Podcasts about ssris

SSRI antidepressants are one of the most harmful medications on the market, and because of just how many people they are given to (often for no good reason as only a minority of patients benefit from SSRIs) they have had a profound effect on the consciousness of our entire society This article will review some of the more common side effects of SSRIs (and SNRIs), such as losing the ability to have sex, becoming numb to life, becoming severely agitated or imbalanced (sometimes to the point one becomes violently psychotic or commits suicide), losing your mind, and the development of birth defects Like many other stimulant drugs (e.g., cocaine) SSRIs can be very difficult to quit. Because of this, patients frequently get severely ill when they attempt to stop them (withdrawals affect roughly half of SSRI users). Worse still, it is often extremely difficult to withdraw from them and very few doctors know how to safely facilitate this Due to widespread denial in psychiatry about the issues with their drugs the common SSRI side effects (e.g., withdrawals) are often misinterpreted as a sign the individual had a pre-existing mental illness and needs more of the drug — which all too often then leads to catastrophic events for the over-medicated patient This article will provide the critical information SSRI patients are rarely warned about and resources for patients already trapped in challenging mental health situations  

Dr. Joanna Moncrieff is a British psychiatrist and author of “Chemically Imbalanced: The Making and Unmaking of the Serotonin Myth.” She challenges the long-held belief that depression is caused by a lack of the hormone serotonin.“The serotonin myth … was first put out there in the 1960s, then picked up by the pharmaceutical industry in the 1990s and widely propagated by them as part of their campaign to sell SSRIs, their new generation of antidepressants,” she said.Contrary to what many people still believe, there's no evidence that depression is caused by a lack of serotonin in the brain, Moncrieff said.“A few years ago, we published what's called an umbrella review, a sort of meta review of all the different areas of research that have looked at this. … And we show that there is no consistent or convincing evidence in any of these areas of research for any association between serotonin and depression. So hence, the idea is a myth,” she said.In our interview, she explains how this narrative took hold and how it reshaped modern psychiatry.So what causes depression if not a lack of serotonin? Dr. Moncrieff, who is a professor of critical and social psychiatry at University College London, regards depression as “meaningful human reactions to the circumstances of life now, and that is indeed how people used to think about them.”It's not a biological disease, she said, but a normal reaction that anyone may experience at times throughout life.“It's not something that we naturally just get over in a couple of weeks. It can take weeks and months of grieving, even for a short-term relationship that's finished.”To label deep sadness as a pathological medical condition that needs to be fixed with drugs is the wrong approach and precludes seeing a person “who is suffering, who is going through a period of difficulty and trying to work out what that is and how we can support them with it,” Moncrieff said.Views expressed in this video are opinions of the host and the guest, and do not necessarily reflect the views of The Epoch Times.

Three facts are scientifically undisputed: Serotonin is essential for fetal brain development. SSRIs disrupt the serotonin system. SSRIs freely cross the placenta. So why are pregnant women being told these drugs carry "little or no risk"?In this rare head-to-head debate, Dr. Adam Urato—maternal-fetal medicine specialist and FDA expert panelist—faces off against Dr. Robert Chen, a psychiatry resident willing to do what most of his colleagues won't: step into the arena and defend the establishment position.What unfolds is a striking conversation where both physicians actually agree on more than you'd expect—including that informed consent is failing pregnant women, that the chemical imbalance theory is dead, and that "untreated depression" is a misleading frame designed to sell drugs. The uncomfortable question neither side can fully answer: If SSRIs are correcting depression, why does the research show worse outcomes for women who stay on them?This isn't anti-medication propaganda. It's the conversation your doctor isn't trained to have with you.Listen before you fill that prescription. Visit Center for Integrated Behavioral HealthDr. Roger McFillin / Radically Genuine WebsiteYouTube @RadicallyGenuineDr. Roger McFillin (@DrMcFillin) / XSubstack | Radically Genuine | Dr. Roger McFillinInstagram @radicallygenuineContact Radically GenuineConscious Clinician CollectivePLEASE SUPPORT OUR PARTNERS15% Off Pure Spectrum CBD (Code: RadicallyGenuine)10% off Lovetuner click here

As 2026 gets underway we know that many take time around this new beginning to improve not only their physical, but also their mental health. With that in mind, we're rerunning an episode with Leanne Williams on the future of depression care. Leanne is an expert on clinical depression and is working on new ways to more precisely diagnose depression in order to develop more effective treatment. For anyone who has suffered from depression or knows someone who has, it's an episode that provides hope for what's on the horizon. We hope you'll take another listen and also share this episode with anyone who you think may benefit from the conversation. Episode Reference Links:Stanford Profile: Leanne WilliamsConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Leanne Williams, a professor of Psychiatry and Behavioral Science at Stanford University.(00:01:43) What Is Depression?Distinguishing clinical depression from everyday sadness.(00:03:31) Current Depression Treatment ChallengesThe trial-and-error of traditional depression treatments and their timelines.(00:06:16) Brain Mapping and Circuit DysfunctionsAdvanced imaging techniques and their role in understanding depression.(00:09:03) Diagnosing with Brain ImagingHow brain imaging can complement traditional diagnostic methods in psychiatry.(00:10:22) Depression BiotypesIdentifying six distinct biotypes of depression through brain imaging.(00:12:31) Cognitive Features of DepressionHow cognitive impairment plays a major role in certain depression biotypes.(00:14:11) Matching Treatments to BiotypesFinding appropriate treatments sooner using brain-based diagnostics.(00:15:38) Expanding Treatment OptionsPersonalizing therapies and improving treatment outcomes based on biotypes.(00:19:03) AI in Depression TreatmentUsing AI to refine biotypes and predict treatment outcomes with greater accuracy.(00:22:15) Psychedelics in Depression TreatmentThe potential for psychedelic drugs to target specific biotypes of depression.(00:23:46) Expanding the Biotypes FrameworkIntegrating multimodal approaches into the biotype framework.(00:27:29) Reducing Stigma in DepressionHow showing patients their brain imaging results reduces self-blame and stigma.(00:29:38) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The anti-ICE protests, sparked by the fatal shooting of Renee Good, presently happening throughout the USA, don’t appear to be dying down. So why does it appear to be mostly white women protesting? There are several theories as to why that is, but one is that a lot of these women are unmarried and childless but still have the instinct to mother, so they see ICE agents as their ex-husbands and the illegal immigrants as the children they don’t have. Plus, they’re sick and thus overly medicated on a chemical cocktail of antidepressants and SSRIs. The ICE agents are there to do their job, which is to enforce the law, and process warrants for people who are in the country illegally. So why are so many white women angry about it? Listeners certainly have their opinions about why this is. Meanwhile, what’s with all the whistles?See omnystudio.com/listener for privacy information.

Dr. Keith Humphreys is a professor of psychiatry and behavioral sciences at Stanford School of Medicine and a leading expert on treating addictions, drug laws and policy. We discuss all the major addictive substances and behaviors, including alcohol, opioids, gambling, stimulants, nicotine, cannabis and more, focusing on how genetics and certain use patterns shape addiction susceptibility. We discuss the best evidence-based tools for recovery, from 12-step programs to emerging treatments such as psychedelics and ibogaine. Anyone interested in making better choices for their health and/or seeking to avoid or overcome addictions ought to benefit from this episode. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:58) Keith Humphreys (00:03:22) Addiction; Genetic Risk (00:09:14) Alcohol Use Disorder & Alcoholism; Genetic Predisposition & Addiction Risk (00:18:03) Sponsors: David & BetterHelp (00:20:37) Women & Alcohol Use; Young Adults; Cannabis Use (00:23:36) Health Benefit to Alcohol?, Red Wine, Cancer Risk; Social Pressure (00:31:47) Alcohol in Social Gatherings, Social Anxiety, Vulnerability, Work & Dates (00:37:41) Old vs New Cannabis & THC Levels; Smoked vs Edible Forms (00:44:38) Cannabis & Psychosis Risk; Cardiac Health; Youth Cannabis Use & Transition to Adulthood (00:52:29) Sponsor: AG1 (00:54:13) Industries of Addiction, Regulation; Gambling, Slot Machines, Novelty; Casinos (01:05:28) Decriminalization vs Legalization; Cannabis, Gateway Drug? (01:08:50) Psylocibin or LSD, Addiction Treatment; Microdosing, Clinical Trial Challenges (01:18:58) Sponsor: Helix Sleep (01:20:32) Brain Plasticity & Age; Ketamine, Depression, Transcranial Magnetic Stimulation (TMS) (01:28:10) SSRIs, Mass Shootings, Suicide, Side Effects; Drug Approval; Ibogaine & PTSD (01:36:10) Caffeine Addiction?; Stimulants & Rehab; Prescription Stimulants & ADHD (01:44:04) Nicotine, Mistaking Withdrawal for Benefit (01:47:24) Sponsor: LMNT (01:48:44) Tool: How to Talk to Someone with Addiction (01:55:23) Perception of Addicts, Character Defect, Pain (02:00:58) Overcoming Addiction, Immediate Rewards, AA; Addict & Co-Dependency? (02:09:53) Longterm Drug Use, Dopamine, Cues & Relapse; Social Media (02:16:21) Brain Stimulation, TMS; Homelessness, Substance Use & Rehab (02:26:11) Addiction Treatment Policy, Rehab & Insurance (02:29:08) Tool: 12-Step Programs, AA, Accessibility & Benefits (02:38:08) AA, Higher Power, Cult?; Flexibility, Tool: Open AA Meetings (02:44:38) GLP-1s, Weight Loss, Alcohol Addiction; Pharmaceutical Advertisements (02:52:39) Social Media Addiction, Tool: Avoiding Social Media Strategies (02:58:36) “Failure to Launch”, Youth, Video Games, Social Media; Recovery Pathways (03:04:13) AA as an Action Program, Tool: Try Different AA Meetings (03:08:21) Hospice, Death, Overcoming Fear of Death (03:13:54) Addiction to Escape Death?, Desire for Oblivion (03:18:11) Men vs Women & Addiction; Lying; Relapse; Fentanyl & Addiction Advice (03:24:27) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Contributor: Taylor Lynch, MD Educational Pearls: What is tramadol and how does it work? Tramadol is a Schedule IV opioid analgesic used for moderate pain and is often perceived as safer than other opioids due to lower abuse potential. It is a prodrug with weak direct μ-opioid receptor activity. The parent compound also inhibits serotonin and norepinephrine reuptake, giving it SSRI/SNRI-like properties. Tramadol is metabolized by CYP2D6 into O-desmethyltramadol (ODT), which has significantly stronger μ-opioid receptor agonism than the parent drug. What are the concerns with tramadol? Ultrarapid CYP2D6 metabolizers (more common in Middle Eastern and North African populations) rapidly convert tramadol to ODT, increasing the risk of opioid toxicity. Poor CYP2D6 metabolizers generate little ODT and may experience primarily serotonergic effects, increasing the risk of serotonin syndrome, especially when combined with SSRIs or SNRIs. CYP2D6 inhibitors (e.g., bupropion, paroxetine, terbinafine, celecoxib) can block tramadol's conversion to ODT, potentially precipitating opioid withdrawal or increasing serotonergic toxicity. Tramadol is also associated with an increased risk of first-time seizures, even at therapeutic doses. Key takeaways Tramadol's effects are highly unpredictable, varying from minimal analgesia to exaggerated opioid effects depending on metabolism. Drug–drug interactions can lead to serotonin syndrome or opioid withdrawal. Despite its Schedule IV classification and reputation for safety, alternative analgesics may be preferable in many patients. References DailyMed - TRAMADOL HYDROCHLORIDE tablet, coated. Accessed January 10, 2026. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=61fb5ba7-6896-4ee4-83de-caee69b06a8e#ID57 Dean L, Kane M. Tramadol Therapy and CYP2D6 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, eds. Medical Genetics Summaries. National Center for Biotechnology Information (US); 2012. Accessed January 10, 2026. http://www.ncbi.nlm.nih.gov/books/NBK315950/ Aly SM, Tartar O, Sabaouni N, Hennart B, Gaulier JM, Allorge D. Tramadol-Related Deaths: Genetic Analysis in Relation to Metabolic Ratios. J Anal Toxicol. 2022;46(7):791-796. doi:10.1093/jat/bkab096 Summarized and edited by Dan Orbidan OMS2 Donate: https://emergencymedicalminute.org/donate/ Join our mailing list: http://eepurl.com/c9ouHf  

