Podcast appearances and mentions of Aubrey de Grey

Dr. Aubrey de Grey reveals why reversing aging may be easier than slowing it down in this mind-expanding conversation that challenges conventional wisdom about human longevity. The renowned biomedical gerontologist outlines his damage repair approach that's gaining mainstream scientific acceptance after initial skepticism.The financial landscape of longevity research has dramatically transformed, with billions flowing into the space. Dr. de Grey provides an insider's assessment of major players including HEvolution (Saudi-backed), Altos Labs (Bezos-funded), Calico (Google-funded) and Retro Biosciences (Sam Altman's venture), offering candid insights about which approaches show the most promise and why Google's Calico has struggled despite substantial resources.Regulatory innovation emerges as a crucial accelerator for progress. Montana's groundbreaking expansion of Right to Try legislation now allows anyone to access treatments that have passed FDA safety trials, while special economic zones like Prospera in Honduras are creating regulatory environments specifically designed for biomedical innovation. These developments could create the competitive pressure needed to modernize traditional regulatory structures worldwide.At the LEV Foundation, Dr. de Grey is conducting a thousand-mouse study combining four different damage repair interventions in middle-aged mice, aiming for a full year of life extension—far beyond the four months typically achieved. Unlike conventional approaches that rely on dietary modifications, this ambitious project incorporates advanced cell and gene therapies that target multiple forms of age-related damage simultaneously.Looking forward, Dr. de Grey offers his characteristic probabilistic prediction: a 50-50 chance of reaching "longevity escape velocity" within 12-15 years. This would enable taking 60-year-olds and rejuvenating them enough that they wouldn't be biologically 60 again for another 20 years, during which time further advances would enable additional rejuvenation cycles—potentially creating open-ended healthy lifespans for many alive today.Free sample chapter -Lies I Taught In Medical School : https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (20% off with 'LUFKIN20') https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (15% off) https://pathlongevity.com/Mimio Health (15% off with 'LUFKIN') https://mimiohealth.sjv.io/c/5810114/2745519/30611 *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmdBluesky: ...

In this in-depth conversation, Dr. Aubrey de Grey discusses his Robust Mouse Rejuvenation (RMR) studies at the LEV Foundation and why he believes we're close to achieving the crucial RMR milestone within just three years - a breakthrough that could transform aging research forever.You'll also hear about:His predictions for reaching Longevity Escape Velocity by the late 2030sWhat he would change about Bryan Johnson's longevity algorithmHow reaching RMR could trigger a global "war on aging"Why AI won't solve aging without proper experimental dataHow Demis Hassabis is the smartest person Aubrey's ever metHis involvement in designing the XPRIZE Healthspan competitionHis rebuttal to Mark Hamalainen's "replacement strategy" approachThe divide-and-conquer approach to aging and why it's superior

In this final episode of our three-part series, we welcome back Dr. Bill Andrews, world-renowned telomere scientist and founder of Sierra Sciences. If you've been captivated by the journey through telomere science so far, you won't want to miss this deep dive into the future of telomerase research and its groundbreaking potential to reverse ageing at the genetic level. In this episode, Dr. Andrews reflects on the progress made in telomere science and shares his latest insights on how telomerase activation could become a mainstream therapy for longevity and disease prevention. He also unpacks the challenges, opportunities, and what lies ahead in the quest for cellular rejuvenation. Key Discussion Points:  Telomerase Activation – Practical Applications & Next Steps What widespread telomerase activation could mean for ageing and chronic disease prevention. How telomerase therapies might revolutionise healthcare in the next decade.  New Discoveries in Telomere Research The most recent advancements and promising compounds for telomerase activation. Understanding the role of telomeres in age-related diseases and how targeting them may prevent or reverse these conditions.  Balancing Safety & Innovation Regulatory and safety considerations for bringing telomerase activators to market. How to stay informed and support the development of telomerase-based therapies.  Longevity Science & Society – What's Next? The ethical and societal implications of dramatically extending human lifespan. Addressing skepticism and dispelling myths around telomerase research. What You'll Learn in This Episode: ✅ The difference between theoretical longevity interventions and those closest to clinical application. ✅ How telomerase research aligns with other emerging fields of longevity science. ✅ Why understanding telomeres is key to unlocking better healthspan and longer life. ✅ The real-world implications of reversing cellular aging and how you can be part of the movement. About Dr. Bill Andrews: Dr. Andrews is a molecular biologist, biotech pioneer, and ultramarathon runner who has dedicated over 30 years to the study of telomeres and telomerase. He holds more than 50 U.S. patents related to telomerase activation and continues to push the boundaries of what's possible in longevity science through his work at Sierra Sciences. Dr. Andrews has been featured in Popular Science, The Today Show, and documentaries like The Immortalists,  where he co-stars with Dr. Aubrey de Grey.

In this episode of The Talk Spot, we interview Dr. Aubrey de Grey --President and CSO at LEV Foundation.   To visit Dr. Grey's work, go to https://www.levf.org/ To visit Dr. Grey's Twitter, click here https://x.com/aubreydegrey To contact Dr. Grey, contact aubrey@levf.org   The Talk Spot is an interview-centric podcast.    To visit our website: https://ucaststudios.com/ To visit other podcasts: https://podcasts.apple.com/us/podcast/u-cast-studios/id1448223064 To visit our LinkedIn: https://www.linkedin.com/company/u-cast-studios   Song: "Orion Canyon" By Insect Surfers

In this riveting second installment of our three-part series, Dr. Bill Andrews, one of the world's foremost experts in telomere science, returns to dive deeper into the groundbreaking research on telomerase activation. If you were fascinated by Part 1, this episode takes the conversation to the next level—exploring cutting-edge advancements, the latest discoveries, and what it truly means to reverse cellular aging. Dr. Andrews, founder of Sierra Sciences, has dedicated his career to decoding the mechanisms behind telomere shortening and how activating telomerase could hold the key to longevity. This episode unpacks new breakthroughs in telomerase research and the practical applications that could change the way we approach aging and disease prevention. Key Discussion Points:

In this fascinating first installment of a three-part series, we dive deep into the groundbreaking world of telomere science with Dr. Bill Andrews, a pioneering researcher in the field of ageing and longevity. Known for his revolutionary work on telomeres and their role in cellular aging, Dr. Andrews shares insights into how his research is paving the way for the ultimate goal: curing aging. Dr. Andrews, the founder of Sierra Sciences, has dedicated his life to understanding the root causes of ageing at the molecular level. This episode covers the basics of telomeres, the science behind their shortening, and why maintaining telomere length is essential for longevity and disease prevention. Key Discussion Points: What Are Telomeres? Telomeres are protective caps at the ends of chromosomes that safeguard our genetic material during cell division. As we age, telomeres shorten, leading to cellular dysfunction and ageing. Why Telomeres Matter in Aging: Telomere shortening is a major driver of ageing and age-related diseases. Dr. Andrews explains the link between telomeres and cellular senescence, inflammation, and chronic illnesses. Dr. Bill Andrews' Mission: The story behind Sierra Sciences, a biotechnology company dedicated to discovering drugs that activate the telomerase enzyme. Telomerase can rebuild and lengthen telomeres, potentially reversing cellular aging. The Science of Telomerase Activation: Current progress in identifying compounds that safely activate telomerase. Challenges and breakthroughs in the quest to develop anti-ageing therapies. Ethics and Implications of Curing Aging: Dr. Andrews discusses the societal, ethical, and philosophical implications of extending human lifespan. Addressing misconceptions about anti-ageing science. What You Will Learn: The fundamental role of telomeres in ageing and disease. How telomerase activation could revolutionise health and longevity. The current state of telomere research and its future potential. The challenges and ethical questions surrounding anti-ageing technologies. Don't miss the next episode in this series, where Dr. Andrews delves deeper into telomerase activation and the latest breakthroughs in curing aging. Subscribe to "Pushing the Limits" and share this episode with anyone passionate about health, science, and longevity! Bio: Dr. Bill Andrews is a molecular biologist, inventor, and renowned expert in the field of telomere science. He has over three decades of experience in biotech, including significant contributions to telomerase research. Dr. Andrews holds over 50 U.S. patents related to telomerase activation and has authored numerous scientific papers. Through his work at Sierra Sciences, he aims to unlock the secrets of human longevity and help people live healthier, longer lives. As a scientist, athlete, and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey.  Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, though his passion has always been ageing. In the early-to-mid 1990s, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences and Sierra Holdings. Website: https://sierrasci.com/ The Immortalists Movie: https://theimmortalists.com/watch/ Best Choice Medicine petition, that you can sign today: https://www.bestchoicemedicine.com/  

In this episode of Longevity by Design, our host Dr. Gil Blander welcomes Dr. Aubrey de Grey, a biomedical gerontologist, to explore the frontiers of aging research and lifespan extension. Dr. de Grey shares his work identifying and addressing the seven major categories of aging-related diseases. He discusses how targeted damage repair offers a promising alternative to traditional methods to slow aging, providing a path to longer, healthier lives.The conversation delves into the hallmarks of aging, their implications for medical research, and the challenges of translating results from animal models to human applications. Dr. de Grey emphasizes the importance of combining multiple interventions, such as senolytics, gene therapy, and stem cell treatments, to achieve significant gains in lifespan. He also shares insights from his work with the LEV Foundation and the Methuselah Foundation.Listeners will gain a deeper understanding of the science behind rejuvenation and the potential for humanity to reach longevity escape velocity within the coming decades. Dr. de Grey underscores the critical role of continued research, innovation, and funding in accelerating progress toward defeating aging-related diseases. Episode highlights:Introduction: 00:00:00The Seven Hallmarks of Aging: A Foundational Framework: 00:07:00Challenges in Funding Longevity Research: 00:15:00Lifestyle, Genetics, and the Limits of Current Longevity: 00:23:00The Methuselah Foundation and Early Longevity Advocacy: 00:37:00Top tip to improve healthspan: 00:52:00We Appreciate You!As a token of our gratitude, we're excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcastFor science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

An interview with Aubrey de Grey, a founding father of the longevity movement—the man who coined the phrase 'Longevity Escape Velocity.' Aubrey discusses the transformative potential of damage repair, stem cell therapies, and advancements that are turning science fiction into reality. From reversing cellular damage to extending health spans by decades, this conversation unpacks his cutting-edge research and bold predictions shaping the longevity landscape. Tune in to explore a future where living to 1000 might just be possible.

Evgeny Lebedev joins Dr Aubrey de Grey, a pioneer in biomedical gerontology - the study of life extension and rejuvenation - and co-founder of the SENS Research Foundation.Known for his radical approach to ageing, Dr de Grey discusses his latest research, society's attitude to the human lifespan and his hopes for future anti-ageing treatments. Hosted on Acast. See acast.com/privacy for more information.

Evgeny Lebedev joins Dr Aubrey de Grey, a pioneer in biomedical gerontology - the study of life extension and rejuvenation - and co-founder of the SENS Research Foundation.Known for his radical approach to ageing, Dr de Grey discusses his latest research, society's attitude to the human lifespan and his hopes for future anti-ageing treatments. Hosted on Acast. See acast.com/privacy for more information.

Evgeny Lebedev joins Dr. Aubrey de Grey, a visionary in biomedical gerontology and co-founder of the SENS Research Foundation.Known for his radical approach to ageing, Dr. de Grey discusses why some need to awaken from a "pro-ageing trance".What's Aubrey's biological age?In this episode:Why we don't “have” to ageReversing cellular agingThe ethical questions surrounding life extensionThe societal shifts we might expect if ageing becomes a treatable conditionThe science behind extending the human healthspanPlus more. Hosted on Acast. See acast.com/privacy for more information.

