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Listener Q&A where Andy talks about: Should Roth conversion analysis look at marginal or effective tax rates ( 4:21 )His thoughts on why qualified Roth account distributions might eventually be included in certain measures of Modified Adjusted Gross Income ("MAGI") ( 8:28 )What other MAGIs are potentially impacted and should be watched out for with doing Roth conversions ( 12:38 )The difference between "directionality" and "precision" in retirement planning ( 20:40 )Is it reasonably for an advisor to charge you extra for outsourcing some of their investment management to a separately managed or sub-managed account ( 25:38 )His thoughts of reinvesting a deferred compensation plan to all cash when the plan will soon begin paying out its deferred payments ( 29:34 )His thoughts on using multiple dividend and fixed income funds to create a "high income sleeve" for near-term distribution needs ( 35:25 )Whether it's accurate that you can indirectly file a tax return extension simply by making an online tax payment and select "extension" as the reason for the payment ( 39:05 )Can a minor with less than $400 of self-employment income not file a tax return yet still be eligible to contribute to a Roth IRA ( 44:56 )How he helps clients balance Fear of Missing Out ("FOMO") and Fear of Running Out ("FORU") ( 52:04 )How much of his planning work with clients is computational vs psychological ( 54:42 )His thoughts on the gamification of investing, and the prediction markets ( 58:11 )Why there are so many different funds like buffered ETFs and option trading ETFs, at higher expense ratios, when many can just invest in a few basic low-cost ETFs ( 1:00:36 )To send Andy questions to be addressed on future Q&A episodes, email andy@andypanko.comAndy's LinkedIn profile: https://www.linkedin.com/in/andypanko/Links in this episode:Tenon Financial monthly newsletter/blog - Retirement Planning InsightsYouTube channel - Retirement Planning Education (formerly Retirement Planning Demystified)Retirement Planning Education website - www.RetirementPlanningEducation.com
Brandon Sedloff and Mike Cordingley explore what it takes to build durable, scalable private markets firms in an era of constant disruption. Mike leads the strategy, leadership, and advisory group at Ferguson Partners, a talent management and strategic advisory firm that works with about half of the public REITs and many of the largest private equity and real estate platforms. His work takes him inside these organizations as they navigate fundamental shifts in leadership, operating models, and business strategy. The conversation on The Distribution covers how private markets firms have reached an inflection point where the entrepreneurial, founder-led models that drove early growth now face pressure from rising costs, compressed fees, and the need to retain next-generation talent. Mike explains why founders must move beyond an investment thesis to develop a true enterprise strategy, and why the CEO's role is evolving from chief decision-maker to platform architect who distributes decision rights across the organization. They discuss: - Why succession planning has become a business imperative as founder-led firms face generational transitions - How decision architecture creates competitive advantage by pushing decisions closer to where value is created - Why AI represents a people transformation challenge, not just a technology implementation - The concept of zero-based org design and what it means to treat operating models as design choices rather than fixed structures This episode offers practical frameworks for leaders wrestling with how to scale their organizations, develop talent, and prepare for the next phase of growth in private markets. Topics: (00:00:00) - Intro (00:00:33) - Why founders need an enterprise strategy (00:02:20) - Mike's path to management consulting (00:07:17) - The role of consultants in private markets (00:09:29) - Four big trends shaping private markets today (00:13:27) - How we got to this inflection point (00:17:49) - Navigating founder succession and talent retention (00:30:59) - Decision architecture as a competitive advantage (00:38:59) - Operating model as a design choice (00:42:28) - Distributed accountability and data access (00:46:27) - Precision talent matching (00:50:40) - AI as a people transformation, not just efficiency (00:53:17) - Closing Links: Brandon on LinkedIn - https://www.linkedin.com/in/brandonsedloff/ Mike on LinkedIn - https://www.linkedin.com/in/mikecordingley/ Ferguson Partners - https://www.fergusonpartners.com/ Juniper Square - https://www.junipersquare.com/
Hello, Voices of the Bench community. This is Casey Baldwin with Ivoclar. If you've been curious about fast-firing zirconia to improve efficiency but aren't convinced it can deliver predictable, high-quality results, I'd encourage you to connect with us. Our new IPS emax Zirconia, offers multiple fast-fire protocols designed to help you save valuable production time while maintaining consistent outcomes. Time is money in every lab. Don't wait. Reach out today and discover how IPS emax Zirconia can help streamline your workflow. As full-arch dentistry continues to grow, so do the demands on today's dental laboratories. That's why Knight Dental recently launched SimplyARCH Studio, a dedicated production environment built exclusively for full-arch restorations. To support this specialized workflow, Knight invested in an XTCERA milling system and carefully evaluated multiple CAM software solutions before choosing hyperDENT. The decision came down to exceptional milling quality, minimal hand finishing, and impressive production efficiency. But what truly set hyperDENT apart was the implementation process. From the very beginning, the team provided more than software training—they shared the knowledge and experience needed to build an optimized workflow for complex full-arch cases. With proven expertise in advanced milling strategies and laboratory production, hyperDENT helped ensure SimplyARCH Studio was designed for long-term success from day one. This week, Elvis and Barb are coming to you from the FDLA Symposium at the GPS Digital RPD booth with two conversations that prove one thing: dental technology never stops evolving. First up, Chris Bradley from SmileLine USA returns to the podcast alongside technician, educator, and lab owner Richard Wodzinski, with Dawn Roniger from GC America joining the discussion. What starts as a conversation about "sexy brushes" quickly turns into a deep dive into one of the most intriguing shade-matching workflows you'll hear about. Richard explains how the OptiShade camera and Matisse software work together to create incredibly accurate shade recipes for everything from monolithic zirconia to layered ceramics and even gingiva. They also discuss the latest Creation Magic Color system, hands-on education, custom shade appointments, and why reducing remakes isn't just good for labs—it's better for doctors and patients too. Add in some FDLA leadership talk and a shared passion for education, and you've got a conversation packed with practical ideas and plenty of laughs. Then Elvis and Barb sit down with Kaveh Shams, Branch Manager for Zirkonzahn Canada, whose journey into digital dentistry spans London, Italy, and Canada. Kaveh shares how his admiration for Enrico Steger and Zirkonzahn eventually led to his dream job, while also offering a fascinating look into the company's history, philosophy, and commitment to education. From the origins of Exocad and custom CAM strategies to modular milling systems, open architecture, and Zirkonzahn's incredible Military School program that trains the next generation of technicians, this conversation is full of insight into what makes one of dentistry's most respected digital companies tick. It's an inspiring story of passion, persistence, and why great technology always starts with great technicians.Special Guests: Chris Bradley, Dawn Roniger , Kaveh Shams, and Rich Wodzinski.
This week we talk about: Zoho CRM: Layout Rules Enhancements Zoho Bigin: Payment Link Automation Enhancements Zoho Inventory: June 2026 Inventory and Fulfillment Enhancements Our Code Share, Read, Tip and Question of the Week Read the show notes: https://zenatta.com/episode-415/ ⚖️ Avalara AvaTax for Zoho CRM ⚖️ Accurate Tax. Zero Guesswork.
