Podcasts about phage

Send us a textDr. Jessica Sacher, Ph.D. is Co-Founder of Phage Directory ( https://phage.directory/ ), a global network of phage researchers from more than 80 countries, where she directs its phage-sourcing and community-building efforts, including coordinating over 50 phage-finding efforts, where a network of more than 1,300 members of the global phage community volunteer their time and lab space to identify active phages for patients.Dr. Sacher is also a Staff Scientist at Stanford University School of Medicine ( https://profiles.stanford.edu/jessica-sacher ) in Dr. Paul Bollyky's lab where she leads strategy & lays groundwork for a new phage-based therapeutic development and delivery center at Stanford, developing manufacturing processes and quality control pipelines for clinical-grade phage biologics, as well as evaluating phages as gene and peptide delivery vectors for eukaryotic and microbial cells.Dr. Sacher was previously a member of Prof. Jon Iredell's group in Sydney, Australia as a postdoctoral research scientist for the Phage Australia project where she developed and streamlined Phage Australia's phage selection, biobanking, and manufacturing process, to make phage therapy available for patients Australia-wide and eventually beyond.Dr. Sacher received her PhD in Microbiology and Biotechnology in 2018 from the University of Alberta, Canada.Dr. Sacher is also Founder, Editor, Writer of Capsid & Tail: the phage community newsletter, a weekly report on bacteriophage news and researchImportant Episode Links -  Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches - Published March 3, 2025  - The Journal of Clinical Investigation -https://www.jci.org/articles/view/187996The Citizen Phage Library (https://citizenphage.com) #JessicaSacher #PhageDirectory #Bacteriophage #StanfordUniversity #Campylobacter #SteffanieStrathdee #Microbiology #PhageBiobank #Biofilms #AMR #AntimicrobialResistance #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

“Phage” 30th-anniversary reflections Chakotay, Kim, and Neelix beam into caves on a rogue planetoid to search for dilithium; but they come back empty-handed. Not only do they have no dilithium, Neelix left something even more important behind: his lungs. With these vital organs now in the possession of mysterious aliens, the ship's new self-proclaimed chef will have to postpone the opening of his kitchen and stay in sickbay, where the Doctor has fitted him with holographic lungs. As the crew search for the aliens and try to retrieve Neelix's organs, Janeway is confronted with an unexpected moral dilemma. After being stalked by Vidiians, you may never listen to that famous song by The Police the same way again. In this episode of To The Journey, hosts C Bryan Jones and Matthew Rushing continue our 30th-anniversary retrospective that will take you through all of Star Trek: Voyager, one episode at a time. In this installment, we discuss “Phage” and the introduction of a fascinating alien race in a story that hits right at the heart of Star Trek. Chapters Intro (00:00:00) A Species with Depth (00:02:52) A Neelix Problem? (00:08:34) Cooking Up Storytelling (00:17:01) Ripe for Serialization? (00:21:07) Real-Life Science (00:25:30) Wrath and Compassion (00:28:05) The Doctor and AI Evolution (00:36:02) Kes Finds Purpose (00:42:44) Final Thoughts and Ratings (00:44:26) Closing (00:48:22) Hosts C Bryan Jones and Matthew Rushing Production C Bryan Jones (Editor and Executive Producer) Matthew Rushing (Executive Producer)

LOL (LOSS OF LUNGS). It's the 30th anniversary of Star Trek: Voyager's debut. Bryan & Shereese play Trek Marry Kill with "Phage," the episode that introduces us to the gnarly Vidiians, who mark the occasion by stealing Neelix's lungs! Is the episode compelling Trek or a drama set in a carnival? The grades begin at (25:41).

TWiV discusses an outbreak of influenza H5N1 that killed over half of the great cats at a Washington sanctuary, origin and cross-species transmission of bat coronaviruses in China, and the diverse and abundant phages that enter cells via receptors encoded on conjugative plasmids. Hosts: Vincent Racaniello, Rich Condit, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 H5N1 virus kills great cats at Washington sanctuary (CNN) Macroevolution of bat coronaviruses in China (Nat Comm) EcoHealth Alliance funding suspended (Science) Conjugative plasmids support diverse and abundant phages (Nat Comm) Letters read on TWiV 1181 Timestamps by Jolene. Thanks! Weekly Picks Rich – Pareidolia (wiki) Jolene – Pathways to Science database Vincent – Wendy Carlos and Switched-On Bach Listener Picks Arjan – Gutsick Gibbon's YouTube channel Alan – 2024 Nobel Prize Lectures in Chemistry Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

TWiV reviews the appearance of poliovirus in Europe, mystery disease in DRC, global burden of Chikungunya, viruses of parasitic nematodes that induce antibody responses in vertebrate hosts, and picobirnaviruses, do they infect eukaryotes or prokaryotes? Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2025 Write your senators about RFK Jr Support science education at MicrobeTV Poliovirus in Europe (WHO) DRC mystery disease (Reuters) Global burden of chikungunya (BMJ Global Health) RNA viruses of parasitic nematodes (Nat Micro) Picobirnaviruses encode bacterial lysins (PNAS) Prokaryotic ribosome binding site in picobirnavirus genome (Virology) Letters read on TWiV 1175 Timestamps by Jolene. Thanks! Weekly Picks Alan – Sondehub and radiosonde hunting Jolene – Book “10 to 25: The Science of Motivating Young People” By David Yeager Vincent – Dr. Vinay Prasad “Sabotaging RFK Jr's Confirmation Will Increase Vaccine Hesitancy” & “Doctors Criticizing RFK Jr. Paved the Way for His Ascendancy” Listener Picks Syl – Foldscope Jennifer – minutiae Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

121124 2nd HR Melissa On What Is A Phage- You Better Know This Before The Next Scamdemic by Kate Dalley

This episode covers:In this episode, we discuss the importance of skin health, the crucial role of the skin microbiome, how technology can address skin concerns at their root cause, and so much more.A scientist by background, Yug received his training at distinguished academic institutions including Johns Hopkins University (Ph.D.) and University of California, San Francisco. As a microbiologist and synthetic biologist with a background in organic chemistry, Yug has spent his career working at the intersection of microbiome research, synthetic biology, and next-generation sequencing. This research led to his desire to develop the next generation of live biologic products to treat chronic microbial diseases.While developing this technology, Yug discovered an application to tackle acne which he quickly realized is a serious problem without a safe, high-quality solution on the market. So he set out to build Phyla and the 3-Step Phyla Phage System, to meet the unmet consumer need for clean, effective skincare and acne-fighting products.Phyla's breakthrough technology uses a naturally occurring organism called bacteriophage (phage, for short) that specifically targets the overgrowth of acne bacteria. This phage has been shown to flourish in healthy skin, but is nearly absent on acne-affected skin. Yug decided to democratize this revolutionary organism, put it in a bottle, and make it accessible to everyone who needs it.Links mentioned during this episode:Phyla Biotics: https://phyla.comLyons' Share Instagram: www.instagram.com/thelyonsshareJoin Megan's Newsletter: www.thelyonsshare.org/newsletter

