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3 episodes with showpdf
3 episodes with showpdf
2 episodes with showpdf
2 episodes with showpdf
2 episodes with showpdf
2 episodes with showpdf
4 episodes with showpdf
2 episodes with showpdf
2 episodes with showpdf
Prof. Dr. Kampf kritisierte im Herbst 2021 im Wissenschaftsmagazin "The Lancet" die Stigmatisierung Ungeimpfter. Sein neues Buch fasst die Reaktionen auf diesen Brief zusammen und thematisiert die Toleranz in der Wissenschaft. Artikel: https://blog.bastian-barucker.de/buchauszug-toleranz-in-der-wissenschaft/ Sein neues Buch: https://buchshop.bod.de/die-stigmatisierung-der-ungeimpften-waehrend-covid-19-guenter-kampf-9783758351488 Sein Brief im Lancet: https://www.thelancet.com/action/showPdf?pii=S0140-6736%2821%2902243-1 Meine Arbeit unterstützen: https://blog.bastian-barucker.de/unterstuetzung/ Eingesprochen von Adam Nümm: https://zeitenwechsel.org
A microbicide for Neisseria gonorrhoeae? In this episode Luis is joined by Dr. María Rendón from the University of Arizona. Dr. Rendón joins the podcast to talk about a novel microbicide that was developed which has activity against N. gonorrhoeae . How does it work? Does it affect commensal Neisseria? What about methylation signatures? Tune in to learn more about this microbicide.Link to articles referenced in episode:http://microbialcell.com/researcharticles/2019a-so-microbial-cell/https://www.cell.com/action/showPdf?pii=S1931-3128%2819%2930347-6Link to study: https://journals.asm.org/doi/abs/10.1128/aac.00794-24?doi=10.1128/aac.00794-24Questions? Feedback? Send those to letstalkmicro@outlook.comWant to support the podcast? Here's how:Venmo: https://venmo.com/u/letstalkmicroBuy me a Ko-fi: https://ko-fi.com/letstalkmicro
In this episode of the What's Work Got To Do With It? podcast, OHSU School of Nursing and OccHealthSci Assistant Professor Andrew McHill discusses findings from a recent study that looked at the impact of a high-fat diet on the body's ability to adjust to time changes like daylight saving. According to Dr. McHill, based on the study's findings, individuals who eat a high-fat dies may expect their bodies to have a harder time adjusting to time changes like daylight saving or jet lag. Download the article: https://www.cell.com/action/showPdf?pii=S2589-0042%2824%2901902-3
This one is an art episode, but also a murder episode and also a madness episode. Artist Richard Dadd's life story is quite sad, but his art remained consistently good, even at the lowest points in his life. Research: Boyce, Niall. “Ehibition: Richard Dadd—Painting From His Mind's Eye.” The Lacet. January 22, 2011. https://www.thelancet.com/action/showPdf?pii=S0140-6736%2811%2960065-2 “The Cobham Park Murder.” The Examiner. Sept 9, 1843. https://www.newspapers.com/image/388277729/?match=1&terms=richard%20dadd Dadd, Richard. “Halt in the Desert.” British Museum. https://www.britishmuseum.org/collection/object/P_1987-0411-9#object-detail-data Dadd, Richard. “The Fairy Feller's Master Stroke.” Tate Museum. https://www.tate.org.uk/art/artworks/dadd-the-fairy-fellers-master-stroke-t00598 Hall, Samuel Carter. “The Book of British Ballads.” J. How. 1842. Accessed online: https://books.google.com/books?id=Tm8sFMykgdgC&source=gbs_navlinks_s Hare, Edward. “Creativity And Mental Illness.” British Medical Journal (Clinical Research Edition), vol. 295, no. 6613, 1987, pp. 1587–89. JSTOR, http://www.jstor.org/stable/29529224 Huddleston, S., & Russell, G. A. (2015). Richard Dadd: The Patient, the Artist, and the “Face of Madness.” Journal of the History of the Neurosciences, 24(3), 213–228. https://doi.org/10.1080/0964704X.2013.849077 Kerley, P “Richard Dadd: The art of a 'criminal lunatic' murderer.” BBC News Magazine. Nov. 13, 2015. https://www.bbc.com/news/magazine-34722937 Lippincott, Louise. “Murder and the Fine Arts; Or, a Reassessment of Richard Dadd.” The J. Paul Getty Museum Journal, vol. 16, 1988, pp. 75–94. JSTOR, http://www.jstor.org/stable/4166579 Munn, Geoffrey. “New Light on Dadd: George Bailey (1821–1898)by Richard Dadd (1817–86).” The British Art Journal, vol. 24, no. 2, 2023, pp. 75–76. JSTOR, https://www.jstor.org/stable/48760525 “The Murder of Mr. Dadd – Apprehension of Richard Dadd.” Chester Chronicle, and Chester and North Wales General Advertiser. Sept. 15, 1843. https://www.newspapers.com/image/793241104/?match=1&terms=richard%20dadd “The Parricide at Cobham Park.” Essex, Herts and Kent Mercury. Sept 19, 1843. https://www.newspapers.com/image/933363283/?match=1&terms=richard%20dadd “Richard Dadd.” Getty Museum. https://www.getty.edu/art/collection/person/103JS7 “Richard Dadd painting to return to Bethlem Hospital after 170 years.” BBC. January 6, 2023. https://www.bbc.com/news/uk-england-london-64155941 “The ‘Satanic' in Newspaper Literature.” Leicester Chronicle. Sept. 16, 1843. https://www.newspapers.com/image/816920892/?match=1&terms=richard%20dadd Seifert, Ruth, et al. “Mad, Bad or Sad? Prison and Psychiatric Illness.” RSA Journal, vol. 147, no. 5490, 1999, pp. 112–21. JSTOR, http://www.jstor.org/stable/41378810 "'Sketch of an Idea for Crazy Jane' by Richard Dadd.” Bethlem Museum of the Mind. https://museumofthemind.org.uk/blog/sketch-of-an-idea-for-crazy-jane-by-richard-dadd “Top 20 finds on the Antiques Roadshow.” BBC. Sept. 19, 2017. https://www.bbc.co.uk/mediacentre/mediapacks/antiques-roadshow-40/valuable Tromans, Nicholas. “Richard Dadd: the Artist and the Asylum,” D.A.P./Tate. 2011. See omnystudio.com/listener for privacy information.
Do an internet search for “fertility supplements”... yeah, maybe don't. You can easily get overwhelmed by an avalanche of supplement information and advice when you're trying to conceive. But … what supplements can truly help you get pregnant faster? And whose advice can you trust? Supplements and “super foods” go in and out of fashion faster than bangs-or-no-bangs, and the latest “hot” supplement is CoQ10. Coenzyme Q10 is an antioxidant our bodies make naturally, or that we can get from dietary sources. However, as with anything you add to your body in a concentrated fashion like a supplement, you need to know the benefits AND the risks. In this episode, Dr. Shahine is separating fact from fiction when it comes to the supplement CoQ10 and your fertility. There are some benefits to CoQ10, such as improving egg quality and sperm parameters, but it's important to understand the evidence is still not definitive. This episode will arm you with information you can take back to your healthcare provider. Then you'll know what questions to ask to get a supplement regimen that is most beneficial to you. In this episode you'll hear: [2:04] What is CoQ10? [3:41] How CoQ10 works [4:45] Possible side effects [5:47] Evidence of CoQ10 for female fertility [14:55] Evidence of CoQ10 for male factor [17:46] What Dr. Shahine tells her own patients about CoQ10 Resources mentioned: Review article of nutrients for IVF, Hart et al. 2024 RBMO www.rbmojournal.com/action/showPdf?pii=S1472-6483%2823%2900869-6 Review article CoQ10 info, Rodriguez-Valera 2021 J Molecular Science www.mdpi.com/1422-0067/22/17/9541 CoQ10 levels decrease in levels with age, Ben-Meir et al. 2015 Fert Stert www.sciencedirect.com/science/article/pii/S001502821500374X Animal studies showing improved egg and embryo quality with CoQ10 supplementation journals.sagepub.com/doi/full/10.4137/CMRH.S14681 Randomized controlled trial CoQ10 aneuploidy rates in women doing IVF/ICSI, Bentov et al. 2014 Sage journals.sagepub.com/doi/full/10.4137/CMRH.S14681 Review article on antioxidants (including CoQ10) and male fertility, Kaltsas et al. Medicine 2023 www.mdpi.com/1648-9144/59/10/1769 Sperm motility improved in men given CoQ10, Balercia, G.2009 Fert Stert www.fertstert.org/article/S0015-0282(08)00487-1/fulltext Stay Up to Date in Fertility News and Events: Weekly Newsletter Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books
L'Intelligenza Artificiale è più brava di te a scovare le MENZOGNE! Ma questo apre alcuni problemi, etici, sociali e cognitivi. Parliamone! Lo studio citato: https://www.cell.com/action/showPdf?pii=S2589-0042%2824%2901426-3 Un articolo interessante: https://www.technologyreview.com/2024/07/05/1094703/ai-lie-detectors-are-better-than-humans-at-spotting-lies/ ⬇⬇⬇SOTTO TROVI INFORMAZIONI IMPORTANTI⬇⬇ Abbonati al canale da 0,99 al mese ➤➤➤ https://bit.ly/memberdufer I prossimi eventi dal vivo ➤➤➤ https://www.dailycogito.com/eventi Scopri la nostra scuola di filosofia ➤➤➤ https://www.cogitoacademy.it/ Impara ad argomentare bene ➤➤➤ https://bit.ly/3Pgepqz Prendi in mano la tua vita grazie a PsicoStoici ➤➤➤ https://bit.ly/45JbmxX Il mio ultimo libro per Feltrinelli ➤➤➤ https://amzn.to/3OY4Xca La newsletter gratuita ➤➤➤ http://eepurl.com/c-LKfz Daily Cogito su Spotify ➤➤➤ http://bit.ly/DailySpoty Tutti i miei libri ➤➤➤ https://www.dailycogito.com/libri/ Il nostro podcast è sostenuto da NordVPN ➤➤➤ https://nordvpn.com/dufer #intelligenzaartificiale #rickdufer #etica INSTAGRAM: https://instagram.com/rickdufer INSTAGRAM di Daily Cogito: https://instagram.com/dailycogito TELEGRAM: http://bit.ly/DuFerTelegram FACEBOOK: http://bit.ly/duferfb LINKEDIN: https://www.linkedin.com/pub/riccardo-dal-ferro/31/845/b14 -------------------------------------------------------------------------------------------- Chi sono io: https://www.dailycogito.com/rick-dufer/ -------------------------------------------------------------------------------------------- La musica della sigla è tratta da Epidemic Sound (Ace-High, "Splasher"): https://login.epidemicsound.com/ - la voce della sigla è di ELIO BIFFI Learn more about your ad choices. Visit megaphone.fm/adchoices
#099 Rebroadcast In this special re-release episode, Melissa and Jam dive deep into the world of Vitamin A (retinol) and its role in anti-aging skincare. They revisit a popular episode that explores whether anti-aging products genuinely work. The hosts break down the scientific functions of the skin, the impact of UV radiation, and the importance of sunscreen. They also discuss how retinoids (vitamin A) can help repair and maintain the skin's structure, backed by peer-reviewed studies. This episode is a blend of chemistry, practical skincare tips, and personal anecdotes. 00:00 Introduction to Vitamin A and Anti-Aging 00:10 Revisiting the Anti-Aging Episode 00:36 Personal Reflections on Skincare 02:06 Acknowledging Influences and Inspirations 04:57 Understanding Skin and Aging 07:55 The Role of Fibroblasts and Proteins 10:55 Impact of UV Rays on Skin Aging 14:10 Importance of Sunscreen 15:56 Retinoids: The Gold Standard in Anti-Aging 19:50 Retinoid Study Results 20:31 Retinoids: The Antidote to Sun Damage 21:34 The Importance of Sunscreen 23:45 Understanding Skin Structure 26:08 How Retinoids Work 29:44 Fun Facts and Warnings About Retinoids 34:02 Personal Stories and Reflections 38:33 Conclusion and Listener Engagement References from this episode https://www.jidonline.org/action/showPdf?pii=S0022-202X%2815%2940798-5 https://www.jidonline.org/article/S0022-202X(15)40798-5/fulltext https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791161/#:~:text=Retinoids%20are%20also%20commonly%20known,and%20promotes%20angiogenesis%20%5B13%5D https://www.acs.org/content/acs/en/molecule-of-the-week/archive/v/vitamin-a.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791161/#:~:text=Firstly%2C%20retinol%20is%20converted%20to,to%20the%20retinoic%20acid%20receptors.&text=Retinol%20concentration%20in%20the%20cosmetic,the%20oxidized%20form%20of%20retinol https://youtu.be/grxmyM7EuDk https://pubs.acs.org/doi/10.1021/acsomega.0c02102 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790843/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/#R60 https://cen.acs.org/articles/95/i10/Periodic-graphics-anti-aging-creams.html https://www.acs.org/content/acs/en/pressroom/reactions/videos/2017/are-anti-aging-creams-legit.html Thanks to our monthly supporters Jessie Reder Ciara Linville J0HNTR0Y Jeannette Napoleon Cullyn R Erica Bee Elizabeth P Sarah Moar Rachel Reina Letila Katrina Barnum-Huckins Suzanne Phillips Venus Rebholz Lyn Stubblefield Jacob Taber Brian Kimball Emerson Woodhall Kristina Gotfredsen Timothy Parker Steven Boyles Chris Skupien Chelsea B Bri McAllister Avishai Barnoy Hunter Reardon ★ Support this podcast on Patreon ★ Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife
Essa foi uma semana de recomeços para quem vive no RS. Apesar do barulho dos helicópteros em alguns momentos do episódio, estamos retornando com os nossos programas regulares. Neste episódio do Journal Club, trazemos os seguintes artigos para vocês:1. Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula A Randomized Clinical Trial - Resultados do Neurodesenvolvimento de Prematuros Extremos Alimentados com Leite Humano de Banco ou Fórmula de Prematuro - Um Ensaio Clínico RandomizadoExiste diferenças em relação ao neurodesenvolvimento com dois anos de idade, quando comparamos uso de leite humano de banco e fórmula para prematuros?Descubra em: https://jamanetwork.com/journals/jama/article-abstract/2814657?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jama.2023.27693 2. Dextrose gel prophylaxis for neonatal hypoglycaemia and neurocognitive function at early school age: a randomised dosage trial - Profilaxia com gel de dextrose para hipoglicemia neonatal e função neurocognitiva em idade escolar precoce: um ensaio clínico randomizado O uso da profilaxia para hipoglicemia utilizando gel de dextrose é capaz de reduzir prejuízos ao desenvolvimento neuropsicomotor?Disponível em: https://fn.bmj.com/content/early/2024/02/12/archdischild-2023-3264523. Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomized controlled trial - Efeito da fortificação à base de leite humano em prematuros extremos alimentados exclusivamente com leite materno: ensaio clínico randomizado e controladoVale a pena investir no fortificante de leite materno a base de leite humano? Descubra em: https://www.thelancet.com/action/showPdf?pii=S2589-5370%2823%2900552-7 4. Randomised study of a new inline respiratory function monitor (Juno) to improve mask seal and delivered ventilation with neonatal manikins - Estudo randomizado de um novo monitor de função respiratória (Juno) para melhorar a vedação da máscara e a ventilação em manequins neonataisQue a vedação da máscara é importante para a eficácia da VPP na reanimação neonatal não há dúvidas. Esse artigo mostra formas de detectar a vedação e corrigir a técnica em manequins. Disponível em: https://fn.bmj.com/content/early/2024/02/09/archdischild-2023-326256 Não esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Se estiver gostando do nosso Podcast, por favor deixe sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org
Send us a Text Message.Simon returns with another paper of interest and only a mild case of crushing guilt at loosing an entire episode and having an existential impostor syndrome driven personal crisis. Yay autism.Which is todays topic, can a fish have autism and if so, what does that tell us about people, dopamine and our own development. Papers as ever:https://ajp.amjpathol.org/action/showPdf?pii=S0002-9440%2824%2900086-5https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3146https://pubmed.ncbi.nlm.nih.gov/38767699/https://theconversation.com/why-autistic-people-must-be-at-the-heart-of-autism-research-228543 As ever we thank you, our loyal listeners for sticking with us. We would love to hear from you and our Twitter is open @AtypicalThePod for messages and comments. Have a topic you would like us to cover, or do you fancy joining us for a natter, maybe tell us about your area of interest or expertise and share these things with everyone. We would also recommend our friend The Autistic Women for another great view on living with autism and our friends at the All Bets are Off podcast who cover addiction.
Welcome to another episode where we dive deep into the fascinating world of Interventional Endoscopy. This time, I have the privilege of interviewing Dr. Amandeep K. Shergill, a renowned figure in the field of Gastroenterology. As the Chief of GI at the Veterans Affairs Medical Center in San Francisco and a professor of medicine at the University of California, San Francisco (UCSF), Dr. Shergill has made significant contributions to the field of medicine and in this episode, we delve into her pioneering work on ergonomics in endoscopy. Dr. Shergill shares her insights on the importance of ergonomics in improving physician comfort, and overall avoidance of injury. She also discusses the challenges faced in this evolving field and her vision for the future of endoscopy. Join us for this engaging conversation that promises to broadens your understanding of ergonomics whether you're an endoscopist (or an aspiring one), a medical student, or just someone interested in the progress of medical science. Make sure to tune in and discover the trailblazing work of Dr. Shergill, a true innovator changing the face of endoscopy. For more resources about ergonomics in endoscopy please refer to these links: https://www.asge.org/docs/default-source/guidelines/asge-guideline-on-the-role-of-ergonomics-summary.pdf?sfvrsn=702fe5c_1 https://www.asge.org/home/resources/publications/practical-solutions/practical-solutions-october-ergonomics-for-endoscopy-team https://www.giejournal.org/action/showPdf?pii=S0016-5107%2823%2902578-6
Watch Jaime Seltzer and other experts share their expertise at the INIM Conference 2024 on May 10, 2024. Register here: https://www.nova.edu/nim/events.html In this episode, Haylie Pomroy and Jaime Seltzer discuss the challenges faced by patients with myalgic encephalomyelitis (ME/CFS) and Post-COVID Syndrome (or Long COVID) in obtaining proper diagnosis and treatment due to the lack of understanding among medical providers. Together, they emphasize the importance of patient-reported symptoms in diagnosing ME/CFS accurately and discuss efforts by Jaime's organization, ME Action, to improve clinical care and education. Don't miss out on this episode as Jaime and Haylie explain the complexities of post-viral conditions like ME/CFS and Long Covid, including the relationship between viral damage, immune responses, and genetic factors. Explore the various sources of symptoms in these conditions and the need for personalized approaches to address them effectively. Resources Mentioned: Mayo Clinic Paper, “Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome”: https://www.mayoclinicproceedings.org/action/showPdf?pii=S0025-6196%2823%2900402-0 Pacing and Management Guides: https://www.meaction.net/resource/pacing-and-management-guide/ Neuroinflammation Research Review (2019) by Jaime Seltzer: http://www.meaction.net/wp-content/uploads/2019/06/19_MEA_Revised_2019_Research_Summary_190610.pdf Subscribe to the MEAction Newsletter: https://www.meaction.net/subscribe/ Donate to the MEAction Network: meaction.net/donate Jaime Seltzer is the Director of Scientific and Medical Outreach at ME Action, a nonprofit advocating for those with chronic illnesses. She bridges communication between healthcare, government, and research sectors, representing ME Action globally. Additionally, Jaime collaborates with institutions like Stanford Medicine and Mayo Clinic Rochester on post-infectious chronic diseases research. She brings personal insight to her work as someone living with ME/CFS. LinkedIn: https://www.linkedin.com/in/jaime-seltzer-b23abb14/ Twitter: https://twitter.com/exceedhergrasp1 Website: https://www.meaction.net/ —------------------------------------------------------------------------------------------------ Thank you for tuning in to the Hope and Help For Fatigue and Chronic Illness Podcast. Sign up today for our newsletter.
Watch out for polar bears with me as Devon Manik, the Inuk youth resurrecting the ancient art of dog sledding in Resolute Bay, feeds his sled dogs. Explore the dark history of the killing of Inuit sled dogs and enjoy Devon's fiery passion for hip hop and Narwhal skin. Credits: The show is written and recorded by me, Danielle Paradis, audio edited by Jesse Andrushko and Danielle Paradis, produced by Mark Blackburn, theme music by Angela Amraualik, cover art by Anne Qammaniq-Hellwig You can email me, dparadis@aptn.ca Learn more about The Place That Thaws: https://www.aptnnews.ca/theplacethatthaws/ Hear more APTN News podcasts: https://www.aptnnews.ca/podcasts/ If you like this podcast, consider donating to support Indigenous news here: https://www.aptnnews.ca/contribute/ Sources for this episode: Morris Animal Foundation https://www.morrisanimalfoundation.org/article/populations-tumbling-researchers-race-understand-effects-climate-change-musk-oxen Projections of a sea ice free arctic https://www.nature.com/articles/s41467-023-38511-8 Climate anxiety in youth https://www.thelancet.com/action/showPdf?pii=S2542-5196%2821%2900278-3 Qikitani Truth Commission https://www.qtcommission.ca/en/key-findings
In this 211th in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we talk about the state of the world through an evolutionary lens.In this episode, we discuss Winter and seasonality, before a longer discussion of overfitting, shoe-horning, and straight-jacketing. How do models, collusion, and Occam's Razor contribute to how we understand the world? Why are generalists better situated to interpret complexity than are specialists? Then: how good is the science behind the major paper out of The Lancet that assures us that we should not be eating red meat? Answer: not very. Finally, we discuss the orcas who were trapped in sea ice off of Japan, and what it means to be an orca (including mention of the grandmother hypothesis).*****Our sponsors:MDHearing: To get our $397 when you buy a PAIR offer, head to Shopmdhearing.com and use code DARKHORSE. Helix: Excellent, sleep-enhancing, American-made mattresses. Go to www.HelixSleep.com/DarkHorse and use code HELIXPARTNER20 to get up to 20% of all mattress orders AND 2 free pillows.ARMRA: Colostrum is our first food, and can help restore your health and resilience as an adult. Go to www.tryarmra.com/DARKHORSE to get 15% off your first order.*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com/Heather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://a.co/d/dunx3atCheck out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:The Emperor of Scent by Chandler Burr (about Luca Turin): https://www.amazon.com/Emperor-Scent-Story-Perfume-Obsession/dp/0375759816 Willett et al 2019. Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems. Lancet 393, 447–492: https://www.thelancet.com/action/showPdf?pii=S0140-6736%2818%2931788-4Stanton 2024. Unacceptable use of substandard metrics in policy decisions which mandate large reductions in animal-source foods. Npj Science of Food 8(10): https://www.nature.com/articles/s41538-024-00249-yStanton et al 2022. 36-fold higher estimate of deaths attributable to red meat intake in GBD 2019: is this reliable?. The Lancet, 399(10332), pp.e23-e26.: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00311-7/fulltextSupport the show
In dieser abschließenden Episode des Themenmonats sprechen wir mit einem Landzahnarzt über die Versorgungsengpässe der Dentalmedizin und haben uns mit einer Landapothekerin verabredet, die von ihrer Lebenswirklichkeit berichtet.Niko Schulz erzählt über unser gemeinsames Projekt mit dem Namen „Auf Sicht Fahren“, das zum Ziel hatte, die augenheilkundliche Versorgung auf dem Land auf neue Beine zu stellen und aus dem sogar ein Kinofilm gleichen Namens entstand. https://vimeo.com/manage/videos/695760981/855e333a01Die Reise führt aber aber zunächst zurück ins südliche Sachsen-Anhalt. In der der Lutherstadt Eisleben, westlich von Halle, arbeiten die HealthCare Futurists zusammen mit der Universität Halle und zwei Pflegeheimen seit April 2023 an dem Modell der digitalen Residenzpraxis, kurz DRP, die in Pflegeheimen die digitale Verbindung zu fachärztlicher Behandlung aufbaut.Wir sind mit Silke Otto, der Geschäftsführerin des Lutherhofs verabredet und mit Prof. Patrick Jahn treffen wir einen alten Bekannten wieder. Die digitale Residenzpraxis ist ein Beispiel dafür, wie die Aufgaben der Pflege zukünftig aussehen können.Wir ziehen ein ausführliches Fazit unserer Landpartie, unsere Odyssee auf dem großen Meer des Deutschen Gesundheitswesens.Wir bedanken uns bei allen Dramatis PersonaeUwe BossertProf. Dr. Dr. Christian DierksDr. Oliver TiedgeDr. Stefan GramlichDr. Winfried KöstersWaldemar SchmidtProf. Dr. Patrick JahnSilke Otto Dr. Wolfang von Meissner Nico SchulzProf. Dr. Sven StreiProf. Dr. Frank MontgomeryProf. Dr. Karl LauterbachJohannes RothmundDr. Dirk LeisenbergUrsula SchlievenbroichDr. Irmgard StipplerProf. Dr. Hayo Krömer Prof. Dr. Jochen Werne Prof. Dr. Hagen ThiemDr. Helmut HildebrandtBernadette KlappeDanke an mein Produktionsteam Sarah Tirtey, Jonas van Hagen, Artur Olesch, Sascha Hömske, Micha Rosenkranz und Christina Mailänder.Ganz spezieller Dank geht an Jürgen Zurheide, der mich ein wenig in das journalistische Handwerk hinein schauen ließ und mir ein paar große Türen öffnete.Ein paar weiterführende Links https://lillian-care.de/ https://www.zeit.de/arbeit/2023-12/aerzte-jobausstieg-umfrage-gesundheitsminister https://www.mcpdigitalhealth.org/action/showPdf?pii=S2949-7612%2823%2900073-1 https://www.forbes.com/sites/katiejennings/2023/11/15/an-ai-doctor-in-a-box-coming-to-a-mall-near-you/?sh=7ac4fd574284 https://www.swr.de/swraktuell/rheinland-pfalz/mainz/medizin-studentin-in-mainz-will-landaerztin-werden-100.html https://www.fr.de/panorama/wenige-notfallplan-startet-deutschland-gesundheit-arzt-aerzte-aerztinnen-mangel-personalmangel-zu-zr-92637803.html https://www.aerztezeitung.de/Wirtschaft/Wenn-die-VERAH-im-Gemeinderaum-wartet-443584.html https://www.aerztezeitung.de/Politik/Practica-Heftige-Kontroverse-um-Bedeutung-von-KVen-444133.html https://t3n.de/news/telemedizin-haustiere-amazon-1584465/ Wir machen Pause bis zum 9. Januar 2024. Tanken wieder auf.Dann wird es im Januar noch zwei Folgen „Charité Special“ geben, in denen wir uns mehr mit dem digitalen und smarten Krankenhaus beschäftigen. Wir haben Prof. Hayo Krömer im Interview, Dr. Peter Gocke und Achim de Greiff vom UK Essen.Im Februar starten wir dann durch, mit unserem Themenmonat „Longevity – Do you really want to live forever?” Dazu waren trafen uns mit WissenschaftlerInnen, die sich mit der Unsterblichkeit beschäftigen, mit Company Buildern, die das große Potential dieses Marktes sehen, mit Propheten und Skeptikern und ich habe begonnen, mich einem Selbstversuch zu unterziehen.Schreibt uns Eure Kommentare gerne an MehrEinsatzWagen@healthcarefuturists.com und vernetzt euch mit uns auf unseren Social Media Kanälen.