After spending time with the new Savage 110 Carbon Hunter in the field, Will Cooper breaks down the features, design, and technology that set this rifle apart.In this episode of Geared For The Hunt, you'll learn about the rifle's carbon fiber-wrapped barrel, lightweight construction, AccuFit V2 system, AccuTrigger, and overall performance characteristics. Will shares his firsthand impressions and explains how these features can benefit hunters and precision shooters looking for a lightweight, accurate rifle platform.Whether you're researching your next hunting rifle or simply interested in modern firearm design and performance, this educational overview covers what makes the Savage 110 Carbon Hunter one of Savage's latest innovations.Learn more about the Savage 110 Carbon Hunter:https://savagearms.com/firearms/model/110-carbon-hunter FOLLOW JOSH & WILL: Josh: https://www.instagram.com/josh.j.dahlke/ Will: https://www.instagram.com/willtcooper/ DOWNLOAD HUNTSTAND https://www.huntstand.com/subscriptions/ HUNTSTAND FIELD NOTES https://www.huntstand.com/fieldnotes/ GET SOCIAL: Instagram: https://www.instagram.com/huntstand/ Facebook: https://www.facebook.com/HuntStand TikTok: https://www.tiktok.com/@huntstandofficial Learn more about your ad choices. Visit megaphone.fm/adchoices
Late-stage deals can appear secure once the buyer has accepted the product and the business case, but that is often when the risk feels most personal. In today's segment, Randy Riemersma explains why deals inside the final 10 yards are won or lost on buyer confidence and how elite sellers remove doubt through executive alignment, credible proof points, consistent communication with the champion, and a clear business-level point of view. The conversation gives revenue leaders a sharper way to evaluate late-stage deal risk and reinforces why belief, preparation, and execution matter when the buyer is preparing to make a high-stakes decision. Randy Riemersma is the founder of Sell with Precision, where he helps sales leaders strengthen go-to-market execution, leadership effectiveness, and sales operating discipline. He has spent decades in B2B sales, leadership, consulting, and executive coaching, with a focus on helping teams sell with greater clarity, precision, and business relevance. Connect with Randy: LinkedIn Website Resources mentioned: The Happiness Lab with Dr. Laurie Santos - The Hidden Beliefs That Shape Your Happiness with Shawn Achor Listen to the full episode: The Hidden Cost of False Velocity with Randy Riemersma Hosted by five-time CRO John McMahon and Force Management Co-Founder John Kaplan, the Revenue Builders podcast goes behind the scenes with the sales leaders who have been there, done that, and seen the results. This show is brought to you by Force Management. We help companies improve sales performance, executing their growth strategy at the point of sale. Connect with Us: LinkedInYouTubeForce Management
Most people assume that if their annual physical comes back normal, they are healthy. But what if traditional lab work misses important clues about metabolic health, hormone function, inflammation, and biological aging?In this episode, Dr. Jeff Armstrong speaks with Michael Zaghikian, Co-Founder and Clinical Strategist at Evolve Anti-Aging & Wellness, about the growing field of biological optimization and personalized medicine. They explore how advanced diagnostics may help identify hidden drivers of fatigue, weight gain, poor recovery, and declining vitality, while discussing the opportunities and limitations of hormone optimization, peptide therapies, GLP-1 medications, and other emerging approaches to longevity. This conversation offers a practical look at how data-driven health strategies may help people improve both healthspan and quality of life as they age.Learn more at https://evolveantiaging.comPlease, support The Aging Well Podcast by hitting the ‘like' button, subscribing/following the podcast, sharing with a friend, and….Tip Jar! All donations support this podcast to keep it going. https://paypal.me/theagingwellpodcastBUY the products you need to… age well from our trusted affiliates and support the mission of The Aging Well Podcast. (We receive commission on these purchases. Thank you.)The Aging Well Podcast merchandise | Show how you are aging well | Use the promo code AGING WELL for free shipping on orders over $75 | https://theagingwellpodcast-shop.fourthwall.com/promo/AGINGWELLAuro Wellness | Glutaryl—Antioxidant spray that delivers high doses of glutathione (“Master Antioxidant”) and the new Copper Tripeptide (GHK-Cu) | 10% off Code: AGINGWELL at https://aurowellness.com/agingwellpodcastNutritional Biochemical Inc. (NBI) | Trusted supplement. NBI stands 100% behind the quality of their formulations and the science on which they're based. | Click the following link and use the discount code AGINGWELL for 10% off: https://shop.nbihealth.com/agingwellJigsaw Health | Trusted supplements. “It's fun to feel good.” | Click the following link and use the discount code AGINGWELL for 10% off: https://bit.ly/4ks3Y0OBerkeley Life | Optimize nitric oxide levels | Purchase your starter kit at a 15% discount | Use the promo code: AGINGWELL15 | https://berkeleylife.pxf.io/c/6475525/3226696/31118Oxford Healthspan | Primeadine®, a plant-derived spermidine supplement | 10% off code: AGINGWELL | https://www.oxfordhealthspan.com/AGINGWELLKneeMo | A smart device programmed to reduce your knee pain and keep you moving. | Click the following link and use the discount code AGINGWELL15 for 15% off: https://thekneemo.com/ref/agingwellProlon | The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts. | For the best available discount always use this link: https://prolonlife.com/theagingwellpodcastL-Nutra Health | The medical division of L-Nutra, focused on helping people manage and potentially reverse chronic health conditions, like type 2 diabetes, prediabetes, insulin resistance, and obesity, using personalized, lifestyle-based programs grounded in evidence, not prescriptions. | Use this link: https://l-nutrahealth.com/theagingwellpodcastFusionary Formulas | Combining Ayurvedic wisdom with Western science for optimal health support. | 15% off Code: AGINGWELL | https://fusionaryformulas.com?sca_ref=9678325.IHg5xYhdOzzke8ZrDr Lewis Nutrition | Fight neurodegeneration and cognitive decline with Daily Brain Care by Dr Lewis Nutrition—a proven daily formula designed to protect and restore brain function. | 10% off code: AGINGWELL or use the link: https://drlewisnutrition.com/AGINGWELL
Welcome to The Turf Zone podcast. This episode features the article “Keeping the Game Green: Fall Overseeding Sports Fields” written by David Lawrence with the Alabama Cooperative Extension System. For many turf managers, fall marks a welcome transition time when cooler temperatures slow turf growth and the frantic pace of summer maintenance finally eases. The start of the fall season often brings a sense of relief and satisfaction as turf maintains its green color without the surge of growth that demands constant mowing and management. For some, it's a rare chance to pause, reflect on the successes and challenges of the summer, and prepare for the months ahead. However, not everyone gets to slow down. For many sports field managers, fall is one of the busiest times of the year. Football season is in full swing, and fields endure relentless stress from practices, games, and unpredictable weather. While most fans focus on the players and the scoreboard, turfgrass professionals can't help but notice the condition and aesthetic appeal of the playing surfaces when attending a game or watching on television. Beyond appearances, turf managers know that the quality of the surface directly affects player safety. Dense, healthy turf cushions impact, reduces divots and holes, and helps minimize the risk of slips and injuries. One of the most effective ways to maintain both aesthetics and playability during this demanding stretch is through overseeding bermudagrass fields with perennial ryegrass. Across the southeastern U.S., bermudagrass growth slows dramatically in the fall as temperatures drop and daylength shortens, limiting the plant's ability to recover from traffic and wear. Even during milder years, reduced sunlight and cooler nights simply don't allow bermudagrass to sustain vigorous growth and recover after the pounding of a typical football season. That's where perennial ryegrass shines. Its deep-green color, fine texture, and excellent striping potential make it the go-to choice for achieving high-quality field appearance. Beyond visual appeal, perennial ryegrass establishes quickly, provides dense coverage, and enhances traction, all key factors in maintaining safe and consistent playing conditions. A well-established ryegrass overseed offers a stable, even surface that keeps athletes confident in their footing throughout the season. Most athletic field managers begin overseeding in mid-September, adjusting timing based on local climate and field schedules. Typical seeding rates range from 8 to 12 pounds per 1,000 square feet, with periodic supplemental applications to fill divots and high-wear zones such as between hash marks and along sidelines. Proper irrigation and fertility management are critical during establishment. It's important to provide consistent moisture to promote uniform germination, while avoiding excessive wetness that could compromise field conditions during play. Managers should also monitor soil temperatures closely, as seeding too early can stress young ryegrass, while seeding too late can delay establishment as cooler weather sets in. Of course, overseeding comes with challenges. Weed management requires careful planning to avoid damaging both ryegrass and the underlying bermudagrass. Annual bluegrass (Poa annua) remains one