School, where research into the biology of aging opened the door to a bigger question: instead of treating age-related diseases one at a time, could we target the underlying changes that drive them? Daniel explains the company's work across heart failure, kidney failure, metabolic dysfunction, and epigenetic reprogramming. Daniel and John also dig into Rejuvenate Bio's strategy of developing therapies for both companion animals and humans. Its most advanced program is targeting mitral valve disease in dogs, while its human program moves toward clinical development. Daniel explains why dogs can be a powerful model for age-related disease and how animal health may provide a faster path for translating aging science into real-world therapies. Beyond the science, Daniel shares his unconventional journey from mechanical engineering and aerospace to Harvard Business School, entrepreneurship, and biotech. He and John discuss why breakthrough ideas often emerge at the intersection of different disciplines, and they get candid about the pressure of startup life and why the “never sleep, always hustle” mentality can make founders worse leaders. About Daniel Oliver: Daniel Oliver is Co-founder and CEO of Rejuvenate Bio, a spinout of George Church's Lab at Harvard Medical School focused on targeting the drivers of age-related disease through novel gene therapies. Prior to Rejuvenate Bio, Daniel was awarded a Blavatnik Fellowship, during which he co-founded Voxel8. Voxel8 was named one of the top innovations at CES and one of the 50 most innovative companies by MIT Technology Review. Daniel received his MBA from Harvard Business School and holds degrees in Mechanical Engineering and Business from the California Institute of Technology. About Rejuvenate Bio: Rejuvenate Bio is a George Church spinout with backing from Merck and leading VCs developing one-time gene therapies that target the root causes of age-related disease, beginning in companion animals and expanding to humans. The company was the first to demonstrate lifespan extension using epigenetic reprogramming and is advancing a breakthrough cardiovascular platform built around a single-dose therapy that restores youthful levels of a critical age-declining soluble protein. Preclinical data show reversal of heart damage and durable metabolic reset, positioning the program as a potential long-term alternative to chronic therapies such as GLP-1s. About Xcellerant Ventures: Xcellerant is a venture capital firm investing in innovative companies across healthcare, technology, defense, and other emerging industries.About Jetstream Venture Fund: Jetstream is an interval fund that provides investors access to venture opportunities across multiple stages, with a $5,000 minimum and no carried interest. Disclosure for Jetstream: Investors should carefully consider the investment objectives, risks, charges, and expenses of the Fund before investing. The prospectus contains this and other information about the Fund and can be obtained by emailing jetstream@sweaterfunds.com or by visiting www.jvf.vc. Please read the prospectus carefully before investing. About Pitch Deck Analysis: Pitch Deck Analysis reviews your deck like an investor would, with scoring, feedback, and recommendations on what to improve before you pitch. Use code EntrepreneurRx for a free Founder Pack with five free runs.
What happens when life throws something at you that you just can't undo? A diagnosis. A loss. A moment that changes everything. In this episode of the MindBodySpace Podcast, Dr. Juna sits down with Dr. Ellen O'Donnell — clinical child psychologist at Mass General Hospital and assistant professor at Harvard Medical School — to talk about easily missed symptoms of Diabetes and possible screening for this disease in the near future. She also talks about what resilience really looks like when there's no going back.This isn't about "bouncing back." It's about finding your new normal and building on your strengths to move forward.What you'll learn:Why resilience is NOT about returning to who you were beforeHow to stop guilt from blocking your ability to heal and adaptWhat a "new normal" actually looks like — and how to find yoursPractical tools for parents, caregivers, and anyone navigating a major life changeHow to build resilience in your kids even through the hardest momentsWhether you're a parent, a caregiver, or someone facing your own unexpected chapter — this episode will give you real, science-backed strategies to keep moving forward.