Let's do a neurologic case featuring an American music legend who sought help after developing unusual headaches and a distorted sense of smell. We'll figure out what happened and who it is in this installment! Avoid clicking through the references if you wish to keep the mystery intact. Referenceshttps://www.thelancet.com/action/showPdf?pii=S0140-6736%2817%2931623-9 Lancet Letter Wikipedia Page for the mystery patient.https://link.springer.com/article/10.1007/s00415-011-6034-9 Duret biography, Journal of Neurologyhttps://stanfordmedicine25.stanford.edu/blog/archive/2014/The-Babinski-Sign.html The Babinski Sign summary, Stanford Med Support the showSponsor: Artery InkUse promo code HISTORYPOD at Artery Ink's website to save 10%* on your order of $35 or more and show support for our show as well as for a homegrown, wonderful local company. Artery Ink specializes in apparel and decor inspired by anatomy and the human body. Whether you're in the field of healthcare or not, Artery Ink has something that will definitely appeal to you so go and check them out! (*Discount code does not apply to subscription boxes)Submissions for Mike's Trivia Challenge Segment:-We invite our audience to submit medical history trivia questions (with or without a supporting article) to see if Mike happens to know the answer off the top of his head.-If Mike is wrong we'll award you your very own medical eponym so that you can join us in becoming a part of medical history.-Submit through our website, social media DMs, or via e-mail: poorhistorianspod@gmail.comPodcast Links:-Linktree (reviews/ratings/social media links): linktr.ee/poorhistorianspod
In de podcastserie Proefschriften spreekt aios Interne geneeskunde dr. Tessa Steenbruggen met promovendi. In deze aflevering spreekt zij met longarts Daphne Dumoulin over haar proefschrift, getiteld “Becoming the apex predator | Improving immunotherapeutic strategies in patients with thoracic malignancies”. Aan bod komen onder andere waarom zij onderzoek ging doen, de belangrijkste resultaten, en haar verwachtingen voor de behandeling van kleincellig longcarcinoom en mesothelioom. Daphne zal op 26 januari 2024 haar proefschrift verdedigen aan de Erasmus Universiteit.Referenties SCLC review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264327/pdf/tlcr-10-06-2970.pdf SCLC cohort: https://www.ejcancer.com/action/showPdf?pii=S0959-8049%2823%2900337-4 Muisstudie dendritische cel therapie: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092125/pdf/IJC-152-1438.pdf Algoritme nierinsufficiëntie: https://www.jto.org/action/showPdf?pii=S1556-0864%2820%2930336-1
Find Monica: Website: https://monicasdeepdives.com Twitter: https://twitter.com/monicaperezshow Rokfin: https://rokfin.com/deepdives Rumble: https://rumble.com/user/monicaperezshow YouTube: https://www.youtube.com/c/MonicaPerez Shownotes: 1) EMA Quality Report - Rapporteurs-Rolling-Review-Report-Quality-COVID-19-mRNA-Vaccine- BioNTec.doc (live.com) 2) SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination: https://onlinelibrary.wiley.com/doi/10.1111/apm.13294 3) Biodistribution of mRNA COVID-19 vaccines in human breast milk https://www.thelancet.com/action/showPdf?pii=S2352-3964%2823%2900366-3 4) FDA - Emergency Use Authorization (EUA) for an Unapproved Product Review Memorandum https://www.fda.gov/media/144416/download 5) EMA Comirnaty Assessment Report - https://www.ema.europa.eu/en/documents/assessment- report/comirnaty-epar-public-assessment-report_en.pdf 6) Three decades of messenger RNA vaccine development - ScienceDirect 7) Frontiers | Are There Hidden Genes in DNA/RNA Vaccines? (frontiersin.org) 8) Effect of mRNA Vaccine Manufacturing Processes on Efficacy and Safety Still an Open Question | The BMJ 9) Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line (nih.gov) 10) dsDNA variance in Pfizer Docs - by Anandamide (substack.com) 11) COVID-19 primary series and booster vaccination and immune imprinting https://www.medrxiv.org/content/10.1101/2022.10.31.22281756v1.full.pdf 12) Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025 13) A SYSTEMATIC REVIEW OF AUTOPSY FINDINGS IN DEATHS AFTER COVID-19 VACCINATION: https://zenodo.org/record/8120771 14) Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine (Cleveland Clinic Study): https://academic.oup.com/ofid/article/10/6/ofad209/7131292?login=false 15) Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents: https://pubmed.ncbi.nlm.nih.gov/36006288/ 16) Deep sequencing of the Moderna and Pfizer bivalent vaccines identifies contamination of expression vectors designed for plasmid amplification in bacteria | Kevin McKernan: https://rumble.com/v2c785k-march-8-2023.html?mref=umbzp&mc=dprv6 17) BNT162b2 Vaccine-Associated Myo/Pericarditis in Adolescents: A Stratified Risk-Benefit Analysis: https://onlinelibrary.wiley.com/doi/10.1111/eci.13759 18) SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents: https://jamanetwork.com/journals/jamacardiology/fullarticle/2791253 19) Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults: https://www.sciencedirect.com/science/article/pii/S0264410X22010283 20) N1 methylpseudouridine is incorporated with higher fdelity than pseudouridine in synthetic RNAs (demonstrates high error rates) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335462/pdf/41598_2022_Article_17249.pdf 22) LNP packaging of dsDNA: https://anandamide.substack.com/p/lnp-packaging-of-dsdna 23) IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222767/ 24) COVID-19 vaccine-associated mortality in the Southern Hemisphere: https://correlation- canada.org/covid-19-vaccine-associated-mortality-in-the-southern-hemisphere/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Find Monica: Website: https://monicasdeepdives.com Twitter: https://twitter.com/monicaperezshow Rokfin: https://rokfin.com/deepdives Rumble: https://rumble.com/user/monicaperezshow YouTube: https://www.youtube.com/c/MonicaPerez Shownotes: 1) EMA Quality Report - Rapporteurs-Rolling-Review-Report-Quality-COVID-19-mRNA-Vaccine- BioNTec.doc (live.com) 2) SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination: https://onlinelibrary.wiley.com/doi/10.1111/apm.13294 3) Biodistribution of mRNA COVID-19 vaccines in human breast milk https://www.thelancet.com/action/showPdf?pii=S2352-3964%2823%2900366-3 4) FDA - Emergency Use Authorization (EUA) for an Unapproved Product Review Memorandum https://www.fda.gov/media/144416/download 5) EMA Comirnaty Assessment Report - https://www.ema.europa.eu/en/documents/assessment- report/comirnaty-epar-public-assessment-report_en.pdf 6) Three decades of messenger RNA vaccine development - ScienceDirect 7) Frontiers | Are There Hidden Genes in DNA/RNA Vaccines? (frontiersin.org) 8) Effect of mRNA Vaccine Manufacturing Processes on Efficacy and Safety Still an Open Question | The BMJ 9) Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line (nih.gov) 10) dsDNA variance in Pfizer Docs - by Anandamide (substack.com) 11) COVID-19 primary series and booster vaccination and immune imprinting https://www.medrxiv.org/content/10.1101/2022.10.31.22281756v1.full.pdf 12) Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025 13) A SYSTEMATIC REVIEW OF AUTOPSY FINDINGS IN DEATHS AFTER COVID-19 VACCINATION: https://zenodo.org/record/8120771 14) Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine (Cleveland Clinic Study): https://academic.oup.com/ofid/article/10/6/ofad209/7131292?login=false 15) Cardiovascular Manifestation of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents: https://pubmed.ncbi.nlm.nih.gov/36006288/ 16) Deep sequencing of the Moderna and Pfizer bivalent vaccines identifies contamination of expression vectors designed for plasmid amplification in bacteria | Kevin McKernan: https://rumble.com/v2c785k-march-8-2023.html?mref=umbzp&mc=dprv6 17) BNT162b2 Vaccine-Associated Myo/Pericarditis in Adolescents: A Stratified Risk-Benefit Analysis: https://onlinelibrary.wiley.com/doi/10.1111/eci.13759 18) SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents: https://jamanetwork.com/journals/jamacardiology/fullarticle/2791253 19) Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults: https://www.sciencedirect.com/science/article/pii/S0264410X22010283 20) N1 methylpseudouridine is incorporated with higher fdelity than pseudouridine in synthetic RNAs (demonstrates high error rates) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335462/pdf/41598_2022_Article_17249.pdf 22) LNP packaging of dsDNA: https://anandamide.substack.com/p/lnp-packaging-of-dsdna 23) IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222767/ 24) COVID-19 vaccine-associated mortality in the Southern Hemisphere: https://correlation- canada.org/covid-19-vaccine-associated-mortality-in-the-southern-hemisphere/ Learn more about your ad choices. Visit megaphone.fm/adchoices
In S4 E11 I am delighted to welcome Victoria Lister to the podcast. Victoria has an extensive background in hospitality, advertising and the non-profit sector. She is PhD researcher in the Department of Employment Relations and Human Resources and the Centre for Work, Organisation and Wellbeing at Griffith University. Her PhD research is in the area of employee voice and silence in healthcare. It examines what junior doctors do and don't speak up about at work and why, with a special interest in the professional forces that shape junior doctor silence. Victoria also researches the voice and silence experiences of early career academics; works on health workforce wellbeing initiatives; has a 'side hustle' as a designer and retailer of women's active and underwear; and will soon offer coaching as a path to voice for junior doctors who are MDs, PhDs. or both. In this conversation Victoria discusses her research work and defines employee voice and silence within the context of the healthcare environment. She describes the different lenses through which employee voice in healthcare can be viewed and expressed e.g patient safety and employee working conditions. We discuss in more detail her qualitative research with doctors and the junior doctor cohort in particular. Victoria explores the role of profession and culture and the so-called "hidden curriculum" of medicine and the barriers this can create to speaking up. Many core podcast themes and topics are re-visited in this, at times, hard to hear but crucial conversation. I am nevertheless encouraged by the hopeful pockets of excellence we highlight and the power of collective voice and momentum. Thank you Victoria.Links/references/resources:Victoria Lister victoria@victorialister.comvictorialister.comFollow me on LinkedInVictoria Lister |Hummingbird Pie | Underwear and Outerwear victoria@hummingbirdpie.com hummingbirdpie.com Healing the Professional Culture of Medicine article https://www.mayoclinicproceedings.org/action/showPdf?pii=S0025-6196%2819%2930345-3RACP Pomegranate Health Podcast episode https://podcasts.apple.com/au/podcast/ep101-setting-the-standard-for-workforce-wellbeing/id1022747864?i=1000629370015Gathering of Kindness events https://www.gatheringofkindness.org/gok-2023Beyond the Stethoscope Lucy Mayes https://www.lucymayes.com/beyond-the-stethoscopeOther sources of help and support: https://www.handnhand.org.auhttps://www.drs4drs.com.au The Mind Full Medic Podcast is proudly sponsored by the MBANSW Find out more about their service or donate today at www.mbansw.org.auDisclaimer: The content in this podcast is not intended to constitute or be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your doctor or other qualified health care professional. Moreover views expressed here are our own and do not necessarily reflect those of our employers or other official organisations.
