Podcasts about longevity science

We welcome back Dr. Bill Andrews of Sierra Sciences to further expand on research into telomeres and telomerase for extending lifespan. Dr. Andrews explains how the existing research shows that there are potential telomere lengtheners, but they are still losing the tug-of-war with telomere shortening. He talks about how lack of funding may be the primary obstacle for telomere breakthroughs. Dr. Andrews also explains the actual link between telomerase and cancer, which is often misunderstood. They also consider the implications of gene therapy and gene editing in terms of producing telomerase. The main cause of telomere shortening is a lack of telomerase, though some things accelerate the process, like oxidative stress and inflammation. The doctors list a number of things people can do to reduce oxidative stress, including lifestyle changes and supplements that can help. Learn more about products by defytime® here. For information on IsaGenesis®/Product B, visit here. Learn more about Life Length: https://lifelength.com/ Learn more about RAADfest. On This Week on Longevity Science, Robb Taylor talks about the potential of Vitamin C to help in cancer therapy. Read more on the blog. Ask yourself: How serious am I about altering my lifestyle to protect my telomere lengths, and how much of my life, thought process and financial resources should I devote to this?  Special Guest: Dr. Bill Andrews is the President and CEO of Sierra Sciences. As a scientist, athlete and executive, he continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show and numerous documentaries on the topic of life extension, including, most recently, the movie The Immortalists in which he co-stars with Aubrey de Grey. Since 1981, Bill Andrews has focused on finding ways to extend the human lifespan and healthspan through telomere maintenance. As one of the principal discoverers of both the RNA and protein components of human telomerase, Dr. Andrews was awarded 2nd place as "National Inventor of the Year" in 1997. He earned his Ph.D. in Molecular and Population Genetics at the University of Georgia in 1981. He has served as Senior Scientist at Armos Corporation and Codon Corporation, Director of Molecular Biology at Berlex Biosciences and at Geron Corporation, and Director of Technology Development at EOS Biosciences. He is also a named inventor on over 50+ US issued patents on telomerase and author of numerous scientific research studies published in peer reviewed scientific journals. Bill is also an avid ultra-marathon runner. Born December 10, 1951, he regularly competes in 100k and 100+ mile runs often finishing at the top of his age group. These grueling races have taken him all over the world to race in some of the most extreme environments, from Death Valley to the Himalayas. His running is presently featured in the movie The High. You can order his books Bill Andrews on Telomere Basics: Curing Aging and Telomere Lengthening: Curing All Disease Including Aging and Cancer now. Follow Sierra Sciences on Facebook and Twitter: @SierraSciences.    

First and foremost, it’s crucial to envision that you’ll still be able to do athletic activities when you’re into your 80s, 90s and beyond. Dr. Gladden explains that he’s getting older chronologically, but he’s getting younger physiologically – and he speaks on his mindset that sets him up for success. The Doctor recommends getting a cardio pulmonary stress test before starting a new exercise plan, to avoid injury or catastrophic health problems like a heart attack. Another test that helps identify potential physiological problems ahead of time is the MET-TEST. They discuss different kinds of physical training, including HIIT (high intensity interval training) and the need to develop a cardio baseline by exercising at a slower heartrate over an extended period of time. The recommend spreading out the kind of workouts that you do, to spare yourself from injury and build different muscle groups. Gladden provides some other tips on preventing injury, as well as how to cope and maintain strength if you do get injured. Gladden also talks about Fortetropin®, a myostatin inhibitor that helps people build muscle by decreasing the way muscle is broken down. They talk about the benefits of “loading your frame” to improve skeletal, tendon and ligament strength, then they discuss balance training and how to incorporate it into your life. Creating a habit of doing something every day is much better for your body and mind rather than only pushing your body to its limits once or twice a week. Play is also critical when you exercise, for keeping your mind and body youthful.   In This week in Longevity Science, they discuss Klotho, what is being called “the longevity protein,” as it could one day play a vital role in helping treat potentially deadly conditions. For more information on the subject, visit https://wisdomtolive.com/longevity-protein-could-save-lives-improve-health/.   Key takeaways: Before you start an exercise plan, be safe, get tested, and work out smart to prevent injury. For your mindset, focus on being fast, agile and strong at every age. Develop the habit of exercise in small, sustaining steps. Variety in exercise is a necessity. Keep exercise fun and try new things. For this week’s empowering question, ask yourself, “How would you change your training now if you want to be engaged in your favorite activity years, or even decades, from now?”

This week’s episode focuses on the difference between what your doctor’s visit should sound like versus the few minutes the average doctor spends with a patient. Dr. Gladden explains why these short visits prevail in the current health care system, and they discuss how you need to change your mindset about who is responsible for keeping you healthy. They talk about the dangers of NSAIDs and a how most people use them. When anti-inflammatory drugs are used regularly, the root cause of the inflammation is often not addressed and is allowed to continue to cause damage. They discuss inflammation and how it leads to aging. This Week in Longevity Science also focuses on the average time a doctor spends with patients, questioning how much your healthcare provider can actually address your well-being in that short time. Dr. Gladden recommends how to get more out of your visits. For a unique perspective, Dr. Gladden goes through real results from some of Mark’s own tests after a recent visit – showing step by step how this critical set of data can be used to extend Mark’s lifespan.

