Podcasts about Allergy

For decades, peanut allergies were on the rise in the US. But a study released on October 20 found that peanut allergies in babies and young children are now decreasing. This drop correlates with a change in guidance from the National Institute of Allergy and Infectious Diseases. In 2017, the agency started recommending exposing children to peanuts “early and often.” Since that recommendation, the prevalence of peanut allergies has dropped significantly.Sharon Chinthrajah, a physician specializing in allergies and immunology, churns through the findings with Host Flora Lichtman.  Guest: Dr. Sharon Chinthrajah is a physician specializing in allergy and immunology at the Sean N. Parker Center at Stanford University.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Want to heal your child's eczema without steroids and save $200 this week? Click here to get started → EczemaKids.com Use code EPISODE200 to get $200 off the Eczema Elimination Method.... the COMPLETE eczema-reversal system that actually works. This offer is good for one week only and ends Tuesday, November 4th, 2025. If your child's ever had an allergy test hoping for answers, only to walk out more confused or flaring, this episode is for you. As we celebrate 200 episodes (and my birthday week!), I'm breaking down what allergy tests actually measure, why kids with eczema often react badly, and how to tell the difference between true, serious IgE allergies and immune overload. We'll talk about why scratch tests and immunotherapy often do more harm than good for eczema families, what to do if your child already flared after testing, and how to start healing their skin and gut from the inside out.

ICE Video: https://www.youtube.com/watch?v=3yOqdhEEWng&t=577sTwitter: https://twitter.com/AntiWokePodcastYoutube: https://www.youtube.com/@antiwokepodcast8381/featuredTik Tok: https://www.tiktok.com/@anti_woke_podcast

Thousands of children may be avoiding peanut allergies thanks to research indicating that early exposure to—rather than avoidance of—the legume is key. Now there's reason to believe this is true for tons of allergens – and that the great “pandemic” of kid food allergies never needed to happen. Guest:  Dr. David Hill, attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia, and The Hill Lab. Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther. Learn more about your ad choices. Visit megaphone.fm/adchoices

Thousands of children may be avoiding peanut allergies thanks to research indicating that early exposure to—rather than avoidance of—the legume is key. Now there's reason to believe this is true for tons of allergens – and that the great “pandemic” of kid food allergies never needed to happen. Guest:  Dr. David Hill, attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia, and The Hill Lab. Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther. Learn more about your ad choices. Visit megaphone.fm/adchoices

Thousands of children may be avoiding peanut allergies thanks to research indicating that early exposure to—rather than avoidance of—the legume is key. Now there's reason to believe this is true for tons of allergens – and that the great “pandemic” of kid food allergies never needed to happen. Guest:  Dr. David Hill, attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia, and The Hill Lab. Want more What Next? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme, and Rob Gunther. Learn more about your ad choices. Visit megaphone.fm/adchoices

Living with constant congestion, facial pressure, or a loss of smell can make daily life exhausting. For many people, these symptoms are more than just allergies or a lingering cold. They may be signs of chronic rhinosinusitis with nasal polyps (CRSwNP). Dr. Rohit Katial joins Kortney and Dr. G to unpack what CRSwNP really is, how it develops, and why type 2 inflammation plays such a key role. Together, they explain what's happening inside the sinuses, what symptoms to look for, and when it's time to see a specialist. What we cover about CRSwNP: What CRSwNP means: Chronic rhinosinusitis with nasal polyps is long-term inflammation of the nose and sinuses that lasts 12 weeks or more. What nasal polyps are: Soft, fluid-filled sacs (often “grape” or “pea” sized) that block airflow and lead to congestion and smell loss. Why it happens: Type 2 inflammation drives CRSwNP. Immune messengers like IL-4, IL-5, and IL-13 cause swelling and fluid buildup in the nasal lining. Who it affects: CRSwNP often overlaps with asthma, allergies, or aspirin sensitivity (AERD or Samter's Triad), making symptoms worse. When to seek help: If congestion, pressure, or loss of smell lasts more than 12 weeks, see an allergist or an ENT specialist. Early care can prevent sinus damage and improve breathing and quality of life. More episodes to support CRSwNP Ep. 101: What is Type 2 Inflammation? Ep. 102: Comorbidities of Type 2 Inflammation -  Connecting the Dots Between Multiple Allergic Conditions Ep. 109: Tezepelumab & Nasal Polyps - Inside the WAYPOINT Phase III Trial ___ Made in partnership with The Allergy & Asthma Network. Thanks to AstraZeneca for sponsoring today's episode.  This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

Send us a textWelcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recent trial examining whether amiloride is noninferior to spironolactone in reducing systolic blood pressure in patients with resistant hypertension. Here we go!Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial (0:00 – 8:10).Run-in studies:Application and impact of run-in studiesApplication and Impact of Run-In Studies for the Evaluation of Statin Efficacy and SafetyThe Good Stuff (8:11 - 9:14):Trial Files: https://trialfiles.substack.com/Heme Onc Trial Files: https://hemeonctrialfiles.substack.com/Allergy & Immunology Trial Files: https://allergyimmtrialfiles.substack.com/Critical Care Trial Files: https://criticalcaretrialfiles.substack.com/Questions? Comments? Feedback? We'd love to hear from you! @roundstable @InternAtWork @MedicinePods

Anaphylaxis can happen to anyone, at any time — but when it comes to infants and toddlers, the signs, symptoms, and response can feel especially overwhelming. Do reactions look the same as in older children or adults? What about emergency steps and epinephrine dosing? To bring clarity and confidence to caregivers and the food allergy community, we're joined today by renowned allergist, Dr. Michael Pistiner, who will help clear up common questions, confusion, and fears around managing anaphylaxis in our youngest patients. Resources to keep you in the know:Allergy and Anaphylaxis Emergency PlansFAACT's Anaphylaxis ResourcesFAACT's Epinephrine Options Poster Allergy HomeYou can find FAACT's Roundtable Podcast on Apple Podcasts, Pandora, Spotify, Podbay, iHeart Radio, or wherever you listen to podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: KaleoThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