หลังจากจบตอนที่ 1 ของหัวข้อนี้ น้องๆได้ความเข้าใจเรื่องความเกี่ยวพันระหว่างดัชนีมวลกายกับเบาหวานประเภทที่ 2 รับทราบว่าการได้รับพลังงานล้นเกิน ในคนที่มีระดับเพดานกักเก็บไขมันใต้ชั้นผิวหนังต่ำ (Personal Fat Threshold) อาจเป็นต้นกำเนิดของเบาหวานประเภทที่ 2 ในตอนจบนี้พี่ปุ๋มจะนำเอางานวิจัยที่สำคัญของ Prof.Roy Taylor ศาสตราจารย์ด้านอายุรศาสตร์และเมตาบอลิสม เป็น Director of Magnetic Resonance Center อยู่ที่ University of Newcastle สหราชอาณาจักร มาสรุปให้น้องๆฟังกัน เขาเป็นผู้ตั้งสมมุติฐานของ Personal Fat Threshold ว่าเป็นต้นกำเนิด (Aetiology) ของเบาหวานประเภทที่ 2 และสมมุติฐานของ Twin Cycle Hypothesis พี่ปุ๋มจะนำงานวิจัยที่สำคัญของ Prof.Roy Taylor มาสรุปให้น้องๆได้ฟังกันนะคะ โดยเฉพาะงานวิจัยฉบับล่าสุดที่เพิ่งตีพิมพ์สดๆร้อนๆซึ่งเป็นการทดสอบสมมุติฐาน Personal Fat Threshold ของเขาที่สำคัญ ลิงค์อ้างอิงงานวิจัย 7 ฉบับ Cause of Insulin Resistance: The Personal Fat Threshold (ตอนจบ) 1. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/pdf/125_2011_Article_2204.pdf 2. Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders https://diabetesjournals.org/care/article/39/5/808/30678/Very-Low-Calorie-Diet-and-6-Months-of-Weight 3. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://dacemirror.sci-hub.st/journal-article/54f864d9e758e0d7a4c02cc7d439d6c1/lean2017.pdf?download=true 4. Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery https://www.cell.com/action/showPdf?pii=S1550-4131%2818%2930446-7 5. Aetiology of Type 2 diabetes in people with a ‘normal' body mass index: testing the personal fat threshold hypothesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472166/pdf/cs-137-cs20230586.pdf 6. From chronic overnutrition to insulin resistance: The role of fat-storing capacity and inflammation https://zero.sci-hub.st/1544/b69228f84ca76b1cfc1cd1bb4159b906/lionetti2009.pdf?download=true 7. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause https://link.springer.com/content/pdf/10.1007/s00125-008-1116-7.pdf?pdf=button
A review of current literature around magic mushrooms for nicotine and alcohol dependency, end of life therapy, and more. Notes: Per Christopher Toney, a reminder that psilocybin dosing is based on dry weight of the whole mushrooms, for those curious about how dosing is calculated. How well does this approximate actual psilocybin content? This will be a good future topic for discussion. References: Link to FDA's Considerations for Clinical Investigations of Psychedelic Drugs (Accessed 11 July 2023): https://www.fda.gov/regulatory-information/search-fda-guidance-documents/psychedelic-drugs-considerations-clinical-investigations. Bogenschutz MP, et al. Percentage of heavy drinking days following psilocybin assisted psychotherapy vs placebo in the treatment of patients with alcohol use disorder: a randomized clinical trial. JAMA Psychiatry. 2022; 79(10): 953-962 https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2795625 Carhart-Harris R, et al. Trial of psilocybin versus escitalopram for depression. New England Journal of Medicine. 2021: 384: 1402-1411. https://www.nejm.org/doi/full/10.1056/nejmoa2032994 Ebbesen-Jensen M, et al. Psilocybin assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomized, double blinded, placebo controlled 12 week clinical trial (the QUANTUM trip trial). BMJ Open. 2022; 12(10). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577917/ Ercolano, A. (2023) Johns Hopkins Center for psychedelic and Consciousness Research, Johns Hopkins Medicine. Available at: https://www.hopkinsmedicine.org/psychiatry/research/psychedelics-research.html Fauber J and Fiore K. Slippery slope: Fen-Phen users recall a “miracle” turned nightmare. Milwaukee Journal Sentinel/Med Page Today. 19 April 2015. https://www.medpagetoday.com/special-reports/slipperyslope/51044 Goodwin GM, et al. Single dose psilocybin for treatment for a treatment resistant episode of major depression. New England Journal of Medicine. 2022; 387(18). https://www.nejm.org/doi/pdf/10.1056/NEJMoa2206443?articleTools=true Griffiths RR, et al. Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double blind trial. Journal of Psychopharmacology. 2016; 30(2): 1181-1197 Grob CS, et al. Pilot study of psilocybin for anxiety in patients with advanced stage cancer. JAMA Psychiatry. 2011; 68(1): 71-78. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/210962 Kenney A. What to know about Colorado's psychedelic law. Colorado Public Radio. 21 June 2023. https://www.cpr.org/2023/06/21/colorado-psychedelic-law-for-psilocybin-mushrooms/ Rosenbaum D, et al. Psychedelics for existential distress in palliative and cancer care. Current Oncology. 2019; 26(4): 225-226. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726261/ Ross S, et al. Acute and sustained reductions in loss of meaning and suicidal ideation following psilocybin-assisted psychotherapy for psychiatric and existential distress in life threatening cancer. ACS Pharmacology and Translational Science. 2021; 4(2): 553-562. https://pubmed.ncbi.nlm.nih.gov/33860185/ Rotz VR, et al. Single dose psilocybin assisted therapy in major depressive disorder: a placebo controlled, randomized double blind trial. The Lancet. 2023;56: 101809. https://www.thelancet.com/action/showPdf?pii=S2589-5370%2822%2900538-7 To read about “Mad Honey” that we referenced towards the end of the podcast: see here: https://bigthink.com/health/mad-honey/#:~:text=But%20what%20really%20distinguishes%20mad,%2C%20in%20rare%20cases%2C%20death.
#164 Something some common and useful in our everyday lives, from gloves to toy balls, what even is rubber? What makes it rubber, and what makes it different and unique from other substances? Also, where does it come from? Let's find out.References from this episode https://www.chemistryworld.com/podcasts/rubber/3005929.article https://www.scientificamerican.com/article/stretch-it-how-does-temperature-affect-a-rubber-band/ https://youtu.be/n2zOdsxC_eo https://youtu.be/54-rMC_67TM https://youtu.be/qnAhsioaHug https://www.fs.usda.gov/wildflowers/ethnobotany/latex.shtml https://www.jacionline.org/action/showPdf?pii=S0091-6749%2802%2900098-2 Thanks to our monthly supporters Suzanne Phillips Nelly Silva Venus Rebholz Lyn Stubblefield Jacob Taber Brian Kimball shadow Emerson Woodhall Nichole Criss Kristina Gotfredsen Timothy Parker Steven Boyles Chris Skupien Chelsea B Bri McAllister Avishai Barnoy Hunter Reardon ★ Support this podcast on Patreon ★ Check out our website at chemforyourlife.comWatch our episodes on YouTubeFind us on Instagram, Twitter, and Facebook @ChemForYourLife.Want to start your own podcast? Use Transistor and you'll have the best podcast platform available. We use it and we are totally in love with it.
In this week's episode, your hosts dive deep into all things low stomach acid. Many people struggle with GI symptoms such as acid reflux, heartburn, bloating, and more. While the majority of the population is often told they have too much stomach acid and are then prescribed an acid-blocking medication, Kara and Kylie are here to help you understand why that actually may not be the case or best route. Your hosts dive into common misconceptions around stomach acid, its important roles in your body, the GI issues we can see if we don't have enough stomach acid, and also, how to improve stomach acid levels / optimize overall digestive capacity. If you've been struggling with these chronic GI issues, this episode is for you! Follow the NYQF Podcast Instagram: https://www.instagram.com/notyourquickfixpodcast/ Connect with Kara: Instagram: Instagram.com/karagoss_rd Facebook: https://www.facebook.com/groups/523529175060599 TikTok: https://www.tiktok.com/@karagoss_rd Connect with Kylie: Instagram: Instagram.com/writewithkylie TikTok: https://www.tiktok.com/@heyitskylie_13 Studies and Articles Referenced: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429051/#:~:text=Peptic%20ulcer%20disease%20treatment%20guidelines,who%20have%20GI%20risk%20factors (PMID: 28500192) https://www.mayoclinicproceedings.org/action/showPdf?pii=S0025-6196%2817%2930841-8 (PMID: 29406201) https://chriskresser.com/what-everybody-ought-to-know-but-doesnt-about-heartburn-gerd/?fbclid=IwAR1KfoDx2-6BJP8cz6eoZOVp-f23SjFmCJ5KUOS31FVc-VTQbeAheHp_Tpc https://chriskresser.com/the-hidden-causes-of-heartburn-and-gerd/
The UN population report says India is set to surpass China in population, but why is Beijing brooding (and being borderline racist) over this instead of celebrating? In Ep 1217 of Cut The Clutter, Editor-in-Chief Shekhar Gupta explains key takeaways from the UN report, and the demographic shifts India & the world are likely to see. @sarvodayahealthcare4702 ----more----Read UN population report here: https://www.unfpa.org/sites/default/files/swop23/SWOP2023-ENGLISH-230329-web.pdf----more----Watch cut the Clutter episode 534 here: https://youtu.be/V-o7f5_aEqs----more----Read Lancet's study here: https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2930677-2
We'll look inward this week to talk about the history of our own specialty as emergency physicians. People may not be aware that the practice of emergency medicine is relatively new in the house of medicine. Before the 1970's the ER was a very different place as you'll find out. Link to documentary called 24/7/365 on the topic discussed in episode (courtesy of EMRA - the Emergency Medicine Residents' Association): https://www.emra.org/about-emra/publications/legacy-documentary/#247365documentarySources:https://www.annemergmed.com/action/showPdf?pii=S0196-0644%2804%2901836-0https://www.acep.org/static/globalassets/resources/content/horizontal-timeline/index.htmlhttps://www.history.com/news/americans-once-avoided-the-hospital-at-all-costs-until-ers-changed-thathttps://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1056&context=ymtdlSponsor: Artery InkUse promo code PHPOD at Artery Ink's website to save 10%* on your order of $35 or more and show support for our show as well as for a homegrown, wonderful local company. Artery Ink specializes in apparel and decor inspired by anatomy and the human body. Whether you're in the field of healthcare or not, Artery Ink has something that will definitely appeal to you so go and check them out! (*Discount code does not apply to subscription boxes)Submissions for Mike's Mailbag Segment:-We invite our audience to submit medical history trivia questions (with or without a supporting article) to see if Mike happens to know the answer off the top of his head.-If Mike is wrong we'll award you your very own medical eponym so that you can join us in becoming a part of medical history.-Submit through our website or via e-mail: poorhistorianspod@gmail.comPodcast Links:-Linktree (reviews/ratings/social media links): linktr.ee/poorhistorianspod-Merch Site: https://www.teepublic.com/user/poor-historians-podcast
To tell or not to tell. When it comes to disclosing your MS to friends and family, that is the question. Choosing when to disclose and to whom to disclose is a deeply personal decision. Joining me to talk about some of the risks and benefits of disclosing your diagnosis is Dr. Victoria Leavitt, a clinical neuropsychologist, researcher, and assistant professor of neuropsychology at Columbia University. Well also tell you about a just-announced collaboration to develop an Epstein-Barr Virus vaccine (and we'll tell you why that could be a huge step toward ending MS forever!) We're sharing the details behind the MS International Federation's application to have three MS disease-modifying therapies added to the World Health Organization's list of essential medicines. We'll tell you how a study that tested a fall prevention program for people living with MS who used a wheelchair or scooter full-time may have failed...and yet succeeded. We're sharing the results of a study that set out to determine whether people over 50 who were living with MS were increasing their use of health care services because of their MS or simply because they were aging. And we'll tell you about a study that focused on the psychosocial impact of MS on children who had a parent living with MS. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: Disclosing Your MS :22 Merck teams up with ModeX Therapeutics on an EBV vaccine 1:10 The MSIF applies to have 3 DMTs added to the WHO list of essential medicines 3:22 STUDY: A fall prevention program for people with MS who are full-time wheelchair or scooter users 6:47 STUDY: Health care usage among people over 50 who are living with MS 9:33 STUDY: The psychosocial impact of MS on children with a parent living with MS 12:02 Dr. Victoria Leavitt discusses the risks and rewards associated with disclosing your MS to friends and family 15:24 Share this episode 32:35 Have you downloaded the free RealTalk MS app? 32:55 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/290 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com Editorial: Toward Equitable Access to Treatment for Multiple Sclerosis https://thelancet.com/action/showPdf?pii=S1474-4422%2823%2900041-8 STUDY: Online Delivery of the Individualized Reduction of Falls Intervention for Persons with Multiple Sclerosis Who Use a Wheelchair or Scooter Full-Time: A Pilot Study https://meridian.allenpress.com/ijmsc/article/25/2/82/491441/Online-Delivery-of-the-Individualized-Reduction-of STUDY: Outcomes and Health Care Service Use in Adults 50 Years and Older With and Without Multiple Sclerosis https://meridian.allenpress.com/ijmsc/article/25/2/56/486192/Outcomes-and-Health-Care-Service-Use-in-Adults-50 STUDY: The Psychosocial Impact of Parental Multiple Sclerosis on Children and Adolescents: A Systematic Review https://meridian.allenpress.com/ijmsc/article/25/2/63/487609/The-Psychosocial-Impact-of-Parental-Multiple Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 291 Guest: Dr. Victoria Leavitt Tags: MS, MultipleSclerosis, MSResearch, MSSociety, RealTalkMS Privacy Policy
