Podcasts about AMR

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Best podcasts about AMR

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Latest podcast episodes about AMR

Another Mother Runner
Miles of Books: The Art of Pacing

Another Mother Runner

Play Episode Listen Later Jun 9, 2026 40:19


Anyone feeling rundown or overburdened owes it to herself to listen to this episode about a brand-new book called The Art of Pacing: A Guide to Balancing Short-Term Demands with Long-Term Thriving by Elizabeth Svoboda. A big fan of this 188-page book, Coach Liz Waterstraat details lessons learned from it, including the importance of choosing to rest (couched in the term, “principled dissent”) and why a “struggle phase” when starting a run or kicking off a work project is natural and normal. Discover what it means to “re-story”—and why it can provide clarity and energy.Feisty Fest: Join us from September 18-20, 2026 - https://feisty.co/events/feisty-fest/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Currex: Use code AMR15 for 15% off at https://currex.com/Tifosi Optics: Use code FEISTY2026 for 20% off at https://tifosioptics.com/

Another Mother Runner
Striving for Goals as a Mother—and a Grant That Can Help

Another Mother Runner

Play Episode Listen Later Jun 5, 2026 69:17


For every mother worried she might have to forgo athletic goals due to parenting demands, this episode is for you! In this heartwarming, inspiring episode, hosts Sarah Bowen Shea and Tish Hamilton talk with two mothers who were able to pursue their marathon goals thanks, in part, to a generous grant from For All Mothers+. (Psst, the application deadline is June 10!) One momma completed her first marathon, while the other guest qualified for the Olympic Marathon Trials (!). In the episode:-both runners detail how their marathon dreams became reality-one mom's journey from watching the Olympic Marathon Trials on TV to qualifying for them-the importance of the word “and” for women-how running became therapy for a single mom-the sweet finish-line surprise that awaited the first-time marathonerBefore the first guest joins around 12:25, the co-hosts gab about a recent sporty getaway.Watch the episode on YouTubeFeisty Fest: Join us from September 18-20, 2026 - https://feisty.co/events/feisty-fest/Join AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Currex: Use code AMR15 for 15% off at https://currex.com/Tifosi Optics: Use code FEISTY2026 for 20% off at https://tifosioptics.com/

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The New Warehouse Podcast
Warehouse Fulfillment Automation Built for Throughput

The New Warehouse Podcast

Play Episode Listen Later Jun 3, 2026 14:03


Welcome to this episode of The New Warehouse Podcast, where Kevin Lawton speaks with David Scheffrahn live from MODEX 2026 in Atlanta. Representing Ocado Intelligent Automation(OIA), Scheffrahn shares how the company is combining high-density storage, robotic fulfillment, AI-driven orchestration, and autonomous mobile robots to improve warehouse fulfillment automation. The conversation explores Ocado's storage and retrieval system, its fulfillment software platform Ocado IQ, and a new AMR focused on pallet and case fulfillment. Learn more about our sponsor Dexory's Storage Health here. Follow us on LinkedIn and YouTube.Support the show

Another Mother Runner
The Benefits of Walking for Runners with Milica McDowell, DPT

Another Mother Runner

Play Episode Listen Later May 29, 2026 55:23


No matter what speed your forward motion is, you need to listen to this enlightening episode featuring Milica McDowell, DPT, co-author of Walk: Rediscover the Most Natural Way to Boost Your Health and Longevity―One Step at a Time. Along with hosts Sarah Bowen Shea and Molly Williams, Dr. Milica details:the true sweet spot of daily steps (pssst: It's less than 10,000!)the remarkable powers of a 5-minute walk and walking backwardposture tips and walking drillswhy you might want to ditch your weighted vestthe myriad benefits runners can gain by adding walks to their daily routineThe co-hosting duo talk about recent swimming and hiking adventures before Dr. Milica joins around 08:50.Watch on YouTubeJoin AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

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Another Mother Runner
Miles of Books: Inside the Box: How Constraints Make Us Better

Another Mother Runner

Play Episode Listen Later May 26, 2026 32:44


Anyone who believes limited time, options, or resources are holding them back needs to listen to this intriguing episode. Coach Liz Waterstraat shares surprising lessons learned from the hot-off-the-presses book Inside the Box: How Constraints Make Us Better by David Epstein. Realize why more freedom doesn't equal more possibility—or more productive workouts or better race outcomes! Learn how to minimize distractions during workouts to boost focus. And discover if you are a “satisficer” like Sarah or more of a maximizer/satisficer hybrid like Coach Liz.Join AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

Manufacturing Happy Hour
289: Beyond the Hype: How Autonomy Is Scaling Across Critical Industries (LIVE from Pittsburgh)

Manufacturing Happy Hour

Play Episode Listen Later May 26, 2026 56:01


20 years ago, automation was a pipe dream for industrial workers, 10 years ago it existed in research and development labs. Now it's fully operational in warehouses, production facilities and even mines.The companies driving robotics forwards are going one step further than developing smarter AI. They're figuring out how to apply that advanced engineering to ‘gritty' manufacturing – and there are few places that understand that world better than the Steel City.Pittsburgh has become an important ecosystem for developing autonomous technologies, the combination of engineering talent and thriving industrial background has turned it into somewhat of a testing ground for physical AI.Recorded in Pittsburgh, Pennsylvania, this was a special live show in collaboration with the Pittsburgh Robotics Network. Chris is joined by three industry leaders to talk about adopting autonomy in critical industries. Brett Phillips is Chief Revenue Officer and General Council at Hellbender, specializing in on-edge AI hardware development. David Griffin is Chief Sales Officer at Seegrid, manufacturer of autonomous mobile robots. Mike Smocer is CEO of Mine Vision Systems, a mining technology company building real-time digital mapping systems for GPS denied environments.They dig into how autonomy is moving beyond one-off projects, and into fully integrated systems. Brett breaks down how the incorporation of sensors and models are shrinking development timelines for autonomous systems and why Pittsburgh's willingness to ‘get their hands dirty' is key. David explains how advances in perception and control systems have pushed AMRs beyond basic pallet moves into large, complex material moves through busy logistics environments. Mike shares how Mine Vision Systems support vital underground decision making with millions of dollars of impact by replacing manual mapping and tribal knowledge with accurate digital records.For anyone considering where robotics and AI can create value inside their operations, thinking about the intersection between advanced software and manufacturing, or curious why Pittsburgh has become so strong in robotics and autonomy, this episode is a look at how three industry leaders are managing that change today.In this episode, find out: • About the technological advances that shifted autonomy from isolated deployments to a broader ecosystem covering manufacturing, logistics, mining and warehouse operations.• How David explains the evolution of AMRs within lifting, going from limited pallet moves to an all-in-one technology capable of moving any material to any location.• Why mid-tier manufacturers are becoming a major driver of autonomy adoption due to labor constraints and the positive impact of this in regional production environments.• What mining looks like without the implementation of automated systems, Mike discusses highly intelligent operators still using coloured pencils and paper to capture critical underground data.• Mining as a tunnel building process with the constant balance of optimizing extraction with breakage vs. how much time and cost is spent processing the material caused by that breakage.• How Hellbender utilizes their expertise and capability to provide an end-to-end service inhouse, getting their customers to market in a matter of months rather than years.• The role of sensors, on-edge AI, and manufacturing capability in accelerating the production of perception systems that serve as the eyes and ears of the autonomy stack.• What the conversation reveals about Pittsburgh's current position as a robotics hub where engineering talent, institutional history and manufacturing culture are allowing them to go head-to-head with the likes of Silicon Valley.Enjoying the show? Please leave us a review here. Even one sentence helps. It's feedback from Manufacturing All-Stars like you that keeps us going!Tweetable Quotes: • “At the end of the day, we are a software company. The hardware component of our product is essentially a near commodity at this point. It's the navigation systems, the safety systems, the perception systems, the control systems.” – David Griffin • ”There is a transformation involved. There's change management involved. There are workflows that if you disrupt them just because your cool technology solved one little problem, broke 12... There's an approach to developing your technology so that it succeeds not only now, but in the future.” – Mike Smocer• “What's gonna separate us moving forward is the ability to sort of mash this really high-level, very technical engineering with real-world manufacturing. That is where, uniquely, Pittsburgh stands alone.” – Brett Phillips Do you want to connect with other leaders that are moving the needle in manufacturing everyday?Then make sure to join us in the Manufacturing Happy Hour Industry Community on LinkedIn.Apprentice has developed the first AI Agent designed specifically for manufacturing, not adapted from a general model. It connects across your full tech stack, keeps an eye on operations 24/7, and helps automate the mission-critical workflows your team is handling manually today. This isn't “set it and forget it” AI. Your team stays in control of every critical decision, because that's how real manufacturing works.Recommended Resources• Pittsburgh Robotics Network, facilitating commercial business growth and economic development opportunities for the Greater Pittsburgh region's robotics, automation, and vision communities• Seegrid, delivering customized AMR solutions that meet the changing needs of today's manufacturing, logistics, and warehousing facilities• Mine Vision Systems, maximizing efficiency and safety in underground mining operations with real-time 3D mapping technology• HELLBENDER Inc., building mission-critical hardware and software infrastructure for AI-driven perception systems in autonomy, robotics, and industrial applicationsConnect with David, Mike, and BrettDavid Griffin | Mike Smocer | Brett PhillipsMake sure to visit http://manufacturinghappyhour.com for detailed show notes and a full list of resources mentioned in this episode. Stay Innovative, Stay Thirsty.