In this week's podcast we'll be hearing a lot about exams - the bane of many doctor's training lives, exams that determine your future are scattered through medicine and can cause a huge amount of anxiety and stress… John McLachlan, professor of medical education at the University of Lancashire, has carried out four reviews of medical exams. He explains what happens to the people who have been marked wrongly, why he thinks re-sits should be done differently, and why multiple choice questions are still in use. Over the Summer there have been extensive protests from the young people of India, the “Cockroach Janta Party” has led demonstrations across the country, sparked by allegations of cheating in India's “NEET” exams - the federal tests taken by applicants to India's medical training. Rohan Krishnan, orthopaedic surgeon in Delhi, and chief of the Federation of All India Medical Association, and Kathir Karuppiah, a house surgeon in Tamil Nadu, join us to explain where India's medical admissions tests are failing students. We'll also hear about new research into Chronic Traumatic Encephalopathy in NFL players. Daniel Daneshvar is associate professor at Harvard Medical School, and he and his co-authors have examined the brains of 338 former players, with the goal of determining how many of them died with CTE neurodegeneration. He joins us to explain his findings, and what it means for competitive sports players and others who play contact sports. Reading list: “Cockroach” victory: India's education minister resigns over medical exam scandal linked to 12 suicides Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21
The world's largest HIV-focused meeting took place in late July — and as ever, the science came fast and furious, to the tune of more than 2,500 presentations. When a conference is this large, distilling what's likely to have the greatest import for HIV clinicians in the U.S. is one heck of a tall order. Thankfully, our guest this month is very much up to the task: Paul Sax, M.D., a professor of medicine at Harvard Medical School, the clinical director of the Division of Infectious Diseases at Brigham and Women's Hospital in Boston, and the editor-in-chief of Clinical Infectious Diseases. Support the pod by reading the transcript on TheBodyPro: https://www.thebodypro.com/podcast/hiv/future-hiv-care-paul-sax-international-aids-conference-aug-2026 Read more from Dr. Sax at NEJM Voices: https://voices.nejm.org/browse/voices-series/paul-sax Or at his personal Substack, PaulSaxMD: https://paulsaxmd.substack.com/ The host and executive producer of this podcast is Myles Helfand; our senior production manager is Alina Mogollon-Volk; our senior producer is Lizzie Warren; and our audio editor is Kim Buikema. Special thanks to Alina Mogollon-Volk this month for her audio editing assistance.
In this Huberman Lab Essentials episode, my guest is Dr. Chris Palmer, MD, a board-certified psychiatrist and Assistant Professor of Psychiatry at Harvard Medical School. We explain how nutrition and metabolism directly affect mental health, including the biological mechanisms underlying these effects. We also discuss how carbohydrate restriction, ketogenic diets and fasting can improve mood, energy, and, in some cases, treatment-resistant psychiatric conditions. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Timestamps (00:00:00) Chris Palmer (00:00:20) Personal Story, Nutrition & Mental Health (00:05:28) Treatment-Resistant Mental Disorders & Low-Carbohydrate Diet (00:07:32) Sponsor: Eight Sleep (00:08:51) Ketogenic Diet & Schizophrenia Success Story (00:12:20) Nutrition for Mental Disorders, Ketosis, Highly Processed Foods (00:15:13) Epilepsy & Ketogenic Diet, Fasting; Mitochondrial Benefits (00:21:14) Sponsor: BetterHelp (00:22:15) Mitochondria Functions, Mental Disorders (00:28:05) Mitophagy, Autophagy, Longevity & Calorie Restriction (00:33:12) Sponsor: AG1 (00:34:25) Carbohydrate Restriction, Depression Treatment (00:37:23) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
This is The Briefing, a daily analysis of news and events from a Christian worldview.On today's edition of The Briefing, Dr. Mohler discusses Meta's lawsuit settlement over social media harm to young people, Harvard Medical School's director caught in black market body part scandal, and the CIA Director's rare and undisclosed trip to Moscow.Part I (00:13 – 09:23)Meta Agrees to Settle Massive Lawsuit Over Social Media Harm to Young People: Parents Will Now Bear More Power and Responsibility in How Their Children Access Social MediaMeta to Pay Up to $17.1 Billion in Landmark Settlement Over Social Media Addiction Claims by The New York Times (Cecilia Kang and Eli Tan)Part II (09:23 – 21:08)Why Is This Unspeakably Wrong? Medical School Morgue Director Caught in Black Market Body Part ScandalHarvard settles stolen body parts lawsuits. Here’s what happened by USA Today (Saleen Martin)Part III (21:08 – 26:44)CIA Director Makes a Rare and Undisclosed Trip to Moscow: Is This an Indicator That Putin is About to Attack NATO?CIA director's secretive visit to Moscow stirs mystery by The Washington Post (Alex Horton, Michael Birnbaum, Warren P. Strobel and Joyce Sohyun Lee)The CIA might just have given an alarming signal that Putin is about to attack Nato by The Telegraph (Tom Tugendhat)Sign up to receive The Briefing in your inbox every weekday morning.Follow Dr. Mohler:X | Instagram | Facebook | YouTubeFor more information on The Southern Baptist Theological Seminary, go to sbts.edu.For more information on Boyce College, just go to BoyceCollege.com.To write Dr. Mohler or submit a question for The Mailbox, go here.