В этом выпуске: обсудили кто чему научился за неделю, миграцию на Kubernetes, инструмент для деплоя Phage, обновление PostgreSQL со сломанный ABI, а также темы наших слушателей. [00:02:03] Чему мы научились за эту неделю [00:45:48] Migration to K8s, short story (Art) [01:11:59] Deployment tool — Phage (Art) [01:24:01] PostgreSQL 17.1, 16.5, 15.9, 14.14, 13.17, and 12.21… Читать далее →

Dr. Jeng Her, Founder and CEO of AP Biosciences, is developing T-Cube bispecific antibodies that can target cancer cells and engage T-cells to kill them more effectively and safely than existing treatments. The company is focused on treating hard-to-treat cancers such as HER2-positive breast cancer, lung cancer, head and neck cancer, and pancreatic cancer. The T-Cube bispecific antibodies use CD137 instead of CD3 to activate T-cells, which can lead to better efficacy and safety compared to other T-cell engager antibodies. Jeng explains, "So why not just take two, let's say, monospecific antibodies and then put them together and give them to the patient in the combination therapy? Instead, we wanted to develop bispecific antibodies by fusing two antibodies together into one single molecule. So what's the advantage? Eventually, what it comes down to is the therapeutic window of bispecific antibodies. This means you want your antibodies, your bispecific, to have better efficacy, better safety, and sometimes lower cost of goods since you are only expressing or producing one single drug molecule. So, the way we look at bispecific and the real advantage is not just the additive effect. It's not even the synergistic effect, which means we would like our bispecific antibodies to do something combination therapy cannot do. And that's the value of our bispecific antibodies." "Basically, we have two technology platforms. The first one is an antibody phage display library. We call it Omni-mAb. This library is a live library, which means it has more than 100 billion antibody sequences. That's a collection of the 100 billion sequences. And whatever antigen, whatever conformation of the structure of antigens you have, you could isolate a very high-affinity antibody from the library in probably 4-6 weeks."  #APBiosciences #Antibody #Biotech #Bispecific #ImmunoOncology #Cancer #SolidTumors APBioInc.com Download the transcript here

Dr. Jeng Her, Founder and CEO of AP Biosciences, is developing T-Cube bispecific antibodies that can target cancer cells and engage T-cells to kill them more effectively and safely than existing treatments. The company is focused on treating hard-to-treat cancers such as HER2-positive breast cancer, lung cancer, head and neck cancer, and pancreatic cancer. The T-Cube bispecific antibodies use CD137 instead of CD3 to activate T-cells, which can lead to better efficacy and safety compared to other T-cell engager antibodies. Jeng explains, "So why not just take two, let's say, monospecific antibodies and then put them together and give them to the patient in the combination therapy? Instead, we wanted to develop bispecific antibodies by fusing two antibodies together into one single molecule. So what's the advantage? Eventually, what it comes down to is the therapeutic window of bispecific antibodies. This means you want your antibodies, your bispecific, to have better efficacy, better safety, and sometimes lower cost of goods since you are only expressing or producing one single drug molecule. So, the way we look at bispecific and the real advantage is not just the additive effect. It's not even the synergistic effect, which means we would like our bispecific antibodies to do something combination therapy cannot do. And that's the value of our bispecific antibodies." "Basically, we have two technology platforms. The first one is an antibody phage display library. We call it Omni-mAb. This library is a live library, which means it has more than 100 billion antibody sequences. That's a collection of the 100 billion sequences. And whatever antigen, whatever conformation of the structure of antigens you have, you could isolate a very high-affinity antibody from the library in probably 4-6 weeks."  #APBiosciences #Antibody #Biotech #Bispecific #ImmunoOncology #Cancer #SolidTumors APBioInc.com Listen to the podcast here

Bacteriophage technology is being used to address acne, eczema, and other dysbiotic skin concerns. Some microbiology companies are working with endolysins (proteins produced by phages), others are focused on formulating skincare with phages themselves.  This week on the CosmoFactory podcast, we consider possible cosmetic industry applications for bacteriophage technology. Our guest is Milan Bunata, Business Director of FagoFarma, a biotech company specialized in phage-based preparations for use in the cosmetics, pharma, and veterinary industries. Based in the Czech Republic, FagoFarma was established in 2013. And this year, in an effort to both educate consumers about phage-based skincare and to gather feedback, the company launched a consumer acne care product called FagoCare Gel.  If you appreciate this episode, SHARE it with a colleague, SUBSCRIBE to the CosmoFactory podcast & please LEAVE US A REVIEW today. With your help, even more cosmetic industry professionals can discover the inspiring interviews we share on CosmoFactory! ABOUT CosmoFactoryBeauty industry stakeholders listen to the CosmoFactory podcast for inspiration and for up-to-date information on concepts, tactics, and solutions that move business forward. CosmoFactory – Ideas to Innovation is a weekly interview series for cosmetics and personal care suppliers, finished product brand leaders, retailers, buyers, importers, and distributors. Each Tuesday, CosmoFactory guests share experiences, insights, and exclusive behind-the-scenes details—which makes this not only a must-listen B2B podcast but an ongoing case study of our dynamic industry. Guests are actively working in hands-on innovation roles along the beauty industry supply chain; they specialize in raw materials, ingredients, manufacturing, packaging, and more. They are designers, R&D or R&I pros, technical experts, product developers, key decision makers, visionary executives. HOST Deanna UtroskeCosmetics and personal care industry observer Deanna Utroske hosts the CosmoFactory podcast. She brings an editorial perspective and a decade of industry expertise to every interview. Deanna is also Editor of the Beauty Insights newsletter and a supply-side positioning consultant. She writes the Global Perspectives column for EuroCosmetics magazine, is a former Editor of CosmeticsDesign, and is known globally for her ability to identify emerging trends, novel technologies, and true innovation in beauty. A PRODUCTION OF Cosmoprof Worldwide BolognaCosmoFactory is the first podcast from Cosmoprof Worldwide Bologna, taking its place among the best B2B podcasts serving the global beauty industry.   Cosmoprof Worldwide Bologna is the most important beauty trade show in the world. Dedicated to all sectors of the industry, Cosmoprof Worldwide Bologna welcomes over 250,000 visitors from 150 countries and regions and nearly 3,000 exhibitors to Bologna, Italy, each year. It's where our diverse and international industry comes together to build business relationships and to discover the best brands and newest innovations across consumer beauty, professional beauty, and the entire supply chain. The trade show includes a robust program of exclusive educational content, featuring  executives and key opinion leaders from every sector of the cosmetics, fragrance, and personal care industry. Cosmoprof Worldwide Bologna is the most important event of the Cosmoprof international network, with exhibitions in Asia (Hong Kong), the US (Las Vegas and Miami), India (Mumbai) and Thailand (Bangkok). Thanks to its global exhibitions Cosmoprof connects a community of more than 500,000 beauty stakeholders and 10,000 companies from 190 countries and regions. Learn more today at Cosmoprof.com 

