Podcasts about ssris

If you're on antidepressants and your sex drive has completely disappeared, I want you to know that you're not broken, and you don't have to choose between feeling mentally well and having a fulfilling sex life. SSRIs like Lexapro, Zoloft, and Prozac are genuinely life-changing for so many people, but nobody warns you that they can tank your desire, make orgasms nearly impossible, and quietly wreck your relationship in the process. In this episode, I'm breaking down exactly why this happens, and more importantly, what you can actually do about it. From simple timing hacks to alternative treatments that are showing real promise. In this episode, you'll learn: • Why SSRIs suppress desire and arousal on a hormonal level — and the one hack that can reduce side effects as soon as tonight • How to rebuild your sex drive when both you and your partner are medicated (yes, this is more common than you think) • The alternative treatments — TMS therapy, ketamine, and psilocybin — that are helping people get off antidepressants entirely More Dr. Emily:  • Shop With Emily! Explore Emily's favorite toys, pleasure accessories, bedroom essentials, and more — designed to support your pleasure and confidence. Free shipping on orders $99+ (some exclusions apply). • Join the SmartSX Membership: Access exclusive sex coaching, live expert sessions, community building, and tools to enhance your pleasure and relationships with Dr. Emily Morse. • Interested in 1:1 Coaching with Emily? Go to sexwithemily.com/coaching to apply!  • Sex With Emily Guides: Explore pleasure, deepen connections, and enhance intimacy using these Sex With Emily downloadable guides. • The only sex book you'll ever need: Smart Sex: How to Boost Your Sex IQ and Own Your Pleasure • Want more? Visit the Sex With Emily Website • Let's get social: Instagram | X | Facebook | TikTok | Threads | YouTube • Let's text: Sign up here • Want me to slide into your email inbox? Sign Up Here for sex tips on the regular. Chapters: 0:00 - Intro 0:31 - Sarah's Story: The SSRI Sex Drive Dilemma 3:50 - Why SSRIs Kill Your Libido (The Science) 6:50 - How Common Is This? Depression & Sex Stats 14:00 - Side Effects Breakdown: Vulva vs. Penis Owners 15:50 - Practical Hacks: Timing, Alcohol & Cannabis 20:53 - Alternative Treatments: TMS, Ketamine & Psychedelics 25:31 - Both Partners on SSRIs? How to Rebuild Intimacy 31:58 - The 36 Questions Study That Reignites Closeness 33:37 - Perimenopause, Hormones & Anti-Depressants at 48 Learn more about your ad choices. Visit megaphone.fm/adchoices

Hot flashes. Brain fog. Sleepless nights. For too long, we've mislabeled midlife women's health as burnout, anxiety, or a loss of ambition. But what if the real issue isn't performance — it's hormones? In this episode of Hello Monday, Jessi Hempel talks with Joanna Strober, founder and CEO of Midi Health, about menopause, perimenopause, hormone therapy, and power at work. Together, they unpack how gaps in women's healthcare during midlife are quietly pushing talented leaders out of the workforce at the exact moment they should be accelerating. After struggling to get proper treatment for her own perimenopause symptoms, Joanna built Midi Health to deliver insurance-covered, expert virtual care focused on women in midlife. This conversation goes beyond hot flashes — it's about workplace equity, hormone replacement therapy (HRT), ageism, health misdiagnoses, and why normalizing menopause could unlock a generation of leadership. Because menopause isn't a road bump, with the right care, it can be a power surge. Jessi and Joanna discuss: The difference between perimenopause and menopause, and why the distinction matters for women's health at work Why 1 in 5 women in their 40s are prescribed SSRIs — and how hormonal shifts are often overlooked Hormone replacement therapy (HRT) and non-hormonal menopause treatments The workplace impact of untreated menopause symptoms, including research showing women may lose authority during visible symptoms like hot flashes How employers can support midlife women through better insurance coverage  Ageism in the workplace — and why women in their 50s may be primed for peak performance How normalizing menopause conversations can help women reclaim power Follow Joanna Strober and Jessi Hempel on LinkedIn. We will be launching the Hello Monday book club soon. If you're interested in joining, send us an email at hellomonday@linkedin.com and let us know!  Watch on YouTube: https://bit.ly/hellomonday-LI-video-youtube  Watch/Listen on Spotify: https://bit.ly/hellomonday-LI-video-spotify⁠ Listen on Apple: https://bit.ly/hellomonday-LI-video-apple⁠ 

Can something as simple as walking or running rival antidepressants? In this episode of The Lebanese Physicians Podcast, I sit down with Dr. Farid Talih, American board–certified psychiatrist, sleep medicine and addiction specialist, to explore the powerful science behind exercise as a treatment for depression and anxiety. We dive into: How exercise reshapes the brain through BDNF (brain-derived neurotrophic factor) Why movement works differently than SSRIs and psychotherapy The role of lactate, cortisol, endorphins, and the “runner's high” Exercise vs medication: when to use one, the other, or both Group exercise, loneliness, and mental health Practical, realistic ways to “prescribe” movement in real-world settings Cultural, socioeconomic, and access barriers to exercise Exercise in pregnancy, postpartum depression, aging, and addiction recovery Why mental health care must stay individualized, humane, and holistic This episode challenges the idea that mental health treatment is only about prescriptions and reminds us that movement, connection, and context matter.

Send a textEver been told “antidepressants change your personality” or “you'll be on them forever”? We're cutting through the noise with a clear, grounded tour of how modern antidepressants work, why they were discovered by accident, and what real people should know before starting, switching, or stopping. We share the surprising roots of MAOIs and tricyclics, how SSRIs became mainstream, and where ECT fits today for treatment-resistant cases. No jargon, no scare tactics—just the essentials you can use to make smarter choices with your clinician.We break down brain basics in plain English: neurons, synapses, and the roles of serotonin, norepinephrine, and dopamine in mood and motivation. You'll hear why reuptake inhibition matters, what changes to expect first, and how to spot common side effects like sleep shifts, nausea, and sexual dysfunction. Just as important, we draw a bright line between dependence and addiction, and explain why tapering off—never quitting cold turkey—protects your body while you pivot your plan.Along the way, we talk stigma, ask the questions your provider hopes you'll bring, and explore how medication pairs with therapy, sleep, movement, and community to create lasting relief. Plus, a gripping “Winner of the Week” rescue, show updates from the Motor City Hypnotist studio, and a quick adoption spotlight for Minnie from Detroit Dog Rescue. If you've been curious, cautious, or confused about antidepressants, this conversation gives you the clarity to move forward with confidence.If this helped, follow the show, share it with a friend who needs straight answers, and leave a review so more listeners can find us. Got a question we didn't answer? Send it our way and we'll tackle it next.FIND ME:My Website: https://motorcityhypnotist.com/podcastMy social media links: Facebook: https://www.facebook.com/motorcityhypnotist/YouTube: https://www.youtube.com/channel/UCCjjLNcNvSYzfeX0uHqe3gATwitter: https://twitter.com/motorcityhypnoInstagram: motorcityhypnoFREE HYPNOSIS GUIDEhttps://detroithypnotist.convertri.com/podcast-free-hypnosis-guidePlease also subscribe to the show and leave a review.(Stay with me as later in the podcast, I'll be giving away a free gift to all listeners!)Change your thinking, change your life!Laugh hard, run fast, be kind. David R. Wright MA, LPC, CHTThe Motor City Hypnotist

Something dark is happening in America and almost no one is connecting the dots. From the rise of mass shootings to the explosion of antidepressant use, I break down what RFK Jr is uncovering about SSRIs, cultural confusion, and a spiritual fog settling over the West  . We also expose the media spin around trans violence, Europe's identity crisis, and why leaders like Marco Rubio are calling the West back to strength before it is too late.   Podcast Episode 2035: Explosive Study Links Mass Shootings to the Drug Industry Doping 20% of America | don't miss this! Listen to more episodes of the Lance Wallnau Show at lancewallnau.com/podcast

Join Lionel on The Other Side of Midnight as he delves into the "seamy dark underbelly" of reality to find the dust bunnies the mainstream media ignores. In this episode, Lionel dissects the "conspiratorium" code, challenges the official narrative on Kurt Cobain's death, and questions the link between SSRIs and violent crime. From the "Kayfabe" of the justice system to the shadowy SES deep state, Lionel asks the question: "Why aren't they talking about this?" Learn more about your ad choices. Visit megaphone.fm/adchoices

Keegan Downer (Founder of mindfulMEDS) shares how he went from alcohol addiction and a near-suicidal breaking point, to recovery and to building one of Canada's most recognized microdosing education brands, and why psilocybin doesn't have to be "woo."  We also get super practical: What microdosing actually feels like day-to-day, why it can hit women differently (especially moms), how psilocybin compares to SSRIs (Selective Serotonin Reuptake Inhibitor) when it comes to emotional processing, and why "wine o'clock" culture is quietly keeping so many women stuck in a stress-and-numb cycle. Join my NEW private community at thelongherlife.com for ongoing protocols, live coaching, and deeper support. WE TALK ABOUT:  05:40 - Keegan's life collapse that led to addiction and the "rooftop moment"  07:45 - Rebuilding purpose after rehab and the anxiety attack that changed everything  09:10 - Why microdosing went from "nobody's talking about this" to mainstream fast  12:35 - The day-13 breakthrough and the microdosing study that launched his mission  19:30 - Why psilocybin and SSRIs create totally different emotional outcomes  23:20 - When microdosing feels "too strong" and how dose + setting change everything  28:40 - The dose reality check: "microdose" vs "creative dose" and why sensitivity matters  38:20 - Why women (especially moms) are the fastest-growing microdosing segment  41:05 - "Wine o'clock" culture, addiction masking, and the uncomfortable truth  44:00 - Brainbow: The saffron extract approach for mood, sleep, and nervous system support  57:10 - Where to learn more, the free microdosing guide, and weekly consults RESOURCES: Join my NEW private community at thelongherlife.com for ongoing protocols, live coaching, and deeper support. Join me in Costa Rica for Optimize Her, a 5-night luxury women's retreat with biohacking, yoga, healing rituals, and longevity workshops—only 2 spots left. Download the non-toxic baby registry guide to reduce toxic exposure and make confident, evidence-informed choices for your family—free. Mindful Meds website and Instagram Get The Mindful Meds Microdosing Guide here LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music  

In this conversation, the hosts ions, andeen dietary choices and ketosis levels, and clarify the differences between ketosis and ketoacidosis. The conversation also touches on insulin resistance, explaining it as a protective mechanism rather than a failure of insulin itself, and critiques the pharmaceutical approaches to managing these metabolic issues. In this conversation, the speakers delve into the dangers of SSRIs, the misconceptions surrounding cholesterol, and the misleading nutritional claims often made about foods like spinach. They discuss the importance of understanding bioavailability in nutrition, particularly regarding iron and vitamin C absorption, and highlight the profit-driven motives of the pharmaceutical industry, including the practice of creating 'satellite drugs' to maximize profits.Chapters00:00 Introduction and Greetings01:01 Understanding Ketosis and Its Fluctuations04:46 The Role of Continuous Monitoring in Ketosis06:28 Exploring Ketosis Levels and Dietary Impact10:50 Misconceptions About Ketosis and Ketoacidosis14:15 Insulin Resistance Explained18:42 Pharmaceutical Interventions and Their Implications21:40 The Dangers of SSRIs and Pharmaceutical Practices22:59 Debunking Cholesterol Myths27:55 The Truth About Nutritional Claims34:01 Understanding Vitamin C and Iron Absorption39:01 The Dark Side of Pharmaceutical Profitability

Have you ever heard of inositol? Could you be deficient and not even realize it? If you're struggling with blood sugar swings, irregular cycles, anxiety, or 2am wake-ups, could this overlooked compound be a missing piece? While magnesium, B vitamins, and electrolytes dominate most wellness conversations, myo-inositol plays a critical role in insulin signaling, ovarian function, and neurotransmitter balance, acting as an intracellular messenger that helps your cells properly respond to hormonal cues. This episode unpacks what myo-inositol actually is, how it functions in the body, and what the research shows in areas like PCOS, insulin resistance, fertility, mood disorders, and sleep. It also covers therapeutic dosing, food sources, and how to use supplementation strategically for clinical outcomes. Whether you're navigating hormone imbalance, metabolic dysfunction, or nervous system dysregulation, this conversation takes a deeper look at why myo-inositol deserves far more attention in root-cause medicine. Also in this episode: What is inositol? What does it do in the body? What causes myoinositol deficiency? Symptoms of deficiency Episode 470: SSRIs on the Rise: Concerns and Safer alternatives Episode 430: Keto and PCOS Inositol and Metabolic Health Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome | New England Journal of Medicine Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial - PubMed Potential role and therapeutic interests of myo-inositol in metabolic diseases - PubMed Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials - PMC  Myoinositol vs. Metformin in Women with Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial - PMC The Comparative Effects of Myo-Inositol and Metformin Therapy on the Clinical and Biochemical Parameters of Women of Normal Weight Suffering from Polycystic Ovary Syndrome Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials - PubMed Full article: Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials Inositol for Mental Health Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder - PubMed Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder - PubMed Inositol treatment of obsessive-compulsive disorder - PubMed D-Chiro inositol vs. Myoinositol Food sources of inositol Dosage, safety and tolerability 1-2 scoops Relax and Regulate  This episode is sponsored by Naturally Nourished Relax and Regulate Relax & Regulate has always been a superstar for sleep, stress, and hormone support, and we've taken a good thing and made it even better! We've seen incredible results with 1000's of clients using Relax and Regulate literally every day for 10+ years now.    We have increased magnesium bisglycinate from 200 mg to 250 mg to match clinical sleep research dosing, kept myo-inositol at the full 4-gram therapeutic dose, and improved the supporting ingredients so the entire formula is better absorbed, better tolerated, and more aligned with what we're seeing clinically every day. Use code RELAX15 to save 15% on our reformulated Relax and Regulate! 