Welcome, to episode #94 of The Exploring Antinatalism Podcast! A podcast, showcasing the wide range of perspectives & ideas throughout Antinatalism as it exists today, through interviews with Antinatalist & non-Antinatalist thinkers & creators of all kinds - now running 5 years strong! I'm your host, Amanda Sukenick, and today, I'm speaking with co-founder of both SENS, Strategies for engineered negligible senescence, Research Foundation, as well the LEV, the Longevity Escape Velocity Foundation, and author of Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime, biomedical gerontologist – Aubrey de Grey!Watch it on YT here!: https://www.youtube.com/watch?v=WObVJ0k4x80https://en.wikipedia.org/wiki/Aubrey_de_GreyTwitter: https://twitter.com/aubreydegreyhttps://www.levf.org/https://www.sens.org/our-research/intro-to-sens-research/Author of Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime Co-author Michael Rae https://www.amazon.com/Ending-Aging-Rejuvenation-Breakthroughs-Lifetime-ebook/dp/B001ANSSKA?ref_=ast_author_dp

In this episode of the Longevity Optimization Podcast, Dr. DeGray discusses groundbreaking research in aging and longevity, focusing on combination therapies, the hallmarks of aging, and the potential of stem cell and gene therapies. He emphasizes the importance of rejuvenation over merely slowing aging and explores the role of the immune system in health. The conversation also touches on biological age testing, lifestyle factors, and the future of gene therapy in enhancing longevity. Aubrey de Grey is a British biomedical gerontologist and the founder of the SENS Research Foundation. He is a leading advocate for regenerative medicine, focusing on reversing the effects of aging by repairing cellular damage. Known for his bold vision of life extension, de Grey believes that with advanced therapies, humans could significantly extend their lifespan. He is the co-author of Ending Aging, and his work continues to shape the future of longevity science. Takeaways Combination therapies are crucial for understanding aging. Rejuvenation may be easier than slowing down aging. Stem cell therapies hold great promise for the future. The immune system plays a significant role in aging. Biological age testing can provide insights into health. Gene therapy is a promising avenue for longevity research. Lifestyle factors have limited impact on lifespan extension. Understanding the hallmarks of aging is essential for interventions. Preventative maintenance is key to longevity. The future of aging research is bright with new technologies. Chapters 00:00 Introduction to Longevity and Aging Research 02:50 Combination Therapies in Aging Research 05:57 The Hallmarks of Aging 09:12 Interventions for Rejuvenation 11:57 Stem Cell Therapies and Their Future 15:03 The Role of the Immune System in Aging 17:56 Insights on Aging and Rejuvenation 20:47 Biological Age Testing and Its Implications 24:01 The Future of Gene Therapy in Aging 26:49 Lifestyle Factors and Aging 30:04 Conclusion and Final Thoughts Learn more about Aubrey's work: https://www.levf.org Visit Kayla's website: KaylaBarnes.com

In this episode host Nils Behrens is joined by Aubrey de Grey, one of the world's leading biogerontologists, for a thought-provoking discussion on aging and the possibility of combating age-related diseases. De Grey shares his belief that aging can be treated as a disease—one that can be managed and potentially reversed. The conversation dives deep into the mechanics of aging, exploring: The seven signs of aging and how they guide medical advancements. Technological innovations like CRISPR and their potential to revolutionize aging research. The growing acceptance of anti-aging science in the scientific community. Ethical and societal challenges in the quest to extend human lifespan. De Grey offers his compelling vision of a future where people live healthy, vibrant lives, free from the burdens of aging. Key Takeaways: Aging is not an inevitable disease. The human body can be repaired like a machine. Advancements in technology are paving the way for breakthroughs in aging research. A future without age-related diseases is within reach. Tune in to this fascinating conversation and learn how modern science is shaping a healthier, longer future for us all. More about the episode at www.sunday.de/podcast About Sunday Natural Sunday Natural was born out of a deep passion and extensive research in the fields of health, healing, and personal growth. The initial motivation for founding Sunday Natural in 2013 was the lack of natural, high-quality products available on the market. Since then, the Berlin-based premium nutrition brand has remained committed to its guiding principle – creating products that follow the example of nature, are absolutely pure and free from any additives, and stand out for their exceptional quality. Today, Sunday Natural is one of the most renowned quality manufacturers in Germany, with its own research and development department in Berlin. Learn more at https://www.sunday.de.

They say aging is just a part of life, but have you ever wondered if it really has to be? What if getting older isn't just something we accept but something we could actually treat?    In this riveting episode of Peak Human Labs Podcast,  Dr. Sanjeev Goel, sits down with Dr. Aubrey de Grey, a trailblazing biomedical gerontologist and Chief Science Officer of the SENS Research Foundation. They dive deep into the revolutionary idea of treating aging as a medical condition. They explore how damage accumulates in our bodies over time and discuss the groundbreaking medical advancements that could extend our healthy lifespans. Dr. de Grey sheds light on the crucial need for investing in underfunded research and shares insights into the future of longevity science. Tune in and envision a future where health and longevity are not just aspirations but achievable realities!   Click HERE to sign in for Dublin Longevity Declaration. Key Takeaways   Aging as a medical condition versus a natural process Mechanisms of damage accumulation in the body Concept of "longevity escape velocity" Role of epigenetic changes in aging Importance of comprehensive interventions targeting different types of damage Current state of therapies for extending human lifespan Economic implications of aging therapies and preventative medicine Research on retroviruses and chronic infections in relation to aging Innovative therapies such as hyperbaric oxygen therapy and therapeutic blood exchange The significance of personalized health approaches and the microbiome's impact on longevity   In This Episode:   [00:00:00] Introduction to longevity research [00:00:51] Guest introduction [00:01:17] Personal connection [00:02:04] Dr. de Grey's background [00:03:14] Early research stages [00:04:05] Understanding aging as a machine [00:05:22] Accumulated damage mechanism [00:06:15] Comprehensive medical control [00:07:13] Categories of damage [00:07:55] Wear and tear concept [00:09:20] Epigenetic changes discussion [00:11:31] Partial reprogramming concept [00:13:30] Addressing multiple mechanisms [00:14:31] Longevity escape velocity [00:15:43] Initial pushback on longevity ideas [00:17:51] Positive outlook on aging research [00:19:51] The future of longevity research [00:20:54] Funding disparities in research [00:21:10] Business models in longevity research [00:21:58] Combining existing therapies [00:23:47] Current longevity therapies [00:24:56] Caloric restriction vs. drugs [00:25:36] Dublin Longevity Declaration [00:26:39] Community building through conferences [00:28:09] Anticipating longevity breakthroughs [00:29:12] Access to longevity therapies [00:30:58] Epigenetic clocks and age reversal [00:32:24] Retroviruses and aging [00:34:56] Persistent viral infections [00:37:24] Hyperbaric oxygen therapy [00:37:49] Therapeutic blood exchange [00:39:37] Discussion on active ingredients [00:40:41] Bone marrow transplant experimentation [00:42:09] Health benefits of bone marrow transplants [00:43:05] Personal health practices [00:43:55] Advice for maximizing healthy lifespan [00:45:01] Microbiome and longevity   Notable Quotes [00:03:14] "The idea that anyone could ever think that aging was just something we should accept has never made any sense to me at all." — Dr. Aubrey de Grey   [00:14:31] "I believe we need to get to about 20 years of postponement of the health problems of late life, which I think we might be able to achieve in the next 12 to 15 years." — Dr. Aubrey de Grey   [00:25:36] "Not only are they my favorite parts of the year, but also they are absolutely the fulcrum, the centerpiece of all of my community building effort." — Dr. Aubrey de Grey   [00:43:36] "I can eat exactly what I like and nothing ever happens, and I don't even need to do any exercise and I still stay fit, so you know, don't do as I do, do as I say." — Dr. Aubrey de Grey   [00:43:55] "Everybody's metabolism has its own strengths and weaknesses, and so honestly, the only generic advice that I feel that one can give in terms of maximizing one's healthy lifespan is to pay close attention to your body." — Dr. Aubrey de Grey   [00:44:28] "I honestly can see a strong argument for just recommending to absolutely everybody that they should eat gluten-free food for like a fortnight, just to see whether they feel different." — Dr. Aubrey de Grey Our Guest   Dr. Aubrey de Grey is a biomedical gerontologist and founder of the LEV Foundation, focused on repairing aging-related cellular damage. Based in Silicon Valley, he earned his BA in computer science and Ph.D. in biology from the University of Cambridge. His research targets the characterization and repair of aging damage. A Fellow of the Gerontological Society of America and the American Aging Association, he advises numerous journals and organizations and is a sought-after speaker at scientific and public events. Resources and Links Peak Human Labs https://www.youtube.com/@peakhumanlabs/videos https://www.peakhuman.ca/ https://www.instagram.com/peakhumanlabs/?hl=en https://open.spotify.com/show/5hx9R37ElxgzCrBccRWoHd?si=8atK0n82QbeL3DWg5-vjvg&nd=1&dlsi=ce0f77aa4f304724   Dr. Sanjeev Goel https://www.linkedin.com/in/sanjeevgoelmd/?originalSubdomain=ca   Dr Aubrey de Grey https://www.levf.org/ https://www.linkedin.com/in/aubrey-de-grey-24260b/ https://web.facebook.com/aubrey.degrey/?_rdc=1&_rdr

Dr. Peter Lidsky posits that aging is not merely a process of accumulating damages, as commonly believed, but rather a programmed adaptation akin to a part of the immune system. His hypothesis suggests that aging evolved to eliminate older individuals who might be susceptible to severe chronic diseases. Check out these other great views as well:Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4Interview with George Church: https://youtu.be/yNplpykf0B4Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OMInterview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05QInterview with Nir Barzilai : https://youtu.be/LuOAShcjOt0Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8 About the showThe Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. Learning with lowell linksYoutube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips:https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com/ Peter Lidsky linkshttps://twitter.com/LidskyPeterhttps://www.linkedin.com/in/peter-lidsky-71997540 Timestamps00:00 Start00:10 who is Peter Lidsky / research / longevity01:30 Academia differences04:20 Aging explained and the Squirrel test07:20 Pathogen control hypothesis15:50 Lifespans different organisms (fanq)17:55 Natural experiments to prove/disprove (fanq)24:30 Implications of Theory of aging25:00 Senescent cells31:32 Therapeutics / interventions from his research33:00 Implications of his theory37:50 Limits of aging40:10 What do people need to see to believe his theory44:30 Show him the drug that is better than rapamycin46:40 Data sharing / organization to push forward48:50 What is slowing aging research49:50 Pleiotropic genes / aging52:00 Research at Hong Kong52:40 Focus of future research53:55 Devices for research56:00 Bryan Johnson Blueprint59:20 People to follow01:00:00 place to stay up to date01:01:30 Thanks for all the fish longevity #aging #agingresearch

Kim takes you to the next level of health and performance without the standard prescription of hours of cardio or chicken and broccoli.With laser focus on what has been proven to work for improved performance, sleep, cognitive function, metabolic health and stress levels, you will get maximum results with minimum effort. Work smarter, not harder to make your body look and perform the way you intend it to.The Fabulous in 15 approach is a minimalist protocol that takes you from stressed and tired to vibrant and energetic in the shortest possible amount of time. Check out these other great views as well:Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4Interview with George Church: https://youtu.be/yNplpykf0B4Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OMInterview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05QInterview with Nir Barzilai : https://youtu.be/LuOAShcjOt0Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8. PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com Kim rahir linkshttps://kimrahir.com/https://www.linkedin.com/in/kim-rahir/?originalSubdomain=eshttps://www.instagram.com/kim.rahir/?hl=en Timestamps / chapters00:00 Start00:05 Kim Rahir00:50 Accomplishments after MS diagnosis / Olympic weight lifting02:04 Olympic weight lifting03:00 Deadlift04:30 Powerlifting07:55 Mike Tyson, Adversity and training10:10 Rejuvenating after training13:00 Getting through lack of motivations / 5 minute rule16:55 Only 5 minutes19:15 Lifelong learning24:20 Wheelchair to power lifting29:40 MS32:55 202434:55 Dream number36:55 Meditation / mindfulness39:00 Learn mediation / headspace41:45 Strength training43:40 Weeks until getting better45:55 Train to failure48:00 Health and energy focused49:30 Time intensity52:40 Diet / food!54:55 Family dinners and not over eating57:55 Celebrities / interesting meals01:01:45 Community01:05:10 Saying what you want01:08:55 how to get family on board01:11:30 Women vs men advantages and disadvantages01:13:10 Adversity01:14:30 Self Advocacy / MS diagnosis01:22:00 Post having kids01:23:55 One thing you can do right now01:24:55 Her Clients01:25:40 Thank you for all the fish weightlifting #multiplesclerosis #olympicweightlifting

“My long-term goal is to model the pathways involved in human aging in order to develop therapeutic interventions. I organize an annual aging conference in the Midwestern United States with the dual goal of promoting the aging as an adaptation theory and promoting the aging as a disease mindset. The conference website is curing-aging.com.” Check out these other great views as well:Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4Interview with George Church: https://youtu.be/yNplpykf0B4Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OMInterview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05QInterview with Nir Barzilai : https://youtu.be/LuOAShcjOt0Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8. PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com David Katz linkshttps://www.linkedin.com/in/davidwarrenkatz/https://www.youtube.com/watch?v=zhbOo_INMwg&t=65s&ab_channel=CuringAginghttps://www.curing-aging.com/ Timestamps00:00 start00:20 Programed aging hypothesis explained01:20 Michael Levin / bioelectricity02:15 Telomerase / concerns around copies of copies04:15 Ability for immortality in animals04:44 Immortal jellyfish06:02 Butterfly brains06:40 Programmed aging in practice for therapies07:16 FDA aging as a disease08:33 Curing aging objectionable09:15 We need to work against our bodies10:18 Fasting / Michael Rae / Caloric restriction11:55 Highly against Richard Dawkins selfish gene and ideas around evolution13:20 Start of slides13:50 Why do we age / David's argument18:20 Different types of aging23:20 Induce damage to test hypothesis25:10 David St Clair work26:20 Evolution has consistently selected for aging29:20 Aging and cancer30:00 exponential population growth31:00 Evolution as an ecological thing32:00 Animals getting bigger and smaller on small island / evolution as multivariable equation35:11 Mole Rats and rats36:25 people who get castrated live longer37:22 Bryan Johnson / interfering with body38:00 Testosterone / women live longer39:22 Mechanism of the body working against itself40:15 Easy interventions / keeping track of time for puberty, death, etc44:30 Squirrels having a year long internal clock46:00 Uniform life events / aging clock / evidence that convinces people50:50 ATF4 Pathway / muscle mass52:00 Not even trying to make therapies ATF454:40 Developing therapies against the body55:30 VCs at conference56:10 Exploring this hypothesis58:40 Tricking body to “think” it's younger59:10 Aubrey De Grey like hallmarks of aging clock1:00:00 Epigenetic clocks / biologic clocks01:01:30 Disrupting dreams / sleep01:02:50 Sleep affecting aging01:04:08 People who stop sleeping die within a number of weeks01:04:40 Does the biological clock have state and turning it back01:10:20 Steel man argument against the Programed aging hypothesis01:10:55 A good case for the clock / time of day, year, and stage of year01:13:00 Dolphins and sleep01:13:30 Target therapy with this theory01:15:40 Children's hospital01:16:05 Kids better able to fight off cancer / medicine divided01:17:11 PhD Tensor decomposition presentation / fundamental relationship of matrices01:18:40 implications and pushback for the tensor decomposition01:19:30 What are the trade offs / stop measuring algorithms based off complexity01:21:18 Real life example / chromosomes01:24:30 SENS and the human genome li...