Matters Microbial #63: A Symphony of Cyanobacteria October 30, 2024 Today, Dr. Nathan Algren, Associate Professor of Biology at Clark University, joins the #QualityQuorum to discuss the centrality of cyanobacteria to our biosphere, the viruses that prey upon them, and his interests in outreach and science-oriented art. Host: Mark O. Martin Guest: Nathan Ahlgren Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode An overview of the cyanobacteria. An overview of Prochlorococcus. An overview of marine bacteriophages. The Great Oxidation Event Cyanobacteria are thought to have radically changed our planet 2.5-3.5 billion years ago by producing oxygen through photosynthesis. In essence, they and other microbes are the original terraformers. The Purple Earth Hypothesis Photosynthesis as we know it, using chlorophyll, may have evolved after another way of doing photosynthesis, with retinal that looks purple. This means that our planets and other ‘younger' planets may look or have looked purple rather than green. Self-assembly of viral capsids, as modeled by 3D-printed parts (Art Olson) TED talk from Penny Chisholm on Prochlorococcus Co-occurring Synechococcus ecotypes occupy four major oceanic regimes defined by temperature, macronutrients and iron  Study showing how different populations of Synechococcus occupy different niches and regions of the oceans according to their adaptations to temperature and nutrients. Long-term stability and Red Queen-like strain dynamics in marine viruses  Study showing turnover of strains within relatively stable phage populations. Viral treadmills in the ocean—running to stand still  Companion ‘behind the paper' article. Diverse Marine T4-like Cyanophage Communities Are Primarily Comprised of Low-Abundance Species Including Species with Distinct Seasonal, Persistent, Occasional, or Sporadic Dynamics  Paper showing cyanophage ‘species' have different time patterns in the oceans. Rapid diversification of coevolving marine Synechococcus and a virus Study showing stable co-existence and co-evolution of a single Synechococcus host and phage over time. The emergence of resistance hosts and phage that overcome them demonstrate the principles of the Red Queen hypothesis and phage-host ‘arms race'. Present and future global distributions of the marine Cyanobacteria Prochlorococcus and Synechococcus Figure from this paper is in the presentation. Shows modeled distributions of Pro and Syn across the globe. They also use this to estimate a ~25% contribution of Pro and Syn to global net primary productivity in the oceans. Link to 3D prints that Dr. Ahlgren made an are available on NIH page Some resources on how to 3D protein structures: I like this guide on the practical guide of how to do actually to do it (going from PDB to print files): A link to another resource for 3D printing of protein structures. Dr. Ahlgren's faculty website. Dr. Ahlgren's laboratory website with many fascinating links. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

Matters Microbial #62: Should I Stay, or Should I Go—How Bacteriophage are Released from Host Cells October 23, 2024 Today, Dr. Jolene Ramsey, of the Biology Department of Texas A&M University and Affiliate of the Center for Phage Technology, joins the #QualityQuorum to discuss how bacteriophages release themselves from host cells, her efforts to teach students to work with the primary literature, and her own path to the microbial sciences.   Host: Mark O. Martin Guest: Jolene Ramsey Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A truly wonderful reminder video about bacteriophages. A link with a 3D printer design of capsid model pieces (personally, I am really interested in making one of these!). A video demonstrating how the capsid model pieces self assemble—something like real viruses can? An essential book about bacteriophage authored by my late friend Merry Youle. A fine book describing how bacteriophages can be used to fight bacterial diseases. This “first person” book by #MattersMicrobial podcast guest Steffanie Strathdee about how she was able to use bacteriophages to save her husband's life is a must read. A link to the Citizen's Phage Library. A link to the truly fabulous (yes, I am jealous I am not part of this program) CURE program SEA-PHAGES and SEA-GENES for undergraduate students. A remarkable illustration of T4 bacteriophage bursting from host cells by the scientist-artist David Goodsell. The organization that designed Dr. Ramsey's laboratory logo. A link to the Clinical Genome Curation for Human Genes.   A link to the CACAO website for biocuration competition. A recent Ramsey lab mini-review on phage classification. A link to the Center for Phage Technology. The Ramsey lab Instagram page. The Ramsey lab YouTube channel. Dr. Ramsey's laboratory website. Dr. Ramsey's faculty website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

I don't know how to tell you all this, but our podcast has been infected by a virus... a pernicious strain of Star Trek called Voyager. It's potentially treatable, but we may now be prone to bouts of intense boredom and creative frustration. Unfortunately, while it's possible we end up with something more benign and even fulfilling, our odds aren't terribly good. All we can do is wait and see how the virus takes hold of us in this sickening episode of Star Trek: Voyager. Episode discussion starts at 18:52. This is episode 3/17 in our look at Voyager. Hosted by Jaron Hatch, Aren Hatch, & Leah Medley. Email us at storiedstartrek@gmail.com Visit our Discord Server at https://discord.gg/6ynq25Zvkh