Fluent Fiction - Catalan: Chocolate, Laughter, and An Unexpected Allergy Adventure Find the full episode transcript, vocabulary words, and more:fluentfiction.com/ca/episode/2025-10-22-07-38-19-ca Story Transcript:Ca: Martí mirava la façana del Museu de la Xocolata, el cor bategant fort.En: Martí looked at the facade of the Museu de la Xocolata, his heart pounding.Ca: Les fulles de la tardor ballaven al seu voltant mentre esperava Laia i Oriol.En: The autumn leaves danced around him as he waited for Laia and Oriol.Ca: Era el 31 d'octubre, i l'aire era fresc i ple de l'aroma dolça de castanyes i panellets.En: It was October 31st, and the air was fresh and filled with the sweet aroma of chestnuts and panellets.Ca: Laia va arribar amb un somriure radiant.En: Laia arrived with a radiant smile.Ca: Els seus ulls brillaven d'emoció pel passeig.En: Her eyes sparkled with excitement for the outing.Ca: Martí sabia que Laia adorava la xocolata, i això era la seva oportunitat per impressionar-la.En: Martí knew that Laia adored chocolate, and this was his chance to impress her.Ca: Oriol es va unir a ells amb el seu típic somriure entremaliat.En: Oriol joined them with his typical mischievous grin.Ca: Van entrar junts al museu, on els va rebre una atmosfera càlida i carregada del ric aroma de cacau.En: They entered the museum together, where they were greeted by a warm atmosphere laden with the rich aroma of cocoa.Ca: Escultures de xocolata es mostraven amb elegància, i Martí volia aprofitar-ho tot per semblar un expert davant Laia.En: Chocolate sculptures were elegantly displayed, and Martí wanted to take full advantage to seem like an expert in front of Laia.Ca: "Sabies que la xocolata blanca en realitat no conté cacau?En: "Did you know that white chocolate actually doesn't contain cocoa?"Ca: ", va començar a dir, amb Oriol fent una mueca divertida darrere seu.En: he began saying, with Oriol making a funny face behind him.Ca: Van començar el tast de xocolata.En: They began the chocolate tasting.Ca: Martí va provar diverses varietats: de Madagascar, de Veneçuela, fins i tot una de Papua Nova Guinea.En: Martí tried several varieties: from Madagascar, Venezuela, even one from Papua New Guinea.Ca: La Laia somreia i assentia amb entusiasme, i Martí es va sentir com un heroi.En: Laia smiled and nodded enthusiastically, and Martí felt like a hero.Ca: Però una de les xocolates tenia un sabor estrany, i Martí va començar a sentir una lleugera picor al coll.En: But one of the chocolates had a strange taste, and Martí started to feel a slight itch in his throat.Ca: No va voler preocupar a Laia, així que va somriure i va fer veure que tot anava bé.En: Not wanting to worry Laia, he smiled and pretended that everything was fine.Ca: Oriol, sempre atent, va notar que Martí començava a posar-se vermell.En: Oriol, always attentive, noticed that Martí was starting to turn red.Ca: "Estàs bé, Martí?En: "Are you okay, Martí?Ca: Et veig una mica inflat", va bromejar, encara que amb una mica d'inquietud.En: You look a bit swollen," he joked, although with some concern.Ca: Martí va sentir que la picor es convertia en una cosa més forta.En: Martí felt the itch turning into something stronger.Ca: "Tot bé", va insistir, cada vegada més incòmode.En: "All good," he insisted, increasingly uncomfortable.Ca: La Laia es va adonar del canvi en Martí i va preguntar, preocupada, "Estàs segur que tot està bé?En: Laia noticed the change in Martí and asked, worried, "Are you sure everything is okay?"Ca: " En aquell moment, Martí va esternudar tan fort que gairebé va fer caure una figura de xocolata.En: At that moment, Martí sneezed so loudly that he almost knocked over a chocolate figure.Ca: La situació va ser tan còmica que fins i tot ell va haver de riure, tot i la picor.En: The situation was so comical that he even had to laugh, despite the itch.Ca: Oriol va córrer a la farmàcia del carrer quan Martí va admetre que necessitava antihistamínics.En: Oriol ran to the pharmacy down the street when Martí admitted he needed antihistamines.Ca: La Laia el va acompanyar fora, rient pels esternuts sorollosos que Martí no podia contenir.En: Laia accompanied him outside, laughing at the noisy sneezes Martí couldn't contain.Ca: Finalment, un cop Martí va estar millor, la Laia el va mirar amb dolcesa.En: Finally, once Martí was feeling better, Laia looked at him sweetly.Ca: "Martí, no calia que fessis tot això per mi.En: "Martí, you didn't need to do all this for me.Ca: Em quedo amb els moments reals, no amb la perfecció.En: I cherish real moments, not perfection."Ca: " Martí es va adonar que ser autèntic era millor que impressionar amb façanes.En: Martí realized that being authentic was better than impressing with facades.Ca: Amb l'aire revitalitzat i sense els resta d'al·lèrgia, van decidir anar a veure les castanyeres a la plaça.En: With revitalized air and free of allergy remnants, they decided to visit the chestnut roasters in the square.Ca: Aquesta vegada, tots tres van riure junts, planejant properes trobades sense xocolata però plenes de rialles i autenticitat.En: This time, all three laughed together, planning future meetups without chocolate but filled with laughter and authenticity. Vocabulary Words:the facade: la façanathe museum: el museuthe chestnuts: les castanyesthe aroma: l'aromaradiant: radiantto sparkle: brillarthe mischief: l'entremaliatthe sculpture: l'esculturathe itch: la picorthe throat: el collthe concern: la inquietudto sneeze: esternudarthe pharmacy: la farmàciathe antihistamines: els antihistamínicsto cherish: valorarrevitalized: revitalitzatthe remnants: les restesto plan: planificarto pretend: fer veurethe atmosphere: l'atmosferathe aroma: l'aromathe outing: el passeigthe excitement: l'emocióthe opportunity: l'oportunitatto display: mostrarthe variety: la varietatto accompany: acompanyarthe authenticity: l'autenticitatthe hero: l'heroielegant: elegant

A decade after a landmark study proved that feeding peanut products to young babies could prevent development of life-threatening allergies, new research finds the change has made a big difference in the real world. Guest: Edmond Chan - Head, Division of Allergy, Department of Pediatrics, University of British Columbia Learn more about your ad choices. Visit megaphone.fm/adchoices

New research shows that changing infant feeding guidelines has led to sharp reductions in peanut allergies among young children

Research from the last decade of food allergies, shows that updated guidance had made a real impact on the number of people with allergies. Read more about the research here  ★ Support this podcast on Patreon ★

In this episode of SHE MD Podcast, Dr. Thaïs Aliabadi and Mary Alice Haney sit down with Dr. Tania Elliott to discuss allergies, immune health, and how hormonal changes impact symptoms. They explore practical strategies to reduce allergy triggers at home, boost immune health naturally, and adopt a personalized approach to allergy care. Dr. Elliott shares insights on seasonal allergies, food allergies, and hidden allergens in daily life, while providing actionable guidance for women navigating hormonal shifts during pregnancy, menopause, or with birth control. Listen to gain evidence-based tips to improve overall health, enhance quality of life, and take control of their wellness journey. Subscribe to SHE MD Podcast for expert tips on PCOS, Endometriosis, fertility, and hormonal balance. Share with friends and visit SHE MD Podcast and Ovii for research-backed resources, holistic health strategies, and expert guidance on women's health and well-being.Sponsors:Saje: Visit Saje.com to purchase plant powered products to remedy your needs. Use Code ‘SHEMD' for 20% off sitewide and free shippingOpill: Opill is birth control in your control, and you can use code SHEMD for twenty five percent off your first month of Opill at Opill.com.iRestore: For a limited time, get a HUGE discount on the iRESTORE Elite + Illumina Face Mask Bundle with code SHEMD at iRestore.comMerit: It's time to simplify your morning (Alt: Ready to simplify your routine?). Head to meritbeauty.com and get their Signature Makeup Bag free with your first order.Peloton: Let yourself run, lift, sculpt, push, and go. Explore the new Peloton Cross Training Tread+ at onepeloton.comGetJoy: As a listener of SheMD, you'll get 50% off your first subscription order of Get Joy's Freeze Dried Raw Dog Food plus two exclusive gifts: a free scoop and a 4oz bag of treats. Shop getjoyfood.com/shemd to support your dog's gut health and overall wellnessProlon: For a limited time, you can be first in line to experience the new Next Gen at special savings. Prolon is offering SHE MD listeners 15% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program!Cymbiotika: Go to Cymbiotika.com/Shemd for 20% off plus free shippingWhat You'll LearnUnderstanding how seasonal allergies, food allergies, and intolerances differHow hormonal changes impact allergy symptoms in womenStrategies to reduce allergy triggers at home and boost immune health naturallyWhen to use at-home allergy tests safely versus consulting a professionalKey Timestamps(02:42) Dr. Tania Elliott's Introduction (05:23) Dr. Elliott's journey in allergy and immunology(08:45) Common myths about allergies and immune health(13:10) Actionable tips: reducing triggers, hormonal considerations, lifestyle adjustments(22:24) Understanding seasonal vs. food allergies and intolerances(28:05) Hormonal shifts affecting immune system and allergies in women(35:58) Microplastics and toxins(49:29) Top 3 lifestyle changes to reduce allergens and improve healthKey Takeaways Seasonal allergies, food allergies, and intolerances affect women differently, especially during hormonal changesHidden allergens in everyday life can trigger reactions without noticeLifestyle factors like sleep, stress, and gut health influence immune resiliencePersonalized allergy care is more effective than one-size-fits-all approachesAt-home allergy tests can be helpful but professional guidance is essential for accurate diagnosisGuest BioDr. Tania Elliott is a dual board-certified physician specializing in Internal Medicine and Allergy/Immunology. She serves as a Clinical Instructor at NYU Langone Health and is a spokesperson for the American College of Allergy, Asthma, and Immunology. Dr. Elliott empowers people to take control of their health through actionable advice and personalized care. She is also the founder of Modern Medical, a consulting firm providing strategic support across healthcare sectors.Links:

Dr. Mitch Shulman can be heard every weekday morning at 7:50 on The Andrew Carter Morning Show.

Millions of people around the world were impacted by a major internet outage today, but an expert says it could have been much worse. Senators are returning to Capitol Hill today, with no compromise in sight to end the shutdown. President Donald Trump says tariffs are coming for Colombia. The FBI is investigating a “suspicious” hunting stand near Florida's Air Force One landing zone. Plus, some good news on preventing peanut allergies. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Navigating food allergies is tough enough, but adding family dynamics to the mix can make things even more complicated. When loved ones don't understand you or your child's allergies or dismiss the rules meant to keep them safe, it can lead to conflict, hurt feelings, and stress for everyone involved. Kortney and Dr. Payel Gupta sit down with psychologist Dr. Amanda Whitehouse to talk about how families can find common ground when emotions run high. Together, they unpack what it means to stay regulated in difficult conversations, how to set healthy boundaries with family members, and why understanding different coping styles can help prevent conflict before it starts. What we cover about communication and boundary-setting for food allergy families: Coping styles and conflict: Learn how different stress responses, such as “fight” versus “flight,” shape how partners, parents, and relatives react to food allergy challenges. Staying calm and regulated: Understand how your body reacts to stress and how recognizing those signals can help you stay grounded during tough conversations. Setting and holding boundaries: Get practical tips for explaining what feels safe, keeping communication clear, and responding calmly when others push back. Working together as a team: Whether it's with your partner, kids, or extended family, learn how to support each other and stay united when emotions rise. Bridging family differences: Explore ways to include children and siblings in allergy safety, and approach older relatives with patience and compassion when views or communication styles differ. ___ Made in partnership with The Allergy & Asthma Network. Thanks to Genentech for sponsoring today's episode.  This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

In this episode, host Dr. Douglas Reh speaks with Dr. Masayoshi Takashima. They discuss the recently published Original Article: “3-Year Outcomes of Temperature-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve in Patients With Chronic Rhinitis.” The full manuscript is available as open access in the International Forum of Allergy and Rhinology. Listen and subscribe for […]

Episode 38 - Countdown to Chicago: What's Ahead at the CPNP Nutrition SymposiumIn this episode of Nutrition Pearls: the Podcast, host Nikki Misner speaks with Dr. Brock Williams and Tamara Sims Dorway about the upcoming CPNP Nutrition Symposium at the annual NASPGHAN meeting on November 6-8th in Chicago, Illinois. Brock Williams is a Registered Dietitian and Postdoctoral Research Fellow at the University of British Columbia (Vancouver, Canada). Over the past 10 years, he has worked as both a clinical and research dietitian at the Hospital for Sick Children (SickKids; Toronto), and at BC Children's Hospital (Vancouver) in areas such as Translational Medicine, Gastroenterology, and Allergy. His major clinical and research interests lie in micronutrients and childhood feeding (human milk feeding, complementary feeding and the prevention and treatment of food allergy). Brock currently serves as President-elect of CPNP. Tamara Sims Dorway is an experienced Registered Dietitian who is a board-certified specialist in pediatric nutrition. She is an integral part of the multidisciplinary team at the Center for Digestive Health and Nutrition at Arnold Palmer Hospital, where she provides comprehensive nutritional care for children and families facing a range of GI challenges. She has previously served on the CPNP planning committee for NASPGHAN and was the communications co-chair for POWER (Pediatric Obesity Weight Evaluation Registry).  She enjoys volunteering in her community and spending time with her family. She is the current CPNP Program ChairNutrition Pearls is supported by an educational grant from Mead Johnson Nutrition.Resources:NASPGHAN 2025 Annual Meeting NASPGHAN 2025 App Produced by: Corey IrwinNASPGHAN - Council for Pediatric Nutrition Professionalscpnp@naspghan.org

Chris and Amy explore the expansion of video gaming by adults; Chris wants to get a hold of the allergy index numbers; and leaves are just not changing colors this year.

We end the futile struggle, embrace the toxins, and become one with our mould brethren.The full episode is available to Patreon subscribers (2 hours, 38 minutes).Join us at: https://www.patreon.com/DecodingTheGurusSupplementary Material 3800:00 Intro02:54 Boomer Matt reacts to Twitter videos07:31 Shellenberger and Tucker discuss the 9/11 Files12:42 Eric's Google Ngram Investigations17:08 Vindication on the Elephant Graveyard22:00 Eric's ARC lecture goes viral25:24 Andrew Huberman is NOT a phrenologist...29:06 Eric Weinstein vs. Piers Morgan33:44 Everyone knows Eric is a serious thinker46:09 Peterson is taken out of the Gurusphere by Demons and Toxic Mould52:09 Gurus and Bespoke Alternative Health57:00 Social Contagion Hypocrisy01:02:55 Toxic Mould Symbiosis?01:04:46 Pewdiepie, Diogenes, and the Seeker Mindset01:16:14 The Wisdom of the Ancients01:21:01 The Meaning Crisis and Christian Pivots01:22:29 Konstantin Kisin's surprising Christian pivot01:25:17 The best person Konstantin ever met (not Francis)01:30:22 The Fifth Column Agrees with Megyn Kelly 88% of the time01:33:07 Megyn Kelly explains how the Democrats crossed the line and must pay01:41:35 Intellectual Clerics for MAGA01:43:16 Slightly Adversarial libertarians for hire01:47:00 Drew Pavlou and Fluid Populism01:50:17 Two Varieties of Online Derangement: Noah Smith's Hot Takes01:53:57 Need for Attention = Desire for Virality01:57:23 Status Seeking Networkers vs Paul Bloom02:01:27 Reflecting on the Al Murray Interview02:02:22 The struggle of podcasters02:04:52 Paul Bloom: The best person in the world?02:06:00 Mike Israetel's Thesis Controversy02:10:30 What does a PhD mean?02:16:55 David Deutsch visits Curt Jaimungal02:22:32 The Dangers of Doubling Down: Pirate Software02:23:32 Hasan Piker and Shock Collar-gate02:27:15 Matt's Take on Shock Collars02:33:51 Dystopia Update: Putin wants Trump to win the Nobel Prize02:37:11 OutroSourcesShellenberger and Tucker discuss the CIA's role in 9/11Grok pressing Eric to get specificThe Elephant GraveyardViral post about Eric's ARC speech on scienceHuberman's phrenology endorsementJordan Peterson's Health Update from MikhailaChris Williamson: It's time to talk about my health.Chang, C., & Gershwin, M. E. (2019). The myth of mycotoxins and mold injury. Clinical Reviews in Allergy & Immunology, 57(3), 449–455.Borchers, A. T., Chang, C., & Eric Gershwin, M. (2017). Mold and human health: A reality check. Clinical Reviews in Allergy & Immunology, 52(3), 305–322.