In this episode of the Smarter Not Harder Podcast, Dr. Aubrey de Grey discusses the latest advancements in anti-aging technologies, including senolytics, telomerase, parabiosis, and regulatory progress. Join us as we delve into: + The definition of aging and its processes according to Dr. Aubrey de Grey. + Recent developments in rejuvenation technologies and global regulatory changes. + Practical advice and the role of individuals in the fight against aging. This episode is for you if: - You're fascinated by breakthroughs in aging and healthspan extension. - You want to hear from Dr. Aubrey de Grey, a leading expert in the field of longevity, about the latest in age reversal science. - You're curious how new technologies like synolytics, parabiosis, and telomerase are evolving. - You seek insights on bridging the gap between metabolism and better health. You can also find this episode on… YouTube: https://youtu.be/Eahkiv8_OCU Find out more about Dr. Aubrey de Grey:Longevity Escape Velocity (LEV) Foundation: https://www.levf.org/LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/ Twitter: https://x.com/aubreydegrey Learn more about Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Get 10% Off your purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Boycott OpenAI, published by PeterMcCluskey on June 18, 2024 on LessWrong. I have canceled my OpenAI subscription in protest over OpenAI's lack of ethics. In particular, I object to: threats to confiscate departing employees' equity unless those employees signed a life-long non-disparagement contract Sam Altman's pattern of lying about important topics I'm trying to hold AI companies to higher standards than I use for typical companies, due to the risk that AI companies will exert unusual power. A boycott of OpenAI subscriptions seems unlikely to gain enough attention to meaningfully influence OpenAI. Where I hope to make a difference is by discouraging competent researchers from joining OpenAI unless they clearly reform (e.g. by firing Altman). A few good researchers choosing not to work at OpenAI could make the difference between OpenAI being the leader in AI 5 years from now versus being, say, a distant 3rd place. A year ago, I thought that OpenAI equity would be a great investment, but that I had no hope of buying any. But the value of equity is heavily dependent on trust that a company will treat equity holders fairly. The legal system helps somewhat with that, but it can be expensive to rely on the legal system. OpenAI's equity is nonstandard in ways that should create some unusual uncertainty. Potential employees ought to question whether there's much connection between OpenAI's future profits and what equity holders will get. How does OpenAI's behavior compare to other leading AI companies? I'm unsure whether Elon Musk's xAI deserves a boycott, partly because I'm unsure whether it's a serious company. Musk has a history of breaking contracts that bears some similarity to OpenAI's attitude. Musk also bears some responsibility for SpaceX requiring non-disparagement agreements. Google has shown some signs of being evil. As far as I can tell, DeepMind has been relatively ethical. I've heard clear praise of Demis Hassabis's character from Aubrey de Grey, who knew Hassabis back in the 1990s. Probably parts of Google ought to be boycotted, but I encourage good researchers to work at DeepMind. Anthropic seems to be a good deal more ethical than OpenAI. I feel comfortable paying them for a subscription to Claude Opus. My evidence concerning their ethics is too weak to say more than that. P.S. Some of the better sources to start with for evidence against Sam Altman / OpenAI: a lengthy Zvi post about one week's worth of evidence Leopold Aschenbrenner Geoffrey Irving But if you're thinking of working at OpenAI, please look at more than just those sources. Thanks for listening. To help us out with The Nonlinear Library or to learn more, please visit nonlinear.org

Our topic in this episode is progress with ending aging. Our guest is the person who literally wrote the book on that subject, namely the book, “Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime”. He is Aubrey de Grey, who describes himself in his Twitter biography as “spearheading the global crusade to defeat aging”.In pursuit of that objective, Aubrey co-founded the Methuselah Foundation in 2003, the SENS Research Foundation in 2009, and the LEV Foundation, that is the Longevity Escape Velocity Foundation, in 2022, where he serves as President and Chief Science Officer.Full disclosure: David also has a role on the executive management team of LEV Foundation, but for this recording he was wearing his hat as co-host of the London Futurists Podcast.The conversation opens with this question: "When people are asked about ending aging, they often say the idea sounds nice, but they see no evidence for any actual progress toward ending aging in humans. They say that they've heard talk about that subject for years, or even decades, but wonder when all that talk is going to result in people actually living significantly longer. How do you respond?"Selected follow-ups:Aubrey de Grey on X (Twitter)The book Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our LifetimeThe Longevity Escape Velocity (LEV) FoundationThe SENS paradigm for ending aging , contrasted with the "Hallmarks of Aging" - a 2023 article in Rejuvenation ResearchProgress reports from the current RMR projectThe plan for RMR 2The RAID (Rodent Aging Interventions Database) analysis that guided the design of RMR 1 and 2Longevity Summit Dublin (LSD): 13-16 June 2024Unblocking the Brain's Drains to Fight Alzheimer's - Doug Ethell of Leucadia Therapeutics at LSD 2023 (explains the possible role of the cribriform plate)Targeting Telomeres to Clear Cancer – Vlad Vitoc of MAIA Biotechnology at LSD 2023How to Run a Lifespan Study of 1,000 Mice - Danique Wortel of Ichor Life Sciences at LSD 2023XPrize HealthspanThe Dublin Longevity Declaration ("DLD")Music: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration

In this thought-provoking episode of The More Freedom Foundation, hosts Rob and Ruairi embark on an exploration of the elusive quest for immortality. Rob's desire to live forever sparks a conversation that spans the fascinating landscape of longevity research. Longevity Escape Velocity (LEV): Inspired by the visionary (or crank?) Aubrey de Grey, the concept of LEV tantalizes us—a point where, for every year we survive, we gain an extra year. But is it achievable, or merely a dream? The Tired Pursuit of Eternal Youth: The field of anti-aging has seen its share of promises and setbacks. From resveratrol to rapamycin, researchers have explored various avenues. Yet, the elusive fountain of youth remains elusive. Join us as we delve into the science, ethics, and hopes surrounding longevity. Can we truly escape the clutches of time, or is aging an inevitable part of the human experience? Tune in for a captivating discussion that transcends mortality itself. ⁠⁠⁠Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Books⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok

In this weeks episode we catch up with Dr Bill Andrews who happens not only to be a top age level ultra marathon athlete who has competed in literally hundreds of ultramarathons in his life time including some of the absolute toughest like the Badwater Ultramarathon and La Ultra - The High, two that I know well, but he is also a world leading longevity scientist who focuses his research mostly on telomeres and extending life span and health span. Telomeres are found at the tips of our chromosomes and have been shown, in thousands of scientific peer-reviewed studies, to be the clock of aging in humans. When telomeres get shorter, we get older, and our health declines. Dr Bill says that while telomeres may not be the single cure for ageing, we can't cure ageing without fixing the telomere shortening problem.  Telomere attrition (shortening) is one of the known hallmarks of aging and Dr Bill shares in this insightful interview how we can: slow or even reverse ageing through the lengthening of our telomeres: how he discovered the worlds most powerful telomerase inducing substances. what we can expect in the near future and how we can harness this knowledge today what we can do from a lifestyle perspective to slow the shortening of our telomeres why lengthening telomere protects you from cancer rather than causing cancer as has been rumored in the past. what the longevity and anti-aging field doing today and how he believes that the many breakthroughs are already here or coming very soon. he elaborates on his life long mission to cure ageing and what he does personally to at age 72 to prevent the normal declines (hint - he still running 100 milers and going for an age group record in the next year or two. If you want to delay disease, decline and decrepitude then this is the podcast for you! As a scientist, athlete, and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey. See www.theimmortalists.com/watch. Bill is known for being a scientist first, focusing on scientific research, allowing others, instead, to market the products that his company discovers. Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences and Sierra Holdings. You can see what Dr. Bill is up to at www.sierrasci.com Dr. Bill is the author of "Curing Aging" and "Telomere Lengthening"  BIO Dr. Bill Andrews is the Founder and CEO of Sierra Sciences and Sierra Holdings, a companies are focused on finding ways to extend human lifespan and health span through telomere maintenance. Telomeres are found at the tips of our chromosomes and have been shown, in thousands of scientific  peer-reviewed studies, to be the clock of aging in humans. When telomeres get shorter, we get older, and our health declines. As a scientist, athlete, and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey. See www.theimmortalists.com/watch. Bill is known for being a scientist first, focusing on scientific research, allowing others, instead, to market the products that his company discovers. Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, though his passion has always been aging. In the early-to-mid 1990s, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences and Sierra Holdings. website: https://sierrasci.com/ The Immortalists Movie:  https://theimmortalists.com/watch/ Best Choice Medicine petition, that you can sign  today: https://www.bestchoicemedicine.com/   Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.  To pushing the limits, Lisa and team

Unlock the mysteries of aging and longevity with the visionary Dr. Aubrey de Grey in our latest podcast episode. His pioneering work in biomedical gerontology offers a roadmap to not just slowing down the aging process, but potentially reversing it. As Dr. de Grey transitions from his origins in computer science, he deciphers our biological clock, revealing how funding from venture capitalists and the crypto-community is accelerating the quest for extended human healthspan.Immerse yourself in the conversation with Dr. de Grey as we dissect the STEMs approach to aging—a revolutionary concept that treats the body as a machine in need of periodic maintenance. By delving into the seven types of cellular and molecular damage, we explore the possibility of not just preserving our youth but restoring it. Dr. de Grey's insights into age-related tissue damage and the advantages of an engineering approach in developing therapies provide a fresh viewpoint on how we might extend our golden years with vitality.As we draw inspiration from robust mouse rejuvenation studies, the episode paints an optimistic picture of the future for human treatments. Dr. de Grey illustrates the forefront of longevity research, shedding light on the promising therapies that could redefine aging within our lifetimes. Tune in for an episode that not only educates but empowers you with practical advice to take charge of your own longevity journey, respecting the uniqueness of your body's metabolic needs. Join us as we navigate the landscape of a longer, healthier life with one of the most forward-thinking minds in gerontology.Please support this podcast by checking out our sponsor (20% off with this link):https://prolonlife.com/Lufkin*** CONNECT WITH ROB ON SOCIAL MEDIA ( ~250k)*** Web: https://robertlufkinmd.com/X(Twitter): https://twitter.com/robertlufkinmdYoutube: https://www.youtube.com/RobertLufkinMDInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Threads: https://www.threads.net/@robertlufkinmdFacebook: https://www.facebook.com/robertlufkinmd *** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us for your health industry product or service, please contact us at: https://www.robertlufkinmd.com/contact/ NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice ...