Today, Dr. Cynthia Silveira of the Department of Biology at Miami University joins the #QualityQuorum to discuss her research team's efforts to explore how bacterial viruses interact with their host cells from coral reefs to other planets! In addition, Dr. Silveira will discuss her microbiological path and a course she teaches on virology. Host: Mark O. Martin Guest: Cynthia Silveira Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A video about marine bacteriophages and the role they play in ecological systems. A fine article about the role that bacteriophages can have in marine environments. An essay suggested that marine viruses may influence global climate. A link to the wonderful book, “Coral Reefs in a Microbial Sea.” Forest Rohwer's laboratory website. The role of a retrovirus in the development of the mammalian placenta.   A bacterial role in snow making, using the commercial product “Snomax.”   A “faculty spotlight” essay on Dr. Silveiro. Dr. Silveiro's laboratory website. Dr. Silveiro's faculty website.   Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Polio vaccination in Gaza (Reuters) Zoonotic viruses in farmed fur animals (Nature) HPV vaccination and cancer rates (JAMA Net Open) 40 kb RNA genome without error correction (PNAS) Stopping the phage tape measure protein (Nat Commun) Tail assembly interference (Nat Commun) Letters read on TWiV 1151 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum Vincent – The collapse of bat populations led to more than a thousand infant deaths Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Matters Microbial #56: Marine Microbial Echoes of Evolution September 11, 2024 Today, Dr. Carolina Martinez Gutierrez of the Department of Earth Science at the University of California Santa Barbara joins the #QualityQuorum to discuss her research team's efforts to unravel how ancient microbes thrived in the early oceans of Earth's history . . . and to sing the praises of marine microbiology! Host: Mark O. Martin Guest: Carolina Martinez Gutierrez Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode An overview of the microbiome of the ocean and geochemistry. A description of likely conditions on Ancient Earth. An essay about the Great Oxidation Event—the event that changed our entire planet. An article by Dr. Martinez Gutierrez and colleagues discussing how phylogenomics can help dissect microbial evolution without fossils. An overview of Prochlorococcus, one of the microbes Dr. Martinez Gutierrez discussed. A wonderful video about Prochlorococcus and a remarkable scientist. An overview of Pelagibacteri ubique (SAR11), one of the microbes Dr. Martinez Gutierrez discussed. An article about the work of Dr. Martinez Gutierrez and her research interests while a postdoctoral scholar The departmental website for Dr. Martinez Gutierrez The laboratory website for Dr. Martinez Gutierrez's research group. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

We're hurtling towards a post-antibiotic world, as the overuse of antibiotics has given rise to dangerous drug-resistant bacteria. Can we fight back using viruses as weapons? An obscure medical therapy uses certain viruses called bacteriophages to treat infection. For a century attempts to turn phage-therapy into a life-saving treatment have faltered, but today there's renewed interest in this approach. Can we use phages to forestall the antibiotic crisis?  Guests: Claas Kirchhelle – Medical historian at the University College, Dublin Tom Ireland – Journalist, editor of The Biologist and author of “The Good Virus: The Amazing Story and Forgotten Promise of the Phage” Steffanie Strathdee – Associate Dean of Global Health Sciences at the University of California San Diego Tom Patterson – Professor of psychiatry at the University of California San Diego Featuring music by Dewey Dellay and Jun Miyake You can get early access to ad-free versions of every episode by joining us on Patreon. Thanks for your support! Big Picture Science is part of the Airwave Media podcast network. Please contact advertising@airwavemedia.com to inquire about advertising on Big Picture Science.   Learn more about your ad choices. Visit megaphone.fm/adchoices

We're hurtling towards a post-antibiotic world, as the overuse of antibiotics has given rise to dangerous drug-resistant bacteria. Can we fight back using viruses as weapons? An obscure medical therapy uses certain viruses called bacteriophages to treat infection. For a century attempts to turn phage-therapy into a life-saving treatment have faltered, but today there's renewed interest in this approach. Can we use phages to forestall the antibiotic crisis?  Guests: Claas Kirchhelle – Medical historian at the University College, Dublin Tom Ireland – Journalist, editor of The Biologist and author of “The Good Virus: The Amazing Story and Forgotten Promise of the Phage” Steffanie Strathdee – Associate Dean of Global Health Sciences at the University of California San Diego Tom Patterson – Professor of psychiatry at the University of California San Diego Featuring music by Dewey Dellay and Jun Miyake You can get early access to ad-free versions of every episode by joining us on Patreon. Thanks for your support! Big Picture Science is part of the Airwave Media podcast network. Please contact advertising@airwavemedia.com to inquire about advertising on Big Picture Science.   Learn more about your ad choices. Visit megaphone.fm/adchoices

Join us as we host Dr. Yug Varma, co-founder of Phyla, who shared the scientific journey and innovative solutions behind the brand. Dr. Varma's extensive knowledge of phage technology and microbiome research, combined with his academic background, led to the creation of Phyla. He identified a significant gap in acne treatment, noting that most existing solutions are based on outdated technologies. This realization, coupled with a desire to innovate in a stagnant market, fueled his mission to develop a novel approach to acne care.Dr. Varma highlighted the limitations of traditional acne treatments, such as benzoyl peroxide, Accutane, and retinoids. These treatments often come with side effects and are not always effective in the long term. He emphasized the need for more advanced and targeted solutions, pointing out that the current market fails to address the root causes of acne effectively. Central to Phyla's innovation is phage technology. Dr. Varma explained that phages, or bacteriophages, are viruses that specifically target and kill bacteria. Research has shown that phages targeting C-acnes bacteria are more prevalent on healthy skin than acne-prone skin. This insight led to the development of Phyla's products, which utilize phages to selectively target and eliminate acne-causing bacteria without disturbing the beneficial bacteria on the skin.Dr. Varma reassured listeners that phages are less likely to induce resistance compared to antibiotics. Phyla's extensive testing has shown that their phages do not quickly induce resistance, making them a robust solution for long-term acne management. He discussed the effectiveness of Phyla's products, noting that they deliver results relatively quickly. For hormonal acne, improvements can be seen within days or a week. For cystic acne, the technology gradually rebalances the microbiome, reducing inflammation and preventing relapses. This targeted approach minimizes side effects and provides a sustainable solution for acne sufferers. Dr. Varma advocates for a minimalist approach to skincare, focusing on key products that promote skin health without overwhelming the consumer. Phyla offers a streamlined product line, emphasizing quality and efficacy over quantity.Tune in to learn more!Explore PHYLA Hosted on Acast. See acast.com/privacy for more information.

Happy Tuesday Everyone and Welcome back to the latest episode of Phage Therapy Today! Phage science is awesome, the business is growing, and the numbers on paper are looking great. But along with this excitement, we must realize the end goal is to save lives and improve clinical outcomes. The truth is phage therapy is still very far from accessible to the general public today. There are many reasons for this, and the lack of information and community available to the general public and doctors is definitely a major contributing factor. Because phage therapy is not yet the standard of care and is considered experimental, doubt from doctors and patients can delay the start of phage therapy treatment. In this week's episode, Christopher Schaffer shares his story of how he saved his own life by going on a journey where he took the lead in finding a cure for his MDR infection. He did tons of research on his own, reaching out to all the help  he could get, and navigating through difficult situations related to Covid and the Ukraine war. The amount of courage, determination, and faith he demonstrated is awe-inspiring. Let's give it a listen! To bridge this gap, I am unofficially announcing the formation of a nonprofit organization led by Christopher Schaffer, Professor Irene Chen, and myself. Our aim is to create a community for patients and doctors looking into phage therapy. The goal is to provide information on success stories from past patients to build trust in phage therapy, connect with therapeutic resources, and provide support to all going through AMR infections, ensuring you are not alone out there. As a first step, I would like people to re-post, @doctors, and patients who require phage therapy resources to join our Discord group at: https://discord.gg/gtrX5ZpE. We would also like everyone else passionate about phage therapy to join and comment in the “volunteers” and “general” channels only.

