Podcasts about sens research foundation

Matthew "Oki" O'Connor is the CEO of Scientific Affairs at Cyclarity Therapeutics, a clinical-stage biotech building a new class of medicines designed not to slow the accumulation of vascular damage but to reverse it. Oki and Chris first crossed paths as postdocs at Lawrence Berkeley National Lab in the mid-2000s — Oki was in Irina Conboy's lab, not far from the late Judy Campisi's group, where Chris was then working on cellular senescence. After Berkeley, Oki spent nearly a decade running the research program at the SENS Research Foundation, the organization most identified with the "damage repair" framing of aging biology, before co-founding Cyclarity (then known as Underdog Pharmaceuticals) in 2019 to translate one of SENS's most drug-tractable ideas into an actual molecule.When Oki was last on the show in March of 2023 (Episode 36), Cyclarity was deep in IND-enabling work and its lead asset, UDP-003, had only ever seen the inside of a mouse artery. At the end of that conversation, Chris asked what Oki hoped to be discussing the next time he visited. He answered, bluntly, that he wanted to be presenting human data. Last month, at the AHA Vascular Discovery Sessions, Cyclarity reported the results of their first-in-human Phase 1 trial of UDP-003 — a designed cyclodextrin that selectively binds 7-ketocholesterol, the oxidized cholesterol species that drives foam cell formation and arterial plaque. He's back to discuss what the drug actually did when it went hunting for 7KC inside a living human being.In this episode, Chris and Oki cover the unmet need that lipid-lowering drugs — statins, PCSK9 inhibitors, the coming Lp(a) agents — still don't address: none of them remove the damage already sitting in an artery wall. Oki explains the basic chemistry of 7-ketocholesterol and why macrophages, lacking the machinery to recycle it, collapse into foam cells and seed the necrotic core of advanced plaque. They walk through the engineering of UDP-003 as a dimeric beta-cyclodextrin "double cone" tuned for a single oxidized cholesterol species, the design of the 72-volunteer Australian Phase 1, and the exploratory pharmacodynamic readout that has the field's attention: dose-dependent urinary excretion of 7KC, stoichiometric with drug, cleared within a day. The conversation then turns to the 150-patient Phase 2 plan in coronary artery disease patients with plaque imaging as the primary biological readout, the funding math that stands between Cyclarity and that trial, the platform's reach into NASH, vascular dementia, AMD, and aging itself, and how all of this descends from the SENS damage-repair philosophy that Oki has been carrying since LBL.The Finer Details:- Why current standard of care is not enough — statins, PCSK9 inhibitors, GLP-1s, and the soon-to-arrive Lp(a) lowering agents all act by slowing the accumulation of arterial damage, not by reversing what's already there; despite 30 years on the market, statins have never demonstrated an all-cause mortality benefit in a clinical trial, and even the best statin imaging data shows only 1–2% plaque volume regression at very high doses in a subset of patients- The scale of the problem — atherosclerosis is estimated to contribute to roughly 40% of all human deaths once heart attack, stroke, and a surprisingly large COPD contribution are risk-adjusted in, on top of an enormous morbidity tail that includes angina, peripheral artery disease (up to and including amputation), and a growing case for vascular dementia as an undercounted driver of cognitive decline- The biology of 7-ketocholesterol — when an oxygen free radical reacts with cholesterol, it preferentially attacks the 7 position, and a second oxidation step locks the molecule into 7KC, a stable toxic species cells were essentially never equipped to recycle; it builds up in long-lived cells like macrophages, eventually shutting down their ability to traffic lipids back to the liver via HDL and converting them into foam cells that seed soft plaque and, over years, the necrotic core of advanced lesions- The molecular design of UDP-003 — cyclodextrins are naturally occurring carbohydrate rings; the beta size fits half a cholesterol molecule, and Cyclarity's in silico work showed that two beta-cyclodextrins facing wide-side to wide-side form a "double cone" that can fully encapsulate a single cholesterol; engineered correctly, that wrapper can be made selective for 7KC over native membrane cholesterol, which is what gives the drug its therapeutic window- The Phase 1 trial design and result — a traditional 72-volunteer safety study in Australia, split between single ascending dose and multiple ascending dose arms, escalating up to six doses at what Cyclarity believes will be the efficacious level; no serious adverse events, no bioaccumulation, drug excreted essentially completely in the urine (as predicted preclinically), and — the headline exploratory endpoint — dose-dependent urinary 7-ketocholesterol appearing on the same timescale as the drug, consistent with one molecule of UDP-003 binding one molecule of 7KC and leaving the body together- What the urinary 7KC readout can and cannot tell you — the easiest 7KC to mobilize is the free pool in circulation, but there is not nearly enough of it floating in the bloodstream to account for what came out in urine, which means the drug is reaching deeper compartments; how much is coming from vessel wall plaque versus liver versus other peripheral tissues will require the imaging endpoints of Phase 2 to answer- The Phase 2 plan — 150 coronary artery disease patients (the coronary being, as Oki puts it, the artery most likely to kill you), with baseline plaque imaging, a year of dosing, and a repeat scan; safety and PK continue, inflammatory biomarkers come on, and plaque volume change is the prize — for context, a 1% change in plaque volume is associated with roughly a 20% change in next-year risk of heart attack or stroke- The funding math and the platform — Cyclarity has raised $33M to date and needs roughly $45M more to run the Phase 2, with Phase 3 cardiovascular outcomes trials running into the hundreds of millions and likely requiring a pharma partner; beyond atherosclerosis, 7KC is elevated in NASH livers, in Alzheimer's brains, and in the retinal cells that die in age-related macular degeneration, and the underlying chemistry — designed binders that drag a specific toxic molecule out of the body — is meant to generalize into a pipeline against other accumulated damage species, the direct intellectual descendant of the SENS damage-repair programQuotes:"Atherosclerosis, or the plaque that builds up in your blood vessels in your arteries, is estimated to cause approximately 40% of all human death.""When [the macrophage] eats up too much oxidized cholesterol, it just accumulates it… And that's when you get this transition to these kind of monster blob cells called foam cells.""One molecule of our drug is supposed to bind one molecule of 7-ketocholesterol and then go away and never be seen again. You excrete both of them together.""A 1% change in plaque volume is associated with a 20% risk in the next year of your probability of having a heart attack or a stroke.""You pick one target at a time, you do it well, and you take it all the way to the clinic and hopefully prove that you can actually cure patients, help them get better, help their plaque shrink away, and prove that this approach can work."Links:Cyclarity Therapeutics: https://cyclarity.com

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away from traditional classifications of illness, the team breaks down a powerful paradigm shift: chronic disease and aging are not separate processes—chronic disease is aging. Drawing from the pioneering frameworks of biogerontologist Aubrey de Grey and the SENS Research Foundation, they discuss how flawed metabolism inherently accumulates structural damage long before a clinical diagnosis ever appears. Join us as we delve into: •The Metabolism Flaw: How the very process keeping us alive produces reactive oxygen species and damage that eventually leads to tissue breakdown and pathology. •Reclassifying Disease: Moving past the old congenital vs. infectious vs. chronic model to target metabolism directly. •The $30,000 Stem Cell Mistake: Why dropping thousands on mesenchymal stem cells (MSCs) or exosomes is a waste of money if your body is trapped in a cellular defense posture. •The Cell Danger Response (CDR): Understanding Robert Naviaux's work on how ancient defense mechanisms shut down growth and repair under stress. •Morbidity Compression: Shifting your biology back to your optimal 21-to-30-year-old baseline to maximize healthspan and ensure you live vibrant before a rapid, peaceful end. This episode is for you if: •You want to understand why biohacking shortcuts like stem cells require metabolic priming to actually work. •You are tired of "normal" lab ranges meant for a sick population and want true, age-optimized biomarkers. •You want to stop guessing what vitamins or antioxidants your body needs and start measuring your exact metabolomic fingerprint. You can also find this episode on… YouTube: https://youtu.be/DygsezbmZxM  Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products 