In the first hour of episode #1156, Clay Edwards fires up your Monday with raw motivation to rise, grind, and conquer the week. He shares his weekend highlights, including subscribing to the Angel Studios app for faith-based and conservative-leaning content, and highly recommends the must-watch documentary "Thank You, Dr. Fauci," unpacking COVID conspiracies, lab leaks, vaccine funding, and money-driven cover-ups with insights from scientists, journalists, and a former CDC head. Clay also dives into the post-apocalyptic thriller "Homestead" and its series, tying into real-world prepping discussions. A caller chimes in on methane facts and Mississippi court corruption, sparking thoughts on statewide issues. Teasing upcoming headlines like Amazon's Ring split, a Jackson restaurant brawl, education wins, and eerie Epstein Island links to SpongeBob. Plus, a fiery take on a Maryland school official reporting conservative teens to child services for starting a TPUSA club, exposing left-wing indoctrination fears. Unfiltered rants on liberal hysteria, SSRIs, and generational politics round out the hour—strap in for no-holds-barred reality radio.

In the second hour of episode #1156, Clay Edwards takes a deep dive into generational politics, exploring why Gen X has been largely sidelined in leadership roles, blaming boomers for clinging to power and delaying opportunities—now leaving many Gen Xers in their 40s and 50s too established in careers and family life to pivot. He breaks down stats on Congress (Gen X at 41% in the House but only 28% in the Senate) and Mississippi's legislature (average age 57, boomers dominant at 45%), urging Gen X to step up and counter liberal indoctrination. A caller sparks debate on holding teachers' unions accountable, pushing "feel-good" policies over core education, and infiltrating local politics. Clay unleashes unfiltered rants on liberal Gen Xers as the most offended and medicated group, SSRIs turning affluent white women "gay" (with satirical jabs at stereotypes), and the revival of racism by black Gen X post-Obama. He shares personal views on relationships, favoring driven partners over dependents, and stresses trade schools over useless college degrees. Wrapping with listener texts on anti-ICE protests, Gen X presidents, and positive solutions—pure, no-holds-barred commentary on culture, corruption, and America's soul.

Trish Wood on Canada before and after Tumbler Ridge. There is much to learn from this generational tragedy. The danger of SSRIs, the power of anti-psychotic drugs, and the folly of "trans-affirming psychotherapy" for self-diagnosing teenagers. Dangers we already know, but do nothing about. Watch and Read Trish on Substack Follow Trish on X @woodreporting Website: www.trishwoodpodcast.com 

Get original articles, extended podcasts, and direct access to Blendr News on our Substack Channel: blendrnews.com-This episode is brought to you by The Tallowed Truth. Use promo code "Blendr" for 15% off:www.thetallowedtruth.com/blendr-In this episode of "The Blendr Report," Jonathan and Liam discuss:00:00 The Tumblr Ridge Massacre: A Tragic Intersection02:33 Mental Health and Pharmaceutical Influence11:39 Cultural and Institutional Complicity20:22 The Consequences of Identity Politics27:25 Healthcare Failures and Political Accountability34:14 Uncovering Epstein's Connections-Follow BLENDR News:Twitter - @BlendrNewsInstagram - @blendr.report TikTok - @blendrnews-Follow Jonathan:Instagram - @itsjonathanharveyTikTok - @itsjonathanharvey-Follow Liam:Instagram - @liam.out.loudTwitter - @liam_out_loudYouTube - @liam-out-loud

In this episode of Prescribing Lifestyle, Camilla Thompson joins me to share her trailblazing journey from corporate burnout and mold toxicity to becoming Australia's leading biohacking coach, keynote speaker, and author of BioHackMe. Camilla breaks down biohacking as accessible, personalised, preventative health—empowering you to take control through science-backed strategies that fit real life (not just for Silicon Valley billionaires). What We Cover: Camilla's Health Journey Growing up with a "low tox" pioneer mum who was ahead of her time Living in toxic mold for years (1 in 2 Australians affected), leading to anxiety, brain fog, chronic inflammation, and misdiagnoses Reversing her biological age by 10 years through biohacking after detoxing her life Overcoming postnatal depression with Traditional Chinese Medicine (acupuncture + herbs) after SSRIs failed Biohacking Made Simple & Accessible Why biohacking = personalised health through testing, data, and intuition (not expensive gadgets) Kitchen audit: ditch ultra-processed foods, swap plastics for glass/bamboo Budget biohacks: cold showers (250% dopamine boost), morning sunlight, walking in nature Mediterranean diet for longevity: pasture-raised eggs, avocados, olive oil, quality fats Women vs. Men + Real Talk Only 3% of health research on women—we're not "little men" Perimenopause/menopause symptoms often mimic mold toxicity Architect mindset (take control) vs. victim mindset (external blame) Why caregivers (mostly women) face higher autoimmune rates Camilla's Work BioHackMe book: practical, science-simplified guide (finalist in Australian Business Book Awards) 1:1 coaching with DNA methylation/genetic testing Bali retreats at Reviver Wellness (women-only, mother-daughter): soul + science (hyperbaric, red light, breathwork, sound healing) Top Takeaways Your body can heal with the right environment—minimise toxic load without fear Foundations first: food quality > fancy tech Trust your bio-individuality—test, experiment, intuit Connect with Camilla:

In this conversation, Kelsi Sheren addresses the alarming youth mental health crisis in North America, highlighted by a tragic shooting incident involving a trans-identified shooter. She discusses the potential role of pharmaceuticals, particularly SSRIs and antipsychotics, in exacerbating mental health issues among adolescents. Sheren emphasizes the need for a critical examination of gender identity narratives and the over-medicalization of youth, calling for a societal shift towards understanding and supporting children's mental health without harmful interventions.Chapters00:00 Introduction to the Youth Mental Health Crisis00:45 The Tragic Shooting Incident03:43 The Role of Pharmaceuticals in Mental Health06:30 The Impact of Gender Identity on Youth10:47 The Dangers of Over-Medicalization12:00 The Call for Awareness and Change - - - - - - - - - - - -One Time Donation! - Paypal - https://paypal.me/brassandunityBuy me a coffee! - https://buymeacoffee.com/kelsisherenLet's connect!Youtube - https://www.youtube.com/@thekelsisherenperspectiveInstagram -  https://www.instagram.com/thekelsisherenperspective?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw%3D%3DX: https://x.com/KelsiBurnsInstagram: https://www.instagram.com/kelsie_sheren/Substack:  https://substack.com/@kelsisherenTikTok -   https://x.com/KelsiBurnsSUPPORT OUR SPONSORS - - - - - - - - - - - -MasterPeace - 10% off with code KELSI - http://www.MasterPeace.Health/KelsiKetone IQ- 30% off with code KELSI - https://ketone.com/KELSIGood Livin - 20% off with code KELSI - https://www.itsgoodlivin.com/?ref=KELSIBrass & Unity - 20% off with code UNITY  - http://brassandunity.com

If pain is a portal, what's on the other side? We invited functional pharmacist and men's health coach Rob Kress to help us challenge the default settings of modern care...more meds, more noise, less self. Rob shares how he moved from conventional pharmacy to a practice that blends functional medicine, clinical nutrition, and mind‑body work, and why the real turning point for so many men is a regulated nervous system and the courage to tell the truth.We dig into the moments most men avoid. The numbness that follows chronic stress, the swing between agitation and apathy, and the quiet stories they keep buried deep. Rob offers simple, practical resets like two minutes to breathe before a hard talk, a short burst of movement to discharge stress, and five minutes of daily silence to build safety and presence. From there, we unpack testosterone: when TRT helps, when it masks a deeper issue, and how thyroid, adrenals, sleep, alcohol, and cannabis shape libido and drive more than most realize.Our conversation gets real about America's medication reflex. SSRIs and benzos can bring relief, but they often mute feeling and complicate long‑term healing. Rob shares how to taper thoughtfully with breathwork, body‑based therapy, a good team and a plan.We also explore autism through a systems lens. Acetaminophen's impact on glutathione, the difference between folic acid and folate, the promise of folinic acid for speech in some kids, and how dairy may elevate folate receptor autoantibodies. It's not about single causes. It's about looking at every angle.We close with agency. Interview your doctors, curate a care team, and choose tools that align with your values. The path to health and healing is meant to be co‑creative. Show up for the meaningful work, focus on the what, and release the need to control the timeline. If this conversation recharged your curiosity, share it with a friend, leave a review, and subscribe. And check out our Patreon so you never miss an episode.https://www.patreon.com/c/seeyouontheothersideConnect with Rob here:www.instagram.com/robkressfrx?https://linktr.ee/robkressfrxhttps://www.functionalpharmacy.com/contact-rob Microdosify 10% OFF our trusted microdose supply!1:1 Discovery Calls Are psychedelics right for you on your healing journey? Book a discovery call to ask us anything. Support the showJoin our Patreon for exclusive content:https://www.patreon.com/seeyouontheotherside Our Website:https://linktr.ee/seeyouontheothersidepodcast