On this episode of Eczema Out Loud, Dr. Ari Zelig, an allergist and immunologist out of Charleston, South Carolina's Charleston ENT and Allergy, talks eczema, allergies, and the relationship between the two. We cover food allergies, environmental allergies and treatments. We also do some myth-busting and answer your community-sourced questions. What did you think of this episode? Consider writing us a review!National Eczema Association (NEA)NEA is the driving force for an eczema community fueled by knowledge, strengthened through collective action and propelled by the promise for a better future.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://nationaleczema.org/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Contact us: ⁠podcast@nationaleczema.org

Fatigue? Inflammation? Brain fog? Aging? Pain? Stress? Weakness? https://bit.ly/48tVRyq   Ready to discover what's really holding you back from feeling your best?

We are joined by Carina Venter, PhD — gut diversity expert, researcher, and registered dietitian—to unpack how gut health influences people living with food allergies. She'll also share insights on using everyday foods as a powerful tool to help prevent food allergies in infants.Resources to keep you in the know:FAACT's Latest Research of Food Allergy PreventionFAACT's What to Do to Protect Against Food AllergiesLet's Grow Happy Feeding Allergen GuideYou can find FAACT's Roundtable Podcast on Apple Podcasts, Pandora, Spotify, Podbay, iHeart Radio, or wherever you listen to podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: GenentechThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

Imagine a child diagnosed with a life-threatening food allergy – how does this impact their mental health and family dynamics? In this episode, we explore the often-overlooked psychological aspects of food allergies. Licensed therapist Tamara Hubbard, MA, LCPC, shares insights on helping patients and families navigate anxiety, risk assessment, and social challenges. We discuss strategies for clinicians to address mental health concerns during allergy diagnoses, manage family conflicts, and recognize when to refer for counseling. Learn how to empower food allergy patients to live fully while staying safe, balancing avoidance with quality of life, and fostering resilience in children and parents alike. For episode resources and references, visit: https://www.thermofisher.com/phadia/us/en/resources/immunocast/mental-health-strategies-food-allergy-patients-tamara-hubbard.html?cid=0ct_3pc_05032024_9SGOV4

On this episode of Food Allergy Talk, I welcome Amy Graves, author of The Hidden Consumer: Uncovering the power of health-conscious buyers. Amy is allergic to mold, grass, birch, pet dander... as well as foods, including both corn and soy.When discovering her allergies she was living in MN but due to not being able to buy food in grocery stores had to move to CA.Her journey of discovering her allergies was complicated. At the time corn was not tested for and she had to figure it out on her own for over 2 years. Today we are going to learn about Amy's story, and how her journey with food allergies let to her book, The Hidden Consumer: Uncovering the Power of Health-Conscious Buyers.Amy's Bio:Amy Graves is a passionate advocate for health-conscious consumers and the founder of Hidden Consumers Consulting. After discovering her own severe sensitivities and allergies, Amy embarked on a journey to understand the hidden challenges faced by those with similar health concerns. With a background in marketing and a commitment to education, she has become a leading voice for consumers seeking safe and clean products. Through her work, Amy helps brands better understand and meet the needs of this influential demographic, empowering them to create safer, more inclusive products that resonate with today's health-savvy shoppers. Her book, The Hidden Consumer: Uncovering the Power of Health-Conscious Buyers, is available wherever books are sold!Links:Amy's Website: https://hiddenconsumersconsulting.com/Book Website with Retail Links: https://thehiddenconsumer.com/other-places-to-purchaseJoin My Private Facebook Group to connect, support and share: https://www.facebook.com/groups/FoodAllergyPI/Read My Articles on WebMD: https://blogs.webmd.com/food-allergies/lisa-horneThe Everything Nut Allergy Cookbook: https://www.simonandschuster.com/authors/Lisa-Horne/190009636The Food Allergy Talk Podcast: https://foodallergypi.com/the-food-allergy-talk-podcast/Food Allergy P.I. Blog: https://foodallergypi.comX: @foodallergypi & @fatalkpodcastInstagram: https://www.instagram.com/foodallergypi/ and https://www.instagram.com/foodallergytalk/ TikTok: https://www.tiktok.com/@foodallergypiEmail: foodallergypi@gmail.com

Fluid overload is a common problem in critically ill patients. In this episode, Dr. Sergio Zanotti discuss recognizing and managing fluid overload in the ICU with guest Dr. Michael J. Connor, Jr., a practicing intensivist and nephrologist. Dr. Connor is a Professor and Senior Physician of Critical Care Medicine & Nephrology at the Divisions of Pulmonary, Allergy, Critical Care, and Sleep Medicine and Renal Medicine at Emory University School of Medicine. Additionally, he serves as the director of critical care nephrology at the Emory Critical Care Center at Grady Memorial Hospital. Additional resources European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3- fluid removal at de-escalation phase. Intensive Care Med 2025: https://pubmed.ncbi.nlm.nih.gov/40828463/ Optimizing Fluid Therapy in the Critically Ill. International Fluid Academy website – 2025: https://www.fluidacademy.org/2025/01/17/optimising-fluid-therapy-in-the-critically-ill-introduction-to-7d/ Fluid overload in the ICU: evaluation and management. R. Claure-Del Granado and R. L. Mehta. BMC Nephrology 2016: https://pubmed.ncbi.nlm.nih.gov/27484681/ Books and music mentioned in this episode: Think Again: The Power of Knowing What You Don't Know. By Adam Grant: https://bit.ly/4gZvz9c RUSHMERE. By Mumford & Sons: https://bit.ly/473FzKc

This week on The Jubal Show, the crew dives into hilariously awkward moments that will make you cringe and laugh at the same time! From singing to a business voicemail by accident, to allergy struggles before a cute date, and even a near-naked encounter with an Amazon delivery guy and his Ninja stars. Tune in for outrageous stories, relatable fails, and the wacky antics of your favorite cast — guaranteed to brighten your week and keep you entertained! You can find every podcast we have, including the full show every weekday right here…➡︎ https://thejubalshow.com/podcasts The Jubal Show is everywhere, and also these places: Website ➡︎ https://thejubalshow.com Instagram ➡︎ https://instagram.com/thejubalshow X/Twitter ➡︎ https://twitter.com/thejubalshow Tiktok ➡︎ https://www.tiktok.com/@the.jubal.show Facebook ➡︎ https://facebook.com/thejubalshow YouTube ➡︎ https://www.youtube.com/@JubalFresh Support the show: https://the-jubal-show.beehiiv.com/subscribeSee omnystudio.com/listener for privacy information.