Dr. Gregory Fahy is a cryobiologist and biogerontologist. He’s credited with a many of the breakthroughs in cryopreservation, and he has been working on finding new ways to use already-approved drugs. Fahy talks about his work with human growth hormone (HGH) and shares the highlights of the results of his first human trials with it. He talks about what happens around age 62-65 for most people that rapidly increases chances of death. Fahy urges people interested in longevity to pay attention to what is on the cutting edge of medicine, he stresses the importance of nicotinamide adenine dinucleotide (NAD) in staying youthful, and he believes there is a profound connection between the immune system and aging. Also on the podcast, Mark explains what he means when he says Americans are eating like we’re on death row. Dr. Gladden expands on HGH and considers some of the drawbacks and complications that could occur when it is used as treatment. In This Week in Longevity Science, they discuss peptides as a form of treatment, including how they function in the body and their promising regenerative properties. Research is being done to see how well peptides could work for highly customized medicine, not only for a specific disease but the exact disease within the individual.    Ask yourself, “How am I going to learn more about this cutting-edge science in order to change the trajectory of my aging?” About the Guest: Gregory M. Fahy, Ph.D. Dr. Fahy earned his B.S. from the University of California at Irvine in 1972 and his Ph.D. from the Medical College of Georgia in 1977 for work on basic aspects of cryobiology. He spent the next 18 years developing methods for preserving whole organs at cryogenic temperatures at the American Red Cross in Maryland. In 1980, he conceived of preserving organs by vitrification. He published the first proof of principle of this concept in Nature in 1985 using mouse embryos as a model system, an event that led to the wide use of vitrification in academic and commercial animal husbandry as well as in human assisted reproduction.   In 1995, he won the Grand Prize for Medicine from INPEX for his invention of the first effective computer-operated equipment for perfusing organs with cryoprotective agents. The same year, he left the Red Cross to become Chief Scientist of two biotechnology companies and the Head of the Tissue Cryopreservation Section of the Transfusion and Cryopreservation Research Program at the Naval Medical Research Institute in Bethesda, Maryland. In 1998, he became the Chief Scientific Officer and Vice President of 21st Century Medicine, where he invented several new principles in cryopreservation that have been extraordinarily effective in practical applications ranging from tissues to whole organs.   Dr. Fahy’s efforts have recently raised the question of whether human suspended animation might be an attainable goal that could allow the human species to survive in deep time as a result of enabling migration from the earth to other habitats in the cosmos. Dr. Fahy is a sought-after speaker and problem-solver. He is on the Board of Directors of several organizations concerned with cryopreservation or aging, serves on the Editorial Board of Rejuvenation Research, and has served as a reviewer for numerous journals and granting bodies. He has over 20 patents in fields related to cryopreservation, aging, transplantation, metabolic protection, and the reversal of autoimmunity and immunosenescence, and has many publications in the fields of cryobiology, aging, and nanotechnology. He currently serves as Director for Intervene Immune, Inc. Learn more about the projects they are working on and how to become a part of their clinical trials at http://interveneimmune.com/.

Dr. Aubrey de Grey is a biological gerontologist on a crusade to defeat aging. He thinks we are within a couple of decades of rejuvenation medicine capable of adding another 30 years to human lifespan, proposing that the first person to live to 1,000 years old may already be alive today. In the field of longevity science, there are a few roadblocks, but the biggest one is funding. They discuss why it isn’t a higher priority for average people to further this research.   Mark and Dr. de Grey cover a number of concepts at the forefront of anti-aging, such as whether increasing telomere lengths may be beneficial against aging or may cause side effects. Dr. de Grey suggests we learn more about the subject of defeating aging. Then become an advocate for the research, to bring about these medicines faster. Mark also asks Dr. de Grey about the morality of pursuing greater longevity for humans. Also on the podcast, Mark and Dr. Gladden discuss how the typical medical approach isn’t designed to promote longevity but treat the immediate problem. Medicine is still, after all, a business. Reimbursement is always going to trump research. They consider de Grey’s focus on finding a big breakthrough, versus the approach of making what you have better now, along the way. For more information on This Week in Longevity Science, visit https://news.osu.edu/news/2017/08/07/regenerative-med-study/. Dr. Gladden expands on the function of stem cells in regard to these new findings. Ask yourself, “How does it change your thinking about the structure of your family, your work, community, etc., when you consider the ability to live 120 robust years?” About the guest: Dr. de Grey is the biomedical gerontologist who researched the idea for and founded SENS Research Foundation. Learn more at http://www.sens.org/. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations.  Follow de Grey on Twitter @AubreydeGrey and Facebook: https://www.facebook.com/drdegrey/