(featured photo shows David, his wife Yvonne, and son, Joey, when young) Meet the Incredible Dr. David Antonuccio, Part 2 of 2 Shrink, Songwriter, and Hero Today we continue our conversation with my dear friend and esteemed colleague, Dr. David Antonuccio, a true scholar, clinician, researcher, musician, and champion of scientific transparency. The Nicotine Patch Study David revisited his landmark research on the nicotine patch, a costly trial involving roughly 600 participants who were randomly assigned to receive either a real nicotine patch or a sham patch. The goals were to assess safety and efficacy. The safety data looked reassuring. However, the efficacy findings were unexpected: the placebo patch worked just as well as the active nicotine patch in reducing smoking. The sponsoring company published the safety data but refused to publish—and refused David access to—the efficacy findings, which showed no advantage for the nicotine patch. You can check the link to the NEJM article here.  David writes: "Notice the 48 week follow-up data were excluded in this paper despite the fact that they were available. That really annoyed me. I also now believe that the original version of the paper was ghostwritten and ghost analyzed by the industry folks.in other words.  I'm not sure that the authors ever had access to the "raw" data before they were analyzed." This was important because there was a decrease in smoking DURING the study among those wearing the patch, and getting their "fix" of nicotine that way. . . but what happened AFTER the study?  David writes: "Here is the link to the follow up paper that emphasized efficacy and included the 48 week follow-up data." Notice that this paper was not published until three years later, when the Nicotine Patch had already been heavily advertised and sold on the market. This early experience in his career revealed the tension between marketing interests which focus on sales, and scientific interests which focus on truth and transparency—a daunting and frustrating pattern that would emerge again and again in his career. Expert Testimony in a Tragic Criminal Case David then described expert testimony he provided in a deeply troubling legal case. A 72-year-old woman, happily married for 50 years and a respected kindergarten teacher, had recently been prescribed Paxil, along with Ambien and Ativan. She abruptly, and without memory, woke up in the middle of the night and stabbed her husband 200 times and was subsequently arrested for homicide. There was no jury trial; instead, a plea bargain was used to determine sentencing. Dr. David Antonuccio was called as an expert witness in her defense. He described Dr. David Healy's research documenting a significant increase in both suicidal and violent urges among some patients taking SSRIs, especially Paxil. He argued that this woman's bizarre behavior was consistent with a drug-induced dissociative or fugue state. Based in part on David's testimony, the charge was reduced to manslaughter, and the judge sentenced her to time served, allowing her to return home to her children. For more on this topic: David Healy's Research on SSRIs and Homicidal Urge SSRIs Called on Carpet Over Violence Claims Black Box Warnings and Patient Rights David also emphasized the urgent need to revise Black Box warnings to reflect the full range of possible toxic or dissociative effects of psychiatric medications—not just suicidality. He has long advocated for a Patient Bill of Rights to ensure scientific transparency and informed consent. A Surprising Conversation with Dr. John Nash David shared a fascinating personal story about calling Dr. John Nash, whose life inspired the award-winning film A Beautiful Mind. In the movie, Nash's recovery from schizophrenia  is portrayed as medication-dependent. However, Nash told David directly that this was not true—the medication narrative was added to the script, possibly out of concern that portraying his recovery without meds might discourage viewers from taking prescribed medications. Nash said: "What saved me was the support of family and friends." Music, Truth, and "Buzz" David is also a talented songwriter. One of his songs, "Buzz," addresses the emotional and ethical issues surrounding electroconvulsive therapy (ECT). The inspiration came from a man in the Midwest who was legally ordered to undergo ECT against his will. A widespread public outcry ultimately convinced the judge to rescind the order. Forgiveness and "In the Air Tonight" One of David's favorite songs is Phil Collins' "In the Air Tonight," which he sees as a deeply spiritual musical meditation on forgiveness—a theme David considers one of the most powerful psychological forces we possess. David explains that the Phil Collin's song is about forgiveness, but more indirectly and specifically about the songwriter's inability to forgive. And yes—David sang it live for us on the podcast! You might be interested in this chapter that David coauthored on the science of forgiveness Thank you for joining us today. And heartfelt thanks to you, Dr. David Antonuccio, for your gifts of enlightened skepticism, ethical courage, incisive scientific thinking, and soulful musical talent. David, Rhonda, and David

Have you tried magnesium but felt like it didn't help—or even made things worse? Are you confused by all the different forms and dosages? In this episode, Ali and Becki break down how magnesium actually works in the body, why so many people think they “don't tolerate” magnesium, and why form, dose, and context matter far more than most realize. We also share the full story behind the reformulation of Relax & Regulate, our superstar magnesium product. You'll learn why we chose magnesium bisglycinate paired with myo-inositol, how this combination supports nervous system regulation, sleep, anxiety, blood sugar, and hormone balance, and why it's especially impactful for PCOS, perimenopause, and stress-driven symptoms.  Also in this episode: Why is magnesium so important? Signs of magnesium deficiency Testing magnesium status Cell Science Systems Micronutrient Panel Episode 440 What does HTMA say about your health with guest Kaely McDevitt Anxiety and Magnesium Deficiency Naturally Nourished Episode 470 SSRIs on the Rise The magnesium GABA connection GabaCalm How inositol supports serotonin Why the combination of magnesium and inositol for blood sugar balance Why magnesium deficiency is more pronounced in perimenopause Forms of magnesium and absorption Considerations of magnesium threonate Why glycine matters and antiaging effects Naturally Nourished Episode 331 Homocysteine and Methylation Dosage considerations 1 scoop for maintenance 2+ scoops for PCOS, constipation, high cortisol, pregnancy Kids can start with ⅛-¼ scoop as early as age 2-3 Teens ½-1 scoop to start for acne, anxiety, hormonal concerns This episode is sponsored by Naturally Nourished Relax and Regulate Relax & Regulate has always been a superstar for sleep, stress, and hormone support, and we've taken a good thing and made it even better! We've seen incredible results with 1000's of clients using Relax and Regulate literally every day for 10+ years now.    We have increased magnesium bisglycinate from 200 mg to 250 mg to match clinical sleep research dosing, kept myo-inositol at the full 4-gram therapeutic dose, and improved the supporting ingredients so the entire formula is better absorbed, better tolerated, and more aligned with what we're seeing clinically every day. Use code RELAX15 to save 15% on our reformulated Relax and Regulate!

This episode is a raw, unscripted deep dive into men's mental health, toxic masculinity myths, anxiety, depression, fatherhood, money stress, and why modern mental health systems continue to miss men entirely. Using recent Psychology Today articles and peer reviewed research, the conversation breaks down what toxic masculinity actually is, how rare it truly is, and why buzzwords without clear definitions are doing more harm than good. You'll hear real talk on why most men are not toxic, how anxiety often shows up as anger or withdrawal, and why many men feel misunderstood or dismissed by traditional therapy models. You can expect honest commentary on male vulnerability, financial pressure, provider identity, SSRIs, plant medicine, trauma, fatherhood, and why men struggle in silence until things fall apart. This episode challenges pop psychology, questions mainstream narratives, and opens up a much needed conversation about what men actually need to heal, lead, and stay present for their families. If you care about men's mental health, masculinity, relationships, fatherhood, purpose, or breaking generational patterns, this video will hit hard and make you think long after it endsDisclaimer: We are not professionals. This podcast is opinioned based and from life experience. This is for entertainment purposes only. Opinions helped by our guests may not reflect our own. But we love a good conversation.Become a supporter of this podcast: https://www.spreaker.com/podcast/2-be-better--5828421/support.

Ginny Yurich sits down with Dr. Nicole Cain—author of Panic Proof—for a conversation that makes anxiety feel less mysterious and a whole lot more workable. Nicole explains why panic is often protective, how to spot your early “pay attention” signals before you hit crisis mode, and why the same tool won't always work. You'll come away with practical ideas like building a “panic pack,” using cold to calm the nervous system, and simple brain-and-body resets that matter even more in a screen-saturated world. They also go deeper on hormones, sleep, SSRIs, and why creativity and movement can be real medicine especially for kids. Learn more about Dr. Cain and her work at drnicolecain.com, get a copy of her book Panic Proof, and check out her podcast Holistic Inner Balance. Learn more about your ad choices. Visit megaphone.fm/adchoices

#307 Raul Pastrana is a degree-qualified naturopath specializing in fertility and reproductive health, with a particular focus on male fertility—an area that's often overlooked in the fertility conversation. He works closely with individuals and couples through preconception care, IVF preparation, and natural conception, creating tailored treatment plans based on semen analysis, blood pathology, and each person's unique circumstances. Raul is the author of The Male Factor: Fertility is a Shared Responsibility, where he explores how men can actively influence fertility outcomes and provides practical strategies to improve sperm health. Drawing on his background as both a naturopath and personal trainer, Raul has a gift for translating complex health information into actionable changes that people can actually integrate into their daily lives. He is passionate about shifting the narrative around fertility from being solely a "women's issue" to recognising it as a shared responsibility that requires equal investigation and treatment for both partners. In this episode, we cover: Why male factors contribute to at least 50% of infertility cases, yet women carry the burden of investigation and treatment  How sperm health impacts not just conception, but pregnancy loss, complications, and long-term child health The 72-74 day sperm production cycle and why this gives men unique leverage to improve outcomes quickly What's actually being measured in a semen analysis—and why "normal" reference ranges are based on the 5th percentile DNA fragmentation: the critical test that's often overlooked and what it reveals about fertility potential The main factors that influence sperm health: medications (SSRIs, finasteride, ibuprofen), alcohol, antibiotics, and lesser-known culprits The seminal microbiome: what healthy versus dysbiotic looks like and how gut health influences reproductive health Real case studies of dramatic sperm improvements after addressing underlying factors Why proper testing and preconception care matter even when pursuing IVF   If you or someone you know is navigating fertility challenges—or simply wants to optimize reproductive health—this episode offers practical, evidence-based insights that could change outcomes.     Pre-order The Male Factor: https://www.rhreproductivehealth.com/bookstore Rauls website https://www.rhreproductivehealth.com/our-team , Rauls instagram https://www.instagram.com/raulpastrana_hormonalhealth/?hl=en   WORK WITH ME: Book a 1:1 Consultation: https://www.lyndagriparic.com/book-an-appointment/  Shop BetterMe Tea: https://www.lyndagriparic.com/shop/ Website: https://lyndagriparic.com Instagram: https://www.instagram.com/lynda_griparic_naturopath/     This content is for educational purposes only and is not intended as medical advice.

In this episode, we explore a critical drug interaction: SSRIs combined with anticoagulants increase major bleeding risk by 35-47%. Should age and sex change our prescribing decisions? We break down the evidence from nearly 100,000 patients and discuss safer antidepressant alternatives for high-risk individuals. Faculty: Paul Zarkowski, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.75 CME: Quick Take Vol. 77 Do SSRIs Increase Major Bleeding Risk with Oral Anticoagulants?

#197 - How to Reverse Bone Loss Naturally — With 4 Clinically Proven Nutrients to Prevent Fractures. Interview with Dr. John Neustadt   Why Calcium Isn't the Answer to Strong Bones (and What Actually Is) — with Dr. John Neustadt If you've ever been told, “Just take calcium for your bones,” this episode is going to blow your mind. Lisa sits down with Dr. John Neustadt, naturopathic doctor, bestselling author of Fracture-Proof Your Bones, and founder of NBI Health, to uncover what really causes — and reverses — osteoporosis. It turns out, bone health isn't just about bone density. And the scary truth? The standard “treatments” may actually make bones more brittle. From medication-induced bone loss to how to choose supplements that actually work (and aren't a waste of money), Dr. Neustadt breaks down the science in a way that's refreshingly clear — and shockingly empowering. You'll learn:

Welcome to Resiliency Radio with Dr. Jill Carnahan, where today's episode takes you behind the scenes of ketamine therapy—one of the most promising and misunderstood breakthroughs in modern mental health care. Dr. Jill is joined by Dr. Jennifer Ellice, a board-certified emergency medicine physician and founder of Golden Afternoon Clinic. In this candid and eye-opening conversation, Dr. Ellice shares her unconventional journey from emergency medicine burnout during COVID to specializing in trauma-informed ketamine therapy for treatment-resistant depression, anxiety, PTSD, chronic pain, and suicidal ideation.