For decades, allergists have focused on blocking what happens outside the mast cell: histamine, IgE, and interleukins. But now, there's a new way to stop allergic inflammation before it even starts: by targeting what happens inside the cell with BTK Inhibitors. Dr. Payel Gupta and Kortney are joined by Dr. Matthew Giannetti to unpack what BTK actually does and why inhibiting it represents an exciting breakthrough in allergy and immunology. Together, they explore how BTK inhibitors work, why this inside-the-cell approach is different from anything before, and what it could mean for people living with chronic spontaneous urticaria (CSU). What the episode covers about BTK inhibitors: BTK explained: Bruton's tyrosine kinase is a pivotal “last step” before mast-cell degranulation. How BTK inhibitors work: Blocking BTK can stop histamine release downstream of many outside triggers. The science: Why BTK binding is irreversible for each molecule and how the body “re-makes” BTK over time. Safety in brief: A look at petechiae (small pinpoint spots), what to monitor, and how shared decision-making guides treatment choices. The future of BTK inhibitors: Exploring their potential role in other allergic conditions.    ____ Made in partnership with The Allergy & Asthma Network. Thanks to Novartis for sponsoring today's episode.  This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

RE-RELEASE: This episode was originally released in February 2025.In this episode, Dr. Anthony Fauci joins A'ndre for an in-depth conversation about his decades-long career in public health and his experiences leading the U.S. response to some of the world's most pressing infectious disease challenges. Dr. Fauci reflects on his early work during the HIV/AIDS crisis, the evolution of treatments that saved millions of lives, and his role in launching PEPFAR, one of the most significant global health initiatives in history. He  discusses his leadership at the National Institute of Allergy and Infectious Diseases (NIAID), navigating crises such as Ebola, Zika, H1N1, anthrax, and COVID-19, while working alongside multiple U.S. presidents to shape national and global health policies.Beyond his career in government, Dr. Fauci shares his thoughts on the intersection of public health and national security, the growing challenges of vaccine skepticism and misinformation, and the vital role of institutions like the NIH and CDC in protecting public health. He also highlights the major health threats that remain overlooked in mainstream discourse. Now a professor at Georgetown University, Dr. Fauci reflects on his transition to academia and the importance of training the next generation of medical leaders in an era of evolving global health challenges.You can purchase his recent memoir, On Call, here.

Making sure kids get the nutrition they need is always important—but for families managing food allergies, it can feel especially challenging when safe food options are limited. We're joined by FAACT Medical Advisory Board Member, Owner of ALnourished, and Registered Dietitian, Alison Cassin, MS, RD, LD, to talk about how to meet essential nutritional needs, smart ways to swap ingredients, and when supplements may be helpful. Together, we'll explore practical strategies for building a healthy, balanced life with food allergies.Resources to keep you in the know:FAACT's Reading Labels for AllergensFAACT's Food Allergies, Healthy Snacks for All Ages - PodcastFAACT's Powerhouse Eating for Teens and College Students with Food Allergies Pt. 1 - PodcastFAACT's Powerhouse Eating for Coaches and Caregivers Managing Students with Food Allergies Pt. 2 - PodcastALnourished Website - Alison Cassin, Food Allergy NutritionYou can find FAACT's Roundtable Podcast on Apple Podcasts, Pandora, Spotify, Podbay, iHeart Radio, or wherever you listen to podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: DBV TechnologiesThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

Detectable HIV-1 RNA (viral load) can seem very worrisome for people living with HIV who are receiving antiretroviral therapy (ART) and for their healthcare professionals. Tune in to learn how Brian R. Wood, MD, differentiates HIV-1 RNA “blips” from persistent low-level viremia and from virologic failure, and how he handles each scenario.Presenter:Brian R. Wood, MDProfessor of MedicineDivision of Allergy and Infectious DiseasesUniversity of WashingtonSeattle, WashingtonLink to full program: https://bit.ly/4nS7rYEGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The U.S. government is now in its second week of a shutdown—with the FDA having paused acceptance of all new drug applications for the duration. But it was business as usual at the CDC, which adopted the recent recommendations of its newly revamped advisory committee on chickenpox and COVID-19 vaccines. And another senior leader, National Institute of Allergy and Infectious Diseases Director Jeanne Marrazzo, was fired last week, after filing a whistleblower report.  Across the country, cell and gene therapy leaders arrived in Phoenix for the annual Meeting on the Mesa, as the space remains in a state of flux—with regulatory and M&A momentum being stalled by commercial and market challenges. Takeda, for one, is looking to offload its cell therapy platform after years of hefty investment.  President Donald Trump's long-awaited tariffs did not hit on Oct. 1 as promised. But in the face of the looming levies, Pfizer signed a drug pricing deal with the White House that provides a three-year exemption. Amgen appears to be climbing onboard as well, announcing that its lipid-lowering drug Repatha will be available at a steep discount. These moves are all well and good for Big Pharma players, but a recent report from CRB reveals most smaller biopharma companies are not planning any investments to offset tariffs.  In our weekly weight loss segment, Skye Bioscience's cannabinoid receptor 1-targeting candidate nimacimab failed to outpace placebo in reducing body weight but elicited “intriguing synergy” in combination with Novo Nordisk's Wegovy, according to William Blair analysts. And regulatory documents shed further light on Pfizer's $4.9 billion takeover of Metsera, in which the New York pharma beat out two higher bidders for the promising obesity startup.  Finally, make sure to check out The 5 Most Powerful Women in Biopharma and BioSpace's inaugural 40 Under 40, highlighting 40 young leaders who have made an impact on the biopharma industry.  

Did you know that peanut-triggered anaphylaxis jumps by 85% during Halloween? This startling statistic underscores the critical need for healthcare providers to address food allergy management proactively. This episode tackles the complex interplay between food allergies and Halloween festivities, offering insights into accurate diagnosis, emotional impact assessment, and practical safety strategies. We discuss the importance of allergen component-resolved diagnostics in risk stratification, the underutilized mental health resources for food allergy patients, and innovative community initiatives like the Teal Pumpkin Project. Learn how to guide your patients towards a safe, inclusive Halloween experience while optimizing your allergy management approach year-round. Resources and references: https://www.thermofisher.com/phadia/us/en/resources/immunocast/halloween-food-allergy-management-peanut-tree-nut.html?cid=0ct_3pc_05032024_9SGOV4

Allergy woes, haircuts, and fall weather. Drawtober art prompts, dieting, and the gift of Hades II. A Cult of the Lamb trivia quiz. Cozy games (Peak, Thank Goodness You're Here), job-hunting, AI video tools like Sora, and family chats about politics, empathy, and nuance. Grumpiness, kindness, and knocking over Girl Scouts, all on this weeks Monday Show. Hosted on Acast. See acast.com/privacy for more information.

Allergy woes, haircuts, and fall weather. Drawtober art prompts, dieting, and the gift of Hades II. A Cult of the Lamb trivia quiz. Cozy games (Peak, Thank Goodness You're Here), job-hunting, AI video tools like Sora, and family chats about politics, empathy, and nuance. Grumpiness, kindness, and knocking over Girl Scouts, all on this weeks Monday Show. Hosted on Acast. See acast.com/privacy for more information.

Are you one of the 52 million people in the U.S. who experience chronic pain daily? In It Doesn't Have to Hurt: Your Smart Guide to a Pain-Free Life, the practicing neurosurgeon and CNN's multiple Emmy Award-winning chief medical correspondent debunks the myth that most pain problems can only be fixed with a drug or procedure, and argues that we have agency with how to respond. In conversation with Dr. Anthony Fauci, the former Director of the National Institute of Allergy and Infectious Diseases at the NIH from 1984 to 2022.  This program was held on September 11, 2025. Watch this conversation on YouTube.