We are diving deep into a new series today talking all about cholesterol. We demonize cholesterol in conventional medicine – and there are valid points to be concerned about elevated levels. There are also very valid reasons to not treat a “borderline” level. I had to throw that word in there. If you know me then you know that I hate that word – borderline. All that means is we are waiting for diagnosable disease. I would rather not get a full blown disease. Today we are going to discuss what cholesterol actually is. Why should we care about cholesterol. Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. ** Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/ ** Level up your products: https://www.ewg.org/ewgverified/ ** Find a certified Functional Medicine Practitioner: https://www.ifm.org/find-a-practitioner/ ** Interesting articles for more information** Physiological and pathological implications of cholesterol: https://www.imrpress.com/journal/FBL/19/3/10.2741/4216 Dietary Cholesterol and the Lack of Evidence in Cardiovascular Disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024687/ Serum Cholesterol Levels and Risk of Cardiovascular Death: A Systematic Review and a Dose-Response Meta-Analysis of Prospective Cohort Studies: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316578/ The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602982/ The Microbiome Revolution Turns to Cholesterol: https://www.cell.com/action/showPdf?pii=S1931-3128%2820%2930407-8 MITOCHONDRIAL CHOLESTEROL AND CANCER: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882000/ Impact of Cholesterol Metabolism in Immune Cell Function and Atherosclerosis”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400846/pdf/nutrients-12-02021.pdf Effects of dietary fats on blood lipids: a review of direct comparison trials: https://openheart.bmj.com/content/5/2/e000871 Cholesterol transport in steroid biosynthesis: Role of protein interactions and implications in disease states: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757135/pdf/nihms128256.pdf Cholesterol: Its Regulation and Role in Central Nervous System Disorders: https://www.hindawi.com/journals/cholesterol/2012/292598/ Cholesterol Metabolism in the Brain and Its Association with Parkinson's Disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844833/pdf/en-28-554.pdf Updated Understanding of the Crosstalk Between Glucose/Insulin and Cholesterol Metabolism: https://www.frontiersin.org/articles/10.3389/fcvm.2022.879355/full
ReferencesWe considered the effect of a high protein diet and potential metabolic acidosis on kidney function. This review is of interest by Donald Wesson, a champion for addressing this issue and limiting animal protein: Mechanisms of Metabolic Acidosis-Induced Kidney Injury in Chronic Kidney DiseaseHostetter explored the effect of a high protein diet in the remnant kidney model with 1 ¾ nephrectomy. Rats with reduced dietary acid load (by bicarbonate supplementation) had less tubular damage. Chronic effects of dietary protein in the rat with intact and reduced renal massWesson explored treatment of metabolic acidosis in humans with stage 3 CKD in this study. Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rateIn addition to the effect of metabolic acidosis from a diet high in animal protein, this diet also leads to hyperfiltration. This was demonstrated in normal subjects; ingesting a protein diet had a significantly higher creatinine clearance than a comparable group of normal subjects ingesting a vegetarian diet. Renal functional reserve in humans: Effect of protein intake on glomerular filtration rate.This finding has been implicated in Brenner's theory regarding hyperfiltration: The hyperfiltration theory: a paradigm shift in nephrologyOne of multiple publications from Dr. Nimrat Goraya whom Joel mentioned in the voice over: Dietary Protein as Kidney Protection: Quality or Quantity?We wondered about the time course in buffering a high protein meal (and its subsequent acid load on ventilation) and Amy found this report:Effect of Protein Intake on Ventilatory Drive | Anesthesiology | American Society of Anesthesiologists Roger mentioned that the need for acetate to balance the acid from amino acids in parenteral nutrition was identified in pediatrics perhaps because infants may have reduced ability to generate acid. Randomised controlled trial of acetate in preterm neonates receiving parenteral nutrition - PMCHe also recommended an excellent review on the complications of parenteral nutrition by Knochel https://www.kidney-international.org/action/showPdf?pii=S0085-2538%2815%2933384-6 which explained that when the infused amino acids disproportionately include cationic amino acids, metabolism led to H+ production. This is typically mitigated by preparing a solution that is balanced by acetate. Amy mentioned this study that explored the effect of protein intake on ventilation: Effect of Protein Intake on Ventilatory Drive | Anesthesiology | American Society of AnesthesiologistsAnna and Amy reminisced about a Skeleton Key Group Case from the renal fellow network Skeleton Key Group: Electrolyte Case #7JC wondered about isolated defects in the proximal tubule and an example is found here: Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalitiesAnna's Voiceover re: Gastric neobladder → metabolic alkalosis and yes, dysuria. The physiology of gastrocystoplasty: once a stomach, always a stomach but not as common as you might think Gastrocystoplasty: long-term complications in 22 patientsSjögren's syndrome has been associated with acquired distal RTA and in some cases, an absence of the H+ ATPase, presumably from autoantibodies to this transporter. Here's a case report: Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosisCan't get enough disequilibrium pH? Check this out- Spontaneous luminal disequilibrium pH in S3 proximal tubules. Role in ammonia and bicarbonate transport.Acetazolamide secretion was studied in this report Concentration-dependent tubular secretion of acetazolamide and its inhibition by salicylic acid in the isolated perfused rat kidney. | Drug Metabolism & DispositionIn this excellent review, David Goldfarb tackles the challenging case of a A Woman with Recurrent Calcium Phosphate Kidney Stones (spoiler alert, many of these patients have incomplete distal RTA and this problem is hard to treat). Molecular mechanisms of renal ammonia transport excellent review from David Winer and Lee Hamm. OutlineOutline: Chapter 11- Regulation of Acid-Base Balance- Introduction - Bicarb plus a proton in equilibrium with CO2 and water - Can be rearranged to HH - Importance of regulating pCO2 and HCO3 outside of this equation - Metabolism of carbs and fats results in the production of 15,000 mmol of CO2 per day - Metabolism of protein and other “substances” generates non-carbonic acids and bases - Mostly from sulfur containing methionine and cysteine - And cationic arginine and lysine - Hydrolysis of dietary phosphate that exists and H2PO4– - Source of base/alkali - Metabolism of an ionic amino acids - Glutamate and asparatate - Organic anions going through gluconeogenesis - Glutamate, Citrate and lactate - Net effect on a normal western diet 50-100 mEq of H+ per day - Homeostatic response to these acid-base loads has three stages: - Chemical buffering - Changes in ventilation - Changes in H+ excretion - Example of H2SO4 from oxidation of sulfur containing AA - Drop in bicarb will stimulate renal acid secretion - Nice table of normal cid-base values, arterial and venous- Great 6 bullet points of acid-base on page 328 - Kidneys must excrete 50-100 of non-carbonic acid daily - This occurs by H secretion, but mechanisms change by area of nephron - Not excreted as free H+ due to minimal urine pH being equivalent to 0.05 mmol/L - No H+ can be excreted until virtually all of th filtered bicarb is reabsorbed - Secreted H+ must bind buffers (phosphate, NH3, cr) - PH is main stimulus for H secretion, though K, aldo and volume can affect this.- Renal Hydrogen excretion - Critical to understand that loss of bicarb is like addition of hydrogen to the body - So all bicarb must be reabsorbed before dietary H load can be secreted - GFR of 125 and bicarb of 24 results in 4300 mEq of bicarb to be reabsorbed daily - Reabsorption of bicarb and secretion of H involve H secretion from tubular cells into the lumen. - Thee initial points need to be emphasized - Secreted H+ ion are generated from dissociation of H2O - Also creates OH ion - Which combine with CO2 to form HCO3 with the help of zinc containing intracellular carbonic anhydrase. - This is how the secretion of H+ which creates an OH ultimately produces HCO3 - Different mechanisms for proximal and distal acidification - NET ACID EXCRETION - Free H+ is negligible - So net H+ is TA + NH4 – HCO3 loss - Unusually equal to net H+ load, 50-100 mEq/day - Can bump up to 300 mEq/day if acid production is increased - Net acid excretion can go negative following a bicarb or citrate load - Proximal Acidification - Na-H antiporter (or exchanger) in luminal membrane - Basolateral membrane has a 3 HCO3 Na cotransporter - This is electrogenic with 3 anions going out and only one cation - The Na-H antiporter also works in the thick ascending limb of LOH - How about this, there is also a H-ATPase just like found in the intercalated cells in the proximal tubule and is responsible for about a third of H secretion - And similarly there is also. HCO3 Cl exchanger (pendrin-like) in the proximal tubule - Footnote says the Na- 3HCO3 cotransporter (which moves sodium against chemical gradient NS uses negative charge inside cell to power it) is important for sensing acid-base changes in the cell. - Distal acidification - Occurs in intercalated cells of of cortical and medullary collecting tubule - Three main characteristics - H secretion via active secretory pumps in the luminal membrane - Both H-ATPase and H-K ATPase - H- K ATPase is an exchange pump, k reabsorption - H-K exchange may be more important in hypokalemia rather than in acid-base balance - Whole paragraph on how a Na-H exchanger couldn't work because the gradient that H has to be pumped up is too big. - H-ATPase work like vasopressin with premise H-ATPase sitting on endocarditis vesicles a=which are then inserted into the membrane. Alkalosis causes them to be recycled out of the membrane. - H secretory cells do not transport Na since they have few luminal Na channels, but are assisted by the lumen negative tubule from eNaC. - Minimizes back diffusion of H+ and promotes bicarb resorption - Bicarbonate leaves the cell through HCO3-Cl exchanger which uses the low intracellular Cl concentration to power this process. - Same molecule is found on RBC where it is called band 3 protein - Figure 11-5 is interesting - Bicarbonate resorption - 90% in the first 1-22 mm of the proximal tubule (how long is the proximal tubule?) - Lots of Na-H exchangers and I handed permeability to HCO3 (permeability where?) - Last 10% happens distally mostly TAL LOH via Na-H exchange - And the last little bit int he outer medullary collecting duct. - Carbonic anhydrase and disequilibrium pH - CA plays central role in HCO3 reabsorption - After H is secreted in the proximal tubule it combines with HCO# to form carbonic acid. CA then dehydrates it to CO2 and H2O. (Step 2) - Constantly moving carbonic acid to CO2 and H2O keeps hydrogen combining with HCO3 since the product is rapidly consumed. - This can be demonstrated by the minimal fall in luminal pH - That is important so there is not a luminal gradient for H to overcome in the Na-H exchanger (this is why we need a H-ATPase later) - CA inhibitors that are limited tot he extracellular compartment can impair HCO3 reabsorption by 80%. - CA is found in S1, S2 but not S3 segment. See consequence in figure 11-6. - The disequilibrium comes from areas where there is no CA, the HH formula falls down because one of the assumptions of that formula is that H2CO3 (carbonic acid) is a transient actor, but without CA it is not and can accumulate, so the pKa is not 6.1. - Bicarbonate secretion - Type B intercalated cells - H-ATPase polarity reversed - HCO3 Cl exchanger faces the apical rather than basolateral membrane- Titratable acidity - Weak acids are filtered at the glom and act as buffers in the urine. - HPO4 has PKA of 6.8 making it ideal - Creatinine (pKa 4.97) and uric acid (pKa 5.75) also contribute - Under normal cinditions TA buffers 10-40 mEa of H per day - Does an example of HPO4(2-):H2PO4 (1-) which exists 4:1 at pH of 7.4 (glomerular filtrate) - So for 50 mEq of Phos 40 is HPO4 and 10 is H2PO4 - When pH drops to 6.8 then the ratio is 1:1 so for 50 - So the 50 mEq is 25 and 25, so this buffered an additional 15 mEq of H while the free H+ concentration increased from 40 to 160 nanomol/L so over 99.99% of secreted H was buffered - When pH drops to 4.8 ratio is 1:100 so almost all 50 mEq of phos is H2PO4 and 39.5 mEq of H are buffered. - Acid loading decreases phosphate reabsorption so more is there to act as TA. - Decreases activity of Na-phosphate cotransporter - DKA provides a novel weak acid/buffer beta-hydroxybutyrate (pKa 4.8) which buffers significant amount of acid (50 mEq/d).