Another Mother Runner
Three Late-Bloomer Athletes Share Their Stories + Progressions

Another Mother Runner

Play Episode Listen Later May 22, 2026 71:36


No matter what age you were when you became an athlete, you'll enjoy these insightful conversations with three women who didn't discover their sporty side until their 40s. With hosts Sarah Bowen Shea and Tish Hamilton, they share:their “origin” stories of becoming a runner or triathletethe joy of discovering the power of “dirty therapy” (read: trail running)how one runner cut an hour off her marathon finish timeways becoming an athlete changed how they interact in the worlda hilarious—and apt—analogy between running and tooth brushing!Before the first late-bloomer runner hops on around 14:13, Sarah details a recent humbling walk down a marathon-related Memory Lane.Watch on YouTubeJoin AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

Another Mother Runner
Miles of Books: New Novels from Kathryn Stockett, Steven Rowley, Anthony Horowitz, and More

Another Mother Runner

Play Episode Listen Later May 19, 2026 32:48


If you've been eagerly awaiting the latest from the authors of The Help or The Guncle, this is a don't-miss episode! Host Ellison Weist weighs in on Kathryn Stockett's long-awaited novel, and Sarah Bowen Shea details Steven Rowley's new set-in-Palm-Springs book. Ellison also raves about the latest Oprah's Book Club pick. And Sarah goes wild for a novel adaptation on Netflix! The books discussed:The Calamity Club: Kathryn StockettA Deadly Episode: Anthony HorowitzJohn of John: Douglas StuartTake Me with You: Steven RowleyJoin AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

Another Mother Runner
Run or Hike, 10 to 27 Miles: the Grand Traverse Explained

Another Mother Runner

Play Episode Listen Later May 15, 2026 67:53


Attention adventure lovers: Give a listen to this episode about the Grand Traverse, a single-day trail event in Duluth, MN, that lets you choose the distance you cover and at what pace you want to go (hiking or running). Coach Dimity McDowell and three 2025 Grand Traverse participants join hosts Sarah Bowen Shea and Coach Liz Waterstraat to share details and highlights of this epic undertaking, including:-the training involved for a one-day hiking or running event-how hiking 21 miles stacks up to running a half-marathon-essential nutrition and hydration strategies for success-the power of companionship on the trail-the awe-inspiring beauty of hard-won vistasSarah shares a story about a recent “nature event” involving a swarm of rogue honeybees before Coach Dimity joins around 14:00.Join AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr Watch the Episode on YouTube

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Another Mother Runner
Miles of Books: 'Beyond Belief: The Science-Backed Way to Stop Limiting Yourself and Achieve Breakthrough Results'

Another Mother Runner

Play Episode Listen Later May 12, 2026 27:51


This is a must-listen for everyone who needs to get out of their own head and make forward progress. Coach Liz Waterstraat shares wisdom and take-away lessons gleaned from Beyond Belief: The Science-Backed Way to Stop Limiting Yourself and Achieve Breakthrough Results by Nir Eyal with Julie Li. In the conversation with host Sarah Bowen Shea, Coach Liz explains that beliefs aren't facts; the effect anticipation has on physical capabilities; and the importance of stacking small wins. And she drops a scientifically backed shocker about the deleterious effects of hitting snooze!Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr Join AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/

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Another Mother Runner
Mary Cain on Writing, Youth Sports, + Lessons Learned from Running Through Trauma

Another Mother Runner

Play Episode Listen Later May 8, 2026 66:18


This is a must-listen for parents of sporty kids, anyone struggling with an injury, and folks looking for hard-earned wisdom: Running prodigy/phenom Mary Cain, author of the compelling new memoir This Is Not About Running, talks with hosts Sarah Bowen Shea and Tish Hamilton. Interspersed with the hosts expressing anguish at the harassment she endured, Mary details:her reasons for writing a frank, heart-wrenching memoirthe work she's done to recover from her traumahow coaches should treat young athleteswhat she learned from injury that winning couldn't teach herways to advocate for one's health and well beingBefore Mary joins around 12:15, Tish shares her family's history of jaw-dropping longevity.Watch the episode on YouTubeJoin AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

Another Mother Runner
Miles of Books: Three Novels—Including 'Yesteryear'—and One Riveting Non-Fiction (!) Book

Another Mother Runner

Play Episode Listen Later May 5, 2026 27:01


Anyone looking for riveting reads (or audiobooks) need to listen to this episode: Hosts Sarah Bowen Shea and Ellison Weist rave about an incredibly smart, cleverly crafted debut novel; a new novel by a beloved author; a quirky paperback; and the latest brilliant page-turner from a hot writer. Listen all the way through, then dash off to get these books and start reading!Yesteryear: Caro Claire BurkeMore Than Enough: Anna QuindlenThe Road to Tender Hearts: Annie HartnettLondon Falling: Patrick Radden KeefeJoin AMR at the Grand Traverse in Duluth, MN on October 3rd! Use code AMR20 for $20 off when you register at https://feisty.co/events/the-grand-traverse/Follow us on Instagram: https://www.instagram.com/themotherrunner/Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

Take as Directed
Dr. Eli Cahan: “Human beings are wired for stories.”

Take as Directed

Play Episode Listen Later May 4, 2026 40:11


Dr. Eli Cahan explains how he evolved into both a neonatologist and an accomplished, intrepid journalist, inspired by the likes of Atul Gawande and shaped by experiences during the Covid-19 pandemic. It is a balancing act, rushing between fixed medical facilities and airplanes. “We get to bear witness.”  His stories have covered anti-microbial resistance (AMR) among war fighters. An upcoming piece will cover the weakening of prevention and control over polio and the possibility of the reemergence of polio in America. With each, a focus is shaping opinion in Congress. Polio has become a major biosecurity issue and does indeed command attention in Congress and within the administration. The Pitt is fearless in exposing the problems people experience with American health care. At the same time, most health communications are frayed–what to do?

Another Mother Runner
HYROX Races: All the Details Runners Need to Know

Another Mother Runner

Play Episode Listen Later May 1, 2026 76:56


Anyone curious about doing a HYROX race or looking to diversify her running routine needs to listen to this insightful episode. The guests—a HYROX class instructor (Steph Peters), a cyclist/runner taking on her debut HYROX (Kathryn Taylor), and a marathoner who crushed a HYROX doubles race earlier this year (Jackie Minge)—talk with hosts Sarah Bowen Shea and Britany Williams about:What exactly a HYROX race entailsWhy HYROX is more accessible than you might thinkTheories about why HYROX is exploding in popularityWhy runners have an advantage going into a raceWhy one guest chose a certain podcast host to be her doubles partner!Sarah tells tales of her recent jury duty stint (including stair repeats!) before the HYROX instructor hops on around 12:00.Watch the episode on YouTube: https://youtu.be/8z0ZztmcBGIFollow us on Instagram: https://www.instagram.com/themotherrunner/ Feisty Fest: Join us from September 18-20, 2026 - https://feisty.co/events/feisty-fest/ Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

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Another Mother Runner
Miles of Books: 'Revealing: The Underrated Power of Oversharing'

Another Mother Runner

Play Episode Listen Later Apr 28, 2026 26:24


Anyone in search of deeper personal connections or improved athletic performance needs to listen to this episode in which Coach Liz Waterstraat delves into Revealing: The Underrated Power of Oversharing by Leslie John. Coach Liz details why sharing thoughts and feelings helps manage the emotional load of striving; how silence sends a message (which prompts a pickleball anecdote from host Sarah Bowen Shea); and how humanizing it is to share. In true Another Mother Runner style, TMI quips abound in this ep!Follow us on Instagram: https://www.instagram.com/themotherrunner/ Feisty Fest: Join us from September 18-20, 2026 - https://feisty.co/events/feisty-fest/ Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

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Another Mother Runner
Stepping up to Your First—or a New-for-You Distance—Triathlon with Kelly O'Mara

Another Mother Runner

Play Episode Listen Later Apr 24, 2026 52:52


A must-listen episode if you're looking to add a triathlon to your race calendar or to take on a new distance in triathlon: Kelly O'Mara, co-host of the Feisty Triathlon podcast and former editor-in-chief of Triathlete Magazine, shares expert insights on starting and succeeding in triathlon. In a conversation with hosts Sarah Bowen Shea and Molly Williams, Kelly details:how to morph from being a runner to a triathleteovercoming fears + overwhelm about swimmingrealistic race goals (hint: think process, not outcome)the beauty of being part of a triathlon clubmust-have—and can-skip-for-now—gearBefore Kelly joins around 08:15, Molly and Sarah share family updates. Grab Feisty's free beginner sprint triathlon guide.Follow us on Instagram: https://www.instagram.com/themotherrunner/ Feisty Fest: Join us from September 18-20, 2026 - https://feisty.co/events/feisty-fest/ Momentous: Use code AMR for up to 35% off your first order at https://www.livemomentous.com/Wahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr

Microbe Magazine Podcast
Why Your Lab QC Might Be Missing Critical Errors

Microbe Magazine Podcast

Play Episode Listen Later Apr 24, 2026 40:35


Accurate AST results are the backbone of diagnostic stewardship, yet routine quality control (QC) might be missing subtle shifts that skew your hospital's annual antibiogram. By examining a real-world "silent failure" in daptomycin testing, we explore how lab-driven data is essential to the AMR crisis response and why the human eye—and traditional QC bugs—aren't always enough to catch technical drifts. This session breaks down the importance of LIS rules, alert fatigue, and the future of automated susceptibility testing. Guests: Laurel J. Glaser, M.D., Ph.D. Rebekah Dumm, Ph.D. D(ABMM) Links:  Leveraging patient data to detect systematic shifts in daptomycin susceptibility testing associated with reduced prescribing This episode of Editors in Conversation is brought to you by the Journal of Clinical Microbiology and hosted by JCM Editor in Chief, Romney Humphries, Ph.D., D(ABMM) and Elitza (Elli) Theel, Ph.D., D(ABMM).  Visit journals.asm.org/journal/jcm to read articles and/or submit a manuscript. Become an ASM member to receive up to 50% off publishing fees when you publish in JCM or any of the ASM journals. Sign up at asm.org/joinasm.