Our Review Of Star Trek: Voyager - Phage This episode made us feel out of breath as Dereth de-lungs our opinions and shows that early Voyager episodes can pack a few surprises! ---- *Trek Time is a 100% Charity Supporting Channel!* Check Our Website: https://trek-time.com Join The Discord: https://discord.gg/zKKHKwBB98 Follow Us On Twitch: https://twitch.tv/TrekTime Subscribe To Our Podcast: https://anchor.fm/s/256197a0/podcast/rss Follow Us On Twitter: https://twitter.com/TrekTime_ Follow Us On Bluesky: https://bsky.app/profile/trektime.bsky.social Email: trek.time.charity@gmail.com

In this special episode I spoke with an international guest from my native country, Republic of Georgia, and global ambassador of a critical alternative solution against tough chronic infections and antimicrobial resistance on behalf of a global center of excellence in bacteriophage therapy, discovered over 100 years ago. My guest, Davit Sturua, Doctor of Business Administration, Public Health and Medical Tourism expert, is the director of the Eliava Phage Therapy Center, a global leader in real-world, clinical, research, and commercial experience with naturally occurring bacteriophage treatments. He discusses the Georgian center's 100-year old history and evolution, its extensive experience treating patients across 84 countries, explains the current global public health problem, and provides an update along with rationale on the recent growth in clinical studies investigating phage therapy across the globe in this part 1 of 2 episodes on this topic. Watch this episode with English subtitles to learn about how you, your friends, family, healthcare payers and experts, healthcare providers, patients and their loved ones can consider alternative options via telemedicine or in person to treat chronic, tough bacterial infections or prevent antimicrobial resistance. Stay tuned for the next episode (part 2) on this topic with my guest Dr. Dea Nizharadze, Chief Physician at the Eliava Phage Therapy Center, who delves deeper into the typical course of treatment, patient journey, and various scientific attributes of phage treatments. 0:00 Introduction 0:08 Introduction in English 2:19 Special Guest Mr. Davit Sturua, Director of Eliava Phage Therapy Center Introduction in English 4:34 Episode Introduction in Georgian (English subtitles) 4:53 Overview of Part 1: Overview of 100-year history of Eliava Phage Therapy Center, its advances, growth, current goals and Part 2: Scientific Rationale for phage treatment, appropriate patients, typical course of treatment, and access to care for patients worldwide 5:54 Davit's personal inspiration and history at the Eliava Center 10:27 How is EPTC raising awareness about phage therapy outside of Georgia? The center has treated patients from 84 different countries in 2023 alone. The majority of patients internationally who obtain care from EPTC suffer from various antibiotic-resistant or chronic infections. 12:20 5 million patients die from antimicrobial resistantce every year - underestimation, with tens of millions of deaths projected by 2050 13:04 Future Scientific and Commercial goals of Eliava Center to expand globally, standardize phage production to meet GMP standards, conduct randomized clinical studies and secure access for patients worldwide 15:23 Challenges in scaling phage production and quality standardization. Georgia is currently a global leader in commercial production of bacterial phage treatments. While only a few years ago there were only a handful of clinical studies conducted globally, currently there are over 50 clinical studies in 2023-2024 alone over the past year being conducted in the United States alone. Similarly, other European countries, particularly Great Britain are also actively pursuing and advancing clinical research in bacteriophage therapies. Government and research funding in phage treatment is therefore continuing to grow rapidly. 18:33 Final Greetings - Conclusion of Part 1. Invitation to partner across Europe and the U.S. with the Eliava Phage Therapy Center

An investigation into a strange disappearance leads to the unveiling of far stranger things lurking in the woods of Boyle County. This is the most recent story in the Contagion Cycle, which began with A Scratching at the Door and included Intruder and Scrubgrass. While listening to these isn't necessary to follow the plot of Spider's Phage, they give a lot of context and extra detail about the events leading to this tale. Music by CO.AG Music

Join Marshal and Keith as they trek into the Delta Quadrant with Captain Kathryn Janeway, Commander Chakotay, Tuvok, B'Elanna Torres and the rest of the crew and of the starship Voyager.   Stranded, they meet the Caretaker, theTalaxians, Kazon, Ocampa, Vidiians, and Baneans as they begin their perilous 75-year trek home looking for ways to speed their journey.To download, right-click here and then click SaveJoin the Journey Into Patreon to get extra episodes and personal addresses, plus other extras and rewards.Episode Title               Timecode00:03:19                       "Caretaker"00:28:08                       "Parallax"00:34:13                       "Time and Again"00:40:38                       "Phage"00:45:32                       "The Cloud"00:51:38                       "Eye of the Needle"00:57:07                        "Ex Post Facto" To comment on this or any episode:Send comments and/or recordings to journeyintopodcat@gmail.comLook for JourneyInto on Instagram, Threads, Facebook, or even X

8. Mai 1995: Die Voyager-Crew gerät ein zweites Mal mit den von der Phage gebeutelten Vidiianern aneinander – da ist es nur passend, dass sich die noch junge Serie für Star-Trek-Verhältnisse schonungslos auf das Territorium klassischen Horrors begibt. Außerdem ist die Halb-Klingonin B'Elanna Torres reif für eine eingehende Charakterstudie, was mittels einer medizinisch bemerkenswerten Zweiteilung gelingt. In Deutschland: Von Angesicht zu Angesicht, auf VHS am 24. April 1996, ausgestrahlt am 13. September 1996.

Phage therapy has gained a lot of traction but the challenges created by this approach have not been properly assessed at a big scale. We often read about therapy successes on isolated cases but, rarely, we read or hear about failures. AAC recently published a case series of patients who failed phage therapy. Today, we will discuss this topic with the principal investigator on the research. Topics discussed: Phage therapy as an approach for MDR bacteria. The challenges of phage therapies. Issues that can influence the success of phage therapy Guest: Saima Aslam, MBBS. Director, Solid Organ Transplant Infectious Diseases Service, Professor of Medicine, University of California, San Diego. Article: Pseudomonas aeruginosa ventricular assist device infections: findings from ineffective phage therapies in five cases https://journals.asm.org/doi/10.1128/aac.01728-23 Questions Answered: How are we doing with phage therapy at this point? What are the challenges to deploy phage therapy in clinical settings? The 5 cases of failure of phage therapy in patients with LVADs summarized What factors did Dr. Aslam identify that were related with the failure? How do you develop neutralization against phages and how can you prevent it?   Bacterial isolates with varying phage susceptibility, how can this be detected? What did Dr. Aslam learn? Future research This episode is brought to you by the Antimicrobial Agents and Chemotherapy journal available at aac.asm.org. If you plan to publish in AAC, ASM Members get up to 50% off publishing fees. Visit asm.org/membership to sign up. Visit journals.asm.org/journal/aac to browse issues and/or submit a manuscript.

