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In this episode of The Observatory, Jeff Low joins the show to discuss men's mental health and steps toward forging lifelong bonds and reconnecting with your purpose. Jeff founded Bonded Brotherhood, a safe space where men can connect, grow, and find strength in authentic community with the raw power of the outdoors. Hear Jeff's lowest moment and turning point into personal work and healing, his growth since meeting Scott and LaRae in February, and how working on himself has influenced his relationships. You will also learn the power of vulnerability and being in a community in your healing journey, and what Bonded Brotherhood is all about. Timestamps[03:37] Jeff Low's background information and what led him to what he is doing now[07:08] Jeff's biggest regrets in life [10:00] The pressure of growing a business[13:36] Jeff's turning point into personal healing[18:00] The thought of committing suicide in February 2025[23:57] Jeff's growth since meeting Scott and LaRae Wright[27:57] Working on yourself so that you can help others [29:03] How working on himself has influenced Jeff's relationship with his wife[33:00] The power of vulnerability and being in a community [34:32] The story of Bonded Brotherhood[41:45] What does Bonded Brotherhood do?[50:57] The future of Bonded Brotherhood[01:00:20] The importance of curiosity in your healing journey[01:04:00] Learning how to feelNotable quotes:“The gift that you two have of providing a loving, safe space 100% saved my life.” - Jeff Low [18:36]“You are not alone, you are not crazy for feeling and thinking the way you are feeling and thinking, and there is peace, and it comes by putting yourself first.” - Jeff Low [25:29]“You have to be healthy before showing up the best way for others.” - Jeff Low [26:24]“Bonded Brotherhood is all about building connection and support.” - Jeff Low [46:11]Relevant links:Bonded Brotherhood website: https://bondedbrotherhood.com/Instagram: https://www.instagram.com/bonded.brotherhood/Subscribe to the podcast: Apple PodcastProduced by NC Productions!
"I'd already finished my cardiovascular unit. I'd finished my pulmonary unit. I had never heard about this in any of my classes." That was Dr. Joel Bervell's reaction to discovering that a device used every day in hospitals -- the pulse oximeter -- reads less accurately on darker skin tones. He posted a 30-second video about this consequential discrepancy that, to his utter surprise, gained over 500,000 views by the next morning. That video launched Dr. Bervell into orbit as a social media presence and created his identity as The Medical Mythbuster. In just a few years, he's built a following of two million people, earned a Peabody Award and was named to the inaugural Time 100 Creators list, all while finishing his residency. On this episode of Raise the Line, host Lindsey Smith welcomes Dr. Bervell to explore the roots of this kind of bias and the real world impact of drawing attention to it. “The most impactful biases in medicine exist because no one stops to ask who was included in the original data and who was left out,” Dr. Bervell explains. Stay tuned to also learn about: His YouTube animated series The Doctor is In which helps kids understand how their bodies work, as well as providing medical role models; How to build trust with marginalized communities; His forthcoming book, The Default Body which examines who medicine was actually designed for. Mentioned in this episode:Dr. Bervell on InstagramTikTok ChannelFacebook"The Doctor Is In" Show If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
Rick Alexander is a depth-psychological counselor, psychedelic practitioner, and interfaith spiritual care provider currently completing his Ph.D. in Mythology/Depth Psychology and a former Naval Special Operations combat medic. Rick was a Special Operations combat medic until a single psychedelic experience shattered his worldview and sent him back to school to study psychedelic spiritual care. He and Dr. Mike dig into neuroplasticity windows, why “good trip/bad trip” is the wrong question, and what may really be happening in DMT space. Expect to learn how a rough teenage salvia trip and a later psilocybin experience redirected Rick's entire career, what life is really like as a Special Operations Combat Medic supporting SEALs and Green Berets, why military training narrows emotional range and makes civilian re-entry so hard, how integration (not the trip itself) determines whether a psychedelic experience heals or destabilizes you, what the "third wave" of psychedelic science gets right that the DSM's "hallucinogen" label gets wrong, whether neuroplastic windows could help athletes learn skills faster, and what a brutal 5-MeO-DMT experience taught Rick about his own running form and breathing. Connect with Rick: Website Instagram Episodes you'll enjoy next: #47 — Tools to Down-Regulate in Response to Stress (an earlier conversation with Rick Alexander): Listen here #194 — The Pros and Cons of Psychedelic Compounds with Psychedelic Researcher Rebekah Senanayake: Listen here Episode Timestamps: 2:49 – Rick's PhD progress and the psychedelic experience that redirected his career 3:38 – A rough first psychedelic experience with salvia at 18 4:46 – The psilocybin experience that "peeled back" his worldview 7:00 – Life as a Special Operations Combat Medic supporting SEALs and Green Berets 8:23 – How military training narrows emotional range and worldview 10:01 – Why veterans struggle to re-enter civilian life after specialized training 13:34 – The double-edged sword: psychedelics can destabilize as easily as they heal 14:32 – The "third wave" of psychedelic science and the flawed DSM "hallucinogen" label 23:49 – Integration: do you have time to process what comes up? 24:43 – "Psychedelic myth-making" and building a new personal mythology 31:05 – Could neuroplastic windows help athletes learn skills faster? 37:01 – Yogic energy channels (nadis) and psychedelics amplifying subtle perception 39:17 – How a brutal 5-MeO-DMT trip changed Rick's running form and breathing 56:16 – What's really happening in DMT space: Strassman, Gallimore, and "reality switch technologies" 59:43 – Henri Corbin's "psycho-cosmology": consciousness and reality as mirrored levels 1:06:45 – "Functional consequentialism": why you shouldn't dismiss someone else's experience 1:10:46 – Where to find Rick and his counseling and breathwork work Get the Daily Fitness Insider newsletter (free): https://www.miketnelson.com/newsletter
In this episode of The Observatory, Samuel Beautysta joins the show to discuss the ancient art of Zapotec weaving and the living stories carried in each thread. Samuel, a traveling weaver from Oaxaca, Mexico, shares how his curiosity about identity and lineage led him deep into the Benizaa tradition, uncovering the meanings behind patterns, the natural colors drawn from the earth, and the symbols that honor life, death, and ancestry. He reflects on his family's response to his search for knowledge, his experiences traveling and teaching, and how weaving becomes a language that connects cultures and generations. Timestamps[02:31] How Scott and LaRae first met Samuel Bautista[05:36] Samuel's background information on the weaving culture and tradition[13:33] How things unfolded for Samuel after the curiosity of wanting to know who he is[19:02] Samuel's experience in the United Kingdom[20:10] The similarities of Samuel's culture to that of other cultures during his research[25:46] How Samuel's parents reacted to his journey of seeking knowledge about their tradition [29:11] How Samuel discovered the natural colours of weaving[38:43] Samuel's episode on The Reluctant Traveler Show about the Day of the Dead[49:27] Connecting to one another and the Mother Earth[55:34] How Samuel created a community of collaboration and co-creationNotable quotes:“History is always written with an agenda and a hidden power, like governments and institutions. It's up to us to answer questions for ourselves, who we are, our lineage, and our story.” - Samuel Beautysta [11:59]“When we start to discover that we are more similar than we are different, it changes our whole perspective on what our parents taught us.” - LaRae Wright [25:46]“To survive the hottest days of summer, you have to feed your roots, your ancestors, and remember your teachings.” - [43:25]“For us, instead of fearing death, we embraced it and added it to our symbols and rituals.” - Samuel Beautysta [50:38]“All the knowledge is lying dormant within you, just like a seed that is buried in the ground and ready to sprout. ” - Samuel Beautysta [01:07:42]Relevant links:Samuel Beautysta Website: https://dixza.com/Instagram: https://www.instagram.com/sam_dixza/?hl=enFacebook: https://www.facebook.com/dixzarugsSubscribe to the podcast: Apple PodcastsProduced by NC Productions
Despite gains in recent years, Black, Hispanic, and Asian communities are still under-represented in the U.S. nursing workforce. We're going to explore that gap and how to close it on this episode of Raise the Line from Elsevier with Dr. Ernest Grant, Vice Dean for Diversity, Equity, Inclusion and Belonging at the Duke University School of Nursing. "You get a patient who is more compliant when they see someone who looks like them, who is from their culture and who can advocate on their behalf," he tells host Lindsey Smith. Dr. Grant bases that and other insights on a rich professional background that includes 50 years in nursing, being a leading advocate for his profession and breaking down barriers himself as a male nurse of color and the first man elected president of the American Nurses Association. In this thoughtful conversation, Dr. Grant reflects on what it took to earn credibility in leadership roles, how he's navigating the political climate on DEI initiatives, and the causes and solutions to the persistent shortage in nursing faculty, among other pressing issues. Tune in for a uniquely-informed look at what it will take to build a stronger, more representative nursing profession. Mentioned in this episode: Duke University School of Nursing American Nurses Association If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
Surveillance camera critics rally in Seattle as company tightens safeguards. Kent officers arrest child rape suspect after ALPR alert during routine patrol. New poll: 75% of Seattleites support CCTV cameras, expansion in wake of multiple shootings. Shootout at Pioneer Square bar prompts questions on offline CCTV camera. Harger: Auburn Police arrested five shoplifters at Fred Meyer and booked them into jail. Here’s why that matters more than you think // Puget Sound VA involved in a federal psychedelic research push. VA launches psilocybin trial for Veterans with treatment-resistant depression // LETTERS
In episode 551 I chat with Andrew who has kindly agreed to share his story with us. We discuss his story, how a bad experience with psilocybin triggered his OCD, trying to control thoughts, medication, acceptance and commitment therapy (ACT), sexual orientation themed OCD, compassion focused therapy (CFT), internal family systems therapy (IFS), working with parts of himself, meditation, and much more. Hope it helps. Show notes: https://theocdstories.com/episode/andrew-551 The podcast is made possible by NOCD. NOCD offers effective, convenient therapy available in the US and outside the US. To find out more about NOCD, their therapy plans and if they currently take your insurance head over to https://go.treatmyocd.com/theocdstories Join many other listeners getting our weekly emails. Never miss a podcast episode or update: https://theocdstories.com/newsletter
Eric Osborne is the Co-founder and Head Minister of Psanctuary ( https://www.psanctuary.org/ ), a sacred mushroom church based in Louisville, Kentucky. Eric joins me on the podcast today to discuss his pioneering work in the international mushroom indu...