Dementia is often a highly burdensome disease process for patients, their caregivers and families, and the community at large. Palliating symptoms and providing guidance surrounding advance care planning and prognostication are integral components of the management plan. In this episode, Katie Grouse, MD, FAAN, speaks with Neal Weisbrod, MD, an author of the article "Neuropalliative Care in Dementia" in the Continuum® December 2025 Neuropalliative Care issue. Dr. Grouse is a Continuum® Audio interviewer and a clinical assistant professor at the University of California San Francisco in San Francisco, California. Dr. Weisbrod is a neurologist at Hartford Healthcare with the Ayer Neuroscience Institute in Mystic, Conneticut. Additional Resources Read the article: Neuropalliative Care in Dementia Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Grouse: This is Dr Katie Grouse. Today I'm interviewing Dr Neal Weisbrod about his article on neuropalliative care in dementia, which appears in the December 2025 Continuum issue on neuropalliative care. Welcome to the podcast, and please introduce yourself to our audience.  Dr Weisbrod: Thank you. I'm really excited to be here. I'm Neal Weisbrod. I'm a neurologist and palliative care physician currently working at Hartford Healthcare in Mystic, Connecticut. Dr Grouse: To start, I'd like to ask why you think it's important that neurologists read your article? Dr Weisbrod: The primary reason I think it's really important to read the article is because these are just really common problems that neurologists run into in clinical practice. So, Alzheimer disease and many other dementias are extremely common, and managing the burdensome symptoms and the complex discussions that we have to have with the patients and their families as they go through the course of dementia is something that is very common in clinical practice. And so my hope is that by reading this article, clinicians will pick up a few tools, a few new ideas for how to make these conversations easier and for how to help these patients get through the disease with a little bit less suffering. Dr Grouse: I learned a lot from reading your article, and I really encourage our listeners to check it out. But I was curious what you feel that you discussing your article would come as the biggest surprise to our listeners? Dr Weisbrod: So, I think that the most surprising thing a lot of people will see reading this article is the section on prognosis. A lot of times it seems families are counseled, when they're talking about the prognosis of Alzheimer disease, that it could be ten years or longer. But really, the data show that for many patients, the median prognosis is closer to three to eight years. And that is a little bit longer for Alzheimer disease than many other types of dementia, but also gets significantly shorter as patients get older. So, we're looking at a closer to three-year median prognosis for patients who are over eighty-five, whereas patients in their sixties are probably closer to the eight or nine-year median prognosis. And so I think that piece will hopefully help people give a little bit more accurate counseling about prognosis.  Dr Grouse: I'm glad you brought that up because I was wondering, why is it so important that we are careful to make sure that we're giving prognostic information for our patients and maybe even updating it as their clinical status changes? Dr Weisbrod: I think first of all, it's a really common thing that patients and families are thinking about and worried about. They don't necessarily always seem to ask as much as they want to know. I think there's a lot of fear around that conversation, even though it's really important. And then there's also often tension between the family and caregivers tend to want to know more than patients do. I think that it really helps people plan for the future as well as possible to know what their future might be. And we have a lot of limitations in predicting the future, but using the best information we can, laying out what we think the likely range is, allows people to make a lot more clear plans for their future. Dr Grouse: I'd imagine it's also pretty helpful for hospice referrals, too, having that data.  Dr Weisbrod: Yeah, definitely. And there's a lot of angst about when to refer patients who have dementia to hospice. The most important thing I think about when I'm making a hospice referral is that I don't have to be right. And I think it takes a lot of that concern off to just say, all I'm doing is making a connection, getting someone who's potentially interested in the hospice, who has a really advanced serious illness connected to a hospice agency. And then they can go through the full evaluation with the hospice and the hospice medical director and determine whether they're eligible. So, I think there are really helpful thresholds to think about that would be a good trigger. Like a patient who we think has advanced dementia, who has a hospitalization for pneumonia or a fracture of the hip or some other really serious acute medical condition, I think is a really good trigger to start to think about hospice. But most importantly, it's just the connection, and I tell the patients that upfront. I tell them that you're going to have a conversation and we'll decide whether you're a good fit, and if not, the hospice will usually just check in with you over time and decide when is the right time in the future. Dr Grouse: That's really helpful. And I think just a really great reminder to our listeners about thinking about hospice sooner or at certain critical points in their patient care rather than waiting, maybe, before it's gone on too long and may be of less use later on. I was wondering, in your own clinical practice, what do you think is the most challenging aspect of providing care to patients with dementia?  Dr Weisbrod: I think this one's easy. I would say managing the time has to be the most difficult part. I think that taking care of patients who have dementia is time-consuming. There's a lot of different priorities that we have to manage the time around. How much time are we going to spend doing cognitive testing? How much time are we going to spend doing counseling? How much time are we going to spend making up a treatment plan and discussing medications? How much time are we going to spend on advanced care planning? And the way I try to combat that is really just trying to think about what I'm going to prioritize in a certain visit and not try to accomplish everything. I'll tell patients and their families, the next time you come in, we're going to have a conversation focusing on advanced care planning. Or, the next time you come in, we're going to sit down and try to talk through all the questions you have about what the future might hold. That way I in that visit, I don't feel like, oh, I have to do updated cognitive testing and I have to review all the next steps in medication, and that allows me to take it in more bite-sized chunks. Dr Grouse: You made some of the great points, and specifically you mentioned advanced care planning. Your article makes a really strong case for the importance of advanced care planning, yet you definitely acknowledge the many barriers to initiating discussions that clinicians face. In your patients with dementia, can you walk us through how you integrate discussions about advanced care planning with your patients and their families?  Dr Weisbrod: Yeah, I think this is still something that is evolving in my practice, and I don't think there's any perfect way of doing it. I think there's a lot of right ways of doing it, and as long as we're thinking about it a lot and bringing it up periodically, that's probably the best. What I try to do, though, is after I discuss what I think is the most likely diagnosis with patients and their families, I try to have a fairly close follow-up visit after that. Allow them to digest that information, to often do a little bit of their own research, to talk about it as a family. And then when they come in for that next appointment, I try to at least lay some groundwork about advanced care planning, asking them what they've completed already, and then based on what they've already done to that point, talking to them about what I think the next step would be. If they have done nothing, usually it's just, hey, I really think you should start to think about who would be making decisions for you if you lose the ability to make your own decisions and counsel them about power of attorney paperwork and establishing a healthcare surrogate. When it's patients who have already done some of that initial prep, I think that it's really important to keep in mind it's a longitudinal discussion and you can take it in small pieces over time. Often that helps because you can really establish that rapport and that trust. And then I like to just keep checking in whenever there's major changes in the patient's health or condition, like admission to the hospital or transfer to an assisted living facility or memory care clinic. Those are good times to remember, hey, I really need to revisit this conversation.  Dr Grouse: It's probably good to also mention another really important point from your article, which was that impairment of decision-making in patients with dementia can actually start significantly even in the phase of mild cognitive impairment. Yet these patients will need to make many medical decisions with their neurologist as they go through this journey. How can we make sure our patients have capacity and make decisions appropriately regarding their care? Dr Weisbrod: Yeah, I think that's a definite challenge of taking care of patients with cognitive disorders of any type, including those with stroke and multiple sclerosis, that have some cognitive impairment. In my opinion, the most important way to help manage that is to make sure when we are making important decisions about the future that we're having a deep exploration of the values and the reasoning behind that. And definitely teach back is the most helpful way that I use to explore those values and the logic behind patients' decisions. So, I think we have to have a really low threshold to move on to a formal evaluation of capacity; if there's any inconsistency between what the patient's saying now and what their families say they've said in the past, or if they're having struggled to come up with a really clear logic behind their decision, then I think we have to have a low threshold to move on to a formal evaluation of capacity. So, I think having the family involved, having other people who know the patient really well, usually helps identify some of those periods where it seems like the patient's not making the decision that really reflects their true wishes. Dr Grouse: Now I wanted to switch gears a little bit and get into the management of neuropsychiatric symptoms, which you spend a lot of time on and I think a lot of neurologists find very challenging. What are some nonpharmacologic approaches that can help patients with significant neuropsychiatric symptoms?  Dr Weisbrod: I really like the DICE paradigm for coming up with nonpharmacologic approaches. The DICE paradigm is an acronym. The D is Describe, I is Investigate, C is Create, and E is Evaluate. The idea is that we're exploring what's happening behind the symptoms, we're creating a plan to intervene, and then we're evaluating the outcome of that plan and creating a sort of feedback loop there. But ultimately, I think, when we're creating a solution, thinking about how we can change the environment is the most important thing. We have very limited ability to change the way that someone who has severe cognitive dysfunction reacts to their environment, but we can often change the environment to not produce that reaction in the first place. One example is with wandering behaviors. Trying to change the environment where you put locks that don't have deadbolts that you can use on the inside of the house, you have to have a key on the inside of the house, and then the family can put that key somewhere safe where the patient is not likely to find it and be able to unlock the door and wander out unsafely. I also think it's really important to acknowledge that as doctors, we are maybe not the best people to always have the answer when it comes to changing a patient's environment. And so, I think we really need to rely on the wisdom of support groups and other people who are going through the challenge of dementia. Our interdisciplinary care teams like social workers and nurses who have experience in managing dementia, and really try to plug the caregivers into as many of these avenues as possible so that they can learn from all of that community of wealth and not always rely on the doctor to have the answer. Dr Grouse: Switching gears to pharmacologic management, which is a lot of what we do for patients as neurologists. Thinking about agitation, pharmacologic management of agitation can be very challenging. And reading your article, it reminds me how disheartening it is to reflect and how modest the effect of the available options are, along with the many potential risks of their use, When nonpharmacologic interventions fail, what should neurologists recommend for their patients with agitation? Dr Weisbrod: Yeah, I definitely agree. It's every time I go back and look at this literature and look at what's new, it is a bit disheartening. But even in the face of all that, I really feel like SSRIs are my first-line therapy for most of these patients. I always try to ask myself what might be causing the patient discomfort that they are then manifesting as agitation because they don't have a better way of expressing themselves. Often, I feel like that's anxiety or depression or some other psychological symptom that we might be able to address with an SSRI. So, I tend to use sertraline and escitalopram, start those early and as long as patients are tolerating it, give it a really good trial. Outside of that, escalating to other pharmacologic approaches, even though there's such controversy in the data about antipsychotics and even though there are very real risks, sometimes I think we essentially do need a chemical sedative. And I think that it's important to have a very frank conversation upfront with the caregivers and the medical decision maker for that patient. Make sure we are counseling them on the risk, the increased risk of mortality, and also to make it a time-limited trial. So, I think that saying we're going to try this medication (if the patient's decision maker agrees, obviously) for a month or two months or three months. But I definitely wouldn't want them to just have an open-ended plan where they're going to stay on it indefinitely. It should have some end point where we say, hey, is this working or not? And if it's working, then we'd make a decision, is the improvement in quality of life worth the risks? And if we're not seeing that improvement, then we definitely need to stop it. Dr Grouse: That seems very reasonable. And then thinking more towards some of the other types of symptoms that can be really challenging, I was really surprised to see how often uncontrolled pain is a significant contributor in patients with dementia. And certainly, both uncontrolled pain and poor sleep can worsen cognitive function and neuropsychiatric symptoms in general. But of course, there's ongoing concerns about side effects of these therapies and how they can also potentially worsen things. How should we be approaching management of pain and insomnia or poor sleep in these patients?  Dr Weisbrod: I think the key is just to start with really low burden treatments and escalate carefully and start with low doses of higher risk medications. So, when I think the low burden treatments for pain, scheduling acetaminophen, 1000 milligrams every eight hours, seems like a trivial thing to do, maybe? But it's actually surprising how much scheduled acetaminophen can take the edge off of pain and might be able to avoid some of these flare-ups of neuropsychiatric symptoms, may be able to really improve that pain a little bit. I do think it really has to be scheduled, though. Trying to rely on patients who have significant cognitive dysfunction to use a PRN medication is going to lead to a lot of problems and undertreatment. And then on the sleep disorder side, I think starting with low-dose Trazodone and gradually increasing the dose of Trazodone as a really safe way of initially approaching the insomnia. And then only when it's a more refractory case do I reach for the high-risk medications. Like for pain, we're talking about opiates. I think there's a lot of very reasonable concern about using opioids in patients who have cognitive dysfunction. But if there is a really good reason to think that they have severe pain, like they have a past pain disorder, I think that just like with antipsychotics, there are definitely real risks to these medications. But at the end of the day, if we are improving someone's quality of life dramatically and the patient's medical decision maker is willing to take on those risks, then we're really doing the patients a favor. Dr Grouse: Now, another issue that you mentioned in your article, which I see a lot and often struggle with myself, is how and when to deprescribe certain types of medications such as cholinesterase inhibitors and memantine. Any tips or tricks to how to approach this?  Dr Weisbrod: My approach to this has also evolved a bit over the years. The new data that cholinesterase inhibitors may have a mortality benefit in patients with Alzheimer disease has changed my thinking a little bit. But there are still lots of situations where it's just too burdensome or patients seem to be having side effects. And so, I think about deprescribing. The most important thing in my mind is really thorough counseling before deprescribing with the patient's family and medical decision maker. I think that letting them know that we might actually be holding things more stable with the medication than we realize, there could be a flare-up, that we can resume the medication if that flare-up happens but we don't always guarantee getting back to the same point. I think having that conversation ahead of time will ward off some of the worst issues that you have afterwards. And then I think doing a taper of cholinesterase inhibitors over two weeks to a month is probably the most prudent because of some of the data about withdrawal and exacerbation of neuropsychiatric symptoms or cognitive worsening. Memantine, I think the data is a lot more shaky on withdrawal. And so, I think it's less important to gradually taper memantine. But I think that once again, just having the conversation upfront and letting the family know these are the things we have to look out for and these are the risks is going to be the most important. Dr Grouse: That's really helpful and a great strategy to take advantage of. Another, I think, really difficult topic that I wanted to ask you about was the discussion around nutrition and whether or not to consider putting in some type of a permanent tube for tube feeds. How do you approach that conversation? Certainly a difficult one.  Dr Weisbrod: Yeah, I think it's easily one of the most difficult conversations to have in the care of patients who have dementia. And there's so much emotion in the families when they're having this discussion. And I think really acknowledging there's a huge emotional piece of the conversation is one key piece. For families and caregivers, they're thinking, I don't want my loved one to starve to death. That's usually the most important thing in their mind. We have to address that concern in the conversation, or they're never going to get to a point of satisfaction with the decision that's being made. So, I think while there is still some controversy in the literature about artificial nutrition for patients who have dementia, the bulk of data indicates that it is not helpful for patients. It may exacerbate dementia, it leads to more restraint. And so, I think unless there's some reversible medical condition that we're just trying to do artificial nutrition to get them through, like, they have a stroke and we're expecting that their dysphasia is going to improve because of the stroke is going to heal. Those situations might be a good reason, but if we really think that the driving factor behind their dysphasia is their dementia, I think we should be guiding the families away from that. And I think that explaining that as dementia gets really advanced, the body is slowly shutting down. The body is not needing as much nutrition, and forcing more nutrition in has not been shown to help people who have dementia. Really putting it in that sort of language is going to help the families understand and be comfortable with that decision. I also think that it's really helpful to consider talking to families about what they can do and not have the entire conversation be about what we're not doing or not putting in a feeding tube for artificial nutrition. So, I think really good counseling about, we can do comfort feeding, we can expand what food we're giving the person who has dementia and really focus on foods that they really enjoy and not worry so much about the health and nutrition anymore. I think that focus on what they can take control of can also help make the decision easier for families.  Dr Grouse: I really like that approach. And I agree, it does seem that it being such an emotional decision with just so much a concern about this underlying feeling of not caring for their family member. I think that is a really great way to look at it  and to kind of start off that conversation. Now, I'd love to hear more about what drew you to this field when you first got into your career as a neurologist. Dr Weisbrod: I had an interesting journey to doing neuropalliative care. Definitely didn't know that's what I was going to do when I started neurology residency. At University of Rochester, we had amazing palliative care physicians that were involved in medical school, and so I got a little bit of exposure to it early on. Then when I was in neurology residency, I first of all realized that I really enjoyed making sure that what we were doing respected a patient's wishes. And so, as other people seemed to run away from those conversations, I was really drawn to them. And so that definitely made me realize that that might be more of the right field for me. But also, as I went through neurology residency, I really discovered that I love so many different things in neurology, and that made me not want to subspecialize and focus on a narrower set of conditions in neurology. So, doing palliative care fellowship was a really good way of getting a specialist tool set and expanding my knowledge in one area, but staying a neurologist, generalist. And I think it also really enhances a lot of the other things I do in neurology. It gives me a lot of additional skills on how to counsel patients and how to prepare for the future in general. I think there's a lot about just good bedside manner in palliative care education. I feel like it helped me become a better neurologist, and I decided that I really loved the palliative care piece as well.  Dr Grouse: Well, we're certainly all grateful that you found this aspect of your career and have been able to share the skills you've honed with us as well. And we really appreciate you taking the time to talk with us about your excellent article today, which I encourage everybody to read.  Dr Weisbrod: Yeah, thank you. It's been wonderful to be on, and I hope that people can take away a few small points from the article. Dr Grouse: Again, today I've been interviewing Dr Neal Weisbrod about his article on neuropalliative care in dementia, which appears in the December 2025 Continuum issue on neuropalliative care. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Former New York Times reporter and now independent journalist Alex Berenson is the author of “Tell Your Children: The Truth About Marijuana, Mental Illness, and Violence.”In this episode, we dive into the debate around cannabis and THC and President Donald Trump's recent executive order directing the Drug Enforcement Administration (DEA) to reclassify marijuana from a Schedule I to a Schedule III drug.Berenson argues that it's a bad move. Schedule I substances are defined as having high potential for abuse and no accepted medical use. Schedule III substances, in contrast, have medical uses and are regarded as having only moderate to low potential for abuse.Rescheduling marijuana sends the wrong signal, Berenson says: “Do we want to be a society that, in general, encourages drug use?”He believes the use of drugs should be stigmatized, including the use of marijuana: “In the U.S. we can't stigmatize. And not to stigmatize in this case, as in so many cases, means we can't be honest.”In my interview with Berenson, he provides an overview of the dangers of marijuana use and why these have increased dramatically over the last half-century.“Fifty years ago, cannabis that was in a joint that you smoked at Woodstock ... that might have been 1 or 2 percent THC, so a few milligrams of cannabis in a joint. ... When I was growing up in the ‘80s or in the '90s, it might have been 5 percent THC. Now, if you go into a dispensary ... the bud tender will sell you a product that is 20 percent to 30 percent THC, if it's flower cannabis,” he said.And if it's not smoked but vaped, then “that might be 95 percent THC. This is not a plant at all. It's just a chemical to get you high,” Berenson said. “Now you can walk around with this little device and inhale massive amounts of THC, and that really is a change that has made the product a lot more dangerous.”There is also a well-established link, Berenson says, between high-potency, frequent marijuana use, and severe mental health impacts such as psychosis and schizophrenia.There's even research suggesting THC causes heart damage. “There is a link to myocardial infarction, heart attacks, and that link is pretty strong. You can find papers that show a 3x increase over a multi-year period,” he said.But what about its benefits as a pain reliever? Berenson said that he was surprised to discover that placebo-controlled studies showed only small and short-term pain relief effects.“What cannabis and THC are really good at is enhancing sensation ... but if you're in pain, in the long run, enhancing sensation actually is not a good thing for you. ... And so the idea that cannabis is a substitute or a way out of our opioid problem is just not true,” Berenson said.“We as a society have to ... be honest with ourselves about what we are doing and what we are encouraging kids to do,” he said.In our wide-ranging interview, we also discuss the overprescription crisis in America, the dangers of SSRIs, psychedelics, and stimulants such as Adderall that around 10 percent of teenage boys are taking in the United States, and his thoughts on vaccine policy in America.Views expressed in this video are opinions of the host and the guest, and do not necessarily reflect the views of The Epoch Times.