Dr David Sinclair is a geneticist, professor at Harvard Medical School, and author. Can human aging actually be reversed? What happens if we treat aging as a disease rather than an inevitability? And how close are scientists to turning age-reversal experiments into medicines that could radically extend our lives? Expect to learn how scientists can reset the age of cells without causing cancer, whether resveratrol and NAD supplements actually work, why three meals a day plus snacks might be marketing, the best exercise protocol for longevity, whether GLP-1s are legitimate longevity drugs, and much more... Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get a free bottle of D3K2, an AG1 Welcome Kit, and more when you first subscribe at https://ag1.info/modernwisdom Get up to 20% off Timeline's leading longevity and cellular health supplement at https://timeline.com/modernwisdom Get 160+ lab tests for just $365 and save an extra $25 at https://functionhealth.com/modernwisdom Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices
In this podcast repost, we rediscover the work of Pediatric Gastroenterologist Dr. Alessio Fasano from the Massachusettes General Hospital Department of Pediatric Gastroenterology. In this conversation, we discussed the research on Intestinal Permeability, Microbiomes and MIS, Multi Inflammatory Syndrome in Children . Dr. Fasano also directs the Mucosal Immunology and Biology Research Center and is associate chief for Basic, Clinical and Translational Research. Under his leadership, investigators are studying the molecular mechanisms of autoimmune disorders including celiac disease, and other-gluten-related disorders. He has been named visiting professor of pediatrics at Harvard Medical School. He authored the groundbreaking study in 2003 that established the rate of celiac disease at one in 133 Americans. Widely sought after by national and international media, Dr. Fasano has been featured in hundreds of interviews including outlets such as The New York Times, The Wall Street Journal; National Public Radio; CNN; Bloomberg News, and others. He recently co authored an excellent book with Susie Flaherty called Gut Feelings. I highly recommend you purchase and read this book. It is an encyclopedia of information regarding gut health, the microbiome and much more. Enjoy my conversation with Dr. Fasano, Dr. M
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ This episode explores why humans are biologically built to move and what happens to the aging process when we don't. Drawing on evolutionary biology and the latest research, Dr. Sinclair traces physical activity back millions of years, explaining how humans evolved for endurance, why modern sedentary life creates a profound mismatch with our biology, and how exercise activates ancient cellular pathways involved in repair, resilience, metabolism, and longevity. Dr. Sinclair breaks down what happens inside the body when we exercise, including the molecular responses that help us adapt to stress and influence the brain, immune system, metabolism, cardiovascular health, and even the way our cells age. He also tackles some of the biggest questions in exercise science: Can exercise offset sitting all day? Do we compensate for calories burned during exercise? Why did humans evolve such extraordinary endurance? And could exercising with others provide benefits beyond physical fitness? From our evolutionary past to the molecular machinery inside our cells, this episode reveals why movement is so deeply embedded in human biology – and why staying active may be one of the most powerful ways to keep that biology working as we age. __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research. The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
HOUR 3 (08/21) - Gary & Shannon stay on the wild police chase as the suspect somehow stops for gas mid-pursuit, survives an attempted citizen’s arrest and is finally tackled after taking off on foot. Then #SwampWatch turns to Jill Biden defending Joe Biden’s performance and reopening an uncomfortable political conversation ahead of the midterms. Plus, #NNNYNTK brings a squid-truck spill, Florida chaos involving a bitten ear and 28 bags of fentanyl, Fat Bear Week, a Harvard Medical School organ scandal and one very mysterious place to hide cash.See omnystudio.com/listener for privacy information.