Finding Genius Podcast
Can AI Unearth New Antibiotics From Ancient DNA? | A Conversation With Prof. César De La Fuente

Finding Genius Podcast

Play Episode Listen Later Apr 18, 2026 23:11


What can the DNA of Neanderthals, woolly mammoths, and ancient proteins tell us about the future of medicine? In this episode, Professor César de la Fuente sits down to discuss his fascinating research goal: using the power of machines to accelerate discoveries in biology and medicine… This conversation explores: The growing global health threat of antimicrobial resistance (AMR). Why ancient DNA and extinct organisms may hold clues for next-generation antibiotics. The role that AI plays in uncovering the genetic data of extinct organisms. What the future of machine biology could mean for human health. Prof. de la Fuente is Presidential Associate Professor at the University of Pennsylvania, where he leads the Machine Biology Group. He is one of the youngest tenured professors in the history of Penn Medicine. He completed postdoctoral research at MIT and earned his PhD from the University of British Columbia. He is widely recognized for pioneering the first computer-designed antibiotic shown to be effective in animal models, which is an achievement that helped launch the emerging field of AI-driven antibiotic discovery. His lab has since identified more than one million potential antimicrobial compounds through computational biology. In addition, Prof. de la Fuente has delivered over 350 invited lectures worldwide, co-authored an influential book on machine learning for drug discovery, secured multiple patents, and published more than 180 peer-reviewed papers in leading journals, including Cell, Science, Nature Communications, PNAS, and Advanced Materials. You can follow Prof. de la Fuente's latest discoveries and research here!

National STD Curriculum
Gepotidacin or Zoliflodacin to Treat Gonorrhea

National STD Curriculum

Play Episode Listen Later Apr 17, 2026 12:57 Transcription Available


Antimicrobial resistant gonorrhea is a global public health concern. This episode discusses two articles evaluating two new antibiotics, gepotidacin and zoliflodacin, to treat uncomplicated urogenital gonorrhea. A retrospective study of WHO global gonococcal antimicrobial surveillance program (GASP) 2019-2022 data is also reviewed. View episode transcript and references at www.std.uw.edu.This podcast is dedicated to an STD [sexually transmitted disease] review for health care professionals who are interested in remaining up-to-date on the diagnosis, management, and prevention of STDs and STIs. Editor and host Dr. Meena Ramchandani is an Assistant Professor of Medicine at the University of Washington (UW), Program Director of the UW Infectious Diseases Fellowship Program, and Associate Editor of the National STD Curriculum.  

Hit Play Not Pause
BONUS: Another Mother Runner - Menopause + Active Women with Selene Yeager

Hit Play Not Pause

Play Episode Listen Later Apr 10, 2026 50:06


Feisty Media is proud to welcome Another Mother Runner to the Feisty Media family. Enjoy this bonus crossover AMR episode starring, Selene Yeager!--Calling all 40+ women: This is a must-listen episode! The guest is Selene Yeager, host of the popular menopause-focused podcast called Hit Play Not Pause. Selene is the longtime health and science journalist who co-authored ROAR and Next Level with Dr. Stacy Sims. Along with hosts Sarah Bowen Shea and Tish Hamilton, Selene discusses:why a long run can exacerbate night sweats;the in's and out's of hormone therapy;dietary ways to possibly mitigate menopausal symptoms;realistic, actionable ways to strength train; and,how to keep running through midlife.Selene joins the show around 8:25, after Tish talks about her recent “super-secret marathon” and Sarah shares that a 26.2 isn't going to be part of her 2026. (Psst: This episode kicks off a month of Feisty crossover episodes.)

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CCO Infectious Disease Podcast
You're in the Know Podcast: Applying the Latest Advances in Complicated UTI to Practice

CCO Infectious Disease Podcast

Play Episode Listen Later Apr 10, 2026 28:28


In this episode, featuring audio from a local live workshop, experts Richard Colgan, MD, and Christopher Smith, MD, explore the burden of complicated urinary tract infection (cUTI) on patients and the healthcare system, highlight advances in the treatment of complicated UTIs, and examine approaches to empiric and definitive antibiotic therapy. Topics covered include: The Burden of cUTI and Antimicrobial Resistance Changes in IDSA Guidelines for cUTI Diagnosing cUTI Selection of Empiric and Definitive Therapy Novel Treatments for cUTI Get access to all of our new podcasts by subscribing to the Decera Clinical Education Infectious Disease Podcast on Apple Podcasts, YouTube Music, or Spotify. Presenters:  Richard Colgan, MD Professor Emeritus Department of Family and Community Medicine University of Maryland School of Medicine Baltimore, Maryland Christopher Smith, MD Infectious Disease Physician Chase Brexton Healthcare Clinical Assistant Professor Shock Trauma Center, University of Maryland Medical Center Baltimore, Maryland Link to program page: https://bit.ly/3Q4TgDK Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The EMJ Podcast: Insights For Healthcare Professionals
Modelling the Future of AMR: The Next Frontier in Surveillance

The EMJ Podcast: Insights For Healthcare Professionals

Play Episode Listen Later Apr 9, 2026 7:53


In the final deep dive, Cherry Lim looks ahead to the future of AMR surveillance. She discusses the role of microbiology labs, the value of imperfect datasets, and how integrating genomics, modelling, and cost-effectiveness could transform global health systems over the next two decades. Timestamps 00:00 – Introduction 01:03 – Investing in diagnostics 02:36 – Routine surveillance data 03:53 – Global versus local AMR data 05:08 – Future health systems

The EMJ Podcast: Insights For Healthcare Professionals
Modelling the Future of AMR: From Models to Medicine

The EMJ Podcast: Insights For Healthcare Professionals

Play Episode Listen Later Apr 9, 2026 8:22


In this second deep dive episode, Cherry Lim discusses how complex modelling approaches can translate into practical clinical insights. From counterfactual frameworks to real-world prescribing decisions, she explores how data-driven tools can support clinicians in choosing more effective antibiotic treatments.  Timestamps 00:00 – Introduction 01:03 – Understanding counterfactual frameworks 02:56 – Antibiotic choice and survival 05:08 – Clinical decision dashboards 06:24 – Assumptions in AMR modelling

Veterinary Vertex
Addressing Antimicrobial Resistance in U.S. Poultry: Why Environmental Surveillance Matters

Veterinary Vertex

Play Episode Listen Later Apr 8, 2026 16:21 Transcription Available


Send us Fan MailAntimicrobial resistance (AMR) can feel like an abstract, far-away crisis until you realize how easily it travels through connected systems and how quietly it can persist when we only watch the “end product.” We talk with Dr. Pankaj Gaonkar about antimicrobial resistance in the U.S. poultry industry, starting with a clear definition of AMR and why it is a pressing global health and economic threat. From there, we dig into the uncomfortable reality that resistance can still be detected even as antimicrobial use declines, and why that “disconnect” matters for veterinarians, producers, and anyone who cares about food systems.A big theme is scale and structure. Modern poultry production is often vertically integrated, moving birds through a coordinated chain from breeder farms and hatcheries to broiler grow-out and processing. That efficiency has a downside: if antimicrobial resistant bacteria emerge at one point, they can move through the system. We also unpack how disease pressure in high-density environments can influence therapeutic decisions, and how older antimicrobial exposure can leave behind residues and resistant organisms that continue to shape selection pressure over time.The heart of our conversation is environmental surveillance and the One Health approach. Monitoring litter, soil, water, and air around poultry houses helps reveal where resistance is maintained and how it moves between “inside” and “outside” the farm. Pankaj explains key tools like metagenomics, qPCR, and culture-based methods, along with the real challenges around cost, standardization, and interpreting results in complex microbial communities. We close with practical roles for veterinarians and producers, and what smarter policy could look like to strengthen AMR monitoring without creating unnecessary burden.If you found this valuable, subscribe for more Veterinary Vertex conversations, share the episode with a colleague, and leave a rating and review on Apple Podcasts or wherever you listen.JAVMA article: https://doi.org/10.2460/javma.25.07.0488INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ®  OR AJVR ® ?JAVMA ® : https://avma.org/JAVMAAuthorsAJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® :Facebook: Journal of the American Veterinary Medical Association - JAVMA | FacebookInstagram: JAVMA (@avma_javma) • Instagram photos and videosTwitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | FacebookInstagram: AJVR (@ajvroa) • Instagram photos and videosTwitter: AJVR (@AJVROA) / TwitterJAVMA ®  and AJVR ®  LinkedIn: https://linkedin.com/company/avma-journals

The EMJ Podcast: Insights For Healthcare Professionals
Modelling the Future of AMR: Data and Discovery

The EMJ Podcast: Insights For Healthcare Professionals

Play Episode Listen Later Apr 7, 2026 8:14


In this first deep dive, Lim explores how routine hospital data and bacterial genomics are transforming our understanding of AMR. She explains how combining datasets and transmission models can uncover hidden pathways of resistance and highlights the challenges of working across diverse healthcare settings.