What happens when your family stages an intervention because they've been avoiding you 10 days every month?I'm sharing the story of a patient who had a complete breakdown at Christmas dinner. She snapped at her husband, her kids, her mom, her in-laws—everyone. A few hours later, her family told her: "We love you, but for 10 days every month, we actively avoid you."She came to me asking: Am I bipolar? Am I manic? What's happening to me?This is PMDD premenstrual dysphoric disorder. And when it collides with perimenopause, it becomes a perfect storm. This is not just PMS. This isn't you being dramatic. It's a real biochemical thing happening in your brain an abnormal response to normal hormonal changes.I discuss the science of PMDD: how GABA receptors respond to progesterone metabolites, why some brains are change sensitive, and why the hormonal volatility of perimenopause (erratic estrogen, declining progesterone, unpredictable timing) makes everything exponentially worse. I explain treatment options from luteal-phase SSRIs to Yaz to Duavee for refractory cases, and why tracking your symptoms for at least two cycles is critical for diagnosis.Highlights:Why "I feel like I'm watching myself burn down my life and can't stop it" is the hallmark of PMDD.The DRSP tracking tool: why you need 2 cycles to diagnose PMDD properly.Why Vitex (chasteberry) might help mood swings and breast pain.What Duavee is and why it works for women who can't tolerate progestins.Why Dr. Tammy Rowan calls PMDD a progesterone sensitivity issue.Ulipristal: the emergency contraception drug being studied for PMDD.If you've ever felt like your brain gets hijacked on a schedule, if you've felt completely out of control, this episode is for you. Track your symptoms. Find a clinician who takes cyclic mood symptoms seriously. You don't have to live like this. Please share this episode with someone you know might be experiencing this or a clinician you think would benefit from it.Resource:DRSPDr. Tami RowenGet in Touch with Me:WebsiteInstagramYoutubeSubstackMentioned in this episode:GSM CollectiveThe GSM Collective - Chicago Boutique concierge gynecology practice Led by Dr. Sameena Rahman, specialist in sexual medicine & menopause Unrushed appointments in a beautiful, private setting Personalized care for women's health, hormones, and pelvic floor issues Multiple membership options available Ready for personalized women's healthcare? Visit our Chicago office today. GSM Collective

In this episode of The Truth with Lisa Boothe, Lisa digs into America’s mental health crisis in light of the tragic deaths of Hollywood icon Rob Reiner and his wife Michele — allegedly involving psychiatric medication struggles. Board-certified psychiatrist and former FDA medical officer, Dr. Josef Witt-Doerring joins Lisa to discuss the risks of psychiatric drug over-prescription, hidden side effects of SSRIs and antipsychotics, the impact on youth and developing brains, withdrawal challenges, and how Big Pharma influences the mental health narrative. If you’re curious about the long-term effects of antidepressants, the limits of current research, and how to approach mental health treatment more safely and effectively — this episode is a must-listen. Learn more about Dr. Josef HERESee omnystudio.com/listener for privacy information.

(0:00) Intro(3:36) “Today is your day with the Qur'an” — why he came to medical students(4:28) Who came by choice, who was dragged? An honest audience check(6:23) “Don't listen to what Pakistanis say” — social psychology 101(8:02) Warning: a high-potency “chemistry session” with side effects(9:18) Serotonin 101 — mother's tears and childhood emotional locking(13:01) Money, parents' reactions, and how success gets hard-wired(19:16) When you jump into the Qur'an, it lights up the whole country(20:42) Parliament, VIP protocols, and the side effects of leaving the Qur'an(24:30) Serotonin, titles, and why “Doctor” feels so powerful(32:02) Pharma, protocols, and SSRIs — who really controls thresholds?(40:00) Makeup, niqab, and female serotonin — confidence vs costume(48:05) Endowment effect — flags, clubs, and being “extra Pakistani”(53:05) Bharat Mata, Greater Israel, and why Islam isn't geographically locked(54:05) “You are more Pakistani and less Muslim” — identity breakdown(1:03:20) Pakistan, Pakistan, Pakistan — stuck in the national loop(1:10:04) Mission mode — Sahil as a “missionary” and why he looks for performers(1:18:21) Qur'an, stars, and science — why Muslims should lead global research(1:26:16) Doctors, research, and turning papers into real-world impact(1:32:20) IMS (Islamic Messaging System) platform and next steps for doctors Hosted on Acast. See acast.com/privacy for more information.

In today's episode, your host, Jon LaClare, leads an important conversation that healthcare marketing rarely explains: the placebo effect and why it deserves far more attention. This discussion is inspired by the launch of Pluseebo, a transparent, intentionally humorous product designed to spark awareness around belief, expectation, and honesty in healthcare.While Pluseebo is lighthearted on the surface, its launch highlights a much deeper reality supported by published scientific research. Placebo responses can produce real, measurable biological effects in the body, including changes in brain chemistry, pain perception, and overall wellbeing. These effects are not imagined, and in many clinical trials they closely mirror the average performance of widely prescribed medications.Tune in as Jon breaks down what healthcare advertising often leaves out, including how modest the average benefit of some antidepressants, pain medications, sleep aids, and other common prescriptions can be when compared to placebo, and why side effects and transparency must be part of the conversation. Grounded in respected medical journals and FDA-reviewed data, this episode offers a research-driven perspective designed to inform, challenge assumptions, and elevate the discussion around modern healthcare. Don't miss this timely conversation on belief, biology, and why understanding the placebo effect changes how health products, treatments, and claims should be evaluated.In today's episode of the Harvest Growth Podcast, we'll cover:What the placebo effect actually is, and why it's not “fake.”What large studies reveal about SSRIs, opioids, sleep medications, anxiety medications, ADHD drugs, and statins.Why prescription drug commercials rarely tell the full storyHow transparency in healthcare affects trust and decision-makingHow Pluseebo is designed to spark honest conversations.To learn more about Pluseebo, visit Pluseebo.com.To be a guest on our next episode of the podcast, contact us today!Do you have a brand that you'd like to launch or grow? Do you want help from a partner that has successfully launched hundreds of brands totaling over $2 billion in revenues? Visit HarvestGrowth.com and set up a free consultation with us today!

Send us a textNeurobiology of maternal care in mammals: hormonal influences, stress effects & a study on psilocybin's unexpected effects during the postpartum period.Topics Discussed:Maternal care behavior in rodents: Nursing, pup retrieval, grooming, and nest-building, essential for altricial pups' survival; conserved across mammals but varies by species.Hormonal changes in pregnancy: Estradiol and progesterone surge then drop at birth, crossing the blood-brain barrier to enable infant attraction and care via gene expression and neuroplasticity.Brain circuitry for parenting: Medial preoptic area acts as a central hub, coordinating motivation and sensory inputs; present in both sexes but activated differently by hormones and experience.Stress impacts on mothers: Social stressors like male intruders dysregulate care, leading to frantic behaviors and avoidance; models human psychosocial stress linked to postpartum mood disorders.Sex differences in pup care: Mothers groom male pups more, influencing sexual behaviors, which effects future behavior.Psilocybin in postpartum mice: Single dose increased anxiety in mothers, showed no antidepressant effects, and transferred via milk, causing long-term anhedonia and impairments in offspring as adults.Serotonin system development: Early exposure to serotonergic drugs like psilocybin or SSRIs alters lifelong behavior, highlighting sensitive periods in brain reorganization.Practical Takeaways:Reduce postpartum stress through social support to enhance maternal bonding and minimize mood disorder risks.Approach psychedelics cautiously during postpartum due to potential anxiety increases and offspring effects via milk.Recognize hormonal shifts heighten sensitivity to infant cues, aiding natural caregiving instincts.Monitor environmental factors like food availability or threats that could disrupt parental behaviors in high-stress scenarios.About the guest: Danielle Stolzenberg, PhD is an associate professor of psychology at the University of California, Davis, where her lab studies the neurobiology of maternal care.Reference Paper:Study: Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspringRelated Episode:Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Judson and his husband host an engagement/tree-trimming/Shabbat celebration with a Halloween theme. Brian and Judson's husband have a clandestine meeting without them. Brian thinks he may have come out to his mother about his open marriage. A listener provides some important context around the use of SSRIs. The Hookup of the Week comes from a listener sharing a favorite memory of some public group sex that took him by surprise. They are then joined by actor, comedian and writer Aaron Jackson. Aaron talks about his role as “social justice warrior, but for Instagram” Caden Smucker in Drew Droege's Messy White Gays currently running off-Broadway, how the role is a departure of sorts for him and his journey from theatre school to improv comedy back to acting. He also shares the origin and process of writing his spectacular novel, The Astonishing Life of August March, discusses his longstanding working relationship with prior Dads and Daddies guest, Josh Sharp and their experience as some of the few gay members of Upright Citizens Brigade when they joined.  Other topics covered include whether or not Aaron and his college sweetheart husband could be part of a throuple, his skills in the kitchen, why he christened himself as a “Garbage Troll” on Instagram, and his hatred of completing forms. To close, Aaron helps Brian and Judson respond to a listener's two-part question asking whether or not he is watching too much porn, and for advice on what to do when one looks like a daddy but wants to be a son. Find Aaron Jackson on Instagram https://www.instagram.com/garbagetroll Email your Hookup of the Week, Go Ask Your Dad and Dr. Daddy submissions to dadsanddaddies@gmail.com Dads and Daddies on the Web: https://www.dadsanddaddies.com/ Dads and Daddies on Instagram: https://www.instagram.com/dadsanddaddiespod Dads and Daddies on TikTok: https://www.tiktok.com/@dadsanddaddiespod Dads and Daddies on Bluesky: https://bsky.app/profile/dadsanddaddiespod.bsky.social Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Do SSRIs help your brain?SSRI medications are among the most widely prescribed antidepressants, but what if we've misunderstood how they work? In this interview, Dr. Bret Scher sits down with biochemist and nutrition scientist Dr. Chris Masterjohn to explore a deeper, more systemic view of mental health and how we treat it.Dr. Masterjohn reveals why serotonin isn't just a “mood booster,” how SSRIs may be disrupting mitochondrial function, and why focusing on lifestyle strategies that support brain energy metabolism could unlock new paths for treating depression.

This week on Health Matters, we're sharing an episode of NewYork-Presbyterian's Advances in Care, a show for listeners who want to stay at the forefront of the latest medical innovations and research. On this episode of Advances in Care, host Erin Welsh first hears from Dr. Richard Friedman, a clinical psychiatrist at NewYork-Presbyterian and Director of the Psychopharmacology Clinic at Weill Cornell Medicine. Using his background in psychopharmacology, Dr. Friedman distinguishes between psychedelics and standard antidepressants like SSRIs and SNRIs, explaining the various mechanisms in the brain that respond uniquely to psychedelic compounds. Dr. Friedman also identifies that the challenge of proving efficacy of psychedelic therapy lies in the question of how to design a clinical trial that gives patients a convincing placebo. To learn more about the challenges of trial design, Erin also speaks to Dr. David Hellerstein, a research psychiatrist at NewYork-Presbyterian and Columbia. Dr. Hellerstein contributed to a 2022 trial of synthetic psilocybin in patients with treatment resistant depression. He and his colleagues took a unique approach to dosing patients so that they could better understand the response rates of patients who use psychedelic therapy. The results of that trial underscore an emerging pattern in the field of psychiatry – that while psychedelic therapy has its risks, it's also a promising alternative treatment for countless psychiatric disorders. Dr. Hellerstein also shares more about the future of clinical research on psychedelic therapies to potentially treat a range of mental health disorders.***Dr. Richard Friedman is a professor of clinical psychiatry and is actively involved in clinical research of mood disorders. In particular, he is involved in several ongoing randomized clinical trials of both approved and investigational drugs for the treatment of major depression, chronic depression, and dysthymia.Dr. David J. Hellerstein directs the Depression Evaluation Service at Columbia University Department of Psychiatry, which conducts studies on the medication and psychotherapy treatment of conditions including major depression, chronic depression, and bipolar disorder.___Health Matters is your weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine.To learn more visit: https://healthmatters.nyp.org

In this episode of SHE MD Podcast, Dr. Thaïs Aliabadi and Mary Alice Haney are joined by psychiatrist Dr. Stacy Cohen to explore how hormones shape women's emotional health across life stages. They dive into PMDD, postpartum mental health, perimenopause, and menopause, explaining these transitions as neurological and hormonal events rather than simple mood disorders.Dr. Cohen discusses how progesterone, estrogen, and testosterone affect mood, sleep, libido, and cognition, and why low-dose supplementation can be life-changing. The conversation also clarifies when medications like SSRIs are necessary, the risks of overprescribing without psychiatric follow-up, and how to safely taper or adjust treatments. Listeners learn practical strategies to optimize mental health through hormone therapy, supplements, lifestyle changes, and nervous system regulation.The episode also covers early recognition of perimenopausal changes, postpartum support, and how to advocate for individualized care. Listeners will walk away empowered to understand the role of hormones in emotional regulation, sleep, and relationships, and to seek the care that aligns with their unique needs.Subscribe to SHE MD Podcast for expert tips on PCOS, Endometriosis, fertility, and hormonal balance. Share with friends and visit SHE MD website and Ovii for research-backed resources, holistic health strategies, and expert guidance on women's health and well-being.What You'll Learn How progesterone, estrogen, and testosterone impact mood, sleep, and libido Strategies for using hormone therapy safely during perimenopause and menopause When SSRIs or other medications may be necessary and how to use them responsibly Lifestyle and supplement strategies to support mental health naturallyKey Timestamps00:00 Introduction and episode overview03:40 Explaining what PMDD is05:50 Signs to look out for to identify if you're struggling with PMDD12:50 What the luteal phase us and why patients should be treated during that time24:20 The connection between the nervous system and hormones26:10 Postpartum depression and anxiety34:20 Appropriate use and follow-up of antidepressants41:00 Accessing therapy and psychiatric support for mental health47:40 How complicated perimenopause is57:00 Hormone therapy strategies for mood, sleep, and libido1:00:00 Lifestyle supports: supplements, exercise, and reducing caffeineKey Takeaways Hormones play a central role in women's mental health across life stages Progesterone, estrogen, and testosterone support mood, sleep, libido, and cognition SSRIs and antidepressants should be carefully monitored and not automatically lifelong Supplements, exercise, and lifestyle adjustments complement medical treatment Advocating for individualized care improves long-term emotional and physical well-beingGuest BioStacy Cohen, MD is a double board-certified psychiatrist in General Psychiatry and Addiction Psychiatry. She completed her residency at the University of Chicago and Rush University where she served as Chief of Women's Health and her fellowship at UCLA Medical Center.Drawing on her background as a surgeon, artist, and healer, Dr. Cohen integrates rigorous Western medical training with a whole-person approach. Her work focuses on “rewiring” the nervous system to align the physical, intellectual, emotional, and spiritual self. By targeting the subconscious and addressing mental health from biological, psychological, social, and spiritual perspectives, she helps patients build resilience, strength, and lasting recovery.Frustrated by the fragmentation of outpatient mental health care, Dr. Cohen founded The Moment, a collaborative community of leading professionals dedicated to truly integrative treatment.Links: Instagram: @themomenthealth Instagram: @drstacycohen Website: The Moment Health Certified menopause providers: https://www.menopause.org/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On today's episode, Dr. Mark Costes is joined by his good friend and fellow Black Belt Coach, Dr. Taher Dhoon—co-founder of the Colorado Surgical Institute and owner of an 18-operatory dental practice—for a deep dive into implant complications. They kick things off with a candid conversation on time management, shiny object syndrome, and how to balance business success with family life and fulfillment. Dr. Dhoon shares the systems he uses to juggle clinical days, content creation, and high-level strategy, including his cleverly titled "Get Your Sh*t Done" days.   From there, they dive into the nitty-gritty of implant surgery complications—from the importance of case selection and managing patient expectations, to specific pre-op protocols like vitamin D, antibiotic regimens, and why SSRIs and bisphosphonates need extra attention. Dr. Dhoon also outlines his intraoperative strategies for preventing failures, such as the 50/50 drilling technique and why 45 Ncm of torque should be your new standard. The episode wraps with a practical post-op game plan for soft tissue management, follow-up protocols, and how to handle setbacks with confidence and composure. This conversation is a masterclass in surgical systems thinking, built from years of real-world experience. Be sure to check out the full episode from the Dentalpreneur Podcast! EPISODE RESOURCES Dr. Taher Dhoon – (858) 692-3533‬ Chris Richards – (970) 420-6148‬ https://www.truedentalsuccess.com Dental Success Network Subscribe to The Dentalpreneur Podcast