In remembrance of Carol Lynn Pearson, we are honored to reshare this October 2023 conversation and celebrate the extraordinary legacy she leaves behind as a writer, poet, advocate, and courageous voice for love, faith, women, and the LGBTQ community.In this episode of The Observatory, Carol Lynn Pearson joins the show to talk about the doctrine of plural marriage in Mormonism. Hear about how the doctrine of polygamy developed, how polygamy causes irreversible damage, the importance of resonating with love, practical solutions to the problem, and Carol's upcoming books. Timestamps[03:53] Have Carol Lynn's views changed on the doctrine of polygamy.[10:14] Mormonism and polygamy.[18:00] How the doctrine changed over time. [21:11] How polygamy showed up in Carol Lynn's story.[26:54] The damage that this doctrine causes.[44:27] Resonating with love.[51:30] Carol Lynn's favorite passages. [70:41] Solutions to the problem.[74:15] Carol Lynn's diaries. Notable quotes:“It benefits no one.” – Carol Lynn Pearson [04:27]“However we deal with the past, it is the past.” – Carol Lynn Pearson [26:48]“Society must move historically into more and more of a place of light.” – Carol Lynn Pearson [72:15]Relevant Links:Website: carollynnpearson.comSubscribe to the podcast: Apple PodcastProduced by NC Productions
What does it take to compete on the world's biggest stage and then pivot to one of the most demanding training paths in professional life? Today's guest, Samantha "Sammy" Kolowrat, has done both, and she has some fascinating insights into the commonalities of those two worlds on this episode of Raise the Line. “Something that really drew me to medicine is the team atmosphere that's there as you work towards a common goal, and there's this level of intensity that's very reminiscent of the experiences I had as a professional athlete.” Originally from Prague, Kolowrat represented Czechia at six IIHF Women's World Championships and the 2022 Beijing Olympics, and also captained the Division I women's hockey team at the University of Vermont while earning degrees in biology and pharmacology. As she starts an anesthesiology residency at Vanderbilt University, she credits her athletic career with shaping how she handles pressure, feedback, and teamwork in medicine. "The more I improve, the more knowledge I acquire, the more skills I hone, the better care my patients get," she tells host Lindsey Smith, describing what drew her to a field that rewards the same relentless fine-tuning as elite sports. This engaging conversation also explores: How crippling performance anxiety as a Division I athlete ended up preparing Kolowrat for the operating room; Why she was drawn to anesthesiology's "well-oiled machine" atmosphere; The mentorship gap she's working to close for the next generation of athlete-physicians. Mentioned in this episode: Vanderbilt University Anesthesiology Residency Program If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
"Living life from a different perspective heals the past and also paves the way for the future as well." In this episode, Heather and Eddy Tony explore what it really means to heal, not by becoming someone new, but by integrating the parts of yourself you've spent years trying to outrun. This conversation challenges the idea that transformation comes from a single breakthrough or magic solution, inviting us to consider a gentler process of awareness, compassion, and daily practice. At its heart, this episode is an invitation to trust your own unfolding, soften into the process of becoming, and discover that healing comes from welcoming every part of yourself home, rather than erasing who you've been or clinging to outdated identities. What to listen for: ☑️ How we can change our identity, personality, and how we feel emotionally ☑️ There's no magic bullet for healing, but there is a process to get lasting change ☑️ Why you need to see it, feel it, balance it, and integrate it to step out of old loops "There is no magic bullet. Where psychedelics are really great at is seeing it, increasing awareness within yourself about old patterns, loops, and behaviors." ☑️ Why everything bubbles up to the surface when it's ready to be transformed ☑️ Navigating the grief of letting go of your former identity and stepping into freedom ☑️ How to commune with the parts you're releasing with deep compassion "The grieving dissolves and happens on its own because that part also has a home within yourself, within themselves. As opposed to extracting that part, they can integrate and soften back into wholeness." ☑️ Healing doesn't have to be heavy; oftentimes, it's in the small daily decisions ☑️ Looking for the positives inside of challenges, and how that helps us heal ☑️ Coming into full coherence and acceptance, removing the inner war "It doesn't have to feel so heavy. So leaning into what is happening and seeing the positives that are coming out of it as well. It's about bringing the person into full coherence of what is actually going on." ☑️ Where psilocybin or psychedelics come in and how they create more freedom ☑️ Taking the tips and wisdom of our natural world and applying it to ourselves ☑️ How the intention to release and let go can change your life Be sure to also listen to episodes 1191, 1203, and 1236 for more! About Eddy Tony: Founder. Author. Guide to over a thousand individuals. The person people turn to when trying harder stops working. Eddy Tony helps his clients release the unconscious pressure patterns that keep life from feeling fulfilling. Known for his calm precision and depth, he guides people back into self-trust, emotional steadiness, and success that finally feels aligned and fully lived. Connect with Eddy: https://www.eddytony.com/ https://www.instagram.com/eddytony https://www.facebook.com/eddytony/ *** For those of you who are ready to stop feeling drained, overextended, and out of alignment… join me inside the Energetic Time Management Accelerator, a focused experience designed to help high-achieving women uncover what's draining them, clarify what truly matters, and create a simple plan that fits their life. We'll pinpoint your biggest time + energy leaks, identify the top areas to focus on for quick momentum, and map out exactly what to let go of so you can reclaim your energy, your time, and your joy. Ready to make your time work for you without adding more to your plate? Join the Energetic Time Management Accelerator: www.heatherchauvin.com/time Explore the top episodes listeners come back to when they're stuck, burned out, or standing at the edge of a big shift: www.heatherchauvin.com/10 Follow Heather on Instagram: www.instagram.com/heatherchauvin_
The Psychedelic Entrepreneur - Medicine for These Times with Beth Weinstein
Jason Grechanik is a master tabaquero trained in the Mamankunawa tradition under curandero Don Ernesto Garcia Torres, with nearly a decade immersed in Amazonian plant medicine traditions. He worked for years at the Temple of the Way of Light, one of the world's most respected Shipibo healing centers. He is the co-founder of the Nicotiana Rustica project — bridging Amazonian sacred tobacco traditions with Celtic tree wisdom — and the host of The Universe Within Podcast, with 180+ episodes and 20,000+ monthly listeners. Jason has guided over 1,000 people through plant medicine work, been featured in DoubleBlind Magazine, and appeared on 30+ podcasts globally. He brings lineage, ethics, and depth to every conversation. Episode Highlights ▶ Jason's journey from a Santo Daime friend's influence to an unignorable calling into the Peruvian Amazon ▶ Life at the Temple of the Way of Light and the facilitator's role as a bridge between Shipibo and Western worldviews ▶ Tobacco as the "first plant" in Amazonian origin myths, a gateway to the wider plant world ▶ The real difference between tobacco and cigarettes, and the limits of a purely reductionist, molecule-focused view ▶ How tobacco moves through the body in dieta, often surfacing in dreams as movement through dark, blocked places ▶ Why trees are considered the deeper teachers, and what their age and rootedness offer that other plants don't ▶ Tobacco as portal, trees as ongoing teacher: how the two work together in dieta ▶ Ancestral knowledge, the limits of modern assumptions, and building a new maloka, a new earth Jason Grechanik's Links & Resources ▶ https://www.jasongrechanik.com ▶ https://www.nicotianarustica.org ▶ https://www.theuniversewithin.com ▶ Instagram: https://www.instagram.com/jasongrechanik Download Beth's free trainings here: Clarity to Clients: Start & Grow a Transformational Coaching, Healing, Spiritual, or Psychedelic Business: https://bethaweinstein.com/grow-your-spiritual-business Integrating Psychedelics & Sacred Medicines Into Business: https://bethaweinstein.com/psychedelics-in-business ▶ Beth's Coaching & Guidance: https://bethaweinstein.com/coaching ▶ Beth's Offerings & Courses: https://bethaweinstein.com/services ▶ Instagram: @bethaweinstein ▶ FB: / bethw.nyc + bethweinsteinbiz Download Beth's free trainings here: Clarity to Clients: Start & Grow a Transformational Coaching, Healing, Spiritual, or Psychedelic Business: https://bethaweinstein.com/grow-your-spiritual-businessIntegrating Psychedelics & Sacred Medicines Into Business: https://bethaweinstein.com/psychedelics-in-business▶ Beth's Coaching & Guidance: https://bethaweinstein.com/coaching ▶ Beth's Offerings & Courses: https://bethaweinstein.com/services▶ Instagram: @bethaweinstein ▶ FB: / bethw.nyc + bethweinsteinbiz