Dan Sullivan’s Strategic Coach® program is how Mark and Dr. Gladden met, and Sullivan describes how he came to imagine a different kind of longevity than most people. He talks about how just thinking differently about the possibilities and changing his mindset about aging has helped him feel better and more capable of achieving his goal of living to 156. In Strategic Coach, Sullivan says, “Your eyes only see and your ears only hear what your brain is looking for,” which applies directly to the mindset you need to live much longer. In the reverse, he talks about the three factors he believes predispose you to die. For information on Vasper, watch this video: https://vimeo.com/159245493 For more on This Week in Longevity Science, visit the following links: http://bigthink.com/21st-century-spirituality/ketogenic-diets-promote-longevity-and-memory https://www.ucdavis.edu/news/eat-fat-live-longer/ Dr. Gladden weighs in on the ketogenic diet, offering some tips on how to approach it. However, every body works with food differently, and Gladden says that food may be the most important thing you can pay attention to for your mental and physical performance. Dr. Gladden, Mark and Robb each talk about their individual experiences with ketogenesis. Longevity requires the mind to be first, and then you bring your body along. Ask yourself, “What different questions would I be asking today if I knew it was possible to live a vibrant 120 years?” About the guest: Dan Sullivan is founder and president of The Strategic Coach Inc. A visionary, an innovator, and a gifted conceptual thinker, Dan has over 35 years’ experience as a highly regarded speaker, consultant, strategic planner and coach to entrepreneurial individuals and groups. Dan’s strong belief in and commitment to the power of the entrepreneur is evident in all areas of Strategic Coach® and its successful coaching program, which works to help entrepreneurs reach their full potential in both their business and personal lives. He is author of over 30 publications, including The Great Crossover, The 21st Century Agent, Creative Destruction and How The Best Get Better®. He is co-author of The Laws of Lifetime Growth and The Advisor Century. Dan is married to Babs Smith, his partner in business and in life. They jointly own and operate The Strategic Coach Inc., with offices in Toronto, Chicago, and the U.K. Follow Dan on Twitter @StrategicCoach and Facebook: https://www.facebook.com/StrategicCoach/ For information on his business strategies and programs, visit https://www.strategiccoach.com/

One of the biggest challenge to living longer is getting over the accepted idea that people can’t live well much longer than they do now. Just because we haven’t seen it with our own eyes does not mean it’s impossible. We must take the first step to ask the right questions rather than being confined by our own experiences. Mark talks about what some researches have concluded about a change that happened in the history of humans that may have caused a dramatic change in average lifespan. They reveal one of the most dangerous products/pollutants ever made that finds its way into our systems, discuss just how important water is and suggest what you should be drinking. They also start considering some of the many problems with the current insurance and “healthcare” systems, showing how living to 120 means you’ll be an outlier working outside of those systems.   Cancer is something that can be detected much sooner than most doctors ever test for, and Dr. Gladden talks about what helps cancer thrive that we can eliminate or reduce from our diet. They also conclude how health and aging relate to one another. For more information on This Week in Longevity Science, visit: https://www.sciencedaily.com/releases/2017/06/170621103123.htm Dr. Gladden weighs in about this news regarding olive oil and what you should and should not do with the popular ingredient. Finally, ask yourself, “What can I do to cultivate a mindset that enables me to believe I can function at a younger age?”

Living beyond 120 years doesn’t mean just flipping a switch, but it requires a slow on-ramp of changing your habits. However, this journey should start today at whatever condition your body is currently in. Diet and exercise isn’t a one-size fits-all prescription for every person, as genetics play an important role in how your body processes certain foods and responds to different physical activity. Precision is the key to real health optimization. When it comes to eating well, we need to start thinking of food as a means to support our mission of health. This doesn’t mean becoming a fanatic about food, but Dr. Gladden and Mark explain what foods should be avoided and how to choose better nutrition and establish better eating strategies. They suggest sustainable changes that you can make now to begin your path to healthy longevity. Read more about This Week in Longevity Science: http://www.independent.co.uk/life-style/health-and-families/health-news/scientists-key-to-longevity-italy-acciaroli-centenarian-mediterranean-diet-a7230956.html To learn more about 23andMe® genetic analysis: https://www.23andme.com/ See how to apply your genetic findings to your health plan at NutraHacker: https://nutrahacker.com/ Learn about the type of activity your physiology benefits from here with Athletigen: https://athletigen.com/

Where does the goal of 120 years come from? What does it really mean to live that long? Host Mark Young and longevity expert Dr. Jeffrey Gladden explain the basics of what people need to extend their health span farther than most people ever realize is possible. They consider the evidence that proves what the body is capable of and the “astronaut mindset” that we need to achieve it. Dr. Gladden explains the impact of our genes and how much you can control the fate of your own health, including focusing on the overall eco-system of your body. The current health care system is a broken one, where it only treats sick people. Dr. Gladden explains what changed his thinking about his own health and that of his patients. He started shifting his approach and learning how to improve health. Read more about this week in Longevity Science: http://www.einstein.yu.edu/news/releases/1200/maximum-human-lifespan-has-already-been-reached-einstein-researchers-conclude/ What would you do if you had an extra 40 or 50 years of lifespan?