Seeing your allergist on a screen instead of in the office might feel strange at first, but for many people with allergies, telehealth isn't just convenient.  it's effective. In this episode, we sit down with telemedicine pioneer Dr. Jay Portnoy to explore how virtual allergy care works, what it can and can't do, and how it's helping patients get the care they need without the wait or the long drive. Dr. Portnoy shares over two decades of experience leading allergy telemedicine programs in rural areas and explains how remote care has grown from a fringe idea into a standard part of allergy care. He and Dr. G also discuss the benefits for both patients and clinicians. So how do you know when telehealth is enough and when it's not? What we cover in our episode about virtual allergy care and telemedicine: How does telemedicine work for allergy patients? Learn how video visits and asynchronous tools are making care faster and easier, especially in rural or underserved areas. Telemendine limitations. We break down when in-person care is still needed, like for food challenges, skin tests, or urgent symptoms. Privacy and safety in virtual care. From HIPAA-compliant platforms to quiet spaces at home or in schools, we talk about how to keep your virtual visit just as private as a clinic one. How testing works with telemedicine. Telehealth doesn't mean skipping tests. Many can be ordered remotely and done at a local lab or clinic near you. The future of allergy care. Hear how virtual care is shifting toward patient choice, whether you want to video call, send a message, or still come in. ___ Made in partnership with The Allergy & Asthma Network. Thanks to Genentech for sponsoring today's episode.  This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

Benadryl's active ingredient, diphenhydramine, is now considered outdated and unsafe, with researchers urging that it be removed from over-the-counter use The drug causes strong sedation, impaired memory, and slower reaction times, with studies showing it affects driving performance more than alcohol Older adults face lingering grogginess for up to 18 hours, while children risk unpredictable reactions, including agitation, coma, or heart problems if overdosed Other countries have already restricted access, and medical authorities warn against its use in children, highlighting safer alternatives and lifestyle strategies Natural approaches like vitamin C, quercetin, whole foods, restorative sleep, and stress management help balance histamine and reduce allergy symptoms without dangerous side effects

Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In today's video I unpack amlexanox—an old anti-inflammatory/allergy drug with surprising metabolic effects. I share my first encounter with it in the research-chem world, what I noticed subjectively, and then dive into mechanisms (IKKε/TBK1 inhibition, catecholamine resensitization, beige fat), rodent data, the Phase 2 human trial (150 mg/day), safety, dosing, who seems to respond best, and how I'm stacking it inside Bio Ignite. If your goal is fat loss with stubborn adipose inflammation, this is worth understanding.0:00 - Welcome + what today's video covers0:28 - How I first found “AM Lox” browsing catalogs1:06 - Cycling off SLU-PP-332 and first personal trial1:40 - Noticing dryness/ab definition; early under-dosing2:12 - 2025 “sugar diet” + hunting for FGF21 boosters2:40 - Finding data that amlexanox increases FGF213:02 - Literature dosage (100–150 mg) vs my early dose3:38 - Why I think it's a useful fat-loss rotation tool4:24 - Channel/hosting update + where to find my videos5:08 - Slides start: what amlexanox is/was used for6:00 - Core mechanism: IKKε/TBK1 → PDE3B → cAMP resistance7:16 - IL-6→STAT3 hepatic signaling + beigeing via FGF218:30 - Big-picture benefits: inflammation, insulin sensitivity, glycemia10:32 - Human data: Phase 2 trial (150 mg/day x 12 weeks)11:10 - Modest/variable weight change; who improved most12:37 - Practical takeaways: glycemia, liver fat, insulin sensitivity14:12 - Dosing in practice (50 mg caps, TID = 150 mg/day)15:12 - Responder phenotype: high adipose inflammation16:00 - Who benefits most + variability at similar body fat17:56 - Study roll-up and mechanism recap18:52 - Final thoughts, use-cases, and product note (Bio Ignite)19:54 - Thank you + where to grab the peptide cheat sheetWhat You'll LearnWhy amlexanox can “release the brakes” on fat-burning by inhibiting IKKε/TBK1 and restoring cAMP/catecholamine responsiveness.How it raises IL-6 transiently in adipose, activates STAT3 in the liver, suppresses gluconeogenesis, and increases FGF21 to promote beige fat programs.The mouse vs. human gap: robust fat loss in mice; in humans, clearer improvements in A1c, fructosamine, liver fat, insulin sensitivity—especially when adipose inflammation is high.Dosing used in the Phase 2 trial: 50 mg TID (total 150 mg/day) for 12 weeks.Safety snapshot: no serious AEs attributed to amlexanox in metabolic trials; most common was a transient rash.Timestamps (exact to the transcript)What you'll learn

These diseases - West Nile Virus, Lyme disease, and Rocky Mountain Spotted Fever - are named for the places where outbreaks happened. But they're also all things you get from being bitten by mosquitoes or ticks. Research: Balasubramanian, Chandana. “Rocky Mountain Spotted Fever (RMSF): The Deadly Tick-borne Disease That Inspired a Hit Movie.” Gideon. 9/1/2022. https://www.gideononline.com/blogs/rocky-mountain-spotted-fever/ Barbour AG, Benach JL2019.Discovery of the Lyme Disease Agent. mBio10:10.1128/mbio.02166-19.https://doi.org/10.1128/mbio.02166-19 Bay Area Lyme Foundation. “History of Lyme Disease.” https://www.bayarealyme.org/about-lyme/history-lyme-disease/ Caccone, Adalgisa. “Ancient History of Lyme Disease in North America Revealed with Bacterial Genomes.” Yale School of Medicine. 8/28/2017. https://medicine.yale.edu/news-article/ancient-history-of-lyme-disease-in-north-america-revealed-with-bacterial-genomes/ Chowning, William M. “Studies in Pyroplasmosis Hominis.("Spotted Fever" or "Tick Fever" of the Rocky Mountains.).” The Journal of Infectious Diseases. 1/2/1904. https://archive.org/details/jstor-30071629/page/n29/mode/1up Elbaum-Garfinkle, Shana. “Close to home: a history of Yale and Lyme disease.” The Yale journal of biology and medicine vol. 84,2 (2011): 103-8. Farris, Debbie. “Lyme disease older than human race.” Oregon State University. 5/29/2014. https://science.oregonstate.edu/IMPACT/2014/05/lyme-disease-older-than-human-race Galef, Julia. “Iceman Was a Medical Mess.” Science. 2/29/2012. https://www.science.org/content/article/iceman-was-medical-mess Gould, Carolyn V. “Combating West Nile Virus Disease — Time to Revisit Vaccination.” New England Journal of Medicine. Vol. 388, No. 18. 4/29/2023. https://www.nejm.org/doi/full/10.1056/NEJMp2301816 Harmon, Jim. “Harmon’s Histories: Montana’s Early Tick Fever Research Drew Protests, Violence.” Missoula Current. 7/20/2020. https://missoulacurrent.com/ticks/ Hayes, Curtis G. “West Nile Virus: Uganda, 1937, to New York City, 1999.” From West Nile Virus: Detection, Surveillance, and Control. New York : New York Academy of Sciences. 2001. https://archive.org/details/westnilevirusdet0951unse/ Jannotta, Sepp. “Robert Cooley.” Montana State University. 10/12/2012. https://www.montana.edu/news/mountainsandminds/article.html?id=11471 Johnston, B L, and J M Conly. “West Nile virus - where did it come from and where might it go?.” The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses vol. 11,4 (2000): 175-8. doi:10.1155/2000/856598 Lloyd, Douglas S. “Circular Letter #12 -32.” 8/3/1976. https://portal.ct.gov/-/media/departments-and-agencies/dph/dph/infectious_diseases/lyme/1976circularletterpdf.pdf Mahajan, Vikram K. “Lyme Disease: An Overview.” Indian dermatology online journal vol. 14,5 594-604. 23 Feb. 2023, doi:10.4103/idoj.idoj_418_22 MedLine Plus. “West Nile virus infection.” https://medlineplus.gov/ency/article/007186.htm National Institute of Allergy and Infectious Disease. “History of Rocky Mountain Labs (RML).” 8/16/2023. https://www.niaid.nih.gov/about/rocky-mountain-history National Institute of Allergy and Infectious Disease. “Rocky Mountain Spotted Fever.” https://www.niaid.nih.gov/diseases-conditions/rocky-mountain-spotted-fever Rensberger, Boyce. “A New Type of Arthritis Found in Lyme.” New York Times. 7/18/1976. https://www.nytimes.com/1976/07/18/archives/a-new-type-of-arthritis-found-in-lyme-new-form-of-arthritis-is.html?login=smartlock&auth=login-smartlock Rucker, William Colby. “Rocky Mountain Spotted Fever.” Washington: Government Printing Office. 1912. https://archive.org/details/101688739.nlm.nih.gov/page/ Sejvar, James J. “West Nile virus: an historical overview.” Ochsner journal vol. 5,3 (2003): 6-10. https://pmc.ncbi.nlm.nih.gov/articles/PMC3111838/ Smithburn, K.C. et al. “A Neurotropic Virus Isolated from the Blood of a Native of Uganda.” The American Journal of Tropical Medicine and Hygiene. Volume s1-20: Issue 4. 1940. Steere, Allen C et al. “The emergence of Lyme disease.” The Journal of clinical investigation vol. 113,8 (2004): 1093-101. doi:10.1172/JCI21681 Steere, Allen C. et al. “Historical Perspectives.” Zbl. Bakt. Hyg. A 263, 3-6 (1986 ). https://pdf.sciencedirectassets.com/281837/1-s2.0-S0176672486X80912/1-s2.0-S0176672486800931/main.pdf World Health Organization. “West Nile Virus.” 10/3/2017. https://www.who.int/news-room/fact-sheets/detail/west-nile-virus Xiao, Y., Beare, P.A., Best, S.M. et al. Genetic sequencing of a 1944 Rocky Mountain spotted fever vaccine. Sci Rep 13, 4687 (2023). https://doi.org/10.1038/s41598-023-31894-0 See omnystudio.com/listener for privacy information.