Four reasons I love homeschooling.(As a second generation homeschooler.)Christian Instruction Academic RigorFamily Connection Flexible Lifestyle NOTE: Every family is different. Homeschooling isn't right for everyone!! What's good for one family might not be the best for another!! It is so sweet to enjoy the freedom to seek the Lord for guidance in what in each specific circumstance.
For many young women diagnosed with breast cancer, some of the most important decisions they will ever make happen within days of hearing the words, "You have cancer." While treatment planning begins immediately, patients may also be faced with urgent questions about fertility, future family-building, and preserving options they may not have expected to think about so soon. These conversations often happen during a period of fear, uncertainty, and information overload, leaving many patients feeling overwhelmed and unprepared. In this episode, I'm joined by Dr. Ann Partridge, Vice Chair of Medical Oncology and Chief Clinical Strategy Officer at Dana-Farber Cancer Institute, where she also serves as co-founder and director of the Program for Young Adults with Breast Cancer. A professor at Harvard Medical School, Dr. Partridge is a leading breast oncologist and researcher whose work focuses on improving care and outcomes for young adults with breast cancer. Together, we discuss how breast cancer treatment can affect fertility, why these conversations need to happen early, the options available today, and how patients can make informed decisions while balancing the urgency of cancer treatment with hopes and plans for the future. We also reinforce the hopeful message that having children after breast cancer is often possible - and that preserving future options begins with having the right conversations early. Most importantly, this episode is a reminder that patients deserve information, support, and compassionate guidance when facing life-changing decisions at diagnosis. Resources Mentioned in This Episode For additional information and support, visit the Young and Strong Program at Dana-Farber Cancer Institute, which offers resources and practical guides for young adults with breast cancer, including those who are newly diagnosed, in treatment, or in survivorship, as well as caregivers. The program also provides trusted information about fertility preservation, pregnancy after breast cancer, and breastfeeding. The information shared on Dear Cancer, I'm Beautiful is for educational and informational purposes only and is not intended as medical advice. Always consult your physician or qualified healthcare provider regarding your individual medical care and treatment decisions. The views and opinions expressed by guests are their own and do not necessarily reflect those of Cancer Fashionista. Thank you to Daiichi Sankyo and Novartis for making this episode of the Signature Series possible.
This episode is sponsored by Gilead Sciences. Gilead had no involvement or input in the podcast content. Gilead is working to transform how cancer is treated. We are innovating with next-generation therapies, combinations, and technologies to deliver improved outcomes for people with cancer. From antibody drug conjugates and small molecules to cell therapy-based approaches, our portfolio and pipeline assets are creating new possibilities for people with cancer.Dr. Sara Tolaney, Chief of the Division of Breast Oncology at Dana-Farber Cancer Institute, returns to Patient From Hell to explain the ASCENT-04/KEYNOTE-D19 study, the phase 3 trial she led as principal investigator, and what it changes for people living with metastatic triple-negative breast cancer.For years, the most effective drugs for metastatic TNBC were only available after first-line chemotherapy had already failed. The problem, as Dr. Tolaney puts it plainly, is that many patients never reach a second line of treatment at all. ASCENT-04 asked whether moving an antibody-drug conjugate to the front, paired with immunotherapy, would change that. Median progression-free survival improved from 7.8 months to 11.2 months, and treatment responses lasted significantly longer.UPDATE: Since this recorded conversation, the FDA has acted on the data discussed in this episode. On May 22, 2026, Datopotamab Deruxtecan was approved for first-line metastatic TNBC in patients who are not candidates for immunotherapy. On June 24, 2026, Sacituzumab Govitecan was approved for first-line use both as a single agent and in combination with pembrolizumab for PD-L1-positive disease (CPS ≥10). Consult with your care team for the most recent indications and availability of these treatment options.00:00 The trial that moves the best drugs first 00:31 Welcome back, Dr. Sara Tolaney 00:40 What ASCENT-04 set out to solve 02:00 Why many patients never reach second-line treatment 02:50 What PD-L1 status means for your treatment 04:12 The result: 7.8 to 11.2 months 05:29 What is an antibody-drug conjugate (ADC)? 