- Ammonium Excretion - Ability to excrete H+ as ammonium ions adds an important amount of flexibility to renal acid-base regulation - NH3 and NH4 production and excretion can be varied according to physiologic need. - Starts with NH3 production in tubular cells - NH3, since it is neutral then diffuses into the tubule where it is acidified by the low pH to NH4+ - NH4+ is ionized and cannot cross back into the tubule cells(it is trapped in the tubular fluid) - This is important for it acting as an important buffer eve though the pKa is 9.0 - At pH of 6.0 the ratio of NH3 to NH4 is 1:1000 - As the neutral NH3 is converted to NH4 more NH3 from theintracellular compartment flows into the tubular fluid replacing the lost NH3. Rinse wash repeat. - This is an over simplification and that there are threemajor steps - NH4 is produced in early proximal tubular cells - Luminal NH4 is partially reabsorbed in the TAL and theNH3 is then recycled within the renal medulla - The medullary interstitial NH3 reaches highconcentrations that allow NH3 to diffuse into the tubular lumen in the medullary collecting tubule where it is trapped as NH4 by secreted H+ - NH4 production from Glutamine which converts to NH4 and glutamate - Glutamate is converted to alpha-ketoglutarate - Alpha ketoglutarate is converted to 2 HCO3 ions - HCO3 sent to systemic circulation by Na-3 HCO3 transporter - NH4 then secreted via Na-H exchanger into the lumen - NH4 is then reabsorbed by NaK2Cl transporter in TAL - NH4 substitutes for K - Once reabsorbed the higher intracellular pH causes NH4 to convert to NH3 and the H that is removed is secreted through Na-H exchanger to scavenge the last of the filtered bicarb. - NH3 diffuses out of the tubular cells into the interstitium - NH4 reabsorption in the TAL is suppressed by hyperkalemia and stimulated by chronic metabolic acidosis - NH4 recycling promotes acid clearance - The collecting tubule has a very low NH3 concentration - This promotes diffusion of NH3 into the collecting duct - NH3 that goes there is rapidly converted to NH4 allowing more NH3 to diffuse in. - Response to changes in pH - Increased ammonium excretion with two processes - Increased proximal NH4 production - This is delayed 24 hours to 2-3 days depending on which enzyme you look at - Decreased urine pH increases diffusion of ammonia into the MCD - Occurs with in hours of an acid load - Peak ammonium excretion takes 5-6 days! (Fig 11-10) - Glutamine is picked up from tubular fluid but with acidosis get Na dependent peritublar capillary glutamine scavenging too - Glutamine metabolism is pH dependent with increase with academia and decrease with alkalemia - NH4 excretion can go from 30-40 mEq/day to > 300 with severe metabolic acidosis (38 NaBicarb tabs) - Says each NH4 produces equimolar generation of HCO3 but I thought it was two bicarb for every alpha ketoglutarate?- The importance of urine pH - Though the total amount of hydrogren cleared by urine pH is insignificant, an acidic urine pH is essential for driving the reactions of TA and NH4 forward.- Regulation of renal hydrogen excretion - Net acid excretion vary inverse with extracellular pH - Academia triggers proximal and distal acidification - Proximally this: - Increased Na-H exchange - Increased luminal H-ATPase activity - Increased Na:3HCO3 cotransporter on the basolateral membrane - Increased NH4 production from glutamine - In the collecting tubules - Increased H-ATPase - Reduction of tubular pH promotes diffusion of NH3 which gets converted to NH4…ION TRAPPING - Extracellular pH affects net acid excretion through its affect on intracellular pH - This happens directly with respiratory disorders due to movement of CO2 through the lipid bilayer - In metabolic disorders a low extracellular bicarb with cause bicarb to diffuse out of the cell passively, this lowers intracellular pH - If you manipulate both low pCO2 and low Bicarb to keep pH stable there will be no change in the intracellular pH and there is no change in renal handling of acid. It is intracellular pH dependent - Metabolic acidosis - Ramps up net acid secretion - Starts within 24 hours and peaks after 5-6 days - Increase net secretion comes from NH4 - Phosphate is generally limited by diet - in DKA titratable acid can be ramped up - Metabolic alkalosis - Alkaline extracellular pH - Increased bicarb excretion - Decrease reabsorption - HCO3 secretion (pendrin) in cortical collecting tubule - Occurs in cortical intercalated cells able to insert H-ATPase in basolateral cells (rather than luminal membrane) - Normal subjects are able to secrete 1000 mmol/day of bicarb - Maintenance of metabolic alkalosis requires a defect which forces the renal resorption of bicarb - This can be chloride/volume deficiency - Hypokalemia - Hyperaldosteronism - Respiratory acidosis and alkalosis - PCO2 via its effect on intracellular pH is an important determinant of renal acid handling - Ratios he uses: - 3.5 per 10 for respiratory acidosis - 5 per 10 for respiratory alkalosis - Interesting paragraph contrasting the response to chronic metabolic acidosis vs chronic respiratory acidosis - Less urinary ammonium in respiratory acidosis - Major differences in proximal tubule cell pH - In metabolic acidosis there is decreased bicarb load so less to be reabsorbed proximally - In respiratory acidosis the increased serum bicarb increases the amount of bicarb that must be reabsorbed proximally - The increased activity of Na-H antiporter returns tubular cell pH to normal and prevents it from creating increased urinary ammonium - Mentions that weirdly more mRNA for H-Na antiporter in metabolic acidosis than in respiratory acidosis - Net hydrogen excretion varies with effective circulating volume - Starts with bicarb infusions - Normally Tm at 26 - But if you volume deplete the patient with diuretics first this increases to 35+ - Four factors explain this increased Tm for bicarb with volume deficiency - Reduced GFR - Activation of RAAS - Ang2 stim H-Na antiporter proximally - Ang2 also stimulates Na-3HCO3 cotransporter on basolateral membrane - Aldosterone stimulates H-ATPase in distal nephron - ALdo stimulates Cl HCO3 exchanger on basolateral membrane - Aldo stimulates eNaC producing tubular lumen negative charge to allow H secretion to occur and prevents back diffusion - Hypochloremia - Increases H secretion by both Na-dependent and Na-independent methods - If Na is 140 and Cl is 115, only 115 of Na can be reabsorbed as NaCl, the remainder must be reabsorbed with HCO3 or associated with secretion of K or H to maintained electro neutrality - This is enhanced with hypochloridemia - Concurrent hypokalemia - Changes in K lead to trans cellular shifts that affect inctracellular pH - Hypokalemia causes K out, H in and in the tubular cell the cell acts if there is systemic acidosis and increases H secretion (and bicarbonate resorption) - PTH - Decreases proximal HCO3 resorption - Primary HyperCard as cause of type 2 RTA - Does acidosis stim PTH or does PTH stim net acid excretion
As the world has been distracted by the Chinese Balloon Show, Dr. Fauci and Not-a-Dr. Billy Gates have been quietly backpedaling on their "safe-and-effective" propaganda for these gene-editing injections. We cover a few important things in the news you may have missed these past few weeks. Here are some references you may find useful after listening to today's episode: Bill Gates backpedaling: https://gab.com/abnd/posts/109819689391888349 Fauci covering his tracks: https://www.cell.com/action/showPdf?pii=S1931-3128%2822%2900572-8 Dr. Geert Vanden Bossche website: https://www.voiceforscienceandsolidarity.org/ Scott Adams Concedes Victory to “Anti-vaxxers”: https://youtu.be/C41GCgyG4mI Utah Plastic Surgeon Sold Fake Vaccine Cards: https://www.ksl.com/article/50560529/utah-plastic-surgeon-sold-covid-19-vax-cards-but-threw-away-the-vaccine-feds-say -- As always, views expressed here are our own or those of our guests. This show should not be taken as medical advice. Please consult with your personal physicians regarding anything we say. -- Connect with our office online at https://downtowngilberthealthcare.com or on Facebook at https://facebook.com/downtowngilberthealthcare Follow Dr. Dan on TikTok: @doctordantheman Find Dr. Bradford on Gab: @abnd or Instagram: @dralanbradford --- Send in a voice message: https://anchor.fm/communityguidelines/message Support this podcast: https://anchor.fm/communityguidelines/support
On this week's podcast, Drs.Feigenbaum and Baraki review the management of obesity. Sponsors: https://generalleathercraft.com/ References: Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2022-060640/190443/Clinical-Practice-Guideline-for-the-Evaluation-and?autologincheck=redirected Clinical Practice Guidelines For Healthy Eating For Prevention and Treatment of Metabolic and Endocrine Diseases in Adults by AACE https://www.endocrinepractice.org/action/showPdf?pii=S1530-891X%2820%2943460-3 2022 American Society for Metabolic and Bariatric Surgery and International Federation for the Surgery of Obesity and Metabolic Disorders: Indications for Metabolic and Bariatric Surgery https://www.soard.org/article/S1550-7289(22)00641-4/fulltext The importance of gene–environment interactions in human obesity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381863/ Four-Year Weight Losses in the Look AHEAD Study: Factors Associated with Long-Term Success https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183129/ Orlistat Augments Postprandial Increases in Glucagon-like Peptide 1 in Obese Type 2 Diabetic Patients https://pubmed.ncbi.nlm.nih.gov/15111524/ GLP-1 physiology informs the pharmacotherapy of obesity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859548/ The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613929/ Seminars https://www.barbellmedicine.com/seminars/ For more of our stuff: App: https://tinyurl.com/muus5pfn Podcasts: goo.gl/X4H4z8 Website: www.barbellmedicine.com Instagram: @austin_barbellmedicine @jordan_barbellmedicine @leah_barbellmedicine @vanessa_barbellmedicine @untamedstrength @derek_barbellmedicine @hassan_barbellmedicine @charlie_barbellmedicine @alex_barbellmedicine @tomcampitelli @joe_barbellmedicine @rheece_barbellmedicine @cam_barbellmedicine @claire_barbellmedicine @ben_barbellmedicine @cassi.niemann @caleb_barbellmedicine Email: info@barbellmedicine.com Supplements/Templates/Seminars: www.barbellmedicine.com/shop/ Forum: forum.barbellmedicine.com/
Featured Guest: Patrick Prioletti, Founder, Psily About the Guest: I'm a former ML engineer, cybersecurity/privacy researcher and energy policy researcher turned app builder. My goal is to increase access to novel health and therapeutic tools and build products that can make a real impact in someone's life while improving humanities collective understanding of new health paradigms.