In today's episode of Welcome To Cloudlandia, I share the story of my unexpected adventure travelling to Buenos Aires for a pioneering knee stem cell treatment. I describe how my blood and fat cells were transformed into new cartilage and transported across continents for the procedure. I also recount my partner Babs' experience treating an inflamed toe and the vitality we've regained. Our discussion explores the pursuit of longevity and regenerative medicine's potential to make 156-year lifespans attainable through the normalization of audacious goals. We delve into hopes for abundant years energized by purpose and new ventures. Additionally, I discuss the art of self-talk and strategies like daily focus tasks negotiated through self-management.   SHOW HIGHLIGHTS Dan shares his transformative experience with stem cell treatment in Buenos Aires, describing the process of turning his own cells into cartilage. We discuss the broader implications of regenerative medicine and how it might extend our lifespans and rejuvenate our vitality. The episode touches on the concept of setting ambitious longevity goals, like living to 156 years, to guide life's endeavors and encourage significant projects. Dean talks about the importance of mental self-management and compares it to a daily negotiation to focus on critical tasks. We delve into the balance between productive 'focus days' and the freedom of 'buffer days', and how each contributes to overall productivity and creativity. The conversation includes insights on the internal quest for happiness and whether the 'fountain of youth' might be a state of mind. Dean and I examine the concept of 'Dean Landia', a metaphor for the mental environment we create and have control over. We discuss the entrepreneurial mindset, emphasizing the role of deadlines, and the Danger, Opportunity, and Strength (DOS) and Money, Labor, and Time (MLT) frameworks for success. The episode reflects on how personal goals influence our actions and the normalization of extraordinary ambitions to build confidence. Dean describes his experience with stem cell treatment for his knee injury and his partner Babs' treatment for an inflamed toe, highlighting the physical and psychological benefits they've experienced post-treatment. Links: WelcomeToCloudlandia.com StrategicCoach.com DeanJackson.com ListingAgentLifestyle.com TRANSCRIPT (AI transcript provided as supporting material and may contain errors) Dean: I wouldn't have it any other way. Welcome, Mr Claude Ladiak. Mr. Dan: Jackson. Mr Jackson, yeah Well, very pleasant woman who, and you know, I was the first one on today and she said you're the first one to Join the call, the others will join pretty soon and so far, in about seven years, only one person has shown up. So I want to know who the? Others are. Is this the National Security Agency? Is this the Communist Party of China? I'm just trying to get a handle of who the others are. Dean: I think you're probably right once, two or more Gathered that everybody is. Dan: Yeah, but I found that just the two of us is more than enough. That's the truth. Dean: Well, I am excited to hear about all of your Adventures here You've been. You've been all over the world. Here seems like you've been in Chicago. You've been in most exciting Lee Buena Flores. Yes, I'm excited to hear all about the Adventure here. Dan: Yeah Well, spire Chicago goes. I missed the bullets, so that's all I can report on we're not. We're not in the part of the city that's in the crossfire zone, but anyway yeah. Buenos Aires was interesting. It's only the second time I've been to South America, and the first time was just to land in Ecuador, co City in Ecuador, and then we took a flight to the Galapagos Islands and this was as the guest of Richard Rossi, who put together, you know, a gathering that went to the Galapagos Islands and you know the plain lands and one of the islands, and then you take a National Geographic boat and I think it's Linblad and National Geographic and then you know we investigated all the sea life and the animal life which are, you know, very distinct from what's found elsewhere, and that was great, but it was mostly just painting out, with a whole bunch of people that were interesting to talk to. So that's only the first time and that was a long time ago. And then we just do Create the setting here. The context, again, as a result of being a guest of Richard Rossi, has a mastermind group which is called Da Vinci 50, and Babs and I took us two or three years to get our schedule right so that we could Guarantee our attendance at all the different meetings, but the very first one, this was in New Orleans. This was last January. I met a doctor, babs. I met a doctor there from Buenos Aires by the name of Gustavo Mabilia, and, and he told a story about what he's doing with stem cells and these are your own stem cells, white blood cells and fat cells that if you collect them and then send them. It's not an entirely easy process to get them to Argentina, but we got them there and he would then convert them into the stelle, the stem cells that you're having problem with your and your body and I have an orthopedic injury in 1975. I tore my cartilage in the left knee and in those days they would Take out the torn cartilage. They wouldn't do that today, but that's you know, that was the best that was going 48 years ago. And he said oh, we can regrow your cartilage. She said we can the part that was snipped out. We can regrow that cartilage and I said that's cool. That's cool. Yeah, I was convinced that Babs has a chronically inflamed right toe that really impedes a lot of her walking or exercise and it's inflamed bones. So I didn't know that bones got inflamed. It shows up on MRIs when you do an MRI. So long story short, through dr Hasi, who's our main Medical guide and explorer for us in Nashville, tennessee. He's got a clinic there called Maxwell Clinic. He did all the, you know the coordination before us to. You know, make sure that our stem cells were there, make sure that the they turn it into a magic potion I don't know too much more about it and he arranged with for our trip down. So we went. This is so. Yesterday was Saturday, we're talking on Sundays, it was two. Two Saturdays ago we took an overnight flight to Buenos Aires, where it's now springtime because they're in the other hemisphere. Yeah, it's more complicated than I'm telling you, but that's the upshot of it for the week and and so, as far as the you know, the brain cells and the vascular cells, the only thing I can say and I have to be, I think I have to be cautious here, but because I have, like a lot of entrepreneurs do, I have the ability to create my own placebo's. Dean: Right. Dan: Yeah, okay so all. I can say I've come back after the trip and we had. We came back after seven days and and this week I have felt more energized and more confident. Dean: Then I can remember recently sounds like quite an adventure and the upside yeah, gonna be. The upside is gonna be a total new development of cartilage in your knee specifically. Second, what's the Hope for it Like? Are you gonna have the knees of a preteen Swedish boy, or are you gonna Just have the normal knees of 79? Dan: well, basically yeah, I'll basically have the, basically the knee I had before the injury. Okay so that's 48 years, so six months, and the orthopedic is pretty easy for them. I mean, they're doing some advanced work and other parts of the body, but the cartilage is, you know, it's pretty, it's not a complicated thing, right? But what happens is they take my blood cells and my fat cells and they turn, essentially turn it into new cartilage cells and that's. You know, that's what stem cells are that? How? Dean: does it gather. Dan: Yeah, well it's. This was all done in Nashville and. So, what they do is they? You know it's, it's basically a centrifuge and you have an IV in both arms and the blood that gets taken out and it's, and they take the white blood cells out and then you know it's simultaneously they're taking blood out now return it to your body, but they're taking the white blood cells, which is far prior less of your blood than your red blood cells. Okay, actually it was like a two hour, two hour session and it was like a cup full. You know, after a big cup, a big mug full, and so that's the white blood cells and then the fat cells. You go to a plastic surgeon Because they're used to taking you know it's part of plastic surgery of taking out fat cells and so and you get enough they're, they're told how much of each are required for them to basically do a year's worth of. You know we're going to go down probably four times during the next 12 months, starting with the first trip two weeks ago. And they'll have enough just from that one extraction, extraction of both, they'll have enough. So next time I go down I broke both my Achilles tendons in the 1970s. That was a bad decade. That my in 1970s were just a really bad decade anyway. So anyway, and the Structurally, I mean they're shortened because of the surgery, the tendons, are shorter, but they've developed calcification. Oh yeah which reduces flexibility, and it's got pain attached to it. So next time they'll Take my same fat cells and white blood cells and they'll turn it into something that gets rid of all the Calcification and my and my tendons. Yeah, so, and that will give me more push-off, it'll give me more flexibility to go along with the new cartilage. So I think probably, you know, probably I'll be gaining back about 30 or 40 years of Running ability out of my legs, you know. Dean: I always Run for his money yeah. Dan: Well, yeah, I just want to run again. I enjoy running and I haven't been and it's been too painful to do for the last 10 years. And then the whole thing is the overall, the Direct injection. You're just going after a particular issue, but the IV, the, it goes into your brain and it looks for anywhere where your brain cells Are not performing correctly and it wakes them up. So the stem cells don't cure anything, they just wake up the natural cells that are there and they start growing again. And the same thing with the Vax vascular system. That's your, but I. I would say that Knowing that now I have the means to repair anything in my body as soon as it's identified as a problem is Very confidence. Dean: It's very confidence building you know it's very and. Dan: I was noticing that I had sort of blot into Sort of why I know I'm wearing down and I know that there's an end to it at some point, but I hadn't realized how much that was until I got the other thought that, no, almost anything that's going wrong with you you can repair now and you can rejuvenate it, and so that's a. That's a huge confidence builder. Dean: Yeah, and it's really I mean perfectly timely, right as you're entering into, you know, in my ninth decade. Yeah, exactly entering into your ninth decade with the goal of it being the best decade ever which I love that framework, by the way and at a time when normally it would be, you know, physical deterioration happening, you're like physical rejuvenation. Dan: You're going backwards on that thing, yeah, I mean yeah, you know the there's so many factors that are involved in aging, and some of it is just the fact that your cells only reproduce 50 times. Okay, there's a thing which is called the Haflick barrier. This is a I don't know quite what kind of scientists he was, but he found that every cell in the body and there's 20, I think, 26,000 different types of cells in the body, some number like that they all reproduce only 50 times, as far as they can tell, but they don't do it equally. They don't, they don't. They're not doing it at the same time. Heart muscles might be faster, other cells are slower, but it sort of reaches the limit of everything by the time you're 120. We only have one person on record where there's actual valid records of birth who has lived 120. She also lived, she also. She got to 122. She died. A French woman who died about 10 years ago. Dean: And that's the only person that. Dan: I mean, there's all these claims, you know, you know around the world, the people who lived at 200 and 300 and everything else, but they don't have any valid records which actually established that. So anyway, but but most people don't get to 120. Dean: Right, exactly. Dan: Yeah, I mean, even if you only got to 120,. I said, even if you only got to 120,. I said well yeah, I mean, if you're an entrepreneur and you're at top of your game at 60, and you're saying, no, I guess I have to retire pretty soon. Well, the decision to retire is sort of telling your body it doesn't matter how long the body lasts now I mean, it can go really quickly. But if I know I'll be 18 next May and if I know that I can stay in top form for another 25 or 30 years at the top of my game right now, then that's a big deal. Dean: Yeah, I look at, I saw me. You know, bob Barker died earlier this year at 99. And the thing that was going around with that, he got to as close to 100 as he could without going over the big showcase showdown. Kind of close to 100. Dan: But you know George Burns, the comedian, very famous mid-century 20th century, you know, 40s through the 80s or 90s. He had a goal that he was going to do a full show at the Palladium in London, big Venue in London, england, and he did it. And then and I always gave him as an example because he was performing full time in his 90s and then- did an actual 100th birthday. And then he was in a shower about four weeks later, he slept, broke his hip and he died two weeks later. And I said, George, you didn't understand what you did. You should have set another date for when you were 110. Exactly. Dean: Isn't that amazing, I wonder? Yeah, I mean, that's kind of a. You've been programming yourself for 156 for as long as I've known you Since 1987, you know since 19, 36 years right now, yeah. Yeah. So that's kind of you know. You're just approaching or just at the halfway mark there ramping up, gaining speed, gaining momentum. Dan: Well, people say do you really think you're going to live to 156? And I said I know I won't if I don't have it as a goal. Amen. Dean: Well. Danny just setting yourself up for disappointment. Dan: Well not me everybody who ends up with my messes after I'm gone. You know when I'm gone. What do I care? Dean: Exactly, that's the point. I love that. Dan: I love, I laugh. Dean: I tell people that all the time, when you said the just for you, it's just going to be live, live, that's better. There, you go, you're not going to experience the disappointment. Dan: There's a great French philosopher from the 1600s named Blaise Pascal. Dean: And there's a blaze. Dan: There's a Pascal wager. And he says you know, when you think about it, all of us regarding if there's anything after this life, it's a guess. You know it's a guess and it's a bet and he says but let's just take a look at the two bets. There's nothing after you die. Okay. Dean: Okay well that's cool. Dan: The other one is there's a whole other world after I die. And he says it's not so much which makes the best sense after you die. It's what bet makes the sense right now? Because if you think that there is a whole world afterwards and it turns out there's nothing, well you really haven't lost anything, because you know there's nothing, but what? If you believe your whole life there isn't anything after death, and then you find out that there and they said you know, and you said geez, if only I had. Oh my God, if I had known this and he's believing there's a afterlife is a much better bet, psychologically and emotionally, for right now. Yeah, yeah so I'm kind of a. I'm a kind of a Pascal wager kind of guy. Mm, hmm, that, I mean, is so back then everybody you know lived a life that took the natural course. You know I mean living to 60 and 70 in those days was kind of an achievement, with all the different ways you could die back then disease and you know and violence unless you were, unless you were, matthew's a lot. Yeah, yeah, but birth records. Dean: No documentation. Dan: I'm sorry, Matthew's a lot. I'm sorry, but where's your come on? Where's your papers? That's everybody. Dean: Every time I think about muscle, I think about our Aubrey, aubrey de Grey. Yeah and the Missusola prize. Have you heard any updates on that? I've kind of lost the past. No, I saw video. Dan: I saw a video of him talking and I got a feeling that that Living living two or three times more than natural, but not being happy right now is probably Not a good bet, because I didn't get the sense that he was a happy. I didn't get the sense that he was a happy person, you know. So I mean you never know, I mean people who never saw aren't necessarily unhappy, and people who smile all the time aren't necessarily happy, you know. Dean: I mean happiness. Dan: Yeah, an internal disc, it's an internal disposition, yeah. But anyway, you know I'm just reporting back. I'm sort of a bit of a trailblazer in relationship to this stuff, but I'm only. I will tell you, dean, I was thinking about this when I was in Buenos Aires that if I didn't have that goal of living to 156, I wouldn't be doing this stuff right now. Dean: Yeah, that's true, right, you're already in traditionally if you speak about like. I'm beyond refund right now. You know, I mean, you're out of warranty. Right now You're an extra innings Actuarial tables. You're an actual outlier. Dan: Yeah, but I'm really a profit center for the insurance companies. It's just been me paying them, just been me paying them up until now. I love it. Dean: Dan is so great. I think this is like that's one of the great things of you know being alive at this time in particular, just all the access to these things. That's only gonna get better, as we understand. I remember when I went to the first, the first abundance 360 and Richard Rossi's friend, gary Kaplan, was there with us. I think you've met Dr Kaplan. Dan: Oh no, Gary. Yeah, Gary, you know, I see him every, I see him at every defense. She 50 maybe. Dean: You know, he's a great guy Okay yeah. Yeah, I really went to the go out there. Dan: I went to the go out because silence with Gary, so we had a lot of time to talk. Dean: So I've known him for a long time, you know, well, I remember when this was. This had to be Almost 10 years ago, right 9, 9 years ago. Anyway, the first abundance 360, not the very first one, the first one in LA Beverly Hills Hotel there, and you know I'm sitting with him and he was Saying you know, when you look at all the medical advancements that are coming right now, this is back then you said it's gonna. It's gonna seem like we've been Throwing rocks at people to get them healthy, you know, compared to what's actually coming. I mean, yeah, we would describe what you know regenerative, and that's a good word. That's kind of become, you know, newly minted. Regenerative medicine is All the things from the on a cellular level regenerative Regeneration, replacement. You know we're pretty much going to be able to replace everything Before we repair it or repair it. Yeah, replace repair, regenerate right. Dan: And that's pretty cool. So, yeah, I like well, I think, the hmm, I got involved with Peter Diamandas in I'm just trying to think. There was December of 2011, the first before a 360 meeting. We didn't have a name for it, but this was in Silicon Valley and and one of the things that sort of connected Peter and Peter and me Was really the fact that we both had this commitment to living way beyond normal age, you know. But I had a thinking process, you know. Of course it's the first hour of strategic coach, which is the lifetime extender. And he came in at that time and I said you know it's not a goal you can achieve unless you can normalize it as a normal thought. I said you know our brain, and Our brain really resists abnormal thoughts. We, it has to be normal. So I set myself the goal in 1987 that every time I thought of my lifetime I would just think 156, you know, you know, at that time, life expectancy for males you know of my background and you know the thing was 78, so 156 is twice and so it took me about three years before it was just a normal thought. So whenever I you know I'm pushing 80 now and you know, and I said, well, what's my lifetime, I said 156. So at 80. That makes me very ambitious because I know I've got in my own mind, I've got, a way you know, enormous amounts of time left, really twice a lifetime 76 years. Yeah, yeah, I got 76, 76 years to get things done, so it makes me Totally confident about starting new, big, new big things. And I mean your whole life is either happy or unhappy. Unhappy based on the kinds of conversations you're having with yourself. I agree. Dean: I agree a hundred percent. I mean, you realize, I was realizing, I've been thinking a lot about this. You know, this straddling of the mainland and the cloud land via, and those thoughts then brought me into the actual game, which is game land is where at all happened and I realized that how much of you know Dean landia is affected by the inputs and circumstances and the Context and relationships and conversations and environments that you voluntarily Put yourself in, you know, surrounding yourself with the environment that's going to shanty people yeah, people, I mean. Dan: Yeah. Dean: And. Dan: I just had a thought, and that was triggered by your Dean Landia, that I only have direct access to one human being on the planet. You know, and same goes for you, and a lot of people spend their life. A lot of people spend their life trying not to be, not to deal with the one person they have direct access to you know they're hoping they're going to be saved from the proof that they hope something else will save them from the person that they're actually inside of, and you know so. so my, my whole point is why don't you just take ownership for the, the relationship that you have just with this one person, and you know there's new dimension, there's new dimensions presenting themselves all the time. And and the other insight I had and that comes from our conversations, because we're we've got a very similar approach to life on a lot of different fronts and I was thinking, you know, I've been trying to control my brain up until I think, about two years ago. I was going to control my brain and, you know, make sure my brain was focused on this and that. And I said why don't we change the relationship here and take for granted that you want, I have no control over my brain. And the other thing is why don't we just see where it goes every day? Because it's totally unpredictable. I spent one day and just sort of locked in where my brain was going that day and there was absolutely no predictability to what's forever. And I said, okay, why don't we just I'm just going to do it deal with my brain wherever it goes? During that day I wanted to do three useful things for my plans. You can go anywhere you want, but by the end of the day, I want progress on this, I want progress on that, I want progress on that, okay just have fun, you know, do whatever you want, but by the end of the day, if you and I are going to sleep happily tonight, you know, I got to see progress on these three things. Dean: Oh, my goodness, Dan, that's so funny. You know, it's like I've been having these exact conversations with myself here. It's like taking over the management. You know, it's all in that vein of you know, imagine if you applied yourself your FELF, these things of taking over the management, you just you hit it on the head that I only have direct control over one human on the planet and that's me. And I thought about entering and I realized that my brain, my desires, my ambition, my you know vision, the visionary in my brain here is not necessarily the one in control of the, the doing part of my brain, the labor management versus labor right. And so I was thinking about I heard one time that there's a form of contract where a you know production will enter into a contract with an actor or a celebrity, that with their company on an SSO contract which is for services of. So it would be enter, as I thought it's kind of like entering into a contract with my brain here for services of being Jackson and thinking what you just said is like those. If I could just like allocate time and attention to you know I've I've thought a lot about your thing of three, three things a day. How much I'd love to hear from you how, on a buffer day when you are I don't know how you define whether buffer day or focus you've got workshop focus days where those are like the Bob's fled run kind of thing. That you know what's happening on a workshop day. You get up and I'm sure your car arrives at a certain time and you get taken to the workshop and everything is for my computer, or my computer does, because some of them are virtual. Yes, exactly Okay. And then but on the days where I never struggle with those, I realized that everything that I do get done has that external exoskeleton or that scaffolding to make sure that gets done. If you're just in the right, all you have to do is, you know, get in the car and the rest of it is taking place, or open up the computer and sit down and you're. You know you're able to focus and deliver the workshops. But I'm curious about your free range time, where I think I may have, like I crave and do a lot to carve out big blocks of uninterrupted time, only to end up having nothing to show for it. Because, I don't get myself to sit down and do the things that I've carved out all this time to do. I'm curious how, what your experience is on getting Dan to do stuff that requires his own batteries, I guess I'd love to hear your experience. Dan: Here again, I think we're very similar and I think that's why our podcasts are so enjoyable, because to a certain extent, neither of us wants it to end when we get going. But I have one of our models in the strategic coach is a theater model which is front stage, back stage, and front stage is really, whether you have a viable company or not, it's your front stage your profitable front stage impact is what determines whether you're getting paid to take care of everything else, and I don't have to be motivated for a front stage impact. You know, and workshops is an example, podcasts is another example, creating new thinking tools is another example, and writing books is another example, or videos or audios. So these are all front stage. In other words, if I can get this done, then it has a multiplier impact out in the world on other people, and that either me directly interacting with the world, or our coaches or our team members interacting with the world, and that ends up in profitability. Okay, so those are my focus days, but some of the days that are not focused days, I have to be preparing for those days. Okay, but anytime. I think of front stage impact preferably. I don't need to be motivated to do that, I love doing that. Dean: Okay. Dan: And that's my usefulness to myself, that's my usefulness to everybody I engage with. But just going back to my decision over the last two years of just letting my mind wander, when I'm not directly engaged in front stage impact activities, my brain can do anything at once. It can go anywhere and so I don't really care. Before I used to care. I'm not making use of my front stage, my back time, I'm not making it. I said leave it alone, just let it go where it wants to go, let it run, let it go out and frolic, let it explore and everything else they really run. So I mean, it took me till practically age 78 to come to this agreement with my brain, and so I'm either in hyper focus, actually doing the things that make money and spread the reputation and do all sorts of good things, or it's free reign. I really don't care. Dean: And to me what it does. Dan: It frees me up from the tyranny of time and effort. That you're absolutely maximizing the use of your time. I said I don't care about my time and I don't care about my effort, as long as I make a front stage a profitable front stage impact. If it takes me an hour to do that, and it's an hour if it takes me a full day workshop, then it's a full day workshop, but I don't really care about the time and the effort, I just really care about the impact. And then backstage. I just say brain, go and do whatever you want to do, think about anything you want to think about, and I couldn't care less. You don't have to justify your existence. My brain doesn't have to justify its existence when it's not on stage. Dean: That's very interesting when you're creating a new tool. For instance, you introduced a tool on Friday for our pre-melt connection. Call yeah, your melt tool, and what's happening? How does that come about? What's your process? Dan: for that. Dean: That's one of the key outputs that you're providing is new IP and thinking tools for the thing, so how does that come about? If your mind goes, you mentioned you've read Peter Zion's book seven times now. Dan: Yeah, the end of the world is just the beginning. I think it's the most important book in the world. I'm reading and I read it seven times. So it's Peter Zion. Dean: Z-E-I-H-A-N. Dan: And the book is called. Dean: The. Dan: End of the World is Just Beginning and he's written. This is the fourth book that he's written since 2014, where he's just predicting that everything we were expecting to happen 10 years ago ain't going to happen that way, and a whole new world is going to happen. Dean: And he's got very plausible readings. Dan: I'm not going to explain the book here but it has a profound impact on me. But it seemed to me that he was operating at a macro geopolitical level and I said well, is there a simple sort of set of gauges, if you will underneath, that determines in any place at any time whether things are moving forward or they're stagnating or they're falling behind? And I came up, it just sort of fell out of. He doesn't talk about this directly, but after I'd read it a whole number of times, it just struck me that it was the cost of four things that determine this, and one of them was the cost of money. How much is it cost you to get money? And that comes in two forms how much is it cost you to get a loan and how much is it cost you to get an investment? Those are the two main, the financial vehicles that underlay growth. And then your profitability is the third one. Are you keeping a lot of what you're making? Dean: That's savings. Dan: And then the cost of energy and all of its different forms and the cost of labor getting really top notch. You have access to other people's skills, and how much is it cost you to do that? And then the cost of transportation, because we live in a physical world and to move a pound costs money including your own pounds and that costs energy and I just started playing with this. I know we did. I was mentioned on a previous one of our podcasts Mike Kenix, we did it on that and everybody I talked about it. It had a simplifying effect on their thinking. I said this is a good tool. That's all I do If you come up with an acronym and it's. M-e-l-t. And I said I think we're going into a great meltdown next 30 years where everything of those four factors is going to cost more, and you can see it. Yeah, I mean you can see it. All you have to do is read the news every day. Most of this is going up, energy is costing more, labor is costing more and transportation is costing more. And I said so. You know, I think it's a neat way. So what I did is I just introduced a tool to the free zone entrepreneurs, just two days ago, when you were there and I said if this is true, let's just suppose that it's true, that these costs are going to go up for everyone else and what's your biggest advantage and opportunity over the next 30 years? And that's just. That would be a thinking tool, and it has two qualities it's a sudden new thought, it provokes your interest, but it brings your right back to what you, as an entrepreneur, can take advantage of. So those are my criteria for a new thinking tool for a strategic coach. It took me from the time the thought occurred me to Friday, because that's the first time I did it. It took me six months of playing around with the idea, checking with other people you know conversation and then just looking at the news and saying, is the news going in the direction of the theory? You know? Dean: Yeah, and then. So when you like to get it to that tool, state that's part of your when you're letting your mind wander. It's so funny, dan, I've been talking about this idea of the self-milking cow, the idea of embracing your bovinity and realizing that you're the one that can create the milk. And if you set up an environment like I've moved towards, is that we basically have things divided into three divisions. I call it the pastures, which is me out roaming the pastures, you know, exploring and being a happy cow. And then we have got a milking shed and the milking shed is set up for me to come in and be, milked, essentially to turn my thoughts, free range thoughts, into, you know, into digital milk, meaning that we're recording something about my you know I'm doing it either through a podcast or through a Zoom or interview or whatever we've got with my team. And then we have the processing plant, where they take the digital milk and they process it into podcast, courses, tools, anything like that. So I'm curious, like it sounds like one of your pasture roaming activities is reading things like the like Peter Zion's book and your six you know your of daily input from real clear politics and the Wall Street Journal and All the things that you do. You put those all in and then ruminate on them and and then outcomes the things. When you're turning it into a tool, though, are you consciously like? Are you starting with, like illustration, journaling, doodling? What's your, what's your kind of creation process for? Dan: yeah, I do, because our tools come in in One page written. There's boxes and the box. You know the number of boxes, the kind of boxes you have so with with the melt tool. All I did was have it's called your great meltdown and your great meltdown DOS. Okay, so DOS is a previous tool that we have in coach is that and any human activity. There people are responding to dangers that they're fearing loss of some sort. The other thing is opportunities, where they're excited about the possible gain of something. Dean: And then their strength. Dan: These are the things that they already have going for them. And I said I think all human beings, every day, operate within a unique DOS framework of things that are fearful about, things are excited about and things that they're confident about. So what I did is I did a matrix and matrixes are cool, so the cool way of structuring where you have MLT, money, energy, labor, t and then I had four arrows going up for, I think, cost, and then down the side I had danger, opportunity, strength. And then I said to the entrepreneurs, because they're familiar with the DOS, everybody At the level that you're at in coach, the free zone. This is an old tool. This is, you know, 20 years old and some of you have been there 20 years and I said so from your standpoint that all of your clients and potential clients, customers, are going to have the danger of rising melt costs. What's your opportunity in this? Okay. So what's there the opportunity with dangers? What's the opportunity? Yeah. What's your opportunity with other people's opportunities? And what's your Opportunity with other people's strengths? And then you go through it and there's another exercise which I won't go into right here, and you come back and then you just have a general conversation, you have breakout sessions and conversation, and the room goes crazy, you know, and because everybody's done thinking about their thinking, they've talked about their thinking, and they come back and they hear everybody else's thinking and that's what produces the workshop. But the thing that triggers all this motion is that I have deadlines to create new things. Dean: Yes, I got it and that's really how it all comes out and that's, I think, do you have a sense of what your, how much of your time? Is that free range versus you know the structured workshops? And so I guess it's getting left, or more and more Free range. Dan: Well, I would say even on my most intense front stage days. Still, the majority of the day is free range and then when I don't have that type of thing. It's all free range, yeah, but it's not a. Yeah, without a commitment to someone else to deliver something, giving myself deadlines is worthless. Yeah, me too. Dean: I've discovered that about me giving myself a backstage free range deadline. Dan: Well, first of all, I think free range and deadline is a contradiction in terms. Right. Dean: Yeah, this is what I like about the, you know is doing a workshop or scheduling a milking session. Is I know that if I've got a milking session Scheduled, like I've been going to the studio? Yeah you know, on Thursday morning, 10 o'clock to 12 o'clock, and I know that you know I'm prepared for For being milked at that at those times, you know. So I'm either, yeah, doing something myself. Some of the best things that I've done have been just preparing myself to record a State of the Union or a new, you know, record myself as a thought. I do find those a little more that I have to. You know, if I have to have that time set aside, right, that's how I've been. How I did the convert more leads book was I Could free range, I get my thoughts together for this section of the book and then I go and talk that out. So it gives me that structure. One thing that I have realized and that's been very helpful is this idea that Reality you know, the mainland, the real world here, applying yourself, moves at the speed of reality, which is 60 minutes per hour. And, yeah, if I'm going to embark on a project that's going to take 20 hours, that there's no possible way to allocate or Put in those 20 hours without actually putting in the 20 hours and that I can't do it. All at once. So the only thing I've got an infinite. I've got an infinite Opportunity list of all of the things that I could possibly do, but what I've been experimenting with that's very helpful is Just loading in my next 10 hours. What if I? What can I do in the next 10? 50 minute focus sessions that I have? you know that's really that narrow. That helps me prioritize and make a decision, which is the first step of you know my acronym of playing golf a goal, optimal environment, limited distractions, six time frames. So a goal is the decision of what am I going to do at Tuesday from 10 o'clock to 12 o'clock I've got two potential hours that I can allocate there and what am I going to do in those times. You know, that's really been a big help. Dan: Yeah, yeah and. I, you know and I've got a reputation that goes back, certainly the full extent of the Coach program, which goes back. I mean we'll be 35 years Next November. We're in our 35th year of the coach program. Dan always delivers. Yeah, and I have a Absolute commitment to never in any way undermining that reputation. So whatever it takes, dan always delivers, okay me too. And you know if you handle that, whatever it takes to deliver, you know life gets real, simple. Dean: Yeah even though it's sometimes. You've seen that illustration of the you know assignment made, accepted, deadline here the timeline, and then the little five percent at the very end and the 95% all allocated is goofing off. And then five percent, all the work done, while crying. Dan: No matter what. Dean: Yeah, well done, you know, yeah, yeah yeah, because your, your entire reputation is just in terms of commitment, is that you've made to other people? Yeah, and I think, though, our ability to our ability to always deliver, I think has really been, you know, honed because of our, the requirement of us always pulling a rabbit out of our hats growing up. Dan: I think yeah, even in any assignments or anything like that. Dean: We've gotten Really good at improv theater you know, yeah, I. Dan: Well, I think the other thing is if that's true, you always deliver then, what people can't see about that? Are you happy with the time you spend that other people can't see? And I would say that I'm up about 1,000 times over the last 30 years. I'm really happy with the free range time. I'm really happy with all the work backstage that I have to do. I used to be grueling. It was working nights, it was working weekends under severe pressure, and that's not true anymore, because I've got a sense of the framework of the project. I got the sense of the timing of the project. And I said you know and then you know, I've kind of worked out what the deal is with my brain. My brain always delivers at the end of the day. And I says, well, there's two of us that always deliver my brain. If I set my brain three things by the end of the day, have this self, I don't care what you do, You're not accountable for any of your time, but by the end of the day I want these three things delivered. And then I've got my commitments to deliver a front stage. So I've just worked out a two-way deal here. I love it. Dean: That's great. Well, Dan, I never yeah. Dan: I think we're kind of cosmic soulmates, you know, both the payoff and the problem. I think we're. Both of us have tried similar landscape in terms of coming to grips with ourselves. I agree. Yeah, I find these conversations infinitely interesting One takeaway that you got from today, and I'll tell you mine. Dean: So that's my big takeaway for today. It's given myself permission to just roam the pastures, to enjoy my free range, as long as I just hold up my end of the bargain right. That was a night. I got a lot out of that. Dan: Yeah, and I think that I do really interesting podcasts also with Shannon Waller which is called Inside Strategic Coach and people always want to know. Our clients especially want to know how we do, what we do backstage. And I'll just drop this as a topic for her, because I think this the greatest tension that entrepreneurs have is not front stage, but the greatest tension is backstage. Dean: Yeah, yeah, I agree, I agree. Well, I'm excited about next week. Yeah, I want to talk again even more conversation. I look forward to it. Thanks, steve, this is really great, thanks. Dan: Steve, okay, I'll talk to you next time.