Depression tanks your libido. Then you finally get help with antidepressants—and your sex drive tanks even more. If this is you, you're not broken. You're dealing with a real, common side effect that nobody wants to talk about.In this episode, I break down the double whammy of depression and SSRIs on your sex life: how depression shuts down motivation (including for sex), why antidepressants compound the problem by affecting serotonin and dopamine, and how orgasm difficulties create a feedback loop that kills desire even further.I also share my personal story—how I dealt with depression, the mental scripts generating self-hatred that my brain was trying to protect me from, and how I got off meds through coaching and massive self-compassion work. Literally re-writing the thoughts in my head changed everything.We cover: what you can actually do about it (medication options, body-based approaches, relationship support), why this isn't your fault, and how to stop choosing between mental health and a satisfying sex life.Quick note: I'm not a medical doctor—this is educational, not medical advice. Always talk to your doctor about medication decisions.Get my free guide: 5 Steps to Start Solving Desire Differences (Without Blame or Shame), A Practical Starting Point for Individuals and Couples, at https://laurajurgens.com/libido Find out more about me at https://laurajurgens.com/

Allie interviews Dr. Josef Witt-Doerring, a psychiatrist and former FDA drug safety officer. He unveils the truth about Big Pharma and the detrimental side effects of medications for mental illnesses. SSRIs cause more harm than good; they blunt emotions, breed dependency, and often backfire long-term. Dr. Witt-Doerring advises patients to pursue holistic health that includes a balanced diet, sleep, exercise, and therapy. He and his wife have started TaperClinic, where they help people come off medications and find real solutions to their problems. Join us for an eye-opening discussion about the dark side of the pharmaceutical industry. Check out more about Dr. Witt-Doerring's TaperClinic here: ⁠taperclinic.com⁠ Buy Allie's book "Toxic Empathy: How Progressives Exploit Christian Compassion": ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.toxicempathy.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Timecodes: (00:00) Intro (09:45) Misdiagnosing Mental Illness (19:20) Drug Safety Officer (25:05) Corruption in Medical Academia (27:50) Wake-Up Call (34:35) Problems with SSRIs (46:00) Short-Term vs. Long-Term Medication (53:50) TaperClinic --- Today's Sponsors: PreBorn — Would you consider a gift to save babies in a big way? Your gift will be used to save countless babies for years to come. To donate, dial #250 and say the keyword BABY or donate securely at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠preborn.com/allie⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Good Ranchers — Give a reason to gather. Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠goodranchers.com⁠⁠⁠⁠⁠⁠⁠⁠⁠ to start gifting, and while you're there, treat yourself with your own subscription to America's best meat. And when you use the code ALLIE, you'll get $40 off your first order. EveryLife — Visit ⁠⁠⁠⁠⁠everylife.com⁠⁠⁠⁠⁠ and use promo code ALLIE10 to get 10% off your first order today!  Patriot Mobile — Switching to Patriot Mobile is easier than ever. Activate in minutes from your home or office. Keep your number, keep your phone, or upgrade. Go to ⁠⁠⁠patriotmobile.com/allie⁠⁠⁠ or call 972-PATRIOT, and use promo code ALLIE for a free month of service! Cozy Earth — Give the gift of everyday luxury this holiday season. Head to ⁠cozyearth.com⁠ and use the code RELATABLE for up to 40% off — just be sure to place your order by December 12 for guaranteed Christmas delivery. --- Episodes you might like:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Ep 1189 | SSRIs Are Rewiring Babies' Brains — and Killing Their Moms | Guest: Dr. Adam Urato ⁠https://podcasts.apple.com/us/podcast/ep-1189-ssris-are-rewiring-babies-brains-and-killing/id1359249098?i=1000708507649⁠ Ep 821 | Why Antidepressants Don't Fix Depression | Guest: Dr. Roger McFillin ⁠⁠https://podcasts.apple.com/us/podcast/ep-821-why-antidepressants-dont-fix-depression-guest/id1359249098?i=1000616890403⁠⁠ Ep 822 | The Big Money Behind Big Medicine | Guest: Dr. Roger McFillin ⁠⁠https://podcasts.apple.com/us/podcast/ep-822-the-big-money-behind-big-medicine-guest-dr/id1359249098?i=1000617050991⁠⁠ Ep 1031 | Psychiatry Is Killing People | Guest: Dr. Roger McFillin ⁠⁠https://podcasts.apple.com/us/podcast/ep-1031-psychiatry-is-killing-people-guest-dr-roger/id1359249098?i=1000661830317⁠⁠ --- Buy Allie's book "You're Not Enough (and That's Okay): Escaping the Toxic Culture of Self-Love": ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.alliebethstuckey.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Relatable merchandise: Use promo code ALLIE10 for a discount: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://shop.blazemedia.com/collections/allie-stuckey⁠⁠⁠⁠⁠⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

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Read the full transcript here. Where is the line between ordinary intrusive thoughts and an OCD pattern that hijacks the day? How do obsessions and compulsions condition each other so that brief relief entrenches the loop? What clinical markers - ego-dystonic content and intact reality testing - separate OCD from psychosis? How do thought–action fusion, inflated responsibility and “zero-risk” striving amplify checking and covert mental rituals? Why does repeated checking degrade memory confidence and widen doubt? How should ERP be structured to target hidden mental rituals as well as visible behaviors, and what metrics best define success? When are SSRIs a helpful platform for ERP, and why are effective doses often higher than for depression? What boundaries and scripts help families avoid reassurance and accommodation while staying empathic? How do culture and news cycles shape obsession themes without changing the underlying mechanism? What relapse-prevention practices keep gains durable - normalizing setbacks, tracking triggers, and refocusing on work, love, and presence? David Adam is an author and journalist, who covers science, environment, technology, medicine and the impact they have on people, culture and society. After nearly two decades as a staff writer and editor at Nature and the Guardian, David set up as a freelancer in 2019. David's book - The Man Who Couldn't Stop - is his attempt to understand the condition and his experiences with OCD, where he explores the weird thoughts that exist within every mind and explains how they drive millions of us toward obsession and compulsion. Links: The Man Who Couldn't Stop: OCD and the True Story of a Life Lost in Thought Staff Spencer Greenberg — Host + Director Ryan Kessler — Producer + Technical Lead WeAmplify — Transcriptionists Igor Scaldini — Marketing Consultant Music Broke for Free Josh Woodward Lee Rosevere Quiet Music for Tiny Robots wowamusic zapsplat.com Affiliates Clearer Thinking GuidedTrack Mind Ease Positly UpLift [Read more]

I had goosebumps during this conversation with Johanna Dahlman, the Alopecia Angel. Her story from devastating hair loss diagnosis to growing thick hair an inch per month shows what's possible when you stop treating symptoms and start healing root causes. What really amazed me is that 90% of her clients see hair growth in under 8 weeks. Not through quick fixes, but by identifying blind spots like medications (birth control, SSRIs), hair products in active lawsuits, breast implants triggering autoimmune responses, and environmental toxins we never consider. This isn't just about hair though; it's about whole health. Her clients don't just regrow hair, they get their energy back, joint pain disappears, and they show up differently in relationships and careers. If you're dealing with any type of hair loss or autoimmunity, this conversation will shift how you think about healing. For the complete show notes, links and transcripts, visit inspiredliving.show/221

In this special AMA episode, Paul F. Austin answers the most common, and most nuanced questions emerging from recent trainings, webinars, and community sessions. Drawing from a decade of experience in microdosing, facilitation, and practitioner training, Paul explores how to choose the right microdosing protocol, the relationship between nervous system health and performance, the role of psychedelics in coaching, and the ethical boundaries practitioners must uphold. He also discusses SSRI tapering, creativity, leadership, and how to guide clients through integration with clarity and skill. Highlights How to choose a microdosing protocol Why nervous system health comes first Microdosing vs. macrodosing for integration SSRIs, tapering, and safe sequencing Creativity and leadership with microdosing Embodiment as the key to integration Coaching vs. therapy in psychedelic work Ethical boundaries for practitioners Episode Links Free Webinar on Dec 11, 2025: Social Media, Psychedelics, and the Law: What Practitioners Need to Know Practitioner Certification Program Microdosing Practitioner Certification