The EMJ Podcast: Insights For Healthcare Professionals
Quickfire: Modelling the Future of AMR

The EMJ Podcast: Insights For Healthcare Professionals

Play Episode Listen Later Apr 7, 2026 7:27


Cherry Lim joins the EMJ Podcast for a rapid-fire discussion on data, modelling, and antimicrobial resistance. From surveillance gaps to the role of AI, she shares insights into how data is shaping the future of AMR research and policy.

Another Mother Runner
Menopause + Active Women with Selene Yeager

Another Mother Runner

Play Episode Listen Later Apr 3, 2026 55:32


Calling all 40+ women: This is a must-listen episode! The guest is Selene Yeager, host of the popular menopause-focused podcast called Hit Play Not Pause. Selene is the longtime health and science journalist who co-authored ROAR and Next Level with Dr. Stacy Sims. Along with hosts Sarah Bowen Shea and Tish Hamilton, Selene discusses:why a long run can exacerbate night sweats;the in's and out's of hormone therapy;dietary ways to possibly mitigate menopausal symptoms;realistic, actionable ways to strength train; and,how to keep running through midlife.Selene joins the show around 8:25, after Tish talks about her recent “super-secret marathon” and Sarah shares that a 26.2 isn't going to be part of her 2026. (Psst: This episode kicks off a month of Feisty crossover episodes.)Get 20% off, plus free shipping, on all IQBAR products by texting AMR to 64-000Use code AMR for up to 35% off first subscription order at livemomentous.comWahoo Kickr Run: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdr The 27th Mile Free Events: Head to https://www.manyhappymiles.com/books for more details and to RSVP.Follow us on Instagram: https://www.instagram.com/themotherrunner/ Feisty Fest: Join us from September 18-20, 2026 - https://feisty.co/events/feisty-fest/

Solo Queue - A World of Warcraft Podcast
Midnight Meanderings - Ep 38

Solo Queue - A World of Warcraft Podcast

Play Episode Listen Later Apr 2, 2026 155:51


Midnight Meanderings - Ep 38 SOLO QUEUE DISCORD now available:  https://discord.gg/nXQVqERcSU Show Notes  Welcome to Episode 38! – 2:13         Time to pin you down and force you to listen to what I think of Midnight so far.  Or maybe just entertain you while you work or commute or mow the lawn or whatever it is you are doing.  Thanks for bringing Solo Queue along!  By the way, the countdown checklist idea on a podcast on the day that the U.S. launched four astronauts towards the Moon is sheer coincidence.  In fact, my intro preview came out to Patreon supporters days ago.  Serendipity, baby!   News – 6:37 SQ Socials news Horde neighborhood – Desolate Collective – finally figured out how to add members beyond those on the original charter; not great for momentum, but the key was, as I suspected, strip down to no add-ons and the invite button on the roster actually functioned properly! The test was Gershom and she is the first new member; reach out in game or out if you want to move your Horde house to the Desolate Collective The SQ Guild Solo Together is strong and growing. You can find it in the Alliance Guild Finder, but it is open to both factions.  We have an Alliance side Guild Neighborhood that is open to members of the guild.  If you want to join, just reach out and we will get you an invite, Horde or Alliance.  It is a bunch of cool people of many different backgrounds hanging out, checking in on each other, all very casual.  New Discord link: https://discord.gg/N86fhRkDem  If you are good people, come check it out.  I am @sweeperdave on Discord and of course, soloqueuewow on everything else out there. GT change/delay – yeah, life finds a way into all of my plans; GT on hold, but will return; also quietly on hold is this year's 64-competitor single-elimination tournament among Warcraft characters will take a year off. Rufus is available, Habitat for Humanity; through May 12; The mini war hammer in the mouth is amazing. Music video/marketing from WoW and the musician Aurora is fantastic S1 – what is open, what is left? A lot of S1 is now open with the arrival of M+ keystones last week and the Darkway delve. For raids, the Voidspire and the Dreamrift both opened on Mythic difficulty.  All other diff of the Dreamrift, the one-boss raid, opened the previous week.  For the Voidspire, LFR wing 2 is available, as is the as-yet-unimproved Story Mode version. Coming this week with the March 31 reset is wing 3 of LFR for VS along with the Normal, Heroic, and Mythic versions of the 3rd raid of Midnight, March on Quel'Danas. This is a 2-boss raid.  The Raid Finder/LFR and SM versions arrive the following week on April 7.  And the final delve, the Parhelion Plaza opens this week as well.  New nemesis for the season is Nullaeus, and Valeera Sanguinar is here to help you through all of the Delves. A Race to World First update? On Solo Queue? 9 bosses from all 3 of the raids, with of course the final 2 bosses taking the stage on Tuesday with the launch of the March on Quel'Danas. As of the time of recording, there are three familiar names that have cleared the first two raids and are awaiting the penultimate boss: Liquid, Echo, and Method.  Six more teams are trying to take down the final boss, identified as the Crown of the Cosmos in the Adventure Guide. Spring sale on Bnet – pets and mounts and packs of stuff, along with certain game services Twitch drop is the Cuddly Void Grrgle; before April 23; watch 4 hours of WoW on Twitch 0.5 preview of what is interesting No release date yet, but an 8 week cycle would be April 28, so there is still plenty of time. The Voidforge will help to upgrade gear. That said, the Nebulous Voidcores that you will need to upgrade gear come from M+ d, raids, Bountiful Delves, and Nightmare level Prey Hunts.  More open-world activities launch with 12.0.5 with Void Assaults comprised of Void Strkes and Void Incursions. Another activity is Ritual Sites, a tiered scenario that can be tackled solo or with a party of up to five players. Add the underwater fishing activity called Abyss Anglers and it seems like there will be a lot of options to freshen up your routine midway through Season 1 of Midnight.   Class Identity Challenge – 27:45 On Azeroth Morning Radio, Jibbs described his connection to the Paladin class to his own life and that got me thinking about why I identify with my favorite class, Druid of course.    Hero's Call Co-Opted – 36:33 And continuing with AMR-adjacent content, I low-key (as my 9th grade students say) stole the Hero's Call Board segment from them for a good reason, to highlight someone awesome in the WoW community.   “What Have You Done Lately?” – 53:56        Honestly, not enough Warcraft, but both Haranir characters have been created bringing the active roster to 69.  My oldest active character, and possibly my first character, is the first Horde character to start an expansion for me, and he has hit 90 and already wiped once in the “Story” Mode raid.  Oof.   Main Topic:  My Midnight Experience – 1:29:19 Walking through the leveling campaign going through my thoughts on the zones, storylines, music, graphics, and selected systems in Midnight. Silvermoon City – 1:39:22 Eversong Woods – 1:45:20 Arator's Journey – 1:55:22 Zul'Aman – 1:59:48 Harandar – 2:07:41 Voidstorm – 2:17:40   Closing Thoughts – 2:25:26 Wrapping it all up, including my brief thoughts on the so-called “Story” Mode raid for the Voidspire and a potential reveal of the final boss…   Outro – 2:37:10 Thanks to all of you for your patience in waiting for this episode, Blizzard for the amazing music and sound, to OGRE for intro/outro music, my lovely and supportive wife, my family, and YOU for listening. Support the show at https://www.patreon.com/soloqueuewow Thank you to contributing patrons Andrew, Righteous Bandy, ThatSkyGuy, Cyn, Snek of Voldun, Jon, Scott, Jeru, Raven, Greybeard, Case, Pasta Matt, Luch, and Rak!  And thanks to free members Max, Eddie, Bear, Friends of Wumpus, Sean, Curro, Aronaar, AedinNahkriin, Guardian Sandy, Alice, Don, Kamil, Wednesday, Eric, and TJ! Subscribe to the podcast at your podcast feed of choice, Apple, Spotify, and all the rest.  Leave a 5-star rating and a written review to help grow Solo Queue. You can contact me at soloqueuewow at gmail.com, Bluesky, Twitter, Facebook, Instagram, and Threads. Race to World First is…still a thing.  Go team. “I will see you out there."

Another Mother Runner
Miles of Books: The Way of Excellence with Coach Liz Waterstraat

Another Mother Runner

Play Episode Listen Later Mar 31, 2026 23:46


This week, Sarah Bowen Shea is joined by Coach Liz Waterstraat for a conversation about one nonfiction title: The Way of Excellence by Brad Stulberg. The two talk about how excellence feels more like ease than strain, why values matter, and how curiosity, discipline, and reflection can help athletes, leaders, parents, and anyone else move toward growth.Liz also shares why this personal-development book stands out from the pack—and why it's worth the read.The Way of Excellence by Brad StulbergIQBAR - Get 20% off, plus free shipping, on all IQBAR products by texting AMR to 64000Momentous: Use code AMR for up to 35% off your first subscription order at https://www.livemomentous.com/Follow us on Instagram: https://www.instagram.com/themotherrunner/ Feisty Fest: Join us from September 18-20, 2026 - https://feisty.co/events/feisty-fest/

The New Warehouse Podcast
Modular Warehouse Solutions That Adapt to Change

The New Warehouse Podcast

Play Episode Listen Later Mar 30, 2026 37:59


In this episode of The New Warehouse Podcast, Kevin chats with Ben Hull, Director of Sales at Item America, about how modular warehouse solutions are reshaping operations. Item America, a German-based company with a growing U.S. presence, specializes in aluminum extrusion systems that allow teams to design and build custom solutions on the shop floor. From ergonomic workstations to AMR-compatible carts, the conversation explores how flexibility, customization, and continuous improvement are driving smarter warehouse design. Hull shares how modular thinking helps operations reduce waste, adapt faster, and create solutions that truly fit their needs.Learn more about sponsors here: EPG, iAutomate, Big Joe Forklifts, Surgere, Ocado Intelligent Automation Follow us on LinkedIn and YouTube.Support the show

