Podcasts about s2215

Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners.   In this episode, we begin to explore the neurobiology of the serotonin system — along with key pharmacological agents (SSRIs and classical psychedelics) that act on this system — with guest expert Dr. Robin Carhart-Harris, a neuroscientist and head of the Centre for Psychedelic Research at Imperial College London.   Our discussion is more theoretical than directly clinically relevant, striving to provide a mechanistic understanding of how serotonin functions within the brain and how serotonin-modulating drugs influence this system. The episode was inspired by a review published by our guest expert and Dr. David Nutt called “Serotonin and brain function: a tale of two receptors” (cited below). If you are interested in the topic, you might consider reading this review in full! Please note that the figures referenced during this episode can be accessed at https://journals.sagepub.com/doi/figure/10.1177/0269881117725915.   The learning objectives for this episode are as follows:    By the end of this episode, you should be able to…   Understand the general anatomy and function of the serotonin system, with a focus on the purported activity of the more common serotonin receptors and transporters. Describe the effects of serotonin reuptake inhibitors and how they lead to symptom improvement in mood and anxiety disorders, in addition to the mechanism of action of other serotonergic medications. Consider the two-pronged serotonin system conceptualized by Dr. Carhart-Harris, and understand how serotonergic agents (including SSRIs and classic psychedelics) and the concepts of active and passive coping fit within this theory.   Guest: Dr. Robin Carhart-Harris, a neuroscientist and head of the Centre for Psychedelic Research at Imperial College London.   Produced and hosted by: Dr. Chase Thompson (PGY3), Dr. Lucy Chen (Psychiatrist), Dr. Nikhita Singhal (PGY2)   Audio editing by: Dr. Chase Thompson   Infographic by: Dr Chase Thompson, Dr Nikhita Singhal   Interview Content:   00:18 - Introductions 3:00 - Learning objectives 4:10 - Introduction to serotonin 10:30 - 5HT1A receptors 24:30 - 5HT2A receptors 30:20 - Serotonin system operation under normal conditions 35:00 - Introduction of bipartite model / two divergent methods for addressing depression 42:20 - Parallels between psychological destabilization (through therapy) and the psychedelic effect  46:20 - Who should not have a psychedelic experience? Are psychedelics intrinsically psychotherapeutic or facilitative in nature? 50:20 - Brief discussion of the neuroimaging correlates of psychotherapeutic benefits from psychedelic experiences 58:40 - Discussion of why 2A agonists cause psychedelic effects but high serotonin release does not   Resources:   Carhart-Harris RL, Nutt DJ. Serotonin and brain function: a tale of two receptors. J Psychopharmacol. 2017;31(9):1091-1120. https://doi.org/10.1177/0269881117725915 Artigas F, Nutt DJ, Shelton R. Mechanism of action of antidepressants. Psychopharmacol Bull. 2002;36 Suppl 2:123-132. Antidepressants. In: Stahl SM. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. 4th ed. Cambridge University Press; 2013:284-369. Beliveau V, Ganz M, Feng L, et al. A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System. J Neurosci. 2017;37(1):120-128. https://doi.org/10.1523/JNEUROSCI.2830-16.2016 Carhart-Harris RL, Bolstridge M, Rucker J, et al. Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry. 2016;3(7):619-627. https://doi.org/10.1016/S2215-0366(16)30065-7 Carhart-Harris RL, Leech R, Hellyer PJ, et al. The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Front Hum Neurosci. 2014;8:20. https://doi.org/10.3389/fnhum.2014.00020 Carhart-Harris RL, Friston KJ. REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. Pharmacol Rev. 2019;71(3):316-344. https://doi.org/10.1124/pr.118.017160 Griffiths RR, Johnson MW, Carducci MA, et al. Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. J Psychopharmacol. 2016;30(12):1181-1197. https://doi.org/10.1177/0269881116675513 Griffiths RR, Richards WA, McCann U, Jesse R. Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology (Berl). 2006;187(3):268-292. https://doi.org/10.1007/s00213-006-0457-5   CPA Note: The views expressed in this podcast do not necessarily reflect those of the Canadian Psychiatric Association. For more PsychEd, follow us on Twitter (@psychedpodcast), Facebook (PsychEd Podcast), and Instagram (@psyched.podcast). You can provide feedback by email at psychedpodcast@gmail.com. For more information, visit our website at psychedpodcast.org.