In this Write Big session of the #amwriting podcast, host Jennie Nash welcomes Pulitzer Prize–winning journalist Jennifer Senior for a powerful conversation about finding, knowing, and claiming your voice.Jennifer shares how a medication once stripped away her ability to think in metaphor—the very heart of her writing—and what it was like to get that voice back. She and Jennie talk about how voice strengthens over time, why confidence and ruthless editing matter, and what it feels like when you're truly writing in flow.It's an inspiring reminder that your voice is your greatest strength—and worth honoring every time you sit down to write.TRANSCRIPT BELOW!THINGS MENTIONED IN THIS PODCAST:* Jennifer's Fresh Air interview with Terry Gross: Can't Sleep? You're Not Alone* Atlantic feature story: What Bobby McIlvaine Left Behind* Atlantic feature story: The Ones We Sent Away* Atlantic feature story: It's Your Friends Who Break Your Heart* The New York Times article: Happiness Won't Save You* Heavyweight the podcastSPONSORSHIP MESSAGEHey, it's Jennie Nash. And at Author Accelerator, we believe that the skills required to become a great book coach and build a successful book coaching business can be taught to people who come from all kinds of backgrounds and who bring all kinds of experiences to the work. But we also know that there are certain core characteristics that our most successful book coaches share. If you've been curious about becoming a book coach, and 2026 might be the year for you, come take our quiz to see how many of those core characteristics you have. You can find it at bookcoaches.com/characteristics-quiz.EPISODE TRANSCRIPTJennie NashHi, I'm Jennie Nash, and you're listening to the Hashtag AmWriting Podcast. This is a Write Big Session, where I'm bringing you short episodes about the mindset shifts that help you stop playing small and write like it matters. This one might not actually be that short, because today I'm talking to journalist Jennifer Senior about the idea of finding and knowing and claiming your voice—a rather big part of writing big. Jennifer Senior is a staff writer at The Atlantic. She won the Pulitzer Prize for feature writing in 2022 and was a finalist again in 2024. Before that, she spent five years at The New York Times as both a daily book critic and a columnist for the opinion page, and nearly two decades at New York Magazine. She's also the author of a bestselling parenting book, and frequently appears on NPR and other news shows. Welcome, Jennifer. Thanks for joining us.Jennifer SeniorThank you for having me. Hey, I got to clarify just one thing.Jennie NashOh, no.Jennifer SeniorAll Joy and No Fun is by no means a parenting book. I can't tell you the first thing about how to raise your kids. It is all about how kids change their parents. It's all like a sociological look at who we become and why we are—so our lives become so vexed. I like, I would do these book talks, and at the end, everybody would raise their hand and be like, “How do I get my kid into Harvard?” You know, like, the equivalent obviously—they wouldn't say it that way. I'd be like; I don't really have any idea, or how to get your kid to eat vegetables, or how to get your kid to, like, stop talking back. But anyway, I just have to clarify that, because every time...Jennie NashPlease, please—Jennifer SeniorSomeone says that, I'm like, “Noooo.” Anyway, it's a sociology book. Ah, it's an ethnography, you know. But anyway, it doesn't matter.Jennie NashAll right, like she said, you guys—not what I said.Jennifer SeniorI'm not correcting you. It came out 11 years ago. There were no iPads then, or social media. I mean, forget it. It's so dated anyway. But like, I just...Jennie NashThat's so funny. So the reason that we're speaking is that I heard you recently on Fresh Air with Terry Gross, where you were talking about an Atlantic feature story that you wrote called “Why Can't Americans Sleep?” And this was obviously a reported piece, but also a really personal piece and you're talking about your futile attempts to fall asleep and the latest research into insomnia and medication and therapy that you used to treat it, and we'll link to that article and interview in the show notes. But the reason that we're talking, and that in the middle of this conversation, which—which I'm listening to and I'm riveted by—you made this comment, and it was a little bit of a throwaway comment in the conversation, and, you know, then the conversation moved on. But you talked about how you were taking a particular antidepressant you'd been prescribed, and this was the quote you said: “It blew out all the circuitry that was responsible for generating metaphors, which is what I do as a writer. So it made my writing really flat.” And I was just like, hold up. What was that like? What happened? What—everything? So that's why we're talking. So… can we go back to the very beginning? If you can remember—Jess Lahey actually told me that when she was teaching fifth and sixth grade, that's around the time that kids begin to grasp this idea of figurative language and metaphor and such. Do you remember learning how to write like that, like write in metaphor and simile and all such things?Jennifer SeniorOh, that's funny. Do I remember it? I remember them starting to sort of come unbidden in my—like they would come unbidden in my head starting maybe in my—the minute I entered college, or maybe in my teens. Actually, I had that thing where some people have this—people who become writers have, like, a narrator's voice in their head where they're actually looking at things and describing them in the third person. They're writing them as they witness the world. That went away, that narrator's voice, which I also find sort of fascinating. But, like, I would say that it sort of emerged concurrently. I guess I was scribbling a little bit of, like, short story stuff, or I tried at least one when I was a senior in high school. So that was the first time maybe that, like, I started realizing that I had a flair for it. I also—once I noticed that, I know in college I would make, you know, when I started writing for the alternative weekly and I was reviewing things, particularly theater, I would make a conscientious effort to come up with good metaphors, and, like, 50% of them worked and 50% of them didn't, because if you ever labor over a metaphor, there's a much lower chance of it working. I mean, if you come—if you revisit it and go, oh, that's not—you know, that you can tell if it's too precious. But now if I labor over a metaphor, I don't bother. I stop. You know, it has to come instantaneously or...Jennie NashOr that reminds me of people who write with the thesaurus open, like that's going to be good, right? That's not going to work. So I want to stick with this, you know, so that they come into your head, you recognize that, and just this idea of knowing, back in the day, that you could write like that—you… this was a thing you had, like you used the word “flair,” like had a flair for this. Were there other signs or things that led you to the work, like knowing you were good, or knowing when something was on the page that it was right, like, what—what is that?Jennifer SeniorIt's that feeling of exhilaration, but it's also that feeling of total bewilderment, like you've been struck by something—something just blew through you and you had nothing to do with it. I mean, it's the cliché: here I am saying the metaphors are my superpower, which my editors were telling me, and I'm about to use a cliché, which is that you feel like you're a conduit for something and you have absolutely nothing to do with it. So I would have that sense that it had almost come without conscious thought. That was sort of when I knew it was working. It's also part of being in a flow state. It's when you're losing track of time and you're just in it. And the metaphors are—yeah, they're effortless. By the way, my brain is not entirely fogged in from long COVID, but I have noticed—and at first I didn't really notice any decrements in cognition—but recently, I have. So I'm wondering now if I'm having problems with spontaneous metaphor generation. It's a little bit disconcerting. And I do feel like all SSRIs—and I'm taking one now, just because, not just because long COVID is depressing, but because I have POTS, which is like a—it's Postural Orthostatic Tachycardia Syndrome, and that's a very common sequela from long COVID, and it wipes out your plasma serotonin. So we have to take one anyway, we POTS patients. So I found that nicotine often helped with my long COVID, which is a thing—like a nicotine patch—and that made up for it. It almost felt like I was doping [laughing]. It made my writing so much better. But it's been...Jennie NashWait, wait, wait, this is so interesting.Jennifer SeniorI know…it's really weird. I would never have guessed that so much of my writing would be dampened by Big Pharma. I mean—but now with the nicotine patches, I was like, oh, now I get why writers are smoking until into the night, writing. Like, I mean, and I always wished that I did, just because it looked cool, you know? I could have just been one of those people with their Gitanes, or however you pronounce it, but, yeah.Jennie NashWow. So I want to come—I want to circle back to this in a minute, but let's get to the first time—well, it sounds like the first time that happened where you were prescribed an antidepressant and—and you recognized that you lost the ability to write in metaphor. Can you talk about—well, first of all, can you tell us what the medication was?Jennifer SeniorYeah, it was Paxil, which is actually notorious for that. And at the top—which I only subsequently discovered—those were in the days where there were no such things as Reddit threads or anything like that. It was 1999… I guess, no, eight, but so really early. That was the bespoke antidepressant at the time, thought to be more nuanced. I think it's now fallen out of favor, because it's also a b***h to wean off of. But it was kind of awful, just—I would think, and nothing would come. It was the strangest thing. For—there's all this static electricity usually when you write, right? And there's a lot of free associating that goes on that, again, feels a little involuntary. You know, you start thinking—it's like you've pulled back the spring in the pinball machine, and suddenly the thing is just bouncing around everywhere, and the ball wasn't bouncing around. Nothing was lighting up. It was like a dis… it just was strange, to be able to summon nothing.Jennie NashWow. So you—you just used this killer metaphor to describe that.Jennifer SeniorYeah, that was spontaneous.Jennie NashRight? So—so you said first, you said static, static energy, which—which is interesting.Jennifer SeniorYeah, it's... [buzzing sound]Jennie NashYeah. Yeah. Because it's noisy. You're talking about...Jennie SeniorOh, but it's not disruptive noise. Sorry, that might seem like it's like unwanted crackling, like on your television. I didn't really—yeah, maybe that's the wrong metaphor, actually, maybe the pinball is sort of better, that all you need is to, you know, psych yourself up, sit down, have your caffeine, and then bam, you know? But I didn't mean static in that way.Jennie NashI understood what you meant. There's like a buzzy energy.Jennifer SeniorYeah, right. It's fizz.Jennie NashFizz... that's so good. So you—you recognized that this was gone.Jennifer SeniorSo gone! Like the TV was off, you know?Jennie NashAnd did you...?Jennifer SeniorOr the machine, you know, was unplugged? I mean, it's—Jennie NashYeah, and did you? I'm just so curious about the part of your brain that was watching another part of your brain.Jennifer Senior[Laughing] You know what? I think... oh, that's really interesting. But are you watching, or are you just despairing because there's nothing—I mean, I'm trying to think if that's the right...Jennie NashBut there's a part of your brain that's like, this part of my brain isn't working.Jennifer SeniorRight. I'm just thinking how much metacognition is involved in— I mean, if you forget a word, are you really, like, staring at that very hard, or are you just like, s**t, what's the word? If you're staring at Jack Nicholson on TV, and you're like, why can't I remember that dude's name?Multiple speakers[Both laughing]Jennifer SeniorWhich happens to me far more regularly now, [unintelligible]… than it used to, you know? I mean, I don't know. There is a part of you that's completely alarmed, but, like, I guess you're right. There did come a point where I—you're right, where I suddenly realized, oh, there's just been a total breakdown here. It's never happening. Like, what is going on? Also, you know what would happen? Every sentence was a grind, like...Jennie NashOkay, so—okay, so...Jennifer Senior[Unintelligible]... Why is this so effortful? When you can't hold the previous sentence in your head, suddenly there's been this lapse in voice, right? Because, like, if every sentence is an effort and you're starting from nothing again, there's no continuity in how you sound. So, I mean, it was really dreadful. And by the way, if I can just say one thing, sorry now that—Jennie NashNo, I love it!Jennifer SeniorYeah. Sorry. I'm just—now you really got me going. I'm just like, yeah, I know. I'm sort of on a tear and a partial rant, which is Prozac—there came a point where, like, every single SSRI was too activating for me to sleep. But it was, of course, a problem, because being sleepless makes you depressed, so you need something to get at your depression. And SNRIs, like the Effexor's and the Cymbalta's, are out of the question, because those are known to be activating. So I kept vainly searching for SSRIs, and Prozac was the only one that didn't—that wound up not being terribly activating, besides Paxil, but it, too, was somewhat deadening, and I wrote my whole book on it.Jennie NashWow!Jennifer SeniorIt's not all metaphor.Multiple Speakers[both laughing]Jennifer SeniorIt's not all me and no—nothing memorable, you know? I mean, it's—it's kind of a problem. It was—I can't really bear to go back and look at it.Jennie NashWow.Jennie NashSo—so the feeling...Jennifer SeniorI'm really giving my book the hard sell, like it's really a B plus in terms of its pro…—I mean, you know, it wasn't.Jennie NashSo you—you—you recognize its happening, and what you recognize is a lack of fizzy, buzzy energy and a lack of flow. So I just have to ask now, presumably—well, there's long COVID now, but when you don't have—when you're writing in your full powers, do you—is it always in a state of flow? Like, if you're not in a state of flow, do you get up and go do something else? Like, what—how does that function in the life of a writer on a deadline?Jennifer SeniorOK. Well, am I always in a state of flow? No! I mean, flow is not—I don't know anyone who's good at something who just immediately can be in flow every time.Jennie NashYeah.Jennifer SeniorIt's still magic when it happens. You know, when I was in flow almost out of the gate every day—the McIlvaine stories—like, I knew when I hit send, this thing is damn good. I knew when I hit send on a piece that was not as well read, but is like my second or third favorite story. I wrote something for The New York Times called “Happiness Wont Save You,” about a pioneer in—he wrote one of the foundational studies in positive psychology about lottery winners and paraplegics, and how lottery winners are pretty much no happier than random controls found in a phone book, and paraplegics are much less unhappy than you might think, compared to controls. It was really poorly designed. It would never withstand the scrutiny of peer review today. But anyway, this guy was, like, a very innovative thinker. His name was Philip Brickman, and in 1982 at 38 years old, he climbed—he got—went—he found his way to the roof of the tallest building in Ann Arbor and jumped, and took his own life. And I was in flow pretty much throughout writing that one too.Jennie NashWow. So the piece you're referring to, that you referred to previous to that, is What Bobby McIlvaine Left Behind, which was a feature story in The Atlantic. It's the one you won the—Pul…Pulitzer for? It's now made into a book. It has, like...Jennifer SeniorAlthough all it is like, you know, the story between...Jennie NashCovers, right?Jennifer SeniorYeah. Yeah. Because—yeah, yeah.Jennie NashBut—Jennifer SeniorWhich is great, because then people can have it, rather than look at it online, which—and it goes on forever—so yeah.Jennie NashSo this is a piece—the subtitle is Grief, Conspiracy Theories, and One Family's Search for Meaning in the Two Decades Since 9/11—and I actually pulled a couple of metaphors from that piece, because I re-read it knowing I was going to speak to you… and I mean, it was just so beautifully written. It's—it's so beautifully structured, everything, everything. But here's a couple of examples for our listeners. You're describing Bobby, who was a 26-year-old who died in 9/11, who was your brother's college roommate.Jennifer SeniorAnd at that young adult—they—you can't afford New York. They were living together for eight years. It was four in college, and four—Jennie NashWow.Jennifer SeniorIn New York City. They had a two-bedroom... yeah, in a cheaper part... well, to the extent that there are cheaper parts in...Jennie NashYeah.Jennifer SeniorThe way over near York Avenue, east side, yeah.Jennie NashSo you write, “When he smiled, it looked for all the world like he'd swallowed the moon.” And you wrote, “But for all Bobby's hunger and swagger, what he mainly exuded, even during his college years, was warmth, decency, a corkscrew quirkiness.” So just that kind of language—a corkscrew quirkiness, like he'd swallowed the moon—that, it's that the piece is full of that. So that's interesting, that you felt in flow with this other piece you described and this one. So how would you describe—so you describe metaphors as things that just come—it just—it just happens. You're not forcing it—you can't force it. Do you think that's true of whatever this ineffable thing of voice—voices—as well?Jennifer SeniorOh, that's a good question. My voice got more distinct as I got older—it gets better. I think a lot of people's—writers'—powers wax. Philip Roth is a great example of that. Colette? I mean, there are people whose powers really get better and better, and I've gotten better with more experience. But do you start with the voice? I think you do. I don't know if you can teach someone a voice.Jennie NashSo when you say you've gotten better, what does that mean to you?Jennifer SeniorYeah. Um, I'm trying to think, like, do I write with more swing? Do I—just with more confidence because I'm older? Being a columnist…which is the least creative medium…Jennie NashYeah.Jennifer SeniorSeven hundred and fifty words to fit onto—I had a dedicated space in print. When David Leonhardt left, I took over the Monday spot, during COVID. So it's really, really—but what it forces you to do is to be very—your writing becomes lean, and it becomes—and structure is everything. So this does not relate to voice, but my—I was always pretty good at structure anyway. I think if you—I think movies and radio, podcasts, are, like, great for structure. Storytelling podcasts are the best thing to—I think I unconsciously emulate them. The McIlvaine story has a three-act structure. There's also—I think the podcast Heavyweight is sublime in that way.Jennie NashIs that Roxane Gay?Jennifer SeniorNo, no, no, no.Jennie NashOh, it's, um—Jennifer SeniorIt's Jonathan Goldstein.Jennie NashYes, got it. I'm going to write that down and link to that in our show notes.Jennifer SeniorIt's... I'm trying to think of—because, you know, his is, like, narratives, and it's—it's got a very unusual premise. But voice, voice, voice—well, I, you know, I worked on making my metaphors better in the beginning. I worked on noticing things, you know, and I worked on—I have the—I'm the least visual person alive. I mean, this is what's so interesting. Like, I failed to notice once that I had sat for an hour and a half with a woman who was missing an arm. I mean, I came back to the office and was talking—this is Barbara Epstein, who was a storied editor of The New York Review of Books, the story editor, along with Bob Silver. And I was talking to Mike Tomasky, who was our, like, city politic editor at the time. And I said to him, I just had this one—I knew she knew her. And he said, was it awkward? Was—you know, with her having one arm and everything? And I just stared at him and went one arm? I—I am really oblivious to stuff. And yet visual metaphors are no problem with me. Riddle me that, Batman. I don't know why that is. But I can, like, summon them in my head, and so I worked at it for a while, when my editors were responsive to it. Now they come more easily, so that seems to maybe just be a facility. I started noticing them in other people's writing. So Michael Ondaatje —in, I think it was In the Skin of a Lion, but maybe it was The English Patient. I've read, like, every book of his, like I've, you know— Running… was it Running in the Family? Running with the Family? I think it was Running in the—his memoir. And, I mean, doesn't—everything. Anil's Ghost—he— you know, that was it The Ballad of Billy the Kid? [The Collected Works of Billy the Kid] Anyway, I can go on and on. He had one metaphor talking about the evening being as serene as ink. And it was then that I realized that metaphors without effort often—and—or is that a simile? That's a simile.Jennie NashLike—or if it's “like” or “as,” it's a simile.Jennifer SeniorYeah. So I'm pretty good with similes, maybe more than metaphors. But... serene as ink. I realized that what made that work is that ink is one syllable. There is something about landing on a word with one syllable that sounds like you did not work particularly hard at it. You just look at it and keep going. And I know that I made a real effort to make my metaphors do that for a while, and I still do sometimes. Anything more than that can seem labored.Jennie NashOh, but that's so interesting. So you—you noticed in other people what worked and what you liked, and then tried to fold that into your own work.Jennifer SeniorYeah.Jennie NashSo does that mean you might noodle on—like, you have the structure of the metaphor or simile, but you might noodle on the word—Jennifer SeniorThe final word?Jennie NashThe final word.Jennifer SeniorYeah. Yeah, the actual simile, or whatever—yeah, I guess it's a simile—yeah, sometimes. Sometimes they—like I said, they come unbidden. I think I have enough experience now—which may make my voice better—to know what's crap. And I also, by the way, I'll tell you what makes your voice better: just being very willing to hit Select Alt, Delete. You know, there's more where that came from. I am a monster of self-editing. I just—I have no problem doing it. I like to do it. I like to be told when things are s**t. I think that improves your voice, because you can see it on the page.Jennie NashYeah.Jennifer SeniorAnd also, I think paying attention to other people's writing, you know, I did more and more of that, you know, reverse engineering stuff, looking at how they did stuff as I got older, so...Jennie NashSo I was going to ask a question, which now maybe you already answered, but the question was going to be… you said that you're—you feel like you're getting better as a writer as you got older. And you—you said that was due to experience. And I was going to ask, is it, or is it due to getting older? You know, is there something about literally living more years that makes you better, or, you know, like, is wisdom something that you just get, or is it something you work for? But I think what I'm hearing is you're saying you have worked to become the kind of writer who knows, you know, what you just said—you delete stuff, it comes again. But tell me if—you know, you welcome the kind of tough feedback, because you know that makes you better. You know, this sort of real effort to become better, it sounds like that's a practice you have. Is that—is that right?Jennifer SeniorOh yeah. I mean, well, let's do two things on that, please. I so easily lose my juju these days that, like, you've got to—if you can put a, you know, oh God, I'm going to use a cliché again—if you can put a pin in or bookmark that, the observation about, you know, harsh feedback. I want to come back to that. But yes, one of the things that I was going to keep—when I said that I have the confidence now, I also was going to say that I have the wisdom, but I had too many kind of competing—Jennie NashYeah. Yeah.Jennifer SeniorYou know, were running at once, and I, you know, many trains on many tracks—Jennie NashYeah, yeah.Jennifer Senior…about to leave, so…, Like, I had to sort of hop on one. But, like, the—the confidence and wisdom, yes, and also, like, I'll tell you something: in the McIlvaine piece, it may have been the first time I did, like, a narrative nonfiction. I told a story. There was a time when I would have hid behind research on that one.Jennie NashOoh, and did you tell a story. It was the—I remember reading that piece when it first came out, and there you're introducing, you know, this—the situation. And then there's a moment, and it comes very quickly at the top of the piece, where you explain your relationship to the protagonist of the story. And there's a—there's just a moment of like, oh, we're—we're really in something different here. There's really—is that feel of, this is not a reported story, this is a lived story, and that there's so many layers of power, I mean, to the story itself, but obviously the way that you—you present it, so I know exactly what you're talking about.Jennifer SeniorYeah, and by the way, I think writing in the first person, which I've been doing a lot of lately, is not something I would have done until now. Probably because I am older and I feel like I've earned it. I have more to say. I've been through more stuff. It's not, like, with the same kind of narcissism or adolescent—like, I want to get this out, you know. It's more searching, I think, and because I've seen more, and also because I've had these pent up stories that I've wanted to tell for a long time. And also I just don't think I would have had the balls, you know.Jennie NashRight.Jennifer SeniorSo some of it is—and I think that that's part of—you can write better in your own voice. If it's you writing about you, you're—there's no better authority, you know? So your voice comes out.Jennie NashRight.Jennifer SeniorBut I'm trying to think of also—I would have hid behind research and talked about theories of grief. And when I wrote, “It's the damnedest thing, the dead abandon you, and then you abandon the dead,” I had blurted that out loud when I was talking to, actually, not Bobby's brother, which is the context in which I wrote it, but to Bobby's—I said that, it's, like, right there on the tape—to his former almost fiancée. And I was thinking about that line, that I let it stand. I didn't actually then rush off and see if there was a body of literature that talked about the guilt that the living feel about letting go of their memories. But I would have done that at one point. I would have turned it into this... because I was too afraid to just let my own observations stand. But you get older and you're like, you know what? I'm smart enough to just let that be mine. Like, assume...Jennie NashRight.Jennifer SeniorIt's got to be right. But can we go back, also, before I forget?Jennie NashYeah, we're going to go back to harsh, but—but I would just want to use your cliché, put a pin in what you said, because you've said so many important things— that there's actual practice of getting better, and then there's also wisdom of—of just owning, growing into, embracing, which are two different things, both so important. So I just wanted to highlight that you've gone through those two things. So yes, let's go back to—I said harsh, and maybe I miss—can...misrepresenting what you meant.Jennifer SeniorYou may not have said that. I don't know what you said.Jennie NashNo, I did, I did.Jennifer SeniorYou did, okay, yeah, because I just know that it was processed as a harsh—oh no, totally. Like, I was going to say to you that—so there was a part of my book, my book, eventually, I just gave one chapter to each person in my life whom I thought could, like, assess it best, and one of them, so this friend—I did it on paper. He circled three paragraphs, and he wrote, and I quote, “Is this just a shitty way of saying...?” And then I was like, thank God someone caught it, if it was shitty. Oh my God. And then—and I was totally old enough to handle it, you know, I was like 44, whatever, 43. And then, who was it? Someone else—oh, I think I gave my husband the intro, and he wrote—he circled a paragraph and just wrote, “Ugh.” Okay, Select Alt, Delete, redo. You know, like, what are you going to do with that? That's so unambiguous. It's like, you know—and also, I mean, when you're younger, you argue. When you're older, you never quarrel with Ugh. Or Is this...Jennie NashRight, you're just like, okay, yep.Jennifer SeniorYeah. And again, you—you've done it enough that, you know, there's so much more where that came from.Jennie NashYeah.Jennifer SeniorWhy cling to anything that someone just, I don't know, had this totally allergic reaction to? Like, you know, if my husband broke out in a hive.Jennie NashYeah. So, circling back to the—the storyline of—you took this medication, you lost your ability to write in this way, you changed medications, presumably, you got it back. What did it feel like to get it back? Did you—do you remember that?Jennifer SeniorOh God, yes, it was glorious.Jennie NashReally?!Jennifer SeniorOh, you don't feel like yourself. I think that—I mean, I think there are many professions that are intertwined with identity. They may be the more professional—I'm sorry, the more creative professions. But not always, you know. And so if your writing voice is gone, and it's—I mean, so much of writing is an expression of your interior, if not life, then, I don't know some kind of thought process and something that you're working out. To have that drained out of you, for someone to just decant all the life out of your—or something to decant all the life out of your writing, it's—it's, I wouldn't say it's traumatic, that's totally overstating it, but it's—it's a huge bummer. It's, you know, it's depressing.Jennie NashWell, the word glorious, that's so cool. So to feel that you got back your—the you-ness of your voice was—was glorious. I mean, that's—that's amazing.Jennifer SeniorWhat—if I can just say, I wrote a feature, right, that then, like, I remember coming off of it, and then I wrote a feature that won the News Women's Club of New York story for best feature that year. Like, I didn't realize that those are kind of hard to win, and not like I won... I think I've won one since. But, like, that was in, like, 99 or something. I mean, like, you know, I don't write a whole lot of things that win stuff, until recently, you know. There was, like, a real kind of blackout period where, you know, I mean, but like—which I think, it probably didn't have to do with the quality of my writing. I mean, there was—but, I mean, you know, I wasn't writing any of the stuff that floated to the tippy top, and, like, I think that there was some kind of explosion thereof, like, all the, again, stuff that was just desperate to come out. I think there was just this volcanic outpouring.Jennie NashSo you're saying now you are winning things, which is indeed true. I mean, Pulitzer Prizes among them. Do you think that that has to do with this getting better? The wisdom, the practice, the glorious having of your abilities? Or, I guess what I'm asking is, like, is luck a part of—a part of all that? Is it just, it just happens? Or do you think there's some reason that it's happening? You feel that your writing is that powerful now?Jennifer SeniorWell, luck is definitely a part of it, because The Atlantic is the greatest place to showcase your feature writing. It gets so much attention, even though I think fewer people probably read that piece about Bobby McIlvaine than would have read any of my columns on any given day. The kind of attention was just so different. And it makes sense in a funny way, because it was 13,600 words or something. I mean, it was so long, and columns are 750 words. But, like, I think that I just lucked out in terms of the showcase. So that's definitely a part of it. And The Atlantic has the machinery to, you know, and all these dedicated, wonderful publicity people who will make it possible for people to read it, blah, blah, blah. So there's that. If you're older, you know everyone in the business, so you have people amplifying your work, they're suddenly reading it and saying, hey, everybody read it. It was before Twitter turned to garbage. Media was still a way to amplify it. It's much harder now, so passing things along through social media has become a real problem. But at that moment, it was not—Jennie NashYeah.Jennifer SeniorSo that was totally luck. Also, I wonder if it was because I was suddenly writing something from in the first person, and my voice was just better that way. And I wouldn't have had, like, the courage, you know?Jennie NashYeah.Jennifer SeniorAnd also, you're a book critic, which is what I was at The Times. And you certainly are not writing from the first person. And as a columnist, you're not either.Jennie NashYeah.Jennifer SeniorSo, you know, those are very kind of constricted forms, and they're also not—there are certainly critics who win Pulitzers. I don't think I was good enough at it. I was good, but it was not good enough. I could name off the top of my head, like, so many critics who were—who are—who haven't even won anything yet. Like Dwight Garner really deserves one. Why has he not won a Pulitzer? He's, I think, the best writer—him and Sophie Gilbert, who keeps coming close. I don't get it, like, what the hell?Jennie NashDo you—as a—as a reader of other people's work, I know you—you mentioned Michael Ondaatje that you'd studied—study him. But do you just recognize when somebody else is on their game? Like, do you recognize the voice or the gloriousness of somebody else's work? Can you just be like, yeah, that...?Jennifer SeniorWell, Philip Roth, sentence for sentence. Martin Amis, even more so—I cannot get over the originality of each of his sentences and the wide vocabulary from which he recruits his words, and, like, maybe some of that is just being English. I think they just get better, kind of more comprehensive. They read more comprehensively. And I always tell people, if they want to improve their voice, they should read the Victorians, like that [unintelligible]. His also facility with metaphor, I don't think, is without equal. The thing is, I can't stand his fiction. I just find it repellent. But his criticism is bangers and his memoirs are great, so I love them.Jennie NashYeah.Jennifer SeniorSo I really—I read him very attentively, trying to think of, like, other people whose kind of...Jennie NashI guess I was—I was getting at more... like, genius recognizes genius, that con... that concept, like, when you know you can do this and write in this way from time to time anyway, you can pull it off.Jennifer SeniorYeah, genius as in—I wouldn't—we can't go there.Jennie NashWell, that's the—that's the cliché, right? But, like...Jennifer SeniorOh no, I know, I know. Game—game, game recognizes game.Jennie NashGame recognizes game is a better way of saying it. Like, do you see—that's actually what the phrase is. I don't know where I came up with genius, but...Jennifer SeniorNo, it's fine. You can stick anything in that template, you know—evil recognizes evil, I mean, you know, it's like a...Jennie NashYeah. Do you see it? Do you see it? Like, you can see it in other people?Jennifer SeniorSure. Oh yeah, I see it.Jennie NashYeah.Jennifer SeniorI mean, you're just talking about among my contemporaries, or just as it...Jennie NashJust like anything, like when you pick up a book or you read an article or even listen to a storytelling pack podcast, that sense of being in the hands of somebody who's on it.Jennifer SeniorYeah, I think that Jonathan Goldstein—I mean, I think that the—the Heavyweight Podcast, for sure, is something—and more than that, it's—it's storytelling structure, it's just that—I think that anybody who's a master at structure would just look at that show and be like, yeah, that show nails it each and every time.Jennie NashI've not listened, but I feel like I should end our time together. I would talk to you forever about this, but I always like to leave our listeners with something specific to reflect or practice or do. And is there anything related to metaphor or practicing, finding your voice, owning your voice, that you would suggest for—for folks? You've already suggested a lot.Jennifer SeniorRead the Victorians.Jennie NashAwesome. Any particular one that you would say start with?Jennifer SeniorYeah, you know what? I find Dickens rough sledding. I like his, you know, dear friend Wilkie Collins. I think No Name is one of the greatest books ever. I would read No Name.Jennie NashAmazing. And I will add, go read Jennifer's work. We'll link to a bunch of it in the show notes. Study her and—and watch what she does and learn what she does—that there it is, a master at work, and that's what I would suggest. So thank you for joining us and having this amazing discussion.Jennifer SeniorThis has been super fun.Jennie NashAnd for our listeners, until next time, stop playing small and write like it matters.NarratorThe Hashtag AmWriting Podcast is produced by Andrew Perrella. Our intro music, aptly titled Unemployed Monday, was written and played by Max Cohen. Andrew and Max were paid for their time and their creative output, because everyone deserves to be paid for their work. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit amwriting.substack.com/subscribe