Thilo Mischke - Uncovered Podcast
Wie schreibt man einen Bestseller? (m. Takis Würger)

Thilo Mischke - Uncovered Podcast

Play Episode Listen Later Mar 30, 2026 59:54 Transcription Available


In der heutigen Folge spricht Thilo mit dem Autor Takis Würger - und zwar als Zusatz zum Buchclub in dem Thilo, Coco und Luca über sein Buch „Für Polina“ gesprochen haben. Takis Würger erzählt im Gespräch nicht nur von seinem aktuellen Roman, sondern auch von seinem Weg zum Schreiben, seinen Erfahrungen als Journalist, seiner Zeit beim Spiegel und davon, wie sehr ihn Beobachtung, Zuhören und präzises Erzählen geprägt haben. Im Gespräch geht es außerdem um die Frage, wie ein Roman entsteht, was für ihn gute Literatur ausmacht und warum Zweifel für ihn ein wichtiger Teil des Schreibens ist. Takis Würger spricht darüber, wie er mit Erfolg, Kritik und Erwartungen umgeht, und was ihn an Figuren, Geschichten und dem Schreiben selbst immer wieder neu reizt. Natürlich kommt auch sein Buch „Für Polina“ zur Sprache: über den Ton des Romans, die Figuren, die Liebesgeschichte und darüber, warum das Buch für viele Leserinnen und Leser so besonders berührend ist. Hast du Fragen, Feedback oder Anmerkungen? Schreib uns eine Nachricht an [amr@pqpp2.de](mailto:amr@pqpp2.de) oder auf Instagram: https://www.instagram.com/allesmussraus_podcast/ und wenn du möchtest unterstütze unsere Arbeit auf Patreon: https://www.patreon.com/c/AllesMussRaus?l=de Du möchtest in „Alles Muss Raus“ werben? Dann hier* entlang: https://podstars.de/kontakt/?utm_source=podcast&utm_campaign=shownotes_alles-muss-raus

Another Mother Runner
Jumpstart Your Running! with Jen Harrison and Erin Haugen, Ph.D

Another Mother Runner

Play Episode Listen Later Mar 27, 2026 57:55


Anyone looking to kickstart her running habit—or begin a new one—will appreciate this episode featuring Jennifer Harrison, a veteran endurance coach and accomplished triathlete, and sport psychologist Erin Haugen, Ph.D. Along with the hosting duo of Sarah Bowen Shea and Amanda Loudin, they discuss:how adding walks into your run can re-ignite joythe natural ebb and flow of exercisinggetting over the fear of re-injuryways to shed the dread of a runthat your “why” doesn't need to be a deep, meaningful thingBefore Coach Jen joins around 8:40, the hosts also enjoy a quick catch-up on work (Amanda) and family (Sarah).Momentous: Use code AMR for up to 35% off your first subscription order at https://www.livemomentous.com/IQBAR - Get 20% off, plus free shipping, on all IQBAR products by texting AMR to 64000Follow us on Instagram: https://www.instagram.com/themotherrunner/ Feisty Fest: Join us from September 18-20, 2026 - https://feisty.co/events/feisty-fest/

Thilo Mischke - Uncovered Podcast
#amr_buchklub zu "Für Polina": ein Liebesroman, modernes Märchen oder die philosophische Suche nach dem Sinn des Lebens?

Thilo Mischke - Uncovered Podcast

Play Episode Listen Later Mar 27, 2026 72:45 Transcription Available


In der neuen Buchclub-Folge sprechen Thilo, Coco und Luca über „Für Polina“ von Takis Würger – einen Roman, der für Coco zur „10 von 10“ und zu einem ihrer Lebens-Lieblingsbücher geworden ist, während Luca eher zwischen Bewunderung und Skepsis schwankt. Thilo liest „Für Polina“ dabei als bewusst märchenhafte, eskapistische Liebesgeschichte, die mit viel Kitsch arbeitet – aber gerade dadurch funktioniert das Buch für ihn als tröstendes, warmes Wohlfühlbuch.​ Die drei tauchen mit dem Protagonisten Hannes, dem hochbegabten, stillen Musiker, ein in eine märchenhaft überhöhte Welt aus Moorvilla, Klavierträger-Alltag und großen Gefühlen und diskutieren, ob das Buch eher Liebesroman, modernes Märchen oder philosophische Suche nach dem Sinn des Lebens ist. Dabei geht es um Szenen, die mitten ins Herz treffen, um die Frage, ob Kitsch erlaubt – oder sogar nötig – ist, damit Literatur tröstet, und um den Satz „Liebe ist Hoffnung“, der zum zentralen Moment des Buches wird. Dieses Buch solltest du lesen, wenn du in eine satte, tröstliche Welt eintauchen willst, Figuren liebst, die dich halten wie eine warme Decke, und erleben möchtest, wie leichtfüßig Sprache große Gefühle und Bilder erzeugt, ohne dass du dafür „Literaturprofi“ sein musst. Hast du Fragen, Feedback oder Anmerkungen? Schreib uns eine Nachricht an [amr@pqpp2.de](mailto:amr@pqpp2.de) oder auf Instagram: https://www.instagram.com/allesmussraus_podcast/ und wenn du möchtest unterstütze unsere Arbeit auf Patreon: https://www.patreon.com/c/AllesMussRaus?l=de Du möchtest in „Alles Muss Raus“ werben? Dann hier* entlang: https://podstars.de/kontakt/?utm_source=podcast&utm_campaign=shownotes_alles-muss-raus

Another Mother Runner
Miles of Books: Four Novels Written by Women

Another Mother Runner

Play Episode Listen Later Mar 24, 2026 25:21


Your favorite book-recommendation podcast is back! Hosts Sarah Bowen Shea and Ellison Weist kick things off by talking about four novels from women writers, including a buzzy one Sarah enjoyed listening to on her runs.The Elopement: Gill HornbyKin: Tayari JonesGood People: Patmeena SabitMurder Bimbo: Rebecca NovackSupport our partners:Feisty + AMR appreciate your—and their—support!Get 20% off, plus free shipping, on all IQBAR products by texting AMR to 64-000Use code AMR for up to 35% off first subscription order at livemomentous.com

The Low Carb Athlete Podcast
Part One AMPK Dominance & PNOĒ Metabolism Clues — Are You Stuck in Burn Mode?

The Low Carb Athlete Podcast

Play Episode Listen Later Mar 23, 2026 59:59


Are you great at burning fat—but struggling with recovery, muscle, energy, or stubborn body composition? In this Part 1 episode, Coach Debbie Potts takes you down a deep-dive rabbit hole into AMPK dominance, the "burn mode" many high performers and endurance athletes unknowingly live in. You'll learn how chronic stress, under-fueling, fasting, and excessive endurance training can shift your body into energy conservation instead of rebuilding—and why this becomes even more important in midlife. Debbie breaks down the difference between being a fat burner vs. metabolically flexible, and how PNOĒ metabolism testing reveals key clues at rest (RMR) and during exercise (AMR), including: • Low resting metabolic rate (RMR) and what it really means • Fat-burning dominance vs true metabolic flexibility • Poor high-intensity capacity and "flat" performance • Limited carbohydrate access when you need it most • Signs of chronic AMPK activation and reduced mTOR signaling This episode will help you understand why your body may feel stuck—even when you're doing everything "right"—and why the solution isn't more discipline, but better metabolic signaling and strategy. This is where you stop guessing… and start connecting the clues.

Podcast – F1Weekly.com – Home of The Premiere Motorsport Podcast (Formula One, GP2, GP3, Motorsport Mondial)