Esta es una de las distopías más tratadas en cine y series de ficción. Incluso yo la he tratado alguna vez anteriormente con otro punto de vista, desde el punto de vista de la ciencia. Hoy, vamos a abordar el tema madurado desde un punto de vista filosófico para tratar esta distopía de lo que podría implicar vivir para siempre. ¿Es posible vivir para siempre? La idea de vivir para siempre ha fascinado a la humanidad desde tiempos inmemoriales. ¿Quién no querría disfrutar de la vida sin tener que preocuparse por el envejecimiento, las enfermedades y la muerte? Sin embargo, ¿es realmente posible alcanzar la inmortalidad? ¿Qué implicaciones tendría para la sociedad, la ética y el medio ambiente? En este artículo, exploraremos algunas de las posibles formas de vivir para siempre y sus ventajas y desventajas. La inmortalidad biológica Una forma de vivir para siempre sería lograr la inmortalidad biológica, es decir, detener o revertir el proceso de envejecimiento celular. Algunos organismos, como las medusas Turritopsis dohrnii o las hidras, son capaces de regenerar sus tejidos y evitar el deterioro asociado a la edad. ¿Podría la ciencia aplicar este mecanismo a los seres humanos? Algunos científicos creen que sí, y están investigando diferentes estrategias para lograrlo. Por ejemplo, el biogerontólogo Aubrey de Grey propone una serie de intervenciones terapéuticas para reparar el daño molecular y celular que se acumula con el tiempo. Estas intervenciones incluyen la eliminación de las células senescentes, que dejan de dividirse y secretan sustancias inflamatorias; la restauración de la longitud de los telómeros, que son las estructuras que protegen los extremos de los cromosomas; la prevención de la glicación, que es la reacción química que altera las proteínas; y la eliminación de las mutaciones en el ADN mitocondrial, que afectan a la producción de energía celular. Otra posible vía para alcanzar la inmortalidad biológica sería la manipulación genética. Algunos genes están relacionados con la longevidad, como el gen FOXO3, que regula el estrés oxidativo, la inflamación y el metabolismo. Al modificar estos genes, se podría aumentar la esperanza de vida y la salud de los individuos. De hecho, se ha demostrado que ciertas variantes genéticas están asociadas con una mayor probabilidad de vivir más de 100 años. La inmortalidad biológica tendría algunas ventajas, como la posibilidad de disfrutar de una vida más larga y saludable, sin sufrir las enfermedades y el deterioro físico y mental que conlleva el envejecimiento. Además, se podría aprovechar la experiencia y el conocimiento de las personas mayores, que podrían seguir contribuyendo a la sociedad de forma activa. Sin embargo, también tendría algunos inconvenientes, como el riesgo de sobrepoblación, la escasez de recursos, el aumento de las desigualdades, la pérdida de la diversidad genética y el aburrimiento existencial. Además, la inmortalidad biológica no garantizaría la protección frente a otras causas de muerte, como los accidentes, la violencia o las catástrofes naturales. La inmortalidad digital Otra forma de vivir para siempre sería lograr la inmortalidad digital, es decir, trasladar la conciencia humana a un soporte informático. Esto implicaría crear una copia digital del cerebro, con todos sus recuerdos, personalidad y emociones, y alojarla en un servidor, una nube o un robot. De esta manera, se podría preservar la identidad y la continuidad de la persona más allá de la muerte física. Algunos científicos y empresas están trabajando en esta dirección, utilizando técnicas como la neuroimagen, la inteligencia artificial y la realidad virtual. Por ejemplo, el proyecto BrainEx pretende crear un mapa detallado de la estructura y la actividad del cerebro humano, utilizando escáneres de alta resolución y algoritmos de aprendizaje automático. El objetivo es poder reconstruir el cerebro en un formato digital y simular su funcionamiento. Otro ejemplo es el proyecto Nectome, que ofrece la posibilidad de preservar el cerebro mediante un proceso de vitrificación, que consiste en inyectar un líquido que evita la formación de cristales de hielo y mantiene intactas las conexiones neuronales. El propósito es poder escanear el cerebro en el futuro y extraer la información que contiene. La inmortalidad digital tendría algunas ventajas, como la posibilidad de escapar de las limitaciones del cuerpo físico, explorar nuevos entornos virtuales, interactuar con otras mentes digitales y acceder a una gran cantidad de información y conocimiento. Además, se podría elegir el aspecto, la edad y las características de la representación digital, así como modificarla según las preferencias o las necesidades. Sin embargo, también tendría algunos inconvenientes, como la pérdida de la conexión con el mundo real, la dependencia de la tecnología, la vulnerabilidad a los ataques informáticos, la falta de privacidad y la incertidumbre sobre la autenticidad y la singularidad de la conciencia digital. Además, la inmortalidad digital plantearía cuestiones éticas, legales y sociales, como el derecho a la vida, la propiedad intelectual, la responsabilidad moral y la dignidad humana. Conclusión En conclusión, vivir para siempre es un sueño que ha inspirado a muchas generaciones, pero que también plantea muchos desafíos y dilemas. La ciencia y la tecnología están avanzando hacia la posibilidad de alcanzar la inmortalidad, ya sea biológica o digital, pero aún quedan muchos obstáculos y riesgos que superar. Además, la inmortalidad no es solo una cuestión técnica, sino también filosófica y existencial. ¿Qué sentido tendría la vida si no tuviera fin? ¿Qué valor tendría el tiempo si fuera infinito? ¿Qué implicaría la inmortalidad para la identidad, la libertad y la felicidad humanas? Estas son algunas de las preguntas que deberíamos hacernos antes de aspirar a vivir para siempre. Puedes leer más y comentar en mi web, en el enlace directo: https://luisbermejo.com/este-podcast-te-cambiara-la-vida-zz-podcast-05x17/ Puedes encontrarme y comentar o enviar tu mensaje o preguntar en: WhatsApp: +34 613031122 Paypal: https://paypal.me/Bermejo Bizum: +34613031122 Web: https://luisbermejo.com Facebook: https://www.facebook.com/ZZPodcast/ X (twitters): https://x.com/LuisBermejo y https://x.com/zz_podcast Instagrams: https://www.instagram.com/luisbermejo/ y https://www.instagram.com/zz_podcast/ Canal Telegram: https://t.me/ZZ_Podcast Canal WhatsApp: https://whatsapp.com/channel/0029Va89ttE6buMPHIIure1H Grupo Signal: https://signal.group/#CjQKIHTVyCK430A0dRu_O55cdjRQzmE1qIk36tCdsHHXgYveEhCuPeJhP3PoAqEpKurq_mAc Grupo Whatsapp: https://chat.whatsapp.com/FQadHkgRn00BzSbZzhNviThttps://chat.whatsapp.com/BNHYlv0p0XX7K4YOrOLei0

