Clinical Gastroenterology and Hepatology Audio Summaries

Optimizing Outcomes of Single-operator Cholangioscopy-guided Biopsies: Results of a Randomized Trial. Supplementary Anal Imaging by Magnetic Resonance Enterography in Patients With Crohn's Disease Not Suspected of Having Perianal Fistulas. Efficacy of Epicutaneous Immunotherapy in Children With Milk-Induced Eosinophilic Esophagitis. Outcomes of Long-term Treatment of Chronic HBV Infection With Entecavir or Other Agents From a Randomized Trial in 24 Countries. Risk Of Gastrointestinal Bleeding Increases With Combinations Of Antithrombotic Agents And Patient Age.

Prevalence and Incidence of Intestinal Metaplasia and Dysplasia of Gastric Cardia in Barrett's Esophagus After Endoscopic Therapy. Effects of Vedolizumab in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Disease. Tofacitinib Treatment Is Associated With Modest and Reversible Increases in Serum Lipids in Patients With Ulcerative Colitis. Development and Validation of Hepamet Fibrosis Scoring System A Simple, Noninvasive Test to Identify Patients With Nonalcoholic Fatty Liver Disease With Advanced Fibrosis.

Efficacy of Pelvic Floor Muscle Training and Biofeedback vs Attention-control Treatment in Adults With Fecal Incontinence. Metachronous Neoplasias Arise in a Higher Proportion of Colon Segments From Which Large Polyps Were Previously Removed, and Can be Used to Estimate Incomplete Resection of 10-20 mm Colorectal Polyps. Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis. Association between Renal Function Pattern and Mortality in Patients with Cirrhosis.

Clinical and Molecular Features of Post-Colonoscopy Colorectal Cancers. Incidence of Immune-mediated Inflammatory Diseases Among Patients With Inflammatory Bowel Diseases in Denmark. Increased Risk of Death in First Year After Liver Transplantation Among Patients With Nonalcoholic Steatohepatitis vs Liver Disease of Other Etiologies. Daily Aspirin Use Associated With Reduced Risk for Fibrosis Progression in Patients With Nonalcoholic Fatty Liver Disease.

Rebleeding and Mortality After Lower Gastrointestinal Bleeding in Patients Taking Antiplatelets or Anticoagulants. Time to Colonoscopy and Risk of Colorectal Cancer in Patients With Positive Results From Fecal Immunochemical Tests. Efficacy of Live Attenuated Herpes Zoster Vaccine in Patients With Inflammatory Bowel Diseases. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study. Barriers and Facilitators to Mediterranean Diet Adoption by Patients With Nonalcoholic Fatty Liver Disease in Northern Europe.

Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis. Safety of Tofacitinib for Treatment of Ulcerative Colitis, Based on 4.4 Years of Data From Global Clinical Trials. Effects of Alcohol. Consumption and Metabolic Syndrome on Mortality in Patients With Nonalcoholic and Alcohol-Related Fatty Liver Disease. Preoperative Endoscopic Retrograde Cholangiopancreatography Is Not Associated With Increased Pancreatic Cancer Mortality. Association Between Endoscopist Personality and Rate of Adenoma Detection.

Accuracy of Noninvasive Scoring Systems in Assessing Risk of Death and Liver-Related Endpoints in Patients With Nonalcoholic Fatty Liver Disease. Most Patients With Gastroesophageal Reflux Disease Who Failed Proton Pump Inhibitor Therapy Have Functional Esophageal Disorders. Numbers and Features of Patients With a Diagnosis of Celiac Disease Without Duodenal Biopsy, Based on a National Survey. Clinical and Molecular Factors Associated With Histologic Response to Topical Steroids in Patients With Eosinophilic Esophagitis.

New data shed little light on if screening individuals at high-risk for pancreatic cancer is effective and cost-effective in the long term. Tofacitinib-induction therapy reduces symptoms within 3 days for patients with UC. Vedolizumab is effective for adult UC patients who are anti-tumor necrosis factor naive. ESD is safer and more effective than esophagectomy for early-stage esophageal squamous cell carcinoma. New findings show that endoscopic ultrasound accurately distinguishes celiac lymph nodes and celiac ganglia.

Progression of Barrett's Esophagus to Malignancy. Low-Dose Aspirin and Gastrointestinal Bleeding. Functional Nausea and Vomiting Disorders in Adults. Cost Effectiveness of Universal Screening for Hepatitis C Virus.

Safety and Efficacy of Budesonide Oral Suspension Maintenance Therapy in Patients With Eosinophilic Esophagitis. Safety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients. Acceptability, Accuracy, and Safety of Disposable Transnasal Capsule Endoscopy for Barrett's Esophagus Screening. Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe Panometry. Nonalcoholic Steatohepatitis is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates.