ON TODAYS PROGRAM…   MAX ON POLE TAKES VICTORY AT THE NURBURGRING AND IS DISQUALIFIED! HOURS LATER. THE WORLD KNOWS MERCEDES IS HOLDING BACK POWER! ASTON MARTIN'S WORKING ENVIRONMENT BECOMING UNCOMFORTABLE AS ADRIAN NEWEY IS REMOVED AS TEAM PRINCIPAL LEAVING ROOM FOR JONATHAN WHEATLEY TO TAKE OVER AND…THE MOST OBVIOUS QUESTION IS …WHEN WILL ANTONELLI REPLACE LEWIS AT FERRARI? THIS WEEK'S NASIR HAMEED CORNER WE HAVE: KAZUKI NAKAJIMA,  ASTON MARTIN ARAMCO FORMULA ONE™ TEAM STATEMENT FROM LAWRENCE STROLL. “With the current speculation surrounding Adrian Newey's role in our team, I want to take this opportunity to set the record straight. “As Executive Chairman and Controlling Shareholder, I would like to reaffirm that Adrian Newey is my partner and an important shareholder. He is AMR's Managing Technical Partner, and he and I have a true partnership built on a shared vision of success for the company. “We do things differently here, and while we don't currently adopt the traditional Team Principal role that you see elsewhere - it is by design. “As the most successful engineer ​in the history of the sport, Adrian's primary focus is on the strategic and technical leadership where he excels. He is supported by a highly skilled Senior Leadership Team to deliver on all aspects of the business, both at the Campus and trackside. “We are regularly approached by senior executives of other teams who wish to join Aston Martin Aramco, but in keeping with our policy, we do not comment on rumour and speculation.” New management structure for the Audi F1 Project. Jonathan Wheatley is leaving Audi Revolut F1 Team effective immediately for personal reasons Mattia Binotto assumes responsibilities as Team Principal in addition to his role as Head of Audi F1 Project   Audi CEO Gernot Döllner: “We will continue to pursue the path we have chosen with determination”   Audi has made an adjustment to the management structure of its Formula 1 project. In addition to his existing duties as Head of Audi F1 Project, Mattia Binotto will also assume the responsibilities of Team Principal. Jonathan Wheatley is leaving the Audi Revolut F1 Team with immediate effect for personal reasons. Wheatley had been part of the Audi F1 Project since April 2025. Together with Binotto, he built up the racing team at the Hinwil facility in Switzerland, which immediately scored points on its Formula 1 debut in early March. With this transition, Mattia Binotto will now assume additionally the responsibilities of Team Principal, taking leadership at the race track of Audi Revolut F1 Team. “We are grateful to Jonathan Wheatley for his contribution to the project during the crucial entry phase and wish him all the best for the future,” says Gernot Döllner, CEO of AUDI AG and Chairman of the Board of Management of Audi Motorsport AG. “Mattia Binotto and the team will continue to pursue the path we have chosen with determination. Our focus remains unchanged: we are concentrating all our efforts on building a team competing at the highest level that will challenge for world championships in Formula 1 by 2030. We will continuously develop our organizational structures to achieve our shared goal in a sustainable manner.”   Penske Entertainment Statement on Passing of Jim Michaelian   INDIANAPOLIS (Saturday, March 21, 2026) – A statement from Roger Penske about the passing March 21 of Grand Prix Association of Long Beach President and CEO Jim Michaelian: “Everyone at Penske Entertainment and within the INDYCAR community is deeply saddened by the passing of Jim Michaelian. Jim was a leader of a small, passionate group who believed in the concept of bringing elite open-wheel competition to Long Beach in the 1970s, worked tirelessly to make it happen despite steep odds and then helped nurture the Grand Prix of Long Beach into becoming America's premier street race. His vision and energy surrounding this great event remained boundless for 50 years, as no task was too small for Jim even while he served in numerous leadership roles. Penske Entertainment is committed to honoring Jim's legacy of putting fans and competitors first as we continue to build on the strong foundation he and his staff created for a half-century in Long Beach. Our deepest sympathies are with his wife, Mary, and their sons, Bob and Mike.”

Another Mother Runner
The Return of Our Podcasts + the Power of Community

Another Mother Runner

Play Episode Listen Later Mar 20, 2026 50:30


Yes, we're BACK!Thanks to a merger with Feisty Media, this episode kicks off the return of Another Mother Runner (both the podcasts and the company!). In this live relaunch episode, hosts Sarah Bowen Shea and Britany Williams are joined by AMR co-founder Dimity McDowell and Sara Gross, founder and CEO of Feisty.Recorded in front of a lively audience at the Portland Running Company, the quartet discusses the myriad ways community matters, especially for active women—and they pull back the curtain on how these two women-centric, sporty brands joined forces.This show is a production of Another Mother Runner and Feisty Media. Learn more about Feisty—their community, other shows, workshops, and events, including FeistyFest.Episode resources:Feisty: feisty.coFeistyFest: feisty.co/events/feisty-fest/

ceo community podcasts feisty amr another mother runner sara gross sarah bowen shea feisty media dimity mcdowell
Thilo Mischke - Uncovered Podcast
Was passiert gerade in Kuba? (m. Edgar Göll)

Thilo Mischke - Uncovered Podcast

Play Episode Listen Later Mar 19, 2026 47:39 Transcription Available


In dieser Folge spricht Thilo mit Edgar Göll – er ist Soziologe, Zukunftsforscher und Kuba-Experte. Seit über 30 Jahren beschäftigt er sich intensiv mit dem Land, forscht zu seinen gesellschaftlichen Entwicklungen und war zuletzt selbst vor Ort. Anlass des Gesprächs ist die aktuelle politische Lage: Die USA unter Donald Trump verschärfen erneut die Sanktionen gegen Kuba. Besonders die Einschränkung von Öl-Lieferungen bringt das Land zunehmend in eine akute Versorgungskrise. Die Folgen sind im Alltag der Menschen deutlich spürbar – leere Regale, Stromausfälle, fehlendes Benzin und Engpässe im Gesundheitswesen. Doch während sich die Situation zuspitzt, richtet sich der Blick auch auf eine andere Seite Kubas. Trotz jahrzehntelanger Sanktionen zeigt das Land eine bemerkenswerte Widerstandsfähigkeit. In Bereichen wie Bildung, Gesundheitsversorgung und Nachhaltigkeit nimmt Kuba international eine besondere Rolle ein und engagiert sich gleichzeitig weltweit durch medizinische Hilfseinsätze. Gemeinsam gehen Thilo und Edgar der Frage nach, was Sanktionen tatsächlich bewirken – und wer am Ende den Preis dafür zahlt. Sie sprechen über geopolitische Spannungen, die Rolle von Exil-Kubanern und internationalen Akteuren sowie darüber, warum ein militärischer Konflikt als unwahrscheinlich gilt. Gleichzeitig wird deutlich, wie sehr sich die Lebensrealität der Menschen auf der Insel verschärft – und warum diese Entwicklung international oft wenig Beachtung findet. Hast du Fragen, Feedback oder Anmerkungen? Schreib uns eine Nachricht an [amr@pqpp2.de](mailto:amr@pqpp2.de) oder auf Instagram: https://www.instagram.com/allesmussraus_podcast/ und wenn du möchtest unterstütze unsere Arbeit auf Patreon: https://www.patreon.com/c/AllesMussRaus?l=de Du möchtest in „Alles Muss Raus“ werben? Dann hier* entlang: https://podstars.de/kontakt/?utm_source=podcast&utm_campaign=shownotes_alles-muss-raus

One World, One Health
Beyond the Frontlines – Tackling Drug Resistance in Conflict Zones

One World, One Health

Play Episode Listen Later Mar 10, 2026 19:28


Send a textImagine this scene:A family's house was destroyed when it was bombed during a war. They got out with the clothes on their backs – nothing more. When they were fleeing, the mother was hit with fragments from another bomb. It tore off part of her leg. Dirt got in the wound.They made it to a refugee camp, but the wound got infected. With nothing available to treat the injury, the infection got worse. She had a drug-resistant infection that wasn't treatable with regular antibiotics. Her entire leg and part of her hip had to be removed to save her life. She will have a physical disability for the rest of her life.This is just one story of drug resistance or antimicrobial resistance (AMR)  and the impact of armed conflict. Report after report finds that victims of armed conflict and refugees – both those seeking shelter abroad and inside their own countries – are especially likely to suffer from drug-resistant infections.Dr. Aula Abbara, Consultant in Infectious Diseases and Acute Medicine and Honorary Senior Clinical Lecturer at Imperial College, London, has been studying the problem firsthand.She's worked with teams that found people injured in Syria's 15-year-long conflict not only suffered terrible wounds, but then developed worse infections because of crowded and unsanitary conditions in healthcare facilities. These war-damaged hospital laboratories in Syria, especially, lacked the capacity to test for drug-resistant bacteria, and so doctors didn't know which antibiotics to prescribe to treat patients' infections.Solutions require taking a One Health approach, Dr. Abbara and colleagues have found.She and her colleagues call for programs to bring in more health professionals and healthcare access; introduction of easy-to-use diagnostics so people's infections can be immediately diagnosed and thus treated with the correct drugs; stopping the improper use and distribution of antibiotics; and proper surveillance so that professionals know which drug-resistant infections are spreading and where.In this episode of One World, One Health, Dr. Abbara chats with host Maggie Fox about what she's seen and what might help.

Clark County Today News
Early-Morning Apartment Deck Fire in Vancouver Sends One to Hospital

Clark County Today News

Play Episode Listen Later Mar 10, 2026 0:45


A fire broke out on a second-story apartment deck shortly after 4:30 a.m. on March 10, drawing a response from the Vancouver Fire Department and prompting residents to evacuate the building. Firefighters extinguished the balcony blaze and searched nearby apartments to make sure flames had not spread, while AMR crews evaluated and transported one adult with respiratory distress. The Vancouver Fire Marshal's Office is now investigating the cause of the Vancouver apartment fire. Read the full story at https://www.clarkcountytoday.com/news/balcony-fire-in-vancouver-extinguished/ #VancouverWA #VancouverFireDepartment #ClarkCountyWA #ApartmentFire #FireResponse #LocalNews

Communicable
Communicable E48: International Women's Day - are infections & AMR really different in women?

Communicable

Play Episode Listen Later Mar 8, 2026 39:24


Yesterday was International Women's Day. In light of that, Communicable prepared a special episode in which hosts Erin McCreary and Annie Joseph are joined by Esmita Charani (South Africa) and Annette Westgeest (Netherlands) for a discussion on gender- and sex-dependent patient-care disparities in the infectious diseases space. Together they review recent research findings that identified gender and sex as important determinants influencing patient outcomes and even decision making by prescribers. They also explore how societal and cultural norms may introduce further nuance and complexities. The panel remains optimistic in reaching equal healthcare for all, reflecting also on progressive steps such as increasing recognition by international organisations like the WHO, which published guidance on gender inequalities in national plans on AMR in 2024.This episode was peer reviewed by Casandra Bulescu at the Dr. Victor Babes Clinical Hospital of Infectious and Tropical Diseases in Bucharest, Romania.ReferencesCharani E, et al. Wellcome Open Research, 2024. Charani E, et al. Lancet Global Health, 2023.WHO guidance on gender inequalities in national action plans on AMR, 2024.Westgeest AC's presentation at ESCMID Global 2023.Dellière S, et al. Clin Microbiol Infect, 2026.Westgeest AC, et al. Clin Microbiol Infect, 2023.Madsen TE, et al. DISPARITY-II study, 2014.Criado Perez, C. Invisible Women. Ausman SE, et al. CLASI study, 2023.Vaughn VM, et al. ICHE, 2022.Szymczak JE. Clin Infect Dis, 2019.