The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Jim O'Neill served as Deputy Secretary of Health and Human Services and Acting Director of the CDC before being nominated to lead the National Science Foundation in March 2026. Before entering government, he was CEO of SENS Research Foundation, where he led cutting-edge regenerative medicine research targeting mitochondrial mutations, senescent cells, and neocortex rejuvenation. He is a 30-year veteran of health care reform and a genuine longevity insider. Dave and Jim cover the complete rewrite of federal dietary guidelines, the government's new randomized controlled trials on saturated fats, and why grains are no longer the core of a "balanced diet." They dig into a 144 million dollar ARPA H program to establish causal aging biomarkers that will unlock real anti-aging drug development and accelerate the kind of longevity research the SENS Foundation pioneered. Jim explains why current aging clocks and DNA methylation markers are not enough, and what comes next for functional medicine, sleep optimization, and metabolism research. They also break down the CDC's return to its infectious disease core, the future of AI in health care, wearable data for disease surveillance, organ bioprinting, GLP-1s, supplements like vitamin D, peptides, and the right to self-experiment. You will learn: Why the new federal dietary guidelines finally reject grain-centric nutrition and validate what the biohacking world has argued for 25 years How a 144 million dollar government program aims to build the causal biomarkers that will make real anti-aging and longevity drug development possible What Jim thinks about DNA methylation clocks and why better tools are needed to measure aging and human performance How AI is reshaping prescription refills, clinical decision support, Medicare reimbursement, and the future of functional medicine Why Jim wears an Oura Ring and uses sleep optimization data to make daily health decisions The government's evolving stance on peptides, supplements, and therapies that are not patent protected How organ bioprinting using a patient's own cells could solve the organ shortage crisis What real science replication looks like and why the government is now funding it What the CDC is doing to refocus on infectious disease while shedding mission creep How GLP-1s, fitness tracking, and updated nutrition strategies could significantly cut national obesity rates within five years Thank you to our sponsors! - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss with www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - Go to timeline.com/dave and save 20% with code DAVE20 - Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jim O'Neill, CDC, HHS, dietary guidelines, saturated fat, aging biomarkers, ARPA H, SENS Research Foundation, longevity, anti-aging, senescent cells, mitochondria, DNA methylation, sleep optimization, Oura Ring, AI healthcare, organ bioprinting, GLP-1, peptides, vitamin D, supplements, functional medicine, biohacking, Dave Asprey, human performance, metabolism Resources: • Learn more at: https://www.hhs.gov/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:15 – Dietary Guidelines Overhaul 06:48 – Misinformation & Scientific Integrity 10:26 – Longevity vs. Chronic Disease 13:03 – Aging Biomarkers & ARPA-H 14:31 – CDC's Refocus on Infectious Disease 16:55 – Alternative Therapies & Biohacking 19:21 – Health Trackers & Privacy 22:27 – AI in Healthcare 24:01 – Diet, Supplements & School Meals 27:31 – Food Safety, Pesticides & Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

One on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meetingSupport the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USThe Lila Code: https://orcid.org/0009-0008-4612-3942

On this replay preview of Brave New World, Evgeny Lebedev is joined by Dr Aubrey de Grey — a pioneering biomedical gerontologist and co-founder of the SENS Research Foundation.Known for his radical views on ageing, Dr de Grey believes we can and should treat ageing as a medical condition, not an inevitability.In this fascinating conversation, Evgeny and Aubrey explore everything from the ethics of life extension and the science behind reversing cellular damage, to how society might change if ageing becomes optional.Listen to the full conversation on the Brave New World podcast here. Hosted on Acast. See acast.com/privacy for more information.

Evgeny Lebedev joins Dr Aubrey de Grey, a pioneer in biomedical gerontology - the study of life extension and rejuvenation - and co-founder of the SENS Research Foundation.Known for his radical approach to ageing, Dr de Grey discusses his latest research, society's attitude to the human lifespan and his hopes for future anti-ageing treatments. Hosted on Acast. See acast.com/privacy for more information.

Evgeny Lebedev joins Dr Aubrey de Grey, a pioneer in biomedical gerontology - the study of life extension and rejuvenation - and co-founder of the SENS Research Foundation.Known for his radical approach to ageing, Dr de Grey discusses his latest research, society's attitude to the human lifespan and his hopes for future anti-ageing treatments. Hosted on Acast. See acast.com/privacy for more information.

Evgeny Lebedev joins Dr. Aubrey de Grey, a visionary in biomedical gerontology and co-founder of the SENS Research Foundation.Known for his radical approach to ageing, Dr. de Grey discusses why some need to awaken from a "pro-ageing trance".What's Aubrey's biological age?In this episode:Why we don't “have” to ageReversing cellular agingThe ethical questions surrounding life extensionThe societal shifts we might expect if ageing becomes a treatable conditionThe science behind extending the human healthspanPlus more. Hosted on Acast. See acast.com/privacy for more information.

In this episode of the Longevity Optimization Podcast, Dr. DeGray discusses groundbreaking research in aging and longevity, focusing on combination therapies, the hallmarks of aging, and the potential of stem cell and gene therapies. He emphasizes the importance of rejuvenation over merely slowing aging and explores the role of the immune system in health. The conversation also touches on biological age testing, lifestyle factors, and the future of gene therapy in enhancing longevity. Aubrey de Grey is a British biomedical gerontologist and the founder of the SENS Research Foundation. He is a leading advocate for regenerative medicine, focusing on reversing the effects of aging by repairing cellular damage. Known for his bold vision of life extension, de Grey believes that with advanced therapies, humans could significantly extend their lifespan. He is the co-author of Ending Aging, and his work continues to shape the future of longevity science. Takeaways Combination therapies are crucial for understanding aging. Rejuvenation may be easier than slowing down aging. Stem cell therapies hold great promise for the future. The immune system plays a significant role in aging. Biological age testing can provide insights into health. Gene therapy is a promising avenue for longevity research. Lifestyle factors have limited impact on lifespan extension. Understanding the hallmarks of aging is essential for interventions. Preventative maintenance is key to longevity. The future of aging research is bright with new technologies. Chapters 00:00 Introduction to Longevity and Aging Research 02:50 Combination Therapies in Aging Research 05:57 The Hallmarks of Aging 09:12 Interventions for Rejuvenation 11:57 Stem Cell Therapies and Their Future 15:03 The Role of the Immune System in Aging 17:56 Insights on Aging and Rejuvenation 20:47 Biological Age Testing and Its Implications 24:01 The Future of Gene Therapy in Aging 26:49 Lifestyle Factors and Aging 30:04 Conclusion and Final Thoughts Learn more about Aubrey's work: https://www.levf.org Visit Kayla's website: KaylaBarnes.com

They say aging is just a part of life, but have you ever wondered if it really has to be? What if getting older isn't just something we accept but something we could actually treat?    In this riveting episode of Peak Human Labs Podcast,  Dr. Sanjeev Goel, sits down with Dr. Aubrey de Grey, a trailblazing biomedical gerontologist and Chief Science Officer of the SENS Research Foundation. They dive deep into the revolutionary idea of treating aging as a medical condition. They explore how damage accumulates in our bodies over time and discuss the groundbreaking medical advancements that could extend our healthy lifespans. Dr. de Grey sheds light on the crucial need for investing in underfunded research and shares insights into the future of longevity science. Tune in and envision a future where health and longevity are not just aspirations but achievable realities!   Click HERE to sign in for Dublin Longevity Declaration. Key Takeaways   Aging as a medical condition versus a natural process Mechanisms of damage accumulation in the body Concept of "longevity escape velocity" Role of epigenetic changes in aging Importance of comprehensive interventions targeting different types of damage Current state of therapies for extending human lifespan Economic implications of aging therapies and preventative medicine Research on retroviruses and chronic infections in relation to aging Innovative therapies such as hyperbaric oxygen therapy and therapeutic blood exchange The significance of personalized health approaches and the microbiome's impact on longevity   In This Episode:   [00:00:00] Introduction to longevity research [00:00:51] Guest introduction [00:01:17] Personal connection [00:02:04] Dr. de Grey's background [00:03:14] Early research stages [00:04:05] Understanding aging as a machine [00:05:22] Accumulated damage mechanism [00:06:15] Comprehensive medical control [00:07:13] Categories of damage [00:07:55] Wear and tear concept [00:09:20] Epigenetic changes discussion [00:11:31] Partial reprogramming concept [00:13:30] Addressing multiple mechanisms [00:14:31] Longevity escape velocity [00:15:43] Initial pushback on longevity ideas [00:17:51] Positive outlook on aging research [00:19:51] The future of longevity research [00:20:54] Funding disparities in research [00:21:10] Business models in longevity research [00:21:58] Combining existing therapies [00:23:47] Current longevity therapies [00:24:56] Caloric restriction vs. drugs [00:25:36] Dublin Longevity Declaration [00:26:39] Community building through conferences [00:28:09] Anticipating longevity breakthroughs [00:29:12] Access to longevity therapies [00:30:58] Epigenetic clocks and age reversal [00:32:24] Retroviruses and aging [00:34:56] Persistent viral infections [00:37:24] Hyperbaric oxygen therapy [00:37:49] Therapeutic blood exchange [00:39:37] Discussion on active ingredients [00:40:41] Bone marrow transplant experimentation [00:42:09] Health benefits of bone marrow transplants [00:43:05] Personal health practices [00:43:55] Advice for maximizing healthy lifespan [00:45:01] Microbiome and longevity   Notable Quotes [00:03:14] "The idea that anyone could ever think that aging was just something we should accept has never made any sense to me at all." — Dr. Aubrey de Grey   [00:14:31] "I believe we need to get to about 20 years of postponement of the health problems of late life, which I think we might be able to achieve in the next 12 to 15 years." — Dr. Aubrey de Grey   [00:25:36] "Not only are they my favorite parts of the year, but also they are absolutely the fulcrum, the centerpiece of all of my community building effort." — Dr. Aubrey de Grey   [00:43:36] "I can eat exactly what I like and nothing ever happens, and I don't even need to do any exercise and I still stay fit, so you know, don't do as I do, do as I say." — Dr. Aubrey de Grey   [00:43:55] "Everybody's metabolism has its own strengths and weaknesses, and so honestly, the only generic advice that I feel that one can give in terms of maximizing one's healthy lifespan is to pay close attention to your body." — Dr. Aubrey de Grey   [00:44:28] "I honestly can see a strong argument for just recommending to absolutely everybody that they should eat gluten-free food for like a fortnight, just to see whether they feel different." — Dr. Aubrey de Grey Our Guest   Dr. Aubrey de Grey is a biomedical gerontologist and founder of the LEV Foundation, focused on repairing aging-related cellular damage. Based in Silicon Valley, he earned his BA in computer science and Ph.D. in biology from the University of Cambridge. His research targets the characterization and repair of aging damage. A Fellow of the Gerontological Society of America and the American Aging Association, he advises numerous journals and organizations and is a sought-after speaker at scientific and public events. Resources and Links Peak Human Labs https://www.youtube.com/@peakhumanlabs/videos https://www.peakhuman.ca/ https://www.instagram.com/peakhumanlabs/?hl=en https://open.spotify.com/show/5hx9R37ElxgzCrBccRWoHd?si=8atK0n82QbeL3DWg5-vjvg&nd=1&dlsi=ce0f77aa4f304724   Dr. Sanjeev Goel https://www.linkedin.com/in/sanjeevgoelmd/?originalSubdomain=ca   Dr Aubrey de Grey https://www.levf.org/ https://www.linkedin.com/in/aubrey-de-grey-24260b/ https://web.facebook.com/aubrey.degrey/?_rdc=1&_rdr