In this episode of the Micro Binfie Podcast, hosts Dr. Andrew Page and Dr. Lee Katz delve into the fascinating world of hash databases and their application in cgMLST (core genome Multilocus Sequence Typing) for microbial bioinformatics. The discussion begins with the challenges faced by bioinformaticians due to siloed MLST databases across the globe, which hinder synchronization and effective genomic surveillance. To address these issues, the concept of using hash databases for allele identification is introduced. Hashing allows for the creation of unique identifiers for genetic sequences, enabling easier database synchronization without the need for extensive system support or resources. Dr. Katz explains the principle of hashing and its application in genomics, where even a single nucleotide polymorphism (SNP) can result in a different hash, making it a perfect solution for distinguishing alleles. Various hashing algorithms, such as MD5 and SHA-256, are discussed, along with their advantages and potential risks of hash collisions. Despite these risks, the use of more complex hashes has been shown to significantly reduce the probability of such collisions. The episode also explores practical aspects of implementing hash databases in bioinformatics software, highlighting the need for exact matching algorithms due to the nature of hashing. Existing tools like eToKi and upcoming software are mentioned as examples of applications that can utilize hash databases. Furthermore, the conversation touches on the concept of sequence types in cgMLST and the challenges associated with naming and standardizing them in a decentralized database system. Alternatives like allele codes are mentioned, which could potentially simplify the representation of sequence types. Finally, the potential for adopting this hashing approach within larger bioinformatics organizations like Phage or GMI is discussed, with an emphasis on the need for a standardized and community-supported framework to ensure the longevity and effectiveness of hash databases in microbial genomics. This episode provides a comprehensive overview of how hash databases can revolutionize microbial genomics by solving long-standing issues of database synchronization and allele identification, paving the way for more efficient and collaborative genomic surveillance worldwide.

TWiV discusses effectiveness of this season's flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Effectiveness of flu vaccine (MMWR, Eurosurveill) Efficacy of Pfizer RSV vaccine (Pfizer) Understanding six types of vaccine technologies (Pfizer) nOPV in US? (CDC) Dengue in Peru (Peruvian State) Measles in Michigan and Indiana Marburg virus control by reservoir bats (Nat Commun) tRNA acquisition by phages (Cell) Viruses of Microbes 2024 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The reappearance of Lake Manly Kathy – “Practical Playbook for Addressing Health Misinformation” Rich – Making It So: A Memoir by Patrick Stewart Jolene – Thinking Like a Phage by Merry Youle Vincent – The Science of Leap Year Listener Picks Blog design – Anthony Fauci will reflect on his long government career in ‘On Call,' to be published in June Peter – Republican warns of vaccines being slipped into vegetables: ‘A polio vaccine in there' Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Today on the Ether we have Kuji Kast hosting Phage Against the Machine in the Kuji Basement. You'll hear from El Govenor, KP, Cosmos Joe, Daniel Lux, Phunky, and more! Recorded on February 22nd 2024. Make sure to check out the newest tracks from Finn and the RAC FM gang over at ImaginetheSmell.org! The majority of the music at the end of these spaces can be found streaming over on Spotify, and the rest of the streaming platforms. Thank you to everyone in the community who supports TerraSpaces.

Today, Dr. Danielle Campbell (and former #DocMartian!), a postdoctoral scholar of the Baldridge group at Washington University in St. Louis, will share her research into the relationship between bacteriophage and the gut microbiome…as well as chat about her path in science. Host: Mark O. Martin Guest: Danielle Campbell Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode Here is a link to a wonderful review article by Dr. Campbell describing the role that the microbiome can have on viral infections. Here is a link to a a publication describing the Salyersviridae, as described by Dr. Campbell. I wrote an essay about Abigail Salyers here. Here and here can be found more biographical information about Dr. Salyer's contribution to microbiology, and the remarkable life she led. A description of the career changing Microbial Diversity Course at the Marine Biological Laboratory in Woods Hole, Massachusetts.   A link to the Baldrige Laboratory at Washington University of St. Louis, where Dr. Campbell is a postdoctoral scholar. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

I had a profound and heart-wrenching conversation with renowned infectious disease specialist Steffanie Strathdee. Steffanie is Canadian-born and named by Time Magazine as one of the 50 most influential people in healthcare.  She has written a book titled The Perfect Predator.  A Scientists race to save her Husband from a Deadly Superbug. Steffanie's story unfolds like a gripping thriller. On holiday in Egypt, with her husband Tom, a deadly Superbug hijacks his body and it has Superpowers. It steals genes from other bacteria and the environment to resist antibiotics.  This Superbug isn't an anamoloy. 5 million people will die from these types of infections in 2024. By 2050, that number is predicted to be 10 million. Why? The misuse and overuse of antibiotics in medicine and animal husbandry. Tom is airlifted to Germany, where the doctors aren't only perplexed, they are terrified as in the past this Superbog has shut down entire hospitals. They can do nothing, so Tom is Medevaced to the US.  Fighting for his life, his organs shutting down, Tom is running out of time. Steffanie is desperate.  She sees a psyche, hears about a century-old forgotten cure developed by a French Canadian but must enlist a dream team to try to save his life. What they uncover might save millions of lives, including yours and mine. To buy Steffanie and Tom's Book: The Perfect Predator. A Scientist's Race to Save Her Husband from a Deadly Superbug. https://www.amazon.com/Perfect-Predator-Scientists-Husband-Superbug/dp/0316418080 Time Code: 00:00 I introduce Stephanie Strathdee, An influential Scientist in infectious diseases. 04:48 Super Bugs are a Global Issue - 5 million deaths 05:57 Why aren't antibiotics working the way they used to?  07:54 Global agencies urge action and lack accountability measures. 10:41 The Perfect Vacation turns on a dime - A Super Bug invades Tom's body 12:40 Epidemiologist in Germany shocked by a deadly antibiotic-resistant bacterium. 15:38 Germans send Tom to the United States; nothing they can do 18:02 Tom is dying; a squeeze from his hand changes everything 24:57 Phage could be the cure but against all odds 29:48 Phage preparation to remove toxic bacteria so treatment doesn't kill Tom 30:52 Steffanie must make a life-and-death decision 34:07 Tom treasures life and moments together; phage therapy is a last attempt. 36:18  Phage saved Tom; can it save you and me? 37:48 Was this a miracle? 39:51 Tony's Three Takeaways 41:51 Tony's holiday message to you 43:50 Tony's Holiday Message   