The EMJ Podcast: Insights For Healthcare Professionals
Fighting AMR for Child Health: Lessons from HIV and Vaccines

The EMJ Podcast: Insights For Healthcare Professionals

Play Episode Listen Later Mar 5, 2026 8:55


Drawing on her landmark work in HIV and vaccine research, Glenda Gray shares powerful lessons for tackling AMR in this last deep dive episode. From prevention and behavioural science to protecting high-risk populations, she explains how strategies that transformed HIV outcomes can inform a more effective and equitable AMR response. Timestamps: 00:00 – Introduction 01:02 – Lessons from HIV 02:47 – Vaccine trials 03:50 – AMR interventions 05:17 – Behavioural science 06:31 – Key takeaways

eCom Logistics Podcast
Meeting the AI-Empowered Consumer: Logistics Strategy in a Comparison-Driven Economy

eCom Logistics Podcast

Play Episode Listen Later Mar 4, 2026 30:13


WHAT YOU'LL LEARN Why retail is now a demand chain, not a supply chain How AMRs deliver 6–12 month ROI in high-variability e-commerce Why robotics-as-a-service changes peak capacity planning The real bottleneck in AI adoption: structured WMS data Why dashboards are dying and exception-based orchestration is rising How consolidation will reshape 3PL economics Why operational excellence remains the ultimate differentiator HIGHLIGHTS 00:01–00:12 | Consumer expectations and the “fast + free + cheap” reality 00:12–00:15 | AMRs, ASRS, RaaS, and 6–12 month automation ROI 00:15–00:16 | Buy vs build: what's commodity vs “secret sauce” 00:16–00:19 | Agentic AI in warehouse ops: labor planning + execution 00:19–00:22 | AI proof, case studies, and demand planning as the next frontier 00:22–00:24 | Dashboards vs operators: turning analytics into actions 00:24–00:28 | Operator advice: efficiency, mechanization, and competition shifts 00:29–00:31 | Manifest trends: retail channels evolving + tech-driven 3PL future QUOTES  [00:04:10] “One of the biggest changes is you used to have a choice. You could either have it fast, you could have it free, or you could have it cheap. The consumer today wants all three.” – Jeff Wolpov [00:05:10] “We as logistics supply chain companies need to lean in and figure out how to do more with less. Today it's a necessity.” – Jeff Wolpov [00:07:30] “You need automation... We need to be faster and more flexible. Peaks have gotten much higher.” – Jeff Wolpov [00:16:00] "The hard part isn't building AI or using AI. It's what do you do with the results?" - Gary Allen [00:16:50] “Operators shouldn't hunt dashboards, they should get alerts, exception-based triggers. AI takes analytics to the next level.” – Gary Allen [00:23:00] "Reporting is the death of analytics." - Gary Allen  ABOUT THE GUESTS Jeff Wolpov Jeff Wolpov is Senior Vice President of E-commerce and Ryder Last Mile at Ryder System, Inc., where he leads the vision and strategy for omnichannel fulfillment and big & bulky home delivery. Previously, he served as CEO of Whiplash (formerly Port Logistics Group), achieving nearly 30% year-over-year revenue growth before its acquisition by Ryder in 2022. Earlier in his career, Jeff founded Distribution Solutions, scaling it from a startup into a $50 million regional logistics firm that became the foundation of Whiplash's national network. He holds a degree from the University of Michigan. Gary Allen Gary Allen is Vice President of Supply Chain Excellence at Ryder, overseeing Solution Design, Continuous Improvement, Data Analytics, and Automation across the supply chain organization. With more than 32 years of experience, he previously led EY's logistics consulting practice and held leadership roles at DHL and FedEx in product innovation, solution design, sustainability, and operations. Gary helped launch and co-author the “Annual Third Party Logistics Study” with Dr. John Langley of Penn State University and holds a Bachelor of Arts in Materials and Logistics Management from Michigan State University. LINKS MENTIONED Ryder report: https://www.ryder.com/en-us/insights/white-papers/e-comm/2025-ryder-e-commerce-consumer-study Ryder website: https://www.ryder.com/en-us Subscribe and Keep Learning!If you're a logistics leader looking to scale sustainably, don't miss out! Subscribe for more expert strategies on tackling modern supply chain challenges.Be sure to follow and tag the eCom Logistics Podcast on LinkedIn and YouTube

The EMJ Podcast: Insights For Healthcare Professionals
Quickfire: Fighting AMR for Child Health

The EMJ Podcast: Insights For Healthcare Professionals

Play Episode Listen Later Mar 2, 2026 6:07


Glenda Gray joins the EMJ Podcast for a quickfire discussion on antimicrobial resistance and child health. From antibiotic misconceptions to equitable access and stewardship, she shares sharp insights into why AMR is a defining global health challenge for children today.

The EMJ Podcast: Insights For Healthcare Professionals
Fighting AMR for Child Health: The Science and Scale of Resistance

The EMJ Podcast: Insights For Healthcare Professionals

Play Episode Listen Later Mar 2, 2026 7:27


In this first deep dive, Glenda Gray unpacks what antimicrobial resistance means for clinicians beyond infectious diseases, and why it is already a leading cause of death globally. She explores the disproportionate burden in low- and middle-income countries, the devastating impact on neonates and infants, and the critical role of diagnostics, vaccines, and infection prevention. Timestamps: 00:00 – Introduction 00:45 – What is AMR? 01:32 – Burden on LMICs  02:57 – Impact on infants 04:05 – Diagnostic gaps 05:10 – Comprehensive strategies

3 Things
An expert on what makes AMR a silent pandemic

3 Things

Play Episode Listen Later Feb 20, 2026 31:02 Transcription Available


Antimicrobial resistance, or AMR, is often described as a silent pandemic. With antibiotics losing their effectiveness due to overuse and misuse, we look at how serious India's AMR burden is and why drug-resistant infections are rising. The Indian Express' Rinku Ghosh and Shashank Bhargava speak with Dr Kamini Walia of the Indian Council of Medical Research about what is driving this crisis and what can be done to slow it.Hosted by Ichha SharmaProduced and written by Shashank Bhargava and Ichha SharmaEdited and mixed by Suresh Pawar

Plant Based Briefing
1225: Sales of Antibiotics for Farm Animals Jumped 16%, FDA Data Shows by Natasha Gilbert at SentientMedia.org

Plant Based Briefing

Play Episode Listen Later Feb 17, 2026 8:04


Sales of Antibiotics for Farm Animals Jumped 16%, FDA Data Shows The sharp one-year increase is raising concerns among public health experts.Listen to today's episode written by Natasha Gilbert at sentientmedia.org. **And check out the free documentary on antibiotic or antimicrobial resistance, THE END OF MEDICINE AS WE KNOW IT: https://www.youtube.com/watch?v=XAYHTr7NDdQ  #vegan #plantbased #plantbasedbriefing #antibioticresistance, #AMR #antimicrobialresistance  ========================== Original Post: https://sentientmedia.org/sales-of-antibiotics-for-farm-animals-jumped/  ========================= Related Episodes: SEARCH: Use search feature at https://www.plantbasedbriefing.com/episodes-search     Documentary: The End of Medicine as We Know It https://www.youtube.com/watch?v=XAYHTr7NDdQ  881: Alternative Proteins' Place On The Global Health Agenda https://plantbasedbriefing.libsyn.com/881-alternative-proteins-place-on-the-global-health-agenda-by-chelsea-montes-de-oca-at-gfiorg  637: [Part 2] Zoonotic Disease And Animal Welfare In The U.S. https://plantbasedbriefing.libsyn.com/637-part-2-zoonotic-disease-and-animal-welfare-in-the-us-by-kristen-a-stilt-bonnie-nadzam-at-faunalyticsorg  616: There's Nothing Natural About Modern Meat https://plantbasedbriefing.libsyn.com/616-theres-nothing-natural-about-modern-meat-by-jessica-scott-reid-at-sentientmediaorg 360: Antibiotic Resistance Genes in the Guts of Vegetarians vs. Meat-Eaters https://plantbasedbriefing.libsyn.com/360-antibiotic-resistance-genes-in-the-guts-of-vegetarians-vs-meat-eaters-by-dr-michael-greger-at-nutritionfactsorg 333: [Part 2] Antimicrobial Resistance (AMR) - Increasing the Impact of Pandemics https://plantbasedbriefing.libsyn.com/333-part-2-antimicrobial-resistance-amr-increasing-the-impact-of-pandemics-by-proveg-international-at-provegcom 332: [Part 1] Antimicrobial Resistance (AMR) - Increasing the Risk of Pandemics https://plantbasedbriefing.libsyn.com/332-antimicrobial-resistance-amr-increasing-the-risk-of-pandemics-by-proveg-international-at-provegcom 326: Eating our way to Extinction – Film Review https://plantbasedbriefing.libsyn.com/205-eating-our-way-to-extinction-film-review-by-bronwyn-slater-at-vegansustainabilitycom ====================== Sentient Media is a nonprofit news organization that is changing the conversation around animal agriculture across the globe. They seek to create and sustain a sense of global urgency about the agriculture industry's impact on the climate crisis, extraction of natural resources and systematic exploitation of the fringes of society. They're doing this through critical commentary, investigative journalism, creating resources, strengthening the journalist and advocate community, partnering with publishers and holding the media accountable when it fails to report on the most pressing issues of our time.  ========================== FOLLOW THE SHOW ON: YouTube: https://www.youtube.com/@plantbasedbriefing     Spotify: https://open.spotify.com/show/2GONW0q2EDJMzqhuwuxdCF?si=2a20c247461d4ad7 Apple Podcasts: https://podcasts.apple.com/us/podcast/plant-based-briefing/id1562925866 Your podcast app of choice: https://pod.link/1562925866 Facebook: https://www.facebook.com/PlantBasedBriefing   LinkedIn: https://www.linkedin.com/company/plant-based-briefing/   Instagram: https://www.instagram.com/plantbasedbriefing/     