Amazon-Inhaber Jeff Bezos, Google-Gründer Sergej Brin – sie alle investieren jetzt in Milliarden Dollar Projekte, die ein großes Ziel haben: das menschliche Leben zu verlängern und Alterungsprozesse, die wir immer als selbstverständlich hingenommen haben, außer Kraft zu setzen. US-Tec-Milliardär Bryan Johnson hält den Tod inzwischen nur noch für ein technisches Problem, das wir lösen können. Und der britische Bio-Gerontologe Dr. Aubrey de Grey will den Tod gleich ganz abschaffen, in dem er menschliche Zellen ab einem Alter von 60 Jahren so sehr verjüngt, dass sie nur noch 30 Jahre alt sind. Ist das wirklich möglich? Können Ärzte das Altern stoppen? Darüber habe ich in Zürich mit Dr. Dr. Anna Erat gesprochen, Medizinische Direktorin des Longevity Centers Schweiz, einem der weltweit führenden Institute für die Erforschung eines langen und gesunden Lebens. Ihrer Welt-Karriere: In Finnland geboren. Harvard Medical School. Erste female Medical Direktorin der Schweizer Hirslanden Klinken. Während Covid wird sie Medical Director des legendären Weltwirtschaftsforums in Davos. Heute ist sie die Koryphäe des Longevity Centers in Zürich, behandelt Formel 1 Fahrer, Hockey-Nationalspieler, Ironman-Triathleten und Top-Manager. Longevity leitet sich aus dem lateinischen ab. „Longus“ – zu deutsch lang. Und „Vita“: das Leben. Mittlerweile ein 90 Milliarden Dollar Business. Es geht darum, nicht nur die Lebensspanne zu verlängern, sondern vor allem die Gesundheitsspanne. Denn unsere Lebenserwartung hat sich seit dem 19. Jahrhundert zwar verdoppelt. Im Schnitt werden Frauen heute 83,4 Jahre alt. Männer 78,5 Jahre. Aber laut Weltgesundheitsorganisation WHO sind wir nur 71 von 82 Jahren wirklich gesund. „Langlebigkeit ist nur erstrebenswert, wenn sie das Jungsein verlängert – nicht aber das Altsein hinauszieht“, sagt Nobelpreisträger Alexis Carrel. Die entscheidende Frage also: Wie können wir alle ganz lange und ganz gesund leben. Die neuesten Erkenntnisse, die Chancen und Risiken und warum sich unser biologisches Alter immer mehr abgrenzen lässt von unserem numerischen Alter – das alles jetzt hier in TOMorrow. Also checken wir ein und lassen uns mehr tolle Lebenszeit verschreiben: Viel Spaß bei der Chefarzt-Visite, viel Spaß mit Dr. Dr. Anna Erat.