In this powerful episode of Giving Pain Purpose, Lyndsay Soprano sits down with entrepreneur, filmmaker, and psychedelic wellness advocate Zappy Zapolin for a conversation about trauma, chronic pain, and the evolving world of psychedelic-assisted healing.Together, they explore why so many people continue to struggle despite years of traditional treatments and how emerging research is changing the way we think about healing the mind and body. Zappy shares his own transformational journey and offers insight into the unique roles different psychedelic medicines may play in addressing trauma, addiction, depression, anxiety, and chronic pain.Throughout the episode, Lyndsay reflects on her own healing journey and the hope that can emerge when we're willing to explore new possibilities.This conversation is honest, inspiring, and a reminder that healing isn't always about finding another treatment—sometimes it's about discovering an entirely new path forward.Episode Highlights:(00:01) Lyndsay opens up about anxiety, alcohol, and ketamine therapy(02:48) Zappy's vision for psychedelic healing(04:15) Introducing Zappy Zapolin(05:13) Zappy's first psychedelic experience(06:15) From Wall Street to the jungle(08:00) The Reality of Truth and 25 million views(09:30) Meeting God in the jungle(11:00) How ibogaine works and what to expect(14:00) Ayahuasca, psilocybin, and combo explained(20:00) Lois's story from near death to fully healed(26:00) The caterpillar death spiral(32:00) How to start with microdosing(37:00) The CRPS community and why plant medicine matters(38:02) Finding perspective through a mushroom journey(40:21) Don't wait for your doctor(41:04) Where to find Zappy and closing thoughtsFind Zappy Zapolin Online Here:Website: psychedelicconcierge.comInstagram: @zappyzapolinYouTube: @PsychedelicConceirgeLinkedIn: Zappy ZapolinPodcast: Psychedelic Concierge PodcastFind Giving Pain Purpose Online Here:Website: givingpainpurpose.comInstagram: @givingpainpurposeFacebook: The Giving Pain Purpose PodcastLinkedIn: Lyndsay SopranoYouTube: @givingpainpurposeShop: thegivingpainpurposeshop.comSubscribe on YouTube | Merch Shop is OPEN!! | COMING SOON: The Pain Hub - A Women's Healing Community. Subscribe Now!Unfiltered convos. Dark humor. Real healing. This is where pain meets purpose — and you're not doing it alone.++Want to be a guest on Giving Pain Purpose with Lyndsay Soprano? Send her a message on PodMatch, here: Be a Guest on The Show
Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today's episode delves into the latest innovations and strategic shifts propelling the industry forward. A notable dialogue emerging in psychiatric drug development comes from TLDR Biotech's engagement with Shlomi Raz and Ken Belotsky, co-founders of Palomar Labs. This conversation heralds a transformative shift in psychiatric treatments, moving beyond traditional psychedelics toward novel approaches deeply rooted in human experience. Initially inspired by the therapeutic potential of psychedelics such as psilocybin, early research, notably from Johns Hopkins, sought to establish these compounds within a biopharmaceutical framework. Despite historical evidence supporting their efficacy, challenges persisted in reclassifying these Schedule I substances as viable therapies. Raz and Belotsky, pioneers in this initial psychedelic wave, now lead efforts at Palomar Labs to develop next-generation therapeutics targeting serotonin receptors without the hallucinogenic effects typical of classical psychedelics. This approach seeks to dismantle longstanding industry biases against specific receptor targets known as "anti-targets." A critical concept in their methodology is "neuroplastogens," as popularized by David Olson at UC Davis. These compounds are believed to induce beneficial neuroplastic changes without causing hallucinations. However, Palomar Labs exercises caution, viewing neuroplasticity not as a definitive biomarker for therapeutic efficacy but rather as one of many aspects to consider. Their unconventional "reverse" drug development model begins with anecdotal human experiences and is validated backward through preclinical animal models before advancing to clinical trials. This method relies on overlooked data sources—such as discarded trial reports and traditional medicine use cases—to uncover therapeutic candidates traditionally ignored due to biases against certain receptor targets. For example, they explore therapies for Parkinson's disease bypassing direct dopamine receptor modulation and treatments for Alzheimer's-related aggression avoiding heavily sedative antipsychotics. Palomar Labs' venture studio model emphasizes disciplined capital allocation and an unbiased approach to research outcomes. By prioritizing drug candidates with strong evidence from human experiences, they aim to swiftly advance promising therapies to proof-of-concept stages, readying them for further development by pharmaceutical partners or venture-backed entities. This paradigm shift from target-centric development to a model grounded in empirical human data represents a significant advancement in psychiatric drug discovery. In other industry news, Replimune has successfully navigated regulatory hurdles to secure FDA approval for its melanoma therapy, Tudriqev, following two prior rejections. This achievement underscores the resilience required in drug development and strategic regulatory engagement. The approval highlights the potential of oncolytic virus therapies—Tudriqev employs an innovative approach by using viruses to selectively infect cancer cells while sparing healthy tissue, simultaneously stimulating an immune response. Meanwhile, Eli Lilly continues its dominance in the obesity treatment market with Zepbound, despite new oral competitors. The enduring preference for injectable solutions highlights established efficacy and safety profiles that continue to resonate with healthcare professionals. In China, TransThera has gained regulatory approval for a bile duct cancer treatment, marking a significant step forward for Chinese innovation in oncology. Such advancements not only diversify treatment options but also elevate China's status as a pivotal contributor to global drug development. Challenges persist across the sector, exemplified by Fresenius Kabi's recall of a mislabeled morphine lot due to overdose risks. This incident underscores the vital importance of stringent quality control measures essential for patient safety. The biopharmaceutical landscape also sees Takeda securing FDA approval for its first-in-class orexin receptor agonist targeting narcolepsy—a testament to innovative approaches addressing unmet needs in sleep disorders. Amidst these developments, BioMarin has opted to terminate its $270 million rare disease asset following unsatisfactory Phase 3 results. Such decisions highlight the inherent risks within drug development pipelines and underscore the necessity for strategic flexibility. Leadership changes are shaping corporate trajectories too; BioNTech's appointment of Guido Oelkers as CEO exemplifies this trend. His experience will likely drive strategic realignments crucial for navigating complex industry challenges. Finally, the industry's focus on digital transformation is evident through Bausch + Lomb's partnership with VerilyMe—a collaboration aimed at enhancing dry eye education via digital and AI technologies. These stories collectively embody the dynamic nature of the pharmaceutical and biotech industries—where regulatory achievements, strategic pivots, and technological advancements are continuously redefining therapeutic landscapes and enhancing patient care worldwide. As we continue navigating this rapidly evolving field, staying informed on these developments is crucial for leveraging opportunities and addressing challenges within this innovative sector.Support the show
This episode of the podcast is going to explore what actually happens inside psilocybin assisted therapy, from the first conversation to the last integration session. Specifically, we are going to be walking the entire arc of a legal psilocybin therapy engagement through the lens of naturopathic medicine: preparation, the session itself, integration, the risks, and how to tell whether any of it is right for you. Our guest is Dr. JJ Pursell. What You'll Learn About:
An 11-year-old boy in rural Zambia once told Dr. Genesis Mwamba that he was about to attend school wearing shoes for the first time in his life. That moment, Dr. Mwamba says, crystallized why he started the Lead Me Back Foundation to provide school supplies and other support to marginalized communities in his native country. As you'll learn in this inspiring installment in our NextGen Journeys series, Dr. Mwamba started the foundation in 2021while still a medical student because he had experienced the power of education as an “equalizer” in his own life, taking him from humble roots to a career in medicine. He and his colleagues have grown the bootstrapped organization to a point where it now provides hundreds of thousands of people across the country with educational access, climate education and community health clinics. “I've always been drawn to opportunities and initiatives that bring help to humankind,” he tells Raise the Line host Dr. Parsa Mohri. This episode also explores: What building "with" a community rather than "for" it looks like in practice; The storytelling strategy that attracted donors and partners; How his mother's untimely death inspired his commitment to preventive medicine. Mentioned in this episode: Lead Me Back Foundation If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
Why does a man with everything going right for him quietly fall apart on the inside? Jeremy Lipkowitz was a PhD student at Duke studying the genetic code that supposedly explains what a human being is. On the outside it looked like a life going exactly to plan. In private he was losing to a compulsion nobody around him knew about, and the more he achieved the worse it got. Eventually he stopped trying to fix himself from the outside, left the program, flew to Myanmar, and ordained as a monk.He has spent the last decade teaching men to do what he did, without religion, dogma, or drugs. His show is Unhooked and his work is at https://unhookedacademy.com/We talk about where shame actually comes from, what happens to you around day four of a silent retreat, and whether moderation is possible with anything engineered to hook you. Late in the episode we get into whether there is anything behind all of this. He says no. I made my case anyway. Neither of us moved, and that exchange might be my favorite part of the conversation.