Cardionerds
440. Heart Failure: Post-Heart Transplant Management with Dr. Shelly Hall and Dr. MaryJane Farr

Cardionerds

Play Episode Listen Later Feb 4, 2026 26:16


CardioNerds (Dr. Shazli Khan, Dr. Jenna Skowronski, and Dr. Shiva Patlolla) discuss the management of patients post‑heart transplantation with Dr. Shelley Hall from Baylor University Medical Center and Dr. MaryJane Farr from UTSW. In this comprehensive review, we cover the physiology of the transplanted heart, immunosuppression strategies, rejection surveillance, and long-term complications including cardiac allograft vasculopathy (CAV) and malignancy. Audio editing for this episode was performed by CardioNerds intern Dr. Bhavya Shah. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Heart Success Series PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls The Denervated Heart: The donor heart is surgically severed from the autonomic nervous system, leading to a higher resting heart rate (90-110 bpm) due to loss of vagal tone. Because the heart relies on circulating catecholamines rather than neural input to increase heart rate, patients experience a delayed chronotropic response to exercise and stress. Importantly, because afferent pain fibers are severed, ischemia is often painless. Rejection Surveillance: Rejection is classified into Acute Cellular Rejection (ACR), which is T-cell mediated, and Antibody-Mediated Rejection (AMR), which is B-cell mediated. While endomyocardial biopsy remains the gold standard for diagnosis, non-invasive surveillance using gene-expression profiling (e.g., AlloMap) and donor-derived cell-free DNA (dd-cfDNA) is increasingly utilized to reduce the burden of invasive procedures. The Infection Timeline: The risk of infection follows a predictable timeline based on the intensity of immunosuppression. The first month is dominated by nosocomial infections. Months one through six are the peak for opportunistic infections (Cytomegalovirus, Pneumocystis, Toxoplasmosis) requiring prophylaxis. After six months, patients are primarily at risk for community-acquired pathogens, though late viral reactivation can occur. Cardiac Allograft Vasculopathy (CAV): Unlike native coronary artery disease, CAV presents as diffuse, concentric intimal thickening that affects the entire length of the vessel, including the microvasculature. Due to denervation, patients rarely present with angina; instead, CAV manifests as unexplained heart failure, fatigue, or sudden cardiac death. Malignancy Risk: Long-term immunosuppression significantly increases the risk of malignancy. Skin cancers (squamous and basal cell) are the most common, followed by Post-Transplant Lymphoproliferative Disorder (PTLD), which is often driven by Epstein-Barr Virus (EBV) reactivation. Notes Notes: Notes drafted by Dr. Patlolla 1. What are the unique physiological features of the transplanted heart? The hallmark of the transplanted heart is denervation. Because the autonomic nerve fibers are severed during harvest, the heart loses parasympathetic or vagal tone, resulting in a resting tachycardia (typically 90-110 bpm). The heart also loses the ability to mount a reflex tachycardia; thus, the heart rate response to exercise or hypovolemia relies on circulating catecholamines, which results in a slower “warm-up” and “cool-down” period during exertion. 2. What are the pillars of maintenance immunosuppression regimen? The triple drug maintenance regimen typically consists of: Calcineurin Inhibitor (CNI): Tacrolimus is preferred over cyclosporine. Key side effects include nephrotoxicity, hypertension, tremor, hyperkalemia, and hypomagnesemia. Antimetabolite: Mycophenolate mofetil (MMF) inhibits lymphocyte proliferation. Key side effects include leukopenia and GI distress. Corticosteroids: Prednisone is used for maintenance but is often weaned to low doses or discontinued after the first year to mitigate metabolic side effects (diabetes, osteoporosis, weight gain). 3. How is rejection classified and diagnosed? Rejection is the immune system’s response to the foreign graft and is categorized by the arm of the immune system involved: Acute Cellular Rejection (ACR): Mediated by T-lymphocytes infiltrating the myocardium. It is graded from 1R (mild) to 3R (severe) based on the extent of infiltration and myocyte damage. Antibody-Mediated Rejection (AMR): Mediated by B-cells producing donor-specific antibodies (DSAs) that attack the graft endothelium. It is diagnosed via histology (capillary swelling) and immunofluorescence (C4d staining). Diagnosis has historically relied on endomyocardial biopsy. However, non-invasive tools are gaining traction. Gene Expression Profiling (GEP) assesses the expression of genes associated with immune activation to rule out rejection in low-risk patients. Donor-Derived Cell-Free DNA (dd-cfDNA) measures the fraction of donor DNA in the recipient’s blood. Elevated levels suggest graft injury which can occur in both ACR and AMR. 4. What is the timeline of infectious risk and how does it guide prophylaxis? Infectious risk correlates with the net state of immunosuppression. < 1 Month (Nosocomial): Risks include surgical site infections, catheter-associated infections, and aspiration pneumonia. 1 – 6 Months (Opportunistic): This is the period of peak immunosuppression. Patients are at risk for PJP, CMV, Toxoplasma, and fungal infections. Prophylaxis typically includes Trimethoprim-Sulfamethoxazole (for PJP/Toxo) and Valganciclovir (for CMV, dependent on donor/recipient serostatus). > 6 Months (Community-Acquired): As immunosuppression is weaned, the risk profile shifts toward community-acquired respiratory viruses (Influenza, RSV) and pneumonias. However, patients with recurrent rejection requiring boosted immunosuppression remain at risk for opportunistic pathogens. 5. How does Cardiac Allograft Vasculopathy (CAV) differ from native CAD? CAV is the leading cause of late graft failure. Unlike the focal, eccentric plaques seen in native atherosclerosis, CAV is an immunologically driven process causing diffuse, concentric intimal hyperplasia. It affects both epicardial vessels and the microvasculature. Because of this diffuse nature, percutaneous coronary intervention (PCI) is often technically difficult and provides only temporary palliation. The only definitive treatment for severe CAV is re-transplantation. Surveillance is critical and is typically performed via annual coronary angiography, often using intravascular ultrasound (IVUS) to detect early intimal thickening before it is visible on the angiogram. References Costanzo MR, Dipchand A, Starling R, et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29(8):914-956. doi:10.1016/j.healun.2010.05.034. https://www.jhltonline.org/article/S1053-2498(10)00358-X/fulltext Kittleson MM, Kobashigawa JA. Cardiac Allograft Vasculopathy: Current Understanding and Treatment. JACC Heart Fail. 2017;5(12):857-868. doi:10.1016/j.jchf.2017.07.003. https://www.jacc.org/doi/10.1016/j.jchf.2017.07.003 Velleca A, Shullo MA, Dhital K, et al. The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2023;42(5):e1-e141. doi:10.1016/j.healun.2022.10.015. https://www.jhltonline.org/article/S1053-2498(22)02187-5/fulltext

Another Mother Runner
2025 End-of-Year Co-Host Conversations, Pt. 2

Another Mother Runner

Play Episode Listen Later Dec 19, 2025 60:38


Three co-hosts sit down and share in this second installment of this annual tradition-episode: Molly Williams, Tish Hamilton, and the OG herself, Dimity McDowell. Along with host Sarah Bowen Shea, each gal shares her 2025 physical pursuits—as well as their plans for 2026. There is also the detailed background of the AMR origin story, plus laughter and tears remembering past episodes (hello, Chris McDougall and his “ass!”) and in-person AMR adventures.    Head here to sign up for notifications about the potential continuation of AMR podcasts.     When you shop our sponsors, you help AMR.We appreciate your—and their—support!   Save 15% thru 1/31/26w/ code AMRwinter25 at topoathletic.com   Use code AMR for up to 35% off first subscription order at livemomentous.com   Get 20% off, plus free shipping, on all IQBAR products by texting AMR to 64-000 Learn more about your ad choices. Visit megaphone.fm/adchoices

conversations end of year amr chris mcdougall molly williams sarah bowen shea dimity mcdowell tish hamilton
Another Mother Runner
Miles of Books: Four Novels + Two "Riveting" True Tales

Another Mother Runner

Play Episode Listen Later Dec 16, 2025 30:23


Anyone looking for books to delve into during the holidays, look (and listen!) no further: Hosts Sarah Bowen Shea and Ellison Weist serve up four compelling new novels—including one they both found exquisitely crafted—plus two non-fiction books they won't soon forget.  The books the hosting duo recommends:Heart of the Lover: Lily KingThe Loneliness of Sonia and Sunny: Kiran DesaiThe Ten Year Affair: Erin SomersFlesh: David SzalayA Marriage at Sea: Sophie ElmhirstEmpire of Pain: Patrick Radden Keefe Head here to sign up for notifications about the future of AMR podcasts.     When you shop our sponsors, you help AMR.We appreciate your—and their—support!   Check out the full Currex lineup +get 15% off with code AMR15 at Currex.com Use code AMR for up to 35% off first subscription order at livemomentous.com Get 20% off, plus free shipping, on all IQBAR products by texting AMR to 64-000 Learn more about your ad choices. Visit megaphone.fm/adchoices