“Dr. Admasu earned his PhD in Biochemistry from national university of Singapore. In his PhD work he investigated interactions between lifespan extending drugs with the aim of engineering synergistic benefits in C. elegans. Dr. Admasu is currently a research fellow at SENS Research Foundation. His research focus on isolation and characterization of secondary senescent cells using surface markers and identification of novel approaches to ablate multiple types of senescent cells. He recently identified a novel senolytic approach to kill multiple types of senescent cells.Source: https://www.sens.org/endingagingforum-2022/ About the showThe Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. Learning with lowell linksYoutube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips:https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com/ Tesfahun Admasu linkshttps://www.linkedin.com/in/tessadmasuhttps://scholar.google.com.sg/citations?user=nJA2aaUAAAAJ&hl=enhttps://twitter.com/TessAdmasu Timestamps00:00 Introducing Tesfahun Admasu00:30 Ethiopia Conflict explained18:00 Abiy Ahmed in power21:30 Resolving conflict in Ethiopia23:15 Working for a better Ethiopia27:40 Future of Ethiopia / Abiy Ahmed31:50 Hope for the future of Ethiopia35:40 How can people help Ethiopia39:40 Tesfahun Admasu PhD Singapore / Aging & lifespan Extension47:55 Aging and the Immune system / SENS foundation01:02:08 Non-SENS senolytics trials that you're excited about (FANQ)01:07:05 Book recommendations01:08:33 End comment AgingResearch #EthiopiaConflict #longevity

Prof. Alexandra Stolzing is a pioneer in biogerontological engineering at Loughborough University. With over two decades of experience, including work at SENS Research Foundation, Prof. Stolzing shares insights on:Targeting senescent cells for anti-aging therapiesRevolutionizing cryopreservation techniquesDeveloping breath-based aging biomarkersHarnessing AI for rapid drug discovery in aging researchLearn how her journey from Germany to the UK shaped her multidisciplinary approach to solving aging. Discover the challenges and opportunities in longevity research, including the critical need for basic science funding.Show notes here: https://peterottsjo.beehiiv.com/ Hosted on Acast. See acast.com/privacy for more information.

Our topic in this episode is progress with ending aging. Our guest is the person who literally wrote the book on that subject, namely the book, “Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime”. He is Aubrey de Grey, who describes himself in his Twitter biography as “spearheading the global crusade to defeat aging”.In pursuit of that objective, Aubrey co-founded the Methuselah Foundation in 2003, the SENS Research Foundation in 2009, and the LEV Foundation, that is the Longevity Escape Velocity Foundation, in 2022, where he serves as President and Chief Science Officer.Full disclosure: David also has a role on the executive management team of LEV Foundation, but for this recording he was wearing his hat as co-host of the London Futurists Podcast.The conversation opens with this question: "When people are asked about ending aging, they often say the idea sounds nice, but they see no evidence for any actual progress toward ending aging in humans. They say that they've heard talk about that subject for years, or even decades, but wonder when all that talk is going to result in people actually living significantly longer. How do you respond?"Selected follow-ups:Aubrey de Grey on X (Twitter)The book Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our LifetimeThe Longevity Escape Velocity (LEV) FoundationThe SENS paradigm for ending aging , contrasted with the "Hallmarks of Aging" - a 2023 article in Rejuvenation ResearchProgress reports from the current RMR projectThe plan for RMR 2The RAID (Rodent Aging Interventions Database) analysis that guided the design of RMR 1 and 2Longevity Summit Dublin (LSD): 13-16 June 2024Unblocking the Brain's Drains to Fight Alzheimer's - Doug Ethell of Leucadia Therapeutics at LSD 2023 (explains the possible role of the cribriform plate)Targeting Telomeres to Clear Cancer – Vlad Vitoc of MAIA Biotechnology at LSD 2023How to Run a Lifespan Study of 1,000 Mice - Danique Wortel of Ichor Life Sciences at LSD 2023XPrize HealthspanThe Dublin Longevity Declaration ("DLD")Music: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration

Reason is co-founder and CEO of Repair Biotechnologies. He has been an active angel investor in the longevity industry since its earliest days, with investments including Oisin Biotechnologies and Leucadia Therapeutics. He is a long-standing and well-connected patient advocate for aging research, involved in numerous fundraising and outreach initiatives conducted by organizations such as the Methuselah Foundation and SENS Research Foundation since the early 2000s. He is also the founder and writer of Fight Aging!, a noted news and commentary website in the biotechnology community. Prior to his involvement in the biotechnology industry, Reason was a consultant in the software industry. He holds Masters degrees in Astrophysics from the University of St. Andrews and Space Physics from Rice University.

Dialogues In Longevity - A discussion with Dr. Aubrey de Grey & Dr. Michael Rose about the past, present and future of longevity biotechnology Host - Ira S. Pastor Special thanks to longevity advocate Eric Schulke (https://ruliaderic.wordpress.com/) for helping to organize and coordinate the episode - Dr. Aubrey de Grey, Ph.D., is President & Chief Science Officer of the Longevity Escape Velocity (LEV) Foundation ( https://www.levf.org/ ), an organization focused on proactively identifying and addressing the most challenging obstacles on the path to the widespread availability of genuinely effective treatments to prevent and reverse human age-related disease. Dr. de Grey is internationally recognized as a visionary biomedical gerontologist who devised the Strategies for Engineered Negligible Senescence: a comprehensive set of methods to rejuvenate the human body, thereby preventing age-related ill health and mortality. He has co-founded multiple non-profit organizations – including Methuselah Foundation, SENS Research Foundation, and now LEV Foundation – to specifically enable and accelerate its development and clinical translation. Dr. de Grey received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. He is the author of 'The Mitochondrial Free Radical Theory of Aging', 'Ending Aging', and a large number of academic papers. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the advisory boards of numerous scientific journals and research organizations. He is a prolific speaker who regularly presents at conferences and events world-wide. Dr. Michael Rose, Ph.D. ( https://www.faculty.uci.edu/profile/?facultyId=5261 ) is the Director of the Network for Experimental Research on Evolution (NERE), and Professor in the Department of Ecology and Evolutionary Biology at the University of California, Irvine, where his main area of work over the years has been the evolution of aging. He received his PhD from the University of Sussex in 1978. In 1991, Dr. Rose published seminal work per his text 'Evolutionary Biology of Aging' exploring a view of the subject based on antagonistic pleiotropy, the hypothesis that aging is caused by genes that have two effects, one acting early in life and the other much later. The genes are favored by natural selection as a result of their early-life benefits, and the costs that accrue much later appear as incidental side-effects that we identify as aging. Dr. Rose's laboratory has conducted the longest-running artificial selection experiment designed to test the theory of antagonistic pleiotropy using Fruit flies (Drosophila melanogaster) bred for longevity by collecting eggs from the longest-lived flies in each generation. The experiment has run since 1981, and has produced flies with quadruple the original life span. In 1997, Dr. Rose was awarded the Busse Research Prize by the World Congress of Gerontology. He has authored 10 books, including 'The Long Tomorrow: How Advances in Evolutionary Biology Can Help Us Postpone Aging'. Support the show

The second part of my conversation with George Chanos. He discusses the incredible advances in healthcare and the potential for humans to live longer than ever before. He shares insights from Aubrey de Grey of the SENS Research Foundation, who believes that the first person to live to a thousand years old is alive today. While the specific numbers and timelines are up for debate, George emphasizes that the important thing is that these advancements are coming in our lifetime and will have significant global implications. Get ready for a future of ever-shifting global relations and technological warfare.[00:00:26] Advances in healthcare.[00:05:11] Reversing aging and genetic code change.[00:07:32] Surviving the technological tsunami.[00:11:21] Implications of spatial web.[00:16:07] TikTok as a news source.[00:19:36] Future wars and warfare.[00:25:33] Ukraine's NATO membership debate.[00:28:00] Insect drones in urban areas.[00:31:27] Unlearning and relearning.