The second part of my conversation with George Chanos. He discusses the incredible advances in healthcare and the potential for humans to live longer than ever before. He shares insights from Aubrey de Grey of the SENS Research Foundation, who believes that the first person to live to a thousand years old is alive today. While the specific numbers and timelines are up for debate, George emphasizes that the important thing is that these advancements are coming in our lifetime and will have significant global implications. Get ready for a future of ever-shifting global relations and technological warfare.[00:00:26] Advances in healthcare.[00:05:11] Reversing aging and genetic code change.[00:07:32] Surviving the technological tsunami.[00:11:21] Implications of spatial web.[00:16:07] TikTok as a news source.[00:19:36] Future wars and warfare.[00:25:33] Ukraine's NATO membership debate.[00:28:00] Insect drones in urban areas.[00:31:27] Unlearning and relearning.

Dr. Kelsey Moody is a process-oriented biotechnology executive who has specialized in the study of aging and aging mechanisms for over a decade. Since 2013, He has successfully built Ichor from a living room start-up into a premier, vertically integrated contract research organization that focuses on pre-clinical research services for aging pathways. Proceeds from this work are used to self-fund R&D initiatives that constitute Ichor's portfolio companies in enzyme therapy (Lysoclear, Inc.), small molecule drug discovery (Antoxerene, Inc.), and protein engineering (RecombiPure, Inc.). Kelsey has received graduate-level training in medicine, business, and laboratory research. Newsletter sign up (new and exciting developments) https://learningwithlowell.us12.list-manage.com/subscribe?u=08ed8a56013d8b3a3c01e27fc&id=6ecaa9189b Join this channel to get access to perks: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q/join https://youtu.be/-7gk195mhGc Over 321 books from 170 plus interviews over 5 years https://www.learningwithlowell.com/over-321-books-from-170-interviews-over-5-years-for-autodidacts/ PODCAST INFO: The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKS Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH RSS: https://www.learningwithlowell.com/feed/podcast/ Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA Website: https://www.learningwithlowell.com/ Kelsey moody links https://www.linkedin.com/in/kelsey-moody-phd-mba-55434421 https://ichorlifesciences.com/about/ Timestamps /show notes 00:00 Intro 00:30 How are ichor life sciences not out of business 02:30 why don't more people copy his business model 04:40 Finding the right investors 08:10 Sales in biotech 10:05 approach to hiring, managing, etc  11:20 Liquid liquid phase separation 16:00 Using phase separation  18:40 Protein vs Phase  22:24 Phase separation to find black swans  21:25 downside to phase separation 24:00 Phase separation being incorporated into portfolio / building tools.  27:11 Why choose phase separation / tool building 29:11 Future of ichor  30:10 Missing to meet that future 31:30 Build the headquarters / USA 33:33 Will they need $100 million 36:10 Startups / biotech wasting money   39:00 Continuity of vision / delusions / Moody in control  39:50 Getting the most from his team / biggest struggle 43:25 innovation days 45:30 Breakdown of startups in portfolio / interventions they're developing FanQ 49:20 How far from clinical trials Fanq 51:18 Lipid Nano Particle to deliver your Lysoclear enzyme FANQ 54:24 Lysoclear enzyme compared to other interventions  / macular degeneration 57:30 how will Lysoclear enzyme be applied elsewhere  59:30 Functional rejuvenation / aubrey de grey / repair future 01:02:30 Criticism Roche is leading these Ph2a trials / FanQ 01:07:18 Aubrey de grey LEV robust mouse rejuvenation study at ichor / insane! 01:10:50 Surprising / relieved developments from mouse rejuvenation study 01:12:18 building a ginkgo bioworks biobank 01:14:30 Surprising legal document 01:15:03 When was Kelsey happiest in life 01:16:07 Big sacrifice as a founder 01:18:50 Bryan johnson blueprint protocol / health optimization  01:20:33 Staying up to date.

An espresso-sized midweek podcast featuring one of my favourite Zestology guests. I'm back on Monday with the full podcast, but in the meantime, enjoy this quick burst of energy and enthusiasm - a short, energizing boost.

Show site: https://thinkfuture.com Breaking News In AI: https://aidaily.us --- In this episode, Chris reflects on a Bay Area Futurist meetup he attended years ago where life extension scientist, Aubrey De Grey, introduced the concept of potentially achieving immortality by extending human life by 20 years at a time. In contrast, a member of the President's Ethics Committee argued that humans should respect the natural cycle of birth and death. This led to an engaging debate on the ethics versus the feasibility of life extension. Chris introduces two types of thinkers: "accelerators", who believe in exploring all possibilities before delving into their ethical ramifications, and "decelerators", who prioritize ethical considerations before attempting any new venture. Drawing an analogy with a job offer scenario, Chris champions the accelerator perspective, emphasizing the significance of fostering choices, even if we don't always opt for them. He concludes by urging listeners to contemplate the myriad opportunities technology can present in the future. --- Send in a voice message: https://podcasters.spotify.com/pod/show/thinkfuture/message Support this podcast: https://podcasters.spotify.com/pod/show/thinkfuture/support

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The Longevity Summit Dublin took place from 17th to 20th August. In between presentations, Calum and David caught up with a number of the speakers to ask about their experiences at the Summit. This episode features three of these short interviews.First up is Aubrey de Grey, the President and Chief Science Officer of the LEV Foundation - a person deeply involved in the design and planning of the Summit. Next, we hear from Andrew Steele, who is an author and campaigner. The third interview features Liz Parrish, the CEO of BioViva Sciences and COO of Genorasis.Selected follow-ups:https://longevitysummitdublin.com/speakers/https://www.levf.org/https://maiabiotech.com/https://andrewsteele.co.uk/https://bioviva-science.com/https://www.bestchoicemedicine.com/https://www.genorasis.com/Audio engineering assisted by Alexander Chace.Music: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration

You'd be surprised to learn just how paradoxical and contentious the topic of human longevity is. On the one hand, almost every single person in this world wants to live longer. On the other hand, mainstream opinion generally holds nihilistic and dystopian views of a future where everyone lives longer. But the balance is gradually tilting as more and more people in different fields are seriously pondering the question of what society would look like if we had a longer lifespan and healthspan. In this episode of The Futurist Society Podcast, we are joined by one of the pioneers in the longevity space, Aubrey De Grey. One by one, Aubrey dispels the most common myths around longevity and the arguments often presented by naysayers to dispute the wisdom of extending the human lifespan. He also talks about the amazing developments in the field that show us that a post-aging society is indeed just out in the corner. Tune in for more! Love the show? Subscribe, rate, review, and share! http://thefuturistsociety.net/

An espresso-sized midweek podcast featuring one of my favourite Zestology guests. I'm back on Monday with the full podcast, but in the meantime, enjoy this quick burst of energy and enthusiasm - a short, energizing boost. Catch the whole episode here: https://sites.libsyn.com/66792/site/live-for-1000-years-with-scientist-and-author-dr-aubrey-de-grey-28  

Michael Rae is the author with Aubrey De Grey of “Ending Aging”, and “is the author of five scientific articles and commentaries in peer-reviewed scientific journals. Much of his work has been devoted to elucidating... Source

Jeho první věta ve studiu byla: “Někdy mám pocit, že mi je už přes sto let.” Avšak to jen měřeno množstvím životních zážitků a zkušeností. Biologicky je naopak nejméně o deset let mladší, než by vyplývalo z data narození. Aspoň to tvrdí. A ví to proto, že je šéfem a jedním ze spoluzakladatelů kliniky, kde se biologický věk měří.Pětapadesátiletý Petr Šrámek byl koncem května jedním z řečníků na konferenci Vogue Live, věnované dlouhověkosti, která se konala v Praze. Kromě toho, že řídí kliniku s pobočkami v Praze, na Floridě a Bahamách, je také zakladatelem investičního fondu Longevity Tech Fund.Investoři většinou z Česka mu svěřili peníze, aby investoval menší sumy, řádově milióny korun, do startupů začínajících podnikat právě v různých oborech, spojených se zdravým životem a dlouhověkostí. Spojují je dva zájmy, které má i Petr Šrámek: o technologie a o zdraví. Konkrétně možnosti žít déle, než je dnes běžné.Kolik to je? A opravdu se můžeme reálně dožívat věku přes sto let, jak slibují někteří lidé z této branže? Přičemž někteří slibují i mnohem víc? Pamatuju se, jak na prvním ročníku Singularity University v Praze tvrdil z pódia britský gerontolog Aubrey de Grey: už dnes tady v sále jsou lidé, kteří se dožijí 150 let.Problém je v tom, že nevíme jak. Ano, spousta objevů je velmi zajímavých, dokonce i některé experimenty na zvířatech jsou slibné. Ale je reálné prodloužit život lidí, a to dokonce takto výrazně? Můžeme se spolehnout na to, že medicínu a biologii, případně další příbuzné obory, čeká exponenciální změna? Jinými slovy, že přijdou zásadní až převratné objevy, které změní dnešní pohled na stárnutí?Samozřejmě jsem se na to Petra Šrámka zeptal. Zajímalo mě, v kterých oborech je případná disrupce nejpravděpodobnější, a jak reálné tyto výhledy opravdu jsou. A zeptal jsem se i na to, jestli jsme případně na prodloužení života běžné populace připraveni i jako společnost. A stojíme vůbec o to, žít takhle dlouho? Každý to samozřejmě vnímá jinak.Co vy? Můžete o tom přemýšlet během podcastu, ve kterém já se ptám a Petr Šrámek odpovídá. Každopádně přeji příjemný poslech.

Listen to Future Now 5.02.2023 Starship taking offThis week we are back in our home studio, though because of the inclement weather and failing solar, generator, and battery power, we a operating our entire studio on a tiny backup generator (Honda 2000i).  Despite our production challenges, the show came out quite well, with call-ins, including Billy Sunshine. Both Bobby Wilder and Master Now gave us a detailed analysis of some of the content from this week’s excellent online Longevity Conference, with clips from Peter Diamandis, Bruce Lipton, and Aubrey de Grey.   Enjoy! Brain Activity Decoder Transforms Thoughts Into Text

  Dr. Aubrey De Grey, a distinguished biomedical gerontologist, is a visionary in the field of aging research. His groundbreaking work has focused on finding ways to slow, prevent, and even reverse the aging process in humans and animals. As the founder of the SENS Research Foundation, Dr. De Grey has played a pivotal role in advancing the field of gerontology and biogerontology.  With his unique background and revolutionary approach to aging, Dr. Aubrey De Grey has upended conventional wisdom, sparking both intrigue and controversy as he seeks to extend healthy human life. But what will be the implications of his discoveries? Dr. De Grey's passion for exploring the possibilities of ageless living has led him to challenge conventional wisdom and inspire countless gerontologists to rethink their approach to aging. Look into the Strategies for Engineered Negligible Senescence (SENS) Foundation, founded by Dr. Aubrey De Grey, to learn more about their research and approach to combating aging and age-related diseases. Explore the concept of Longevity Escape Velocity, which Dr. De Grey has proposed as a way to stay one step ahead of the aging process through repeated application of damage repair therapies. Familiarize yourself with the history of science and the paradigm shifts that have occurred throughout time, as this can help provide context for understanding the resistance Dr. De Grey faced in proposing his ideas on aging. Research the different types of age-related damage and their potential impact on health, including Alzheimer's disease, cancer, arthritis, and sarcopenia, to understand the importance of focusing on health span rather than just life span. Consider the analogy between living organisms and manmade machines, as proposed by Dr. De Grey, to better understand the concept of damage accumulation and the potential for repair in both living and non-living systems. Investigate the concept of negligible senescence as coined by Caleb Finch and how this idea has influenced Dr. De Grey's approach to engineered negligible senescence. Look for opportunities to engage with the gerontology community and participate in discussions surrounding the potential for extending health spans and combating age-related diseases. Engineered Negligible Senescence Engineered Negligible Senescence (ENS) seeks to prevent or reverse the aging process, focusing on the repair of cellular and molecular damage that accrues over time. The underlying principle is that our biological age, determined by the wear and tear our bodies undergo, can be slowed down and potentially extended through vigilant maintenance. The ultimate goal of ENS is not simply to prolong life for its own sake, but to increase health span, curtailing age-related illnesses such as Alzheimer's, cancer, sarcopenia, and arthritis. Dr. Aubrey De Grey, a guest on the Beauty and the BS with Dr. Peter Grossman podcast, elaborated on the concept of ENS and its importance in addressing age-related health problems. Although his ideas faced resistance initially, De Grey remains confident in their potential benefits within his lifetime. By focusing on periodic, preventative maintenance, he believes it may be possible to delay the issues related to aging by 20 or 30 years, ultimately leading to longer, healthier lives. About the Host, Dr. Peter Grossman: https://grossmanmed.com/about Podcast Page: www.beautyandthebspodcast.com