6. Februar 1995: Kaum hat Neelix die Pforten seiner Kombüse eröffnet, tappt er auf der Suche nach dringend benötigtem Dilithium in die Falle einer bemerkenswerten Spezies des Delta-Quadranten, die Horror und Tragik miteinander vereint: die organklauenden Vidiianer. Während der Talaxianer um Atem und sein Leben ringt, ringen Simon & Sebastian erstmalig mit einer typischen "Janeway-Entscheidung". In Deutschland: Transplantationen, auf VHS am 1. Februar 1996, ausgestrahlt am 12. Juli 1996.

On this all-bacteriophage episode, TWiV explains the ‘vampire phage', and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Gerd Sutter passes (LMU) Avian influenza A (H5N1) Cambodia (WHO) CWD expands in Montana (CIDRAP) National Wastewater Surveillance System (CDC) Vampire phage paper (ISME J) UMBC phage hunters (UBMC) Vampire viruses prey on other viruses (Conversation) Phage internalized by mammalian cells (PLoS Biol) Phage uptake by mammalian cells (iScience) Phage-mammalian cell interactions (Ann Rev Virol) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Biden skips climate summit (NY Times) Rich – Lilium electric VTOL jet Alan – The Far Land, by Brandon Presser Jolene – Bacteriophage T4 infection watercolor painting by David Goodsell Vincent – Using narratives and storytelling to communicate science with nonexpert audiences Listener Picks Darach – It depends t-shirt Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Today Dr. Steffanie Strathdee, Associate Dean of Global Health Sciences at UC San Diego and Co-Director at the Center for Innovative Phage Applications and Therapeutics, will chat with us about how bacteriophages—viruses that attack bacteria—changed her life and are becoming part of our future. Host: Mark O. Martin Guest: Steffanie Strathdee Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A fun video about bacteriophages. A pretty solid overview about bacteriophages. An article about the history of bacteriophages. An article about a truly prophetic  book—“Arrowsmith”--- from 1925, by Sinclair Lewis, about using bacteriophages to fight disease. A wonderful TED talk about the rise of antibiotic resistant pathogens by Maryn McKenna. A nice overview of ESKAPE pathogens and antimicrobial resistance.  A link to a recent talk given by Dr. Strathdee. A link to Dr. Strathdee's recent book, “The Perfect Predator.” A super recent and quite wonderful review article about phage therapy by Dr. Strathdee. The SEAPHAGES program (which I always wanted to be part of!!) Ry Young's laboratory website. Dr. Strathdee's faculty website. Dr. Strathdee's Wikipedia page! A link to the website of the Center for Innovative Phage Applications and Therapeutics (IPATH).   Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

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Science Journalist Tom Ireland joins to discuss "The Good Virus: The Amazing Story and Forgotten Promise of the Phage." Don't miss this story about the virus that heals. (1:15) Then, in a rare interview about fiction, Cool Science Radio talks with debut novelist Isa Arsén about her book "Shoot the Moon," a historical fiction novel about mid-century women in science. (27:24)

Bacteria and viruses are very different, but what about when they interact? Phage biocontrols are viruses that attack specific bacteria in an organism. Dr Heather Hendrikson talks to Jesse about trialling sustainable biocontrol's for food industry.

Nels and Vincent take apart an amazing symbiosis consisting of two bacteria, one bacteriophage, and seven different genomes all within a single-celled alga. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode •Join the MicrobeTV Discord server •A single crowded cryptomonad cell (Curr Biol) •Letters read on TWiEVO 94 Science Picks Nels – What happened at NIH during the last government shutdown Vincent – Geneticist J. Craig Venter: ‘I consider retirement tantamount to death' Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

On this week's Tech Nation, Moira speaks withTom Ireland, Science Journalist and Author, “The Good Virus: The Amazing Story and Forgotten Promise of the Phage”. Then Dr. Robert Ladner, CEO & Founder of CV6 Therapeutics, tells us about their work to improve a cornerstone cancer chemotherapy.

I hope the blanks don't blank us for saying we want to depict blank getting blanked in the blank on a t-shirt. Intro Music: Grim Reaper- See You In Hell Submit music to demolistenpodcast@gmail.com. Become a patron at https://www.patreon.com/demolistenpodcast. Leave us a message at (260)222-8341 Queue: Messiahnide, Perp Walk, Apex Predator, Dungeon Keeper, Eagles Empire, Ransu's Revenge, Phage, The Holy Nothing, Stutter, Purple Pills https://messiahnide.bandcamp.com/album/problematic-for-the-people https://perpwalkswc.bandcamp.com/ https://apexpredatorhc.bandcamp.com/ https://dungeonkeeper.bandcamp.com/album/fortress-of-evil https://eaglesempire.bandcamp.com/album/into-the-vortex-of-blood-promo-tape-2023 https://ransusrevenge.bandcamp.com/album/ransus-revenge-demo https://phageofficial.bandcamp.com/  

KSQD 5-10-2023: New recommendation suggest starting mammograms for breast cancer screening at age 40 -- statin use also discussed; Superbugs found in L.A. wastewater -- explanation of the spread of antibiotic resistance; Evidence that Bronze-age people used mind-altering substances such as atropine and scopolamine; A transgender woman has a story about not being able to get a PSA test; Do stem cells from Wharton's jelly injected into your spine really work for pain? More about statin use in elders; Phage treatment as an antibacterial agent and can be used to identify a bacterial species; Your microbiome can reveal what diet you are on and how they affect hormones