Dr. Amit Sharma was awarded a Master's degree in Biomedical Sciences from Delhi University, India. He received his PhD in 2009 in Biotechnology from University of Pune for his work demonstrating microRNA regulation of cytokines invovled in allergic inflammation in mice models. Dr. Sharma's postdoctoral research at the Buck Institute, Novato, California involved investigating novel molecular regulatory pathways in regards to genotoxic stress and cellular senescence in invertebrate and mammalian models. Dr. Sharma has recently joined SENS Research Foundation as Group Lead in the Senescence Immunology Research Group. His research focus involves studying how aging and senescence affects the immune system and his research group will also investigate strategies to harness the immune system in mitigating deleterious effects of senescent cells with translational focus. Newsletter sign up (new and exciting developments)https://learningwithlowell.us12.list-manage.com/subscribe?u=08ed8a56013d8b3a3c01e27fc&id=6ecaa9189b Join this channel to get access to perks: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q/join https://youtu.be/8QwvcRvsT_0 Over 321 books from 170 plus interviews over 5 yearshttps://www.learningwithlowell.com/over-321-books-from-170-interviews-over-5-years-for-autodidacts/ PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com/ Amit Sharma Linkshttps://www.sens.org/about-us/team/https://youtu.be/AoRb1Z0XanMhttps://www.sens.org/our-research/https://www.linkedin.com/in/amit-sharma-1613b189/ Timestamps00:00 Dr. Amit Sharma00:45 Which path to achieve longevity/ healthspan02:40 integrated approach03:50 Typical week working on longevity07:20 Black swan events / SENS foundation08:30 Too high risk ideas09:09 Innovation brain / Elon Musk10:50 Dyslexia thinking in 3d and how Amit thinks12:40 Seeing opportunities14:20 Amit Sharma Leadership style16:00 Spinning off companies vs staying in pure research18:30 Mentorship, life events, inspiration and seeing longevity as the path for her21:00 Skills to be successful in longevity24:55 Project / moments at SENS that is awesome27:15 Longevity and Iron30:17 Visualizing senescence apoptosis32:30 Other uses / Cancer applications / USF34:40 Immune system not aware of eyes35:52 Blood brain barrier degradation with ate, NK cells, t cells36:47 T -cells, inflammation, and alzheimer's38:44 Crazy ideas for treating alzheimer's disease40:40 Cost to build an Amit Sharma center of research within SENS / Idea for Lisa43:00 Donating money to SENS / mito mouse45:00 Ancient infections hiding in genome47:35 Gut microbiome longevity Drosophila52:25 Mice / research / history of work56:30 Cell culture, senescence, mouse models creating new perspectives57:40 FanQ How do you know that the allogeneic CAR-NK cells won't cause Graft vs Host disease?1:00:01 FANQ How many possible senescent cell markers do you think there may be in senescent cells? Do you see being able to target say 70% of Senescent cells with just say 10 markers?1:03:50 FANQ How far do you think you are from an IND application?1:05:55 FANQ Do you have an orphan indication you might want to target first?1:06:50 Book recommendations1:10:00 Amit on never retiring1:10:30 What he needs help with

Dr. Aubrey de Grey, Ph.D., is President & Chief Science Officer of the Longevity Escape Velocity (LEV) Foundation ( https://www.levf.org/ ), an organization focused on proactively identifying and addressing the most challenging obstacles on the path to the widespread availability of genuinely effective treatments to prevent and reverse human age-related disease. Dr. de Grey is internationally recognized as a visionary biomedical gerontologist who devised the Strategies for Engineered Negligible Senescence: a comprehensive set of methods to rejuvenate the human body, thereby preventing age-related ill health and mortality. He has co-founded multiple non-profit organizations – including Methuselah Foundation, SENS Research Foundation, and now LEV Foundation – to specifically enable and accelerate its development and clinical translation. Dr. de Grey received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. He is the author of The Mitochondrial Free Radical Theory of Aging (1999), Ending Aging (2007), and a large number of academic papers. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the advisory boards of numerous scientific journals and research organizations. He is a prolific speaker who regularly presents at conferences and events world-wide. Support the show

Reason is co-founder and CEO of Repair Biotechnologies. He has been an active angel investor in the longevity industry since its earliest days, with investments including Oisin Biotechnologies and Leucadia Therapeutics. He is a long-standing and well-connected patient advocate for aging research, involved in numerous fundraising and outreach initiatives conducted by organizations such as the Methuselah Foundation and SENS Research Foundation since the early 2000s. He is also the founder and writer of Fight Aging!, a noted news and commentary website in the biotechnology community.Cholesterol is presented as much an enemy as a friend in this look at how direct clearance of localized excess cholesterol outperforms other strategies in a number of important medical conditions.Session summary: Reason, Fight Aging | Towards Biotechnology to Finally Defeat Cholesterol - Foresight InstituteThe Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy, co-authored Gaming the Future, and co-initiated The Longevity Prize. Apply to Foresight's virtual salons and in person workshops here!We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page.Visit our website for more content, or join us here:TwitterFacebookLinkedInEvery word ever spoken on this podcast is now AI-searchable using Fathom.fm, a search engine for podcasts. Hosted on Acast. See acast.com/privacy for more information.

  Dr. Aubrey De Grey, a distinguished biomedical gerontologist, is a visionary in the field of aging research. His groundbreaking work has focused on finding ways to slow, prevent, and even reverse the aging process in humans and animals. As the founder of the SENS Research Foundation, Dr. De Grey has played a pivotal role in advancing the field of gerontology and biogerontology.  With his unique background and revolutionary approach to aging, Dr. Aubrey De Grey has upended conventional wisdom, sparking both intrigue and controversy as he seeks to extend healthy human life. But what will be the implications of his discoveries? Dr. De Grey's passion for exploring the possibilities of ageless living has led him to challenge conventional wisdom and inspire countless gerontologists to rethink their approach to aging. Look into the Strategies for Engineered Negligible Senescence (SENS) Foundation, founded by Dr. Aubrey De Grey, to learn more about their research and approach to combating aging and age-related diseases. Explore the concept of Longevity Escape Velocity, which Dr. De Grey has proposed as a way to stay one step ahead of the aging process through repeated application of damage repair therapies. Familiarize yourself with the history of science and the paradigm shifts that have occurred throughout time, as this can help provide context for understanding the resistance Dr. De Grey faced in proposing his ideas on aging. Research the different types of age-related damage and their potential impact on health, including Alzheimer's disease, cancer, arthritis, and sarcopenia, to understand the importance of focusing on health span rather than just life span. Consider the analogy between living organisms and manmade machines, as proposed by Dr. De Grey, to better understand the concept of damage accumulation and the potential for repair in both living and non-living systems. Investigate the concept of negligible senescence as coined by Caleb Finch and how this idea has influenced Dr. De Grey's approach to engineered negligible senescence. Look for opportunities to engage with the gerontology community and participate in discussions surrounding the potential for extending health spans and combating age-related diseases. Engineered Negligible Senescence Engineered Negligible Senescence (ENS) seeks to prevent or reverse the aging process, focusing on the repair of cellular and molecular damage that accrues over time. The underlying principle is that our biological age, determined by the wear and tear our bodies undergo, can be slowed down and potentially extended through vigilant maintenance. The ultimate goal of ENS is not simply to prolong life for its own sake, but to increase health span, curtailing age-related illnesses such as Alzheimer's, cancer, sarcopenia, and arthritis. Dr. Aubrey De Grey, a guest on the Beauty and the BS with Dr. Peter Grossman podcast, elaborated on the concept of ENS and its importance in addressing age-related health problems. Although his ideas faced resistance initially, De Grey remains confident in their potential benefits within his lifetime. By focusing on periodic, preventative maintenance, he believes it may be possible to delay the issues related to aging by 20 or 30 years, ultimately leading to longer, healthier lives. About the Host, Dr. Peter Grossman: https://grossmanmed.com/about Podcast Page: www.beautyandthebspodcast.com