of the most persistent issues on overseeded fields. Herbicide options are limited, and success depends heavily on timing for both pre-emergent and post-emergent applications. Precision and patience are essential for achieving control while minimizing damage to desirable turf species. The following provides examples of commonly used products, though it does not represent a complete list of all labeled options. Pre-emergent herbicides such as prodiamine or pronamide can be applied prior to overseeding but must be applied several weeks before the expected overseed date to allow time for herbicide degradation before seeding. Some sulfonylurea herbicides such as foramsulfuron or rimsulfuron can be applied one week prior to overseeding. These products that can be used do not have any pre-emergent activity but will control any annual bluegrass that has already germinated. This application can be beneficial especially when the overseeding date is later into the fall after annual bluegrass germination. Post-emergent options for overseeded turf include ethofumesate, amicarbazone, paclobutrazol, and bispyribac. These products can be temperature dependent so careful planning should be considered when making an application. Some PGRs such as ethephon can reduce or prevent seedhead formation on annual bluegrass when applied at the proper time. Applicators should read all herbicide labels to ensure turfgrass safety while providing the best opportunity for annual bluegrass control. Another management hurdle arises during spring transition. If not carefully managed, perennial ryegrass can delay bermudagrass green-up, leading to thin, uneven turf. Many managers opt for chemical removal of ryegrass once bermudagrass begins active growth, though the timing varies depending on field use and athletic schedules. Sulfonylurea herbicides are commonly used for ryegrass transition. However, due to the increased incidence of ALS herbicide resistance, many managers may need to rely on other products such as pronamide for ryegrass transition if annual bluegrass is present. The goal is to remove ryegrass early enough to allow bermudagrass to recover, yet late enough to maintain playability for spring sports. When managed thoughtfully, fall overseeding with perennial ryegrass delivers multiple benefits such as enhanced color, improved traction, extended playability, and safer, more resilient fields. It's not just about keeping the turf green when bermudagrass slows down; it's about protecting players, preserving field quality, and ensuring that every game, practice, and play happens on a quality surface. For many sports field managers, overseeding is not simply a seasonal task but a key component of year-round field performance and visual quality. You have been listening to The Turf Zone Podcast. Follow The Turf Zone on X, Facebook and LinkedIn for all things turfgrass, featuring podcasts, magazines, events and more. The post Keeping the Game Green: Fall Overseeding Sports Fields appeared first on The Turf Zone.
On this week's episode of Precision Talk we chat with Technology Advisor Jay Robinson about where farmers are losing yield. How to fix it and what to expect. For more information or a personalized ROI Review give us a call at 712-744-4468 online at htsag.com
On this episode we nerd out on the study that the crew over at Precision Cut Archery, Yates In The Backcountry and many more collaborated on. This study has tons of data so the link will be down below for you to go check it out and see more then what we could cover on a podcast.Thanks for listening!John 3.32026 Arrow Study Results: https://www.precisioncutarchery.com/researchWiseEye Tech Trail Camerashttps://wiseeyetech.com/Code: bornagain for 10% off! Premier Outdoorshttps://premieroutdoors.us/Code at the register: Podcast 2025 for 10% off! (exclusions apply)Rogue Bowstringshttps://www.roguebowstrings.comCode: BornAgain20 for 20% off!Latitude Outdoorshttps://www.latitudeoutdoors.comCode: BORNAGAIN for 15% off!
We love to hear from our listeners. Send us a message.Episode 133 of Cell & Gene: The Podcast features Host Erin Harris' discussion with Aprea Therapeutics' CEO, Dr. Oren Gilad. They cover the evolution of precision oncology, the science of synthetic lethality, and how Aprea is developing next-generation therapies that target cancer's unique genetic vulnerabilities while improving safety and efficacy. Dr. Gilad also shares insights into biomarker-driven drug development, where precision medicine is headed as researchers pursue more effective treatments for patients with difficult-to-treat solid tumors, and more.Subscribe to the podcast!Apple | Spotify | YouTubeVisit my website: Cell & GeneConnect with me on LinkedIn
In this episode, we examine the July 7, 2026 CENTCOM retaliatory strikes that hit more than 80 Iranian targets—including air defenses, coastal radar, anti-ship missiles, and over 60 IRGC small boats—following attacks on three commercial vessels transiting the Strait of Hormuz. Drawing directly from my background as a Navy SEAL, I break down the tactical execution, the likely role of special operations forces in targeting and maritime security, and the strategic context of renewed U.S. measures including the “Guardian of Hormuz” posture and blockade elements. Listeners will walk away with a clear operator-level understanding of escalation control, precision effects in contested waterways, and what these developments signal for future missions in the region.
In this episode of The Poultry Nutrition Blackbelt Podcast, Dr. Thiago Noetzold, an independent consultant specializing in agricultural statistics and data analysis, explains the factors influencing broiler breeder hatchability and fertility. Topics include male management, flock uniformity, precision feeding, separate nutrition programs, and practical strategies to improve reproductive performance throughout the production cycle. Listen now on all major platforms!Click here to read the full research article!"Hatchability has declined across North America during the past decade, showing that management practices have become increasingly important for maintaining reproductive performance throughout the production cycle."Meet the guest: Dr. Thiago Noetzold is a veterinarian with a master's degree in Animal Science and a PhD focused on poultry research. After completing postdoctoral research at the University of Alberta, he became an independent consultant specializing in statistics and data analysis for agriculture. His work emphasizes broiler breeder performance, fertility, and data-driven decision-making. Listen to Dr. Thiago Noetzold on The Poultry Nutrition Blackbelt Podcast, available on all major platforms.Liked this one? Don't stop now — Here's what we think you'll love!What you'll learn:(00:00) Highlight(02:10) Introduction(03:26) Hatchability trends(05:21) Male management(08:27) Separate nutrition(10:27) Precision feeding(13:13) Future strategies(15:22) Closing thoughtsThe Poultry Nutrition Blackbelt Podcast is trusted and supported by innovative companies like:* Kemin* Fortiva- Poultry Science Association- Anitox- WiseVAs- ZentrixOS- Zentrix Insights- DietForge- The Owner's Box- Elevate
Don Forsman has 45 years of building homes and is currently building his own, which means he has never been more dangerous in a conversation about never evers and always always. He and Mark cover why you can't blame the drywaller for a bad HVAC vent, how external insulation brought wood siding back from the dead, and why precision is the goal and perfection is a trap. This one is basically a masterclass disguised as two guys talking in a sunroom. Support the show - https://www.curiousbuilderpodcast.com/shop See our upcoming live events - https://www.curiousbuilderpodcast.com/events The host of the Curious Builder Podcast is Mark D. Williams, the founder of Mark D. Williams Custom Homes Inc. They are an award-winning Twin Cities-based home builder, creating quality custom homes and remodels — one-of-a-kind dream homes of all styles and scopes. Whether you're looking to reimagine your current space or start fresh with a new construction, we build homes that reflect how you live your everyday life. Sponsors for the Episode: Pella Website: https://www.pella.com/ppc/professionals/why-wood/ Contractor Coalition Summit: Website: https://www.contractorscoalitionsummit.com/ Where to find the Guest: Website: https://www.welchforsman.com/ Instagram: https://instagram.com/welchforsman Where to find the Host: Website - https://www.mdwilliamshomes.com/ Podcast Website - https://www.curiousbuilderpodcast.com Instagram - https://www.instagram.com/markdwilliams_customhomes/ Facebook - https://www.facebook.com/MarkDWilliamsCustomHomesInc/ LinkedIn - https://www.linkedin.com/in/mark-williams-968a3420/ Houzz - https://www.houzz.com/pro/markdwilliamscustomhomes/mark-d-williams-custom-homes-inc
In this week's episode of Parallax, Dr Ankur Kalra is joined by Dr Chris Maroules, National Director for Cardiac Imaging at SimonMed and co-director of Innovation Health. Together, they explore why coronary CTA, now a Class 1 recommendation in the 2021 ACC/AHA chest pain guidelines, has become the standard first-line non-invasive test, and why proficiency in cardiac CT is essential for cardiology trainees in 2026. The conversation shifts from traditional risk scores to direct disease assessment, highlighting the power of coronary CTA to identify and quantify plaque burden. Dr Maroules discusses high-risk plaque features, the limitations of calcium scoring, and the evolving role of FFRCT, before outlining a future of AI-enabled screening and precision prevention. He concludes with practical advice for fellows, encouraging Level 2 certification to stay ahead in an increasingly imaging-driven field. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.