06:33 Why TROP-2 is the target in triple-negative breast cancer 07:24 How immunotherapy works: taking the brakes off the T cell 09:01 Who was eligible for the trial 10:05 What "controlling" cancer actually means 11:44 Progression-free survival vs. duration of response 13:37 Dr. Tolaney reconsiders: what ASCENT-03 showed 15:51 How trial data reaches your oncologist's office 18:21 The testing checklist after a metastatic diagnosis 19:59 First-line treatment options today 22:27 The new paradigm: ADCs as the first-line backbone 23:51 What comes second line 25:29 Why tumor sequencing matters: somatic BRCA, TMB, trials 27:24 Twenty years of change in triple-negative breast cancer 29:28 Advice for a newly diagnosed patientSara M. Tolaney, MD, MPH is Chief of the Division of Breast Oncology and Associate Director of the Susan F. Smith Center for Women's Cancers at Dana-Farber Cancer Institute, and Associate Professor of Medicine at Harvard Medical School. She trained at Princeton University, UC San Francisco, Johns Hopkins University, and Dana-Farber Cancer Institute, and holds a Masters in Public Health (MPH) from Harvard University. She serves on the National Cancer Institute (NCI) Breast Cancer Steering Committee and is Vice Chair for Late-Stage Development in Breast Cancer for the Alliance for Clinical Trials in Oncology. She was principal investigator of ASCENT-04.
On this episode of The Opportunist, Cedric Lodge spent nearly three decades as a trusted morgue manager at Harvard Medical School - until he was caught stealing body parts from donated cadavers and selling them online to collectors across the country. The episode traces how a man entrusted with the remains of people who gave their bodies to science turned that access into a black market, betraying hundreds of grieving families in the process.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Every night, while you're asleep, your brain runs a cleaning cycle that clears out the kind of toxic buildup linked to Alzheimer's and dementia. And, with age, most of us sleep less. We are shortchanging the benefits without ever realizing how much control we actually have over sleeping longer, and better.Dr. Rebecca Robbins is an Assistant Professor in Sleep Medicine at Harvard Medical School and an Associate Sleep Scientist at Brigham and Women's Hospital, where her research spans sleep's relationship to cognitive function, cardiometabolic health, and long-term brain health. She's published more than 100 peer-reviewed studies, co-authored Sleep for Success!, and her work is exactly the kind of research most of us never hear about until someone frames it the way she does here.In this conversation, you'll explore:Why sleep really does shift around age 38 to 40, and what that shift does and doesn't mean for youThe neuroscience discovery of the brain's overnight "wash cycle," and what Dr. Robbins's own eight-year study found about sleep complaints and dementia riskWhy jumping your bedtime back an hour almost never works, and the fifteen-minute method that doesThe at-home test Jonathan didn't realize he'd already run on himselfThe "sleep divorce" reframe one of Dr. Robbins's patients calls a "sleep marriage," and what it means for couplesIf you've quietly decided your sleep is just what it is at this stage of life, this conversation will change what you think is actually possible tonight.You can find Rebecca at: Website | Instagram | Episode TranscriptNext week, we're sitting down with Tommy Wood to talk about what the research actually shows about keeping your brain sharp across decades, including which levers matter most, what's mostly noise, and what you can realistically start tomorrow, whether you're 45 or 65. Be sure to follow Good Life Project wherever you get your podcasts so you don't miss any upcoming episodes!Check out our sponsors and resources: Visit Our Sponsor Page Hosted on Acast. See acast.com/privacy for more information.