Dr. Read Montague, PhD, is a professor and director of the Center for Human Neuroscience Research at Virginia Tech and an expert in how dopamine and serotonin shape human learning, motivation and decision-making. We discuss how they impact focused effort in the context of short- and long-term goals of all kinds. Also, how SSRIs and low-effort, high-engagement activities reduce the rewarding properties of dopamine, and how AI algorithms are revolutionizing understanding of the brain. Episode show notes are available at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Joovv: https://joovv.com/huberman Function: https://functionhealth.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Read Montague (00:02:54) Dopamine, Motivation & Learning (00:08:49) Reward Prediction Error, Expectations (00:12:24) Sponsors: David & Joovv (00:14:54) Foraging, Dating, Expectations vs Outcomes; AI (00:23:36) Dopamine, Expectation, Motivation; Forward Drive; Dopamine "Hits" (00:29:58) Baseline Dopamine & Fluctuations; Parkinson's Disease (00:34:36) Movement, Urgency; ADHD, Bee's Dance, Explorer vs Focus Mode (00:42:29) Sponsor: AG1 (00:43:40) Social Media, ADHD; Explorers vs Task-Based, Combat (00:50:54) Effort, Learning; Social Media & Phones, Resisting Behaviors (01:01:36) Serotonin & Dopamine, Opponency, SSRIs (01:11:21) Hunger, Dopamine; Negative Feedback, Learning, Trauma; Torture (01:18:34) Drugs of Abuse & High Dopamine (01:19:48) Sponsor: Function (01:21:35) Trauma & Dopamine Adaptation (01:27:34) SSRIs, Dopamine, Positive Experiences (01:29:50) Deep Brain Stimulation; Measuring Dopamine & Serotonin in Humans (01:36:16) Sleep; Divorce; Science is a Contact Sport (01:45:14) Long-Term Motivation, Learning How to Fail, Tool: Kids & Sports (01:54:14) Sponsor: LMNT (01:55:34) Meditation, Breathing, Learning; Dopamine as a Currency (02:04:38) Function of Sleep, Motivation; Time Perception & Dopamine, Tracking Time (02:13:18) LLMs, AI, Uses & Problem Solving (02:18:33) Future Projects, Commercial Brain-Machine Interfaces; Concentration (02:25:57) Dopamine "Hits"?; Depression & Schizophrenia; Quitting (02:30:17) Dopamine & Serotonin Misunderstandings; Internal Satisfaction; Motivation (02:35:58) Serotonin Syndrome; Acknowledgements (02:38:31) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Alecia explores the critical intersection of women's mental health, ADHD, and reproductive psychiatry—an area where science is only beginning to catch up with women's lived experiences. Alecia's journey into psychiatry began in Sacramento, California, where she witnessed profound disparities in healthcare access across diverse communities. After seeing loved ones struggle with both physical and mental illness, she pursued medicine with a mission. During medical school, she gravitated toward geriatric psychiatry, drawn to the complexity of caring for older adults. But during residency, her focus began to shift as she became fascinated by something even more fundamental: the intricate dialogue between mind and body. This growing interest led her to consultation-liaison psychiatry, formerly known as psychosomatic medicine, where she served as chief resident. The field gave her a lens to understand how physical illness shapes mental health and vice versa—a perspective that would profoundly inform her later work. She went on to complete a consultation-liaison psychiatry fellowship at the University of Chicago, followed by specialized training in reproductive psychiatry. Alecia's attention to health disparities guided her toward women's and minority mental health, populations that remain vastly underfunded and underresearched. In her clinical work, she began noticing a troubling pattern: many patients struggling financially, physically, and emotionally actually met criteria for ADHD, yet had never been properly identified or treated. These missed diagnoses often compounded existing challenges, leaving people to navigate life with an invisible burden they didn't understand. In our conversation, Alecia illuminates why girls with ADHD are so often overlooked. While boys typically display hyperactive, disruptive symptoms that demand attention, girls more commonly present with inattentiveness—daydreaming, losing track of conversations, internal restlessness—symptoms easily misattributed to anxiety or depression. This diagnostic blind spot means girls are less likely to receive appropriate medication and more likely to struggle silently through years of self-blame. Alecia then guides us through the remarkable role hormones play in ADHD across the female lifespan. She explains how estrogen acts as a neuroprotective force, supporting the neurotransmitter systems that govern focus and impulse control. During the menstrual cycle, as estrogen and progesterone fluctuate, women with ADHD experience predictable shifts: heightened impulsivity and hyperactivity when estrogen dips after ovulation, and increased inattention, depression, and anxiety when both hormones plummet before menstruation. Strikingly, about sixty percent of women with ADHD also meet criteria for Premenstrual Dysphoric Disorder, underscoring just how intertwined hormones and mental health truly are. The postpartum period presents another vulnerable window. When estrogen declines after delivery, previously manageable or even unrecognized ADHD symptoms can suddenly intensify, leading to new diagnoses during what is already a demanding transition. Alecia thoughtfully discusses navigating stimulant medication during pregnancy, emphasizing that treatment decisions must honor each woman's unique circumstances while weighing risks and benefits for both mother and baby. As women approach perimenopause and menopause, declining and erratic estrogen levels can trigger cognitive changes, mood shifts, and worsening ADHD symptoms—yet clinical guidelines for diagnosis and treatment in this population remain virtually nonexistent. Alecia addresses the ongoing debates around hormone replacement therapy, noting that timing matters: estrogen therapy initiated earlier may offer benefits with fewer risks than when started later in life. She also discusses how certain SSRIs may help manage perimenopausal symptoms by supporting neurotransmitter function. What emerges most powerfully from this conversation is Alecia's compassion and her insistence on one fundamental principle: believe women. Listen to their experiences. Include their families in care. The science, she acknowledges, still has considerable catching up to do—but in the meantime, women deserve to be heard, validated, and treated with the individualized, evidence-informed care that respects the full complexity of their lives. Alecia Greenlee, MD, MPH is a board-certified psychiatrist who brings both rigorous training and deep humanity to her work with women navigating ADHD and co-occurring mental health conditions. After earning her medical degree from UC San Francisco, she completed her psychiatric residency at Harvard Medical School/Cambridge Health Alliance, where she served as chief resident in consultation-liaison psychiatry and developed expertise in collaborative care and mental health services for vulnerable populations. She went on to fellowship training at the University of Chicago, first in consultation-liaison psychiatry and then in reproductive psychiatry, gaining specialized knowledge in how the body and mind interact throughout women's lives. Allecia specializes in comprehensive psychiatric evaluation and evidence-based treatment for adults, with particular expertise in how hormonal changes throughout the female lifespan—from menstrual cycles to pregnancy to perimenopause—influence ADHD symptoms and overall mental health. Her commitment to health equity drew her to focus on women's and minority mental health, populations often underserved by research and clinical resources. She approaches each patient with cultural attunement and warmth, creating collaborative, safe spaces where people from all backgrounds feel genuinely heard. Her practice reflects a commitment to whole-person care that considers not just psychiatric symptoms, but the complex interplay of biology, identity, life circumstances, and medical conditions that shape each individual's treatment needs.

SSRI antidepressants are one of the most harmful medications on the market, and because of just how many people they are given to (often for no good reason as only a minority of patients benefit from SSRIs) they have had a profound effect on the consciousness of our entire society This article will review some of the more common side effects of SSRIs (and SNRIs), such as losing the ability to have sex, becoming numb to life, becoming severely agitated or imbalanced (sometimes to the point one becomes violently psychotic or commits suicide), losing your mind, and the development of birth defects Like many other stimulant drugs (e.g., cocaine) SSRIs can be very difficult to quit. Because of this, patients frequently get severely ill when they attempt to stop them (withdrawals affect roughly half of SSRI users). Worse still, it is often extremely difficult to withdraw from them and very few doctors know how to safely facilitate this Due to widespread denial in psychiatry about the issues with their drugs the common SSRI side effects (e.g., withdrawals) are often misinterpreted as a sign the individual had a pre-existing mental illness and needs more of the drug — which all too often then leads to catastrophic events for the over-medicated patient This article will provide the critical information SSRI patients are rarely warned about and resources for patients already trapped in challenging mental health situations  

Dr. Joanna Moncrieff is a British psychiatrist and author of “Chemically Imbalanced: The Making and Unmaking of the Serotonin Myth.” She challenges the long-held belief that depression is caused by a lack of the hormone serotonin.“The serotonin myth … was first put out there in the 1960s, then picked up by the pharmaceutical industry in the 1990s and widely propagated by them as part of their campaign to sell SSRIs, their new generation of antidepressants,” she said.Contrary to what many people still believe, there's no evidence that depression is caused by a lack of serotonin in the brain, Moncrieff said.“A few years ago, we published what's called an umbrella review, a sort of meta review of all the different areas of research that have looked at this. … And we show that there is no consistent or convincing evidence in any of these areas of research for any association between serotonin and depression. So hence, the idea is a myth,” she said.In our interview, she explains how this narrative took hold and how it reshaped modern psychiatry.So what causes depression if not a lack of serotonin? Dr. Moncrieff, who is a professor of critical and social psychiatry at University College London, regards depression as “meaningful human reactions to the circumstances of life now, and that is indeed how people used to think about them.”It's not a biological disease, she said, but a normal reaction that anyone may experience at times throughout life.“It's not something that we naturally just get over in a couple of weeks. It can take weeks and months of grieving, even for a short-term relationship that's finished.”To label deep sadness as a pathological medical condition that needs to be fixed with drugs is the wrong approach and precludes seeing a person “who is suffering, who is going through a period of difficulty and trying to work out what that is and how we can support them with it,” Moncrieff said.Views expressed in this video are opinions of the host and the guest, and do not necessarily reflect the views of The Epoch Times.

Three facts are scientifically undisputed: Serotonin is essential for fetal brain development. SSRIs disrupt the serotonin system. SSRIs freely cross the placenta. So why are pregnant women being told these drugs carry "little or no risk"?In this rare head-to-head debate, Dr. Adam Urato—maternal-fetal medicine specialist and FDA expert panelist—faces off against Dr. Robert Chen, a psychiatry resident willing to do what most of his colleagues won't: step into the arena and defend the establishment position.What unfolds is a striking conversation where both physicians actually agree on more than you'd expect—including that informed consent is failing pregnant women, that the chemical imbalance theory is dead, and that "untreated depression" is a misleading frame designed to sell drugs. The uncomfortable question neither side can fully answer: If SSRIs are correcting depression, why does the research show worse outcomes for women who stay on them?This isn't anti-medication propaganda. It's the conversation your doctor isn't trained to have with you.Listen before you fill that prescription. Visit Center for Integrated Behavioral HealthDr. Roger McFillin / Radically Genuine WebsiteYouTube @RadicallyGenuineDr. Roger McFillin (@DrMcFillin) / XSubstack | Radically Genuine | Dr. Roger McFillinInstagram @radicallygenuineContact Radically GenuineConscious Clinician CollectivePLEASE SUPPORT OUR PARTNERS15% Off Pure Spectrum CBD (Code: RadicallyGenuine)10% off Lovetuner click here

As 2026 gets underway we know that many take time around this new beginning to improve not only their physical, but also their mental health. With that in mind, we're rerunning an episode with Leanne Williams on the future of depression care. Leanne is an expert on clinical depression and is working on new ways to more precisely diagnose depression in order to develop more effective treatment. For anyone who has suffered from depression or knows someone who has, it's an episode that provides hope for what's on the horizon. We hope you'll take another listen and also share this episode with anyone who you think may benefit from the conversation. Episode Reference Links:Stanford Profile: Leanne WilliamsConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Leanne Williams, a professor of Psychiatry and Behavioral Science at Stanford University.(00:01:43) What Is Depression?Distinguishing clinical depression from everyday sadness.(00:03:31) Current Depression Treatment ChallengesThe trial-and-error of traditional depression treatments and their timelines.(00:06:16) Brain Mapping and Circuit DysfunctionsAdvanced imaging techniques and their role in understanding depression.(00:09:03) Diagnosing with Brain ImagingHow brain imaging can complement traditional diagnostic methods in psychiatry.(00:10:22) Depression BiotypesIdentifying six distinct biotypes of depression through brain imaging.(00:12:31) Cognitive Features of DepressionHow cognitive impairment plays a major role in certain depression biotypes.(00:14:11) Matching Treatments to BiotypesFinding appropriate treatments sooner using brain-based diagnostics.(00:15:38) Expanding Treatment OptionsPersonalizing therapies and improving treatment outcomes based on biotypes.(00:19:03) AI in Depression TreatmentUsing AI to refine biotypes and predict treatment outcomes with greater accuracy.(00:22:15) Psychedelics in Depression TreatmentThe potential for psychedelic drugs to target specific biotypes of depression.(00:23:46) Expanding the Biotypes FrameworkIntegrating multimodal approaches into the biotype framework.(00:27:29) Reducing Stigma in DepressionHow showing patients their brain imaging results reduces self-blame and stigma.(00:29:38) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The anti-ICE protests, sparked by the fatal shooting of Renee Good, presently happening throughout the USA, don’t appear to be dying down. So why does it appear to be mostly white women protesting? There are several theories as to why that is, but one is that a lot of these women are unmarried and childless but still have the instinct to mother, so they see ICE agents as their ex-husbands and the illegal immigrants as the children they don’t have. Plus, they’re sick and thus overly medicated on a chemical cocktail of antidepressants and SSRIs. The ICE agents are there to do their job, which is to enforce the law, and process warrants for people who are in the country illegally. So why are so many white women angry about it? Listeners certainly have their opinions about why this is. Meanwhile, what’s with all the whistles?See omnystudio.com/listener for privacy information.