This week we talk about: Zoho Creator: Zia AI Configuration Enhancements Zoho Inventory: Inventory Operations with Zoho MCP Zoho Recruit: Color-Coded Blueprint Transitions Our Code Share, Read, Tip and Question of the Week Read the show notes: https://zenatta.com/episode-414/ ⚖️ Avalara AvaTax for Zoho CRM ⚖️ Accurate Tax. Zero Guesswork.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Although many GISTs can be effectively treated with targeted therapies, their response to treatment depends largely on the specific genetic alterations driving tumor growth. Advances in molecular testing have transformed the management of these tumors, allowing clinicians to tailor treatment based on each patient's genetic profile. A case report published in Volume 17 of Oncotarget, titled “Small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation: A case report,” describes an exceptionally rare case involving a patient whose tumor carried two genetic alterations that are traditionally considered mutually exclusive. Full blog post - https://www.oncotarget.org/2026/07/13/rare-genetic-combination-in-gastrointestinal-tumor-offers-new-insights-into-precision-cancer-care/ DOI - https://doi.org/10.18632/oncotarget.28863 Correspondence to - Joseph G. Crompton - jcrompton@mednet.ucla.edu Abstract video - https://www.youtube.com/watch?v=eB_QG2vBNCE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28863 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, GIST, KIT duplication, SDHC mutation, genetic testing, case report To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
- Meta Iris accelerator chip - New class of vendors in Chips - ORNL on-prem Quantum Computer - Satoshi Matsuoka's papers on Precision, Memory, Open Models - Is the U.S. “blowing it” in AI? [audio mp3="https://orionx.net/wp-content/uploads/2026/07/HPCNB_20260713.mp3"][/audio] The post HPC News Bytes – 20260713 appeared first on OrionX.net.
Precision and Professionalism: Highlights from the 2026 Central Ontario Regional Truck Driving Championships Join Bruce Outridge on the Lead Pedal Podcast as we head to the Kitchener Memorial Auditorium for the 2026 Central Ontario Regional Truck Driving Championships! We're speaking with the industry's most skilled professional drivers about the art of precision driving and chatting with the sponsors who make this incredible showcase of safety and expertise possible. Discover what it takes to compete at the regional level and why these events are the backbone of our industry's commitment to safety. Learn more about the competition at www.cortdc.com At Bison – They Put Safety First! Bison's "Right to Decide" Policy gives every Driver their ultimate protection. Drivers make the final decision if it is safe to drive and Bison actively encourages Driver's use of this policy. You can learn more about Bison and the opportunities available at www.bisondriving.com or call 1-800-527-5781 @BisonTransport #bisontransport Get The Best Truck Parts for Your Truck at Chrome Supply Warehouse Chrome Supply Warehouse has the best selection of chrome and truck parts in Ontario Canada. Located in Belleville Ontario on the North side of the Highway with lots of truck parking makes it a great place to stop. Stop in for a break or to check on their cool interior, exterior, and custom parts. Learn more online at www.chromesupplywarehouse.com Keep Your Workplace Safe With DriverCheck DriverCheck is a leader in drug and alcohol, cognitive, and workplace testing helping employers have a safe workplace for their staff. Learn how DriverCheck can help you be safe at www.drivercheck.ca About the Podcast The Lead Pedal Podcast for Truck Drivers helps truck drivers improve their truck driving careers, trucking businesses as owner operators, CDL skills, find trucking jobs, and offer trucking career tips. Learn about the trucking benefits and salaries as a professional truck driver through interviews and tips related to the North American Trucking Industry. The Lead Pedal Podcast is a Canadian based trucking podcast focused on trucking in Ontario, Canada. LISTEN TO THE PODCAST- The show is available at www.theleadpedalpodcast.com , Apple Podcasts, Spotify, iHeartradio, and other popular podcast platforms. Thanks for listening! The Lead Pedal Podcast for Truck Drivers talks all things trucking for people in the transportation industry helping them improve their business and careers. Interviews with industry professionals and truck drivers, trucking equipment information, event coverage, and other features on the industry are meant to be helpful for truck drivers and those in transportation. The Lead Pedal Podcast for Truck Drivers has main episodes released every Monday, Wednesday, and Friday with bonus material on other days. You can learn more about the host and show on our website and make sure to SUBSCRIBE to the show on your favourite podcast platform. www.theleadpedalpodcast.com What does The Lead Pedal Podcast mean? The Lead (pronounced - Led) stands for acceleration or fast-track of your career or business. It is a play on words and we certainly are not here promoting speeding in the industry. We are hoping this information will help you become a professional driver faster than if you didn't know about many of these topics. Are you enjoying the show? If so we would appreciate you leaving us a rating and review on your favourite podcast platform. www.theleadpedalpodcast.com Join The Lead Pedal Fan Club where are loyal fans get first chance at specials, discounts on merchandise and much more.The club is free to join and you can learn more at www.theleadpedalfanclub.com LISTEN TO LEAD PEDAL RADIO with music and entertainment with a trucking theme at www.LeadPedalRadio.com
Only a few days after winning Challenge Roth and shocking the triathlon world by beating Lucy Charles-Barclay & Kat Matthews to do so, Alanis Siffert joins us to talk all about HOW she did it. We get stuck right into the training she did leading into the race where Alanis gives us so many details we could all literally just copy her program. But I warn you, it's a pretty crazy training program that not many people in the world could survive (like her huge double bike and double run days, for example). I get the scoop on her 4 month training camp in China where her life was nothing but eat, sleep, train, repeat and ask all about what China is really like as a training camp environment and to make it a bit less mysterious for us all. There's lots of other amazing stuff in here about mindset and trying to train harder than the rest of the world, diet, body weight and we also get a step by step recounting of the Challenge Roth race and stories from Alanis that you won't have heard anywhere else yet. Try NOMIO for yourself. Discount code - TTH15 (for 15% off). In Europe - https://drinknomio.com In America - go to thefeed.com and search “Nomio” In Australia - go to aidstation.com.au and search “Nomio” Precision Fuel & Hydration: Use the code TTH15 to get 15% off your first order with Precision at their website. We would LOVE if you could tell Precision you heard about them from The Triathlon Hour in their "how did you hear about us?" question when purchasing - it helps support the podcast. Lever Movement: Use the massive discount code TTH for 20% off your Lever system, just google "Lever Movement" to find their website.