The Digital Delusion: How Classroom Technology Harms Our Kids’ Learning–and How to Help Them Thrive Again by Jared Cooney Horvath PhD Med. https://www.amazon.com/dp/B0GPR5NXSM Educator and neuroscientist Dr. Jared Cooney Horvath reveals why digital tools in school consistently undermine learning—and what parents, teachers, and schools can do to push back with purpose. Our children are struggling. Schools, once alive with human connection, are now dominated by screens and digital tools. The result is unmistakable: declining performance, fractured attention, and the slow erosion of rigorous thought. For the first time in recent history, children are falling behind previous generations on many key measures of cognitive development. In The Digital Delusion, neuroscientist and educator Dr. Jared Cooney Horvath reveals how the widespread use of laptops, tablets, and classroom software is undermining how children learn and develop. Drawing on decades of research, he provides practical tools for families to reassess device use at home, equips educators with the means to restore attention-rich learning environments, and helps schools make smarter decisions about technology. He exposes and dismantles the central myths driving the EdTech movement and lays out a clear path for putting people—not programs—back at the center of education. This is not a call to reject technology. It's a call to reclaim real learning. About the author Jared Cooney Horvath (PhD, MEd) is a neuroscientist, educator, and best-selling author who specializes in human learning and brain development. He is the creator of The Learning Blueprint, an international award-winning program helping educators and students understand how learning actually works. Jared has conducted research and taught at Harvard University, Harvard Medical School, and the University of Melbourne, and has worked with more than 1,000 schools around the world. He is the author of six books, has published over fifty research articles, and his work has appeared in The New Yorker, The Atlantic, The Economist, Harvard Business Review, and PBS's NOVA. He currently serves as Director of LME Global, an organization dedicated to bringing cutting-edge brain and behavioral science to educators, students, and communities.
Jeremy Pauley's basement discovery exposed a nationwide human remains trafficking network involving stolen body parts, an Arkansas mortuary, and the morgue at Harvard Medical School. In Part 1 of The Body Trade, we follow the investigation from Pauley to Candace Chapman Scott, Matthew Lampi, Katrina Maclean, Joshua Taylor, Denise Lodge, and Harvard morgue manager Cedric Lodge, uncovering how donated human remains were stolen, bought, sold, and shipped across the country, and how the investigation ultimately led to federal convictions.Watch the full episode on YouTube:▶ https://bit.ly/TheoriesOfTheThirdKindYTSupport the show + unlock bonus episodes:
Patreon/Supercast Special Release – Bonus – Inside Mentalization-Based Treatment: Borderline & Narcissistic Personality Disorders (308) This is a sneak peek of our 2nd episode with Robert Drozek – available only on our Premium Supercast and Patreon platforms. For as little as $5/month you can have access to special releases like this one, first-to-know about upcoming events and discounts and an ad-free feed. Click here to join & finish the episode!! What is mentalization—and how can therapists put it into practice? In this more clinical deep dive, Robert Drozek explores Mentalization-Based Treatment (MBT) and how strengthening our ability to understand our own and others' inner experiences can support the treatment of borderline and narcissistic personality disorders. Sue and Robert explore the common breakdowns in mentalizing, the power of curiosity over certainty, and practical strategies clinicians can use to help clients build greater emotional awareness, empathy, and connection. “The hallmark of mentalization is curiosity.” – Robert Drozek Time Stamps for Bonus – Inside Mentalization-Based Treatment: Borderline & Narcissistic Personality Disorders (308) 01:20 – What is Mentalization? 02:56 – The origins of Mentalization-Based Treatment (MBT) 08:07 – Curiosity vs. certainty: What healthy mentalizing looks like 12:43 – When thoughts feel like facts: Psychic equivalence 18:14 – Certainty in Borderline Personality Disorder 19:34 – Certainty in Narcissism 20:58 – The “not-knowing” stance in MBT 26:00 – How Mentalization-Based treatment actually works 32:32 – MBT vs. DBT: What's the difference? 