Multiple food allergies are a daily stressor for millions of families. From avoiding social events to fearing accidental exposures, it can feel like living in a constant state of alert. Until recently, there were no FDA-approved treatments that targeted more than one allergen at a time. In this episode, we break down the study: “Omalizumab for the Treatment of Multiple Food Allergies,” published in 2024 in the New England Journal of Medicine. Known as the OUtMATCH trial, it's the first large-scale study to show that omalizumab (Xolair), a biologic already used for asthma and hives, may help people with multiple food allergies by raising the threshold for reactions. We explain how omalizumab works by blocking IgE, the antibody that triggers allergic reactions, and how the study measured changes in reaction thresholds (the amount of an allergen a person can ingest before reacting). We also explore the trial design, results, safety profile, and what all of this means for the day-to-day management of food allergies. What we cover in our episode about OUtMATCH trial How omalizumab works to prevent allergic reactions: Learn how blocking IgE increases the amount of allergen needed to trigger symptoms, offering protection from small, accidental exposures. Who qualified for the OUtMATCH trial and why: Find out which patients were included and how eligibility impacted outcomes. What success looked like in this study: Understand how researchers defined protection across multiple allergens. Why not everyone responded the same to omalizumab: Explore the variability in results and what it means for clinical care. What else the study found beyond food challenges: Hear about safety findings, quality of life data, and the open-label extension.

There's something up with Courtney's allergies // Mahomes anointed GOAT too early and golf FOMO is a real thing // Curtis doubts Gonzo's "setback," thinks his absence is contract related //