For review:1. Iran's slain supreme leader ayatollah Ali Khamenei was buried in the country's holiest shrine, state media said early on Friday. The burial in Mashhad in northeast Iran follows a week of mass funeral processions, rallies and mourning.2. The United States is demanding that Iran publicly state it will stop attacks on ships in the Strait of Hormuz and that all lanes in the strait will be open to shipping with no tolls, senior US officials say.3. US President Donald Trump said Friday that the US has agreed to continue holding talks with Iran, but reiterated that the ceasefire with Tehran is over.4. Iran fired missiles into Jordan as it targeted US military infrastructure across the Middle East after the American military carried out another wave of strikes on Iran, including attacks that Iran said hit near the perimeter area of the Bushehr nuclear plant.5. A series of unclaimed airstrikes that hit Iran after the US said it finished its attacks have again raised questions of who else may be targeting the Islamic Republic.6. Prime Minister Benjamin Netanyahu, Defense Minister Israel Katz, and IDF Chief of Staff Lt. Gen. Eyal Zamir all declared on Thursday that Israel would be ready to return to war with Iran at a moment's notice.7. Turkish President Recep Tayyip Erdogan on Wednesday dismissed objections from Israel and Greece concerning the possible US sale of F-35 fighter jets to Turkey.8. Lockheed Martin and Rheinmetall have signed an agreement to co-produce the U.S. Army Tactical Missile System (ATACMS) at Rheinmetall's Unterlüß site in northern Germany, marking the first time the ballistic missile is set to be manufactured outside the United States.9. The United Kingdom announced today it planned to join the US Army's Precision Strike Missile (PrSM) program after having set aside £190 million ($254 million) to buy the long-range munitions.
This week Jay sits down with Jaden from West Elk Precision to nerd out on all things custom rifles, precision shooting, and long-range hunting. Jaden shares his journey from a Colorado kid hunting with a factory Remington 700 to attending gunsmithing school and launching his own custom rifle shop focused on the rapidly growing pre-fit barrel market. They dive deep into the philosophy of building the perfect hybrid hunting/competition rifle, the rise of the 25 Creedmoor, and why negative comb stocks are going to change the way hunters shoot. Jay also shares his controversial take on why you should never buy a mid-tier spotting scope, and they discuss how shooting NRL Hunter matches with heavy gear can actually make you more lethal in the backcountry. Whether you're looking to upgrade your factory Tikka with a pre-fit barrel, trying to figure out barrel break-in procedures, or just want to know how to build a better shooting position using a tripod as a rear rest, this episode is packed with actionable advice for the precision-minded hunter.
You know the feeling. Time bends. The work moves through you rather than from you. Self-consciousness drops away and something quieter, more capable, takes over. Psychologist Mihaly Csikszentmihalyi called it flow. Neuroscientists call it transient hypofrontality. Athletes call it the zone. Whatever name you use, the experience is unmistakable, and the brain state behind it is measurable: elevated alpha and theta waves, a quieting of the prefrontal cortex, and a whole-brain integration that most of us can access only occasionally, and rarely on demand.This Vibe Drop is built to change that.Crystal singing bowls tuned to 432 Hz carry a note progression drawn from the creativity and motivation protocols of precision sound therapy, with intervals selected for their documented effects on the autonomic nervous system, cognitive activation, and the release of nitric oxide and endogenous opiates that accompany deep harmonic resonance. Himalayan singing bowls add warmth and support heart rate variability, creating the physiological calm the body needs to allow focus to deepen rather than strain. Beneath all of it, a continuous 40 Hz gamma isochronic pulse anchors the session neurologically, the same frequency range identified in landmark research at MIT as a driver of neural integration, cognitive resilience, and long-term brain health.This is not background music. It is a precisely composed neuroacoustic environment, designed with the same rigor we bring to everything in the Restorative Audio catalog.Put on headphones. Set an intention. Let the sound take you in.Restorative Audio by Vibes AI. Precision frequency medicine.Send us Fan MailSupport the show
You know the feeling. Time bends. The work moves through you rather than from you. Self-consciousness drops away and something quieter, more capable, takes over. Psychologist Mihaly Csikszentmihalyi called it flow. Neuroscientists call it transient hypofrontality. Athletes call it the zone. Whatever name you use, the experience is unmistakable, and the brain state behind it is measurable: elevated alpha and theta waves, a quieting of the prefrontal cortex, and a whole-brain integration that most of us can access only occasionally, and rarely on demand.This Vibe Drop is built to change that.Crystal singing bowls tuned to 432 Hz carry a note progression drawn from the creativity and motivation protocols of precision sound therapy, with intervals selected for their documented effects on the autonomic nervous system, cognitive activation, and the release of nitric oxide and endogenous opiates that accompany deep harmonic resonance. Himalayan singing bowls add warmth and support heart rate variability, creating the physiological calm the body needs to allow focus to deepen rather than strain. Beneath all of it, a continuous 40 Hz gamma isochronic pulse anchors the session neurologically, the same frequency range identified in landmark research at MIT as a driver of neural integration, cognitive resilience, and long-term brain health.This is not background music. It is a precisely composed neuroacoustic environment, designed with the same rigor we bring to everything in the Restorative Audio catalog.Put on headphones. Set an intention. Let the sound take you in.Restorative Audio by Vibes AI. Precision frequency medicine.Send us Fan MailSupport the show
What if you didn't need 10,000 steps or a gym membership to get the benefits of exercise? Recent studies show that brief bursts of vigorous activity…woven naturally into daily life…can substantially reduce your risk of heart disease and cancer.One of the key researchers behind these studies, Professor Emmanuel (Manos) Stamatakis, joins us to share the key findings. His message? You have more control over your health than you think.What You'll Discover In This Episode 00:00 – How your health transforms with daily micro changes06:00 – VILPA: how ‘brief bursts of activity' could save your life08:00 – Just a few minutes of intense everyday movement cuts disease risk12:00 – Forget perfect workouts, every single minute of movement counts18:00 – The first few minutes of exercise matter more than you think26:00 – Why Professor Emmanuel got rid of his car40:00 – Hate the gym? Turn daily tasks into powerful workoutsAbout Emmanuel (Manos) StamatakisProfessor of physical activity, lifestyle and population health at Monash's Turner Institute for Brain and Mental Health. 450 peer-reviewed publications and >55K citations rank him among the top 0.1% of cited researchers globally since 2019. He served as co-Chair of the World Health Organization's Physical Activity and Sedentary Behaviour Guidelines Development Group in 2020. He has initiated and leads major programs investigating the health impacts of physical activity, sleep, and sedentary behaviour across large cohort studies and international wearable-data consortia, including the ProPASS consortium. Connect with Professor Stamatakis on LinkedIn.About Your HostHosted by Dr. Deepa Grandon, MD, MBA, a triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidence-based lifestyle medicine.Work with Me - Learn More About My Soon-to-Launch Telemedicine PlatformExciting news—my virtual medical platform is launching soon! If you're looking for personalized, evidence-based care in allergy, immunology, and lifestyle medicine, stay tuned. Click here to join the wait-list and be the first to receive updates about services, membership options, and launch details.Precision care. Personalized guidance. Wherever you are.Feeling stuck and want guidance on how to transform your spiritual, mental and physical well being? Get access to Dr Deepa's 6 Pillars of Health video! Subscribe and watch the video for free here.Want to receive a devotional every week From Dr. Deepa? Devotionals are dedicated to providing you with a moment of reflection, inspiration, and spiritual growth each week, delivered right to your inbox. Subscribe now.Ready to deepen your understanding of trauma and kick start your healing journey? Explore a range of online and onsite courses designed to equip you with practical and affordable tools. From counselors, ministry leaders, and educators to couples, parents and individuals seeking help for themselves, there's a powerful course for everyone. Browse all the courses now to start your journey.DisclaimerTLC is presenting this podcast as a form of information sharing only. It is not medical advice or intended to replace the judgment of a licensed physician. TLC is not responsible for any claims related to procedures, professionals, products, or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services, or methods that might be referenced.