Dr. Keith Humphreys is a professor of psychiatry and behavioral sciences at Stanford School of Medicine and a leading expert on treating addictions, drug laws and policy. We discuss all the major addictive substances and behaviors, including alcohol, opioids, gambling, stimulants, nicotine, cannabis and more, focusing on how genetics and certain use patterns shape addiction susceptibility. We discuss the best evidence-based tools for recovery, from 12-step programs to emerging treatments such as psychedelics and ibogaine. Anyone interested in making better choices for their health and/or seeking to avoid or overcome addictions ought to benefit from this episode. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:58) Keith Humphreys (00:03:22) Addiction; Genetic Risk (00:09:14) Alcohol Use Disorder & Alcoholism; Genetic Predisposition & Addiction Risk (00:18:03) Sponsors: David & BetterHelp (00:20:37) Women & Alcohol Use; Young Adults; Cannabis Use (00:23:36) Health Benefit to Alcohol?, Red Wine, Cancer Risk; Social Pressure (00:31:47) Alcohol in Social Gatherings, Social Anxiety, Vulnerability, Work & Dates (00:37:41) Old vs New Cannabis & THC Levels; Smoked vs Edible Forms (00:44:38) Cannabis & Psychosis Risk; Cardiac Health; Youth Cannabis Use & Transition to Adulthood (00:52:29) Sponsor: AG1 (00:54:13) Industries of Addiction, Regulation; Gambling, Slot Machines, Novelty; Casinos (01:05:28) Decriminalization vs Legalization; Cannabis, Gateway Drug? (01:08:50) Psylocibin or LSD, Addiction Treatment; Microdosing, Clinical Trial Challenges (01:18:58) Sponsor: Helix Sleep (01:20:32) Brain Plasticity & Age; Ketamine, Depression, Transcranial Magnetic Stimulation (TMS) (01:28:10) SSRIs, Mass Shootings, Suicide, Side Effects; Drug Approval; Ibogaine & PTSD (01:36:10) Caffeine Addiction?; Stimulants & Rehab; Prescription Stimulants & ADHD (01:44:04) Nicotine, Mistaking Withdrawal for Benefit (01:47:24) Sponsor: LMNT (01:48:44) Tool: How to Talk to Someone with Addiction (01:55:23) Perception of Addicts, Character Defect, Pain (02:00:58) Overcoming Addiction, Immediate Rewards, AA; Addict & Co-Dependency? (02:09:53) Longterm Drug Use, Dopamine, Cues & Relapse; Social Media (02:16:21) Brain Stimulation, TMS; Homelessness, Substance Use & Rehab (02:26:11) Addiction Treatment Policy, Rehab & Insurance (02:29:08) Tool: 12-Step Programs, AA, Accessibility & Benefits (02:38:08) AA, Higher Power, Cult?; Flexibility, Tool: Open AA Meetings (02:44:38) GLP-1s, Weight Loss, Alcohol Addiction; Pharmaceutical Advertisements (02:52:39) Social Media Addiction, Tool: Avoiding Social Media Strategies (02:58:36) “Failure to Launch”, Youth, Video Games, Social Media; Recovery Pathways (03:04:13) AA as an Action Program, Tool: Try Different AA Meetings (03:08:21) Hospice, Death, Overcoming Fear of Death (03:13:54) Addiction to Escape Death?, Desire for Oblivion (03:18:11) Men vs Women & Addiction; Lying; Relapse; Fentanyl & Addiction Advice (03:24:27) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Contributor: Taylor Lynch, MD Educational Pearls: What is tramadol and how does it work? Tramadol is a Schedule IV opioid analgesic used for moderate pain and is often perceived as safer than other opioids due to lower abuse potential. It is a prodrug with weak direct μ-opioid receptor activity. The parent compound also inhibits serotonin and norepinephrine reuptake, giving it SSRI/SNRI-like properties. Tramadol is metabolized by CYP2D6 into O-desmethyltramadol (ODT), which has significantly stronger μ-opioid receptor agonism than the parent drug. What are the concerns with tramadol? Ultrarapid CYP2D6 metabolizers (more common in Middle Eastern and North African populations) rapidly convert tramadol to ODT, increasing the risk of opioid toxicity. Poor CYP2D6 metabolizers generate little ODT and may experience primarily serotonergic effects, increasing the risk of serotonin syndrome, especially when combined with SSRIs or SNRIs. CYP2D6 inhibitors (e.g., bupropion, paroxetine, terbinafine, celecoxib) can block tramadol's conversion to ODT, potentially precipitating opioid withdrawal or increasing serotonergic toxicity. Tramadol is also associated with an increased risk of first-time seizures, even at therapeutic doses. Key takeaways Tramadol's effects are highly unpredictable, varying from minimal analgesia to exaggerated opioid effects depending on metabolism. Drug–drug interactions can lead to serotonin syndrome or opioid withdrawal. Despite its Schedule IV classification and reputation for safety, alternative analgesics may be preferable in many patients. References DailyMed - TRAMADOL HYDROCHLORIDE tablet, coated. Accessed January 10, 2026. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=61fb5ba7-6896-4ee4-83de-caee69b06a8e#ID57 Dean L, Kane M. Tramadol Therapy and CYP2D6 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, eds. Medical Genetics Summaries. National Center for Biotechnology Information (US); 2012. Accessed January 10, 2026. http://www.ncbi.nlm.nih.gov/books/NBK315950/ Aly SM, Tartar O, Sabaouni N, Hennart B, Gaulier JM, Allorge D. Tramadol-Related Deaths: Genetic Analysis in Relation to Metabolic Ratios. J Anal Toxicol. 2022;46(7):791-796. doi:10.1093/jat/bkab096 Summarized and edited by Dan Orbidan OMS2 Donate: https://emergencymedicalminute.org/donate/ Join our mailing list: http://eepurl.com/c9ouHf  