Is that penicillin or amoxicillin allergy real? Probably not. In this episode, we explore how to assess risk, talk to parents, and refer for delabeling. You'll also learn what happens in the allergy clinic, why the label matters, and how to be a better antimicrobial steward. Learning Objectives Describe the mechanisms and clinical manifestations of immediate and delayed hypersensitivity reactions to penicillin, including diagnostic criteria and risk stratification tools such as the PEN-FAST score. Differentiate between low-, moderate-, and high-risk penicillin allergy histories in pediatric patients and identify appropriate candidates for direct oral challenge or allergy referral based on current evidence and guidelines. Formulate an evidence-based approach for evaluating and counseling families in the Emergency Department about reported penicillin allergies, including when to recommend outpatient referral for formal delabeling. Connect with Brad Sobolewski PEMBlog: PEMBlog.com Blue Sky: @bradsobo X (Twitter): @PEMTweets Instagram: Brad Sobolewski References Khan DA, Banerji A, Blumenthal KG, et al. Drug Allergy: A 2022 Practice Parameter Update. J Allergy Clin Immunol. 2022;150(6):1333-1393. doi:10.1016/j.jaci.2022.08.028 Moral L, Toral T, Muñoz C, et al. Direct Oral Challenge for Immediate and Non-Immediate Beta-Lactam Allergy in Children. Pediatr Allergy Immunol. 2024;35(3):e14096. doi:10.1111/pai.14096 Castells M, Khan DA, Phillips EJ. Penicillin Allergy. N Engl J Med. 2019;381(24):2338-2351. doi:10.1056/NEJMra1807761 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review.JAMA. 2019;321(2):188–199. doi:10.1001/jama.2018.19283 Transcript Note: This transcript was partially completed with the use of the Descript AI and the Chat GPT 5 AI  Welcome to PEM Currents, the Pediatric Emergency Medicine podcast. As always, I'm your host, Brad Sobolewski, and today we are taking on a label that's misleading, persistent. Far too common penicillin allergy, it's often based on incomplete or inaccurate information, and it may end up limiting safe and effective treatment, especially for the kids that we see in the emergency department. I think you've all seen a patient where you're like. I don't think this kid's really allergic to amoxicillin, but what do you do about it? In this episode, we're gonna break down the evidence, walk through what actually happens during de labeling and dedicated allergy clinics. Highlight some validated tools like the pen FAST score, which I'd never heard of before. Preparing for this episode and discuss the current and future role of ED based penicillin allergy testing. Okay, so about 10% of patients carry a penicillin allergy label, but more than 90% are not truly allergic. And this label can be really problematic in kids. It limits first line treatment choices like amoxicillin, otitis media, or penicillin for strep throat, and instead. Kids get prescribed second line agents that are less effective, broader spectrum, maybe more toxic or poorly tolerated and associated with a higher risk of antimicrobial resistance. So it's not just an EMR checkbox, it's a label with some real clinical consequences. And it's one, we have a role in removing. And so let's understand what allergy really means. And most patients with a reported penicillin allergy, especially kids, aren't true allergies in the immunologic sense. Common misinterpretations include a delayed rash, a maculopapular, or viral exum, or benign, delayed hypersensitivity, side effects, nausea, vomiting, and diarrhea. And unverified childhood reactions that are undocumented and nonspecific. Most of these are not true allergies. Only a very small subset of patients actually have IgE mediated hypersensitivity, such as urticaria, angioedema, wheezing, and anaphylaxis. These are super rare, and even then they may resolve over time without treatment. If a parent or sibling has a history of a penicillin allergy, remember that patient might actually not be allergic, and that is certainly not a reason to label a child as allergic just because one of their first degree relatives has an allergy. So right now, in 2025, as I'm recording this episode, there are clinics like the Pats Clinic or the Penicillin Allergy Testing Services at Cincinnati Children's and in a lot of our peer institutions that are at the forefront of modern de labeling. Their approach reflects the standard of care as outlined by the. Quad ai or the American Academy of Allergy, asthma and Immunology and supported by large trials like Palace. And you know, you have a great trial if you have a great acronym. So here's what happens step by step. So first you stratify the risk. How likely is this to be a true allergy? And that's where a tool like the pen fast comes. And so pen fast scores, a decision rule developed to help assess the likelihood of a true penicillin allergy based on the patient's history. The pen in pen fast is whether or not the patient has a self-reported history of penicillin allergy. They get two points if the reaction occurred in the past five years. Two points if the reaction is anaphylaxis or angioedema. One point if the reaction required treatment, and one point if the reaction was not due to testing. And so you can get a total score of. Up to six points. If you have a score of less than three. This is a low risk patient and they can be eligible for direct oral challenge. A score greater than three means they're higher risk and they may require skin testing. First validation studies show that the PEN FFA score of less than three had a negative predictive value of 96.3%. Meaning a very, very low chance of a true allergy. And this tool has been studied more extensively in adults, but pediatric specific adaptations are emerging, and they do inform current allergy clinic protocols. But I would not use this score in the emergency department just to give a kid a dose of amoxicillin. So. For low risk patients, a pen fast score of less than three or equivalent clinical judgment clinics proceed with direct oral challenge with no skin testing required. The protocol is they administer one dose of oral amoxicillin and they observe for 62 120 minutes monitoring for signs of reaction Urticaria. Respiratory symptoms or GI upset. This approach is safe and effective. There was a trial called Palace back in 2022, which validated this in over 300 children. In adolescents. There were no serious events that occurred. De labeling was successful in greater than 95% of patients. And skin tested added no benefit in low risk patients. So if the child tolerates this dose, then you can remove that allergy immediately from the chart. Parents and primary care doctors will receive a summary letter noting that the challenge was successful and that there's new guidance. Children and families are told they can safely receive all penicillins going forward. And providers are encouraged to document this clearly in the allergy section of the EMR. So you're wondering, can we actually do this in the emergency department? Technically, yes, you can do what you want, but practically we're not quite there yet. So we'd need clearer risk stratification tools like the Pen fast, a safe place for monitoring, post challenge, clinical pathways and documentation support. You know, a clear way to update EMR allergy labels across the board and involvement or allergy or infectious disease oversight. But it's pretty enticing, right? See a kid you diagnose otitis media. You think that their penicillin allergy is wrong, you just give 'em a dose of amox and watch 'em for an hour. That seems like a pretty cool thing that we might be able to do. So some centers, especially in Canada and Australia, do have some protocols for ED or inpatient based de labeling, but they rely on that structured implementation. So until then, our role in the pediatric emergency department is to identify low risk patients, avoid over document. Unconfirmed reactions and refer to allergy ideally to a clinic like the pets. So who should be referred and good candidates Include a child with a rash only, especially one that's remote over a year ago. Isolated GI symptoms. Parents unsure of the details at all. No history of anaphylaxis wheezing her hives, and no recent serious cutaneous reactions. I would avoid referring and presume that this allergy is true. If they've had recent anaphylaxis, they've had something like Stevens Johnson syndrome dress, or toxic epidermolysis necrosis. Fortunately, those are very, very rare with penicillins and there's a need for penicillin during the ED visit without allergy backup. So even though we don't have an ED based protocol yet. De labeling amoxicillin or penicillin allergy can start with good questions in the emergency department. So here's one way to talk to patients and families. You can say, thanks for letting me know about the amoxicillin allergy. Can I ask you a few questions to better understand what happened? This is gonna help us decide the safest and most effective treatment for your child today, and then possibly go through a process to remove a label for this allergy that might not be accurate. You wanna ask good, open-ended questions. What exactly happened when your child took penicillin or amoxicillin? You know, look for rash, hives, swelling, trouble breathing, or anaphylaxis. Many families just say, allergic, when the reaction was just GI upset, diarrhea or vomiting, which is not an allergy. How old was your child when this happened? Reactions that occurred before age of three are more likely to be falsely attributed. How soon after taking the medicine did the reaction start? Less than one hour is an immediate reaction, but one hour to days later is delayed. Usually mild and probably not a true allergy. Did they have a fever, cold or virus at that time? Viral rashes are often misattributed to antibiotics, and we shouldn't be treating viruses with antibiotics anyway, so get good at looking at ears and know what you're seeing. And have they taken similar antibiotics since then? Like. Different penicillins, Augmentin, or cephalexin. So if they said that they were allergic to amoxicillin, but then somehow tolerated Augmentin. They're not allergic. If a patient had rash only, but no hive swelling or difficulty breathing, no reaction within the first hour. It occurred more than five years ago or before the kid was three. And especially if they tolerated beta-lactam antibiotics. Since then, they're a great candidate for de labeling and I would refer that kid to the allergy clinic. Generally, they can get them in pretty darn quick. Alright, we're gonna wrap up this episode. Most kids labeled penicillin allergic or amoxicillin allergic, or not actually allergic to the medication. There are some scores like pen fasts that are validated tools to assess risk and support de labeling. Direct oral challenge for most patients is safe, efficient, and increasingly the standard of care. There are allergy clinics like the Pats at Cincinnati Children's that can dela children in a single visit with oral challenges alone, needing no skin testing, and emergency departments can play a key role in identifying and referring these patients and possibly de labeling ourselves in the future. Well, that's all for this episode on Penicillin Allergy. I hope you learn something new, especially how to assess whether an allergy label is real, how to ask the right questions and when to refer to an allergy testing clinic. If you have feedback, send it my way. Email, comment on the blog, a message on social media. I always appreciate hearing from you all, and if you like this episode, please leave a review on your favorite podcast app. Really helps more people find the show and that's great 'cause I like to teach people stuff. Thanks for listening for PEM Currents, the Pediatric Emergency Medicine podcast. This has been Brad Sobolewski. See you next time.

What if the thing holding back our evolution wasn't the Unviverse, but our alignment with it?In this Q&A episode, Thom explores the subtle early signal of misalignment, why formulaic living dulls creativity, and how the unknown became the forge of the human brain. Thom also challenges us to make our behaviors more evolutionary, offers a cautionary message about our modern archives, and shares a bold, simple law you won't forget.Episode Highlights[00:45] Q - How do we make evolution exponential as opposed to gradual?[00:55] A - The Sweet Spot Is…[05:03] Looking for Frictionless Flow[07:18] The Dangers of Formulaic Thinking[10:40] An Allergy to Embracing the Unknown[12:33] The Unknown is the Frontier that Built the Human Brain[15:30] An Invitation to Do Something Different[17:54] Q - What exactly are we to harvest? Knowledge or resources?[19:11] A - Breaking the Shackles of Our Brain[21:35] The Greatest Wasted Resource on Earth[24:01] Use It Or Lose It[26:43] Brain-Power Problems[30:39] The Great Good Fortune of Being a Vedic Meditator[32:31] An Outlet for Social Relevance[36:14] Q - Are our current evolutionary theories still relevant?[36:54] A - Big Crunch is Making a Comeback[39:34] Individuality is Cosmic[42:12] Thank Goodness for the Asteroid Strike[46:03] Unreliable Archives of the Human Experience[52:14] Q - Should we harvest more interactions with each other?[52:35] A - Meditators Have the Capacity to be Interactors[56:06] The Joy of Person-to-Person Human Connectivity[58:28] Commonality is a Great Uniting Force[01:00:41] Q - Does the Veda state that evolution is Cosmic Law?[01:00:59] Evolve. Full Stop.Useful Linksinfo@thomknoles.com https://thomknoles.com/https://www.instagram.com/thethomknoleshttps://www.facebook.com/thethomknoleshttps://www.youtube.com/c/thomknoleshttps://thomknoles.com/ask-thom-anything/