The first U.S. clinical trial of psilocybin-assisted therapy in veterans with PTSD who got no relief from conventional treatments has established that the protocol is safe, causing no serious adverse events or increases in suicidal thinking or behavior. In fact, the preliminary clinical results exceeded researchers' expectations. Joining me to discuss psilocybin-assisted therapy and PTSD and the study published in the journal Communications Medicine is Stacey Armstrong , PhD. Dr Armstrong is the Associate Director and Senior Researcher at the Center for Psychedelic Drug Research and Education (CPDRE) at The Ohio State University Safety, feasibility, and preliminary clinical outcomes of psilocybin-assisted therapy for veterans with severe, treatment-resistant PTSD: an open-label pilot clinical trial
Before we get into our next topic .. we want to let you know we're going to be talking about anorexia .. we know for many this can be a distressing topic, so this might be triggering for some. If you or someone you know is struggling with an eating disorder, you can call Heathline on 0800 611 16 24 hours a day, seven days a week. Psilocybin is an active ingredient in magic mushrooms .. which some of you might know that better than others. My next guest, University of Auckland's Dr Hannah Douglas, has just published the results of a trial using the drug to help in Anorexia recovery. [picture id="4MOTWU2_copyright_image_238827" crop="16x10" layout="full"]
This is the first of a two part summer special with Laura Mae Northrup, who was first featured in the original BFTA summer special back in 2022. In this first episode, in an excerpt from her wonderful podcast called Inside Eyes, we hear Laura describe her long and grueling battle with suicidality, which emerged as a result of childhood sexual abuse. In the second episode in two weeks, Laura and Dr. H dive deep into her personal healing journey— what worked, what didn't, and how she was able to finally put her chronic suicidality to rest. Support the showLaura Mae Northruphttps://www.lauramaenorthrup.com/Elemental Psychedelicshttps://www.elementalpsychedelics.com/Explore every episode through themes, domains, formats, and speakers. The BFTA CODEX is a listener-built and curated field guide to the podcast. https://bfta-codex.orgBFTA episode recommendations/Podcast pagehttps://www.craigheacockmd.com/podcast-page/BFTA on IG @backfromtheabysspodcasthttps://www.instagram.com/backfromtheabysspodcast/Support the show
Psychedelics, hallucinogens, natural medicines, you name it, we're covering it on this episode of the Pain Pod folks! We'll chat through all types of psychedelics including LSD, MDMA, Psilocybin, DMT, and Ketamine and beyond. No trippin' just learnin'! You're not going to want to miss this one! Come one, come all, to the Pain Pod!!! Pain Guy www.painguy.us
In this episode of The Observatory, Gina Scarpino joins the show to discuss her journey as a psychic medium, the reality of communicating with the other side, and how emerging mediums can confidently develop their gifts. Gina is a Psychic Medium & Spiritual Life Coach who has dedicated her life to uplifting the spirits of others. She shares her first telepathic connection with her grandfather after his passing, how her calling unfolded, and why she feels compelled to support others on a similar path. Timestamps[02:00] Gina's Journey to being a Psychic Medium[04:20] The telepathic connection that Gina had with her dead grandfather[07:57] Gina's why in her Psychic Medium work[09:46] Gina's experience with other mediums in England[13:00] What ‘Psychic' and ‘Medium' means[20:54] Gina's biggest lesson of healing[22:17] How Gina engages with people spiritually[30:11] Gina's experience of teaching 30 students while grieving[34:41] How does medium training look?[38:13] The things that Gina loves doing that keep her energized[44:39] The ‘Charmed to Life Project' Podcast[54:05] Balancing the feminine and masculine[55:40] Gina's revelation about Scott and LaRae WrightNotable quotes:“The term 'medium' means you can communicate with people that have crossed over to the other side.” - Gina Scarpino [13:09]“Where there is a will, there is a way, and you're always guided to where you need to be.” - Gina Scarpino [36:40]“When you bring in the science element to all the spiritual subjects, it gives you something concrete when the spiritual aspect is more fluid.” - Gina Scarpino [46:52]Relevant links:Gina Scarpino Website: https://www.ginajulianscarpino.com/Facebook: https://www.facebook.com/GinaScarpinoPsychicMediumPodcast: https://podcasts.apple.com/us/podcast/the-charmed-life-project/id1829457788Subscribe to the podcast: Apple PodcastProduced by NC Productions
"We have an untapped army of 200,000 PAs that really could step up and drive some change in the healthcare system if we weren't restricted,” says Dr. Jennifer Kolb, capturing her motivation for pushing to update practice regulations for physician associates that date back more than 50 years. As Chief Medical Officer and Senior Vice President of Clinical Affairs at the American Academy of Physician Associates, Dr. Kolb has been in the middle of the fight at the state and federal level to grant PAs more independence from physicians, full billing rights, and the increased ability to practice across state lines, among other changes. In this pertinent conversation with Raise the Line host Lindsey Smith, Dr. Kolb explains how these updates could help close huge gaps in access to healthcare, better manage the fight against chronic diseases and improve patient outcomes. Dr. Kolb also addresses: Why the name shift from "assistant" to "associate" took her years to fully appreciate; How a 10-year gap in life expectancy across Chicago zip codes shapes her view of health equity; Why PA's shouldn't wait for permission to start making change in their communities. Mentioned in this episode:American Academy of Physician Associates If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
Psychedelics, hallucinogens, natural medicines, you name it, we're covering it on this episode of the Pain Pod folks! We'll chat through all types of psychedelics including LSD, MDMA, Psilocybin, DMT, and Ketamine and beyond. No trippin' just learnin'! You're not going to want to miss this one! Come one, come all, to the Pain Pod!!! Pain Guy www.painguy.us
Send us Fan MailCan magic mushrooms unlock the meaning of life—or lure seekers to the edge of madness?Award-winning journalist and bestselling author John O'Connor returns with a gripping investigation into the untold story of modern psychedelics, spirituality, and the mysteries of belief. From NPR and Chicago Tribune's “Best Books of 2024” author, this conversation dives deep into O'Connor's new release, A Short Strange Trip: An Untold Story of Magic Mushrooms, Madness, and a Search for the Meaning of Life in the Amazon.In this revealing episode, John O'Connor explores:How his fascination with unconventional beliefs and subcultures—from Bigfoot to psychedelic explorers—shaped his approach to storytellingWhat he uncovered about the complicated relationship between belief, disbelief, and the human longing for the extraordinaryThe forgotten legacy of Terence McKenna and his brother Dennis, who first unlocked home cultivation of magic mushrooms—and transformed the psychedelic undergroundThe role of sacred, indigenous traditions versus the romanticized wellness narratives dominating Western psychedelic cultureHis father's struggle with addiction and why psychedelic therapies are no quick fix for sufferingWhy stories of divine intelligence, “little people,” and multidimensional encounters on psychedelics demand both open-mindedness and investigative rigorHow the booming billion-dollar psychedelic industry raises urgent questions about access, authenticity, and the future of mental healthWhat seekers must remember about shortcuts to healing, enlightenment, and meaningJohn O'Connor's nuanced, compassionate journalism asks: What if the border between spiritual revelation and psychological destabilization is thinner than we think? Whether you're curious about altered states, seeking hope for mental health, or navigating the intersection of science and spirituality, you'll find insight, caution, and inspiration in this episode's search for meaning at the edge of belief.If this sparked new questions for you, subscribe for more, share the episode with a friend who's curious about psychedelics and spirituality, and leave a review so more listeners can find the show. Support the showSpiritual Spotlight Series is hosted by Rachel Garrett, RN, CCH — Akashic Records Practitioner, Master Energy Healer, and Certified Crystal Healer.Conversations about the things we almost don't say out loud. For the ones who feel everything — but question it.Each episode features real stories of spiritual awakening, healing, and transformation from guests across all walks of life, alongside solo teachings on Akashic Records, crystal healing, nervous system support, and intuitive development.Healing doesn't have to be heavy.New: Join the monthly live Akashic reading → YouTube membership at $4.99/month → youtube.com/@rachelgarrett/membership✨ Explore More Spiritual Wisdom & Stay Connected
Psychedelic Therapy for Mental Health: Research, Safety, and the Path to FDA Approval: Dr. Will Van Derveer and Keith Kurlander, co-authors of “Psychedelic Therapy: A Revolutionary Approach to Restoring Your Mental Health and Reclaiming Your Life,” reveal the shift from recreational psychedelics to structured, research-based psychedelic-assisted therapy for conditions like PTSD, depression, and anxiety. Van Derveer describes limitations of conventional psychiatry (citing STAR*D remission rates) and his entry into MDMA-assisted PTSD research after promising results. They contrast controlled clinical protocols—screening, preparation, safe setting, trained facilitation, medical monitoring, and post-session integration—with uncontained recreational use. The discussion covers current policy momentum under Trump and RFK Jr., VA interest for veterans, and key agents: ketamine (including abuse risks and clinic-only Spravato), MDMA (phase 3 but not approved in 2024), psilocybin (phase 3, potential FDA approval), LSD (GAD trials), ibogaine (arrhythmia risk, Mexico clinics), ayahuasca, peyote, and microdosing. They also note commercialization, including Eli Lilly's acquisition of a 5-MeO-DMT nasal spray developer, and emphasize an integrative “all-of-the-above” mental health approach.