Dementia is often a highly burdensome disease process for patients, their caregivers and families, and the community at large. Palliating symptoms and providing guidance surrounding advance care planning and prognostication are integral components of the management plan. In this episode, Katie Grouse, MD, FAAN, speaks with Neal Weisbrod, MD, an author of the article "Neuropalliative Care in Dementia" in the Continuum® December 2025 Neuropalliative Care issue. Dr. Grouse is a Continuum® Audio interviewer and a clinical assistant professor at the University of California San Francisco in San Francisco, California. Dr. Weisbrod is a neurologist at Hartford Healthcare with the Ayer Neuroscience Institute in Mystic, Conneticut. Additional Resources Read the article: Neuropalliative Care in Dementia Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Grouse: This is Dr Katie Grouse. Today I'm interviewing Dr Neal Weisbrod about his article on neuropalliative care in dementia, which appears in the December 2025 Continuum issue on neuropalliative care. Welcome to the podcast, and please introduce yourself to our audience.  Dr Weisbrod: Thank you. I'm really excited to be here. I'm Neal Weisbrod. I'm a neurologist and palliative care physician currently working at Hartford Healthcare in Mystic, Connecticut. Dr Grouse: To start, I'd like to ask why you think it's important that neurologists read your article? Dr Weisbrod: The primary reason I think it's really important to read the article is because these are just really common problems that neurologists run into in clinical practice. So, Alzheimer disease and many other dementias are extremely common, and managing the burdensome symptoms and the complex discussions that we have to have with the patients and their families as they go through the course of dementia is something that is very common in clinical practice. And so my hope is that by reading this article, clinicians will pick up a few tools, a few new ideas for how to make these conversations easier and for how to help these patients get through the disease with a little bit less suffering. Dr Grouse: I learned a lot from reading your article, and I really encourage our listeners to check it out. But I was curious what you feel that you discussing your article would come as the biggest surprise to our listeners? Dr Weisbrod: So, I think that the most surprising thing a lot of people will see reading this article is the section on prognosis. A lot of times it seems families are counseled, when they're talking about the prognosis of Alzheimer disease, that it could be ten years or longer. But really, the data show that for many patients, the median prognosis is closer to three to eight years. And that is a little bit longer for Alzheimer disease than many other types of dementia, but also gets significantly shorter as patients get older. So, we're looking at a closer to three-year median prognosis for patients who are over eighty-five, whereas patients in their sixties are probably closer to the eight or nine-year median prognosis. And so I think that piece will hopefully help people give a little bit more accurate counseling about prognosis.  Dr Grouse: I'm glad you brought that up because I was wondering, why is it so important that we are careful to make sure that we're giving prognostic information for our patients and maybe even updating it as their clinical status changes? Dr Weisbrod: I think first of all, it's a really common thing that patients and families are thinking about and worried about. They don't necessarily always seem to ask as much as they want to know. I think there's a lot of fear around that conversation, even though it's really important. And then there's also often tension between the family and caregivers tend to want to know more than patients do. I think that it really helps people plan for the future as well as possible to know what their future might be. And we have a lot of limitations in predicting the future, but using the best information we can, laying out what we think the likely range is, allows people to make a lot more clear plans for their future. Dr Grouse: I'd imagine it's also pretty helpful for hospice referrals, too, having that data.  Dr Weisbrod: Yeah, definitely. And there's a lot of angst about when to refer patients who have dementia to hospice. The most important thing I think about when I'm making a hospice referral is that I don't have to be right. And I think it takes a lot of that concern off to just say, all I'm doing is making a connection, getting someone who's potentially interested in the hospice, who has a really advanced serious illness connected to a hospice agency. And then they can go through the full evaluation with the hospice and the hospice medical director and determine whether they're eligible. So, I think there are really helpful thresholds to think about that would be a good trigger. Like a patient who we think has advanced dementia, who has a hospitalization for pneumonia or a fracture of the hip or some other really serious acute medical condition, I think is a really good trigger to start to think about hospice. But most importantly, it's just the connection, and I tell the patients that upfront. I tell them that you're going to have a conversation and we'll decide whether you're a good fit, and if not, the hospice will usually just check in with you over time and decide when is the right time in the future. Dr Grouse: That's really helpful. And I think just a really great reminder to our listeners about thinking about hospice sooner or at certain critical points in their patient care rather than waiting, maybe, before it's gone on too long and may be of less use later on. I was wondering, in your own clinical practice, what do you think is the most challenging aspect of providing care to patients with dementia?  Dr Weisbrod: I think this one's easy. I would say managing the time has to be the most difficult part. I think that taking care of patients who have dementia is time-consuming. There's a lot of different priorities that we have to manage the time around. How much time are we going to spend doing cognitive testing? How much time are we going to spend doing counseling? How much time are we going to spend making up a treatment plan and discussing medications? How much time are we going to spend on advanced care planning? And the way I try to combat that is really just trying to think about what I'm going to prioritize in a certain visit and not try to accomplish everything. I'll tell patients and their families, the next time you come in, we're going to have a conversation focusing on advanced care planning. Or, the next time you come in, we're going to sit down and try to talk through all the questions you have about what the future might hold. That way I in that visit, I don't feel like, oh, I have to do updated cognitive testing and I have to review all the next steps in medication, and that allows me to take it in more bite-sized chunks. Dr Grouse: You made some of the great points, and specifically you mentioned advanced care planning. Your article makes a really strong case for the importance of advanced care planning, yet you definitely acknowledge the many barriers to initiating discussions that clinicians face. In your patients with dementia, can you walk us through how you integrate discussions about advanced care planning with your patients and their families?  Dr Weisbrod: Yeah, I think this is still something that is evolving in my practice, and I don't think there's any perfect way of doing it. I think there's a lot of right ways of doing it, and as long as we're thinking about it a lot and bringing it up periodically, that's probably the best. What I try to do, though, is after I discuss what I think is the most likely diagnosis with patients and their families, I try to have a fairly close follow-up visit after that. Allow them to digest that information, to often do a little bit of their own research, to talk about it as a family. And then when they come in for that next appointment, I try to at least lay some groundwork about advanced care planning, asking them what they've completed already, and then based on what they've already done to that point, talking to them about what I think the next step would be. If they have done nothing, usually it's just, hey, I really think you should start to think about who would be making decisions for you if you lose the ability to make your own decisions and counsel them about power of attorney paperwork and establishing a healthcare surrogate. When it's patients who have already done some of that initial prep, I think that it's really important to keep in mind it's a longitudinal discussion and you can take it in small pieces over time. Often that helps because you can really establish that rapport and that trust. And then I like to just keep checking in whenever there's major changes in the patient's health or condition, like admission to the hospital or transfer to an assisted living facility or memory care clinic. Those are good times to remember, hey, I really need to revisit this conversation.  Dr Grouse: It's probably good to also mention another really important point from your article, which was that impairment of decision-making in patients with dementia can actually start significantly even in the phase of mild cognitive impairment. Yet these patients will need to make many medical decisions with their neurologist as they go through this journey. How can we make sure our patients have capacity and make decisions appropriately regarding their care? Dr Weisbrod: Yeah, I think that's a definite challenge of taking care of patients with cognitive disorders of any type, including those with stroke and multiple sclerosis, that have some cognitive impairment. In my opinion, the most important way to help manage that is to make sure when we are making important decisions about the future that we're having a deep exploration of the values and the reasoning behind that. And definitely teach back is the most helpful way that I use to explore those values and the logic behind patients' decisions. So, I think we have to have a really low threshold to move on to a formal evaluation of capacity; if there's any inconsistency between what the patient's saying now and what their families say they've said in the past, or if they're having struggled to come up with a really clear logic behind their decision, then I think we have to have a low threshold to move on to a formal evaluation of capacity. So, I think having the family involved, having other people who know the patient really well, usually helps identify some of those periods where it seems like the patient's not making the decision that really reflects their true wishes. Dr Grouse: Now I wanted to switch gears a little bit and get into the management of neuropsychiatric symptoms, which you spend a lot of time on and I think a lot of neurologists find very challenging. What are some nonpharmacologic approaches that can help patients with significant neuropsychiatric symptoms?  Dr Weisbrod: I really like the DICE paradigm for coming up with nonpharmacologic approaches. The DICE paradigm is an acronym. The D is Describe, I is Investigate, C is Create, and E is Evaluate. The idea is that we're exploring what's happening behind the symptoms, we're creating a plan to intervene, and then we're evaluating the outcome of that plan and creating a sort of feedback loop there. But ultimately, I think, when we're creating a solution, thinking about how we can change the environment is the most important thing. We have very limited ability to change the way that someone who has severe cognitive dysfunction reacts to their environment, but we can often change the environment to not produce that reaction in the first place. One example is with wandering behaviors. Trying to change the environment where you put locks that don't have deadbolts that you can use on the inside of the house, you have to have a key on the inside of the house, and then the family can put that key somewhere safe where the patient is not likely to find it and be able to unlock the door and wander out unsafely. I also think it's really important to acknowledge that as doctors, we are maybe not the best people to always have the answer when it comes to changing a patient's environment. And so, I think we really need to rely on the wisdom of support groups and other people who are going through the challenge of dementia. Our interdisciplinary care teams like social workers and nurses who have experience in managing dementia, and really try to plug the caregivers into as many of these avenues as possible so that they can learn from all of that community of wealth and not always rely on the doctor to have the answer. Dr Grouse: Switching gears to pharmacologic management, which is a lot of what we do for patients as neurologists. Thinking about agitation, pharmacologic management of agitation can be very challenging. And reading your article, it reminds me how disheartening it is to reflect and how modest the effect of the available options are, along with the many potential risks of their use, When nonpharmacologic interventions fail, what should neurologists recommend for their patients with agitation? Dr Weisbrod: Yeah, I definitely agree. It's every time I go back and look at this literature and look at what's new, it is a bit disheartening. But even in the face of all that, I really feel like SSRIs are my first-line therapy for most of these patients. I always try to ask myself what might be causing the patient discomfort that they are then manifesting as agitation because they don't have a better way of expressing themselves. Often, I feel like that's anxiety or depression or some other psychological symptom that we might be able to address with an SSRI. So, I tend to use sertraline and escitalopram, start those early and as long as patients are tolerating it, give it a really good trial. Outside of that, escalating to other pharmacologic approaches, even though there's such controversy in the data about antipsychotics and even though there are very real risks, sometimes I think we essentially do need a chemical sedative. And I think that it's important to have a very frank conversation upfront with the caregivers and the medical decision maker for that patient. Make sure we are counseling them on the risk, the increased risk of mortality, and also to make it a time-limited trial. So, I think that saying we're going to try this medication (if the patient's decision maker agrees, obviously) for a month or two months or three months. But I definitely wouldn't want them to just have an open-ended plan where they're going to stay on it indefinitely. It should have some end point where we say, hey, is this working or not? And if it's working, then we'd make a decision, is the improvement in quality of life worth the risks? And if we're not seeing that improvement, then we definitely need to stop it. Dr Grouse: That seems very reasonable. And then thinking more towards some of the other types of symptoms that can be really challenging, I was really surprised to see how often uncontrolled pain is a significant contributor in patients with dementia. And certainly, both uncontrolled pain and poor sleep can worsen cognitive function and neuropsychiatric symptoms in general. But of course, there's ongoing concerns about side effects of these therapies and how they can also potentially worsen things. How should we be approaching management of pain and insomnia or poor sleep in these patients?  Dr Weisbrod: I think the key is just to start with really low burden treatments and escalate carefully and start with low doses of higher risk medications. So, when I think the low burden treatments for pain, scheduling acetaminophen, 1000 milligrams every eight hours, seems like a trivial thing to do, maybe? But it's actually surprising how much scheduled acetaminophen can take the edge off of pain and might be able to avoid some of these flare-ups of neuropsychiatric symptoms, may be able to really improve that pain a little bit. I do think it really has to be scheduled, though. Trying to rely on patients who have significant cognitive dysfunction to use a PRN medication is going to lead to a lot of problems and undertreatment. And then on the sleep disorder side, I think starting with low-dose Trazodone and gradually increasing the dose of Trazodone as a really safe way of initially approaching the insomnia. And then only when it's a more refractory case do I reach for the high-risk medications. Like for pain, we're talking about opiates. I think there's a lot of very reasonable concern about using opioids in patients who have cognitive dysfunction. But if there is a really good reason to think that they have severe pain, like they have a past pain disorder, I think that just like with antipsychotics, there are definitely real risks to these medications. But at the end of the day, if we are improving someone's quality of life dramatically and the patient's medical decision maker is willing to take on those risks, then we're really doing the patients a favor. Dr Grouse: Now, another issue that you mentioned in your article, which I see a lot and often struggle with myself, is how and when to deprescribe certain types of medications such as cholinesterase inhibitors and memantine. Any tips or tricks to how to approach this?  Dr Weisbrod: My approach to this has also evolved a bit over the years. The new data that cholinesterase inhibitors may have a mortality benefit in patients with Alzheimer disease has changed my thinking a little bit. But there are still lots of situations where it's just too burdensome or patients seem to be having side effects. And so, I think about deprescribing. The most important thing in my mind is really thorough counseling before deprescribing with the patient's family and medical decision maker. I think that letting them know that we might actually be holding things more stable with the medication than we realize, there could be a flare-up, that we can resume the medication if that flare-up happens but we don't always guarantee getting back to the same point. I think having that conversation ahead of time will ward off some of the worst issues that you have afterwards. And then I think doing a taper of cholinesterase inhibitors over two weeks to a month is probably the most prudent because of some of the data about withdrawal and exacerbation of neuropsychiatric symptoms or cognitive worsening. Memantine, I think the data is a lot more shaky on withdrawal. And so, I think it's less important to gradually taper memantine. But I think that once again, just having the conversation upfront and letting the family know these are the things we have to look out for and these are the risks is going to be the most important. Dr Grouse: That's really helpful and a great strategy to take advantage of. Another, I think, really difficult topic that I wanted to ask you about was the discussion around nutrition and whether or not to consider putting in some type of a permanent tube for tube feeds. How do you approach that conversation? Certainly a difficult one.  Dr Weisbrod: Yeah, I think it's easily one of the most difficult conversations to have in the care of patients who have dementia. And there's so much emotion in the families when they're having this discussion. And I think really acknowledging there's a huge emotional piece of the conversation is one key piece. For families and caregivers, they're thinking, I don't want my loved one to starve to death. That's usually the most important thing in their mind. We have to address that concern in the conversation, or they're never going to get to a point of satisfaction with the decision that's being made. So, I think while there is still some controversy in the literature about artificial nutrition for patients who have dementia, the bulk of data indicates that it is not helpful for patients. It may exacerbate dementia, it leads to more restraint. And so, I think unless there's some reversible medical condition that we're just trying to do artificial nutrition to get them through, like, they have a stroke and we're expecting that their dysphasia is going to improve because of the stroke is going to heal. Those situations might be a good reason, but if we really think that the driving factor behind their dysphasia is their dementia, I think we should be guiding the families away from that. And I think that explaining that as dementia gets really advanced, the body is slowly shutting down. The body is not needing as much nutrition, and forcing more nutrition in has not been shown to help people who have dementia. Really putting it in that sort of language is going to help the families understand and be comfortable with that decision. I also think that it's really helpful to consider talking to families about what they can do and not have the entire conversation be about what we're not doing or not putting in a feeding tube for artificial nutrition. So, I think really good counseling about, we can do comfort feeding, we can expand what food we're giving the person who has dementia and really focus on foods that they really enjoy and not worry so much about the health and nutrition anymore. I think that focus on what they can take control of can also help make the decision easier for families.  Dr Grouse: I really like that approach. And I agree, it does seem that it being such an emotional decision with just so much a concern about this underlying feeling of not caring for their family member. I think that is a really great way to look at it  and to kind of start off that conversation. Now, I'd love to hear more about what drew you to this field when you first got into your career as a neurologist. Dr Weisbrod: I had an interesting journey to doing neuropalliative care. Definitely didn't know that's what I was going to do when I started neurology residency. At University of Rochester, we had amazing palliative care physicians that were involved in medical school, and so I got a little bit of exposure to it early on. Then when I was in neurology residency, I first of all realized that I really enjoyed making sure that what we were doing respected a patient's wishes. And so, as other people seemed to run away from those conversations, I was really drawn to them. And so that definitely made me realize that that might be more of the right field for me. But also, as I went through neurology residency, I really discovered that I love so many different things in neurology, and that made me not want to subspecialize and focus on a narrower set of conditions in neurology. So, doing palliative care fellowship was a really good way of getting a specialist tool set and expanding my knowledge in one area, but staying a neurologist, generalist. And I think it also really enhances a lot of the other things I do in neurology. It gives me a lot of additional skills on how to counsel patients and how to prepare for the future in general. I think there's a lot about just good bedside manner in palliative care education. I feel like it helped me become a better neurologist, and I decided that I really loved the palliative care piece as well.  Dr Grouse: Well, we're certainly all grateful that you found this aspect of your career and have been able to share the skills you've honed with us as well. And we really appreciate you taking the time to talk with us about your excellent article today, which I encourage everybody to read.  Dr Weisbrod: Yeah, thank you. It's been wonderful to be on, and I hope that people can take away a few small points from the article. Dr Grouse: Again, today I've been interviewing Dr Neal Weisbrod about his article on neuropalliative care in dementia, which appears in the December 2025 Continuum issue on neuropalliative care. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Former New York Times reporter and now independent journalist Alex Berenson is the author of “Tell Your Children: The Truth About Marijuana, Mental Illness, and Violence.”In this episode, we dive into the debate around cannabis and THC and President Donald Trump's recent executive order directing the Drug Enforcement Administration (DEA) to reclassify marijuana from a Schedule I to a Schedule III drug.Berenson argues that it's a bad move. Schedule I substances are defined as having high potential for abuse and no accepted medical use. Schedule III substances, in contrast, have medical uses and are regarded as having only moderate to low potential for abuse.Rescheduling marijuana sends the wrong signal, Berenson says: “Do we want to be a society that, in general, encourages drug use?”He believes the use of drugs should be stigmatized, including the use of marijuana: “In the U.S. we can't stigmatize. And not to stigmatize in this case, as in so many cases, means we can't be honest.”In my interview with Berenson, he provides an overview of the dangers of marijuana use and why these have increased dramatically over the last half-century.“Fifty years ago, cannabis that was in a joint that you smoked at Woodstock ... that might have been 1 or 2 percent THC, so a few milligrams of cannabis in a joint. ... When I was growing up in the ‘80s or in the '90s, it might have been 5 percent THC. Now, if you go into a dispensary ... the bud tender will sell you a product that is 20 percent to 30 percent THC, if it's flower cannabis,” he said.And if it's not smoked but vaped, then “that might be 95 percent THC. This is not a plant at all. It's just a chemical to get you high,” Berenson said. “Now you can walk around with this little device and inhale massive amounts of THC, and that really is a change that has made the product a lot more dangerous.”There is also a well-established link, Berenson says, between high-potency, frequent marijuana use, and severe mental health impacts such as psychosis and schizophrenia.There's even research suggesting THC causes heart damage. “There is a link to myocardial infarction, heart attacks, and that link is pretty strong. You can find papers that show a 3x increase over a multi-year period,” he said.But what about its benefits as a pain reliever? Berenson said that he was surprised to discover that placebo-controlled studies showed only small and short-term pain relief effects.“What cannabis and THC are really good at is enhancing sensation ... but if you're in pain, in the long run, enhancing sensation actually is not a good thing for you. ... And so the idea that cannabis is a substitute or a way out of our opioid problem is just not true,” Berenson said.“We as a society have to ... be honest with ourselves about what we are doing and what we are encouraging kids to do,” he said.In our wide-ranging interview, we also discuss the overprescription crisis in America, the dangers of SSRIs, psychedelics, and stimulants such as Adderall that around 10 percent of teenage boys are taking in the United States, and his thoughts on vaccine policy in America.Views expressed in this video are opinions of the host and the guest, and do not necessarily reflect the views of The Epoch Times.

