Podcasts about Rejuvenation Research

‘That's the secret of fasting. It's the miracle of regeneration of the cells or rejuvenations of the cell to catch the fat, decreases the fat and gives you that enhancement in energy and mood and performance. So it is a life changing experience within a short period of time.' - Dr. Joseph Antoun, CEO and Chairman of the Board of L-Nutra   My guest today is Dr. Joseph Antoun, CEO and Chairman of the Board of L-Nutra.   Dr. Antoun has dedicated his professional experience to reforming health systems towards preventive care. He is the CEO and Chairman of the Board of L-Nutra and is passionate about bringing back fasting as a longevity practice to humanity.   Please enjoy!   In case you missed it, we've put together an Ultimate Holiday Gift Guide (with lots of health optimization & biohacking goodies) in case you're in need of some holiday gift inspiration! Go to LLGiftGuide.com to get your free Gift Guide. For Podcast Show Notes & Transcript visit: https://longevity-and-lifestyle.com/podcast-88-joseph-antoun Follow Dr. Joseph Antoun on: LinkedIn: https://www.linkedin.com/in/drjosephantoun/ Facebook: https://www.facebook.com/DrJosephAntoun/    Follow L-Nutra on: Website: https://l-nutra.com/  Facebook: https://www.facebook.com/LNutra/  Twitter: https://twitter.com/lnutraofficial?lang=en    Follow Claudia on: Instagram: https://www.instagram.com/longevityandlifestyle/?hl=en Facebook: https://www.facebook.com/longevityandlifestyle/ YouTube: https://www.youtube.com/channel/UCZF-s8jsUejc0TpVqnFE1lQ/featured LinkedIn: https://www.linkedin.com/in/claudia-von-boeselager/ Twitter: https://twitter.com/LongevityLifest Website: https://longevity-and-lifestyle.com/   Past guests on The Longevity & Lifestyle Podcast include Dr. David Perlmutter, Dr. Amy Killen, Sergey Young, Dr. Dale Bredesen, Dr. Kristen Willeumier, Dr. Louise Newson, Dr. Kien Vuu, Dr. Carolina Reis, Marie Diamond, Nikolina Lauc, Morri Chowaiki, Leslie Kenny, Maziar Brumand, Fiona O'Donnell-McCarthy, Mohamed Massaquoi, Nick Potter, Dr. Pamela Kryskow, Dr. Julia Mirer, Dr. Julia Jones, Dr. Austin Perlmutter, Dr. Richard Johnson, Isabella Channing, Dina Burkitbayeva, Raewyn Guerrero, Mario Chamorro, Mariko Bangerter, Harris Khan, Juraj Kocar, Dr. Stephanie Manson Brown, Dr. Mohammed Enayat, Dr. Molly Maloof, Helen Reavey, Elena Letyagina, Dana Frost, Niall Breslin, Dr. Limor Goren, Larisa Petrini, Leighanne Champion, Mike Bennet, Dr. Louise Swartswalter, Dr. Joseph Antoun and many more!

Dr. Aubrey de Grey is a biomedical gerontologist and author based in Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) biomedical research charity that performs and funds laboratory research dedicated to combating the aging process. In addition, he is Editor-in-Chief of Rejuvenation Research, the world's highest-impact peer-reviewed journal focused on intervention in aging. He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterisation of all the types of self-inflicted cellular and molecular damage that constitute mammalian aging and the design of interventions to repair and/or obviate that damage. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organisations.

Better Help: Get 10% off your first month at https://betterhelp.com/impacttheory Taft: Visit taftclothing.com and use code IT10 for 10% off your order of any full priced boot, shoe, or sneaker purchase. Helium 10: Get 50% OFF your first month of Helium 10 Platinum at Helium10.com and use code IMPACT at check out. SHEATH: Go to sheathunderwear.com/impact for 20% off your order with promo code: IMPACT Scientific break-throughs are happening all around you. As technology advances, biologists such as the Chief Science Officer of the SENS Research Foundation, Aubrey de Grey, is leading the way to pioneering tech that will allow you to choose how long you want to live. For years scientists have been trying to find a way to slow down the aging process, but Aubrey introduces the idea of repairing the damage that aging does on the body to theoretically restore the body’s biological age to maybe 30 years younger. If you are familiar with the obsession I’ve had with living forever, you already know how much this excites me.   SHOW NOTES: Quality of Life | Aubrey on why a long life depends on the quality and being invested in choice [0:58] Reverse Aging | Why damage repair could be easier than slowing aging & the push back met [4:40] Indefinite Life | Aubrey on why the result of expected life for reversed aging could be indefinite [8:08] Structure Repair | Landing on the idea of repairing structure to restore cellular level function [9:32] Pushback | Aubrey on pushback among scientists about reverse aging in biology [11:17] Body Damage | Aubrey on self-inflicted damage being reversed to same level 30 years prior [14:13] Longevity Escape Velocity | Aubrey on his theory how to reverse biological age 30 years [16:26] Types of Damage | 7 categories of damage that correspond to therapeutic methods of repair [21:18] Stem Cell Therapy | Aubrey explains how stem cells could treat loss of cell problems [22:17] Cancer Treatments | Aubrey gives category of damage due to too many cells [23:26] Senescent Cells | Aubrey explains how these cells can promote cancer [26:53] Mitochondrial Mutations | Aubrey explains problems at the molecular level inside cells [28:53] Cellular Waste | Aubrey breaks down how cellular waste over years impacts old age [33:35] Macular Degeneration | Aubrey explains specific enzymes that could prevent blindness  [35:24] Excretion | Aubrey explains diseases that could be resolved by breaking down waste [37:50] Alzheimer’s | Breaking down amyloid as extracellular waste and modest benefit [39:22] Advancing Therapies | Aubrey gives sobering guess how close effective therapies are [44:07]     QUOTES: “I want to make sure that my choice about how long to live, and, of course, how high quality that life will be, is not progressively taken away from me by aging.” [2:24]   “Old age is something that evolution doesn't care about at all. Evolution only cares about the propagation of genetic information.” [34:41]   “you've got to fix them all. You haven't got to fix any of them perfectly. But you've got to fix them all pretty well.” [43:28]   “what excites me is typically the breakthroughs that would take me half an hour background to describe why it's even important.” [46:16]   Guest Bio: Dr. de Grey is the biomedical gerontologist who devised the SENS platform and established SENS Research Foundation to implement it. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association   Follow Aubrey De Grey: Website: https://www.sens.org/ Twitter: https://twitter.com/aubreydegrey LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/   Dive Deeper On Related Episodes: Reset Your Age with David Sinclair https://youtu.be/IEz1P4i1P7s Lifestyle For Longevity with Kellyann Petrucci https://youtu.be/l9QO0JlnU8w Secrets To Longevity https://youtu.be/Ulm01gzU8rU  

Check out our sponsors: Better Help: Get 10% off your first month at https://betterhelp.com/impacttheory Taft: Visit taftclothing.com and use code IT10 for 10% off your order of any full priced boot, shoe, or sneaker purchase. Helium 10: Get 50% OFF your first month of Helium 10 Platinum at Helium10.com and use code IMPACT at check out. SHEATH: Go to sheathunderwear.com/impact for 20% off your order with promo code: IMPACT Scientific break-throughs are happening all around you. As technology advances, biologists such as the Chief Science Officer of the SENS Research Foundation, Aubrey de Grey, is leading the way to pioneering tech that will allow you to choose how long you want to live. For years scientists have been trying to find a way to slow down the aging process, but Aubrey introduces the idea of repairing the damage that aging does on the body to theoretically restore the body’s biological age to maybe 30 years younger. If you are familiar with the obsession I’ve had with living forever, you already know how much this excites me.   SHOW NOTES: Quality of Life | Aubrey on why a long life depends on the quality and being invested in choice [0:58] Reverse Aging | Why damage repair could be easier than slowing aging & the push back met [4:40] Indefinite Life | Aubrey on why the result of expected life for reversed aging could be indefinite [8:08] Structure Repair | Landing on the idea of repairing structure to restore cellular level function [9:32] Pushback | Aubrey on pushback among scientists about reverse aging in biology [11:17] Body Damage | Aubrey on self-inflicted damage being reversed to same level 30 years prior [14:13] Longevity Escape Velocity | Aubrey on his theory how to reverse biological age 30 years [16:26] Types of Damage | 7 categories of damage that correspond to therapeutic methods of repair [21:18] Stem Cell Therapy | Aubrey explains how stem cells could treat loss of cell problems [22:17] Cancer Treatments | Aubrey gives category of damage due to too many cells [23:26] Senescent Cells | Aubrey explains how these cells can promote cancer [26:53] Mitochondrial Mutations | Aubrey explains problems at the molecular level inside cells [28:53] Cellular Waste | Aubrey breaks down how cellular waste over years impacts old age [33:35] Macular Degeneration | Aubrey explains specific enzymes that could prevent blindness  [35:24] Excretion | Aubrey explains diseases that could be resolved by breaking down waste [37:50] Alzheimer’s | Breaking down amyloid as extracellular waste and modest benefit [39:22] Advancing Therapies | Aubrey gives sobering guess how close effective therapies are [44:07]     QUOTES: “I want to make sure that my choice about how long to live, and, of course, how high quality that life will be, is not progressively taken away from me by aging.” [2:24]   “Old age is something that evolution doesn't care about at all. Evolution only cares about the propagation of genetic information.” [34:41]   “you've got to fix them all. You haven't got to fix any of them perfectly. But you've got to fix them all pretty well.” [43:28]   “what excites me is typically the breakthroughs that would take me half an hour background to describe why it's even important.” [46:16]   Guest Bio: Dr. de Grey is the biomedical gerontologist who devised the SENS platform and established SENS Research Foundation to implement it. He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association   Follow Aubrey De Grey: Website: https://www.sens.org/ Twitter: https://twitter.com/aubreydegrey LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/   Dive Deeper On Related Episodes: Reset Your Age with David Sinclair https://youtu.be/IEz1P4i1P7s Lifestyle For Longevity with Kellyann Petrucci https://youtu.be/l9QO0JlnU8w Secrets To Longevity https://youtu.be/Ulm01gzU8rU    

Dr. Aubrey de Grey is a biomedical gerontologist based in Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) biomedical research charity that performs and funds laboratory research dedicated to combating the aging process. In addition, he is Editor-in-Chief of Rejuvenation Research, the world's highest-impact peer-reviewed journal focused on intervention in aging. He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterization of all the types of self-inflicted cellular and molecular damage that constitute mammalian aging and the design of interventions to repair and/or obviate that damage. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits (uncompensated) on the editorial and scientific advisory boards of numerous journals and organizations. He is a highly sought-after speaker who gives 40-50 invited talks per year at scientific conferences, universities, companies in areas ranging from pharmaceutical to life insurance, and to the public. Support the show (http://www.paypal.me/BangProductions )

Since the beginning of civilization, humans have been fueled by a desire to avoid the decay that's coming with old age. Today, we spend billions of dollars each year to eradicate cancer, dementia or diabetes. But even when we find cures for these and other diseases, we still don't change our ultimate prognosis: death. But what if, instead of focusing on diseases, we would focus on eradicating aging and reverse engineering our biological clock? Today, science is on the brink of providing us with the proverbial Fountain of Youth and the possibility of living radically extended and healthy lifespans. For those who are familiar with the subjects of aging, transhumanism and futurology, today's guest, Dr. Aubrey de Grey needs no introduction. He is the biomedical gerontologist known for his view that medical technology will one day allow humans to control the aging process and live healthily into our hundreds, or maybe even thousands. In fact, Aubrey has said that the first human being to live to 500 years old may already be alive today. Dr. Aubrey de Grey is the Chief Science Officer of SENS Research Foundation, a California based biomedical research charity that performs and funds laboratory research dedicated to combating aging. In addition, Aubrey is editor-in-chief of Rejuvenation Research, the world's highest impact peer-reviewed journal focused on intervention in aging. In this conversation with Aubrey, you'll hear:02:36 Why aging is the biggest health crisis the world is facing 04:28 The reason why we think about aging differently than other diseases 07:11 What causes aging 08:46 The hallmarks of aging and the strategies to prevent them 15:07 Does it make sense to maintain ourselves as well as possible until the anti aging technologies arrive via diet, biohacking and self care? 18:22 Why it is vital politicians and policy makers deal with the topic of drastically extended lifespan now. 24:08 How society and our economic systems will benefit from a healthy older generation with a drastically extended lifespan 25:53 Why overpopulation is not the problem it is commonly thought to be with regards to drastically extended lifespans 33:48 How far we are from the point in time when people will live to 150 years and more 41:32 Aubrey's practices Resources mentioned in this episode: https://www.sens.org (SENS Research Foundation) https://amzn.to/3vmjUZR (Lifespan: Why We Age and Why We don't Have to) by David Sinclair

Dr. Aubrey de Grey is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) charity dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world's highest-impact peer-reviewed journal focused on intervention in aging. EPISODE LINKS: SENS Research Foundation Website: https://www.sens.org/​ Aubrey de Grey's Twitter: https://twitter.com/aubreydegrey​ Ian Bott's Twitter: https://twitter.com/IanBott​ OUTLINE: 0:00​ - Introduction 1:43​ - How to define "aging" 3:25​ - The importance of ending aging 4:05​ - Why a "pro-aging trance" exists 5:59​ - Why repair is better than prevention 8:49​ - The central causes of aging 10:44​ - The impact of CRISPR 13:11​ - Rapid vs. Incremental Progress 14:36​ - "Eureka" Moments 15:56​ - Motivation to work on rejuvenation 17:51​ - Background as an AI researcher 18:38​ - When to "break the rules" 20:41​ - Problems with how research is funded 24:43​ - The "triangular logjam" 28:08​ - How to support human longevity research 29:07​ - How human values might change CONNECT: Subscribe to this YouTube channel United Sigma Intelligence Association (USIA): https://usiassociation.org​ USIA Twitter:

Dr. Aubrey de Grey is a biomedical gerontologist based in Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) biomedical research charity that performs and funds laboratory research dedicated to combating aging. In addition, he is Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in aging.He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterization of all the types of self-inflicted cellular and molecular damage that constitute mammalian aging and the design of interventions to repair and/or obviate that damage.Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations. He is a highly sought-after speaker who gives 40-50 invited talks per year at scientific conferences, universities, companies in areas ranging from pharma to life insurance, and to the public.Topics Discussed:Brief overview of SENSWhy try to end aging?How soon do you think we will end aging?What role does rejuvenation biotech play in the COVID-19 pandemic? How would regenerative medicine help us better cope with the pandemic?How are you implementing the techniques you research in your own life?Which breakthrough are you most proud of?Aubrey's Links:LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/Personal Website: https://www.sens.org/Company Website: https://www.mfoundation.org/Twitter: https://twitter.com/aubreydegrey

Ira Pastor, ideaXme exponential health ambassador, interviews Dr. Michael B. Fossel, M.D., Ph.D., Founder and President of Telocyte. Ira Pastor Comments: Today we are going to journey back to the topic of Alzheimer’s disease, which as we’ve discussed on previous episodes, is one of those conditions, that while not responsible for as many annual deaths as cancer or heart disease, is a problem that is growing substantially in our rapidly aging population, and is predicted to become an epidemic of major proportions (in both direct and indirect costs to society) in the coming decades. Estimates vary, but experts suggest that more than 5.5 million Americans, most of them age 65 or older, may have dementia caused by Alzheimer’s, with an estimated 18 million elderly people worldwide afflicted. This burden is projected to grow to 14 million in the U.S. in 2060 and over 100 million globally. It is truly a disease of “substantial unmet medical need.” Alzheimer's Disease: There is no cure for Alzheimer's disease; available treatments offer relatively small symptomatic benefit and remain palliative in nature. The predominant area of clinical research, which is focused on treating what has been thought to be the primary underlying disease pathology, beta-amyloid plaque formation, and hence its attempted reduction via traditional drugs, scavenging by immunotherapies, etc., have been using up billions in research funding and have yielded lacklustre results to date – so much so that many members of big pharma are getting out of the Alzheimer’s therapeutics space entirely. This has prompted a set of thought leaders to ask the big question: is b-amyloid even the right target? Or is it (and related Tau neurofibrillary tangles or damage) far downstream from much more important biological events that we should be paying more attention to? On a few previous episodes we've touched on some of these themes – we’ve talked about the infectious dimension of Alzheimer's and dementia (in regards to work on chronic herpes infection); we’ve talked with folks that look at Alzheimer's as a new form of diabetes and more from an endocrine angle. Dr. Michael B. Fossel We have a fascinating guest today. Dr. Michael B. Fossel, M.D., Ph.D., is Founder and President of Telocyte, who has recently published a fascinating review in the Journal of Alzheimer's Association entitled “A Unified Model of Dementias and Age‐Related Neurodegeneration,” which focuses on the theme of a failing class of brain cells becoming senescent (entering a state of irreversible cell cycle arrest), called glia (non-neuronal cells in the central nervous system that maintain homeostasis, and provide support and protection for neurons) as a major driver of Alzheimer’s and other dementias, and is working on an innovative gene therapy that could target these cells to keep dementia at bay. Dr. Fossel was most recently professor of clinical medicine at Michigan State University and is a respected lecturer, author, and the founder and former editor-in-chief of the Journal of Anti-Aging Medicine (now known as Rejuvenation Research). Dr. Fossel earned his M.D. at Stanford Medical School, and a Ph.D. in neurobiology at Stanford University. In addition to his position at Michigan State University, Dr. Fossel has lectured at the National Institute for Health, the Smithsonian Institution, and at various other universities and institutes in various parts of the world. Dr. Fossel served on the board of directors for the American Aging Association and was their executive director. Dr. Fossel has written numerous articles on aging and ethics as well as authored and co-authored several books including - The Telomerase Revolution, The Immortality Edge, Reversing Human Aging, and Cells, Aging, and Human Disease. On today's show we will hear from Dr. Fossel About his background, how he became interested in medicine, in aging, and in the neurobiology of Alzheimer's. An overview of Glial cells as an important target in the pathology of Alzheimer's. A history of telomeres and telomerase in the areas of cellular aging and cancer and relevance towards Alzheimer's disease progression. Next steps in the development of Telocyte and it's gene therapy candidate(s) for Alzheimer's and other aging pathologies. Follow Ira Pastor on Twitter:@IraSamuelPastor If you liked this interview, be sure to check out ourinterview on studying evolution to banish aging! Follow ideaXme on Twitter:@ideaxm On Instagram:@ideaxme Find ideaXme across the internet including on iTunes, YouTube, SoundCloud, Radio Public, TuneIn Radio, I Heart Radio, Google Podcasts, Spotify and more. ideaXme is a global podcast, creator series and mentor programme. Our mission: Move the human story forward!™ ideaXme Ltd.

Meet Aubrey De Grey – Chief Science Officer at SENS Research Foundation, VP of New Technology Discovery at AgeX Therapeutics, and editor-in-chief of Rejuvenation Research, the highest-impact peer-reviewed academic journal focused on postponing aging. He works on the development of medical innovations that can postpone all forms of age-related ill-health with an undivided focus is on rejuvenation: that is, the active repair of the various types of molecular and cellular damage which eventually cause age-related disease and disability, as opposed to the mere retardation of the accumulation of such damage. Our guest tells his story of how he came to be a biologist from being destined to be a pianist according to his mother in the beginning and later choosing programming out of a wish to make more of a contribution to the progress of mankind. Insights Switching fields and how it helped Aubrey find fulfilment in his work. Understanding the process of aging – how it happens and what is the rational, sustainable, and effective way to combat it. Why public awareness on the topic is important, and how Aubrey has been striving to raise awareness. What makes us age faster is not just the unhealthy habits of ours, but also the mechanisms like breathing that are essential to our life. Whether fasting helps you combat the aging process or not. A revolutionary view in gerontology and how it became mainstream, thanks to Aubrey's untiring efforts. Where we hope to be in the coming decades in terms of defeating the process of aging altogether or even partially. Why individual contributions are important in the field of gerontology. Aubrey and his foundations Connect on LinkedIn - https://www.linkedin.com/in/aubrey-de-grey-24260b/ - SENS Research Foundation - https://www.sens.org/ The Methuselah Foundation - https://www.mfoundation.org/ ABOUT THE HOST My name is Sam Harris. I am a British entrepreneur, investor and explorer. From hitchhiking across Kazakstan to programming AI doctors I am always pushing myself in the spirit of curiosity and Growth. My background is in Biology and Psychology with a passion for improving the world and human behaviour. I have built and sold companies from an early age and love coming up with unique ways to make life more enjoyable and meaningful. Sam: Instagram (https://www.instagram.com/samjamsnaps/) Quora (https://www.quora.com/profile/Sam-Harris-58) Twitter (https://twitter.com/samharristweets) LinkedIn (https://www.linkedin.com/in/sharris48/) Sam's blog - SamWebsterHarris.com (https://samwebsterharris.com/) Support the Show - Patreon (https://www.patreon.com/growthmindset) Sponsor - Feals (https://feals.com/growth) Feals has me feeling my best every day and it can help you too.  Become a member today by going to Feals dot com slash growth and you'll get 50% off your first order with free shipping.  That’s F-E-A-L-S dot com slash growth to become a member and get 50% automatically taken off your first order with free shipping.  Feals dot com slash growth. Summary Aubrey's Career Path "I wanted to be a scientist, but ultimately, I wanted to make a difference to the world. And I recognized that scientists, in the long run, make the most difference.” Having chosen programming at the age of 15 and for the purpose of making more of a difference to the world, Aubrey continued in that career till he got exposed to something much more demanding. "I started programming, and I thought that one of the biggest problems the world faces is that people have to spend so much of their time doing stuff that they wouldn’t do unless they were being paid for it – I’ll stop that by helping in artificial intelligence research to create more automation. ” Learn why Aubrey chose to switch fields back in 1990 and pursue a career that could ultimately fulfil his desire of being able to make as big of a difference to the world as possible. "Having found out that nobody was working on trying to keep people healthy late in life – not properly, anyway – I thought, what? I better switch fields, really? And that’s what led to my moving into the biology of aging back in the early 1990s. ” https://images.unsplash.com/photo-1566669437687-7040a6926753?ixlib=rb-1.2.1&ixid=eyJhcHBfaWQiOjEyMDd9&auto=format&fit=crop&w=667&q=80 Raising Awareness and Concern about the Process of Aging Our guest is the person who played a key role in the introduction and spreading of this revolutionary idea in the field of gerontology – a switch from making efforts for the prevention of ‘aging’ to making efforts for the remediation of the process called ‘aging.’ "I was fortunate enough to have a few ideas in the late 90s that were quite well received, so I rose to great prominence in gerontology very quickly. In the year 2000, I had the idea that comprehensive damage repair is the most promising and practical way to keep people healthy late in life. ” "My goal is and has always been to grow this movement to a point that I become unnecessary, that there are people in the field who are better than me. And then I will retreat into glorious obscurity. ” https://images.unsplash.com/photo-1519171920866-a020bf47357b?ixlib=rb-1.2.1&ixid=eyJhcHBfaWQiOjEyMDd9&auto=format&fit=crop&w=750&q=80 A New Concept in Gerontology It took him much and more to make people realize that not only do they want to live, but they also want to live long and live healthy – that eventually leads to the idea that they want to defeat the biologically deteriorative process called aging. "If it’s all about simple health care and if one recognizes that longevity is simply a side effect of not getting sick, then the argument becomes a great deal easier to make. ” Learn why defeating aging is more about reducing the combined effect of time on biological systems than trying to prevent that effect from occurring at all. "The most common sense and most practical approach to keeping people healthy late in life was simply to repair the damage that the body does to itself throughout life, not necessarily perfectly, but well enough so that the overall amount of damage that remains in the body is within the capacity of the body to tolerate. ” https://images.unsplash.com/photo-1505682614136-0a12f9f7beea?ixlib=rb-1.2.1&auto=format&fit=crop&w=751&q=80 Striving for the Cause Aubrey has contributed much and more to the spreading of awareness about all these concepts because that is how the scientists can motivate people from all domains to donate and contribute to the progress of research that eventually benefits the whole of mankind. "If you’re working on something that is interesting and important, it’s not such a problem to get people to come and work for you.” https://images.unsplash.com/photo-1522211988038-6fcbb8c12c7e?ixlib=rb-1.2.1&ixid=eyJhcHBfaWQiOjEyMDd9&auto=format&fit=crop&w=750&q=80 Having an Understanding in Multiple Fields Learn how switching fields is one of the most innovative and productive things that can happen in one’s career. It opened a whole new dimension for Aubrey, and it also allows for a profitable transfer of skill sets from one domain to another. "It’s quite clear that when people switch fields, they very often do really good things in the new field because they’ve got the skill set to work on really hard problems because of their transferable skill, but they’re not encumbered by the conventional wisdom that everybody else in the field have.” https://images.unsplash.com/photo-1546188994-07c34f6e5e1b?ixlib=rb-1.2.1&ixid=eyJhcHBfaWQiOjEyMDd9&auto=format&fit=crop&w=751&q=80 Hope for the Future Aubrey has high hopes for the future of gerontology and welcomes any feedback or help that people have to offer him on his way to the achievement of these universal goals. "I think within the next 10 years, we will have reached the threshold of research that I historically have called robust master rejuvenation. It’s only a matter of time before we can bring aging under comprehensive medical control.” He also believes that only a collective effort can uproot the problem altogether. "I believe that at the end of the day, this problem of aging will not be solved by one person or one organization. It will be a collective effort because it should divide and conquer approach.” https://images.unsplash.com/photo-1478796415026-3c85ee65975e?ixlib=rb-1.2.1&ixid=eyJhcHBfaWQiOjEyMDd9&auto=format&fit=crop&w=750&q=80 Moving Forward Aubrey is trying to get people to move past all the obstacles that are stopping them from being concerned about aging. Any contribution to the movement that he has initiated is much appreciated. "It’s all about past people’s fear of getting their hopes up and knowing that people have been wrong about the defeat of aging right through the history of civilization.” Subscribe! If you enjoyed the podcast please subscribe and rate it. And of course, share with your friends! Special Guest: Aubrey De Grey.

This episode will take you through Dr. Aubrey de Grey’s Seven Pillars of aging, the research that he's currently doing, his opinion on biological age, AGEs and the different sources, and the impact of growth hormone on biological age.Who is Dr. Aubrey de Grey?Aubrey de Grey is an English author and biomedical gerontologist. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics, Inc.He is the editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging and co-author of Ending Aging. He is known for his view that medical technology may enable human beings alive today not to die from age-related causes.He is also an amateur mathematician who has contributed to the study of the Hadwiger–Nelson problem.His research focuses on whether regenerative medicine can prevent the aging process. He works on the development of what he calls "Strategies for Engineered Negligible Senescence" (SENS), a collection of proposed techniques to rejuvenate the human body and stop aging. To this end, he has identified seven types of molecular and cellular damage caused by essential metabolic processes. SENS is a proposed panel of therapies designed to repair this damage. De Grey is an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies.He has been interviewed in recent years in a number of news sources, including CBS 60 Minutes, the BBC, The New York Times, Fortune Magazine, The Washington Post, TED, Popular Science, The Colbert Report, Time, the Skeptics' Guide to the Universe, and The Joe Rogan Experience. He is also a member of Flooved advisory board.Highlights[1:57] Where are we in the battle against aging?[4:29] Dr. de Grey explains the seven aspects of aging[8:38] Effects of lifestyle on the AGEs and aging[12:23] Measures for biological age[18:07] Why haven’t we evolved past aging?[20:28] Alzheimers, cancer and cardiovascular disease as components of aging[24:44] Transitioning from computer science to gerontology[27:53] Dr. de Grey answers the Superhuman sixResourcesThe Health Optimisation SummitHorvath’s Epigenetic clockReversing Biological Age by Greg FahyEnding Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our LifetimeOur sponsor today is CAR.O.L You don’t have time for that 45 minute jog.You need something fast, efficient, and leaves you wanting more. My favorite tool for this is the CAR.O.L. She is a life-changing bike, that provides you all the endurance you need into two 20 second bursts. Yes, you read that right. That’s 40 seconds of max-effort, including the warm up and cool downs, you get a kick-ass workout in 8 minutes and 40 seconds. The CAR.O.L is a resistance bike powered by artificial intelligence, which personalizes and optimizes the resistance, so you hit your maximum intensity levels and maximize glycogen depletion every single time. The proof is really in the pudding. CAR.O.L’s effectiveness was independently verified by the American Council on Exercise. I gave the CAR.O.L bike spin at Health Optimization Summit in London this year, and she kicked my ass so much that I had to get one. Check out CAR.O.L at carolfitai.com If you have limited time and want an amazing workout, which basically everyone that listens to this show does, use the code DECODING150 for a big discount, head over to CarolfitAI.com to secure yours.Continue Your High Performance Journey with Dr. de GreyWebsiteTwitterDisclaimer This information is being provided to you for educational and informational purposes only. This is being provided as a self-help tool to help you understand your genetics, biodata and other information to enhance your performance. It is not medical or psychological advice. Virtuosity LLC, or Decoding Superhuman, is not a doctor. Virtuosity LLC is not treating, preventing, healing, or diagnosing disease. This information is to be used at your own risk based on your own judgment. For the full Disclaimer, please go to (Decodingsuperhuman.com/disclaimer). See acast.com/privacy for privacy and opt-out information.

Today we explore human longevity and life extension efforts focused on adding healthy years to a person's lifespan, and even reversing the aging process.   My guest is Dr. Aubrey de Grey, a leading voice in the field and the Chief Science Officer of the SENS Research Foundation which is doing pioneering work on significantly extending healthy, active lifespans. Aubrey is a biomedical gerontologist with a degree in Computer Science and a Ph.D. in Biology. He is author of the book "Ending Aging" and Editor-in-Chief of the scientific journal "Rejuvenation Research".   Aubrey sees life extension as a side effect of his efforts to make people healthier, and sees no inherent limit to how far this could ultimately extend. We explore such concepts the "pro aging trance", "longevity escape velocity" and "comprehensive damage repair" that can sustain a human body.   More on Aubrey and the SENS Research Foundation: https://www.sens.org   More at: https://www.MindAndMachine.io

Today's Flash Back Friday comes from Episode 106, originally published in September 2012. Dr. Aubrey de Grey, a biomedical gerontologist, joins Jason Hartman on this episode to discuss how close we're getting to finding the proverbial Fountain of Youth. Dr. de Grey explains that the aging process is simply the collection of early stages of the illusion of old age, i.e. cell damage and loss. He said the accumulation of aging side effects leads to the diseases and conditions of old age that we do not notice during younger ages. He describes the human body as a machine, albeit a very complicated and complex machine, and therefore, it should come as no surprise that the body breaks down over time. Dr. de Grey and the SENS Foundation have a plan to repair various areas of cell damage and cell loss through processes such as stem cell replacement therapies to slow the aging process. Dr. de Grey talks about the science, the research, the obstacles and the funding of this important work. He assures us that once this work is up and running, it will be the real deal allowing people to look and feel younger, but he stresses that this would be preventative care. Jason and Dr. de Grey also address the implications of slowing the aging process on the world population, the age to which people continue to work, pensions, and our carbon footprint. Dr. Aubrey de Grey is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, USA, and is the Chief Science Officer of SENS Foundation, a California-based 501(c)(3) charity dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world's highest-impact peer-reviewed journal focused on intervention in aging. He received his BA and Ph.D. from the University of Cambridge in 1985 and 2000 respectively. His original field was computer science, and he did research in the private sector for six years in the area of software verification before switching to biogerontology in the mid-1990s. His research interests encompass the characterisation of all the accumulating and eventually pathogenic molecular and cellular side-effects of metabolism (“damage”) that constitute mammalian aging and the design of interventions to repair and/or obviate that damage. He has developed a possibly comprehensive plan for such repair, termed Strategies for Engineered Negligible Senescence (SENS), which breaks aging down into seven major classes of damage and identifies detailed approaches to addressing each one. A key aspect of SENS is that it can potentially extend healthy lifespan without limit, even though these repair processes will probably never be perfect, as the repair only needs to approach perfection rapidly enough to keep the overall level of damage below pathogenic levels. Dr. de Grey has termed this required rate of improvement of repair therapies “longevity escape velocity”. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations. Website: www.SENS.org

Are you interested in space travel, genetic engineering and other futurist tech trends transforming our world/society? If so you will love this.Our Expert Panelists:Aubrey de Grey is a Cambridge researcher and Chief Science Officer of SENS Research Foundation focused on aging and extending human longevity. He proposes that the first human beings who will live to 1,000 years old have already been born. In addition to his research, Aubrey is editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging(2007). De Grey’s research focuses on whether regenerative medicine can prevent the aging process. He works on the development of what he calls “Strategies for Engineered Negligible Senescence” (SENS), a collection of proposed techniques to rejuvenate the human body and stop aging. To this end, he has identified seven types of molecular and cellular damage caused by essential metabolic processes. SENS is a proposed panel of therapies designed to repair this damage.Mike Selden is co-founder and CEO of Finless Foods, a food startup that uses cutting-edge cellular-agriculture technologies to grow marine-animal cells, creating fish and seafood products enjoyed around the world. They are working toward a sci-fi, soon-here world where everyone has access to healthy, delectable seafood, without the environmental devastation or the health hazards of traditional fishing and aquatic farming.Jenny Rooke is the founder and managing partner or Genoa Ventures (formerly 5 Prime Ventures) where she funds and builds companies that change the way science gets done with new tools and technologies. She has a PhD in Genetics, a Bachelors in physics, and a background in computer science and works closely with early-stage life science start-ups on issues of fundraising, market and product strategy, and business development.We cover a wide range of topics from genetic engineering and human longevity to personalized medicine, pharma, manufactured meats and much more...You can listen right here on iTunes--Make a Tax-Deductible Donation to Support FringeFMFringeFM is supported by the generosity of its readers and listeners. If you find our work valuable, please consider supporting us on Patreon, via Paypal or with DonorBox powered by Stripe.Donate

Aubrey de Grey (@aubreydegrey) is Cambridge researcher and Chief Science Officer of SENS Research Foundation focused on aging and extending human longevity. He proposes that the first human beings who will live to 1,000 years old have already been born. In addition to his research, Aubrey is editor-in-chief of the academic journal Rejuvenation Research, author of... The post FringeFM 18 – Aubrey de Grey on the End of Aging, Increased Human Longevity and Living to 1000 Years appeared first on The Syndicate.

CliffCentral.com — “People in middle age now have a fair chance” - that’s what Dr Aubrey de Grey believes as he continues to work towards finding the cure to ageing. As the Editor-in-Chief of Rejuvenation Research, Fellow of both the Gerontological Society of America and the American Ageing Association, Dr de Grey is also perhaps the world’s foremost advocate of the provocative view that medical technology will one day allow humans to control the ageing process and live healthily into our hundreds - or even thousands. Gareth Cliff dives into his mind to find out more. The 200 Year Old

Aubrey de Grey (@aubreydegrey) is Cambridge researcher and Chief Science Officer of SENS Research Foundation focused on aging and extending human longevity. He proposes that the first human beings who will live to 1,000 years old have already been born.In addition to his research, Aubrey is editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007).  De Grey's research focuses on whether regenerative medicine can prevent the aging process. He works on the development of what he calls "Strategies for Engineered Negligible Senescence" (SENS), a collection of proposed techniques to rejuvenate the human body and stop aging. To this end, he has identified seven types of molecular and cellular damage caused by essential metabolic processes. SENS is a proposed panel of therapies designed to repair this damage.He has been interviewed by most major news sources, including CBS 60 Minutes, the BBC, The New York Times, Fortune Magazine, The Washington Post, TED, Popular Science, The Colbert Report, Time and the Skeptics' Guide to the Universe.You can listen right here on iTunesIn our wide-ranging conversation, we cover many things, including: * Why Aubrey switched from studying AI to the science of human longevity * The causes of aging and how we can "cure" them * Why prevention is orders of magnitude more effective than intervention * The reason Aubrey believes some humans today will live to be 1000 years old * Why there isn't enough funding or support currently for fighting aging * The reason stem cell research is progressing rapidly and proving fruitful * How caloric restriction effects metabolism and aging * Why SENS often spins out businesses to further their aims * The science of immortality * How mainstream media has reacted to prospect of increasing lifespanTranscriptProducing this podcast and transcribing the episode takes tons of time and resources. If you support FringeFM and the work we do, please consider making a tax-deductible donation. If you can’t afford to support us, we completely understand as well, but an iTunes review or share on Twitter can go a long way too! AUBREY DE GREY:  Well I do think it’s very probable. In fact, I think it’s quite likely that the first person to live to a thousand is already in their forties or fifties—or, and perhaps even older.  So the question is, “Why do I think that?” And a lot of people misunderstand this. Some people think that the reason I’m saying this is because I think that we are within a small number of decades of developing therapies that completely, one hundred percent eliminate aging by repairing every single aspect of the damage that the body accumulates as  a side effect of its normal operation. I don’t say that at all. I never have, and I never shall.  MATT:  Survival of the fittest—Darwin realized evolution is merely the process of survival.  Nothing has been more driving a force as survival. Nothing wants to die. I don’t want to die.  You don’t want to die—even if you’ve accepted death. When there’s a way around it, we would give anything.  Today we’ve got Aubrey de Grey. Aubrey’s the Cambridge researcher and chief science officer of th...

In this episode of the OPP I talk with Dr. Michael Fossel.  We have an amazing conversation about longevity, a possible cure for Alzheimers and other cognitive degenerative diseases.  Dr. Fossel is the author of The Telomorase Revolution and is the founder and former Editor in Chief of Rejuvenation Research. He's best known best for his views on telomerase therapy as a possible treatment for cellular senescence in human age related disease.  Our conversation moves really quickly, and I get to ask how we include our longevity, his stack, personal work, and the potential for human trials into the reversal of Alzheimers. Alzheimers is brutal and this is pretty big stuff. Outline Intro [2:30] How does aging happen? [05:40] What is telomerase? [8:00] What are you working on now? [9:45] What would a treatment reversing Alzheimers look like? [12:00] What are we looking at in terms of increased lifespan? [15:45] Are there any diseases that can't be reversed through therapy? [18:30] Length vs Relative Length of Telomeres [21:15] Telomere testing and efficacy [25:00] Supplements helping with brain efficiency [31:00] Stem cell and gene therapy [36:30] What drew you into this line of work? [41:00] Longevity goals [45:15] How does cannabis fit into longevity? [53:00] The future of telomerase [55:30] Outro [57:15] Links & Resources The Telomerase Revolution Cellular senescence Connect With Us Follow Sean McCormick Instagram: http://bit.ly/OPPMacTwitter: http://bit.ly/OPPMacTwitter Follow Natural Stacks Twitter: http://bit.ly/NsTwitterInstagram: http://bit.ly/NsInstagram Facebook: http://bit.ly/NsFacebook Shop Natural Stacks Shop: http://bit.ly/OPPShop

Dr. Gregory Fahy is a cryobiologist and biogerontologist. He’s credited with a many of the breakthroughs in cryopreservation, and he has been working on finding new ways to use already-approved drugs. Fahy talks about his work with human growth hormone (HGH) and shares the highlights of the results of his first human trials with it. He talks about what happens around age 62-65 for most people that rapidly increases chances of death. Fahy urges people interested in longevity to pay attention to what is on the cutting edge of medicine, he stresses the importance of nicotinamide adenine dinucleotide (NAD) in staying youthful, and he believes there is a profound connection between the immune system and aging. Also on the podcast, Mark explains what he means when he says Americans are eating like we’re on death row. Dr. Gladden expands on HGH and considers some of the drawbacks and complications that could occur when it is used as treatment. In This Week in Longevity Science, they discuss peptides as a form of treatment, including how they function in the body and their promising regenerative properties. Research is being done to see how well peptides could work for highly customized medicine, not only for a specific disease but the exact disease within the individual.    Ask yourself, “How am I going to learn more about this cutting-edge science in order to change the trajectory of my aging?” About the Guest: Gregory M. Fahy, Ph.D. Dr. Fahy earned his B.S. from the University of California at Irvine in 1972 and his Ph.D. from the Medical College of Georgia in 1977 for work on basic aspects of cryobiology. He spent the next 18 years developing methods for preserving whole organs at cryogenic temperatures at the American Red Cross in Maryland. In 1980, he conceived of preserving organs by vitrification. He published the first proof of principle of this concept in Nature in 1985 using mouse embryos as a model system, an event that led to the wide use of vitrification in academic and commercial animal husbandry as well as in human assisted reproduction.   In 1995, he won the Grand Prize for Medicine from INPEX for his invention of the first effective computer-operated equipment for perfusing organs with cryoprotective agents. The same year, he left the Red Cross to become Chief Scientist of two biotechnology companies and the Head of the Tissue Cryopreservation Section of the Transfusion and Cryopreservation Research Program at the Naval Medical Research Institute in Bethesda, Maryland. In 1998, he became the Chief Scientific Officer and Vice President of 21st Century Medicine, where he invented several new principles in cryopreservation that have been extraordinarily effective in practical applications ranging from tissues to whole organs.   Dr. Fahy’s efforts have recently raised the question of whether human suspended animation might be an attainable goal that could allow the human species to survive in deep time as a result of enabling migration from the earth to other habitats in the cosmos. Dr. Fahy is a sought-after speaker and problem-solver. He is on the Board of Directors of several organizations concerned with cryopreservation or aging, serves on the Editorial Board of Rejuvenation Research, and has served as a reviewer for numerous journals and granting bodies. He has over 20 patents in fields related to cryopreservation, aging, transplantation, metabolic protection, and the reversal of autoimmunity and immunosenescence, and has many publications in the fields of cryobiology, aging, and nanotechnology. He currently serves as Director for Intervene Immune, Inc. Learn more about the projects they are working on and how to become a part of their clinical trials at http://interveneimmune.com/.

Curing Alzheimer’s and The Telomerase Revolution with Dr. Michael FosselDr. Michael Fossel earned both his PhD and MD from Stanford University, where he taught neurobiology and research methods. Winner of a National Science Foundation fellowship, he was a clinical professor of medicine for almost three decades, the executive director of the American Aging Association, and the founding editor of Rejuvenation Research. He currently teaches The Biology of Aging at Grand Valley State University. www.MichaelFossel.com

Phil and Stephen continue their discussion with Dr. Aubrey de Grey, reviewing some of the very encouraging life extension research currently taking place How does the treatment of other conditions (cancer, diabetes, obesity, heart disease, etc) ultimately contribute to the first generation of anti-aging medicine?Will devices such as those created for the Qualcomm Tricorder X Prize be a game-changer for treating aging? What role will CRISPR technology play in helping us to live longer?Metformin -- miracle youth drug or a lot of hype?Of the seven kinds of cell damage that constitute aging, which are we gaining on with the current research?And which is the most challenging? About Our Guest: Dr. Aubrey de Grey is a biomedical gerontologist who researched the idea for and founded the SENS Research Foundation. SENS stands for “Strategies for Engineered Negligible Senescence,” an idea that Aubrey outlined in his 2007 book, Ending Aging. Aubrey has a BA in Computer Science and a Ph.D. in Biology from the University of Cambridge. He is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations. He is also a contributor to our book Visions for a World Transformed. WT 327-636

Phil and Stephen welcome life extension researcher and visionary Dr. Aubrey de Grey to discuss the sometimes puzzlingly negative views much of the public seem to have about efforts to fight aging. Topics: A question Aubrey raises in Visions for a World Transformed:  What possesses people to defend the existence of the phenomenon that is far and away the most likely thing to kill them – and not only that, but to do so slowly and painfully? How is it that the elderly are themselves guilty of ageism? Glenn Reynolds in USA Today What is the pro-aging trance? Methuselah Mouse project as proof of concept for fighting aging Is life extension becoming more mainstream?  Is the first human being who will live to the age of 1,000 already among us? About Our Guest: Dr. Aubrey de Grey is a biomedical gerontologist who researched the idea for and founded the SENS Research Foundation. SENS stands for “Strategies for Engineered Negligible Senescence,” an idea that Aubrey outlined in his 2007 book, Ending Aging. Aubrey has a BA in Computer Science and a Ph.D. in Biology from the University of Cambridge. He is Editor-in-Chief of Rejuvenation Research, is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organizations. He is also a contributor to our book Visions for a World Transformed. WT 326-635  

Dr. Aubrey de Grey is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, USA. He is the Chief Science Officer of SENS Research Foundation, a California-based biomedical research charity that performs and funds laboratory research dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world's highest-impact peer-reviewed journal focused on intervention in aging. On today's episode of Bulletproof Radio, Dave and Aubrey talk about the seven things that cause aging, morbidity, the ethics of immortality, fighting cancer, aging goals for the immediate future and more. Enjoy the show!

Dr. Aubrey de Grey is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, USA. He is the Chief Science Officer of SENS Research Foundation, a California-based biomedical research charity that performs and funds laboratory research dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world's highest-impact peer-reviewed journal focused on intervention in aging. On today's episode of Bulletproof Radio, Dave and Aubrey talk about the seven things that cause aging, morbidity, the ethics of immortality, fighting cancer, aging goals for the immediate future and more. Enjoy the show!

Dr. Aubrey de Grey is a biomedical gerontologist who is the Chief Science Officer and Cofounder of SENS Research Foundation found at Sens.org. They work to extend the lifespan significantly. They believe the first person that will live to 1000 is alive today. He received a degree in  Computer Science and Ph.D. in Biology from the University of Cambridge. Dr. de Grey is Editor-in-Chief of Rejuvenation Research  and sits on numerous scientific advisory boards and journals. He is the author of  “Ending Aging”.   http://www.inspiredinsider.com/aubrey-de-grey-endaging-interview/  

Aubrey de Grey, PhD, is a biomedical gerontologist and Chairman and Chief Science Officer of The Methuselah Foundation. His major research interests are the role and etiology of all forms of cellular and molecular damage in mammalian aging, and the design of interventions to reverse the age-related accumulation of such damage. He has published extensively on these and other areas of gerontology, and is also Editor-in-Chief of Rejuvenation Research, the only peer-reviewed academic journal focusing on intervention in aging. He is the organiser of an ongoing series of conferences and workshops that focus on the key biomedical research relevant to SENS, and he also oversees the Methuselah Foundation's growing sponsorship of SENS research worldwide.In this conversation with D.J. Grothe, Aubrey de Grey explains aging, and the SENS (Strategies for Engineered Negligible Senescence) program that seeks to reverse aging in our lifetime. He explains how his work is, and is not, continuous with "transhumanism." He addresses challenges the medical and scientific establishment have brought against his work, and how his project is different than the quackery so widespread in the anti-aging movement. He also discusses some of the social and existential problems that ending aging may create for our civilization.