35:11 – How therapists can incorporate Mentalization into practice 42:25 – Identifying Mentalizing blind spots About our Guest – Robert P. Drozek, LICSW Robert P. Drozek, LICSW is the clinical director of the Mentalization-Based Treatment Clinic at McLean Hospital in Belmont, Massachusetts. He is a teaching associate in the Department of Psychiatry at Harvard Medical School, specializing in the treatment of borderline personality disorder, narcissistic personality disorder, and post-traumatic stress disorder. He is author of the new book, Mentalization: Utilizing reflection to heal from borderline personality disorder—the first book for the general public about mentalization-based treatment. Resources for Bonus – Inside Mentalization-Based Treatment: Borderline & Narcissistic Personality Disorders (308) Download page – Free worksheets and handouts from the book Mentalization Coach App – The first mobile app for mentalization and MBT, adapted from my new book Mentalization-based Treatment for Pathological Narcissism – Handbook Mentalization-based Treatment for Personality Disorders – A practical guide Cambridge Guide to Mentalization-based Treatment Anna Freud Centre – The worldwide training hub for mentalization-based treatment (MBT) NPD Basic – A free guide to narcissistic personality disorder MBT Boston – An organization that Robert co-founded that offers training and supervision to clinicians across the world in MBT MBT USA – A consortium of MBT providers and organizations in the United Robert’s faculty page at McLean Hospital Instagram: @RobertDrozek Mentalization book – Facebook page Get your copy of Mentalization: Utilizing Reflection to Heal from Borderline Personality Disorder here! Looking for our Upcoming Events? Click here!! Our Beyond Attachment Styles course is available NOW! Learn how your nervous system, your mind, and your relationships work together in a fascinating dance, shaping who you are and how you connect with others. Earn 6 Continuing Education Credits – Available at Checkout Online, Self-Paced, Asynchronous Learning with Quarterly Live Q&A’s – Next Q&A Coming September 2026!
David Sinclair, AO, PhD, is a longevity scientist, Professor of Genetics at Harvard Medical School, author of the book "Lifespan: Why We Age—and Why We Don't Have To," and host of the "Lifespan" podcast.www.youtube.com/c/davidsinclairpodcast www.simonandschuster.com/books/Lifespan/David-Sinclair/9781501191978 https://lifespan.com https://davidasinclair.com Perplexity: Download the app or ask Perplexity anything at https://pplx.ai/rogan. Visit https://superpower.com/rogan for $20 off your membership. This video is sponsored by BetterHelp. Visit https://BetterHelp.com/JRE Learn more about your ad choices. Visit podcastchoices.com/adchoices
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We're building the world's largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and longevity scientist – details how to exercise for a longer, healthier life. Drawing on the latest research, Dr. Sinclair explains why exercising for longevity isn't the same as training for peak athletic performance – including how much exercise you really need, which types matter most as you age, and whether more exercise is always better. He also breaks down the key fitness metrics for longevity – including VO2 max, grip strength, resting heart rate, and heart rate variability (HRV) – and why cardiorespiratory fitness may predict mortality more strongly than smoking, diabetes, or hypertension. Lastly, Dr. Sinclair tackles some of the most common questions about exercise science: What's the best time of day to work out? Should you drink coffee beforehand? Should men and women train differently? How should exercise change as you age? Whether you're just getting started or already exercise regularly, this episode offers a practical, evidence-based guide on what to do to stay healthier for longer. __________________________________________ Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years. Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings). If you'd like to learn more or try these tools: ○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN ○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN ○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN __________________________________________ Legal & Medical Disclaimers The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider. You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program. The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ. From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual. Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research. The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
Borderline and narcissism are often misunderstood—this episode separates myth from science. Robert Drozek explores the science behind borderline and narcissistic personality disorders, separating common myths from current research. Together, he and Sue discuss attachment, trauma, genetics, parenting, evidence-based treatments, and why understanding these often misunderstood conditions can bring greater compassion, hope, and healthier relationships. “Borderline is driven by a need to reconnect.” – Robert P. Drozek, LICSW Time Stamps for Challenging Personalities: Understanding Borderline & Narcissism with Robert Drozek (307) 04:14 Understanding Borderline Personality Disorder 09:25 Exploring narcissism: Definitions and types 13:29 Vulnerable vs. grandiose