The Psychedelic Entrepreneur - Medicine for These Times with Beth Weinstein
Benjamin Forest is a retired military officer turned psychedelic author, speaker, and coach. His transformation began with a life-changing psilocybin journey that lifted him from decades of depression and into a radically new way of living. After his own awakening through plant medicine, he began writing, speaking, and coaching around the subject. In 2025, he published his first book: "Trip of a Lifetime -- The Psychedelic Guide to Healing, Loving, and Living." Episode Highlights ▶ Military service and discipline ▶ Psychedelic experiences and healing ▶ Systemic challenges in veteran mental health ▶ The role of psychedelics in redefining masculinity ▶ Preparation and integration of psychedelic journeys Benjamin Forest's Links & Resources ▶ Website: www.benjaminforest.com ▶ Instagram: www.instagram.com/benjamin.forest.bliss ▶Buy his book: https://www.amazon.com/dp/B0FPDPXXXD/ Download Beth's free trainings here: Clarity to Clients: Start & Grow a Transformational Coaching, Healing, Spiritual, or Psychedelic Business: https://bethaweinstein.com/grow-your-spiritual-business Integrating Psychedelics & Sacred Medicines Into Business: https://bethaweinstein.com/psychedelics-in-business ▶ Beth's Coaching & Guidance: https://bethaweinstein.com/coaching ▶ Beth's Offerings & Courses: https://bethaweinstein.com/services ▶ Instagram: @bethaweinstein ▶ FB: / bethw.nyc + bethweinsteinbiz Download Beth's free trainings here: Clarity to Clients: Start & Grow a Transformational Coaching, Healing, Spiritual, or Psychedelic Business: https://bethaweinstein.com/grow-your-spiritual-businessIntegrating Psychedelics & Sacred Medicines Into Business: https://bethaweinstein.com/psychedelics-in-business▶ Beth's Coaching & Guidance: https://bethaweinstein.com/coaching ▶ Beth's Offerings & Courses: https://bethaweinstein.com/services▶ Instagram: @bethaweinstein ▶ FB: / bethw.nyc + bethweinsteinbiz
#438 In this podcast episode, Guy talked with Amy Elizabeth about her work as an energy channel and how she believed activations helped people reconnect with gifts already held within their soul frequency. Amy shared how psilocybin, meditation, Egypt, light language, and energy sessions had opened her to deeper dimensions, soul codes, and intuitive abilities. She explained that people's words, beliefs, and emotional stories acted like creation codes that shaped the reality they continued to experience. The conversation also explored past-life patterns, ancestral healing, timelines, blueprints, Kundalini awakening, and the importance of releasing attachment in order to come into alignment. By the end, Amy encouraged listeners to trust life more deeply, stay present, release expectations, and see every experience as something happening for their growth and awakening. ==================== Guy's Official Partners The DNA Company – Get 10% Off https://thednacompany.com/letitinpodcast FLFE – 2 Week Free Trial (No Credit Card Required) https://www.flfe.net/rp-affiliates.php?p=LiveInFlow&w=TryFLFEfree ==================== Key Points Discussed: (00:00) - Navigating Dimensions and Energetic Alignments! (01:15) - Amy's Work as a Channel for Soul-Frequency Transmissions (01:42) - What an "Activation" Actually Feels Like (02:10) - Psilocybin, Hidden Codes and Egyptian Deity Faces (03:43) - The Emerald Tablets Activation That Pushed Her to Egypt (04:31) - Clearing Distortions So Spiritual Gifts Can Come Online (06:28) - "Do You Want Your Wings Back?" — The Moment Gifts Reawaken (07:47) - The Headache Client Whose Energy Was Ready to Burst Open (09:25) - Why People Sabotage the Gifts They Secretly Want (10:00) - The Past-Life Fear Behind Speaking Her Truth (11:31) - Every Word You Speak Is a Creation Code (14:20) - Plugged Into the Simulation or Writing Your Own Story? (16:25) - Compassionate Detachment Without Taking On Someone Else's Pain (18:14) - The Timeline Tether That Snaps When an Old Story Releases (20:12) - Hidden Past-Life Attachments Behind Repeating Patterns (26:15) - LIVE IN FLOW — Experience This Work in Person (27:00) - Time-Space, Timelines and Vibrational Alignment (32:12) - The Death, Divorce and Soul Connection That Cracked Her Open (39:28) - Why More People Are Activating Into Their Soul Mission ==================== Guy's Offerings www.liveinflow.co ==================== How to Contact Natalie Namaste:www.amyelizabeth.uk ==================== Listen on Podcast Spotify Apple Podcasts ==================== Connect with Guy Instagram www.instagram.com/guyhlawrence Live In Flow www.instagram.com/live.in.flow ==================== Continue Your Journey Explore Guy's complete collection of solo podcast episodes: www.youtube.com/show/VLPLKOgPYwzskDo?sbp=Kgt1clRBdHJGem9pd0AB
In this episode of the Observatory Podcast, Scott and LaRae Wright sit down for a short, intimate conversation about prayer—not as a rule-bound ritual, but as a living practice shaped by words, intention, gratitude, and alignment. They unpack how prayer can evolve beyond fear-based asking, and why the language we use—internally and out loud—can land as either medicine or venom. If you've ever felt conflicted about prayer, spirituality, or how to “talk to the Divine,” this episode offers a grounded reframe you can actually use.Timestamps[00:00:18] Scott introduces the topic: prayer (and why this conversation may surprise you)[00:01:20] Setting the scene: a quiet Sunday afternoon, post–Valentine's Day reflections[00:04:39] Scott shares a moment from his men's group that sparked this episode[00:08:39] What prayer meant growing up: structure, habit, and fear-based “asking”[00:10:07] When prayer feels like a ritual—or a task—instead of communication[00:13:30] Reframing prayer: intention, energy, and how words shape experience[00:19:34] Gratitude as a shared frequency: how prayer can create resonance[00:20:58] Scott reads a prayer that shifted his relationship with “prayer language”[00:24:39] “Toxic positivity”: when words sound good but aren't aligned underneath[00:29:20] The line that hits: “no venom passes my lips” and why it matters[00:30:16] Venom as poison: what words can do once they're released[00:34:46] Emotional regulation, balance, and not getting stuck in heavy energy[00:39:05] Closing takeaway: your words are either venom or medicineNotable Quotes“It felt more like a ritual or maybe a task. Task that I had to do.” – Scott Wright [10:07]“Well, it creates a resonance like a song would. Those words create a resonance.” – LaRae Wright [19:48]“So no venom passes my lips and no destruction results from my speech.” – Scott Wright [21:50]“That venom is like poison. It's not retractable.” – Scott Wright [30:16]“Just everyone pay attention to your words. Pay attention to whether they are venom or medicine.” – Scott Wright [39:05]Relevant links:Subscribe to the podcast: Apple PodcastProduced by NC Productions
Most adults who smoke want to quit, and about half try to do so in any given year, yet fewer than one in ten succeed. That persistent gap between intention and outcome is one of the central challenges in public health, and it's exactly the kind of problem that calls for new thinking about how to communicate with people to support behavior change. Dr. Amanda Graham has been a leading force in doing just that in her role as chief health officer at Truth Initiative, the nation's largest non-profit public health organization dedicated to preventing addiction among young people and helping people of all ages to quit tobacco. On this episode of Raise the Line from Elsevier, Dr. Graham, who holds a PhD in clinical health psychology and has done 25 years of NIH-funded research focused on technology-based cessation interventions, helps us understand the interplay between behavioral science and digital communications in the field. "A well-timed message can really be powerful in interrupting what for many people is kind of an automatic behavior, especially via text, which data tell us is an extraordinarily powerful modality,” she explains to host Lindsey Smith. Tune-in to understand where the field is heading, and to learn about: Why "push" technology may work better than apps and websites when it comes to breaking automatic behaviors; How the rise of e-cigarettes, nicotine pouches, and heated tobacco has scrambled decades of public health messaging; How highschool smoking rates plunged from over 30% to less than 2%. Mentioned in this episode: Truth Initiative Program with Mayo Clinic If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
Psychoaktive Drogen wirken auf unser Gehirn. Die Medizin will diese Prozesse nutzen, um psychische Kankheiten zu behandeln. Ein Vortrag des Psychiaters Stefan Röpke über die aktuelle Studienlage.Stefan Röpke ist Chefarzt für Psychiatrie und Psychotherapie an den Oberberg Kliniken Berlin-Brandenburg. Außerdem ist er Traumaforscher an der Charité Berlin. Sein Vortrag heißt "Aktuelle Forschungsergebnisse: Sind Psychedelika und Cannabinoide wirksam bei der Behandlung psychischer Erkrankungen?" Gehalten hat er ihn am am 28.05.2026 im Rahmen der Ringvorlesung "Psychische Gesundheit im Fokus – zwischen Forschung, Praxis und gesellschaftlichen Herausforderungen" an der Freien Universität Berlin.+++ Deutschlandfunk Nova +++ Hörsaal +++ Deutschlandradio +++ Wissenschaft +++ Vortrag +++ Psychiatrie +++ Psychologie +++ psychische Krankheiten +++ psychische Gesundheit +++ Medizin +++ Medikament +++ Behandlung +++ psychoaktive Substanzen +++ Drogen +++ psychoaktive Drogen +++ MDMA +++ LSD +++ Psilocybin +++ Pilze +++ Ketamin +++ THC +++ Cannabis +++ DMT +++ Ayahuasca +++ Studien +++ Medikamentenstudien +++ Placeboeffekt +++ Doppelblindstudie +++ Zulassung +++**********In dieser Folge mit: Moderation: Nina Bust-Bartels Vortragender: Stefan Röpke, Psychiater, Ärztlicher Direktor der Oberberg Kliniken Berlin-Brandenburg, Traumaforscher an der Charité Berlin**********HörtippsDer Tag, ein Podcast des DeutschlandfunksHologrammatica, Science-Fiction-Thriller-Serie von Tom Hillenbrand**********Ihr hört in diesem Hörsaal:5:05 - Geschichte psychoaktiver Substanzen11:23 - Psychoaktive Substanzen in der jüngeren Geschichte19:04 - Klinische Forschung zu psychoaktiven Substanzen26:48 - Ketamin zur Behandlung psychischer Krankheiten30:53 - MDMA zur Behandlung psychischer Krankheiten33:45 - Psilocybin bei der Behandlung psychischer Krankheiten35:47 - DMT bei der Behandlung psychischer Krankheiten36:42 - LSD zur Behandlung psychischer Krankheiten38:53 - THC bei psychischen Krankheiten40:34 - Placeboeffekte42:22 - Fazit**********Mehr zum Thema bei Deutschlandfunk Nova:Ketamin: Oft als Partydroge missbraucht, wird auch gegen Depression eingesetztIllegale Partydrogen: Wie Paare versuchen, ihre Beziehung zu rettenDrogentote: Warum immer mehr junge Menschen sterben**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .
If you've ever been curious about psychedelic-assisted therapy, this episode is for you. Our very own Director of Podcasts and Digital Content, Ellice Ellis, was invited to attend Beckley Retreat's Guided Sanctuary for Black Women Psilocybin Retreat in Jamaica—a week-long experience designed to support healing through guided psilocybin sessions. Ellice chats with Dr. Joy to reflect on her experience, sharing what surprised her, what challenged her, and how the retreat has shaped her understanding of herself and her mental health. They're also joined by Hanifa Nayo Washington, lead facilitator at Beckley Retreats, who breaks down what psychedelic-assisted care actually is, why preparation and integration are just as important as the medicine itself, and how creating a culturally affirming space specifically for Black women can transform the healing experience. Resources & Announcements Want to reflect on this conversation in community? Join us inside our Patreon community where we’re unpacking this episode together. You can now catch episodes of the Therapy for Black Girls podcast on YouTube. Be sure to subscribe to get new episodes every week. Did you know you can leave us a voice note with your questions for the podcast? If you have a question you'd like some feedback on, topics you'd like to hear covered, or want to suggest movies or books for us to review, drop us a message at memo.fm/therapyforblackgirls and let us know what’s on your mind. We just might share it on the podcast. Grab your copy of Sisterhood Heals. Where to Find Our Guests Hanifa Nayo Washington Website LinkedIn Beckley Retreats Ellice Ellis Website @ellicellis on all socials Stay Connected Is there a topic you'd like covered on the podcast? Submit it at therapyforblackgirls.com/mailbox. If you're looking for a therapist in your area, check out the directory at https://www.therapyforblackgirls.com/directory. Grab your copy of our guided affirmation and other TBG Merch at therapyforblackgirls.com/shop. The hashtag for the podcast is #TBGinSession. Make sure to follow us on social media: Instagram: @therapyforblackgirls Facebook: @therapyforblackgirls Our Production Team Executive Producers: Dennison Bradford & Gabrielle Collins Director of Podcast & Digital Content: Ellice Ellis Producer: Ndeye Thioubou Production Assistant: Bria MosleySee omnystudio.com/listener for privacy information.