Season 18, Episode 7: Brew Session (Yargle and Multani) What if they printed a creature with LITERAL DEATHTOUCH FOR PLAYERS? No, I'm not talking about that pesky Ragavan, Nimble Pilferer. Not talking about Phage, the Untouchable either. No, I'm talking about everyone's favorite Frog Spirit. Yargle and Multani is a foolish card. An insipid card. A team-up no one asked for that earned, at best, a mirthless chuckle during previews. And yet… it has 18 power. Is 18 power the same as literal deathtouch for players? Not quite, but it's tantalizingly close. Cavedan has Frog Stew on the brain, and the craving won't go away until he does his darnedest to convert Yargle's 18 power into damage applied directly to the face. He's been rummaging around in the bulk bins pulling out every copy of Cragganwick Cremator, Morgue Burst, Voldaren Thrillseeker, and Manifold Key he can find, with a little help from Goryo's Vengeance and Shadowspear. For a card with no text, Yargle and Multani allows a surprising number of Modern brews. Meanwhile, Lawson Zandi has been on an insane quest of his own. Lawson is a full hundred matches deep with Windbrisk Heights brews in Modern, and while he has yet to post any 5-0s, he's been winning at a steady 67% clip. Can he crack the code on Hideaway and finally snag that trophy? More importantly, can he save Cavedan from himself before all his tickets are incinerated on terrible Frog brews?   Like our content? Support us on Patreon and join our brewing community!   Decklists for this episode can be viewed at FaithlessBrewing.com   Timestamps [3:05] Brewing with Windbrisk Heights [21:06] Bad Ideas: Yargle and Multani Combos [27:34] Rakdos Cragganwick Kitchen [32:56] Gruul Yargle's Kitchen [37:50] Gruul Cragganwick Evolution [44:57] Final thoughts [47:27] Postscript: In the Heights

Season 18, Episode 7: Brew Session (Yargle and Multani) What if they printed a creature with LITERAL DEATHTOUCH FOR PLAYERS? No, I'm not talking about that pesky Ragavan, Nimble Pilferer. Not talking about Phage, the Untouchable either. No, I'm talking about everyone's favorite Frog Spirit. Yargle and Multani is a foolish card. An insipid card. A team-up no one asked for that earned, at best, a mirthless chuckle during previews. And yet… it has 18 power. Is 18 power the same as literal deathtouch for players? Not quite, but it's tantalizingly close. Cavedan has Frog Stew on the brain, and the craving won't go away until he does his darnedest to convert Yargle's 18 power into damage applied directly to the face. He's been rummaging around in the bulk bins pulling out every copy of Cragganwick Cremator, Morgue Burst, Voldaren Thrillseeker, and Manifold Key he can find, with a little help from Goryo's Vengeance and Shadowspear. For a card with no text, Yargle and Multani allows a surprising number of Modern brews. Meanwhile, Lawson Zandi has been on an insane quest of his own. Lawson is a full hundred matches deep with Windbrisk Heights brews in Modern, and while he has yet to post any 5-0s, he's been winning at a steady 67% clip. Can he crack the code on Hideaway and finally snag that trophy? More importantly, can he save Cavedan from himself before all his tickets are incinerated on terrible Frog brews?   Like our content? Support us on Patreon and join our brewing community!   Decklists for this episode can be viewed at FaithlessBrewing.com   Timestamps [3:05] Brewing with Windbrisk Heights [21:06] Bad Ideas: Yargle and Multani Combos [27:34] Rakdos Cragganwick Kitchen [32:56] Gruul Yargle's Kitchen [37:50] Gruul Cragganwick Evolution [44:57] Final thoughts [47:27] Postscript: In the Heights

In this episode of the It's A Mimic! podcast, the panel of Dungeon Masters sits down and looks at a truly horrifying species bred from pure chaos: the Slaadi.  With deep links to the Plane of Limbo and a rich history from previous editions, these Aberrations can and will leave a disgusting surprise for an unsuspecting character long after the fact.  Cold Open 0:00 Opening Theme 2:57 Intro 3:19 Ad Break 9:12 Lore 10:35 Tadpole 50:48 Red Slaad 1:01:19 Blue Slaad 1:23:51 Ad Break 1:45:27 Outro 1:45:56 Closing Theme 1:48:16 Bloopers 1:48:42 DON'T FORGET TO LIKE & SUBSCRIBE! Find Us On: Patreon at https://www.patreon.com/user?u=84724626 Website at https://www.itsamimic.com iTunes at https://itunes.apple.com/ca/podcast/its-a-mimic/id1450770037 Spotify at https://open.spotify.com/show/3Y19VxSxLKyfg0gY0yUeU1 Podbean at https://itsamimic.podbean.com/  YouTube at https://www.youtube.com/channel/UCzQmvEufzxPHWrFSZbB8uuw Social: Facebook at https://www.facebook.com/itsamimic/ Instagram at https://www.instagram.com/itsamimic/?hl=en Reddit at https://www.reddit.com/r/ItsaMimic/ Email at info@itsamimic.com Dungeon Master 1:  Adam Nason Dungeon Master 2:  Kyle McQuaid Dungeon Master 3:  Megan Lengle Narrator:  Pepperina Sparklegem Written by:  Adam Nason Director:  Adam Nason Editor:  Adam Nason Executive Producer:  Adam Nason Intro/Outro Music by:  Cory Wiebe All other music provided by Tyler Gibson at https://www.instagram.com/melodicasmusic Logo by:  Katie Skidmore at https://www.instagram.com/clementineartportraits/ This episode is meant to be used as an inspirational supplement for Dungeons & Dragons 5th Edition and tabletop roleplaying games in general.  It's A Mimic! does not own the rights to any Wizards of the Coasts products. Artwork included in this episode's video visualizations is published and/or owned by Wizards of the Coast.

TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses. Links for this episode: Phage therapy against M. abscessus lung infection (Cell) Encapsulation of the septal cell wall protects S. pneumoniae from host defenses (PLoS Path) Letters read on TWiM 279

Before Covid, the bacterial infection "tuberculosis" was the number 1 infectious disease killer on the planet. Every day it claims the lives of thousands, with the impact particularly marked in lower income countries which account for 80% of the cases. But that doesn't mean that richer countries are off the hook. As people migrate, and wars displace refugees, Western countries are seeing a rising trend in new TB cases, particularly of highly drug-resistant forms of the infection. So this week we're looking at new ways to combat one of the oldest and most fearsome infections on the planet... Like this podcast? Please help us by supporting the Naked Scientists

TWiM explains the discovery of hotspots of genetic variation containing reservoirs of anti-phage systems in E. coli phages and their parasitic satellites, and pathogen desiccation tolerance promoted by hydrophilins. Become a patron of TWiM. Links for this episode Phage and satellite antiviral systems (Cell Host Micro) Hydropilins promote desiccation tolerance (Cell Host Micro) Letters read on TWiM 265 TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

Neelix goes along for an away mission to find dilithium but comes back with neither the crystals nor his lungs! Janeway must track down the aliens who are responsible while Neelix is kept alive by a risky medical procedure. Take a breath, then explore Phage with Mission Log. Sponsored by -

AOD Fire- I'm back, I'm back, don't make it weird. Special announcement from the Gal Fed Music By Mark Pontius