Dr. Roger McFillin was interviewed by Renaud Beauchard from Tocsin Media—France's leading independent media platform with 30 million monthly views. In this unflinching conversation, Dr. Roger McFillin exposes what he calls a deliberate psychological operation on the American people: a system designed not to heal but to create lifelong customers, sever your connection to God, and make you dependent on medical authority for problems that were never diseases in the first place. The chemical imbalance theory? Born in pharmaceutical marketing rooms, not laboratories. ADHD? A label that stops investigation into the real causes poisoning our children. This isn't incompetence. It's an attack on human consciousness itself. And the first step to freedom is understanding exactly how they did it to you. Visit Center for Integrated Behavioral HealthDr. Roger McFillin / Radically Genuine WebsiteYouTube @RadicallyGenuineDr. Roger McFillin (@DrMcFillin) / XSubstack | Radically Genuine | Dr. Roger McFillinInstagram @radicallygenuineContact Radically GenuineConscious Clinician CollectivePLEASE SUPPORT OUR PARTNERS15% Off Pure Spectrum CBD (Code: RadicallyGenuine)10% off Lovetuner click here

Lisa welcomes Dr. Tina Ipe (MD, MPH), a transfusion-medicine hematologist and longevity expert, for a fascinating deep dive into therapeutic apheresis, autoimmune healing, telomere health, gut-driven immunity, GLP-1s, and why real prevention—not pills—creates lasting wellness. A must-listen for anyone seeking root-cause medicine, evidence-based longevity, and a fresh look at modern healthcare.     WEBSITE: https://www.regenmed.vip/     INSTAGRAM: https://www.instagram.com/drtinaipe_regenmedvip     FACEBOOK: https://www.facebook.com/profile.php?id=61556297771199     YOUTUBE:  https://www.youtube.com/@regenmedvip     EPISODE SPONSOR:  https://www.davidsburgers.com/     EPISODE SPONSOR:  https://marlsgate.com     LISA'S LINKS:     Lisa Fischer Said Academy:  https://lisafischersaid.com/academy/     Website:  lisafischersaid.com     For more information on group intermittent fasting  coaching with Lisa, email fasting@lisafischersaid.com     For more information on one-on-one or group health coaching with Lisa, email healthcoaching@lisafischersaid.com     Podcast produced by clantoncreative.com    

Menopause does not wait until you feel “old,” and it does not only live in your hot flashes. In this episode, I sit down with Dr. Lauren Streicher, one of the leading experts in menopause and sexual medicine, to talk about sexless relationships, painful penetration, and why so many women suffer in silence when solutions exist.We break down what really happens to your hormones, blood flow, muscles, nerves, and brain during perimenopause and postmenopause and how all of that shows up in your sex life. Dr. Streicher explains why painful sex is never something you should push through, why lubricants on their own rarely fix the problem, and why local vaginal estrogen is one of the safest and most misunderstood treatments in midlife.We also talk about access to care. Who helps you when your doctor shrugs, you live outside a big city, you are on Medicare, or you survived cancer and nobody ever mentioned sex in your follow up. Dr. Streicher shares what a real sexual medicine consult looks like, why pelvic floor physical therapy often changes both back pain and bedroom pain, and why there is no expiration date on your vagina, even after years of a dry spell.If you are in a sexless relationship, scared of hormones, or confused about where to start, this episode will give you language, options, and hope, plus a roadmap to Dr. Streicher's new deep dive audio course, “Come Again,” for women and professionals who want real data, not fear.In This Episode:00:00 – Welcome and show intro.00:32 – Why sexless relationships link to menopause.02:10 – Menopause is not an “old woman's” issue.04:20 – Sexual problems that start before menopause.06:30 – What a normal sexual response needs.09:25 – How estrogen loss affects sex and desire.12:40 – What happens in a sexual medicine consult.15:20 – Why doctors rarely refer to sexual medicine clinics.18:05 – Telehealth for menopause and its limits.21:30 – Why menopause never fully “ends.”25:05 – Painful sex and the need for accurate diagnosis.29:10 – Vaginal estrogen use, placement, and safety.33:15 – Partners, pain, and the “use it or lose it” myth.36:40 – Pelvic floor pain, SSRIs, and low libido.38:40 – Wrap up and closing message.Want a deeper look? Watch the full episode on YouTube for a more visual experience of today's discussion. This episode is best enjoyed on video—don't miss out!Karen Bigman, a Sexual Health Alliance Certified Sex Educator, Life, and Menopause Coach, tackles the often-taboo subject of sexuality with a straightforward and candid approach. We explore the intricacies of sex during perimenopause, post-menopause, and andropause, offering insights and support for all those experiencing these transformative phases.This podcast is not intended to give medical advice. Karen Bigman is not a medical professional. For any medical questions or issues, please visit your licensed medical provider.Looking for some fresh perspective on sex in midlife? You can find me here:Email: karen@taboototruth.comWebsite: https://www.taboototruth.com/Instagram: https://www.instagram.com/taboototruthYouTube: https://www.youtube.com/@taboototruthpodcastAbout the Guest:Lauren...

Mike Palmer returns to the Thanksgiving table to serve up a side of applied neuroscience. Powered by the recently released Gemini 3, he examines the "gratitude cocktail," a potent neurochemical mix of dopamine, serotonin, and oxytocin that mimics the effects of antidepressants and strengthens social bonds. Beyond the chemistry, Mike explores the psychological framework of The Gap and the Gain by Dan Sullivan and Dr. Benjamin Hardy. He explains how measuring progress against an ideal future creates unhappiness, while measuring against the past generates resilience and satisfaction. The conversation shifts from theory to practice, detailing why gratitude stories are more effective than rote lists and how specific "Notice, Think, Feel, Do" protocols rewire the brain. Mike also debunks the tryptophan myth, explaining how carbohydrates and compelling narratives—like football—actually drive the post-meal nap. Finally, he reflects on the origins of Trending in Education, shares updates on the new Trending in Higher Ed feed, and previews upcoming live events from SXSW EDU to Alexandria, Virginia. Key Takeaways The Gratitude Cocktail: Gratitude activates the brain's reward centers. Dopamine drives motivation, serotonin stabilizes mood similar to SSRIs, and oxytocin fosters trust and bonding. Mindset Shift: "Gap thinking" focuses on the distance between your actual self and an unreachable ideal, leading to burnout. "Gain thinking" measures your actual self against your past self, highlighting progress and abundance. Stories Over Lists: Rote gratitude lists often lead to mechanical habituation. Constructing gratitude narratives creates stronger neural pathways and emotional connections. The Science of the Nap: It isn't just the turkey. Tryptophan is a precursor to serotonin and melatonin, but the heavy carbohydrate load and the relief of social bonding are the real drivers of sleepiness. Podcast Expansion: Trending in Education is expanding its network with a dedicated Trending in Higher Ed feed to allow listeners to dive deeper into specific verticals. Why You Should Listen This episode moves beyond the platitudes of "giving thanks" to reveal the biological mechanisms that make gratitude a high-performance tool. If you find yourself doomscrolling or fixating on what you haven't achieved, the "Gap and The Gain" framework offers a practical method to reset your cognitive baseline. Mike connects these mental models to tangible brain health, offering a compelling argument for why gratitude is essential fuel for resilience and innovation. Like, follow, and subscribe to Trending in Education wherever you get your podcasts. Visit us at TrendinginEd.com for more. Time Stamps: 00:00 Introduction to the Neuroscience of Gratitude 00:49 The Science Behind Gratitude 02:01 Neurochemistry and Brain Health 04:01 The Gap and the Gain Framework 07:05 Practical Applications of Gratitude 09:18 Gratitude in Daily Life 13:48 Personal Stories and Reflections 19:49 Upcoming Projects and Gratitude 25:49 Conclusion and Final Thoughts