Join Sundeep Ahluwalia, Chief Product Officer at TDK SensEI, as he explores the future of industrial manufacturing and computer vision. In this webinar, Sundeep introduces edgeRX Vision—a powerful combination of computer vision and edge AI designed to deliver fast, accurate quality control directly on the production line. Currently deployed in TDK manufacturing facilities worldwide, edgeRX Vision can inspect up to 2,000 parts per minute, detecting defects in components as small as 1 mm × 0.5 mm. Discover how edgeRX Vision enables manufacturers to achieve: Enhanced AOI capabilities Higher production throughput Real-time visual feedback Precision driven by AI Reduced human error PRESENTER: Sundeep Ahluwalia Chief Product Officer Presented by TDK SensEI Visit https://advancedmanufacturing.org/webinars for more webinars and an interactive experience with visuals.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/TPJ865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 29, 2027.Therapeutic Progress and IMPACT in CRC: Expert Guidance on Applying Rapidly Emerging Evidence on Immunotherapy and Molecular, Precision-Based Approaches in CRC Treatment In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Colorectal Cancer Alliance. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported through medical education grants from Bristol Myers Squibb, Exelixis, Inc., Johnson & Johnson, and Taiho Oncology, Inc.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/UHM865. CME/MOC/AAPA/IPCE credit will be available until June 29, 2027.Riding the ADC Wave Into Gynecologic Cancer Care: Evidence, Safety, and Precision Strategies[JAC_Logo] In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Foundation for Women's Cancer. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through independent educational grants from AstraZeneca, Daiichi Sankyo, Inc., and Merck & Co., Inc., Rahway, NJ, USA.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/UHM865. CME/MOC/AAPA/IPCE credit will be available until June 29, 2027.Riding the ADC Wave Into Gynecologic Cancer Care: Evidence, Safety, and Precision Strategies[JAC_Logo] In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Foundation for Women's Cancer. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through independent educational grants from AstraZeneca, Daiichi Sankyo, Inc., and Merck & Co., Inc., Rahway, NJ, USA.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/TPJ865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 29, 2027.Therapeutic Progress and IMPACT in CRC: Expert Guidance on Applying Rapidly Emerging Evidence on Immunotherapy and Molecular, Precision-Based Approaches in CRC Treatment In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Colorectal Cancer Alliance. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported through medical education grants from Bristol Myers Squibb, Exelixis, Inc., Johnson & Johnson, and Taiho Oncology, Inc.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/TPJ865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 29, 2027.Therapeutic Progress and IMPACT in CRC: Expert Guidance on Applying Rapidly Emerging Evidence on Immunotherapy and Molecular, Precision-Based Approaches in CRC Treatment In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Colorectal Cancer Alliance. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported through medical education grants from Bristol Myers Squibb, Exelixis, Inc., Johnson & Johnson, and Taiho Oncology, Inc.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/UHM865. CME/MOC/AAPA/IPCE credit will be available until June 29, 2027.Riding the ADC Wave Into Gynecologic Cancer Care: Evidence, Safety, and Precision Strategies[JAC_Logo] In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Foundation for Women's Cancer. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through independent educational grants from AstraZeneca, Daiichi Sankyo, Inc., and Merck & Co., Inc., Rahway, NJ, USA.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/TPJ865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 29, 2027.Therapeutic Progress and IMPACT in CRC: Expert Guidance on Applying Rapidly Emerging Evidence on Immunotherapy and Molecular, Precision-Based Approaches in CRC Treatment In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Colorectal Cancer Alliance. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported through medical education grants from Bristol Myers Squibb, Exelixis, Inc., Johnson & Johnson, and Taiho Oncology, Inc.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/UHM865. CME/MOC/AAPA/IPCE credit will be available until June 29, 2027.Riding the ADC Wave Into Gynecologic Cancer Care: Evidence, Safety, and Precision Strategies[JAC_Logo] In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Foundation for Women's Cancer. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through independent educational grants from AstraZeneca, Daiichi Sankyo, Inc., and Merck & Co., Inc., Rahway, NJ, USA.Disclosure information is available at the beginning of the video presentation.
Highlights from the PER® CME activity "Medical Crossfire®: Precision Oncology in NSCLC – Translating HER2 and TROP2 Innovation into Practice-Changing Care" — this podcast is not certified for credit. To participate in the full accredited activity and earn CME credit, use the link below.In this podcast, focusing on precision oncology in non-small cell lung cancer (NSCLC), experts Helena Yu, MD; Jacob Sands, MD; and Sarah Goldberg MD, MPH; will discuss the rapidly evolving landscape of Human Epidermal growth factor Receptor 2 (HER2)- and Trophoblast cell-surface antigen 2 (TROP2)-directed therapies in NSCLC. The podcast covers the spectrum of targeted agents from antibody-drug conjugates (ADCs) to novel HER2-selective tyrosine kinase inhibitors (TKIs), along with key clinical trial data and practical strategies for managing the unique adverse event profiles associated with these treatments.Earn CME credit by completing the full accredited activity (available through June 30, 2027): https://www.gotoper.com/courses/medical-crossfire-precision-oncology-in-nsclc-translating-her2-and-trop2-innovation-into-practice-changing-care-mr5qThis podcast, including the narration, was developed by PER® (Physicians' Education Resource®, LLC) editorial staff from the full online CME activity developed with these faculty. The narration was voiced by a PER staff member or by an AI tool. The podcast contains no product advertising. The full activity is supported by educational grants from AstraZeneca Pharmaceuticals; Daiichi Sankyo, Inc.; and Gilead Sciences, Inc.This content is for educational purposes only and is not a substitute for the independent clinical judgment of a health care professional. Faculty may discuss investigational or off-label uses; consult prescribing information for any products discussed.
Wow. Challenge Roth was everything. From Sam Laidlow's dominate win against Kristian Blummenfelt to the biggest upset win of the year in the women's race by Alanis Siffert over Lucy Charles-Barcly this years race seriously had it all. So, whether you watched it and want to relive it or you missed it and need us to catch you up - we've got you! Try NOMIO for yourself. Discount code - TTH15 (for 15% off). In Europe - https://drinknomio.com In America - go to thefeed.com and search “Nomio” In Australia - go to aidstation.com.au and search “Nomio” Precision Fuel & Hydration: Use the code TTH15 to get 15% off your first order with Precision at their website. We would LOVE if you could tell Precision you heard about them from The Triathlon Hour in their "how did you hear about us?" question when purchasing - it helps support the podcast. Lever Movement: Use the massive discount code TTH for 20% off your Lever system, just google "Lever Movement" to find their website. Nerd Belts Discount code - TTH26 (for 15% off) Click here to buy yourself a Nerd Belt
Send us Fan MailCarli Kistler-Miller, Harry Centa, and David Wynn discuss what they wish more customers understood about the precision machining industry. In this episode, they explore how customer choices such as part design, material selection, tolerances, and lead-time expectations can have a major impact on cost, manufacturability, quality, and delivery.For More Information Visit pmpa.org/podcasts
This week we talk about: Zoho CRM: Add Agents To Your Homepage Zoho CRM: Related List Expanded View Zoho Creator: Advanced Metrics for App Engagement Analytics Our Code Share, Read, Tip and Question of the Week Read the show notes: https://zenatta.com/episode-413/ ⚖️ Avalara AvaTax for Zoho CRM ⚖️ Accurate Tax. Zero Guesswork.
Welcome to the Celestial Insights Podcast, the show that brings the stars down to Earth! Each week, astrologer, coach, and intuitive Celeste Brooks of Astrology by Celeste will be your guide. Her website is astrologybyceleste.com.