With his unique background and revolutionary approach to aging, Dr. Aubrey De Grey has upended conventional wisdom, sparking both intrigue and controversy as he seeks to extend healthy human life. But what will be the implications of his discoveries? In this episode of Beauty and the BS with Dr. Peter Grossman, you will be able to:  1. Discover the significance of gerontology and biogerontology in addressing the aging process.  2. Understand engineered negligible senescence and its role in comprehensive periodic maintenance.  3. Explore how repairing molecular and cellular damage can counteract aging.  4. Learn about the potential of stem cell therapy as a cutting-edge damage repair strategy.  5. Delve into the controversy surrounding prolonged human life and the benefits it may hold. Dr. Aubrey De Grey, a distinguished biomedical gerontologist, is a visionary in the field of aging research. His groundbreaking work has focused on finding ways to slow, prevent, and even reverse the aging process in humans and animals. As the founder of the SENS Research Foundation, Dr. De Grey has played a pivotal role in advancing the field of gerontology and biogerontology.  With a keen understanding of the complex interplay between molecular and cellular damage, he has developed innovative strategies for promoting healthier, longer lives. Dr. De Grey's passion for exploring the possibilities of ageless living has led him to challenge conventional wisdom and inspire countless gerontologists to rethink their approach to aging. The key moments in this episode are: 00:00:08 - Introduction to Gerontology and Biomedical Gerontology 00:02:13 - Chronological Age versus Biological Age 00:05:03 - Aging and Damage Accumulation 00:11:20 - Engineered Negligible Senescence 00:16:50 - Postponing Aging to Battle Health Issues 00:17:58 - Life Expectancy vs. Lifespan 00:21:17 - Longevity and the Controversy 00:24:02 - Categorizing Aging Damage 00:25:12 - Cell Loss and Stem Cell Therapy 00:27:05 - The Importance of Classification The resources mentioned in this episode are: Look into the Strategies for Engineered Negligible Senescence (SENS) Foundation, founded by Dr. Aubrey De Grey, to learn more about their research and approach to combating aging and age-related diseases. Explore the concept of Longevity Escape Velocity, which Dr. De Grey has proposed as a way to stay one step ahead of the aging process through repeated application of damage repair therapies. Familiarize yourself with the history of science and the paradigm shifts that have occurred throughout time, as this can help provide context for understanding the resistance Dr. De Grey faced in proposing his ideas on aging. Research the different types of age-related damage and their potential impact on health, including Alzheimer's disease, cancer, arthritis, and sarcopenia, to understand the importance of focusing on health span rather than just life span. Consider the analogy between living organisms and manmade machines, as proposed by Dr. De Grey, to better understand the concept of damage accumulation and the potential for repair in both living and non-living systems. Investigate the concept of negligible senescence as coined by Caleb Finch and how this idea has influenced Dr. De Grey's approach to engineered negligible senescence. Look for opportunities to engage with the gerontology community and participate in discussions surrounding the potential for extending health spans and combating age-related diseases. Engineered Negligible Senescence Engineered Negligible Senescence (ENS) seeks to prevent or reverse the aging process, focusing on the repair of cellular and molecular damage that accrues over time. The underlying principle is that our biological age, determined by the wear and tear our bodies undergo, can be slowed down and potentially extended through vigilant maintenance. The ultimate goal of ENS is not simply to prolong life for its own sake, but to increase health span, curtailing age-related illnesses such as Alzheimer's, cancer, sarcopenia, and arthritis. Dr. Aubrey De Grey, a guest on the Beauty and the BS with Dr. Peter Grossman podcast, elaborated on the concept of ENS and its importance in addressing age-related health problems. Although his ideas faced resistance initially, De Grey remains confident in their potential benefits within his lifetime. By focusing on periodic, preventative maintenance, he believes it may be possible to delay the issues related to aging by 20 or 30 years, ultimately leading to longer, healthier lives. About the Host, Dr. Peter Grossman: https://grossmanmed.com/about Podcast Page: www.beautyandthebspodcast.com

Aubrey David Nicholas Jasper de Grey is an English author and biomedical gerontologist. He is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is known for his view that medical technology may enable human beings alive today not to die from age-related causes. As an amateur mathematician, he has contributed to the study of the Hadwiger–Nelson problem in geometric graph theory, making the first progress on the problem in over 60 years. De Grey is an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies. He has been interviewed in recent years in a number of news sources, including CBS 60 Minutes, the BBC, The Guardian, Fortune Magazine, The Washington Post, TED, Popular Science, Playboy, The Colbert Report, Time, the Skeptics' Guide to the Universe, and The Joe Rogan Experience. He was the Chief Science Officer of the SENS Research Foundation. In late 2022, de Grey formed LEV Foundation as President and Chief Science Officer.This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/3240049/advertisement

Instead of a traditional newsletter, we'll do the Joel message and video launch This episode of the Rejuvenation Roundup Podcast features our Rejuvenation Roundup, as well as Ryan O'Shea's episode of Lifespan News on rapamycin's impact on embryo formation and a Life Noggin video on SENS Research Foundation's OncoSENS program! You can also subscribe on your favorite podcasting platform. Learn more at lifespan.io/roundup 0:00 Intro 0:40 Polyphenols and Mediterranean Diet Help with Weight Loss (1) 3:20 Activated Natural Killer Cells Fight Senescence in Humans (2) 5:23 NMN May Improve NAD+ and Walking Speed (3) 9:11 Cancer May Have Finally Met Its Match with OncoSENS (4) 13:00 Rapamycin Reduces DNA Damage & Improves Maturation of Egg Cells (5) Links: 1 - https://www.lifespan.io/news/polyphenols-help-reduce-visceral-fat/ 2 - https://www.lifespan.io/news/activated-natural-killer-cells-fight-senescence-in-humans/ 3 - https://www.lifespan.io/news/study-suggests-nmn-may-improve-nad-and-walking-speed/ 4 - https://youtu.be/r0cnavajNac 5 - https://youtu.be/dfX-lxzXmSA

This episode of the Rejuvenation Roundup Podcast features our Rejuvenation Roundup, as well as Ryan O'Shea's episode of Lifespan News on whether or not coffee is associated with longevity and a Life Noggin video on SENS Research Foundation's MitoSENS program! You can also subscribe on your favorite podcasting platform. Learn more at lifespan.io/roundup 0:00 Intro 0:37 The Effects of Niacin on Alzheimer's in Mice (1) 1:44 Nicotinamide Riboside May Make Existing Cancer Worse (2) 3:58 Protecting Memory Through Gut Bacteria (3) 6:05 Can Drinking Coffee Help You Live Longer? (4) 9:41 Your Body Needs This Tiny Change To Live Longer (5) Links: 1 - https://www.lifespan.io/news/the-effects-of-niacin-on-alzheimers-in-mice/ 2 - https://www.lifespan.io/news/nicotinamide-riboside-may-make-existing-cancer-worse/ 3 - https://www.lifespan.io/news/protecting-memory-through-gut-bacteria/ 4 - https://youtu.be/A3-MenLH-Vk 5 - https://youtu.be/goZ_HPBcT_Q

One area of technology that is frequently in the news these days is rejuvenation biotechnology, namely the possibility of undoing key aspects of biological aging via a suite of medical interventions. What these interventions target isn't individual diseases, such as cancer, stroke, or heart disease, but rather the common aggravating factors that lie behind the increasing prevalence of these diseases as we become older.Our guest in this episode is someone who has been at the forefront for over 20 years of a series of breakthrough initiatives in this field of rejuvenation biotechnology. He is Dr Aubrey de Grey, co-founder of the Methuselah Foundation, the SENS Research Foundation, and, most recently, the LEV Foundation - where 'LEV' stands for Longevity Escape Velocity.Topics discussed include:*) Different concepts of aging and damage repair;*) Why the outlook for damage repair is significantly more tangible today than it was ten years ago;*) The role of foundations in supporting projects which cannot receive funding from commercial ventures;*) Questions of pace of development: cautious versus bold;*) Changing timescales for the likely attainment of robust mouse rejuvenation ('RMR') and longevity escape velocity ('LEV');*) The "Less Death" initiative;*) "Anticipating anticipation" - preparing for likely sweeping changes in public attitude once understanding spreads about the forthcoming available of powerful rejuvenation treatments;*) Various advocacy initiatives that Aubrey is supporting;*) Ways in which listeners can help to accelerate the attainment of LEV.Music: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain DeclarationSome follow-up reading:https://levf.orghttps://lessdeath.org

In the fifth episode of the Longevity & Aging Series, Dr. Amit Sharma, Group Lead from SENS Research Foundation, Mountain View, CA, discusses a research paper he co-authored that was published in Volume 14, Issue 5, of Aging (Aging-US), entitled, “Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells.” DOI - https://doi.org/10.18632/aging.203931 Corresponding Author - Amit Sharma - amit.sharma@sens.org Video - https://www.youtube.com/watch?v=WQR8_gm2gUI Abstract In the context of aging and age-associated diseases, Natural Killer (NK) cells have been revealed as a key cell type responsible for the immune clearance of senescent cells. Subsequently, NK cell-based therapies have emerged as promising alternatives to drug-based therapeutic interventions for the prevention and treatment of age-related disease and debility. Given the promise of NK cell-mediated immunotherapies as a safe and effective treatment strategy, we outline an improved method by which primary NK cells can be efficiently enriched from human peripheral blood across multiple donors (ages 20-42 years old), with a practical protocol that reliably enhances both CD56dim and CD56bright NK cells by 15-fold and 3-fold, respectively. Importantly, we show that our co-culture protocol can be used as an easily adaptable tool to assess highly efficient and selective killing of senescent cells by primary NK cells enriched via our method using longer co-culture durations and a low target to effector ratio, which may be more physiological than has been achieved in previous literature. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.203931 Longevity & Aging Series Aging (Aging-US) and FOXO Technologies have teamed up for a special collaboration on aging research with a monthly video series: Longevity & Aging Series. This series invites Aging researchers to speak with host Dr. Brian Chen, an adjunct faculty member at the University of California San Diego and Chief Science Officer of FOXO Technologies. Learn more - https://www.aging-us.com/longevity Keywords - aging, senescence, natural killer cells, NKCC, immune surveillance About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Explore the latest updates in longevity research in the September 2022 edition of the Rejuvenation Roundup Podcast! This episode of the Rejuvenation Roundup Podcast features our Rejuvenation Roundup, a look at a Life Noggin and SENS Research Foundation video exploring senescent cells (AKA "zombie cells"), Ryan O'Shea's episode of Lifespan News focused on JellyfishDAO, and more! You can also subscribe on your favorite podcasting platform. Learn more at lifespan.io/roundup 0:00 Intro 0:39 Umbilical Plasma Injections Reduce Biological Age in Humans (1) 2:13 Brief Rapamycin Treatment in Early Adulthood Combats Aging (2) 4:27 Ketogenic and Mediterranean Diets vs. Diabetes (3) 7:42 The Zombie Problem Inside of You (4, Life Noggin) 11:09 JellyfishDAO (5, Lifespan News) 16:12 Longevity Summit Dublin Links: 1 - https://www.lifespan.io/news/umbilical-plasma-injections-reduce-biological-age-in-humans/ 2 - https://www.lifespan.io/news/brief-rapamycin-treatment-in-early-adulthood-combats-aging/ 3 - https://www.lifespan.io/news/ketogenic-and-mediterranean-diets-effective-against-diabetes/ 4 - https://youtu.be/X2ixGNRdmpk 5 - https://youtu.be/83dcEIKM3Do 

➡ Nous enregistrons nos podcasts avec Riverside: Cliquer sur le lien pour commencer une période d'essai : https://tinyurl.com/5bxnwnda ⚠️ Découvrez du contenu EXCLUSIF (pas sur la chaîne) ⚠️ ⇒ https://the-flares.com/y/bonus/ ⬇️⬇️⬇️ Infos complémentaires : sources, références, liens... ⬇️⬇️⬇️ Sommaire : 0:00:00 Introduction 0:02:40 Pourquoi souhaitez vaincre le vieillissement et vivre plus longtemps ? 0:04:43 Quelles sont les plus grandes difficultés pour traiter la vieillesse ? 0:08:33 La théorie de réparation des dégâts (damage repair) 0:10:51 Le vieillissement est-il une maladie ou non ? 0:13:05 Quels ont été les progrès effectués dans la recherche ? 0:17:15 Comment convaincre les institutions publiques ? 0:20:13 L'état de la médecine anti-vieillesse en Chine ? 0:21:39 Voit-on une croissance exponentielle dans la recherche contre le vieillissement ? 0:23:00 Que faudrait-il changer pour accélérer la recherche ? 0:25:37 Quelles sont les grandes étapes que nous avons déjà franchies et celles restantes ? 0:28:46 Comment dépasser la limite maximale de durée de vie ? 0:34:31 L'utilité des médicaments et suppléments pour vivre en bonne santé plus longtemps 0:36:00 Le rôle des sénolytiques et thérapie liées au sang ? 0:40:28 Pourquoi les souris testées ne sont pas maintenues en vie ? 0:43:00 Les promesses de la médecine régénérative 0:47:00 Les raisons qui ont poussé Aubrey de Grey a travailler sur le vieillissement 0:49:00 L'affaire "me too" contre Aubrey de Grey 0:51:42 Comment évolua la société si le vieillissement est sous contrôle médical ? 0:53:32 Quel serait le moyen le plus efficace pour accélérer la recherche ? 0:54:54 Les autres centres d'intérêts transhumanistes 0:57:34 Comment contribuer sur le plan personnel ? ----------------------------------------------------------------- ✍️ QUI EST DERRIÈRE CE CONTENU ? ☕ ➡ Production : The Flares - https://the-flares.com ➡ Realisation : Gaëtan Selle - https://www.the-flares.com/y/gaetan-selle/ ➡ Animateurs : Gaëtan Selle - https://www.the-flares.com/y/gaetan-selle/ ➡ Animateurs : Didier Coeurnelle - https://the-flares.com/y/didier-coeurnelle/ -----------------------------------------------------------------

Dr. Kevin Perrott, Ph.D. is Founder and CEO, OpenCures (https://opencures.org/), Adjunct Professor, University of Alberta, Co-Founder and Advisor, Oisin Biotechnologies, President, of Global Healthspan Policy Institute, and Co-Founder and Treasurer, SENS Research Foundation. Kevin is a successful entrepreneur and owner of the largest motorcycle and snowmobile dealership in Canada, Riverside Honda and Skidoo Sales in Edmonton, Alberta. He became a cancer survivor, an experience which clearly highlighted the deficiencies of the current health technology development paradigm where the customer has almost no input in the development of their own health solutions. Armed with the realization that nothing is more valuable than health and the time to enjoy it with those you love, Kevin resolved to put his energies towards addressing these deficiencies. In 2003, Kevin joined Aubrey de Grey and David Gobel to form the Methuselah Foundation which offered competitive prizes for advances in longevity science. A few years later he became a co-founder with Aubrey de Grey and others of SENS Research Foundation to develop interventions able to repair or make harmless the damage that accumulates and underlies multiple age-related disorders. Mostly recently, Kevin formed OpenCures as a for-benefit corporation helping individuals perform self-directed research, generate data, and focus the value of data on the health solutions they are interested in. Kevin has authored and co-authored several peer-reviewed articles all focused on accelerating the science underlying the development of therapies for degenerative diseases. He is a co-founder of multiple non-profit and for-profit entities whose missions are aligned with that purpose. Kevin has a PhD in Biomedical Engineering from University of Alberta, with work performed at the Campisi Lab of the Buck Institute studying the effects of natural compounds on senescence, as well as a BSc, Double Major, in Biology and Chemistry.

#agereversal #lifeextension #humanlongevity #sensfoundation 2021 was a pivotal year in life extension research, we are much closer to finding the elixir which could stop, slow & possibly even revere human aging, Sens Research Foundation has been pioneering in Anti Aging. Dr. Amit Sharma was awarded a Master's degree in Biomedical Sciences from Delhi University, India. He received his Ph.D. in 2009 in Biotechnology from the University of Pune for his work demonstrating microRNA regulation of cytokines involved in allergic inflammation in mice models. Dr. Sharma's postdoctoral research at the Buck Institute, Novato, California involved investigating novel molecular regulatory pathways in regards to genotoxic stress and cellular senescence in invertebrate and mammalian models. Dr. Sharma has recently joined SENS Research Foundation as Group Lead in the Senescence Immunology Research Group. His research focus involves studying how aging and senescence effects the immune system and his research group will also investigate strategies to harness the immune system in mitigating deleterious effects of senescent cells with a translational focus. https://www.linkedin.com/in/amit-sharma-1613b189 https://www.sens.org Kindly Subscribe to CHANGE- I M POSSIBLE youtube channel www.youtube.com/ctipodcast

Most people think about Parkinson's disease as being just what it's called: a disease — a distinct clinical entity, which can be treated as a thing to itself. In fact, however, like all the other diseases of aging, it's the result of the lifelong accumulation of specific kinds of cellular and molecular damage that happen to all of us as part of the biological aging process. PD results from specific kinds of aging damage accumulating in key parts of the brain and nervous system, but similar damage accumulates in other aging tissues, causing dysfunction in those local tissues; these degenerative processes get labeled "diseases" when they reach a tipping point and the tissue can no longer carry out its normal function. The good news is that we now have a strategy for preventing, delaying, and one day even reversing Parkinson's and other diseases of aging through the revolution in rejuvenation biotechnology: therapies that directly remove, repair, replace, or render harmless the damage of aging. By clearing out that damage from the tissues, functionality can be restored and youthful health and vigor with it. SENS Research Foundation https://www.sens.org is a 501(c)3 medical research charity that is working hard to accelerate the development of a comprehensive suite of rejuvenation biotechnologies, to bring the benefits as soon as possible to as many people as possible. My guest today is Michael Rae, Science Writer at SENS Research Foundation, and coauthor with cofounder Dr. de Grey of "Ending Aging:" http://www.amazon.com/dp/0312367074 http://smile.amazon.com/dp/B01EBAP43C/  

Dr. Aubrey de Grey is a biomedical gerontologist and author based in Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) biomedical research charity that performs and funds laboratory research dedicated to combating the aging process. In addition, he is Editor-in-Chief of Rejuvenation Research, the world's highest-impact peer-reviewed journal focused on intervention in aging. He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterisation of all the types of self-inflicted cellular and molecular damage that constitute mammalian aging and the design of interventions to repair and/or obviate that damage. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organisations.

A panel talk with scientists and thought leaders in age reversal and longevity science. Featuring: Aubrey de Grey (Founder of SENS Research Foundation, author of "Ending Aging")  David Sinclair (Harvard Medical School, Life Biosciences, author of "Lifespan: Why We Age -- and Why We Don't Have to") Joao Pedro de Magalhaes (University of Liverpool, CSO at Centaura) Liz Parrish (Founder of Bioviva Science) Jean Hebert (Albert Einstein College of Medicine, author of "Replacing Aging") Alexandra Stolzing (SENS Research Foundation, Loughborough University) Greg Fahy (Intervene Immune) David Gobel (Methuselah Foundation, Methuselah Fund) Hosted by: Laura Minquini (MYKIGAI, Let's Talk Longevity), Avi Roy (Oxford University), and Nathan Cheng (Longevity Marketcap / Longevity List)  

Aubrey de Gray, the godfather of the longevity movement, has catered his research on how to put the breaks on ageing. Passionate about slowing the ageing process, the biomedical gerontologist and chief science officer co-founded the SENS Research Foundation to help fund research on living a longer life.Today, de Gray shares ways we can slow ageing. We discuss the definition of ageing, why we're living longer now than those who lived in the 19th century, and how nutrition plays a part in longevity.We talk about:What made de Gray want to study ageingThe definition of ageing and why we ageThe lifelong process and late-life processWays to extend our livesThe history of age longevity and medicineNutrition and age longevity

Aubrey de Grey is the Chief Science Officer and Co-Founder of SENS Research Foundation, an organization dedicated to changing the way the world researches and treats age-related diseases by researching, developing, and promoting the means to defeat the human aging process. A biomedical gerontologist, he co-authored Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime to explain the science behind the biomedical technology that would slow, and even reverse, aging. He is one of the foremost speakers on the topic of aging as a curable disease.

Better Help: Get 10% off your first month at https://betterhelp.com/impacttheory Taft: Visit taftclothing.com and use code IT10 for 10% off your order of any full priced boot, shoe, or sneaker purchase. Helium 10: Get 50% OFF your first month of Helium 10 Platinum at Helium10.com and use code IMPACT at check out. SHEATH: Go to sheathunderwear.com/impact for 20% off your order with promo code: IMPACT Scientific break-throughs are happening all around you. As technology advances, biologists such as the Chief Science Officer of the SENS Research Foundation, Aubrey de Grey, is leading the way to pioneering tech that will allow you to choose how long you want to live. For years scientists have been trying to find a way to slow down the aging process, but Aubrey introduces the idea of repairing the damage that aging does on the body to theoretically restore the body’s biological age to maybe 30 years younger. If you are familiar with the obsession I’ve had with living forever, you already know how much this excites me.   SHOW NOTES: Quality of Life | Aubrey on why a long life depends on the quality and being invested in choice [0:58] Reverse Aging | Why damage repair could be easier than slowing aging & the push back met [4:40] Indefinite Life | Aubrey on why the result of expected life for reversed aging could be indefinite [8:08] Structure Repair | Landing on the idea of repairing structure to restore cellular level function [9:32] Pushback | Aubrey on pushback among scientists about reverse aging in biology [11:17] Body Damage | Aubrey on self-inflicted damage being reversed to same level 30 years prior [14:13] Longevity Escape Velocity | Aubrey on his theory how to reverse biological age 30 years [16:26] Types of Damage | 7 categories of damage that correspond to therapeutic methods of repair [21:18] Stem Cell Therapy | Aubrey explains how stem cells could treat loss of cell problems [22:17] Cancer Treatments | Aubrey gives category of damage due to too many cells [23:26] Senescent Cells | Aubrey explains how these cells can promote cancer [26:53] Mitochondrial Mutations | Aubrey explains problems at the molecular level inside cells [28:53] Cellular Waste | Aubrey breaks down how cellular waste over years impacts old age [33:35] Macular Degeneration | Aubrey explains specific enzymes that could prevent blindness  [35:24] Excretion | Aubrey explains diseases that could be resolved by breaking down waste [37:50] Alzheimer’s | Breaking down amyloid as extracellular waste and modest benefit [39:22] Advancing Therapies | Aubrey gives sobering guess how close effective therapies are [44:07]     QUOTES: “I want to make sure that my choice about how long to live, and, of course, how high quality that life will be, is not progressively taken away from me by aging.” [2:24]   “Old age is something that evolution doesn't care about at all. Evolution only cares about the propagation of genetic information.” [34:41]   “you've got to fix them all. You haven't got to fix any of them perfectly. But you've got to fix them all pretty well.” [43:28]   “what excites me is typically the breakthroughs that would take me half an hour background to describe why it's even important.” [46:16]   Guest Bio: Dr. de Grey is the biomedical gerontologist who devised the SENS platform and established SENS Research Foundation to implement it. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association   Follow Aubrey De Grey: Website: https://www.sens.org/ Twitter: https://twitter.com/aubreydegrey LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/   Dive Deeper On Related Episodes: Reset Your Age with David Sinclair https://youtu.be/IEz1P4i1P7s Lifestyle For Longevity with Kellyann Petrucci https://youtu.be/l9QO0JlnU8w Secrets To Longevity https://youtu.be/Ulm01gzU8rU  

Check out our sponsors: Better Help: Get 10% off your first month at https://betterhelp.com/impacttheory Taft: Visit taftclothing.com and use code IT10 for 10% off your order of any full priced boot, shoe, or sneaker purchase. Helium 10: Get 50% OFF your first month of Helium 10 Platinum at Helium10.com and use code IMPACT at check out. SHEATH: Go to sheathunderwear.com/impact for 20% off your order with promo code: IMPACT Scientific break-throughs are happening all around you. As technology advances, biologists such as the Chief Science Officer of the SENS Research Foundation, Aubrey de Grey, is leading the way to pioneering tech that will allow you to choose how long you want to live. For years scientists have been trying to find a way to slow down the aging process, but Aubrey introduces the idea of repairing the damage that aging does on the body to theoretically restore the body’s biological age to maybe 30 years younger. If you are familiar with the obsession I’ve had with living forever, you already know how much this excites me.   SHOW NOTES: Quality of Life | Aubrey on why a long life depends on the quality and being invested in choice [0:58] Reverse Aging | Why damage repair could be easier than slowing aging & the push back met [4:40] Indefinite Life | Aubrey on why the result of expected life for reversed aging could be indefinite [8:08] Structure Repair | Landing on the idea of repairing structure to restore cellular level function [9:32] Pushback | Aubrey on pushback among scientists about reverse aging in biology [11:17] Body Damage | Aubrey on self-inflicted damage being reversed to same level 30 years prior [14:13] Longevity Escape Velocity | Aubrey on his theory how to reverse biological age 30 years [16:26] Types of Damage | 7 categories of damage that correspond to therapeutic methods of repair [21:18] Stem Cell Therapy | Aubrey explains how stem cells could treat loss of cell problems [22:17] Cancer Treatments | Aubrey gives category of damage due to too many cells [23:26] Senescent Cells | Aubrey explains how these cells can promote cancer [26:53] Mitochondrial Mutations | Aubrey explains problems at the molecular level inside cells [28:53] Cellular Waste | Aubrey breaks down how cellular waste over years impacts old age [33:35] Macular Degeneration | Aubrey explains specific enzymes that could prevent blindness  [35:24] Excretion | Aubrey explains diseases that could be resolved by breaking down waste [37:50] Alzheimer’s | Breaking down amyloid as extracellular waste and modest benefit [39:22] Advancing Therapies | Aubrey gives sobering guess how close effective therapies are [44:07]     QUOTES: “I want to make sure that my choice about how long to live, and, of course, how high quality that life will be, is not progressively taken away from me by aging.” [2:24]   “Old age is something that evolution doesn't care about at all. Evolution only cares about the propagation of genetic information.” [34:41]   “you've got to fix them all. You haven't got to fix any of them perfectly. But you've got to fix them all pretty well.” [43:28]   “what excites me is typically the breakthroughs that would take me half an hour background to describe why it's even important.” [46:16]   Guest Bio: Dr. de Grey is the biomedical gerontologist who devised the SENS platform and established SENS Research Foundation to implement it. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association   Follow Aubrey De Grey: Website: https://www.sens.org/ Twitter: https://twitter.com/aubreydegrey LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/   Dive Deeper On Related Episodes: Reset Your Age with David Sinclair https://youtu.be/IEz1P4i1P7s Lifestyle For Longevity with Kellyann Petrucci https://youtu.be/l9QO0JlnU8w Secrets To Longevity https://youtu.be/Ulm01gzU8rU    

BONUS EPISODES & EARLY RELEASES: https://www.patreon.com/auxoro Aubrey de Grey is a research scientist, author, and Chief Science Officer of the SENS Research Foundation.  Aubrey de Grey Links:Ending AgingSENS Research FoundationDonate to SENSSubscribe to SENS Newsletter Auxoro Links:InstagramFacebookTwitterTikTokYouTubeNewsletterPatreon (Bonus Episodes + Early Releases) 

Our YouTube Channel is here Please visit us for more longevity and extended healthspan content. In this podcast Dr. de Grey will talk about the hallmarks of aging that he defined and more specifically about the stiffening of the extra cellular matrix a hallmark that was in his original list but not the 2013 paper. Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process. The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime https://amzn.to/37lBX7A SENS Foundation https://www.sens.org/ 2013 paper on the 9 hallmarks of aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging

Our YouTube Channel is here Please visit us for more longevity and extended healthspan content. In this podcast Dr. de Grey talks about why SENS was founder and why the research that the foundation undertakes is not done by other organizations. Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process. The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime https://amzn.to/37lBX7A SENS Foundation https://www.sens.org/ 2013 paper on the 9 hallmarks of aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging

Our YouTube Channel is here Please visit us for more longevity and extended healthspan content. In this podcast Dr. de Grey talks about his view on the latest rejuvenation technology. Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process. The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime https://amzn.to/37lBX7A SENS Foundation https://www.sens.org/ 2013 paper on the 9 hallmarks of aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging

Our YouTube Channel is here Please visit us for more longevity and extended healthspan content. In this podcast Dr. de Grey talks about his view of what the future of aging will look like Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process. The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime https://amzn.to/37lBX7A SENS Foundation https://www.sens.org/ 2013 paper on the 9 hallmarks of aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging

Our YouTube Channel is here Please visit us for more longevity and extended healthspan content. In this podcast Dr. de Grey talks about how the idea of an extended lifespan is being accepted by society and some of the implications of this. Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process. The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime https://amzn.to/37lBX7A SENS Foundation https://www.sens.org/ 2013 paper on the 9 hallmarks of aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging

Since the beginning of civilization, humans have been fueled by a desire to avoid the decay that's coming with old age. Today, we spend billions of dollars each year to eradicate cancer, dementia or diabetes. But even when we find cures for these and other diseases, we still don't change our ultimate prognosis: death. But what if, instead of focusing on diseases, we would focus on eradicating aging and reverse engineering our biological clock? Today, science is on the brink of providing us with the proverbial Fountain of Youth and the possibility of living radically extended and healthy lifespans. For those who are familiar with the subjects of aging, transhumanism and futurology, today's guest, Dr. Aubrey de Grey needs no introduction. He is the biomedical gerontologist known for his view that medical technology will one day allow humans to control the aging process and live healthily into our hundreds, or maybe even thousands. In fact, Aubrey has said that the first human being to live to 500 years old may already be alive today. Dr. Aubrey de Grey is the Chief Science Officer of SENS Research Foundation, a California based biomedical research charity that performs and funds laboratory research dedicated to combating aging. In addition, Aubrey is editor-in-chief of Rejuvenation Research, the world's highest impact peer-reviewed journal focused on intervention in aging. In this conversation with Aubrey, you'll hear:02:36 Why aging is the biggest health crisis the world is facing 04:28 The reason why we think about aging differently than other diseases 07:11 What causes aging 08:46 The hallmarks of aging and the strategies to prevent them 15:07 Does it make sense to maintain ourselves as well as possible until the anti aging technologies arrive via diet, biohacking and self care? 18:22 Why it is vital politicians and policy makers deal with the topic of drastically extended lifespan now. 24:08 How society and our economic systems will benefit from a healthy older generation with a drastically extended lifespan 25:53 Why overpopulation is not the problem it is commonly thought to be with regards to drastically extended lifespans 33:48 How far we are from the point in time when people will live to 150 years and more 41:32 Aubrey's practices Resources mentioned in this episode: https://www.sens.org (SENS Research Foundation) https://amzn.to/3vmjUZR (Lifespan: Why We Age and Why We don't Have to) by David Sinclair

Our YouTube Channel is here Please visit us for more longevity and extended healthspan content. In this podcast Dr. de Grey will talk about his view on the epigenetic aging clocks and their value in aging research. Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process. The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime https://amzn.to/37lBX7A SENS Foundation https://www.sens.org/ 2013 paper on the 9 hallmarks of aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging

Our YouTube Channel is here Please visit us for more longevity and extended healthspan content. In this podcast Dr. de Grey will talk about the hallmarks of aging that he defined and more specifically about the stiffening of the extra cellular matrix a hallmark that was in his original list but not the 2013 paper. Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process. The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime https://amzn.to/37lBX7A SENS Foundation https://www.sens.org/ 2013 paper on the 9 hallmarks of aging https://www.sciencedirect.com/science/article/pii/S0092867413006454 Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging

Aubrey de Grey is an English author and theoretician in the field of gerontology and the Chief Science Officer of the SENS Research Foundation.

Sought after guest speaker, Aubrey de Grey, has appeared on numerous popular programs including CBS 60 Minutes, BBC, TED and The Colbert Report to name just a few. Today, he joins The Future Tech Podcast, to share his vision on how we can improve the aging process through enhancing the human body's capability of rejuvenation through cell immortality and pluripotency to human aging and age-related disease. The. Vice President of New Technology and Discovery at AgeX Therapeutics, Aubrey de Grey, Ph.D., is also the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) biomedical research charity that performs, and funds research devoted to battling the progression of aging. In this fascinating discussion, Aubrey explains some of the obstacles that need to be overcome, including issues involving age-related tissue damage and stem cell decline which contribute to accelerating the aging process. He also discusses what AgeX is doing in stem cell research and in regenerative medicine that will improve not only the longevity of life, but also the quality and health of individuals throughout the aging process. He also touches on what he sees could be the future in the science of aging and treatments being worked on by the rejuvenation research community. For more information, visit: www.agexinc.com

Topic: Fifty Years of SETI--Where is Everyone? Our speaker is Robert Buetner, the award-winning author of more than ten novels, a former intelligence officer, paleontologist, and lawyer. [News Item] Lifespan.io is a new crowdfunding platform dedicated specifically to research aimed at extending healthy human lifespan. Through centralizing such crowdfunding efforts, it can help create a powerful grassroots movement to overcome age-related disease—both by building a community of passionate donors who can fund research directly and by providing an accessible gateway for the public at large to be introduce to the idea of life extension. The first campaign, from the SENS Research Foundation, is already over 50% funded, and more projects will be launching soon. Please visit www.Lifespan.io to join the cause, and help #CrowdfundTheCure for aging. Hosted by Stephen Euin Cobb, this is the September 9, 2015 episode of The Future And You. [Running time: 37 minutes] This discussion was recorded in front of an audience at the science fiction and fantasy convention LibertyCon in Chattanooga TN, on June 27, 2015. Stephen Euin Cobb has interviewed over 350 people for his work as an author, futurist, magazine writer, ghostwriter, and award-winning podcaster. A contributing editor for Space and Time Magazine; he has also been a regular contributor for Robot, H+, Grim Couture and Port Iris magazines; and he spent three years as a columnist and contributing editor for Jim Baen's Universe Magazine. For the last nine years he has produced a weekly podcast, The Future And You, which explores (through interviews, panel discussions and commentary) all the ways the future will be different from today. He is an artist, essayist, game designer, transhumanist, and is on the Advisory Board of The Lifeboat Foundation. Stephen is the author of an ebook about the future entitled: Indistinguishable from Magic: Predictions of Revolutionary Future Science.

Aubrey de Grey is an English author and theoretician in the field of gerontology and the Chief Science Officer of the SENS Research Foundation. http://sens.org/