Week four of the Ending Well series lands right at the halfway mark. This episode is a look back over a three-year road (starting in 2022) of how God helped me fight inflammation, feel like myself again, and regain my "glow." This is not a weight-loss talk, not a quick-fix list, and not medical advice. It's a redemption story about healing from the inside out — spiritually, emotionally, and physically. "Beloved, I pray that you may prosper in all things and be in health, just as your soul prospers." — 3 John 1:2 Key Themes Redemption doesn't just cover salvation; it keeps working through sanctification and healing. Inflammation wasn't just a food problem — it was also a soul and nervous system problem. Real health change is slow, layered, and personal. Your timeline will not look like mine. The glow came as a byproduct of feeling better and living freer, not chasing beauty. Important Disclaimers This episode is descriptive, not prescriptive. Not medical advice. Always talk with a qualified professional for your situation. Do not try to do everything at once. This was a year of foundations plus a total three-year process. One percent better beats perfect overnight. The Story: How the Dominoes Fell 1. August 2022: Stepping Back From Fear-Driven "Crunchy" Culture I was drowning in rules, guilt, and constant fear of what might be harming me. The anxiety and striving became more toxic than the ingredients I was avoiding. First domino: I quit trying to do it all perfectly and started living with grace, budget reality, and peace. Lowering my standards for myself lowered my inflammation. "Come to me, all who are weary and burdened, and I will give you rest." — Matthew 11:28 2. October 2022: A Major Boundary With a Toxic Relationship I set a serious boundary with someone whose presence fueled self-hatred. Went no contact for about six months. The inner tape of shame and criticism began to quiet. I learned that giving up self-hatred is profoundly anti-inflammatory. Recommended resource mentioned: When to Walk Away by Gary Thomas (plus podcast interview) "Guard your heart above all else, for it determines the course of your life." — Proverbs 4:23 3. Early 2023: Changing How I Worked Out I stopped high-intensity workouts that were spiking cortisol daily. Switched to lifting heavy and slow, more functional strength training. Worked out less, recovered more. Energy improved, inflammation eased, confidence rose. Current favorite: Nourish Move Love workouts on YouTube. Big takeaway: exercise is a gift, not punishment. 4. February to May 2023: Going Gluten-Free and Cutting Back on Alcohol Grain Brain by Dr. David Perlmutter was a turning point. I tried going gluten-free (cold turkey, not ideal but it worked). Brain fog cleared, bloat dropped, inflammation noticeably reduced. Cutting alcohol alongside gluten made a huge difference. I don't need to understand every mechanism to honor what clearly helps my body. Reminder: everyone has a "thing" — gluten, dairy, sugar, alcohol, stress. Find yours with grace. 5. August 2023: Getting Off SSRIs After 15 Years A massive milestone with a full story in episode 267. For me, SSRIs were not helping inflammation or overall vitality anymore. The drop in facial inflammation from August to December was dramatic. I'm not shaming anyone on SSRIs — I was on them a long time. This was my path. "It is for freedom that Christ has set us free." — Galatians 5:1 What Actually Healed Me This part matters: the glow wasn't mainly from products. Lowering impossible expectations Creating boundaries Learning to like myself Getting out of fight-or-flight Moving my body in a gentler way Removing gluten and minimizing alcohol Walking in obedience even when it felt backwards Healing was spiritual and emotional first, physical second. "Be transformed by the renewing of your mind." — Romans 12:2 Simple "Glow Back" Skin Habits These are the practical, easy wins that helped the outside catch up to the inside. Dermaplaning at home Removes dead skin and peach fuzz. Skin care and makeup apply better. Big difference in glow and smoothness. Learn carefully through YouTube tutorials and use a quality razor. Stopping skin picking Picking was aggravating redness and irritation. I prayed about it and replaced the habit. New habit: brush my hair when the urge hits. Asking God for help in small things counts. Sponsor Spotlight: PreBorn A free ultrasound can double a mother's chance of choosing life. PreBorn offers ultrasounds plus ongoing support for mothers for up to two years. It costs 28 dollars to sponsor one ultrasound. Donate at preborn.com/speakeasy. Takeaways to Sit With If you're overwhelmed, start with one domino. God often heals from the root, not just the symptom. Your body listens to your beliefs. Peace, obedience, and self-kindness are deeply practical health tools. The goal isn't prettier; it's freer, healthier, and more whole. Reflective Questions What is one area where fear or perfectionism is inflaming your life? Who or what might need a boundary so you can heal? What small change feels like the next right step, not the whole staircase? How would your health shift if you treated yourself like someone God deeply loves? Closing Encouragement This glow-back story is really a "come back to life" story. It wasn't a sprint; it was obedience in baby steps. If you're in the thick of it today, don't despise the slow fade. God redeems years, bodies, minds, and hearts — and He's patient in the process. "He restores my soul." — Psalm 23:3

We know you're struggling. So we brought in the most soothing human on the planet-Therapy Jeff- to offer tips on how to get through Thanksgiving with your nasty family. In short, don't take the bait, find your family buddy, and if you are alone on the holiday, get yourself to a gay bar. Also, a woman who considers herself bad in bed wonders how she can find a "sex teacher." And, a woman wonders if she has her sub drink her pee while she is on SSRIs, will he ingest her meds? "Gobble" it up! Q@Savage.Love 206-302-2064 This episode is brought to you by Squarespace. They make it easy to build a website or blog. Give it a whirl at Squarespace.com/Savage and if you want to buy it, use the code Savage for a 10% off your first purchase. This episode is brought to you by Carafem, an abortion and reproductive healthcare provider that offers both in person care in Atlanta, Chicago, Washington DC and telehealth options for abortion pills by mail in 20 states. Carafem's team of licensed medical professionals provide personalized abortion care options focused on your needs, preferences, and values. Visit Carafem.org to learn more. This episode is brought to you by Feeld, a dating app where the open-minded can meet the like-minded. Download Feeld on the App Store or Google Play.

Antidepressants like SSRIs are strongly linked to hyponatremia, a dangerous drop in blood sodium that disrupts nerve and muscle function The risk is highest in the first two weeks of treatment, when sodium levels plummet to life-threatening lows that trigger confusion, seizures, or fainting Older adults, especially women over 80, are among the most vulnerable, with nearly 1 in 15 experiencing profound sodium loss after starting these drugs Symptoms of drug-induced low sodium often mimic worsening anxiety or depression, leading to misdiagnosis and unnecessary increases in medication Natural strategies like optimizing nutrition, restoring key vitamins and minerals, daily movement, sunlight exposure, and restful sleep offer safer ways to support mood and energy without creating sodium imbalances

Jordan Sather and Nate Prince deliver a packed episode of MAHA News, kicking off with the CDC's explosive website update acknowledging that claims of “no link” between vaccines and autism are not evidence-based, triggering absolute meltdown across legacy media, pharma loyalists, and blue-state health bureaucracies. The hosts track the political fallout, RFK Jr.'s direct role in ordering the change, and the wave of scientists now admitting long-ignored biologic mechanisms worth investigating. From Bhattacharya and Makary's blunt critiques of captured institutions to Robert Malone exposing the financial corruption inside the AAP and ACIP, the guys highlight a medical landscape finally cracking open. Jordan and Nate also dive into SSRIs, microbiome destruction, gut health, antibiotic overuse, and the soaring chronic-illness rates no one in the old regime wants to talk about. The episode closes with a fiery breakdown of SNAP as corporate welfare, revealing how billions in taxpayer dollars funnel straight into Coca-Cola, Frito-Lay, Walmart, and Big Food, while politicians pretend it's about “feeding the poor.” A fast, funny, and fiercely honest episode charting the scientific and political shifts reshaping U.S. health policy.

Overview Evelyn Eddy Shoop PMHNP-BC joins Psychedelics Today to share her journey from Division I athlete to psychiatric mental health nurse practitioner and psilocybin research participant. In this conversation, she explains how sports injuries, OCD, and intensive treatment led her into psychiatry and eventually into a psilocybin clinical trial at Yale. Her story weaves together lived experience, clinical training, and a call for more humane systems of care and better qualitative data in psychedelic science. Early Themes: Injury, OCD, and Choosing Psychiatry Early in the episode, Evelyn Eddy Shoop PMHNP-BC describes how multiple season ending injuries in college and serious mental health stressors in her family pushed her to rethink her life path. Originally pre vet, she stepped away from veterinary medicine after realizing she could not tolerate that environment. During a semester off for surgery and mental health, she completed intensive outpatient treatment and family therapy. That time showed her how powerful psychological work could be. It also reawakened a long standing curiosity about the brain, consciousness, and human experience. This led her to switch her major to psychology and later pursue psychiatric mental health nurse practitioner training at the University of Pennsylvania. At Penn, she felt supported academically and personally. Her interest in psychedelics grew as she realized that standard OCD treatments and high dose SSRIs were not giving her the level of functioning or happiness she knew was possible. Core Insights: Psilocybin Trials, Qualitative Data, and Clinical Skepticism In the middle of the episode, Eddy shares the story of finding a psilocybin trial on ClinicalTrials.gov just as she was about to start ketamine therapy. She received placebo first, then open label psilocybin, and describes the dosing day as one of the hardest days of her life, with benefits that emerged slowly over months through integration. She uses her experience to highlight why qualitative data matters. Numbers alone cannot capture the depth of a psychedelic journey or the slow unfolding of meaning over time. She argues that subjective stories, even difficult ones, are essential for clinicians, researchers, and policymakers. Key themes include: The central role of integration support in turning a crisis level session into lasting growth How trial environments on inpatient psychiatric units can feel like prison instead of healing spaces The limits of double blind placebo trials when participants become desperate for active treatment The need for more nuanced language around psychosis and psychedelic harms Eddy also addresses skepticism in psychiatry. Many providers fear substance induced psychosis and feel uneasy with medicines whose mechanisms are not fully understood. She suggests that more lived experience stories and careful education can help bridge that gap. Later Discussion and Takeaways In the later part of the episode, Eddy and Joe discuss harm reduction, ketamine risks, and how poorly designed systems can create harm even when the medicine itself is helpful. Eddy describes being treated as "just another psych patient" once the research team left for the day, including being denied basic comforts like headache relief after an emotionally intense session. She calls for: More humane hospital and research environments Required psychedelic education in psychiatric training Honest, nonjudgmental conversations about substance use with patients Stronger public education for students and festival communities Eddy also invites listeners in Wilmington, Delaware and nearby regions to connect if they need a psychiatric mental health nurse practitioner for psychedelic related research. She hopes to bring her lived experience and clinical skills into the emerging field as psilocybin and other treatments move toward approval. Frequently Asked Questions Who is Evelyn Eddy Shoop PMHNP-BC? She is a psychiatric mental health nurse practitioner trained at the University of Pennsylvania, a former Division I athlete, and a psilocybin trial participant who now advocates for more humane and data informed psychedelic care. What did Eddy learn from her psilocybin clinical trial experience? She learned that the hardest sessions can lead to deep change when integration support is strong and when there is time to unpack insights, rather than rushing to rate symptoms on a scale. Why does she care so much about qualitative data in psychedelic research? Eddy believes that numbers cannot capture the full human impact of psychedelic therapy. Stories show how people actually live with their disorders and integrate change, which is vital for ethical practice and policy. How does she view psychedelic harms and psychosis risk? She acknowledges real risks, especially for people with certain histories, but also notes that some psychotic experiences are not distressing. She calls for more precise language, better containers, and honest harm reduction education. What role does a psychiatric nurse practitioner like Evelyn play in psychedelic care? Practitioners like Evelyn can assess risk, prescribe within legal frameworks, provide preparation and integration, and help bridge the gap between traditional psychiatry and emerging psychedelic therapies. Psychedelic care is evolving fast, and this episode shows why voices like Evelyn Eddy Shoop PMHNP-BC are essential in the current psychedelic resurgence. Her blend of lived experience, clinical training, and critical thinking points toward a future where data and story, safety and possibility, can finally grow together.

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption. Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork. You'll Learn: • Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood • The exact signs that your dose is too strong, too weak, or in the Goldilocks zone • How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience • Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions • How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters • The link between mitochondrial health, fertility, libido, and long term anti aging strategies • How to track sleep optimization, HRV, and performance signals to dial in your personal protocol • The difference between aquarium grade dye and pharmaceutical grade formulations • Why genetic testing for G6PD deficiency is essential before higher dose experimentation Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair Thank you to our sponsors! -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 4:51 — History of methylene blue 7:38 — How methylene blue works 14:05 — Safety 17:53 — Dosing and timing guidelines 20:41 — Combining with red light therapy 22:41 — Quality and sourcing 23:17 — Dosing protocols 25:24 — Longevity and fertility effects 29:24 — Stacking options 32:10 — Common questions and FAQs 33:40 — Future research and wrap up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A groundbreaking blood test identified myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with up to 96% accuracy, using 3D genomic mapping to detect immune and metabolic disruptions in blood cells ME/CFS, a chronic, multisystem illness that can devastate daily life, affects an estimated 17 to 24 million people worldwide Research points to the gut-brain-immune axis as a key driver, linking post-infectious inflammation, leaky gut, and microbial imbalance Excess serotonin activity, often triggered by SSRIs, may worsen fatigue by slowing cellular energy production and increasing inflammation True recovery means restoring balance: calming the nervous system, repairing the gut, cutting inflammatory seed oils from the diet, and rebuilding cellular energy so the body can heal itself

Dylan Beynon, founder of Mindbloom, shares the deeply personal story behind building the first at-home ketamine therapy platform. After losing his mother and sister to severe mental illness, Dylan became determined to bring psychedelic medicine into mainstream healthcare. He explains the neuroscience of how ketamine creates neuroplasticity—allowing the brain to rewire itself—and why these treatments are showing 10x better outcomes than SSRIs. From navigating FDA breakthrough therapy designations to dismantling decades of stigma from Nixon-era drug policy, Dylan reveals how Mindbloom is democratizing access to treatments that were once only available in $5,000 in-person clinics. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Joe Moore sits down with Dr. Jason Konner, a longtime oncologist who recently left his full-time clinical role at Memorial Sloan Kettering to devote himself to the emerging intersection of cancer care and psychedelics. Dr Konner shares how, after more than two decades treating people, he hit a wall. The accumulated grief, constant exposure to death, and intensity of oncology left him deeply burned out, though he didn't have that language for it at the time. A chance moment in a yoga class, overhearing someone say "ayahuasca retreat" just before he was scheduled for hernia surgery, became the turning point. Within a week, he was in the jungle. That first week with ayahuasca, followed later by work with mushrooms, "absolutely transformed" his life. His fear of death lifted. The burnout he hadn't even recognized in himself was both revealed and relieved. When he returned to his practice, Konner describes feeling like he suddenly had a "superpower": he could stay present, connected, and compassionate with patients facing advanced disease without collapsing under the emotional weight. He and Joe explore what this third path looks like: not the classic binary between either hardening and distancing as self-protection, or staying open-hearted and getting shattered. Instead, psychedelics helped him hold deep relationship with patients and families while maintaining inner stability and meaning. This opened space for authentic conversations about spirituality, fear, grief, and what it means to live with (or die from) cancer. From there, Dr Konner zooms out to critique the broader oncology system: The lack of training and support for oncologists around their own emotional and existential load, How little space there is for relational work even though it's central to healing, Why many support groups and standard psychiatric approaches (like reflexively prescribing SSRIs) often miss the mark for people dealing with cancer, How caregivers, partners, family members, and others are deeply affected but rarely truly supported. Joe and Jason then dig into psychedelics and oncology as a frontier: easing existential distress in patients with terminal cancer, the neglected suffering of caregivers, the potential role of psychedelics in helping people relate differently to death, and what it might mean for ICU use, aggressive end-of-life interventions, and overall healthcare costs if more people could make decisions from a place of peace rather than terror. Dr Konner also shares a striking ovarian cancer case that hinted at powerful immune changes after shamanic work, and why he believes we need new research paradigms that can honor the integrity of retreat and ceremonial settings while still learning from them. Finally, he talks about his early-stage project, Psychedelic Oncology, and his hope that the first wave of change starts with clinicians themselves becoming more psychedelic-literate—and, where appropriate, doing their own inner work—so better options can eventually reach the people who need them most. Learn more - https://psychedeliconcology.com/