narcissism 18:56 The Role of Trauma in Personality Disorders 22:25 Parenting styles and their impact on narcissism 27:14 Identifying narcissism in relationships 33:34 Treatment approaches for Borderline Personality Disorder 36:45 Challenges in treating Narcissistic Personality Disorder 45:26 Navigating relationships with narcissistic individuals About our Guest – Robert P. Drozek, LICSW Robert P. Drozek, LICSW is the clinical director of the Mentalization-Based Treatment Clinic at McLean Hospital in Belmont, Massachusetts. He is a teaching associate in the Department of Psychiatry at Harvard Medical School, specializing in the treatment of borderline personality disorder, narcissistic personality disorder, and post-traumatic stress disorder. He is author of the new book, Mentalization: Utilizing reflection to heal from borderline personality disorder—the first book for the general public about mentalization-based treatment. Resources for Challenging Personalities: Understanding Borderline & Narcissism with Robert Drozek (307) MBT Boston – An organization that Robert co-founded that offers training and supervision to clinicians across the world in MBT MBT USA – A consortium of MBT providers and organizations in the United Robert’s faculty page at McLean Hospital Instagram: @RobertDrozek Mentalization book – Facebook page Get your copy of Mentalization: Utilizing Reflection to Heal from Borderline Personality Disorder here! Please support our sponsors – they keep our podcast free and accessible to all! SimplePractice is an all-in-one EHR that is HIPPA compliant, HITRUST certified and built specifically for therapists. If you are ready to simplify the business side of your practice, now is a great time to try SimplePractice. Start with a 7-day free trial, then get 50% off your first three months. Just go to SimplePractice.com/TU to claim the offer. Beyond Attachment Styles – Deepening Security in Yourself and Fostering More Secure Relationships Course available NOW! Everyone’s heard of attachment styles – but you likely don’t know how much the popular press gets wrong and what the science actually says about how to improve your relationships long term (including how we relate to ourselves). This course is for anyone wanting to more deeply understand attachment (styles vs patterns), unconscious defense activation patterns, implicit scripts… and most importantly, what to do once you do get activated! Online, Self-Paced, Asynchronous Learning with Quarterly Live Q&A’s! Earn 6 Continuing Education Credits – Available at Checkout. As a listener of this podcast, use code BAS15 for a limited-time discount. Or read Marriott & Kelley’s critically-acclaimed book, Secure Relating: Holding Your Own in an Insecure World (HarperCollins,2023) for the most in-depth experience of learning about Secure Relating. Therapists love it, but it’s accessible to everyone. If you aren’t interested in the background science, just start at Part 2 and we will be talking directly to you – it’s fun! You are invited! OK for those of you who refer others to the pod, use it professionally or consider yourself nerdy and just love this stuff, hello, you are our people! Join our exclusive community to get exclusive bonus content, early access to training opportunities, and an ad-free, private podcast feed. It’s this warm community that allows us to donate half of all corportate profits to mental health access for marginalized peoples. Sign up for our premium Neuronerd plan!! Click here!!
A Harvard-trained internal medicine doctor with 40 years of practice just admitted something most physicians would never say out loud. What changed his mind? In this episode, Lance Wallnau sits down with Dr. Carlos, board-certified in internal medicine and a Harvard Medical School graduate, to walk through the stem cell regenerative therapy results he's now witnessing firsthand. In 18 months, he dropped from five diabetes medications to three, eliminated both blood pressure medications entirely, and watched his wife's debilitating knee pain disappear the day after treatment, after six conventional solutions had done nothing. This isn't theory. These are results from a doctor who tested it on himself first. In this episode: * Why Dr. Carlos says some conditions labeled "chronic" may have natural solutions worth exploring * How he personally reduced five diabetes meds to three and stopped both blood pressure medications * How stem cells follow the body's own inflammation signals to find the root cause, not just the symptom * A severe tremor patient who woke up after three days with dramatically improved motor function * What happens when the body is given the natural building blocks it needs to repair itself If you've been managing a condition for years and wondering if there's more to explore, this conversation is for you. Podcast Episode 2200: What 40 Years in Medicine Didn't Teach This Harvard Doctor | don't miss this! Listen to more episodes of the Lance Wallnau Show at lancewallnau.com/podcast