127. Psilocybin for Anorexia: Inside UCSF's TrialDr. Amanda Downey on UCSF's psilocybin trial for anorexia, why caregivers enroll, and what the medicine can and can't reach in eating disorders.Episode SummaryEating disorders are the deadliest psychiatric illness we have. Someone in the United States dies of one every 52 seconds, and two of every three people who get conventional treatment never fully recover. Anorexia nervosa has had no new FDA-approved treatment since the 1990s. That is the ground this conversation stands on, and it is why I sat down with Dr. Amanda Downey at Town Hall Seattle. Dr. Downey is a pediatrician and psychiatrist at UCSF and a lead investigator on an active Phase 2 trial studying psilocybin for anorexia in young adults. We talk about why her trial enrolls caregivers as participants, what psilocybin might reach that decades of treatment have not, and where the science is still honestly uncertain. This one is close to me. I recovered from anorexia myself, and I know how little the map has changed.
Broadcast from KSQD, Santa Cruz on 7-16-2026: Dr. Dawn dissects a June 2026 JAMA Internal Medicine paper that claimed simultaneous flu and COVID vaccination in veterans reduced cardiac events, arguing the retrospective natural-experiment design cannot support causal conclusions. The 20% versus 2% dropout rates between groups signal fundamentally non-comparable populations, and the divergence in cardiac events starting within a month of vaccination is clinically implausible—suggesting an X-factor other than vaccine effect is driving the numbers. Dr. Dawn delivers a pointed critique of a major chain pharmacy—part of a vertical healthcare monopoly—for creating deliberate friction around controlled-substance prescriptions through claims of stock shortages, unnecessary prior authorizations, and phantom "clarification" requests. She acknowledges the real paperwork burden of DEA compliance (quarterly reporting, six-month inspections, legitimate-need documentation) but argues chains are pushing pain patients away rather than doing due diligence, while independent pharmacies are closing at alarming rates in California. Following up on last week's Kampo medicine caller, Dr. Dawn reports research on Goshajinkigan showing it suppresses voltage-gated sodium channels at the motor end plate, functioning as a muscle relaxant used clinically in Japan for low back pain, extremity numbness, and chemotherapy- and diabetic-induced neuropathy. An emailer asks about a case report of an 80-year-old woman with 10-year Alzheimer's whose function dramatically improved after 5g oral psilocybin (Enigma strain), regaining conversation, continence, and autonomous dressing. Dr. Dawn notes plausible mechanisms (neuroplasticity, anti-inflammatory action, elevated BDNF) but cautions the diagnosis was clinical rather than confirmed with imaging or CSF markers, and recommends the emailer pursue exercise and sleep optimization for word-finding difficulties instead. An emailer asks how to reassure her chemically-hypersensitive adult son that their remediated apartment is safe. Dr. Dawn recommends commercial ERMI (Environmental Relative Moldiness Index) testing along baseboards where spores concentrate, plus urine mycotoxin testing on the parents themselves to demonstrate objectively low exposure levels. Drosophila fruit-fly males produce sperm longer than their own 2mm bodies—40 times longer than human sperm—with thousands packed inside. Fluorescent-dye imaging shows the sperm remain unusually still and coordinated, moving in synchronized slow waves like flocking birds or kelp in tides, preventing tangling. A Washington University study of 154,000 UK and 10,000 US participants used nine blood biomarkers to calculate biological age, finding people born in the 1990s show accelerated biological aging compared to those born three decades earlier. The gap between biological and chronological age correlated with increased risk of lung, colon, and uterine cancers—all rising in younger populations. A University of Pennsylvania study of 493 mouse litters found germ-free mice had shorter reproductive lifespans, more ovarian scarring, and accelerated loss of primordial follicles. Introducing gut bacteria at birth or weaning reversed these effects, as did supplementation with short-chain fatty acids alone (butyrate, isobutyrate, acetate). Dr. Dawn suggests ghee as a readily available butyrate source for those interested in the theoretical fertility-preservation benefit.
In this edition of The Random Show, Tim Ferriss and Kevin Rose reunite over tequila to talk Zen retreats, learning to rock climb at (almost) 50, mortality and grief, why you should stop saying "one day," AI predictions , and much more. Please enjoy!This episode is brought to you by:Incogni, which removes your personal data from the web, helping shield you from fraud, scams, and identity theft: Incogni.com/Tim (use code TIM at checkout and get 60% off an annual plan)Wealthfront high-yield cash account: Wealthfront.com/Tim New clients get 3.30% base APY from program banks + additional 0.75% boost for 3 months on your uninvested cash (max $150k balance). Terms and conditions apply. The Cash Account offered by Wealthfront Brokerage LLC (“WFB”) member FINRA/SIPC, not a bank. The base APY as of 1/30/26 is representative, can change, and requires no minimum. Tim Ferriss, a non-client, receives compensation from WFB for advertising and holds a non-controlling equity interest in the corporate parent of WFB, which creates a conflict of interest. Individual experiences and outcomes will differ. Instant withdrawals may be limited by your receiving firm and other factors. Investment advisory services provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, not bank-guaranteed or FDIC-insured, and may lose value.Timestamps[00:00:00] Start.[00:00:24] A tequila toast, and getting "taxed" by alcohol as you age.[00:02:18] Toaster at 15: a late-night health scare.[00:06:01] Losing Om Malik, and finding out on retreat.[00:08:03] Matt Mullenweg, Antarctica, and gratitude.[00:09:34] Coming to terms with our limited time on Earth.[00:14:37] Five days of silence and the koan "Mu."[00:15:20] Kevin's micro-insight and a plug for The Way.[00:27:25] Rock climbing after 40, and a Yosemite goal.[00:29:18] Michael Eckert and finger-strength training.[00:30:40] The Nug, Abrahangs, and a travel training kit.[00:32:57] Free Solo and climbing with a fear of heights.[00:37:53] The Blade Itself, and a friend lost in a plane crash.[00:39:19] A2 protein and Pioneer Pastures.[00:40:34] Maui Nui venison and the nitrate question.[00:43:48] deltaG ketones: what they are and the catch.[00:45:42] Ketones, dementia, and verbal fluidity.[00:46:29] Pre-grieving a parent's decline.[00:48:33] Training not to die: the one bike I can stand and the Norwegian 4×4.[00:51:10] Something beats nothing: saunas, treadmills, and Duolingo chess.[00:53:04] The MM120 anxiety study — and a small-world surprise.[00:56:17] Psilocybin, LSD, and dementia case reports.[01:01:28] Neutonic toothpicks and Kevin's AI-powered home.[01:06:12] Spooky AI personalization and investment autopsies.[01:17:38] Values cards, contractual bonds, and dark information.[01:23:25] 360 reviews and child-rearing.[01:24:54] Wispr Flow, Shokz, and my recording rig.[01:29:32] The "big three" and where AI goes next.[01:44:40] Let your winners run; buy the company, not the product.[01:51:08] Digg's relaunch, 5-Bullet Friday, and parting thoughts.*DISCLAIMER FROM TIM FERRISS: I am not an investment adviser. Nor is Kevin Rose. All opinions are mine alone. Or his. There are risks involved in placing any investment in securities or in Bitcoin or in cryptocurrencies or in anything. None of the information presented herein is intended to form the basis of any offer or recommendation or have any regard to the investment objectives, financial situation, or needs of any specific person, and that includes you, my dear listener or reader. Everything you're going to hear is for informational entertainment purposes only.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The Oregon Health Authority is considering doubling license fees for the state’s psilocybin service providers. The draft rules would also eliminate discounts for nonprofit service centers and facilitators who are veterans or qualify as low-income. A third of Oregon’s psilocybin service centers have already closed since OHA began issuing licenses in 2023. Cathy Jonas, the founder and CEO of EPIC Healing Eugene, joins us to share what the proposed changes could mean for her center. We’ll also check in with Angie Allbee, manager of the Psilocybin Services Section at OHA, about the future of Oregon’s first-in-the-nation program.