You may find the charges in this episode jarring: depression is not the result of a chemical imbalance, SSRIs aren't necessarily antidepressants, and the term you use for your mental health condition isn't scientifically valid. Sarah Fay, author of Pathological: The True Story of Six Misdiagnoses says it's dangerous to identify with your diagnosis because it's kind of made up and it blocks your path to recovery.A doctor told her she was “an anorexic” when Sarah was 12 years old, even though she didn't meet many of the criteria for anorexia. Sarah embraced the identity, taking on the behaviors and habits of a person with that eating disorder. Later in life, she was diagnosed with five more disorders, each time embracing the tag, all while her mental health deteriorated. Finally, another doctor said he didn't know what was the matter with her and that gave Sarah some peace and a chance to focus on feeling better. She saw her mental makeup as something not bound by the names of disorders in the Diagnostic and Statistical Manual used by mental health professionals. While she still takes meds and sees a therapist and a psychiatrist, Sarah has come to believe that everyone's focus needs to be on recovery rather than focusing on the limitations borne of terms she says are way too subjective and that don't stand up to scientific scrutiny.Thank you to all our listeners who support the show as monthly members of Maximum Fun.Check out our I'm Glad You're Here and Depresh Mode merchandise at the brand new merch website MaxFunStore.com!Hey, remember, you're part of Depresh Mode and we want to hear what you want to hear about. What guests and issues would you like to have covered in a future episode? Write us at depreshmode@maximumfun.org.Depresh Mode is on BlueSky, Instagram, Substack, and you can join our Preshies Facebook group. Help is available right away.The National Suicide Prevention Lifeline: 988 or 1-800-273-8255, 1-800-273-TALKCrisis Text Line: Text HOME to 741741.International suicide hotline numbers available here: https://www.opencounseling.com/suicide-hotlines

SSRI prescriptions are more common than ever—but how much do we really understand about how they work, their true efficacy, and their potential downsides? In this episode, we take a deep dive into the world of SSRIs, breaking down their mechanism of action and why their use has skyrocketed in recent years.   We unpack the growing concern around emotional blunting, a well-documented effect that can leave individuals feeling flat, disconnected, or lacking drive. You'll learn why the serotonin deficiency model falls short, what SSRIs actually do in the brain, and why so many people are placed on them without a root-cause approach. We also explore powerful food-as-medicine and lifestyle strategies proven to support mood: from low-glycemic eating and amino acid repletion, to gut health, micronutrients, and more. If you're looking to understand the full picture of SSRIs and discover evidence-backed alternatives for mental wellness, this episode is a must-listen.   Also in this episode:  Free Detox Webinar Naturally Nourished Black Friday Starts Now - use code SAVE10 for 10% off all supplements Naturally Nourished Academy Now Enrolling with Early Bird Pricing Through 12/31 Give the Gift of Wellness with Naturally Nourished Gift Cards Episode 160: Neurotransmitters Part 1 The Anti Anxiety Diet What is Serotonin Sleep Support Low vs. High Serotonin What are SSRIs? Fu-Ming Zhou, Yong Liang, Ramiro Salas, Lifen Zhang, Mariella De Biasi, and John A. Dani: "Corelease of Dopamine and Serotonin from Striatal Dopamine Terminals" SSRIs and Violent Crime Associations between selective serotonin reuptake inhibitors and violent crime in adolescents, young, and older adults - a Swedish register-based study - PubMed Selective Serotonin Reuptake Inhibitors and Violent Crime: A Cohort Study | PLOS Medicine How to Naturally Boost Serotonin and Support Mood Protein Whey Protect Magnesium Role of magnesium supplementation in the treatment of depression: A randomized clinical trial | PLOS One Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials Relax and Regulate MethylFolate Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial MethylComplete Movement Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials | The BMJ Gaba GabaCalm Keto for Mental Health The use of the ketogenic diet in the treatment of psychiatric disorders - PMC Probiotics as Natures Prozac Acceptability, Tolerability, and Estimates of Putative Treatment Effects of Probiotics as Adjunctive Treatment in Patients With Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychiatry Probiotic Challenge Protocol   Sponsors for this episode:  This episode is sponsored by FOND Bone Broth, your sous chef in a jar. FOND's bone broths and tallows are produced in small batches with premium ingredients from verified regenerative ranches. Their ingredients are synergistically paired for maximum absorption, nutritional benefit, and flavor. Use code ALIMILLERRD to save at https://fondbonebroth.com/ALIMILLERRD.   

In this episode of The Pediatric Pharmacist Review, we explore the phenomenon of seasonal affective disorder (SAD) and its relevance to children, adolescents, and families. Our guest, Tim Horton, is a seasoned psychiatric nurse‑practitioner (APRN, CNP) and founder of PeopleFirst Clinic in Woodbury, Minnesota, where he specializes in holistic, medication‑management and therapy‑integrated care for youth and adults. With his unique background in pediatric mental health, patient‑centered approaches, and collaborative provider work, Tim brings deep insight into how biological and environmental factors converge in seasonal depression—and what practical actions caregivers and clinicians can take to mitigate its impact. Key Discussion Points: Biological & Environmental Contributors: We unpack how changes in daylight exposure, circadian rhythm shifts, neurotransmitter variations (serotonin, melatonin), and geographic/seasonal factors contribute to SAD in children and teens. Lifestyle & Environmental Interventions: Tim and I discuss actionable strategies such as structured light‑exposure (dawn simulators, 10,000 lux boxes), daily outdoor activity, consistent sleep schedules, and nutritional supports (timing of meals, nutrient‑dense foods, healthy fats) to reduce symptom severity. Treatment Options & Efficacy: We review standard of care for SAD—starting with behavioral and lifestyle measures, then progressing to light therapy and pharmacologic treatment (SSRIs, SNRIs, augmentation) when needed, including considerations unique to pediatric populations. Vitamin D and Seasonal Depression: We examine the evidence linking vitamin D deficiency with increased SAD risk, discuss screening thresholds in younger patients, supplementation strategies, and how this fits into a broader preventive mindset. Preventive Measures Ahead of Winter: Tim outlines a pre‑winter readiness plan—adjusting indoor lighting, optimizing outdoor daylight exposure, establishing routine exercise, reinforcing healthy diet patterns, and monitoring early warning signs for a proactive response. Misconceptions and Under‑Recognition: We address common myths—such as SAD only occurring in extreme northern latitudes, or that “it's just the blues” and will self‑resolve—highlighting how under‑recognition in pediatric settings can delay helpful intervention. Resources & Links: Tim Horton LinkedIn: https://www.linkedin.com/in/tim-horton-248858359/ PeopleFirst Clinic: https://www.peoplefirstmn.com/

Today on AirTalk: the latest on the Epstein files; AI songs on the Billboard charts; the rise of the NFL; SSRIs and their impact on our sex drive; and the history of performance reviews. Today on AirTalk: What's in the Epstein files? (0:15) How is the music industry reacting to AI music? (14:26) A new book on the rise of the NFL (35:39) How are SSRIs affecting our sex drives? (51:17) The history of performance reviews (1:23:25) Visit www.preppi.com/LAist to receive a FREE Preppi Emergency Kit (with any purchase over $100) and be prepared for the next wildfire, earthquake or emergency

In this second part of the conversation, Dr. Scott Sherr returns to unpack one of the most fascinating compounds in modern mitochondrial medicine — methylene blue. Once used as the first FDA-approved antimicrobial drug, methylene blue is now being rediscovered as a powerful mitochondrial optimizer that helps the body both produce and detoxify energy at the same time. Dr. Sherr breaks down how it enhances ATP production, improves focus, endurance, and recovery, and even helps with travel fatigue and brain fog. He explains how methylene blue works at the cellular level, why quality and dosing matter, and clears up common myths and controversies — including its relationship with nitric oxide, serotonin, and safety concerns. Whether you're an athlete, entrepreneur, or anyone seeking more consistent, sustainable energy, this episode will help you understand how to use methylene blue safely and effectively to support performance and longevity. Follow Scott @drscottsherr Follow Chase @chase_chewning ----- 00:01 What Is Methylene Blue? — A 150-year-old molecule repurposed for mitochondrial health 02:13 From Blue Jeans to Medicine — The strange evolution from textile dye to the first FDA-approved drug 04:48 How It Works — The only compound that helps your cells both make and detoxify energy 06:52 Cyanide Antidote — How methylene blue restores mitochondrial function, even in toxin exposure 09:05 Real-World Results — Patient stories of fatigue recovery and performance optimization 11:34 Who It's For — From chronic illness to high performers seeking clean energy 13:31 Performance & Recovery Benefits — Endurance, anaerobic performance, and muscle recovery 16:18 Recovering Faster, Training Harder — How methylene blue enhances oxygen use and heart rate recovery 18:20 How to Cycle It — When and how often to take methylene blue for best results 20:31 Travel & Jet Lag Protocols — How methylene blue acts like oxygen at altitude and in airplanes 23:29 Methylene Blue for the Everyday Person — Calm, clean energy without the crash 26:33 The Importance of Quality & Purity — How to identify pharmaceutical-grade methylene blue and avoid contaminants 27:57 What to Look for in a Supplement — USP grade, certificates of analysis, and testing standards 30:51 Counterfeit Supplements & Amazon Scams — Why most methylene blue products don't meet purity claims 33:54 How to Take It — Solubility, timing, and why troches work best 36:09 Stacking with Red Light Therapy — Synergy between methylene blue and photobiomodulation 39:10 Dosage Guidelines — How to titrate, start low, and find your personal sweet spot 42:08 Who Should Avoid It — Blood pressure medications, SSRIs, pregnancy, and other contraindications 43:48 Clearing Up the Controversy — Why experts disagree on nitric oxide and serotonin effects. 45:23 The Nitric Oxide Debate — How dose determines whether methylene blue helps or hinders 47:51 Blue Brain Myths & Social Media Clickbait — The truth about the "blue brain" narrative 49:30 Final Thoughts — Safe dosing, cycling, and the future of mitochondrial optimization ----- Episode resources: Part one "The #1 Thing Killing Your Mitochondra & How to Stop it Today" Watch and subscribe on YouTube Learn more at Troscriptions.com/everforward

Segment 1 • Everyone sees it: the West is in the midst of social, moral, and spiritual collapse • But darkened hearts can't be fixed by legislature or cultural movements. • Real change starts “at the bottom” - with hearts transformed by Christ's gospel. Segment 2 • The Reformation rebuilt a crumbling civilization through faith, not force. • Oz Guinness calls this our “civilizational moment”—we're losing the foundation that built the modern world. • We won't be saved by “making America great again”— but by preaching Christ again. Segment 3 • Dr. Greg Gifford exposes the truth about SSRIs and the “chemical imbalance” myth. • Pills can mute pain but can't renew your mind or restore your soul. • Real transformation comes from God's work in us, not sedation. Segment 4 • New studies link antidepressants to alarming risks—violence, mania, even suicide. • SSRIs offer comfort without cure, masking spiritual problems with medical language. • True healing happens when the soul is renewed, not when the mind is medicated. ___ Thanks for listening! Wretched Radio would not be possible without the financial support of our Gospel Partners. If you would like to support Wretched Radio we would be extremely grateful. VISIT https://fortisinstitute.org/donate/ If you are already a Gospel Partner we couldn't be more thankful for you if we tried!

In this new Ask Me Anything episode, Dr. Will Cole and his clinical team - Andrea and Emily - answer your top wellness questions on everything from mental health to hormones and gut healing. They discuss what really happens when you taper off SSRIs, the hidden link between sugar and sore throats, why stress and restriction can stop your period, and whether it's possible to get off biologic medications after years of autoimmune flares. You'll also learn how inflammation, the gut-brain axis, and emotional stress shape your mental and physical well-being - plus practical tools to restore balance and build long-term resilience. For all links mentioned in this episode, visit http://www.drwillcole.com/podcastPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:For a limited time, Prolon is offering listeners 15% off site wide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit ProlonLife.com/WILLCOLE.As a listener ofThe Art of Being Well, you'll get 50% off your first subscription order of Get Joy's Freeze Dried Raw Dog Food plus two exclusive gifts: a free scoop and a 4oz bag of treats. Shop getjoyfood.com/willcole to fuel your dog's gut health and longevity.Visit gruns.co and use code WILLCOLE at checkout for up to 52% off your first order.Text ABW to 64000 to get twenty percent off all IQBAR products, plus FREE shipping. Message and data rates may apply.Timeline is offering 10% off your order of Mitopure. Go to timeline.com/WILLCOLE.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In episode 510 I chat with Dr Steven Poskar. Steven is a psychiatrist and clinical director of OCD NYC. He is also a member of the Scientific and Clinical Advisory Board of the International OCD Foundation. We discuss his therapy journey, myths and misconceptions around OCD medication, SSRIs for OCD, choosing an SSRI based on their side effect profiles, weaning off medication, augmenting medication for OCD with anti psychotics, glutamate medications for OCD, benzodiazepines, psychedelic drug trials for OCD, cannabis, some reasons why medication doesn't work, supplements, and much more. Hope it helps. Show notes: https://theocdstories.com/episode/steven-510 The podcast is made possible by NOCD. NOCD offers effective, convenient therapy available in the US and outside the US. To find out more about NOCD, their therapy plans and if they currently take your insurance head over to https://go.treatmyocd.com/theocdstories Join many other listeners getting our weekly emails. Never miss a podcast episode or update: https://theocdstories.com/newsletter 

Dr. Irwin Goldstein is one of America's leading sexual health physicians, a pioneer in the field, and the director of San Diego Sexual Medicine.In this episode, he breaks down his latest research into what's known as post-SSRI sexual dysfunction (PSSD)—a condition that's not uncommon but rarely discussed publicly.He's found that a class of antidepressants known as SSRIs can cause lasting physiological damage even after patients discontinue the medication—contrary to what many patients are told.“When they stop the medicine, the usual teaching is that everyone returns to their pre-medication sexual function, and that's not what we're seeing in our sexual health clinic here,” Dr. Goldstein says.His recent research showed that SSRIs can cause structural damage to genital tissue as well as many other physiological problems, like genital numbness, erectile dysfunction, and loss of libido. These problems persist long-term after discontinuing SSRI antidepressants.“It's kind of an awful thing, and it doesn't go away,” Dr. Goldstein says. “These individuals in my clinic who have been given the medicines: Our youngest is age 11. They'll never experience what one would otherwise consider a normal sexual life.”Dr. Goldstein holds a degree in engineering from Brown University and a medical degree from McGill University in Montreal. He is credited with advancing the study and treatment of both male and female sexual dysfunctions and has authored more than 360 academic publications in the field.Views expressed in this video are opinions of the host and the guest, and do not necessarily reflect the views of The Epoch Times.

Listen to the full episode: https://youtu.be/trGbcAqF2dA?si=qG5E_F-gP4x8qQhp  Why do you wake up at 3:30 AM and can't fall back asleep? In this Fitness Friday episode on the Habits and Hustle podcast, Michael Breus, the Sleep Doctor, says it's not your fault.  We unpack the science of why everyone wakes up between 1-3 AM, the shocking Alzheimer's connection to Benadryl, and why CBN (not CBD) is the cannabis compound that actually helps sleep. Plus: the truth about melatonin, why magnesium beats most sleep aids, and the supplement deficiencies sabotaging your rest. Dr. Michael Breus is a clinical psychologist and one of only 168 psychologists in the world board-certified in sleep medicine. Known as "The Sleep Doctor," he's the author of five books including Sleep, Drink, Breathe and has treated celebrities from Carson Daly to Paris Hilton to DJ Steve Aoki. What we discuss: Why every human wakes up between 1-3 AM The 4-7-8 breathing technique Navy SEALs use to lower heart rate below 60 Yoga nidra gives you 20 minutes of sleep benefit for every hour of rest Regular Benadryl/ZzzQuil use directly linked to Alzheimer's disease CBD does nothing for sleep. What actually reduces nighttime awakenings The three deficiencies destroying your sleep Why melatonin affects birth control, SSRIs, and is NOT for children Natural alternatives to melatonin Thank you to our sponsor: Therasage: Head over to therasage.com and use code Be Bold for 15% off  Air Doctor: Go to airdoctorpro.com and use promo code HUSTLE for up to $300 off and a 3-year warranty on air purifiers. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Momentous: Shop this link and use code Jen for 20% off  Manna Vitality: Visit mannavitality.com and use code JENNIFER20 for 20% off your order  Prolon: Get 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit https://prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Find more from Dr. Michael Breus: Website:https://sleepdoctor.com/  Books: https://sleepdoctor.com/books  Find more from Jen: Website: https://www.jennifercohen.com/ Instagram: @therealjencohen   Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagements

On this episode of The Adam and Dr. Drew Show, Adam kicks things off venting about people who constantly try to scare others with negative health claims — like peanuts being bad for you. The guys discuss how pharmaceuticals and SSRIs have devastated today's younger generation, and Adam reads an excerpt from his book In 50 Years We'll All Be Chicks about the rise of peanut allergies. They wrap up by reacting to a recent clip of Karine Jean-Pierre on The Late Show with Stephen Colbert.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.