Henry Kandel, my former professor who is currently working on integrating yoga practices into hallucinogenic states used for healing, joins the Rainy Night Radio to discuss altered states of reality. This podcast discusses the similarities between lucid dreaming and drug induced mindstates, and their link to mental health and spiritual practice. We cover a broad range of topics ranging from drug prohibition, lucid dreaming as a form of practice, and the benefits and lucid dreaming and drug induced mind states, to what altered states of reality say about the concept of reality itself.Article with statistics referenced in podcast on people surveyed after experiences with “bad trips” on psilocybin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551678/pdf/nihms884924.pdf“The Tibetan Yogas of Dream and Sleep”https://selfdefinition.org/tibetan/Tenzin-Wangyal-Rinpoche-The-Tibetan-Yogas-Of-Dream-And-Sleep.pdfOther articles on psilocybin in clinical trials:“Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12 month follow-up”https://journals.sagepub.com/doi/epub/10.1177/02698811211073759“Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: An open-label safety and feasibility pilot study”https://www.thelancet.com/action/showPdf?pii=S2589-5370%2820%2930282-0“Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer” https://journals.sagepub.com/doi/epub/10.1177/0269881119897615
Processed vs Unprocessed Foods Study: https://www.cell.com/action/showPdf?pii=S1550-4131%2819%2930248-7 If you'd like to join the free Coach Fitzz Facebook Group for workouts, recipes, form tips, and much more click: www.facebook.com/groups/fit40family/ Find me on… Website ► https://coachfitzz.com/ Email ► coachfitzz1@gmail.com Instagram ► https://www.instagram.com/coach_fitzz/?hl=en TikTok ► https://www.tiktok.com/@coach_fitzz?lang=en
Today we are going to dive deep into Hashimoto's autoimmune disease. What exactly is this condition? What are the risk factors for developing this autoimmune condition, are there specific causes for it? What are some signs and symptoms, what are the complications of this condition, and finally, we will talk about the management of Hashimoto's autoimmune disease. This is going to be a doozy of an episode today. This is a topic I am very passionate about – as I was diagnosed with this autoimmune disease at the beginning of this year. This is a topic we need to discuss, and it needs to be in the forefront of our brains as it is very common! Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. **Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/ ** Level up your products: https://www.ewg.org/ewgverified/ The Funktional Nutritionist: https://www.thefunktionalnutritionist.com/ Dr. Hyman: https://drhyman.com/ **Interesting articles for more information** Persisting symptoms in patients with Hashimoto's disease despite normal thyroid hormone levels: Does thyroid autoimmunity play a role? A systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122172/pdf/main.pdf Hashimoto Thyroiditis: https://www.ncbi.nlm.nih.gov/books/NBK459262/ Hashimoto's Disease: https://www.niddk.nih.gov/health-information/endocrine-diseases/hashimotos-disease The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) – 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial: https://www.europeanreview.org/wp/wp-content/uploads/051-059-Myo-inositol-and-selenium-restore-euthyroid-state.pdf Metformin Reverses Hashimoto's Thyroiditis by Regulating Key Immune Events: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193849/pdf/fcell-09-685522.pdf Microbiota and Thyroid Interaction in Health and Disease: https://www.cell.com/action/showPdf?pii=S1043-2760%2819%2930107-9 The effects of selenium supplementation on antibody titres in patients with Hashimoto's thyroiditis: https://journals.viamedica.pl/endokrynologia_polska/article/view/EP.a2021.0074/65249 An update on the pathogenesis of Hashimoto's thyroiditis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049926/ The importance of gluten exclusion in the management of Hashimoto's thyroiditis: https://www.aaem.pl/pdf-136523-71103?filename=The%20importance%20of%20gluten.pdf
How can hormone replacement therapy impact the health of a gender-diverse person? How do you know whether to use female or male reference values to calculate your caloric needs and other nutritional needs? Which nutritional principles would you benefit from basing your diet on as a gender-diverse or cisgender person? Dr. Whitney Linsenmeyer, a Registered Dietician, an Assistant Professor at Saint Louis University in Missouri, and a spokesperson for the Academy of Nutrition and Dietetics, joins me on the podcast to cover the answers to all these questions… and more! Resources: Dr. Whitney Linsenmeyer: https://www.slu.edu/doisy/faculty/linsenmeyer-whitney.php Dr. Linsenmeyer's gender-inclusive handouts on healthy eating guidelines: https://sites.google.com/slu.edu/transgendernutrition/home More information on the sex-specific aspect of a nutrition assessment – “An Examination of the Sex-Specific Nature of Nutrition Assessment within the Nutrition Care Process: Considerations for Nutrition and Dietetics Practitioners Working with Transgender and Gender Diverse Clients”: https://www.jandonline.org/action/showPdf?pii=S2212-2672%2822%2900106-X Harvard Health website for more information on the Mediterranean diet: https://www.health.harvard.edu WPATH Standards of Care: https://www.wpath.org/publications/soc University of California San Francisco Guidelines for the Primary and Gender-Affirming Care of Transgender and Gender Nonbinary People: https://transcare.ucsf.edu/guidelines The DASH diet: https://www.nhlbi.nih.gov/education/dash-eating-plan The Dietary Guidelines for Americans 2020-2025: https://www.dietaryguidelines.gov/sites/default/files/2020-12/Dietary_Guidelines_for_Americans_2020-2025.pdf The EatWell Guide (UK) - https://www.nhs.uk/live-well/eat-well/food-guidelines-and-food-labels/the-eatwell-guide/ Follow me on Instagram @nikias_fittotransform http://instagram.com/nikias_fittotransform/ Visit my website: https://www.fittotransformtraining.com Join the waiting list for Transformation Kickstart: https://www.fittotransformtraining.com/group-coaching.html Sign up for one on one coaching: https://www.fittotransformtraining.com/coaching.html Sign up for my free newsletter: https://mailchi.mp/157389602fb0/mailinglist Sign up for the No Quit Kit email series on fat loss success: https://mailchi.mp/4b368c26baa8/noquitkitsignup --- Send in a voice message: https://podcasters.spotify.com/pod/show/fit-to-transform/message
Ever worked with a client with PD who had low blood pressure? Maybe they showed up with BP that surprised you. Maybe they felt symptoms and maybe they didn't. Often their medical team has trouble managing their blood pressure because it can be affected by so many things and is a moving target. In today's show we share a case example as well as tangible steps and strategies for managing low BP in your clients with PD so they stop getting passed off from provider to provider to solve it. Top strategies from a talk by Horacio Kaufmann, MD from World Parkinson Congress 2016: Have your client drink 500 ml / 16.9 oz of water in the moment (add electrolytes if applicable) Put an abdominal binder low and tight on their abdomen Exercise: try boxing, upper extremity exercise with light weights or resistance bands, arm bike, recumbent bike Once stabilized be sure to work with the client in multiple positions to help their body accommodate (use clinical judgment based on your client when or if this is appropriate) PD meds articles from PFT meeting notes: https://www.mayoclinicproceedings.org/action/showPdf?pii=S0025-6196%2820%2930152-X https://www.mayoclinicproceedings.org/action/showPdf?pii=S0025-6196%2811%2965259-2 “Diagnosis and treatment of orthostatic hypotension” recent publication with Dr. Kaufmann https://pubmed.ncbi.nlm.nih.gov/35841911/ Abdominal binder option: https://www.amazon.com/dp/B005DLL0CS/ref=cm_sw_r_api_i_FWAV1V9Z6EE8SV2CPK5A_0
Long Story Short with Dr. Been Episode 15: Reduced Risk of Long COVID from Omicron As Compared to Delta Zoe app study printed in the Lancet demonstrates that in some cases the risk of long COVID in the Omicron era is 76% less than the long COVID in the Delta era. Let's review the data. DrBeen: Medical Education Online https://www.drbeen.com/ Home - FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ URL list from Friday, Jul. 1 2022 Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2 - The Lancet https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00941-2/fulltext#articleInformation Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2 https://www.thelancet.com/action/showPdf?pii=S0140-6736%2822%2900941-2 Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Have we ignored the mental health of healthcare workers? They help us but who is helping them? In this show we are talking about professionals that may need a new mental health focus and what that would look like. How can a current medical provider get help now? In this show I talk to Jennifer George. Jennifer is the author of her book Communication is Care, and also the host of the podcast the Healthcare Provider Happy Hour. I am always excited to speak to her since she covers this issue in her book and podcast. See Jennifer at http://jennifergeorge.co/ (Jennifergeorge.co) In this show we will address -What is the mental state of many healthcare workers? -Why do we care about the mental state of healthcare workers? -Is there a mental health stigma to getting help if you work in the healthcare field? -Do mental health issues get in the way of patient outcomes? -What improvements can be made in the system? -Can we learn from other professions facing similar issues? -Do healthcare providers suffer from trauma experiences? -Do healthcare workers get the help they need? -What elements could be in a future system to support healthcare professionals? Other thoughts from the show... A couple of corrections- 1) The definition of emotional exhaustion - it's when the investment outweighs the reward 2) Nurses are now included in the PTSD legislation in Ontario Canada (since 2017). Articles to reference - https://greatergood.berkeley.edu/article/item/why_are_so_many_female_doctors_burning_out (https://greatergood.berkeley.edu/article/item/why_are_so_many_female_doctors_burning_out) https://en.m.wikipedia.org/wiki/Suicide_among_doctors (https://en.m.wikipedia.org/wiki/Suicide_among_doctors) https://www.nytimes.com/2022/03/30/opinion/doctors-mental-health-stigma.html (https://www.nytimes.com/2022/03/30/opinion/doctors-mental-health-stigma.html) https://www.thelancet.com/action/showPdf?pii=S2589-5370%2821%2900370-9 (https://www.thelancet.com/action/showPdf?pii=S2589-5370%2821%2900370-9) https://www.nytimes.com/2022/03/30/opinion/doctors-mental-health-stigma.html (https://www.nytimes.com/2022/03/30/opinion/doctors-mental-health-stigma.html)
Drs Lidia Schapira and Antonio Wolff resume their discussion on the current research on DCIS and other forms of lower-risk early breast cancer, and how medical oncologists can work to create an optimal treatment plan. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/963167). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals. Resources Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2-, Node-Positive, High-Risk, Early Breast Cancer (monarchE) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768339/ Tamoxifen for early breast cancer: an overview of the randomised trials https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(97)11423-4/fulltext Adjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/AFT-05/BIG-14-03) https://ascopubs.org/doi/10.1200/JCO.21.02554?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Palbociclib for Residual High-Risk Invasive HR-Positive and HER2-Negative Early Breast Cancer—The Penelope-B Trial https://ascopubs.org/doi/10.1200/JCO.20.03639?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Verzenio® (abemaciclib) Significantly Reduced the Risk of Cancer Returning in People with High Risk HR+, HER2- Early Breast Cancer https://investor.lilly.com/news-releases/news-release-details/verzenior-abemaciclib-significantly-reduced-risk-cancer Pfizer Provides Update on Phase 3 PALLAS Trial of IBRANCE® (palbociclib) Plus Endocrine Therapy in HR+, HER2- Early Breast Cancer https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-phase-3-pallas-trial-ibrancer NATALEE: Phase III study of ribociclib (RIBO) + endocrine therapy (ET) as adjuvant treatment in hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) early breast cancer (EBC). https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.TPS597 FDA Approval Summary: Abemaciclib With Endocrine Therapy for High-Risk Early Breast Cancer https://ascopubs.org/doi/full/10.1200/JCO.21.02742#:~:text=The%20US%20Food%20and%20Drug,%2D67%20score%20%E2%89%A5%2020%25. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study https://www.annalsofoncology.org/action/showPdf?pii=S0923-7534%2821%2904494-X
We all will be at the receiving end of critical illness for ourselves or our loved ones. It is almost guaranteed. A family's needs are the blind spot of the overstretched and dysfunctional health care system that needs to be addressed. Here, Kristin Flanary, also known as Lady Glaucomflecken, shares her experience, hoping to highlight the challenges of the families who are at the revived end of critical illness for their loved one. Take-home lessons for health care professionals: While clinical excellence and focus on the patient is an absolute given, what sets a great HCP apart is clear and frequent communication, empathy and kindness. Let's do better. Intro :00 The interview :39 Tell me a bit about yourself. Where did you grow up? What was life like before and now? 3:40 Having to do CPR on your loved one 13:01 Can you share with me what exactly happened when your husband went into cardiac arrest? And what can we do better? 20:47 The experience of being in the hospital 28:42 How did you manage being kicked out of the hospital? How long was he in the ICU and in the hospital for? 47:25 The struggle starts for patients and families when they come home because now they don't have the same support system. Can you share some of those struggles? 55:10 We are almost 21 months out from the cardiac arrest at this point. How are you both doing now? 1:02:14 Spreading the message about sudden cardiac arrest and learning to do bystander CPR. 1:05:32 Can you share a happy moment or memory since the cardiac arrest event? 1:11:15 Flanary's message to listeners 1:16:15 Thank you, Kristin Flanary 1:18:32 Kristin Flanary, MA, is administrator and communications manager at Belin-Blank Center for Gifted Education & Talent Development at the University of Iowa. To read Flanary's article in Journal of Cardiac Failure, click here: https://www.onlinejcf.com/action/showPdf?pii=S1071-9164%2821%2900403-6. We'd love to hear from you! Send your comments/questions to Dr. Bhardwaj at podcast@healio.com. Follow us on Twitter @HealioPulm @abhi_bhardwaj99. You can follow Kristin Flanary on Twitter @LGlaucomflecken. Disclosures: Bhardwaj and Flanary report no relevant financial disclosures.