"I always remember feeling like I was part of the clean plate club," says Dr. Christle Guevarra, recalling a childhood spent quietly convinced that her weight was a matter of willpower. That belief followed her through a competitive powerlifting career and medical practice until she finally tried a GLP-1 medication herself and, as she describes it, the constant mental noise around food quieted down. Now a board-certified family and sports medicine physician, traveling team doctor for U.S. Figure Skating, and author of The Beginner's Guide to GLP-1s, Dr. Guevarra brings a rare combination of clinical authority and lived experience to the conversation around obesity medicine. In this episode of Raise the Line from Elsevier, host Lindsey Smith talks with her about what's actually changed in how physicians understand the issue and what it means for patients. "The biggest thing is reframing how we approach weight loss. It's not just a willpower problem, it is a neurobiological problem." Tune in to learn about: Why she said no to a GLP-1 prescription for two years and what finally changed her mind; The real story behind concerns about muscle loss on these medications; What happens when the “food noise" goes silent and a new set of challenges takes its place. Mentioned in this episode: Dr. Christle's website If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
We're talking about the possible end of the psilocybin industry here in Oregon and the legality around the use of AI in local political ads. Plus, we're remembering Nutmeg, the cat who was affectionately known as the mayor of Sellwood. Joining host Claudia Meza are KBOO news director Althea Billings and our very own executive producer, John Notarianni. Discussed in today's episode: Nutmeg, beloved Sellwood CVS cat known as the ‘unofficial mayor,' dies at 19 [Oregonian] Over-the-top AI campaign ads will test Oregon disclosure law [OPB] ‘I don't think the industry can survive this': Oregon regulators propose steep psilocybin fee hikes [Oregon Capitol Chronicle] Become a member of City Cast Portland today! Get all the details and sign up here. Who would you like to hear on City Cast Portland? Shoot us an email at portland@citycast.fm, or leave us a voicemail at 503-208-5448. Want more Portland news? Then make sure to sign up for our morning newsletter and be sure to follow us on Instagram. Looking to advertise on City Cast Portland? Check out our options for podcast and newsletter ads at citycast.fm/advertise. Learn more about the sponsors of this July 14th episode: SAIF Grand Central Bakery pFriem Beer
Founder of Mind Medicine Australia and inspirational speaker Tania de Jong joins the Thrive Hour for an enlightening discussion about psychedelic medicine. She explains the remarkable critical learning period that psychedelics uniquely open—a short window of heightened neuroplasticity where the brain becomes far more adaptable (or, more simply, where the brain and body are temporarily reset back to a more youthful state, allowing them to learn, heal, grow, and expand again). Scientists are now discovering that this unique window may become a powerful tool not only for expanding human potential, but also for helping the body heal from conditions such as PTSD, trauma, depression, stroke, Alzheimer's disease, Parkinson's disease, addiction, and many other neurological and mental health disorders. We also discuss why this emerging field of research could fundamentally change the way we think about healing, recovery, and human potential.See more at taniadejong.com or mindmedicineaustralia.org.au.
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What happens when traditional depression treatments stop working? Could a single psychedelic-assisted therapy session create lasting change? What does the latest research reveal about psilocybin's potential in mental healthcare? In this episode, Joe Sanok speaks with Compass Pathways CEO Kabir Nath about the emerging role of psilocybin-assisted therapy in treating treatment-resistant depression (TRD). They discuss the latest clinical research, how psychedelic therapy is being studied, and its potential to transform mental healthcare.
In this episode of The Observatory, Jake Orak joins the show to discuss his journey of self-discovery, spirituality, and what it truly means to live authentically. From his early years in drumming to life-changing experiences in Vietnam, Switzerland, Bali, and Nepal, Jake shares how travel, entrepreneurship, and personal breakdowns opened the door to deeper self-awareness and intentional living. He reflects on closing one chapter of his life through a powerful completion ceremony, the origins of his meditation and inner work, and how these threads eventually wove into his book, Threads of Change.Timestamps[02:02] Jake Orak's background in drumming[03:00] Jake's background information[06:00] Jake's experience in Vietnam and Switzerland[14:07] Jake's entrepreneurial journey[23:57] The completion ceremony that Jake did with his ex-wife[27:28] How Jake nurtured his self-awareness and intentionality[29:40] The nervous breakdown that Jake had in Bali[37:30] The genesis of meditation and personal work[47:57] How Jake's trip to Nepal influenced his life[01:08:45] Jake's connection with Utah[01:17:20] Jake's journey of writing the book: Threads of Change[01:21:28] How Jake met his partner, Adrian[01:24:57] The Inner Circle Stewards Drum Session[01:30:41] Developing your spirituality[01:35:24] The difference between living in the space of being and the space of doingNotable quotes:“When you start doing things consciously for yourself and developing your own flavor of spirituality, that's when things start to unfold, especially when you are able to share that openly within a group.” - Jake Orak [01:30:41]Relevant links: Jake Orak Instagram: https://www.instagram.com/jakeorak/?hl=enSubscribe to the podcast: Apple PodcastProduced by NC Productions
Millions of Americans were saddened and outraged by the Sandy Hook Elementary shooting in 2012 that took the lives of twenty children and six adults, and were left feeling helpless about the epidemic of gun violence in the U.S. that, sadly, continues to this day. But for our guest today, Shannon Watts, her feelings of devastation about the shooting turned to rage and fueled her unlikely rise to leading Moms Demand Action, which she grew into one of the largest grassroots organizations in the country, mobilizing millions of volunteers to push for stronger gun safety laws. “I wanted to stand shoulder to shoulder with a badass army of women because that's who gets things done in this country,” she says. In this inspiring conversation with Raise the Line host Michael Carrese, Watts pulls back the curtain on how the group achieved its successes and the philosophy of "losing forward" that kept volunteers showing up year after year. In her recent book Fired Up, Watts describes how she is bringing insights from that experience to a new mission: helping women identify their values, abilities, and desires and acting on them without waiting until everything is perfect. Tune-in to learn about: The "false fires" women mistake for passion; Why losing estrogen and testosterone in midlife might actually make women braver, not less so; The one exercise she does with every woman she coaches. Mentioned in this episode: Fired Up book Moms Demand Action If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast
TW: Suicide and Drug Use - What an episode! This episode we flashback to the 20's to attend the birth of Timothy Leary, a man who would get a doctorate in psychology and go on to become a respected psychologist before a trip to Mexico introduced him to psilocybin mushromms. We cover how psilocybin shaped and changed who he became, how he went on to be a central figure of the counterculture, his arrests, his ten year prison sentence for two, count them two marijuana roaches, how he escaped prison with the help of the Brotherhood of Love, became an international fugitive with help from the Weather Underground, how he was recaptured, finished out his sentence and then emerged and reinvented himself again and again challenging both traditional roles of psychology and spirituality as well as becoming fascinated by digital technology, virtual reality and internet culture in this man this guy was fascinating, Tune in, Turn On and Drop Out epissode of the Family Plot Podcast!Become a supporter of this podcast: https://www.spreaker.com/podcast/family-plot--4670465/support.
Fifty years ago the U.S. government classified it alongside heroin: no accepted medical use, high potential for abuse, illegal in most of the world. The peer-reviewed data now coming out of Johns Hopkins, Imperial College, and Nature tells a different story, one that has some of the most credentialled neuroscientists alive rethinking how the brain heals. In this episode, Louisa breaks down exactly what psilocybin does to your neurons, why it works where antidepressants stall for decades, and where the research is heading right now. She walks through the default mode network, the self-referential system that turns rigid and hyperactive in depression, and the 2024 Nature study that described psilocybin's effect on it as "massive" disruption. You'll hear how a single dose drove a measurable jump in dendritic spine density within 24 hours, why psilocin binds the TRKB receptor 300 times more strongly than any conventional antidepressant, and how Robin Carhart-Harris's head-to-head trial against escitalopram produced more than double the remission rate. Then she turns to addiction, where psilocybin-assisted therapy reached an 80% smoking abstinence rate at six months in the Johns Hopkins pilot, more than double the best medication available today. She covers the risks the drug-war narrative leaves out, the hard contraindications around psychosis and cardiac history, the April 2026 executive order that accelerated federal review, and why the quality of the subjective experience, measured on the Mystical Experience Questionnaire, may matter to the outcome as much as the molecule itself. You'll also hear about the desynchronization event and what fills the space when the network goes offline, BDNF and how it stacks up against high-intensity exercise, the alcohol and opioid data, HPPD, Australia's 2023 reclassification, Oregon and Colorado's state access frameworks, and why set and setting may be active ingredients in how the treatment works. Fifty years ago the U.S. government classified it alongside heroin: no accepted medical use, high potential for abuse, illegal in most of the world. The peer-reviewed data now coming out of Johns Hopkins, Imperial College, and Nature tells a different story, one that has some of the most credentialled neuroscientists alive rethinking how the brain heals. In this episode, Louisa breaks down exactly what psilocybin does to your neurons, why it works where antidepressants stall for decades, and where the research is heading right now. She walks through the default mode network, the self-referential system that turns rigid and hyperactive in depression, and the 2024 Nature study that described psilocybin's effect on it as "massive" disruption. You'll hear how a single dose drove a measurable jump in dendritic spine density within 24 hours, why psilocin binds the TRKB receptor 300 times more strongly than any conventional antidepressant, and how Robin Carhart-Harris's head-to-head trial against escitalopram produced more than double the remission rate. Then she turns to addiction, where psilocybin-assisted therapy reached an 80% smoking abstinence rate at six months in the Johns Hopkins pilot, more than double the best medication available today. She covers the risks the drug-war narrative leaves out, the hard contraindications around psychosis and cardiac history, the April 2026 executive order that accelerated federal review, and why the quality of the subjective experience, measured on the Mystical Experience Questionnaire, may matter to the