What happens when an evolutionary biologist and an aerospace engineer both arrive at the same conclusion — that the future of drug manufacturing isn't steel, it's biology? In this episode, Karl Schmieder and Erum Azeez Khan sit down with Sam Levin (Co-Founder & CTO) and Dimi Kellari (Co-Founder & CEO) of Neion Bio to unpack one of the most counterintuitive ideas in modern biomanufacturing: producing therapeutic medicines inside genetically engineered chicken eggs. Rather than optimizing the same mammalian cell culture systems that have defined biopharma for 50 years, Neion Bio's Raptor platform replaces complex steel bioreactor infrastructure with a self-replicating, two-input biological system — chicken feed and water in, life-saving medicines out. The conversation covers their stealth-to-commercial journey, a multi-product monoclonal antibody partnership announced alongside $11M in seed funding, the scalability and supply chain resilience advantages of egg-based manufacturing, how they navigate FDA regulation with a living bioreactor, and their North Star: dropping end-to-end production costs of monoclonal antibodies below $10 per gram — an order of magnitude that could fundamentally reshape who has access to biologics and where they're made.Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing?Learn more at www.messaginglab.com/groweverythingChapters:(00:00:00) - Intro & 4th of July: America's 250th anniversary celebrations(00:03:00) - America's Living Library Act & NDAA biotech provisions(00:06:00) - Midjourney's ultrasonic body scanner & patient data ownership(00:10:00) - NVIDIA's AI co-scientist, the AI value pyramid & AbbVie's $11B Apogee acquisition(00:20:00) - Introducing Sam Levin & Dimi Kellari of Neion Bio(00:26:00) - Neion Bio's Raptor platform: making medicines inside chicken eggs(00:33:00) - Scalability, onshoring & true supply chain resilience(00:39:00) - Downstream purification: cracking eggs vs. CHO cell lysate(00:47:00) - FDA pathways & batch-to-batch consistency in a living bioreactor(00:50:00) - Drug supply chain fragility & national health security(00:56:00) - $10/gram North Star: end-to-end cost breakdown(01:00:00) - Quickfire Q&A: engineering challenges, union demands & investor misconceptions(01:04:00) - Outro: calls to action & what's next for Neion BioLinks and Resources:Neion BioContact to partner with Neion BioChicken Eggs Become BiorectorsNeion Bio Raises Oversubscribed $23 Million Series A to Advance Biologics Manufacturing Platform and Expand Pipeline183. The American Biotech Blueprint: Senator Todd Young on Biodiversity as National Security186. N.Y. Tech Week Live Demo: Engineering the Future of Manufacturing with Roebling's Brentan Alexander170. There's a Bug for That: Sophia Xu on CarbonBridge's Notebook Bioreactors176. Dare to Commercialize: Damien Perriman's eXoZymes PlaybookNVIDIA announces BioNeMoA.I. Value Pyramid - Murat AktihanogluAbbVie to acquire Apogee for $11BGrow everything LinkedInBioInnovations Events - For 25% off use code: Grow EverythingTopics Covered:chickens, eggs, biomanufacturing, therapeutic medicines, CHO cells, monoclonal antibodies, supply chain, biosimilars, Raptor, national health securityHave a question or comment? Message us here:Text or Call (804) 505-5553Instagram / Twitter / LinkedIn / Youtube / Grow EverythingMusic by: Nihilore Production by: Amplafy Media
Many stalled deals do not fail because the solution is weak. They fail because the team moved too fast before the buyer had a reason to care, a sponsor willing to mobilize, and enough confidence to take the risk. Randy Riemersma joins John McMahon and John Kaplan to unpack how false velocity, shallow discovery, and weak executive alignment create fragile opportunities that collapse late. He explains why elite sellers slow down early, uncover real business pain, connect operational problems to strategic outcomes, and manage the emotional side of buying when the decision starts to feel personal. Randy Riemersma is the founder of Sell with Precision, where he helps sales leaders strengthen go-to-market execution, leadership effectiveness, and sales operating discipline. He has spent decades in B2B sales, leadership, consulting, and executive coaching, with a focus on helping teams sell with greater clarity, precision, and business relevance. Connect with Randy: LinkedIn Website Resources mentioned: The Happiness Lab with Dr. Laurie Santos - The Hidden Beliefs That Shape Your Happiness with Shawn Achor Key takeaways from this episode: 00:00 - Why many late-stage deals are lost long after the buyer has agreed with the business case. 02:37 - What leaders often overlook when early deal momentum feels too good to be true. 03:51 - A look inside the moment elite sellers create the urgency that average reps never uncover. 12:53 - Why many CROs see strong operational engagement fail to translate into executive sponsorship. 16:41 - The six emotions that drive buyer decisions and how to leverage them across deal stages. 28:24 - What it really takes to build buyer belief when the risk of saying yes starts to feel personal. 40:28 - Why the best discovery conversations feel less like qualification and more like understanding. Hosted by five-time CRO John McMahon and Force Management Co-Founder John Kaplan, the Revenue Builders podcast goes behind the scenes with the sales leaders who have been there, done that, and seen the results. This show is brought to you by Force Management. We help companies improve sales performance, executing their growth strategy at the point of sale. Connect with Us: LinkedInYouTubeForce Management
The cell and gene therapy industry faces massive hurdles—cost, scalability, and the need for highly skilled operators have historically limited the reach of these transformative treatments. advanced therapy medicinal products manufacturing innovation is urgently needed to overcome these challenges and unlock broader global access.Farlan Veraitch, founder and Chief Scientific Officer at Ori Biotech, is leading the way in reimagining manufacturing platforms using automation, modularity, and digital transformation. His vision is redefining how cell and gene therapies are produced—from research labs to point-of-care hospital settings.What's inside:The use and adaptation of the paper pull tab sterile connection system—miniaturized and multiplexed—to ensure reliable material transfer in the manufacturing process (06:36)How modular and stackable system design supports scale-up and scale-out, increasing manufacturing capacity and flexibility (09:17)Full digitization of the Ori platform, including setting up digital twins, integrating sample prep automation, and capturing data for QA/QC in real time (10:11)Deskilling bioprocess operations, reducing the need for highly trained cell culture staff, and enabling broader use in both centralized facilities and hospitals (14:02)The logistical benefits of separating material prep (like buffer and virus formulation) from the manufacturing site to streamline point-of-care applications (15:39)Farlan's vision for an accessible, profitable, globally distributed manufacturing platform to support new treatment pipelines (17:14)Driving down cost and improving scalability as key challenges to unlocking the potential of cell and gene therapies (18:49)Strategic insight:The cell and gene therapy field needs to lower manufacturing costs and increase production. Focused, practical approaches are required to make these life-changing therapies more efficient, scalable, and accessible to more patients around the world.Listen for practical perspectives on automation, digital tools, manufacturing infrastructure, and the future possibilities for decentralized, scalable cell and gene therapy production.Connect with Farlan Veraitch:LinkedIn: www.linkedin.com/in/farlan-singh-veraitch-a677112Email: farlan.veraitch@oribiotech.comOri Biotech: www.oribiotech.comNext step:Need fast CMC guidance? → Get rapid CMC decision support hereSupport the show
SHOW NOTES In this episode, Jon and I discussed: How his experience in NASCAR shaped the way he approaches precision, pressure, troubleshooting, and entrepreneurship in the integration world. Why professional design documentation, outsourced engineering partnerships, and strong project planning are critical. And how Jon is building Fusion Automation through relationships with architects, designers, and builders, while leaning into high-growth categories like lighting, shades, invisible audio, and digital displays. Whether you're interested in building stronger relationships with architects and designers, growing a design-forward integration firm, or hearing how lessons from NASCAR translate into business ownership, you're going to enjoy this conversation. So settle in and enjoy my conversation with Jonathan Smith. Let's get started! To get transcripts, resources of what was mentioned in the show, and more visit the podcast page on our website at onefirefly.com/au360
Precision in practice. Trust on the course. That's the theme this week — and Viktor Hovland just proved it in the most dramatic way possible.Episode 128 is here, and Scott's breaking down one of the wildest weekends we've seen in a while. The Travelers Championship — the last $20M Signature Event of the year — couldn't even finish on Sunday. Scheffler and Hovland finished tied at 21-under after an 83-minute rain delay blew the whole thing wide open, with Hovland roaring back with three straight birdies to force a Monday playoff. He closed it out on No. 18 the next morning — his first win since last year's Valspar — and we've got the full story of how he got there.Over on the LPGA side, the KPMG Women's PGA Championship at Hazeltine brought its own Sunday drama, with Haeran Ryu holding off a hard-charging field and Nelly Korda chasing a third straight major. And on the DP World Tour, Eugenio Chacarra birdied the 72nd hole to steal the KLM Open by a single shot. Different tours, same story all week: the player who trusted their game in the clutch walked away with the trophy.That's exactly what this week's improvement segment is about — precision in practice is what lets you trust it when you play. Hovland didn't claw his way back by gritting his teeth and trying harder. He bogeyed four of his first ten holes, used that rain delay to reset, and came out firing three straight birdies — because the mechanics were already in there. That's not luck, that's reps. That's what it means to Own Your SSWING —Scott breaks down what that means for your own game, and why what you do between rounds is what shows up when it counts.Join the SSWING SocietyBe part of a growing community of golfers, movers and performance-minded individuals committed to mastering their game.