Aaron Kandola, Gemma Lewis, David P J Osborn, Brendon Stubbs, Joseph F Hayes, Depressive symptoms and objectively measured physical activity and sedentary behaviour throughout adolescence: a prospective cohort study, The Lancet Psychiatry, 2020 https://doi.org/10.1016/S2215-0366(20)30034-1 Find John on social media: Instagram - @drjohncampione Check out www.knackbags.com whenever you buy a bag just use our affiliate code ROCKCAST. It won’t cost you anything extra and shipping on all bags is free. Trust me when I tell you, you are going to love your Knack bag. Don’t forget 15% off your next order of tape, topicals, mobility tools and apparel at shop.rocktape.com. 15% off of the best tape and gear around! Use Promo code: ROCKCAST

Hello my fellow Hemp nuts! Are you ready for the cannabis bonanza?! Welcome to the New Hemp Times show recorded at Gotham Studio, the sweetest smelling podcast studio in the world. Today’s episode is partially powered by McSorley’s Chilli Dogs, McSorley Ale house, the oldest ale house in the United States. Also, powered by Five and Dimes Old Fashioned, hand crafted by Erin.We have a fun show for you today!Segments:Our word of the day is tinctures.Research: Lancet article on Psychosis and cannabis.We will test your knowledge of recent cannabis news and science.And time permitting we will provide a Q&A about PTSD and cannabis and other issues in the hemp and cannabis space.We are joined by Jan Roberts, our resident clinician and LCSW, CEO of the IRCCMH.Also participating today is the Unapologetic Farmer, Randy Cameroon, Jr. CEO of Brooklyn Sprouts Social Enterprises, engaging in one of the most radical things you can do, grow your own food and medicine in an urban environment. Working with Interfaith medical center And from HBO’s crashing, performing every week in Manhattan, living the dream, Greer Barnes!And, of course Dr. J (aka Jahan Marcu,Ph.D)Word of the day: Tincture - Notes below:What is a tincture you may ask? Tinctures are liquid extracts made from herbs that you take orally (by mouth). They are usually extracted in alcohol (known here on our website as "regular"), but they can also be extracted in vegetable glycerine or apple cider vinegar (non-alcohol). Tinctures are easy and convenient to use. Tinctures are also easier to give to children as they have to take only small amounts (see Children's Dosage Guide for suggestions). Because they are taken directly under the tongue, they enter the bloodstream much more quickly and directly than by any other means. This means that the action in the body is usually quicker. Although some herbs will have an immediate effect, such as those used to help one relax, others that are more nutritive and building in nature may take several weeks of continual use before best results are seen (much like a multi-vitamin).In the 19th century, the Irish surgeon O’Shaughnessy reintroduced the use of cannabis from India into Western medicine. Cannabis sativa L. (Cannabaceae)—largely in the form of ethanolic tinctures—was then part of main Western pharmacopoeias until the 1930s, when it was removed gradually with increasing recreational use and its legal prosecution In the second half of the 19th century, over 100 scientific articles were published in Europe and the United States about the therapeutic value of cannabis.13 The climax of the medical use of cannabis by Western medicine occurred in the late 19th and early 20th century. Various laboratories marketed cannabis extracts or tinctures, such as Merck (Germany), Burroughs-Wellcome (England), Bristol-Meyers Squibb (United States), Parke-Davis (United States), and Eli Lilly (United States).As non-alcohol tinctures have no alcohol content to them to act as a preservative, they can easily become contaminated and are at risk for growing mold. Alcohol, pregnancy and drug interactions: One dose of an alcohol-based tincture has approximately the same alcohol content as eating a very ripe bananaSativex is licensed in about 30 countries, an insane about of gold standard clinical research is published about this product, which is essentially a tincture with a spray nozzle. LANCET ARTICLE, additional articles:https://www.thelancet.com/action/showPdf?pii=S2215-0366%2819%2930048-3https://nypost.com/2019/03/20/daily-marijuana-use-linked-with-higher-risk-of-psychosis-study/https://www.npr.org/sections/health-shots/2019/03/19/704948217/daily-marijuana-use-and-highly-potent-weed-linked-to-psychosishttps://www.rollingstone.com/culture/culture-news/marijuana-psychosis-lancet-study-810568/https://thehill.com/opinion/healthcare/435448-will-smoking-cannabis-make-you-psychotic-not-likelyTools for Understanding Lancet data:Odds ratioOR=1 Exposure does not affect odds of outcomeOR>1 Exposure associated with higher odds of outcome OR