With his unique background and revolutionary approach to aging, Dr. Aubrey De Grey has upended conventional wisdom, sparking both intrigue and controversy as he seeks to extend healthy human life. But what will be the implications of his discoveries? In this episode of Beauty and the BS with Dr. Peter Grossman, you will be able to:  1. Discover the significance of gerontology and biogerontology in addressing the aging process.  2. Understand engineered negligible senescence and its role in comprehensive periodic maintenance.  3. Explore how repairing molecular and cellular damage can counteract aging.  4. Learn about the potential of stem cell therapy as a cutting-edge damage repair strategy.  5. Delve into the controversy surrounding prolonged human life and the benefits it may hold. Dr. Aubrey De Grey, a distinguished biomedical gerontologist, is a visionary in the field of aging research. His groundbreaking work has focused on finding ways to slow, prevent, and even reverse the aging process in humans and animals. As the founder of the SENS Research Foundation, Dr. De Grey has played a pivotal role in advancing the field of gerontology and biogerontology.  With a keen understanding of the complex interplay between molecular and cellular damage, he has developed innovative strategies for promoting healthier, longer lives. Dr. De Grey's passion for exploring the possibilities of ageless living has led him to challenge conventional wisdom and inspire countless gerontologists to rethink their approach to aging. The key moments in this episode are: 00:00:08 - Introduction to Gerontology and Biomedical Gerontology 00:02:13 - Chronological Age versus Biological Age 00:05:03 - Aging and Damage Accumulation 00:11:20 - Engineered Negligible Senescence 00:16:50 - Postponing Aging to Battle Health Issues 00:17:58 - Life Expectancy vs. Lifespan 00:21:17 - Longevity and the Controversy 00:24:02 - Categorizing Aging Damage 00:25:12 - Cell Loss and Stem Cell Therapy 00:27:05 - The Importance of Classification The resources mentioned in this episode are: Look into the Strategies for Engineered Negligible Senescence (SENS) Foundation, founded by Dr. Aubrey De Grey, to learn more about their research and approach to combating aging and age-related diseases. Explore the concept of Longevity Escape Velocity, which Dr. De Grey has proposed as a way to stay one step ahead of the aging process through repeated application of damage repair therapies. Familiarize yourself with the history of science and the paradigm shifts that have occurred throughout time, as this can help provide context for understanding the resistance Dr. De Grey faced in proposing his ideas on aging. Research the different types of age-related damage and their potential impact on health, including Alzheimer's disease, cancer, arthritis, and sarcopenia, to understand the importance of focusing on health span rather than just life span. Consider the analogy between living organisms and manmade machines, as proposed by Dr. De Grey, to better understand the concept of damage accumulation and the potential for repair in both living and non-living systems. Investigate the concept of negligible senescence as coined by Caleb Finch and how this idea has influenced Dr. De Grey's approach to engineered negligible senescence. Look for opportunities to engage with the gerontology community and participate in discussions surrounding the potential for extending health spans and combating age-related diseases. Engineered Negligible Senescence Engineered Negligible Senescence (ENS) seeks to prevent or reverse the aging process, focusing on the repair of cellular and molecular damage that accrues over time. The underlying principle is that our biological age, determined by the wear and tear our bodies undergo, can be slowed down and potentially extended through vigilant maintenance. The ultimate goal of ENS is not simply to prolong life for its own sake, but to increase health span, curtailing age-related illnesses such as Alzheimer's, cancer, sarcopenia, and arthritis. Dr. Aubrey De Grey, a guest on the Beauty and the BS with Dr. Peter Grossman podcast, elaborated on the concept of ENS and its importance in addressing age-related health problems. Although his ideas faced resistance initially, De Grey remains confident in their potential benefits within his lifetime. By focusing on periodic, preventative maintenance, he believes it may be possible to delay the issues related to aging by 20 or 30 years, ultimately leading to longer, healthier lives. About the Host, Dr. Peter Grossman: https://grossmanmed.com/about Podcast Page: www.beautyandthebspodcast.com

In this episode, Max and Daniel sit down with the renowned Aubrey de Grey to discuss the connection between life extension and cryonics. They cover a wide range of topics, diving into the latest breakthroughs and obstacles in both fields.In this captivating conversation, they explore:The current state of rejuvenation technologiesRecent advances in longevity research over the past decadeChallenges still facing life extension sciencePerspectives on achieving longevity escape velocityProgress in robust mouse rejuvenation experimentsAubrey de Grey's journey into the world of cryonicsTanya Jones's new cryonics venture, KeiniceInnovative cryopreservation techniques using helium persufflationThe importance of cryonics vs life extensionThe potential for cryonics to become mainstreamThe search for major donors to support cryonics researchAnd much more! As always, you can find Max and Daniel over at the Cryosphere Cryonics discord server.Click here for the YouTube video version of this episode.Check out the brand new: Longevity Escape Velocity Foundation Follow Aubrey de Grey on Twitter. You can also find the Cryonics Underground Podcast and host Max Marty on Twitter too.

In this special series, Dr. Peter Grossman speaks to the world's foremost experts on the subject of living longer, healthier and the potential this emerging area of health could unlock now and in the future.  Introducing - The Longevity Series from Beauty and the BS with Dr. Peter Grossman The first episode drops tomorrow 4/12 with Dr. Grossman's guest, Dr. Aubrey De Grey.

World's Leading anti-aging scientist, Dr. Bill Andrews joins the program to share his latest research. He explains how humanity is very close to having an affordable anti-aging solution. He states that true anti-aging technology would solve over 90% of all diseases affecting humanity. This is why Big Pharma does not support true anti-aging for the masses. This is a ground breaking discussion with the world's leading scientist in anti-aging. Save 20% on Dr. Bill Andrew's anti-aging products at https://DefyTime.com - use code "SarahVIP2023"   Follow on my new Substack at SarahWestall.Substack.com See Important Proven Solutions to Keep Your from getting sick even if you had the mRNA Shot - Dr. Nieusma Protect your family and your assets with Silver & Gold - Contact info@milesfranklin.com, tell them "Sarah sent you" and receive excellent service and the lowest prices in the country, guaranteed! MUSIC CREDITS: "Do You Trust Me" by Michael Vignola, licensed for broad internet media use, including video and audio     See on Bastyon | Bitchute | Odysee | Rumble | Freedom.Social | SarahWestall.TV       Dr. Bill Andrews is the Founder and CEO of Sierra Sciences, a company focused on finding ways to extend human lifespan and health span through telomere maintenance. Telomeres are found at the tips of our chromosomes and have been shown, in thousands of scientific peer-reviewed studies, to be the clock of aging in humans. When telomeres get shorter, we get older, and our health declines. As a scientist, athlete, and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey. See www.theimmortalists.com/watch. Bill is known for being a scientist first, focusing on scientific research, allowing others, instead, to market the products that his company discovers. Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, though his passion has always been aging. In the early-to-mid 1990s, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences. Learn more about Dr. Bill Andrews at www.sierrasci.com      

World's Leading anti-aging scientist, Dr. Bill Andrews joins the program to share his latest research. He explains how humanity is very close to having an affordable anti-aging solution. He states that true anti-aging technology would solve over 90% of all diseases affecting humanity. This is why Big Pharma does not support true anti-aging for the masses. This is a ground breaking discussion with the world's leading scientist in anti-aging. Save 20% on Dr. Bill Andrew's anti-aging products at https://DefyTime.com - use code "SarahVIP2023" Follow on my new Substack at SarahWestall.Substack.com See Important Proven Solutions to Keep Your from getting sick even if you had the mRNA Shot - Dr. Nieusma Protect your family and your assets with Silver & Gold - Contact info@milesfranklin.com, tell them "Sarah sent you" and receive excellent service and the lowest prices in the country, guaranteed! MUSIC CREDITS: "Do You Trust Me" by Michael Vignola, licensed for broad internet media use, including video and audio     See on Bastyon | Bitchute | Odysee | Rumble | Freedom.Social | SarahWestall.TV       Dr. Bill Andrews is the Founder and CEO of Sierra Sciences, a company focused on finding ways to extend human lifespan and health span through telomere maintenance. Telomeres are found at the tips of our chromosomes and have been shown, in thousands of scientific peer-reviewed studies, to be the clock of aging in humans. When telomeres get shorter, we get older, and our health declines. As a scientist, athlete, and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey. See www.theimmortalists.com/watch. Bill is known for being a scientist first, focusing on scientific research, allowing others, instead, to market the products that his company discovers. Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, though his passion has always been aging. In the early-to-mid 1990s, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences. Learn more about Dr. Bill Andrews at www.sierrasci.com

Peter James is one of the world's most successful crime writers. His "Roy Grace" series, about a detective in Brighton, England, near where Peter lives, has produced a remarkable 19 consecutive Sunday Times Number One bestsellers. His legions of devoted fans await each new release eagerly. The books have been televised, with the third series of "Grace", starting John Simm, being commissioned for next year.Peter has worked in other genres too, having written 36 novels altogether. When Calum first met Peter in the mid-1990s, Peter's science fiction novel “Host” was generating rave reviews. It was the world's first electronically published novel, and a copy of its floppy disc version is on display in London's Science Museum.Peter is also a self-confessed petrol-head, with an enviable collection of classic cars, and a pretty successful track record of racing some of them. The discussion later in the episode addresses the likely arrival of self-driving cars. But we start with the possibility of mind uploading, which is the subject of “Host”.Selected follow-up reading:https://www.peterjames.com/https://www.alcor.org/Topics in this conversation include:*) Peter's passion for the future*) The transformative effect of the 1990 book "Great Mambo Chicken and the Transhuman Condition"*) A Christmas sojourn at MIT and encounters with AI pioneer Marvin Minsky*) The origins of the ideas behind "Host"*) Meeting Alcor, the cryonics organisation, in Riverside California*) How cryonics has evolved over the decades*) "The first person to live to 200 has already been born"*) Quick summaries of previous London Futurists Podcast episodes featuring Aubrey de Grey and Andrew Steele*) The case for doing better than nature*) Peter's novel "Perfect People" and the theme of "designer babies"*) Possible improvements in the human condition from genetic editing*) The risk of a future "genetic underclass"*) Technology divides often don't last: consider the "fridge divide" and the "smartphone divide"*) Calum's novel "Pandora's Brain"*) Why Peter is comfortable with the label "transhumanist"*) Various ways of reading (many) more books*) A thought experiment involving a healthy 99 year old*) If people lived a lot longer, we might take better care of our planet*) Peter's views on technology assisting writers*) Strengths and weaknesses of present-day ChatGPT as a writer*) Prospects for transhumans to explore space*) The "bunker experiments" into the circadian cycle, which suggest that humans naturally revert to a daily cycle closer to 26 hours than 24 hours*) Possible answers to Fermi's question about lack of any sign of alien civilisations*) Reflections on "The Pale Blue Dot of Earth" (originally by Carl Sagan)*) The likelihood of incredible surprises in the next few decades*) Pros and cons of humans driving on public roads (especially when drivers are using mobile phones)*) Legal and ethical issues arising from autonomous cars*) Exponential change often involves a frustrating slow phase before fast breakthroughs*) Anticipating the experience of driving inside immersive virtual reality*) The tragic background to Peter's book "Possession"*) A concluding message from the science fiction writer Kurt VonnegutMusic: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration

Christin Glorioso MD, Phd, & founder of NeuroAge Therapeutics and Longevity Global. Today we are digging into the drama of supplements and specifically metformin & Nir Barzilai, research into Alzheimer's, Aubrey De Grey concerns, David Sinclair Yamanaka factor mouse studies explained, Bryan Johnson 2 million a year longevity blueprint, brain age, books, and more.   Also, … Brain Longevity, Supplement concerns, & Alzheimers Drama w/Dr. Christin Glorioso CEO of NeuroAge 156 Read More »

Kevin Perrott's thesis on aging and its impact on the organization Open Cures. The episode also delves into the use of multi-omic data and the importance of biobank donations and giving blood. The conversation touches on the potential for colleges and students to be a focus for Open Cures and highlights bottlenecks that the organization … Kevin Perrott: Longevity, Aubrey De Grey, Michael Levin, OpenCures, Multi Omic Data, AI, ML – 152 Read More »

Aubrey De Grey discusses the progress and potential of therapies related to his ideas on anti-aging medicine, including the four therapies that will be tested in a mouse rejuvenation trial. He also shares his thoughts on partnering with organizations and individuals in the field, integrating AI into his work, and the importance of structure in … Aubrey De Grey:longevity escape velocity, longevity, mouse rejuvenation, Altos Labs, Yamanaka factor #149 Read More »

This week we interview the phenomenal Aubrey De Grey, the world's foremost authority on longevity and developing strategies to slow or eliminate aging altogether. The author of The Mitochondrial Free Radical Theory of Aging (1999) and Ending Aging (2007), De Grey is probably best  known for the concept of Longevity Escape Velocity, a view that soon medical technology will enable human beings to prevent age-related deterioration, and eventually eliminated aging entirely.

Shermer and Ward discuss: religious immortality • Church of Perpetual Life in Florida • what it means to live forever • why lives have doubled in length the past century • Stein's Law: things that can't go on forever won't • Why do we age and die? • how to live to 100, 1000, 10,000 years • escape velocity to reach immortality • Aubrey de Grey's program • tech billionaires programs • transhumanists/extropians • diet, exercise, supplements, stem cells, telomeres, and other aging hacks • Ray Kurzweil • cryonics • nanotechnology • brain preservation • mind uploading and digital immortality • Ernest Becker and Terror Management Theory Peter Ward is a British business and technology reporter whose reporting has taken him across the globe. Reporting from Dubai, he covered the energy sector in the Middle East before earning a degree in business journalism from the Columbia University Graduate School of Journalism. His writing has appeared in Wired, The Atlantic, The Economist, GQ, BBC Science Focus, and Newsweek.