Previous Use of Antithrombotic Agents Reduces Mortality in Patients With High-risk Upper Gastrointestinal Bleeding. The Association Between Mutations in BRAF and Colorectal Cancer-Specific Survival Depends on Microsatellite Status and Tumor Stage. Patient-Reported Outcomes and Endoscopic Appearance of Ulcerative Colitis: A Systematic Review and Meta-Analysis.

Some medications for IBD increase risk for herpes zoster. Nationwide study in Korea shows increase in risk of herpes zoster in patients with IBD, especially for those with ulcerative colitis. New study shows long-term benefits of achieving maintained virologic response in patients with HBV, even after development of decompensated cirrhosis. BMI is a significant predictor in discrepancy when assessing fibrosis in NAFLD with MRE vs. TE. New study shows that restarting DOACs within 30 days doesn't significantly increase risk of recurrent GI bleeding or reduce risk of thromboembolism.

New study further suggests an association between IBD disease activity and cardiovascular risk. Clinicians should consider screening for latent tuberculosis prior to the initiation of corticosteroids for IBD. Diet and gut microbiota play an important role in CRC development, with low-inflammatory diets showing benefits. Granulocyte colony stimulating factor with or without N-acetyl cysteine may be a safe and effective treatment for severe alcoholic hepatitis.

Endoscopist-related factors, rather than biology, are more likely to account for interval cancers in the proximal colon. New data suggest that Crohn's patients have greater risk of high-risk HPV infection and thus may benefit from anal cancer screening. New study on the factors associated with response to placebo in IBD patients has implications for clinical trial design. Research finds an association between the grade of acute on chronic liver failure and response to terlipressin and albumin in hepatorenal syndrome.

New study of registry data adds important data to the temporal trends of surgical risk in pediatric Crohn's. Pancreatic lesions with a greater growth rate have increased odds of exhibiting worrisome features. The learning curve for POEM is longer in managing complex cases and avoiding risks than the learning curve for achieving technical proficiency. No histologic benefit in modest alcohol use in NAFLD patients.

Two new clinical trials show differences in the comparative diagnostic yield of EUS-guided FNA and FNB for pancreatic solid masses. Significantly variability exists in the burden of hospitalization across patients with chronic GI and liver diseases. New scoring system helps identify patients at risk for esophageal adenocarcinoma. Endoscopic balloon dilation plays a therapeutic role in treating Crohn's patients.

Meta-analysis looks at age, gender, smoking, and other risks associated with Barrett's esophagus. Cytopathologists have suboptimal interobserver agreement for EUS-FNA for diagnosis and staging of pancreatic cancer. New research sheds light on the association between mucosal and transmural healing in Crohn's patients. IBS and chronic fatigue can persist after the Giardia infection.

New meta-analysis shows that celiac disease is a global problem. Uncomplicated diverticular disease does not cause chronic GI symptoms. Patients with downstaging HCC by liver transplantation have excellent outcomes. Observational study shows that patients with anal and/or perianal Crohn's disease are at higher risk for anal and rectal cancer.

New systematic review looks at patient-reported outcome measures for IBD. New research highlights the importance of standardizing measures for clinical trials of ulcerative colitis. Identification of new biomarkers to guide vedolizumab use is necessary for treatment of IBD. Two articles by the same research group review topical issues in the management of IBD.

New data reinforce the perils of opiate use in IBD patients. Researchers find that non-CDI enteric infections are uncommon triggers of flares in IBD patients. Pioglitazone is effective for treating NASH in patients with or without diabetes. Hypothetical biomarker test with substantially better performance than FIT would be more cost-effective than FIT if its cost doesn't exceed $57.

New data suggest that urgent endoscopy within 6 hours may reduce mortality in selected high-risk patients with non-variceal upper GI bleeding. New decision-analytic model compares the effectiveness and cost-effectiveness of endoscopic therapy versus esophagectomy for T1a and T1b esophageal adenocarcinoma Diaphragmatic breathing reduces belching and PPI refractory gastroesophageal symptoms. Biliary sphincter of Oddidysfunction and suspected choledocholithias benefits from adoption of standardized practice algorithms for management of intermediate-risk patients to minimize unnecessary invasive testing.

Gluten-free diet may not be all that safe because of an increase in the accumulation of heavy metals. New study identifies optimal histologic cutoff for treatment of EoE. Researchers examine the benefits and risks of biologic treatment withdrawal in patients with Crohn's. New data shed light on the efficacy and limitations of budesonide as a second-line treatment for patients with autoimmune hepatitis.

New data indicate the recommendation to consider early TIPS in patients at high risk would not apply to the subgroups with Child-Pugh B cirrhosis. New study shows that PREMM is a tool that community practitioners can use to help diagnose Lynch Syndrome. Vaccination of infants against HiB and tetanus toxin is not affected by in utero exposure to biologic therapy for IBD. New High-Value Care Series article examines the use of different modalities for diagnosing liver fibrosis and cirrhosis.