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-241 Overview: Seven percent of the US population has an active levothyroxine prescription, which is significantly greater than the number of people diagnosed with overt hypothyroidism. Many of these prescriptions appear to be for the treatment of subclinical hypothyroidism and other conditions in euthyroid individuals. Join us to uncover the latest findings on the use of levothyroxine and what the evidence tells us about appropriate use and misuse of this drug. Episode resource links: Brito, J., Ross, J., El Kawkgi, O., Maraka, S., Deng, Y., Shah, N., Lipska, K. & (9000). Levothyroxine Use in the United States, 2008-2018. JAMA Internal Medicine, Publish Ahead of Print, doi: 10.1001/jamainternmed.2021.2686. Johansen, M., Marcinek, J., Yun, J. & (2020). Thyroid Hormone Use in the United States, 1997–2016. Journal of the American Board of Family Medicine, 33 (2), 284-288. doi: 10.3122/jabfm.2020.02.190159. Jeffrey R. Garber, Rhoda H. Cobin,Hossein Gharib,James V. Hennessey, Irwin Klein, Jeffrey I. Mechanick, Rachel Pessah-Pollack, Peter A. Singer,Kenneth A. Woeber. Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association; November–December 2012. https://www.endocrinepractice.org/article/S1530-891X(20)43030-7/fulltext; https://www.endocrinepractice.org/action/showPdf?pii=S1530-891X%2820%2943030-7 Guest: Susan Feeney, DNP, FNP-BC, NP-C Music Credit: Richard Onorato
In this episode, we talk to Drs. Scott Zakaluzny and Daniel Nishijima from UC Davis Medical Center about what to do when your patient is on an anticoagulant, and what to do when your patient is on an anticoagulant you've never heard of -- and can't even pronouce. Resources: Daniel mentions this paper about how EMS ascertains whether a patient is on anticoagulation: Do EMS Providers Accurately Ascertain Anticoagulant and Antiplatelet Use in Older Adults with Head Trauma? CHEST guidelines: https://journal.chestnet.org/action/showPdf?pii=S0012-3692%2812%2960122-6 Country Hits is a production of Wisconsin's South Central Regional Trauma Advisory Council. Special thanks to the UC Davis Departments of Surgery and Emergency Medicine. Jonathan Kohler is @jekohler on Twitter and at RxCreative.
On today's edition of Spit and Twitches: The Animal Cognition Podcast, I'm joined by Aimee Sue Dunlap. She is an associate professor of biology at the University of Missouri at St. Louis.Aimee got her undergraduate degree in biology, history and English in 2000 from the University of Memphis and then her MS in biology from Northern Arizona University in 2002 and her PhD in ecology, evolution and behavior from the university of Minnesota in 2009. It should be noted that I'm making a concession to American spelling here and should be commended...Oh we also talked hockey. Including Liga hockey in Finland.Work in her lab focusses on the evolution of cognition and the adaptive value of cognition and memory, especially in bees. We talked about her experimental evolution work, as well as her field and lab stuff.mp3 download
Josh (@DrJIsrael) is joined by by Dr. Farzad Mostashari (@Farzad_MD), CEO and co-founder of Aledade, Dr. Kisha Davis (@kishadavismd), Aledade's Vice President of Health Equity, and Dr. Keith Winfrey, the Chief Medical Officer at Noela Community Health in New Orleans. They discuss the importance of controlling hypertension and Aledade's plan to improve blood pressure control and reduce disparities in hypertension control. For more information about hypertension, check out this article: https://www.ajpmonline.org/action/showPdf?pii=S0749-3797%2810%2900207-2
Symbols have an important role in the development of language throughout the centuries from hieroglyphics to the alphabets we know today, but within the occult community they also take on other meanings. Join the hosts as they talk about the science behind words and symbols in the occult. How accurate is the suggestion that a sigil is most effective when you destroy and forget? Is it possible to ever truly forget? Get lost in the murky waters of the unknown with us because its complicated.Come join our discord! https://discord.gg/kJthJyxTBcResources:Perceptions of perceptual symbols: https://www.cambridge.org/core/journals/behavioral-and-brain-sciences/article/abs/perceptions-of-perceptual-symbols/3F4B2D65B7685F18BF2C840E77761574Amodal/modal dichotomy of concepts (Review): https://link.springer.com/article/10.1007/s11097-020-09678-yBiological abnormality of impaired reading is constrained by culture: https://www.nature.com/articles/nature02865Brain mechanisms linking language and action: https://pubmed.ncbi.nlm.nih.gov/15959465/Language in context: https://pubmed.ncbi.nlm.nih.gov/15809000/Parallel memory systems...: https://pubmed.ncbi.nlm.nih.gov/16828565/From symbols to sounds: visual symbolic information activates sound representations: https://pubmed.ncbi.nlm.nih.gov/15318877/Neurochemical and neurological localization of semantic processes: https://www.cell.com/action/showPdf?pii=S1364-6613%2813%2900122-8Uses, misuses, new uses, and fundamental limitations of resonance imaging in cognitive science: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003851/Neuroimaging during trance state: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500298/The Demonstration of Short Term Consolidation (a concept similar to the burn and forget sigil activation): https://www.sciencedirect.com/science/article/abs/pii/S0010028598906843?via%3Dihub
In November 2020, Dr Marina Landau published an article in the Journal of American Academy of Dermatology describing an unnerving newly identified complication: morphea-like lesions following Botox injections.In this week's Aesthetics Mastery Show, Dr Tim explores what can only be described as a 'dent' effect in patients' foreheads; unpacks the likely cause; and explains the practical steps practitioners can take to avoid causing the side effect in the first place.Here are the articles Dr Tim mentions in the Show, starting with Dr Landau's research:https://www.jaadcasereports.org/article/S2352-5126(20)30632-9/fulltexthttps://www.sciencedirect.com/science/article/pii/S0022354919300863https://www.jaadcasereports.org/article/S2352-5126(20)30445-8/pdfhttps://www.jaad.org/action/showPdf?pii=S0190-9622%2819%2932460-0Sign up to Dr Tim's free webinar about how to free yourself from complications anxiety: https://www.aestheticcomplications.com/live-training#complications #medicalaesthetics #aesthetics
Body, Brain & Pain: Community Healing with Two Physical Therapists
Join Erin and Michelle as they discuss the importance of sleep hygiene. Sleep is not only one of the most important habits to prioritize for our general health and wellness, but sleep also greatly impacts the amount of pain we feel. We always say, “if you're not sleeping well, you're not healing well”. Listen to learn why we need to make sleep a daily routine and stick with it. References - Finan, P. H., Goodin, B. R., & Smith, M. T. (2013, December 1). The Association of Sleep and Pain: An Update and a Path Forward. Retrieved from https://www.jpain.org/action/showPdf?pii=S1526-5900%2813%2901199-1 - Nijs, J., Mairesse, O., Neu, D., Leysen, L., Danneels, L., Cagnie, B., . . . Goubert, D. (2018, February 07). Sleep Disturbances in Chronic Pain: Neurobiology, Assessment, and Treatment in Physical Therapist Practice. Retrieved January 07, 2021, from https://academic.oup.com/ptj/article/98/5/325/4841863 - Peterson, S. M., & Werneburg, B. L. (2018, May 18). Sleep: The foundation for healthy habits. Retrieved January 07, 2021, from https://www.mayoclinic.org/healthy-lifestyle/adult-health/in-depth/sleep-the-foundation-for-healthy-habits/art-20270117 - Plenke, M. (2020, November 10). There's one sleep trick that actually works. Here's the science behind why. Retrieved January 07, 2021, from https://www.mic.com/articles/128080/the-best-breathing-technique-to-help-you-sleep - Sivertsen, B., Lallukka, T., Steingrímsdóttir, Ó, Stubhaug, A., & Nielsen, C. (2015, August). Sleep and pain sensitivity in adults. Retrieved January 07, 2021, from https://journals.lww.com/pain/Abstract/2015/08000/Sleep_and_pain_sensitivity_in_adults.10.aspx Disclaimer: This podcast contains general information for community education purposes only, and does not take into account your specific comorbidities that your current healthcare provider may be managing. Please contact your care provider with questions regarding anything particular to you.
رنگ ساختاری گیاهان: https://www.cell.com/action/showPdf?pii=S0960-9822%2820%2930995-7 اثر امپمبا: https://www.pnas.org/content/pnas/116/31/15350.full.pdf حرکت اسپرم: https://advances.sciencemag.org/content/advances/6/31/eaba5168.full.pdf وجود آب توی عمق سیر یز: http://www.nature.com/articles/s41550-020-1146-8 یخچالهای طبیعی روی سطح مریخ: https://www.nature.com/articles/s41561-020-0618-x ذخیره انرژی با بلوک های بتنی: https://www.popularmechanics.com/technology/infrastructure/a29463165/concrete-block-energy-storage/ ابر خازن آجری : https://www.nature.com/articles/s41467-020-17708-1.pdf چاپ سه بعدی پلیمر رسانا: https://www.nature.com/articles/s41467-020-15316-7.pdf فرستادن تاردیگرید به فضا: https://linkinghub.elsevier.com/retrieve/pii/S0960982208008051 پروتئینهای محافظ دی ان ای تاردیگرید: http://www.nature.com/articles/s41598-020-70431-1 سیاهزخم ۲۳۰۰ ساله: https://www.bbc.com/news/world-europe-36951542 بررسی ایزوتوپی اسپایناسوروس : http://sourcedb.igg.cas.cn/cn/zjrck/200907/W020120622356922971023.pdf بررسی حرکت اسپایناسوروس: https://www.nature.com/articles/s41586-020-2190-3 دریاچه وستوک: https://astrobiology.nasa.gov/news/antarcticas-subglacial-lakes-support-prospects-for-life-on-icy-moons/ اکوسیستم غار آفریقای جنوبی: https://www.sciencemag.org/lookup/doi/10.1126/science.1127376 وجود باکتری در لایه های ۱۳-۱۰۴ میلیون ساله کف اقیانوس: https://www.nature.com/articles/s42003-020-0860-1.pdf رشد باکتری های ۱۰۰ میلیون ساله : https://www.nature.com/articles/s41467-020-17330-1.pdf موسیقی پس زمینه: URL: http://freemusicarchive.org/music/Augustus_Bro__Gallery_Six/EP_1079/Led_by_the_dress_colored_in_red Comments: http://freemusicarchive.org/ Curators: Music for Video, elementperspective Copyright: Attribution-NonCommercial-ShareAlike: http://creativecommons.org/licenses/by-nc-sa/3.0/
CDC: Interim Considerations for Infection Prevention and Control of Coronavirus Disease 2019 (COVID-19) in Inpatient Obstetric Healthcare Settings. Mullins et al. Coronavirus in pregnancy and delivery; rapid review. Accepted article. https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.22014 [Internet]. 2020. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women : a retrospective review of medical records. 2020;6736(20):1–7. Wang X, Zhou Z, Jianping Z, Zhu F, Tang Y, Shen X. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clin Infect Dis. 2020 Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. 2020;9(1):51–60 Rasmussen et al. Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know. AJOG 2020 https://www.ajog.org/action/showPdf?pii=S0002-9378%2820%2930197-6 Wu et al. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA 2020. Published online. https://jamanetwork.com/journals/jama/fullarticle/2762130
CDC: Interim Considerations for Infection Prevention and Control of Coronavirus Disease 2019 (COVID-19) in Inpatient Obstetric Healthcare Settings. Mullins et al. Coronavirus in pregnancy and delivery; rapid review. Accepted article. https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.22014 [Internet]. 2020. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women : a retrospective review of medical records. 2020;6736(20):1–7. Wang X, Zhou Z, Jianping Z, Zhu F, Tang Y, Shen X. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clin Infect Dis. 2020 Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. 2020;9(1):51–60 Rasmussen et al. Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know. AJOG 2020 https://www.ajog.org/action/showPdf?pii=S0002-9378%2820%2930197-6 Wu et al. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA 2020. Published online. https://jamanetwork.com/journals/jama/fullarticle/2762130
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