Troy Wilson, CEO of San Diego-based Kura Oncology, on his career in biotech and developing targeted cancer drugs.
Welcome back to the Pear Healthcare Playbook! Today we're thrilled to host Ron Alfa, co-founder and CEO of Noetik. Noetik is building an AI-native platform for cancer biology, generating large-scale human data to train biological foundation models that both predict patient responses to therapy and uncover new drug targets and treatment opportunities. Most recently, Noetik signed a $50 million licensing agreement with GSK, giving GSK access to Noetik's virtual cell foundation models, along with one of the largest multimodal spatial oncology datasets assembled to date. In this episode, we discuss Ron's journey to founding Noetik, why building truly useful models of biology requires large-scale, multimodal human data, and how biological foundation models can transform precision oncology. We also explore what it takes to build an AI-native biotech company, lessons from partnering with pharma, the future of drug discovery, and the path toward bringing more personalized cancer treatment to every patient.
What if the simple act of opening an incubator could undermine the consistency of your cell therapy manufacturing process? Unlike traditional biologics, the moment cells leave their incubator, subtle shifts in temperature, CO₂, and pH can spiral into mission-critical variability, jeopardizing everything from product yield to therapeutic potency.This episode features Farlan Veraitch, founder and Chief Scientific Officer of Ori Biotech. Trained at UCL's Department of Biochemical Engineering, Farlan blends a bioprocess engineer's mindset with hands-on experience scaling monoclonal antibodies, before pioneering the first-ever automation platform for embryonic stem cell culture. His drive for eliminating variability and designing systems that scale seamlessly from bench to bedside has informed ORI's approach to modular cell therapy manufacturing.What you'll hear in this episode:The importance of controlling pH, temperature, and shear forces in cell therapy manufacturing (00:36)Lessons learned from scaling monoclonal antibody production and its impact on biotech business models (05:23)The unique sources of variability in primary and stem cells, and why automation is essential (11:16)Strategies to minimize human-induced variability in sensitive cell cultures (12:59)How exposure to ambient oxygen and CO₂ during manual processing affects cell viability (14:13)The logic behind Ori Biotech's modular design to solve environmental control issues (19:04)Strategic insight:As cell and gene therapies push boundaries, manufacturing must keep pace with exponentially tighter requirements. Farlan's journey highlights a universal lesson for scientists and engineers: process control is not just a technicality, but a necessity for reproducible, scalable, and commercially viable therapies.If you're grappling with process variability or looking for fresh strategies in cell and gene therapy development, this episode offers an inside view from a scientist who's worked at the intersection of bioprocess, automation, and commercial translation.Connect with Farlan Veraitch:LinkedIn: www.linkedin.com/in/farlan-singh-veraitch-a677112Email: farlan.veraitch@oribiotech.comOri Biotech: www.oribiotech.comNext step:Need fast CMC guidance? → Get rapid CMC decision support hereSupport the show
This episode's Community Champion Sponsor is Ossur. To learn more about their ‘Responsible for Tomorrow' Sustainability Campaign, and how you can get involved: CLICK HEREEpisode Overview: Precision diagnostics and precision care are not two separate steps. They are a single, continuous system, and treating them otherwise is costing health plans time, money, and patient outcomes.Dr. Bill Kerr, Co-Founder and CEO of Avalon Healthcare Solutions, has spent over a decade building the infrastructure to close that gap.With a career spanning chief medical officer roles at WellCare Health Plans and Blue Cross Blue Shield of Florida, Bill brings rare fluency across clinical science, health plan economics, and operational complexity.Through Avalon's Diagnostic Insights Platform, his team is ensuring the right test reaches the right patient at the right time, driving smarter decisions and reducing costly waste across millions of members nationwide.Join us to discover how precision diagnostics are reshaping the future of value-based care. Let's go!Episode Highlights:Dr. Kerr founded Avalon to accelerate lab science adoption, closing the costly 20-year gap between discovery and clinical use.Lab testing is only 10% of medical spend, but drives 70% of clinical decisions, making diagnostic precision essential.In non-small cell lung cancer, only one-third of patients currently receive best-in-class, mutation-targeted treatment.Avalon now serves 30 health plans and roughly 100 million lives, expanding into diagnostic imaging with AI integration.Dr. Kerr's ask to the community: help Avalon bring diagnostic insights into the exam room without adding clinical noise.About our Guest:Before co-founding Avalon, Dr. Kerr served as the Chief Medical and Growth Officer atCareCentrix, a company focused on delivering healthcare at home. Prior to joiningCareCentrix, Dr. Kerr served as the Chief Medical Officer at WellCare Health Plans andBlue Cross Blue Shield of Florida. Dr. Kerr was previously the Vice President ofProfessional Networks at Independence Blue Cross and regional medical director forseveral plans in Texas.Dr. Kerr holds a BA from the University of Arkansas, an MBA from the University of Houston, and an MD from the University of Arkansas. He was also a research associate in the Nuffield Department of Pathology at the University of Oxford.Links Supporting This Episode: Avalon Healthcare Solution website: CLICK HEREDr. Bill Kerr LinkedIn page: CLICK HEREAvalon Healthcare Solutions LinkedIn page: CLICK HEREMike Biselli LinkedIn page: CLICK HEREMike Biselli Twitter page: CLICK HEREVisit our website: CLICK HERESubscribe to newsletter: CLICK HEREGuest nomination form: CLICK HERE
What if your next big business breakthrough started with owning your own blind spots?This Fan Favorite episode throws you in the trenches with Cameron Herold and SaaS Academy's former COO and current CEO Matt Verlachi, as they go far beyond surface-level business banter. From surviving firefighting chaos to building, selling, and now scaling SaaS Academy, Matt Verlachi exposes the real skills that make or break Second in Commands. They unpack why customer obsession cures more growth headaches than any software, how to weaponize one-on-ones for radical team development, and what most COOs get dead wrong about CEO dynamics.Miss this? You risk coasting on old habits while others engineer unfair advantages. Listen now for hard-won tactics you won't find in any business course from the world's largest SaaS coaching engine. Timestamped Highlights00:45 – The firefighting mindset that built decisive business instincts05:56 – The overlooked power of “small unit” teams to unlock real growth09:44 – Are you a COO trapped in a CEO's title? The unexpected identity test13:43 – Brutal truths about customer obsession and why most leaders fail here16:18 – The lesson no founder learns soon enough when selling their company18:22 – The surprising reason joining SaaS Academy changed his life21:31 – The founder's hidden block: How self-worth destroys pricing27:31 – The counterintuitive leadership split that 10x'd their decision speed41:07 – How his “full-person” one-on-ones rip open performance breakthroughs About the GuestMatt Verlaque was the former COO of SaaS Academy (now Precision), steering operational strategy for the largest coaching platform serving B2B SaaS entrepreneurs. With first-hand experience ranging from firefighting to founding and selling a SaaS startup, he delivers operating wisdom forged under real pressure. He is currently serving as the CEO at Precision, where they help growth-minded founders understand how their business actually works so they can scale with clarity, not chaos.