outcome as much as the molecule itself. You'll also hear about the desynchronization event and what fills the space when the network goes offline, BDNF and how it stacks up against high-intensity exercise, the alcohol and opioid data, HPPD, Australia's 2023 reclassification, Oregon and Colorado's state access frameworks, and why set and setting may be active ingredients in how the treatment works. *Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: * https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ *TOPICS DISCUSSED* 00:00 Intro: A Schedule I Drug That's Making Neuroscientists Rethink the Brain 00:39 The Default Mode Network and Your Sense of Self 02:49 How Depression Locks the Brain Into a Rigid Loop 03:23 Where SSRIs Stop Short of the Problem 04:44 The Brain Imaging Data: "Massive" DMN Disruption and Reorganization 06:58 Confirming It in Drug-Naive Brains 08:04 The Rewiring: How Psilocybin Changes Neural Architecture 08:35 Dendritic Spines and Synaptic Density 09:39 How Chronic Stress Shrinks Your Neural Connections 10:16 One Dose, More Connections in 24 Hours (Neuron 2021) 11:02 BDNF, TRKB, and a Signal 300x Stronger Than Antidepressants 13:21 Psilocybin vs the Gold-Standard SSRI 14:37 Double the Remission Rate: The Numbers That Matter 15:53 Side Effects, Durability, and Treatment-Resistant Depression 16:39 The Addiction Breaker: 80% Smoking Abstinence at Six Months 17:36 Alcohol, Opioids, and the Shared Architecture of Addiction 19:10 The Dark Side: Real Risks and Hard Contraindications 22:35 The Policy Earthquake: Executive Orders and FDA Breakthrough Status 24:37 Why It Actually Works: Set, Setting, and the Mystical Experience 26:57 Bringing It All Together _______ *Thank you to our sponsors* Function Health: https://functionhealth.com/LouisaNicola Use code NEURO25 for a $25 credit BASED Bodyworks: https://basedbodyworks.com/ Use code NEURO for 20% off (plus a free toiletry bag with any set) BioOptimizers: https://www.bioptimizers.com/neuro Use code NEURO for 15% off IQBAR: Text NEURO to 64000 for 20% off all IQBAR products plus FREE shipping (Message and data rates may apply) Learn more about your ad choices. 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In this episode of the Psychedelic Medicine Podcast, Dori Lewis, MA, MEd, LPC-S returns to discuss the differences between psilocybin and ketamine. Dori is the Clinical Director of Elemental Psychedelics and Owner/Operator of Reflective Healing in Fort Collins Colorado. As a clinician, she blends transpersonal psychology, depth work, and psychedelic-assisted therapy within a model that centers the therapeutic relationship. To date, she has stewarded over 100 ketamine therapy sessions, more than 200 mushroom sessions, and numerous group ceremonies. In this conversation, Dori explores how clinicians and facilitators can thoughtfully decide when ketamine or psilocybin may be the more appropriate therapeutic option, emphasizing that the two medicines are complementary rather than competing approaches. She explains how factors such as current medications, trauma history, substance use, prior experience with altered states, therapeutic readiness, and available social support all shape this decision. Throughout the discussion, Dori argues that ketamine often serves as an accessible and effective introduction to psychedelic-assisted therapy, while psilocybin may be especially valuable for addressing grief, attachment and religious trauma, and deeper existential questions when paired with sufficient preparation, integration, and a strong therapeutic relationship. In this episode, you'll hear: Why ketamine is often recommended before psilocybin for people new to psychedelic therapy How SSRIs and other medications influence the choice between ketamine and psilocybin What personal history, symptoms, and therapeutic readiness clinicians should evaluate before recommending either medicine Which conditions and life experiences may be particularly well-suited for psilocybin-assisted therapy, including grief, attachment trauma, and existential distress How cannabis use, substance use disorders, and suicidal ideation can affect treatment planning Why community support, integration resources, and a trusting relationship with a facilitator are critical for successful psychedelic experiences The importance of cultivating self-awareness before engaging in psychedelic-assisted therapy Quotes: "How do we help somebody who is on these [SSRI] medications, has been on them for a really long time and is actually doing well with them? The answer is not to get someone to stop taking their meds just to have a psilocybin experience. That's actually really reckless, in my opinion. What I would say is, why don't we start with ketamine and see how that affects you." [7:59] "There's another important piece here: What [does the patient] want? If this person says, 'Dori, I really don't want to do ketamine. I want to work with a plant medicine. That's what I'm feeling really called to.' I might say, 'okay, then let's explore that.' But if they're open [to either], I might say, 'why don't we start with [ketamine]?'" [15:50] "There are very few cases that I would say, 'don't start with ketamine' unless somebody says 'I've already done ketamine' … or they say 'I don't want to do ketamine' but in most cases I'm going to recommend just start with ketamine" [23:05] Links: Dori on LinkedIn Elemental Psychedelics website Elemental Psychedelics on LinkedIn Reflective Healing website Reflective Healing on LinkedIn Reflective Healing on Instagram Fireside Project website Previous episode: Common Psilocybin Myths & Misconceptions with Dori Lewis, LPC Previous episode: How Psychedelics & Pharmaceuticals Can Both Aid Healing with Erica Zelfand, ND Psychedelic Medicine Association Porangui
In this episode of the Observatory Podcast, Stephen Karafiath steps into the interviewer role alongside LaRae Wright to turn the conversation toward host Scott Wright himself. What unfolds is an honest and expansive discussion about Scott's personal awakening, the evolution of his relationships, and the inner work required to live life from the inside out.Scott reflects on pivotal life experiences that reshaped how he views identity, connection, and spiritual growth. Together, they explore vulnerability, shadow work, emotional responsibility, and the courage it takes to dismantle old belief systems while building a deeper sense of authenticity. This episode offers listeners a rare look behind the microphone as Scott shares his own story — not as a teacher, but as someone continually learning, questioning, and growing.Timestamps[00:00:03] Welcome to The Observatory Podcast[00:00:18] Stephen Karafiath introduces the idea of interviewing Scott Wright[00:01:12] Why turning the lens inward feels different[00:03:40] Scott reflects on early identity and personal shifts[00:08:22] Awakening moments that changed his trajectory[00:15:06] Navigating relationships through transformation[00:21:55] Vulnerability and emotional honesty as a practice[00:29:14] Letting go of certainty and embracing curiosity[00:37:45] The cost of authenticity and redefining success[00:48:30] Shadow work and self-accountability[00:59:11] Building emotional resilience through discomfort[01:10:44] Partnership, growth, and relational evolution[01:22:05] What it means to live from the inside out[01:33:50] Integration — how Scott applies these lessons daily[01:44:12] Reflections on hosting the Observatory PodcastNotable Quotes“Sometimes the hardest thing is realizing you don't have to defend the version of yourself you used to be.” – Scott Wright [29:14]“The work isn't about becoming someone new — it's about remembering who you've always been underneath the noise.” – Scott Wright [37:45]“When we stop trying to control how others see us, that's where real freedom begins.” – Scott Wright [48:30]“You can't bypass the shadow… you have to sit with it long enough to understand what it's asking from you.” – Stephen Karafiath [59:11]“Living from the inside out means you're willing to let your life look different than you imagined.” – LaRae Wright [01:22:05]Relevant links:Earlier episode with Stephen can be found here.Subscribe to the podcast: Apple PodcastProduced by NC Productions
Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world. Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now. You'll Learn: Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE. - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range Resources: • Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:34 – Dave Rabin Introduction 05:01 – Psychedelics and Psychiatry 08:35 – Psychedelic Safety and Dosing 14:53 – Serotonin Syndrome Warning 21:17 – Vagus Nerve and Safety 27:36 – Smartphones and Chronic Stress 34:18 – Defining Trauma 38:00 – Trauma and Epigenetics 40:23 – MDMA Cortisol Gene Repair 44:44 – Therapy vs. Medicine Alone 49:15 – FDA MDMA Rejection 55:35 – Ketamine Personal Experience 59:15 – Closing and Book Recommendation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Three dark vortex beings haunt Paul Risse for three straight days, taunting him in his lucid dreams with promises of power. What starts as an exploration of consciousness becomes a supernatural battle that reshapes his entire worldview. Paul is the author of The Psychedelic Christian, and his journey runs from a TV-free childhood in Texas to consuming psychedelics close to a thousand times in a desperate search for truth. He goes off-grid with no electricity. He fasts for thirty days at a stretch. He pushes his mind further than most people ever dare. He eats mushrooms close to a thousand times. And in the end, he finds that only the name of Jesus can protect him from the entities he meets along the way.This is the conversation we could not put on the public feed. Paul sits in the basement and tackles the controversial connection between psychedelics and spirituality. He unpacks biblical pharmakeia, the Watchers, and their role in teaching humanity about root cuttings, and why he believes the modern church holds a truncated view of the supernatural. He shares powerful testimonies of healing from abuse, overcoming addiction, and the unconventional path that leads him to a deeper relationship with Christ. His story challenges traditional boundaries while staying grounded in Scripture. Want to listen to this episode and a catalog of more than 100+ other members-only episodes? How about all our main feed episodes AD FREE? Check out the vibrant community, extra episodes, and amazing perks of being a Blurry Creatures member at https://blurrycreatures.com/pages/members. Learn more about your ad choices. Visit megaphone.fm/adchoices
In loving memory of Nolan Williams (1982-2025): https://stan.md/3Qle2zp In this Huberman Lab Essentials episode, my guest is Dr. Nolan Williams, MD, a triple board-certified psychiatrist and neurologist. We discuss cutting-edge treatments for depression and post-traumatic stress disorder (PTSD), including transcranial magnetic stimulation, neuromodulation, and psychedelic-assisted therapies. We also discuss the neurobiology and therapeutic potential of specific psychedelic compounds, including psilocybin, MDMA, ibogaine, and ayahuasca. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman BetterHelp: https://betterhelp.com/huberman Timestamps (00:00:00) Nolan Williams (00:00:21) Depression (00:02:45) Heart & Mind Connection, Transcranial Magnetic Stimulation (TMS) (00:05:15) TMS for Depression (00:07:47) Sponsor: Function (00:09:24) SSRIs & Chemical imbalance, TMS, Psychedelics (00:15:24) Psilocybin, MDMA, Trauma (00:18:21) MDMA Clinical Trials & PTSD; Psilocybin & Depression (00:20:18) Sponsor: BetterHelp (00:21:38) Psilocybin, Brain Connectivity & Depression (00:23:59) Ibogaine, Empathy; Psychedelic Breakthrough & Risk (00:30:36) Ayahuasca, Behavior Change, Prisoners (00:34:46) Sponsor: AG1 (00:36:05) Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) (00:40:07) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices