Podcasts about Molecular biology

Synopsis: What do courtroom litigation, computational biology, and fibrosis drug development have in common? In this episode of Biotech 2050, host Alok Tayi speaks with Ahmed Mousa, CEO of Vicore Pharma, to explore his unconventional journey from biotech law to the C-suite. Ahmed shares how Vicore is advancing a first-in-class therapy targeting the angiotensin II type 2 receptor to treat idiopathic pulmonary fibrosis (IPF)—a devastating disease with limited options and poor survival. The conversation dives into how AI is reshaping drug discovery, the promise of precision in early-stage candidate design, and the regulatory and data challenges biotech must overcome. Ahmed also reflects on leading a Swedish-listed biotech as an American CEO, and how a patient-first mission continues to fuel bold innovation across continents. Biography: Ahmed Mousa is the Chief Executive Officer of Vicore Pharma (VICO.ST), where he leads the company's mission to advance angiotensin II type 2 receptor agonists for the treatment of idiopathic pulmonary fibrosis and other serious diseases. Under his leadership, Vicore continues to expand its clinical pipeline and global presence in respiratory and fibrotic diseases. Previously, Ahmed served as Senior Vice President, Chief Business Officer, and General Counsel at Pieris Pharmaceuticals (PIRS). In this role, he was the site head for the company's Boston office and oversaw business development, portfolio strategy, centralized project leadership, and quality assurance. He also led Pieris' legal and intellectual property functions, including licensing, corporate governance, and management of the company's global patent portfolio. Before joining Pieris, Ahmed was an attorney at Covington & Burling LLP, where he advised pharmaceutical and biotechnology companies on a range of regulatory and intellectual property matters. He also served as a law clerk for the U.S. Court of Appeals for the Third Circuit and began his legal career as an IP associate at Kirkland & Ellis LLP. Ahmed holds dual undergraduate degrees in Molecular Biology and Government from Cornell University, a Master's in Biotechnology from Johns Hopkins University, and a J.D. with honors from Georgetown Law, where he was Editor-in-Chief of the Georgetown Journal of International Law.

In this episode, Dr Joost Groen, a clinical biochemist at the University Medical Center Groningen, and Dr Matt Gentry, Professor & Chair of Biochemistry & Molecular Biology in the College of Medicine at University of Florida, join Rodrigo and Silvia to discuss new insights, AI, cancer metabolism and some of their favourite papers on Glycogen Storage Disorders. Authors opinions are their own and do not represent their institutions. GSD episode papers: Brain glycogen serves as a critical glucosamine cache required for protein glycosylation. Sun et al A machine learning model accurately identifies glycogen storage disease Ia patients based on plasma acylcarnitine profiles. Groen et al Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders. Ullman et al Repurposing SGLT2 inhibitors: Treatment of renal proximal tubulopathy in Fanconi-Bickel syndrome with empagliflozin. Overduin et al Gross-Valle The relation between dietary polysaccharide intake and urinary excretion of tetraglucoside. Gross-Valle et al Glycogen drives tumour initiation and progression in lung adenocarcinoma. Clarke HA et al Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis. Conroy et al In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues. Young et al Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis. Brewer et al Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants. Rahman MS et al Neurological glycogen storage diseases and emerging therapeutics Colpaert et al

Dr. Jessica Rose is an artist, musician, mathematician, professional surfer, biologist, science researcher & data analysis. Dr. Rose has a Post Doc in Biochemistry at Technion Institute of Technology, Post Doc in Molecular Biology at Hebrew University of Jerusalem, PhD in Computational Biology at Bar-Ilan University, Master's in Medicine (Immunology) at Memorial University of Newfoundland, and BSc in Applied Mathematics at Memorial University of Newfoundland.DR. JESSICA ROSE:Twitter: https://twitter.com/JesslovesMJKSubStack: https://jessicar.substack.com/YouTube: https://www.youtube.com/channel/UC0EhWf2Vswdg7DwKKKZ34ngTHE RIPPLE EFFECT PODCAST:WEBSITE: http://TheRippleEffectPodcast.comWebsite Host & Video Distributor: https://ContentSafe.co/SUPPORT:PATREON: https://www.patreon.com/TheRippleEffectPodcastPayPal: https://www.PayPal.com/paypalme/RvTheory6VENMO: https://venmo.com/code?user_id=3625073915201071418&created=1663262894MERCH Store: http://www.TheRippleEffectPodcastMerch.comMUSIC: https://music.apple.com/us/album/the-ripple-effect-ep/1057436436SPONSORS:OPUS A.I. Clip Creator: https://www.opus.pro/?via=RickyVarandasUniversity of Reason-Autonomy: https://www.universityofreason.com/a/2147825829/ouiRXFoL WATCH:RUMBLE: https://rumble.com/c/therippleeffectpodcastBANNED.VIDEO: https://banned.video/channel/the-ripple-effect-podcastOFFICIAL YOUTUBE: https://www.youtube.com/@TheRippleEffectPodcastOFFICIALYOUTUBE CLIPS CHANNEL: https://www.youtube.com/@RickyVarandasTikTok: https://www.tiktok.com/@ricky.varandasLISTEN:SPOTIFY: https://open.spotify.com/show/4lpFhHI6CqdZKW0QDyOicJiTUNES: http://apple.co/1xjWmlFPodOmatic: https://www.podomatic.com/podcasts/rvtheory6CONNECT:TeleGram: https://t.me/TREpodcastX: https://x.com/RvTheory6IG: https://www.instagram.com/rvtheory6/ FB: https://www.facebook.com/TheRippleEffectPodcast/THE UNION OF THE UNWANTED: https://linktr.ee/TheUnionOfTheUnwanted

In this episode of the Epigenetics Podcast, we talked with Sarah Teichmann from the University of Cambridge about the Human Cell Atlas. In the Interview we explore Sarah Teichmann's impressive career trajectory, covering her current role as Chair of Stem Cell Medicine at the Cambridge Stem Cell Institute and Vice President of Translational Research at GlaxoSmithKline. Professor Teichmann explains her unique dual appointments, a rare arrangement that allows her to bridge academia and industry effectively. As the conversation shifts focus to computational biology, she takes us on a historical journey from her PhD work at the MRC Laboratory of Molecular Biology to the present advancements driven by next-generation sequencing and artificial intelligence methods. Professor Teichmann emphasizes that the landscape of biological research has evolved significantly, particularly in the realm of data-driven methodologies. The conversation then transitions seamlessly into her pivotal role in advancing single-cell genomics, where she discusses the motivation behind using single-cell RNA sequencing methods in her research on T cells. This technique offered unmatched insights compared to bulk sequencing techniques, allowing for a more detailed understanding of cell states and their complex interactions within tissues. A highlight of the episode is Professor Teichmann's insights on the Human Cell Atlas project, which she co-founded in 2017. She elaborates on the ambitious vision to map all human cells, likening the endeavor to the Human Genome Project. Through the atlas, researchers aim to create a detailed reference map that facilitates a deeper understanding of human health and disease. Professor Teichmann shares the collaborative efforts that led to its inception and the importance of international cooperation in scientific research. The discussion culminates with an exploration of the biggest scientific findings thus far from the Human Cell Atlas. Among the revelations, she notes the astounding complexity and diversity of cell types identified, particularly within the immune system, and the unexpected locations of certain cell types during human development. She also highlights significant discoveries related to COVID-19, demonstrating the immediate real-world impact of their work.   References https://www.humancellatlas.org The Human Cell Atlas: towards a first draft atlas Kock, K. H., Tan, L. M., Han, K. Y., Ando, Y., Jevapatarakul, D., Chatterjee, A., Lin, Q. X. X., Buyamin, E. V., Sonthalia, R., Rajagopalan, D., Tomofuji, Y., Sankaran, S., Park, M. S., Abe, M., Chantaraamporn, J., Furukawa, S., Ghosh, S., Inoue, G., Kojima, M., Kouno, T., … Prabhakar, S. (2025). Asian diversity in human immune cells. Cell, 188(8), 2288–2306.e24. https://doi.org/10.1016/j.cell.2025.02.017   Related Episodes The Discovery of Genomic Imprinting (Azim Surani)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Historians have floated a half-dozen theories for why Viking Greenland settlements suddenly vanished in the 1300s and 1400s, after nearly 500 years of occupation. Was it climate change, the Black Death, even bad farming habits learned in Scandinavia?But what if…it all came down to walrus ivory? It turns out that walrus tusks during the Viking and Middle Ages fuelled a long-distance trade network that stretched from Inuit hunters far above the Arctic Circle to churches and royalty in cities as far flung as Novgorod, Kyiv and Cologne. Now, using ancient DNA and isotope analysis, archaeologists have shown that virtually all these tusks came from Greenland!And then suddenly, the market collapsed. What happened?Today's show looks at how everything from cutting edge technology to dogged footwork has allowed researchers to piece together the details of the global walrus trade a thousand years back in time. They're also using this window into the past to better understand walruses themselves, to make predictions about the future of walruses in a warming world.My guests on today's show are James Barrett, professor of medieval and environmental archaeology at the NTNU University Museum, and Katrien Dierickx and Erin Kunisch, postdocs with James and the 4-Oceans project.Here's a link to the NTNU University Museum's new exhibit on the walrus tusk trade, Sea Ivories. The exhibition includes the Wingfield-Digby Crozier, from the Victoria & Albert Museum, plus several Lewis Chessmen, from the British Museum.Here's a link to photos and a description of a Romanesque walrus ivory carving, the Cloisters Cross. Here's a link to a Gothic-style carving of elephant ivory.Here are some relevant academic articles:Barrett, James; Boessenkool, Sanne; Kneale, Catherine; O'Connell, Tamsin C; Star, Bastiaan. (2020) Ecological globalisation, serial depletion and the medieval trade of walrus rostra. Quaternary Science ReviewsBarrett, James; Khamaiko, Natalia; Ferrari, Giada; Cuevas, Angelica; Kneale, Catherine; Hufthammer, Anne Karin. (2022) Walruses on the Dnieper: new evidence for the intercontinental trade of Greenlandic ivory in the Middle Ages. Proceedings of the Royal Society of London. Biological SciencesKeighley, X et al.Disappearance of Icelandic Walruses Coincided with Norse Settlement, Molecular Biology and Evolution, 36:12, Dec.2019, p2656–2667, https://doi.org/10.1093/molbev/msz196Transcript Hosted on Acast. See acast.com/privacy for more information.

Dr. Jessica Rose is an artist, musician, mathematician, professional surfer, biologist, science researcher & data analysis. Dr. Rose has a Post Doc in Biochemistry at Technion Institute of Technology, Post Doc in Molecular Biology at Hebrew University of Jerusalem, PhD in Computational Biology at Bar-Ilan University, Master's in Medicine (Immunology) at Memorial University of Newfoundland, and BSc in Applied Mathematics at Memorial University of Newfoundland.DR. JESSICA ROSE:Twitter: https://twitter.com/JesslovesMJKSubStack: https://jessicar.substack.com/YouTube: https://www.youtube.com/channel/UC0EhWf2Vswdg7DwKKKZ34ngTHE RIPPLE EFFECT PODCAST:WEBSITE: http://TheRippleEffectPodcast.comWebsite Host & Video Distributor: https://ContentSafe.co/SUPPORT:PATREON: https://www.patreon.com/TheRippleEffectPodcastPayPal: https://www.PayPal.com/paypalme/RvTheory6VENMO: https://venmo.com/code?user_id=3625073915201071418&created=1663262894MERCH Store: http://www.TheRippleEffectPodcastMerch.comMUSIC: https://music.apple.com/us/album/the-ripple-effect-ep/1057436436SPONSORS:OPUS A.I. Clip Creator: https://www.opus.pro/?via=RickyVarandasUniversity of Reason-Autonomy: https://www.universityofreason.com/a/2147825829/ouiRXFoL WATCH:RUMBLE: https://rumble.com/c/therippleeffectpodcastBANNED.VIDEO: https://banned.video/channel/the-ripple-effect-podcastOFFICIAL YOUTUBE: https://www.youtube.com/@TheRippleEffectPodcastOFFICIALYOUTUBE CLIPS CHANNEL: https://www.youtube.com/@RickyVarandasTikTok: https://www.tiktok.com/@ricky.varandasLISTEN:SPOTIFY: https://open.spotify.com/show/4lpFhHI6CqdZKW0QDyOicJiTUNES: http://apple.co/1xjWmlFPodOmatic: https://www.podomatic.com/podcasts/rvtheory6CONNECT:TeleGram: https://t.me/TREpodcastX: https://x.com/RvTheory6IG: https://www.instagram.com/rvtheory6/ FB: https://www.facebook.com/TheRippleEffectPodcast/THE UNION OF THE UNWANTED: https://linktr.ee/TheUnionOfTheUnwanted

In this episode of Speaking of Mol Bio, Dr. Beth Webb takes us deep into the world of platelets, often misunderstood components of blood that punch far above their weight in both physiological and pathological processes. As a postdoctoral researcher at the University of Leeds, Dr. Webb explores how endothelial signals influence platelet activity, and how these anucleate cell fragments play roles not only in clotting, but also in immune responses, inflammation, and diseases like cardiovascular disorders and COVID-19.Beth unpacks the technical challenges of isolating and analyzing platelets—particularly in RNA sequencing and qPCR—while stressing the importance of sample purity and the presence of platelet subpopulations. The conversation also touches on the hope of personalized medicine through platelet-based diagnostics and tailored antiplatelet therapies.Beyond the lab, Dr. Webb is an active science communicator, sharing tips on engaging broader audiences through social media, blogs, and video. She emphasizes the importance of resilience, creativity, and starting small when communicating science. Whether you're a cell biologist, a hematology enthusiast, or a fellow communicator, this episode offers something for everyone. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

Send us a textHow our biological clocks shape biology from the molecular to behavioral level.Episode Summary: Dr. Joseph Takahashi discusses circadian rhythms, exploring their biological basis, from molecular mechanisms to their impact on metabolism and health; the discovery of circadian clock genes; role of the suprachiasmatic nucleus, and how light, feeding, and oxygen influence these rhythms. The conversation highlights practical implications, such as the effects of artificial light and meal timing on health, and touches on emerging research linking stronger circadian clocks to longevity.About the guest: Joseph Takahashi, PhD is a renowned neuroscientist at UT Southwestern Medical Center, where he leads research on circadian clock genes.Discussion Points:The suprachiasmatic nucleus in the hypothalamus acts as the brain's central clock, syncing with light via the retina.Key circadian genes like CLOCK and BMAL regulate thousands of genes, especially those involved in metabolism, impacting health outcomes.Internal desynchronization, when brain and organ clocks misalign (e.g., from eating at night), can lead to metabolic issues like pre-diabetes.In mice, eating at the right time (night for nocturnal animals) extends lifespan by up to 35% under caloric restriction, compared to 10% with spread-out feeding.Artificial light, especially blue light at night, disrupts melatonin and circadian rhythms, while natural sunlight supports healthy eye development.Melatonin, a darkness-signaling hormone, is best for resetting rhythms (e.g., jet lag) at low doses, not as a sedative, and U.S. supplements vary widely in quality.Oxygen-sensing proteins interact with circadian clock components, hinting at links between altitude, metabolism, and health.Learning and memory show diurnal variations, with better performance at certain times, influenced by circadian modulation of synaptic activity.A stronger circadian clock, created genetically in mice, led to 16% longer lifespan and resistance to weight gain (unpublished research).Related episode:M&M 202: Why Do Animals Sleep? | Vlad Vyazovskiy*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Podcast Brought to You by Nutritious & Delicious https://ndelish.com/   In this episode, your host Bethany, a Certified Holistic Nutritional Consultant and previous Health Nurse, explores the profound impact of hormones on women's health with Rashida Aamir, a homeopathic practitioner with over 20 years of experience.   Rashida is a member of the Canadian Society of Homeopaths and holds a background in Cellular and Molecular Biology, allowing her to blend scientific insight with homeopathic expertise to support women dealing with complex hormonal issues like PCOS, endometriosis, and the effects of birth control.   Key Takeaways: · Common hormonal complications linked to birth control, both while taking it and after stopping. · Symptoms and hormonal imbalances often seen in women with PCOS and endometriosis, plus how these affect daily well-being. · Homeopathic solutions Rashida uses to restore hormonal balance for women dealing with these issues. · Insights into how long-term homeopathic care supports women in achieving more balanced hormones and improved quality of life.   Whether you're dealing with hormonal concerns or simply want to learn more about homeopathic approaches to hormone health, Rashida shares real-life examples and guidance to help women on their wellness journey.   More About Rashida Aamir: Website: https://acrowellness.ca Instagram: @acrowellness_homeopathy https://www.instagram.com/acrowellness_homeopathy/ Facebook: Acro Wellness https://www.facebook.com/acrowellness/ LinkedIn: Rashida Aamir https://www.linkedin.com/in/rashida-aamir/ TikTok: @acrowellness_homeopathy https://www.tiktok.com/@acrowellness_homeopathy     Are you ready to take control of your nutrition and well-being? Nutritious & Delicious offers customized holistic nutrition consultations to help you on your health journey.  Book a 1-hour consultation with Bethany today and start your transformation!  https://calendly.com/ndelish/60min

Send us a textCellular self-organization, cytoskeleton dynamics, and membrane wound healing.Episode Summary: Cell Biologist Dr. Bill Bement explains the dynamic world of the cell cortex, discussing how actin filaments and microtubules drive processes like cell division and wound healing through self-assembly and self-organization; energy dynamics of these processes; the role of rho GTPases in patterning; the implications for diseases such as cancer and muscular dystrophy, using vivid analogies and video demonstrations to make complex concepts accessible.About the guest: Bill Bement, PhD is a cell biology professor at the University of Wisconsin-Madison, where he has studied cellular processes for over 30 years. He leads a lab focused on the cell cortex, investigating cell division and repair. His work emphasizes self-organization and cytoskeletal dynamics, contributing to insights into diseases like muscular dystrophy.Discussion Points:The cell cortex, the outer layer of a cell, includes the plasma membrane & underlying proteins like actin & myosin, which enable dynamic shape changes.Actin filaments self-assemble without energy input, growing & shrinking to facilitate cell movement and division, while microtubules, stiffer hollow tubes, aid in chromosome separation.Self-organization in cells, driven by energy-dependent feedback loops, creates complex patterns like mitotic spindles.Cellular wound healing involves concentric rings of rho GTPases and actin, closing wounds rapidly, a process critical for surviving natural damage from mechanical stress or toxins.Energy costs of cytoskeletal rearrangements are significant but likely less than protein synthesis, though precise measurements remain challenging.Cancer metastasis may rely on enhanced cell repair, allowing metastatic cells to survive mechanical damage while squeezing through tissues.Muscular dystrophy involves excessive damage or impaired repair, highlighting the importance of cell repair mechanisms.Bement's lab is developing tools for synthetic self-organization, aiming to manipulate cellular processes to address repair deficits in diseases.Related episode:M&M 220: Cell Death, Oxidative Stress, PUFAs & Antioxidants | Pamela Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Welcome back to the WellFuel Podcast with your host, Isabel Smith!We're excited to bring you a truly special episode this week - one that's been long-awaited by our community. Isabel is opening up about her personal journey with Long COVID, Lyme, and co-infections, and the unconventional path she took to find relief.After her own battle with COVID-19 and a resurgence of chronic symptoms, Isabel teamed up with a specialist to explore a unique approach: using a nicotine patch to help reduce viral loads and free up ACE2 receptors. Whether you or someone you love is dealing with Long COVID, chronic illness, or just curious about innovative healing protocols, this episode is packed with valuable insights and real-life experience.Isabel's story is raw, honest, and full of hope. We hope it inspires you to keep searching for answers and reminds you that you're not alone in your healing journey.Tune in now to hear the full episode - and don't forget to share it with anyone who might benefit from Isabel's experience and insights!---------------------------EPISODE HIGHLIGHTS: The backstory of Isabel's struggle with Lyme and Long COVIDWhy she considered the nicotine patch protocol - and how it worksHonest reflections on the symptoms, challenges, and adjustments she faced along the wayThe supplements and strategies that supported her two-month journeyInsightful commentary on the results she achieved and what this could mean for others facing similar chronic conditions--------------------------CHAPTERS: 00:00 – Welcome to the WellFuel Podcast00:24 – My Journey with Lyme and Long COVID01:20 – The Nicotine Patch Protocol03:40 – Experiencing the Nicotine Patch04:53 – Symptom Log and Supplementation06:27 – Challenges and Adjustments10:06 – Final Thoughts and Future Plans-----------------------------HELPFUL DEFINITIONS: ACE2 Receptors: ACE2 is a protein on the surface of many cell types. It is an enzyme that generates small proteins – by cutting up the larger protein angiotensinogen – that then go on to regulate functions in the cell.Using the spike-like protein on its surface, the SARS-CoV-2 virus binds to ACE2 – like a key being inserted into a lock – prior to entry and infection of cells. Hence, ACE2 acts as a cellular doorway – a receptor – for the virus that causes COVID-19.Lumbrokinase: Lumbrokinase is known for its ability to dissolve fibrin, which is a crucial component of blood clots. This ability makes it potentially useful in preventing and treating conditions related to excessive blood clotting. Nattokinase: Nattokinase is an enzyme that's extracted from natto, a traditional Japanese food made from fermented soybeans. Nattokinase is particularly known for its potential effects on blood circulation and blood clots.The Krebs Cycle: The Krebs cycle is used by organisms that generate energy via respiration, either anaerobically or aerobically (organisms that ferment use different pathways).M-Spike Protein: The M-spike, also known as monoclonal protein or paraprotein, is a marker in blood tests that indicates the presence of abnormal plasma cells.HRV: HRV, or Heart Rate Variability, refers to the variation in time between heartbeats. ---------------------LEARN MORE: The WellFuel Podcast explores gut health, detox, hormones, mold, and more—hosted by Isabel Smith, MS, RD, CDN. Join Isabel as she shares her insights and chats with experts from across the wellness spectrum, to help support you on the path to health and wellness.Learn more about Isabel Smith Nutrition: Visit Our WebsiteFollow along on social media:YouTube: @isabelsmithnutritionInstagram: @isabelsmithnutritionPinterest: @isabelsmithnutritionWant to learn more about how Isabel Smith Nutrition can help support you on your journey to better health? ⁠ Book a call with us today: Schedule Here---------------------------RESOURCES & REFERENCES: American Society for Biochemistry and Molecular Biology

In this Mol Bio Minutes episode, Laurynas Alijošius shares a personal story that every molecular biologist can relate to—running PCR, cloning, and sequencing, only to discover frustrating errors in the DNA. This episode dives deep into PCR accuracy and why it matters for everything from sequencing to cloning and long-read library prep. Laurynas breaks down the major contributors to PCR error, including the fidelity of DNA polymerase, primer design flaws, template impurities, and suboptimal cycling conditions. He then offers a range of solutions—like switching to high-fidelity enzymes, using ready-to-go master mixes, and optimizing magnesium ion concentrations. He also explains how reducing cycle numbers and fine-tuning annealing temperatures can minimize unwanted amplification and ensure more reliable data.Whether you're troubleshooting or proactively optimizing your workflow, this episode is packed with tips and tools to help you increase PCR accuracy, reduce costs, and save time. Episode notes contain links to enzyme comparisons, primer design tools, and cycling guides to help you PCR with precision.Helpful resource links mentioned in this episode:Thermo Scientific web tools for primer design and analysis, and moreThe PCR Learning Center with lots of helpful tips and informationLearn more about PCR reagents and enzymesBrowse and purchase PCR enzymes and master mixesAccess the PCR troubleshooting guideDownload the molecular biology handbook  Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

Cory grew up in Maine and after spending time as a sea kayak guide and a ski instructor, found his way to biology and laboratory research. Currently a Postdoctoral Researcher in the Haller Lab at MDI Biological Laboratory, Cory is interested in the cell biology of kidney vascularization and uses renal organoids and zebrafish to investigate how we may, one day, be able to rebuild the kidney and develop non-donor solutions to kidney transplantation.Cory was one of the 5 Minute Genius™ speakers at this past year's Maine Science Festival; you can see his talk on our YouTube channel.This conversation was recorded in May 2025. ~~~~~The Maine Science Podcast is a production of the Maine Discovery Museum. It is recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle. The Discover Maine theme was composed and performed by Nick Parker. To support our work: https://www.mainediscoverymuseum.org/donate. Find us online:Maine Discovery MuseumMaine Discovery Museum on social media: Facebook Instagram LinkedIn Bluesky Maine Science Festival on social media: Facebook Instagram LinkedInMaine Science Podcast on social media: Facebook Instagram © 2025 Maine Discovery Museum

In 2018, a peer-reviewed article published in Progress in Biophysics and Molecular Biology suggested the theory that octopuses could have extraterrestrial origins. As in, they're not regular Earthlings. The 33 scientists who authored the paper say, the octopus could have arrived on Earth, in some form, on board a celestial body – like an asteroid. Most of the scientific community disagreed. Experts said octopuses are alien-like, but there are clues to suggest they experienced a normal, Earth-bound evolution. However…they might hold clues about what alien behavior would look like. Today, we're joined by researcher Dominic Sivitilli, who tells us what studying octopus cognition can teach us about alien intelligence. Keep up with us on Instagram @theconspiracypod! Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of Speaking of Mol Bio, Dr. Cath Moore of the Australian Genome Research Facility (AGRF) discusses how molecular biology technologies are helping to shape Australia's scientific landscape—from clinical genomics and conservation to bioremediation and agriculture. With over 20 years of experience in both academia and industry, Dr. Moore reflects on the remarkable evolution of genomic tools, from Sanger sequencing to high-resolution spatial multiomics.She unpacks AGRF's mission to democratize access to emerging technologies and highlights its role as an early adopter of platforms that help scientists translate academic research into real-world impact. Topics include non-mass spec proteomics, mine site rehabilitation through soil microbiome analysis, and the role of systems biology in modern science.Dr. Moore also discusses the importance of community education and literacy around genomics, emphasizing how public understanding is key to the safe adoption of emerging technologies like synthetic biology. Finally, she shares career insights and advice for aspiring scientists: stay curious, stay broad, and don't be afraid to pivot when your work no longer brings joy. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

Looking for more information on this topic? Check out the Emergent Hypertension brick. If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/ from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.

In this Mol Bio Minutes episode, Laurynas Alijošius breaks down how to run fast PCR to save time and increase lab efficiency. He explains how to choose the right thermal cycler with fast ramp speeds, select low-volume and thin-walled PCR plastics, and use engineered DNA polymerases that offer rapid elongation and hot-start capability. Laurynas also covers practical tips for optimizing reaction components, shortening cycling protocols, and reducing waste. Whether you're aiming to finish your experiment before dinner or streamline your workflow long-term, this episode delivers everything you need to master the art of fast PCR.Helpful resource links mentioned in this episode:Molecular biology handbook – An extensive resource for all things molecular biologyApplied Biosystems thermal cyclers – Including those that support fast PCRPCR consumables – Four key attributes to considerPCR plastics selection tool – Find the right plastics for your instrument and fast PCRDNA polymerases – Four key characteristics to know and considerPCR setup optimization – Six critical things to optimize for optimal PCR resultsEnzymes and master mixes – Get the right reagents to drive your PCR reactionCycling optimization – Instrument considerations for PCR success Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

Lisa Markowitz currently teaches Introduction to Cultural Anthropology, People and their Food, Anthropology of Latin America, Globalizing Inequalities, Food Justice, and Contemporary Issues in Anthropology, at the University of Louisville. Markowitz's research has focused on inequities in regional and global agrifood systems and popular efforts to transform them. These linked themes have informed her writing and scholarly-civic engagement in Andean South America and the upper U.S. South. She has carried out ethnographic field research in Peru and Bolivia, exploring the situation of peasant farmers and ranchers and their use of communal or collective strategies to improve their production systems and economic bargaining power. This experience led to a long-term interest in Andean food and agriculture as well as an engagement with building equitable food systems in the United States Her work has also addressed the roles of Non-governmental organizations as change agents in South America and the United States. Her most recent project concerns the grocery industry. Michael Perlin: Dr. Michael Perlin teaches Biology 330 Genetics & Molecular Biology, Biol 410 Misuse of Biology in Film and Pop Culture, Biol 542/642 Gene Structure and Function, Biol 416 Biotechnology Methods, and Biol 575/675 Evolution of Genes and Genomes. As a biologist Dr. Michael Perlin investigates the evolution of host/pathogen interactions, primarily at the molecular genetics and biochemical levels. The research in Michael Perlin's lab focuses on the evolution of interactions between pathogens and the hosts on which they cause disease. At present, this work has two main areas of emphasis: fungal/plant interactions and population dynamics of bacteria resistant to antibiotics.

I'm thrilled to sit down with Dr. Lorna Rodriguez, a medical doctor with a PhD in biochemistry and a true double doc!

Cystic Fibrosis and obesity?  Until recently this has not been a topic of conversation for the CF community. The reason for obesity in the CF community is better health and longer lives, so the concern is now a reality.  University of Michigan CF doctor, Carey Lumeng is researching the issue.  As he says in this podcast, researchers have a lot to learn about the connection between better health in CF and obesity.  We also talk about The Bonnell Foundation fellowship program. A few years ago we started the program to encourage doctors to work in the specialty field of cystic fibrosis. Dr. Lumeng is one of the doctors who oversees this program.Dr. Lumeng is the Frederick G.L. Huetwell Professor for the Cure and Prevention of Birth Defects and Professor in Pediatrics and Molecular and Integrative Physiology. Dr. Lumeng is the Division Chief of Pediatric Pulmonology at the C.S. Mott Children's Hospital and Associate Director of the Michigan MSTP Program.He grew up in Indiana and graduated from Princeton University in Molecular Biology. He received his PhD in Human Genetics and MD from the University of Michigan and completed residency training in Pediatrics in the Boston Combined Pediatrics Residency Program at Boston Children's Hospital and Boston Medical Center. He then completed fellowship training in Pediatric Pulmonology at the University of Michigan and started as faculty in 2006.  He runs a research lab focused on the health effects of obesity and the links between metabolism and lung health. The laboratory participates in both basic science and translational research projects in adult and pediatric obesity. He is funded by the NIH and the CF Foundation for new projects studying the changing causes of diabetes in people with CF.To contact the CF pediatric department (the Bonnell girls are pictured on this page): https://www.mottchildren.org/conditions-treatments/cystic-fibrosis-pediatric?pk_vid=6ff46bd2d38fe04c1739891353f5b28b Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en

Richard Warren Beckwith is a highly accomplished attorney with a diverse and eclectic backgroundspanning law, molecular biology, and media. Currently serving as the City Attorney for Rock Springs,Wyoming, he brings a wealth of experience and expertise to his role. He is the Wyoming State Directorfor the Mutual UFO Network (MUFON) and a member of the MUFON International Board of Directors. Heis also the host of the Official MUFON Podcast. He has been investigating UFOs for more than fifty years,and professionally for nearly twenty.Beckwith earned a Bachelor of Science Degree in Molecular Biology from the University of Wyoming anda Juris Doctorate from the University of Wyoming College of Law. His legal career has included roles asPrincipal Partner in a prestigious local law firm, General Counsel to Dr. Steven Greer's Orion Project, andLegal Counsel to the MUFON Board of Directors. As a skilled litigator and negotiator, he has handled awide range of legal matters, including:• Criminal Defense• Construction Litigation• Complex Civil Litigation• Real estate Law• Administrative and agency law• Labor and employment law• Non-disclosure agreementsPrior to his legal career, Beckwith worked as a microbiologist studying the leaching of selenium in soil, asa lab technician in a molecular virology lab attempting to isolate a plant protein related to the humanimmune response, as a lab technician in a molecular genetics laboratory searching for the Ori of Serratia;and as a lab technician in an atmospheric microbiology laboratory studying atmospheric bacteriapopulations.His diverse background includes experience as a professional musician and broadcaster, serving as aProgram Director, Production Director, News Director, and Air Personality for numerous broadcastingorganizations.An active member of the legal community, Beckwith has held numerous leadership positions in theSweetwater County Bar Association and is a member of the Wyoming Bar Association and the AmericanBar Association.With his unique blend of legal expertise, scientific knowledge, and media experience, Richard WarrenBeckwith continues to make significant contributions to the UFO/UAP community and beyond.Become a supporter of this podcast: https://www.spreaker.com/podcast/night-dreams-talk-radio-with-gary-anderson--2788432/support.

Your cells are starving. Not for food—but for oxygen. In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Jason Sonners, world-renowned hyperbaric expert and regenerative medicine pioneer, to reveal how controlled oxygen under pressure is becoming one of the most powerful tools in anti-aging and performance science. You'll learn how hyperbaric oxygen therapy (HBOT) triggers stem cell activation, rewires your epigenome, boosts mitochondrial energy, and reverses biological aging—if you use it the right way. Jason shares breakthrough findings from his latest PhD research comparing low- and high-pressure chambers, with surprising results on inflammation, telomeres, cognitive performance, and recovery speed. This is next-gen longevity—measurable, stackable, and customizable. From sleep upgrades and HRV boosts to stacking HBOT with fasting, methylene blue, or red light, this episode dives into what it takes to oxygenate your biology at the deepest level. You'll Learn: • How hyperbaric oxygen therapy (HBOT) triggers stem cell regeneration and cellular repair • Why mild-pressure chambers may be more powerful than you think• What HBOT does to inflammation, brain fog, and biological aging markers • How to stack HBOT with fasting, red light, and methylene blue for amplified results • What Dr. Sonners' PhD research reveals about oxygen pressure and genetic expression • The truth about oxygen toxicity—and how to avoid the common mistakes • How elite performers use HBOT for brain optimization, recovery, and resilience ** Get 30% of yourr tickets to the Biohacking conference by going to https://biohackingconference.com/2025 and use code ‘OXYHEALTH' ** Thank you to our sponsors! -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Jason's Website – www.hbotusa.com • OxyHealth Website: https://www.oxyhealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:59 Intro • 03:14 New research on aging and oxygen • 05:39 Mild vs. hard-shell chambers • 13:05 HBOT for longevity and stem cells • 16:43 How to optimize your sessions • 22:35 Best therapies to stack with HBOT • 25:40 Oxygen delivery and safety • 26:43 Altitude and chamber effects • 30:01 Key benefits of hyperbaric therapy • 34:22 Supplement synergy and timing • 37:25 Pressure and oxygenation findings • 39:27 Medical vs. welding oxygen • 44:57 Safety myths and toxicity risks • 47:39 Future of biohacking with oxygen See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ep. 182 (Part 2 of 2) | Robert Lawrence Kuhn, producer of the popular PBS series Closer to Truth, which explores consciousness, the mystery of existence, and related topics with an open-minded approach, recently authored a remarkable article: “A Landscape of Consciousness,” in which he surveyed over 200 theories about what consciousness is. Robert tells how he inhabited each theory for a few days while writing it up, and discovered that unlike with other fields of knowledge, a study of consciousness produces more theories the more we know, rather than narrowing the field down. He emphasizes we need to be expansive with our universe of understanding of what consciousness is, and realize that how we engage with the Big Questions of life depends upon our particular theory of consciousness.Robert tells how the Big Questions, notably what is consciousness and why is there something rather than nothing, have called him all his life, leading him to create the Closer to Truth series, to explore these questions with the leading minds of our time. What Robert didn't know to begin with, but marvels about now, is how the passion for delving into the most fundamental, existential questions we face as humans unifies people around the world, from every demographic, providing a unique and wonderful point of integration. This is a fascinating, warm, engaging conversation that draws us ever farther into an exploration of the mysteries of life, where we glimpse what lies at the core of humanity. Recorded April 17th, 2025.“It's not that we have too many theories of consciousness, it's that we have one too few.”Topics & Time Stamps – Part 2The challenge of putting these theories into a digestible form (00:54)Understanding our personal theories of consciousness as extensions of our worldview (03:14)Our own theories often evolve from materialism to panpsychism to idealism (07:11)How the title Closer to Truth for the PBS/YouTube series came about (11:59)It's easier to entertain materialist or atheist theories in environments constructed by humans—exposed to the natural universe, you encounter awe, wonder, connection (14:04)The concept of awe and transcendence in art and how it reflects our nature of mind (16:16)What has exploring these theories of consciousness done to Robert? (17:59)The closer we look, the more we end up in bottomless mystery (23:36)How exploring the Big Questions unifies people—cutting across religion, race, culture (25:28) Acknowledging the limits of knowledge—epistemic humility—appreciating the mystery, and universality (29:54)The deeper your understanding goes, the richer your appreciation and awe (31:16)Resources & References – Part 2Robert Lawrence Kuhn, creator, producer, and host of the PBS series, Closer To TruthRobert Lawrence Kuhn, “A Landscape of Consciousness,”article in Progress in Biophysics & Molecular Biology, August 2024Paul Davies, quantum physicist, director of BEYOND: Center for Fundamental Concepts in Science, “The universe is about something.”

Thomas Lo, M.D., D.ABA, aka "Chef Dr. Lo," is a board-certified Anesthesiologist, Chef, CEO, and Entrepreneur. After graduating from Yale University with a degree in Molecular Biology, Dr. Chef Lo began his professional culinary career studying at the French Culinary Institute in New York. With a strong background in fundamental culinary techniques, Thomas interned at Veritas and Lupa Osteria and then joined the opening team of Virot restaurant at the Dylan Hotel in New York. Chef Dr. Lo is also the owner and culinary director of Spy C Cuisine restaurant in Forest Hills, New York. Spy C Cuisine has quickly gained critical accolades from the New York Times and received its first Michelin Bib Gourmand in 2020. With the understanding of the molecular physiology of taste, Chef Dr. Lo enjoys playing with the palate by synergistically combining flavor combinations and balancing the harmonies of sweet, salty, bitter, and sour. By contrasting various textures of his dishes, Chef Dr. Lo attempts to introduce the complexities and subtleties of food to you. As a Chef Physician, he is able to educate his customers, patients, and fellow colleagues on the medicinal aspects of haute cuisine. As a chef anesthesiologist, Chef Dr. Lo is known for his Sichuan Mind-Numbing Sauce, which must be properly prepared and used for dishes to provide the perfect balanced flavor profile. When given in the proper amount, harmony is achieved; but when too much is given, the flavors are overpowering. Although this would not be like a true overdose that Chef Dr. Lo sees in the operating room, the taste of the dish becomes acrimonious.

This episode teaches that innovation is born at the intersection of curiosity and persistence. Dr. Gudrun Stengel, co-founder and CEO of Alida Biosciences, reveals how her startup is transforming the landscape of RNA research through a novel technology called proximity barcoding. Dr. Stengel's story exemplifies the power of entrepreneurial spirit in driving scientific discovery, offering a glimpse into how one idea can reshape an entire field.At Alida Biosciences, Dr. Stengel and her team are pioneering new tools for detecting RNA modifications, a largely unexplored realm of epigenetics. Using their proximity barcoding platform, researchers can read multiple RNA modifications simultaneously, uncovering potential biomarkers and therapeutic targets for diseases like cancer, Alzheimer's, and diabetes. This technology bridges a critical gap in multiomics, allowing scientists to dive deeper into how epigenetic changes influence gene expression and cellular behavior.Beyond the lab, Dr. Stengel shares her experience as a first-time founder, balancing scientific rigor with startup life. From managing a team to fundraising, her journey underscores the importance of resilience, optimism, and maintaining a long-term vision. She also offers valuable advice for budding scientists, encouraging them to embrace challenges and remain persistent in the face of setbacks. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

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Today we are joined by a remarkable guest, Dr. Trenna Sutcliffe, a board-certified developmental-behavioral pediatrician and the founder of the Sutcliffe Clinic in the San Francisco Bay Area. Her educational history is impressive. She completed her undergraduate education in Molecular Biology and Medical Genetics followed by a masters degree in Biophysics at The University of Toronto. She obtained her Medical degree at McMaster University before her pediatric residency and training finished at the Hospital for Sick Children in Toronto. And oh by the way, she then did a year of pediatric Neurology residency and a Fellowship in Developmental Pediatrics. And finally, another Masters degree in Epidemiology at Stanford University. Thus, her educational path has allowed her to see the developmental landscape through a wider lens covering many disciplines. Dr. Sutcliffe started the first Developmental Pediatrics Clinic at Stanford and played the role of trailblazer throughout her career. With over 25 years of experience, Dr. Sutcliffe specializes in supporting children with autism, ADHD, and anxiety, offering a multidisciplinary approach to diagnosis and treatment. In this episode, she'll share her insights on the rising prevalence of these conditions, the importance of personalized care, and practical strategies for parents navigating developmental challenge. Fundamentally, Dr. Sutcliffe is a going to educate us on a better way to deliver whole person care to the developmentally challenged and beautiful children of this country. Two words encapsulate her work: empowering and thoughtful. Let's dive into this conversation with Dr. Sutcliffe to learn how we can help our children thrive! Dr. M

What happens when scientific curiosity meets life-changing opportunity? Nicole Mumbi shares her remarkable journey and provides a powerful answer to this question.Moving from Nairobi, Kenya to Boston in 2019, Nicole faced the challenge of cultural transition while nurturing her budding interest in science. Though initially experiencing culture shock and language barriers, her determination never wavered. A simple middle school experiment on atmospheric pressure had already planted the seed of scientific fascination that would shape her future path.When Nicole's high school guidance counselor suggested applying to the BioBuilder Apprenticeship Program, she seized the opportunity despite her fears and busy academic schedule. At Ginkgo Bioworks' Learning Lab, Nicole and her team developed "Break the Stigma" – an innovative at-home HIV detection project that engineered bacterial cells with CD4 receptors to detect the virus in blood samples. This first-hand laboratory experience transformed her understanding of science from textbook concepts to real-world applications.The technical skills Nicole gained – from PCR to scientific presentation – became the foundation for her subsequent internship at the prestigious Ragon Institute. Now thriving as a Biochemistry and Molecular Biology student at UMass Amherst, she gives back by tutoring other students in chemistry while contemplating whether her future lies in research, medicine, or a combination of both.Throughout her story, Nicole emphasizes the importance of pushing past imposter syndrome to take chances. "I remember having this imposter syndrome person talking to me saying, 'I don't think you have enough qualifications,'" she shares. "But I was grateful for my mom's encouragement to partake in opportunities without feeling like an outsider."Learn more about BioBuilder's programs for students, educators, and industry professionals here

Michael Hughes is a postdoctoral researcher at St. Jude's Children's Hospital who studies the overlooked role of water in living systems. His work builds on a growing body of research suggesting that water is not just a passive solvent, but a highly structured, information-rich medium. Hughes proposes that under normal biological conditions, water's ability to form liquid crystalline phases, hydration shells, and coherent domains allows it to act more like an information storage system than an inert backdrop to biochemistry. Drawing on ideas like EZ water, interfacial water dynamics, and liquid-liquid phase separation inside cells that span thinkers from Gilbert Ling to Gerald Pollack, Hughes argues that health emerges from the fine-tuned electrical and structural properties of intracellular water. When this water-protein-electrical system breaks down, disease can result. He outlines a new approach to the body that's rooted in biophysics, not just molecular biology, which he believes might offer novel ways to maintain health and slow aging by restoring the electromagnetic coherence of the body.MAKE HISTORY WITH US THIS SUMMER:https://demystifysci.com/demysticon-2025PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showPreprint of Michael's manuscript "Rethinking Cellular Organization: Phase Separation as a Unifying Principle in Molecular Biology" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5171413Dr. Thomas Seyfried podcast w/ DemystifyScihttps://www.youtube.com/watch?v=rxHkXP3G3y4"Live Streaming of a Single Cell's Life over a Local pH Monitoring Nanowire Waveguide" https://pubs.acs.org/doi/10.1021/acs.nanolett.2c02185Rudolf Steiner's Agriculture Course: https://www.youtube.com/watch?v=fwSa8Lpy9-A 00:00 Go! 00:09:54 – Water, Fields & the Electric Body 00:15:01 – Biochemistry's Unifying Principles 00:21:26 – Water, Glutamine & Metabolism 00:23:02 – Liquid-Liquid Phase Separation 00:25:34 – Hydration & Cellular Structure 00:28:08 – Amyloids in Health & Disease 00:33:52 – Environment Shapes Amyloids 00:39:37 – Osmosis, Metabolism & Flow 00:41:04 – Soil Over Seed: Health Revolution 00:42:24 – Evolving Scientific Paradigms 00:46:08 – Cell Theory & Liquid Separation 00:50:34 – Rethinking Genetic Primacy 00:56:12 – Biochemical Research Challenges 01:01:58 – Terrain Theory & Post-Pandemic Trust 01:13:16 – Technology, Ethics & Evolution 01:16:06 – Metabolism as Societal Metaphor 01:21:09 – Lifespan, Healthspan & Food Systems 01:23:25 – Terrain Theory & Neurodegenerative Disease 01:25:10 – pH, Buffers & Biochemical Balance 01:30:03 – Cellular Function & pH Dynamics 01:35:17 – Biochemical Cell Environment 01:39:06 – Intracellular Phase Separation 01:43:07 – Insulin, Gradients & Phase Transitions 01:45:12 – Water, Food & Environmental Impacts 01:48:14 – Personal Diet & Exercise Design 01:57:09 – Experimenting with Your Health 02:00:11 – Dyno comp! #electricuniverse #biochemistry, #structuredwater , #cellularhealth, #watermemory, #metabolism, #quantumhealth, #naturalmedicine, #integrativemedicine, #nutritionalscience, #epigenetics, #philosophypodcast, #sciencepodcast, #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

Sustainability in the lab isn't just a trend—it's a responsibility. In this quick but powerful Mol Bio Minutes episode, sustainability expert Sune Lund Sporring shares actionable tips to reduce energy use, manage lab waste, and transition to greener materials like Thermo Fisher's Sustain Series bio-based plastics.Discover the difference between bio-based and biodegradable, why second-generation feedstocks are a game-changer, and how to make low-impact changes without compromising performance. Learn how small shifts—like using aluminum beads instead of water in a bath or switching to carbon-reduced plastics—can significantly cut your lab's carbon footprint. And remember: if greener options aren't available, your demand can help shape the market.Helpful resource links mentioned in this episode:My Green Lab – Facts and resources about lab sustainabilityEnergy use of fume hoods – Energy use and savings ideas for fume hoodsGreener by Design – Thermo Fisher's approach to green solutionsLab Armor™ Beads – A sustainable option to replace water in water bathsInstrument trade up program – trade in your equipment to be green and give it a second lifeLab plastic waste – Stats about plastic waste in labsDoing something about it – Thermo Fisher's lower carbon plastics solutionSustain Series PCR plastics – Lower carbon footprint, without workflow interruptionReasons to believe – Fact sheet about Sustain Series PCR plastics Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

 Scientists are using the secrets of biology to unlock living well past current human life spans. Venki Ramakrishnan shared the 2009 Nobel Prize in Chemistry for uncovering the structure of the ribosome. A member of the National Academy of Sciences, Venki runs a research group at the MRC Laboratory of Molecular Biology in Cambridge, England. He joins host Krys Boyd to discuss the quest to live forever, if that's even ethical, and what it looks like to alter our physiology. His book is “Why We Die: The New Science of Aging and the Quest for Immortality.”  Learn about your ad choices: dovetail.prx.org/ad-choices

Dr. Hoffman continues his conversation with Dr. Garth Nicolson, Founder, President, Chief Scientific Officer, and Emeritus Research Professor of Molecular Pathology at the Institute for Molecular Medicine in Huntington Beach, California, and Research Advisor for Nutritional Therapeutics, makers of NTFactor.

Unlocking the Power of Mitochondria: Dr. Garth Nicolson, a leading expert in molecular pathology, explores the critical role of mitochondria in energy production and overall health. His groundbreaking research reveals how repairing and restoring cell membranes improves health by increasing energy, decreasing fatigue, and slowing the aging process. The discussion delves into Dr. Nicolson's findings, including his influential fluid mosaic model of cell membrane structure. The focus then shifts to the importance of maintaining mitochondrial membrane integrity to combat aging and various age-related clinical conditions. Dr. Nicolson explains the benefits of membrane lipid replacement therapy using NT Factor Lipids to restore mitochondrial function, address fatigue, support recovery from chemotherapy, aid in chronic illnesses like fibromyalgia and long COVID, and assist in conditions such as schizophrenia, autism, and EMF sensitivity. The episode highlights the broad therapeutic potential of NT Factor Lipids, emphasizing their role in enhancing energy levels, promoting healing, and improving overall cellular health.

Dr. Jessica Rose is an artist, musician, mathematician, professional surfer, biologist, science researcher & data analysis. Dr. Rose has a Post Doc in Biochemistry at Technion Institute of Technology, Post Doc in Molecular Biology at Hebrew University of Jerusalem, PhD in Computational Biology at Bar-Ilan University, Master's in Medicine (Immunology) at Memorial University of Newfoundland, and BSc in Applied Mathematics at Memorial University of Newfoundland.DR. JESSICA ROSE:Twitter: https://twitter.com/JesslovesMJKSubStack: https://jessicar.substack.com/YouTube: https://www.youtube.com/channel/UC0EhWf2Vswdg7DwKKKZ34ngTHE RIPPLE EFFECT PODCAST:WEBSITE: http://TheRippleEffectPodcast.comWebsite Host & Video Distributor: https://ContentSafe.co/SUPPORT:PATREON: https://www.patreon.com/TheRippleEffectPodcastPayPal: https://www.PayPal.com/paypalme/RvTheory6VENMO: https://venmo.com/code?user_id=3625073915201071418&created=1663262894MERCH Store: http://www.TheRippleEffectPodcastMerch.comMUSIC: https://music.apple.com/us/album/the-ripple-effect-ep/1057436436SPONSORS:OPUS A.I. Clip Creator: https://www.opus.pro/?via=RickyVarandasUniversity of Reason-Autonomy: https://www.universityofreason.com/a/2147825829/ouiRXFoL WATCH:RUMBLE: https://rumble.com/c/therippleeffectpodcastBANNED.VIDEO: https://banned.video/channel/the-ripple-effect-podcastOFFICIAL YOUTUBE: https://www.youtube.com/@TheRippleEffectPodcastOFFICIALYOUTUBE CLIPS CHANNEL: https://www.youtube.com/@RickyVarandasTikTok: https://www.tiktok.com/@ricky.varandasLISTEN:SPOTIFY: https://open.spotify.com/show/4lpFhHI6CqdZKW0QDyOicJiTUNES: http://apple.co/1xjWmlFPodOmatic: https://www.podomatic.com/podcasts/rvtheory6CONNECT:TeleGram: https://t.me/TREpodcastX: https://x.com/RvTheory6IG: https://www.instagram.com/rvtheory6/ FB: https://www.facebook.com/TheRippleEffectPodcast/THE UNION OF THE UNWANTED: https://linktr.ee/TheUnionOfTheUnwanted

Today we discuss: Cerebrospinal Fluid (CSF) leaksAgenda:  1. Dr. Cardenas: Tell us your story!  2.     So, what is a CSF leak? a.     What is leaking? From where? Why do leaks happen? b.     Common symptoms? Uncommon symptoms? c.     Why don't more people know about this?  3.     Okay, so let's go back to basic anatomy & let's go from general to specific- talk to us about: a.     connective tissueb.     vasculaturec.     central nervous system flow: CSF, lymph, bloodd.     Relationship with bones like CCI, Eagle's, others?e.     Relationship with the vasculature/ flow in the rest of the body like pelvic venous congestion 4.     How do we evaluate for this?b.     Imagingc.     Blood patches d.     Embolization  5.     How do we TREAT this? a.     Immediate: Blood patches/ embolization/ pressure adjustments (meds, etc) b.     Counter facial strain. What is it & how does it help? Role for other physical tx like PT/ chiro?Bio: Dr Brianna Cardenas is a Physician Assistant, a certified athletic trainer and the founder of Healed and Empowered, an organization that specializes in optimizing health among those living with chronic illness. She has recently joined the team at NeuroVeda Health where she brings 13 years of healthcare experience. She is also a patient living with Ehlers-Danlos Syndrome, an “invisible” condition that can be hard to diagnose and often discounted by healthcare providers as a result. Brianna's lived experience as a patient informs her work as a healthcare provider to others.Bio: Dr. Maxwell is a Board Certified Pediatric Cardiologist and Pediatrician. He received his medical degree from Johns Hopkins Medical School and a Residency in Pediatrics at The University of California at San Francisco followed by clinical and research fellowships in Pediatric Cardiology at Lucile Salter Packard and Stanford Hospitals and Children's Hospital of Philadelphia. His research interests include study of endothelial control of vasomotor tone, nitric oxide, sports cardiology, dysautonomia, hypermobility syndromes, & mast cell activation syndrome and their relationships to environmental toxins. For his research he received an American Heart Association Award for Research in Molecular Biology and was an American College of Cardiology Young Investigator Award finalist. He has published many articles and book chapters on these subjects. For his clinical work, he has been voted by his peers as a Top Doctor in Northern California annually since 2017.Resources/ Links/ Articles: ·       https://www.eds.clinic/articles/spiky-leaky-syndrome·       https://www.medicalandresearch.com/current_issue/1962

Episode 128 In part 22 of our Sinai and Synapses interview series, we are talking with Dr Ciara Reyes-Ton. She is a biologist, science writer, and editor who is passionate about science communication to faith communities. She has a Ph.D. in Cell & Molecular Biology from the University of Michigan. She has served as Managing Editor for the American Scientific Affiliation's God & Nature Magazine. She is currently the Digital Content Editor for BioLogos and an Adjunct Professor at Lipscomb University. She also recently helped found the Science Communicators of Faith (SCF), a group dedicated to providing a supportive, collaborative, and Christ-centered community for people of all backgrounds and skill levels to grow in the craft of science communication. She is also the author of “Look Closely,” a science and faith devotional that explores the life of Christ by bringing scripture in conversation with science, from water-walking lizards to dividing cells and resurrecting corals. Outside science, she has a heart for worship and is a proud mom. https://www.mountcarmell.com/   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Being a scientist is a way of looking at the world, and asking the question 'why' without your own pre-conceived notions. I've learned that it's also a great way of doing business. -Julia Wrin Piper How do you go from scientist to CEO? Meet Julia Wrin Piper. She's got degrees in Molecular Biology, Neuroscience, and Evolutionary Biology from UC/Berkeley, the Salk Institute for Biological Sciences, and Harvard University, and she's using years of scientific training to forward the mission of Clover, a Boston-area fast casual chain specializing in local, seasonal sandwiches and bowls. www.cloverfoodlab.com. Clover's mission is to significantly reduce carbon emissions through the creation of delicious, sustainably-sourced, plant-based fast food. Says Julia: “We take beautiful food that people are familiar with, and reinvent it with 100% locally sourced vegetarian ingredients. We want you to love your veggies so much, you dream about them.” Clover's Cambridge-based culinary experts work directly with farmers in the region. Born and raised in California's Bay Area, Julia's mom is a virologist who was at the forefront of HIV research and continued to offer her scientific expertise during the COVID-19 pandemic. Her father was a stay-at-home dad for many years before taking a job as an educator. Now a mother herself, Julia deeply appreciates the home she grew up in: “It was like no other. My mom was my role model, and having my father at home gave us a wonderful and very different perspective. What does the future look like for Clover under Julia's leadership? Chances are, there will be a Clover near you as the company eyes expansion beyond Massachusetts. “Being a scientist is a way of looking at the world, asking the question 'why' without your own pre-conceived notions. I've learned that it's also a great way of doing business. For 23 minutes with a woman who makes science yummy and fun, just hit that download button. #scientist #veggies #climatechange #STEM #local #carbonfootprint

What is the state of the intelligent design movement today? How is it faring in the scientific realm, the church, and in the public? How has the strategy of the ID movement shifted, and what has it learned over the past 20 years? Our guest today is Biola University Biology professor Doug Axe.Douglas Axe is the Maxwell Professor of Molecular Biology at Biola University, the founding Director of Biologic Institute, the founding Editor of BIO-Complexity, and the author of Undeniable: How Biology Confirms Our Intuition That Life Is Designed. After completing his PhD at Caltech, he held postdoctoral and research scientist positions at the University of Cambridge and the Cambridge Medical Research Council Centre. His research, which examines the functional and structural constraints on the evolution of proteins and protein systems, has been featured in many scientific journals, including the Journal of Molecular Biology, the Proceedings of the National Academy of Sciences, BIO-Complexity, and Nature, and in such books as Signature in the Cell and Darwin's Doubt by Stephen Meyer and Life's Solution by Simon Conway Morris.==========Think Biblically: Conversations on Faith and Culture is a podcast from Talbot School of Theology at Biola University, which offers degrees both online and on campus in Southern California. Find all episodes of Think Biblically at: https://www.biola.edu/think-biblically. Watch video episodes at: https://bit.ly/think-biblically-video. To submit comments, ask questions, or make suggestions on issues you'd like us to cover or guests you'd like us to have on the podcast, email us at thinkbiblically@biola.edu.

Are Vaccines Good For Us? Marschall S. Runge, M.D., Ph.D., was born in Austin, Texas, and graduated from Vanderbilt University with a BA in General Biology and a PhD in Molecular Biology. He received his medical degree from the Johns Hopkins School of Medicine and trained in internal medicine at Johns Hopkins Hospital. He was a cardiology fellow and junior faculty member at Massachusetts General Hospital. Dr. Runge's next position was at Emory University, where he directed the Cardiology Fellowship Training Program. He then moved to the University of Texas Medical Branch in Galveston, where he was Chief of Cardiology and Director of the Sealy Center for Molecular Cardiology. He joined the University of North Carolina (UNC) from 2000 – 2014, where he served as Charles Addison and Elizabeth Ann Sanders Distinguished Professor of Medicine, Chair of the Department of Medicine, President of UNC Physicians and Vice Dean for Clinical Affairs. Dr. Runge visits with Mark Alyn.Become a supporter of this podcast: https://www.spreaker.com/podcast/late-night-health-radio--2804369/support.

Are Vaccines Good For Us? Marschall S. Runge, M.D., Ph.D., was born in Austin, Texas, and graduated from Vanderbilt University with a BA in General Biology and a PhD in Molecular Biology. He received his medical degree from the Johns Hopkins School of Medicine and trained in internal medicine at Johns Hopkins Hospital. He was a cardiology fellow and junior faculty member at Massachusetts General Hospital. Dr. Runge's next position was at Emory University, where he directed the Cardiology Fellowship Training Program. He then moved to the University of Texas Medical Branch in Galveston, where he was Chief of Cardiology and Director of the Sealy Center for Molecular Cardiology. He joined the University of North Carolina (UNC) from 2000 – 2014, where he served as Charles Addison and Elizabeth Ann Sanders Distinguished Professor of Medicine, Chair of the Department of Medicine, President of UNC Physicians and Vice Dean for Clinical Affairs. Dr. Runge visits with Mark Alyn.Become a supporter of this podcast: https://www.spreaker.com/podcast/late-night-health-radio--2804369/support.

With Congress approving a plan to slash $880 billion from the federal budget, all eyes are turning to Medicaid as the most likely source of cuts. I asked Former North Carolina Health Secretary Kody Kinsley, KFF's Larry Levitt and California Health Care Foundation's Katie Heidorn to join me to discuss the likely shape and impact of proposed cuts, and take questions from UC Berkeley students. Kody called it a “self-licking ice cream cone”—cuts that destabilize the government, leading to further cuts. Larry warned of formula battles that will soon erupt. Katie laid out the devastating effects on state budgets.We've also released this episode as a full video episode on YouTube. Subscribe to The Other 80 YouTube channel for video extras, video episodes and viral healthcare policy content. Click here to watch this episode in full. Watch the full VIDEO version of this episode: https://www.youtube.com/watch?v=X110GShMTtE&t=52sRelevant LinksKFF: The Public's View on Potential Changes to MedicaidKFF: Impact of Medicaid Per Capita Cap Kody Kinsley testimony to Congress on MedicaidPre-election episode with Larry LevittKFF: Can Republicans cut $880 Billion without Slashing Medicaid?CBPP: Impact of Medicaid CutsCHCF: Defending Medi-Cal in 2025About Our GuestsKatie Heidorn is the director of state health policy at CHCF, where she leverages the foundation's data, expertise, and partnerships to help California's state government make informed decisions about health care. Katie is based in CHCF's Sacramento office.Katie has nearly two decades of experience working in health policy, government, and nonprofits and is a skilled leader, facilitator, and communicator. She comes to CHCF after more than two years as executive director for the Insure the Uninsured Project (ITUP). Before that, Katie was the government affairs advocate for Health Net and the development director and policy lead at the nonprofit California Coverage and Health Initiatives. Katie spent a decade in California state government, including as a deputy secretary for the California Health and Human Services Agency and principal consultant in the Senate Appropriations Committee. She is also an alumna of the California Senate Fellows Program.Katie received her master's degree in Public Administration from the University of Southern California and bachelor's degree in Biochemistry and Molecular Biology and Comparative Literature from the University of California, Davis.Source: https://www.chcf.org/person/katie-heidorn/Kody...

Dr. Eric Kmiec is Director of the Gene Editing Institute of the Helen F. Graham Cancer and Research Institute at Christiana Care Health System. He also holds faculty appointments at the University of Delaware and the Wistar Institute. Eric and his colleagues are working to develop new ways to treat cancer by destroying the genes that cause cancer cells to be resistant to typical therapies like chemotherapy, radiation, or immunotherapy. Throughout his life, Eric has enjoyed sports. He particularly likes playing baseball and hockey, and he still plays baseball competitively in a league in Philadelphia. Eric also spends much of his time doing landscaping and yard work. He Received his B.A. in Microbiology from Rutgers University, his M.S. in Cell Biology and Biochemistry from Southern Illinois University, and his Ph.D. in Molecular Biology and Biochemistry from the University of Florida School of Medicine. He conducted postdoctoral research at the University of Rochester before joining the faculty at the University of California, Davis in 1987. Since then, he has served on the faculty of Thomas Jefferson University, the University of Delaware, and Delaware State University. In addition, Eric founded, consulted for, and served as Vice President of Kimeragen, Inc., he was Chief Scientific Advisor for the Genomics Division of Tapestry Pharmaceuticals, was an Eminent Scholar and Director of the Marshall University Institute for Interdisciplinary Research, and also served as Co-Founder, Chief Scientific Officer, and a Board Member of OrphageniX. Eric has received numerous awards and honors over the course of his career, including receipt of the 2012 Proudford Foundation Unsung Hero Award in Sickle Cell Disease, designation as an Honorary Commander of the 436th Air Wing at Dover Air Force Base in 2013 and 2014, and also induction into the Southern Illinois University, Edwardsville Alumni Hall of Fame in 2012. Further, Eric and the team at the Gene Editing Institute were recently awarded the inaugural Life Sciences and Bio Innovation Award from the Philadelphia-Israeli Chamber of Commerce. In our interview, Eric shared his experiences in life and science.

In this episode of Absolute Gene-ius, Dr. C. Dustin Rubinstein takes us inside the world of advanced genome editing, where cutting-edge tools like CRISPR and digital PCR are helping shape the future of biomedical research.As the Director of the Advanced Genome Editing Laboratory at the University of Wisconsin-Madison, Dr. Rubinstein shares how his lab develops genetically engineered pig models to study diseases like neurofibromatosis and cancer, providing researchers with more clinically relevant models than traditional small animals. He explains how digital PCR plays a crucial role in confirming genome edits with absolute precision, eliminating the ambiguity that often comes with qPCR and sequencing alone. The discussion dives into the advantages of dPCR for copy number variation analysis and gene editing confirmation, emphasizing the importance of multiple complementary technologies in modern molecular biology.Beyond the science, Dr. Rubinstein reflects on his career path, the value of mentors, and the unpredictable nature of scientific discovery. He also joins in on some lighthearted lab humor and shares his most embarrassing (and proudest) moments in research. Tune in for an insightful and entertaining look at the intersection of gene editing, career evolution, and the future of molecular biology.Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

Glucose is the main source of energy for all forms of life, but it isn't usually stored as individual C6H12O6 molecules. Animals use glycogen to do that job. Glycogen is a large branched polymer of glucose molecules, linked together by α-1,4 and α-1,6 glycosidic bonds. The liver and muscles break down the stored glycogen whenever the body needs an extra boost of glucose. Glycogen storage diseases are genetic defects in glycogen metabolism resulting in accumulation of glycogen. What happens when macromolecules accumulate in cells? Cell damage and dysfunction. Because the liver and muscles are the two main organs that use glycogen, they are also the two most affected by glycogen storage diseases. In the liver, glycogen accumulation leads to hypoglycemia since the glycogen can't be broken down to glucose. Damage to the liver from extra glycogen can also lead to liver failure or even liver cancers. In the muscles, glycogen accumulation causes weakness, exercise intolerance, and potentially heart failure. There are at least 12 distinct glycogen storage diseases, but we'll cover only the 4 most common ones. After listening to this Audio Brick, you should be able to: Identify the most common glycogen storage diseases: von Gierke disease (type 1), Pompe disease (type 2), Cori disease (type 3), and McArdle disease (type 5). Identify the enzymes deficient in each of the most common glycogen storage diseases. Describe the clinical manifestations of each of the most common glycogen storage diseases. Describe management for each of the most common glycogen storage diseases. You can also check out the original brick from our Cellular and Molecular Biology collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology. *** If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/ from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.

In this episode, Adam Coster, CEO of Butterscotch Shenanigans, shares his unique journey of joining and growing the indie studio with his brothers Sam and Seth. Adam discusses their beginnings in 2012, the steep challenges they faced, and how a personal family crisis redefined their mission to bring joy through games.  He then shares insights into their different projects, including the highly anticipated sequel Crashlands 2, set for release in April. Balancing roles at the studio, the evolving game industry, and the impact of subscription services, Adam offers a candid look at the realities of indie game development. He also provides useful, actionable advice for aspiring game developers and discusses the potential and limitations of incorporating AI into game dev. Join us as we explore the fascinating intersection of science, family, and grassroots game development to share joy. Bio: Adam Coster's love for science carried him through a PhD in Cellular & Molecular Biology. Turns out it wasn't science he was into, but solving hard problems in general. Building a company from scratch in the highly-competitive and rapidly-changing games industry certainly fit that bill, and so Adam joined the team immediately after defending his dissertation. Adam creates all of the web technology that powers Butterscotch Shenanigan's games and studio, crunches numbers to figure out how the industry works, leads our business development efforts, and makes sure that the team has what it needs to make great games. Show Links: * Crashlands 2 - trailer * Crashlands 2 - Steam * Global Game Jam - website * PopCon Indy - website * GameMaker game engine - website * Battle Chef Brigade Deluxe - Steam * Butterscotch Shenanigans - podcast * Scientists Warn Trump's NIH Cuts Will Drop ‘Atom Bomb' On Health Research - HuffPost * The Creator of ‘NBA Jam' Admits That The Pistons Are A Cheat - SBNation * What Is ‘Balatro' And Why Is Everyone Addicted To It? - Forbes Connect With Links: * Adam Coster - website * Adam Coster - LinkedIn * Adam Coster - Bluesky * Butterscotch Shenanigans - website * Butterscotch Shenanigans - games * Butterscotch Shenanigans - YouTube Game Dev Advice Links:  * YouTube Podcasts - check out this episode with a guarantee of 100% more video * Patreon - career coaching through the Gain Wisdom membership * Game Dev Advice hotline: (224) 484-7733 * website - show notes, links, stuff * info@gamedevadvice.com - reach out! * Subscribe and go to the website for full show notes with links Learn more about your ad choices. Visit podcastchoices.com/adchoices

Max Pearson presents a collection of the week's Witness History interviews from the BBC World Service.We hear about the moment Dr Max Perutz discovered the haemoglobin structure.Our expert is Professor Sir Alan Fersht, who is a chemist at the Medical Research Council Laboratory of Molecular Biology and knew Dr Perutz personally.We also hear about 22 Inuit children from Greenland's indigenous population who were sent to Denmark as part of a social experiment in 1951.Also, when mixed-raced children from the then Belgian Congo known as ‘métis', were forcibly taken from their homes in 1953.When an eruption of violence in Assam led to an estimated 3,000 being killed in the Nellie massacre of 1983.Finally, the devastating impact of the 2010 tsunami in Chile and a woman who survived it.This programme contains outdated language which some people might find offensive.Contributors: Lectures and programmes from the BBC archive Professor Sir Alan Fersht - chemist at the Medical Research Council Laboratory of Molecular Biology. Helen Thiesen - a child in Denmark's Inuit children social experiment. Marie-José Loshi - one of the mixed-race ‘métis' who was forcibly removed from her home in the then Belgian Congo. Bedabrata Lahkar - a journalist for the Assam Tribune newspaper at the time of the Nellie massacre. Alison Campbell - a survivor of Chile's 2010 tsunami.(Photo: Dr Max Perutz and Dr Paul Kedrew. Credit: Hulton Deutsch/Contributor via Getty Images)

Looking for more information on this topic? Check out the Acid-Base Disorders: Putting it all Together brick. If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Twitter: https://twitter.com/mesage_hub Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including over 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.

Looking for more information on this topic? Check out the Adrenal Insufficiency brick. If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/ from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.

In this episode, we delve into the complex topic of vaccine safety and DNA contamination with Dr. Jessica Rose, an independent researcher with a BSc in Applied Mathematics, an MSc in Immunology, a Ph.D. in Computational Biology, and two postdoctoral fellowships in Molecular Biology and Biochemistry.  Since the start of the COVID-19 vaccine rollout, Dr. Rose has been meticulously analyzing VAERS data on adverse reactions. Her mission? To uncover the truth behind past and present health policies through rigorous, data-driven research…  Hit play to learn about: How Dr. Rose's understanding of mathematics and science came into conflict during the COVID narrative. The purpose of pharmacovigilance databases. The many “scams” that took place throughout the pandemic.  What happened when Dr. Rose compared the 2019 influenza vaccine-related injuries with those of Coronavirus. What will it take to get to the bottom of the inaccuracies of public health data? How do incorrect reports impact the welfare of our society? Join the conversation now to see for yourself! You can follow along with Dr. Rose and her ongoing work on Substack and X. Boost Your Brainpower with 15% OFF!  Fuel your mind with BrainSupreme Supplements and unlock your full potential. Get 15% OFF your order now using this exclusive link: brainsupreme.co/discount/findinggenius Hurry—your brain deserves the best! Episode also available on Apple Podcasts: http://apple.co/30PvU9C

Colleen Cutcliffe explores the microbiome's role during menopause, focusing on the estrobolome and gut bacteria's interaction with estrogen. She emphasizes the importance of gut health, particularly Acromantia, and discusses the negative impacts of birth control pills and antibiotics. Along with Dr. Mindy, they highlight essential microbes, dietary changes, and probiotics for wellness, and examine the long-term effects of weight loss drugs on the microbiome. Lastly, they stress measuring health through energy levels and the four pillars of well-being: nutrition, exercise, mental health, and the microbiome. To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep271 Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern's Children's Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. Check out our fasting membership at resetacademy.drmindypelz.com. Please note our medical disclaimer.