What happens when your family stages an intervention because they've been avoiding you 10 days every month?I'm sharing the story of a patient who had a complete breakdown at Christmas dinner. She snapped at her husband, her kids, her mom, her in-laws—everyone. A few hours later, her family told her: "We love you, but for 10 days every month, we actively avoid you."She came to me asking: Am I bipolar? Am I manic? What's happening to me?This is PMDD premenstrual dysphoric disorder. And when it collides with perimenopause, it becomes a perfect storm. This is not just PMS. This isn't you being dramatic. It's a real biochemical thing happening in your brain an abnormal response to normal hormonal changes.I discuss the science of PMDD: how GABA receptors respond to progesterone metabolites, why some brains are change sensitive, and why the hormonal volatility of perimenopause (erratic estrogen, declining progesterone, unpredictable timing) makes everything exponentially worse. I explain treatment options from luteal-phase SSRIs to Yaz to Duavee for refractory cases, and why tracking your symptoms for at least two cycles is critical for diagnosis.Highlights:Why "I feel like I'm watching myself burn down my life and can't stop it" is the hallmark of PMDD.The DRSP tracking tool: why you need 2 cycles to diagnose PMDD properly.Why Vitex (chasteberry) might help mood swings and breast pain.What Duavee is and why it works for women who can't tolerate progestins.Why Dr. Tammy Rowan calls PMDD a progesterone sensitivity issue.Ulipristal: the emergency contraception drug being studied for PMDD.If you've ever felt like your brain gets hijacked on a schedule, if you've felt completely out of control, this episode is for you. Track your symptoms. Find a clinician who takes cyclic mood symptoms seriously. You don't have to live like this. Please share this episode with someone you know might be experiencing this or a clinician you think would benefit from it.Resource:DRSPDr. Tami RowenGet in Touch with Me:WebsiteInstagramYoutubeSubstackMentioned in this episode:GSM CollectiveThe GSM Collective - Chicago Boutique concierge gynecology practice Led by Dr. Sameena Rahman, specialist in sexual medicine & menopause Unrushed appointments in a beautiful, private setting Personalized care for women's health, hormones, and pelvic floor issues Multiple membership options available Ready for personalized women's healthcare? Visit our Chicago office today. GSM Collective

In this episode of The Truth with Lisa Boothe, Lisa digs into America’s mental health crisis in light of the tragic deaths of Hollywood icon Rob Reiner and his wife Michele — allegedly involving psychiatric medication struggles. Board-certified psychiatrist and former FDA medical officer, Dr. Josef Witt-Doerring joins Lisa to discuss the risks of psychiatric drug over-prescription, hidden side effects of SSRIs and antipsychotics, the impact on youth and developing brains, withdrawal challenges, and how Big Pharma influences the mental health narrative. If you’re curious about the long-term effects of antidepressants, the limits of current research, and how to approach mental health treatment more safely and effectively — this episode is a must-listen. Learn more about Dr. Josef HERESee omnystudio.com/listener for privacy information.

In today's episode, your host, Jon LaClare, leads an important conversation that healthcare marketing rarely explains: the placebo effect and why it deserves far more attention. This discussion is inspired by the launch of Pluseebo, a transparent, intentionally humorous product designed to spark awareness around belief, expectation, and honesty in healthcare.While Pluseebo is lighthearted on the surface, its launch highlights a much deeper reality supported by published scientific research. Placebo responses can produce real, measurable biological effects in the body, including changes in brain chemistry, pain perception, and overall wellbeing. These effects are not imagined, and in many clinical trials they closely mirror the average performance of widely prescribed medications.Tune in as Jon breaks down what healthcare advertising often leaves out, including how modest the average benefit of some antidepressants, pain medications, sleep aids, and other common prescriptions can be when compared to placebo, and why side effects and transparency must be part of the conversation. Grounded in respected medical journals and FDA-reviewed data, this episode offers a research-driven perspective designed to inform, challenge assumptions, and elevate the discussion around modern healthcare. Don't miss this timely conversation on belief, biology, and why understanding the placebo effect changes how health products, treatments, and claims should be evaluated.In today's episode of the Harvest Growth Podcast, we'll cover:What the placebo effect actually is, and why it's not “fake.”What large studies reveal about SSRIs, opioids, sleep medications, anxiety medications, ADHD drugs, and statins.Why prescription drug commercials rarely tell the full storyHow transparency in healthcare affects trust and decision-makingHow Pluseebo is designed to spark honest conversations.To learn more about Pluseebo, visit Pluseebo.com.To be a guest on our next episode of the podcast, contact us today!Do you have a brand that you'd like to launch or grow? Do you want help from a partner that has successfully launched hundreds of brands totaling over $2 billion in revenues? Visit HarvestGrowth.com and set up a free consultation with us today!

Send us a textNeurobiology of maternal care in mammals: hormonal influences, stress effects & a study on psilocybin's unexpected effects during the postpartum period.Topics Discussed:Maternal care behavior in rodents: Nursing, pup retrieval, grooming, and nest-building, essential for altricial pups' survival; conserved across mammals but varies by species.Hormonal changes in pregnancy: Estradiol and progesterone surge then drop at birth, crossing the blood-brain barrier to enable infant attraction and care via gene expression and neuroplasticity.Brain circuitry for parenting: Medial preoptic area acts as a central hub, coordinating motivation and sensory inputs; present in both sexes but activated differently by hormones and experience.Stress impacts on mothers: Social stressors like male intruders dysregulate care, leading to frantic behaviors and avoidance; models human psychosocial stress linked to postpartum mood disorders.Sex differences in pup care: Mothers groom male pups more, influencing sexual behaviors, which effects future behavior.Psilocybin in postpartum mice: Single dose increased anxiety in mothers, showed no antidepressant effects, and transferred via milk, causing long-term anhedonia and impairments in offspring as adults.Serotonin system development: Early exposure to serotonergic drugs like psilocybin or SSRIs alters lifelong behavior, highlighting sensitive periods in brain reorganization.Practical Takeaways:Reduce postpartum stress through social support to enhance maternal bonding and minimize mood disorder risks.Approach psychedelics cautiously during postpartum due to potential anxiety increases and offspring effects via milk.Recognize hormonal shifts heighten sensitivity to infant cues, aiding natural caregiving instincts.Monitor environmental factors like food availability or threats that could disrupt parental behaviors in high-stress scenarios.About the guest: Danielle Stolzenberg, PhD is an associate professor of psychology at the University of California, Davis, where her lab studies the neurobiology of maternal care.Reference Paper:Study: Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspringRelated Episode:Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Judson and his husband host an engagement/tree-trimming/Shabbat celebration with a Halloween theme. Brian and Judson's husband have a clandestine meeting without them. Brian thinks he may have come out to his mother about his open marriage. A listener provides some important context around the use of SSRIs. The Hookup of the Week comes from a listener sharing a favorite memory of some public group sex that took him by surprise. They are then joined by actor, comedian and writer Aaron Jackson. Aaron talks about his role as “social justice warrior, but for Instagram” Caden Smucker in Drew Droege's Messy White Gays currently running off-Broadway, how the role is a departure of sorts for him and his journey from theatre school to improv comedy back to acting. He also shares the origin and process of writing his spectacular novel, The Astonishing Life of August March, discusses his longstanding working relationship with prior Dads and Daddies guest, Josh Sharp and their experience as some of the few gay members of Upright Citizens Brigade when they joined.  Other topics covered include whether or not Aaron and his college sweetheart husband could be part of a throuple, his skills in the kitchen, why he christened himself as a “Garbage Troll” on Instagram, and his hatred of completing forms. To close, Aaron helps Brian and Judson respond to a listener's two-part question asking whether or not he is watching too much porn, and for advice on what to do when one looks like a daddy but wants to be a son. Find Aaron Jackson on Instagram https://www.instagram.com/garbagetroll Email your Hookup of the Week, Go Ask Your Dad and Dr. Daddy submissions to dadsanddaddies@gmail.com Dads and Daddies on the Web: https://www.dadsanddaddies.com/ Dads and Daddies on Instagram: https://www.instagram.com/dadsanddaddiespod Dads and Daddies on TikTok: https://www.tiktok.com/@dadsanddaddiespod Dads and Daddies on Bluesky: https://bsky.app/profile/dadsanddaddiespod.bsky.social Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Do SSRIs help your brain?SSRI medications are among the most widely prescribed antidepressants, but what if we've misunderstood how they work? In this interview, Dr. Bret Scher sits down with biochemist and nutrition scientist Dr. Chris Masterjohn to explore a deeper, more systemic view of mental health and how we treat it.Dr. Masterjohn reveals why serotonin isn't just a “mood booster,” how SSRIs may be disrupting mitochondrial function, and why focusing on lifestyle strategies that support brain energy metabolism could unlock new paths for treating depression.

This week on Health Matters, we're sharing an episode of NewYork-Presbyterian's Advances in Care, a show for listeners who want to stay at the forefront of the latest medical innovations and research. On this episode of Advances in Care, host Erin Welsh first hears from Dr. Richard Friedman, a clinical psychiatrist at NewYork-Presbyterian and Director of the Psychopharmacology Clinic at Weill Cornell Medicine. Using his background in psychopharmacology, Dr. Friedman distinguishes between psychedelics and standard antidepressants like SSRIs and SNRIs, explaining the various mechanisms in the brain that respond uniquely to psychedelic compounds. Dr. Friedman also identifies that the challenge of proving efficacy of psychedelic therapy lies in the question of how to design a clinical trial that gives patients a convincing placebo. To learn more about the challenges of trial design, Erin also speaks to Dr. David Hellerstein, a research psychiatrist at NewYork-Presbyterian and Columbia. Dr. Hellerstein contributed to a 2022 trial of synthetic psilocybin in patients with treatment resistant depression. He and his colleagues took a unique approach to dosing patients so that they could better understand the response rates of patients who use psychedelic therapy. The results of that trial underscore an emerging pattern in the field of psychiatry – that while psychedelic therapy has its risks, it's also a promising alternative treatment for countless psychiatric disorders. Dr. Hellerstein also shares more about the future of clinical research on psychedelic therapies to potentially treat a range of mental health disorders.***Dr. Richard Friedman is a professor of clinical psychiatry and is actively involved in clinical research of mood disorders. In particular, he is involved in several ongoing randomized clinical trials of both approved and investigational drugs for the treatment of major depression, chronic depression, and dysthymia.Dr. David J. Hellerstein directs the Depression Evaluation Service at Columbia University Department of Psychiatry, which conducts studies on the medication and psychotherapy treatment of conditions including major depression, chronic depression, and bipolar disorder.___Health Matters is your weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine.To learn more visit: https://healthmatters.nyp.org

On today's episode, Dr. Mark Costes is joined by his good friend and fellow Black Belt Coach, Dr. Taher Dhoon—co-founder of the Colorado Surgical Institute and owner of an 18-operatory dental practice—for a deep dive into implant complications. They kick things off with a candid conversation on time management, shiny object syndrome, and how to balance business success with family life and fulfillment. Dr. Dhoon shares the systems he uses to juggle clinical days, content creation, and high-level strategy, including his cleverly titled "Get Your Sh*t Done" days.   From there, they dive into the nitty-gritty of implant surgery complications—from the importance of case selection and managing patient expectations, to specific pre-op protocols like vitamin D, antibiotic regimens, and why SSRIs and bisphosphonates need extra attention. Dr. Dhoon also outlines his intraoperative strategies for preventing failures, such as the 50/50 drilling technique and why 45 Ncm of torque should be your new standard. The episode wraps with a practical post-op game plan for soft tissue management, follow-up protocols, and how to handle setbacks with confidence and composure. This conversation is a masterclass in surgical systems thinking, built from years of real-world experience. Be sure to check out the full episode from the Dentalpreneur Podcast! EPISODE RESOURCES Dr. Taher Dhoon – (858) 692-3533‬ Chris Richards – (970) 420-6148‬ https://www.truedentalsuccess.com Dental Success Network Subscribe to The Dentalpreneur Podcast

Allie interviews Dr. Josef Witt-Doerring, a psychiatrist and former FDA drug safety officer. He unveils the truth about Big Pharma and the detrimental side effects of medications for mental illnesses. SSRIs cause more harm than good; they blunt emotions, breed dependency, and often backfire long-term. Dr. Witt-Doerring advises patients to pursue holistic health that includes a balanced diet, sleep, exercise, and therapy. He and his wife have started TaperClinic, where they help people come off medications and find real solutions to their problems. Join us for an eye-opening discussion about the dark side of the pharmaceutical industry. Check out more about Dr. Witt-Doerring's TaperClinic here: ⁠taperclinic.com⁠ Buy Allie's book "Toxic Empathy: How Progressives Exploit Christian Compassion": ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.toxicempathy.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Timecodes: (00:00) Intro (09:45) Misdiagnosing Mental Illness (19:20) Drug Safety Officer (25:05) Corruption in Medical Academia (27:50) Wake-Up Call (34:35) Problems with SSRIs (46:00) Short-Term vs. Long-Term Medication (53:50) TaperClinic --- Today's Sponsors: PreBorn — Would you consider a gift to save babies in a big way? Your gift will be used to save countless babies for years to come. To donate, dial #250 and say the keyword BABY or donate securely at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠preborn.com/allie⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Good Ranchers — Give a reason to gather. Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠goodranchers.com⁠⁠⁠⁠⁠⁠⁠⁠⁠ to start gifting, and while you're there, treat yourself with your own subscription to America's best meat. And when you use the code ALLIE, you'll get $40 off your first order. EveryLife — Visit ⁠⁠⁠⁠⁠everylife.com⁠⁠⁠⁠⁠ and use promo code ALLIE10 to get 10% off your first order today!  Patriot Mobile — Switching to Patriot Mobile is easier than ever. Activate in minutes from your home or office. Keep your number, keep your phone, or upgrade. Go to ⁠⁠⁠patriotmobile.com/allie⁠⁠⁠ or call 972-PATRIOT, and use promo code ALLIE for a free month of service! Cozy Earth — Give the gift of everyday luxury this holiday season. Head to ⁠cozyearth.com⁠ and use the code RELATABLE for up to 40% off — just be sure to place your order by December 12 for guaranteed Christmas delivery. --- Episodes you might like:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Ep 1189 | SSRIs Are Rewiring Babies' Brains — and Killing Their Moms | Guest: Dr. Adam Urato ⁠https://podcasts.apple.com/us/podcast/ep-1189-ssris-are-rewiring-babies-brains-and-killing/id1359249098?i=1000708507649⁠ Ep 821 | Why Antidepressants Don't Fix Depression | Guest: Dr. Roger McFillin ⁠⁠https://podcasts.apple.com/us/podcast/ep-821-why-antidepressants-dont-fix-depression-guest/id1359249098?i=1000616890403⁠⁠ Ep 822 | The Big Money Behind Big Medicine | Guest: Dr. Roger McFillin ⁠⁠https://podcasts.apple.com/us/podcast/ep-822-the-big-money-behind-big-medicine-guest-dr/id1359249098?i=1000617050991⁠⁠ Ep 1031 | Psychiatry Is Killing People | Guest: Dr. Roger McFillin ⁠⁠https://podcasts.apple.com/us/podcast/ep-1031-psychiatry-is-killing-people-guest-dr-roger/id1359249098?i=1000661830317⁠⁠ --- Buy Allie's book "You're Not Enough (and That's Okay): Escaping the Toxic Culture of Self-Love": ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.alliebethstuckey.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Relatable merchandise: Use promo code ALLIE10 for a discount: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://shop.blazemedia.com/collections/allie-stuckey⁠⁠⁠⁠⁠⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

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Week four of the Ending Well series lands right at the halfway mark. This episode is a look back over a three-year road (starting in 2022) of how God helped me fight inflammation, feel like myself again, and regain my "glow." This is not a weight-loss talk, not a quick-fix list, and not medical advice. It's a redemption story about healing from the inside out — spiritually, emotionally, and physically. "Beloved, I pray that you may prosper in all things and be in health, just as your soul prospers." — 3 John 1:2 Key Themes Redemption doesn't just cover salvation; it keeps working through sanctification and healing. Inflammation wasn't just a food problem — it was also a soul and nervous system problem. Real health change is slow, layered, and personal. Your timeline will not look like mine. The glow came as a byproduct of feeling better and living freer, not chasing beauty. Important Disclaimers This episode is descriptive, not prescriptive. Not medical advice. Always talk with a qualified professional for your situation. Do not try to do everything at once. This was a year of foundations plus a total three-year process. One percent better beats perfect overnight. The Story: How the Dominoes Fell 1. August 2022: Stepping Back From Fear-Driven "Crunchy" Culture I was drowning in rules, guilt, and constant fear of what might be harming me. The anxiety and striving became more toxic than the ingredients I was avoiding. First domino: I quit trying to do it all perfectly and started living with grace, budget reality, and peace. Lowering my standards for myself lowered my inflammation. "Come to me, all who are weary and burdened, and I will give you rest." — Matthew 11:28 2. October 2022: A Major Boundary With a Toxic Relationship I set a serious boundary with someone whose presence fueled self-hatred. Went no contact for about six months. The inner tape of shame and criticism began to quiet. I learned that giving up self-hatred is profoundly anti-inflammatory. Recommended resource mentioned: When to Walk Away by Gary Thomas (plus podcast interview) "Guard your heart above all else, for it determines the course of your life." — Proverbs 4:23 3. Early 2023: Changing How I Worked Out I stopped high-intensity workouts that were spiking cortisol daily. Switched to lifting heavy and slow, more functional strength training. Worked out less, recovered more. Energy improved, inflammation eased, confidence rose. Current favorite: Nourish Move Love workouts on YouTube. Big takeaway: exercise is a gift, not punishment. 4. February to May 2023: Going Gluten-Free and Cutting Back on Alcohol Grain Brain by Dr. David Perlmutter was a turning point. I tried going gluten-free (cold turkey, not ideal but it worked). Brain fog cleared, bloat dropped, inflammation noticeably reduced. Cutting alcohol alongside gluten made a huge difference. I don't need to understand every mechanism to honor what clearly helps my body. Reminder: everyone has a "thing" — gluten, dairy, sugar, alcohol, stress. Find yours with grace. 5. August 2023: Getting Off SSRIs After 15 Years A massive milestone with a full story in episode 267. For me, SSRIs were not helping inflammation or overall vitality anymore. The drop in facial inflammation from August to December was dramatic. I'm not shaming anyone on SSRIs — I was on them a long time. This was my path. "It is for freedom that Christ has set us free." — Galatians 5:1 What Actually Healed Me This part matters: the glow wasn't mainly from products. Lowering impossible expectations Creating boundaries Learning to like myself Getting out of fight-or-flight Moving my body in a gentler way Removing gluten and minimizing alcohol Walking in obedience even when it felt backwards Healing was spiritual and emotional first, physical second. "Be transformed by the renewing of your mind." — Romans 12:2 Simple "Glow Back" Skin Habits These are the practical, easy wins that helped the outside catch up to the inside. Dermaplaning at home Removes dead skin and peach fuzz. Skin care and makeup apply better. Big difference in glow and smoothness. Learn carefully through YouTube tutorials and use a quality razor. Stopping skin picking Picking was aggravating redness and irritation. I prayed about it and replaced the habit. New habit: brush my hair when the urge hits. Asking God for help in small things counts. Sponsor Spotlight: PreBorn A free ultrasound can double a mother's chance of choosing life. PreBorn offers ultrasounds plus ongoing support for mothers for up to two years. It costs 28 dollars to sponsor one ultrasound. Donate at preborn.com/speakeasy. Takeaways to Sit With If you're overwhelmed, start with one domino. God often heals from the root, not just the symptom. Your body listens to your beliefs. Peace, obedience, and self-kindness are deeply practical health tools. The goal isn't prettier; it's freer, healthier, and more whole. Reflective Questions What is one area where fear or perfectionism is inflaming your life? Who or what might need a boundary so you can heal? What small change feels like the next right step, not the whole staircase? How would your health shift if you treated yourself like someone God deeply loves? Closing Encouragement This glow-back story is really a "come back to life" story. It wasn't a sprint; it was obedience in baby steps. If you're in the thick of it today, don't despise the slow fade. God redeems years, bodies, minds, and hearts — and He's patient in the process. "He restores my soul." — Psalm 23:3

We know you're struggling. So we brought in the most soothing human on the planet-Therapy Jeff- to offer tips on how to get through Thanksgiving with your nasty family. In short, don't take the bait, find your family buddy, and if you are alone on the holiday, get yourself to a gay bar. Also, a woman who considers herself bad in bed wonders how she can find a "sex teacher." And, a woman wonders if she has her sub drink her pee while she is on SSRIs, will he ingest her meds? "Gobble" it up! Q@Savage.Love 206-302-2064 This episode is brought to you by Squarespace. They make it easy to build a website or blog. Give it a whirl at Squarespace.com/Savage and if you want to buy it, use the code Savage for a 10% off your first purchase. This episode is brought to you by Carafem, an abortion and reproductive healthcare provider that offers both in person care in Atlanta, Chicago, Washington DC and telehealth options for abortion pills by mail in 20 states. Carafem's team of licensed medical professionals provide personalized abortion care options focused on your needs, preferences, and values. Visit Carafem.org to learn more. This episode is brought to you by Feeld, a dating app where the open-minded can meet the like-minded. Download Feeld on the App Store or Google Play.

Antidepressants like SSRIs are strongly linked to hyponatremia, a dangerous drop in blood sodium that disrupts nerve and muscle function The risk is highest in the first two weeks of treatment, when sodium levels plummet to life-threatening lows that trigger confusion, seizures, or fainting Older adults, especially women over 80, are among the most vulnerable, with nearly 1 in 15 experiencing profound sodium loss after starting these drugs Symptoms of drug-induced low sodium often mimic worsening anxiety or depression, leading to misdiagnosis and unnecessary increases in medication Natural strategies like optimizing nutrition, restoring key vitamins and minerals, daily movement, sunlight exposure, and restful sleep offer safer ways to support mood and energy without creating sodium imbalances

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption. Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork. You'll Learn: • Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood • The exact signs that your dose is too strong, too weak, or in the Goldilocks zone • How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience • Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions • How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters • The link between mitochondrial health, fertility, libido, and long term anti aging strategies • How to track sleep optimization, HRV, and performance signals to dial in your personal protocol • The difference between aquarium grade dye and pharmaceutical grade formulations • Why genetic testing for G6PD deficiency is essential before higher dose experimentation Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair Thank you to our sponsors! -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 4:51 — History of methylene blue 7:38 — How methylene blue works 14:05 — Safety 17:53 — Dosing and timing guidelines 20:41 — Combining with red light therapy 22:41 — Quality and sourcing 23:17 — Dosing protocols 25:24 — Longevity and fertility effects 29:24 — Stacking options 32:10 — Common questions and FAQs 33:40 — Future research and wrap up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.