Podcasts about Incidence

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Atrial Fibrillation/Flutter in Transthyretin Cardiac Amyloidosis: Prevalence, Incidence, Clinical Predictors, and Effect of Tafamidis.

Dr. Jerry Moore is an archaeologist, writer, editor, and professor of Emeritus in anthropology at California State University Dominguez Hills in Carson, CA. Moore has conducted archaeological research in Peru, Mexico, and southern California. Moore's principal expertise is on the prehistoric architecture and cultural landscapes in the Andes. He has written the books, "Architecture and Power in the Prehispanic Andes: The Archaeology of Public Buildings" (1996 Cambridge University Press), "Cultural Landscapes in the Prehispanic Andes: Archaeologies of Place" (2005 University Press of Florida), "The Prehistory of Home" (2012, University of California Press, recognized with the 2014 Society for American Archaeology Book Award), "A Prehistory of South America: Ancient Cultural Diversity on the Least-Known Continent" (2014, University Press of Colorado), and "Incidence of Travel: Recent Journeys in Ancient South America" (2017, University Press of Colorado). He is currently working on a new book, "Ancient Andean Houses: Making-Inhabiting-Studying." Moore is the co-editor with Donald Laylander of "The Prehistory of Baja California: Advances in the Archaeology of the Forgotten Peninsula" (2006 University Press of Florida) which was chosen as a 2007 Choice Distinguished Book. Also, Moore has written one of the leading textbooks on anthropological theory, "Visions of Culture: An Introduction to Anthropological Theories and Theorists" (2018, 5th edition, Rowman and Littlefield) and he edited a companion collection of primary materials, "Visions of Culture: An Annotated Reader" (2018, 2nd edition, Rowman and Littlefield). Moore's writings have been translated into Spanish, French, Han Chinese, Turkish, and Croatian. Moore is also the editor of "Ñawpa Pacha: Journal of Andean Archaeology". Moore is also the editor for the series, Archaeologies of Landscape in the Americas, published by the University of New Mexico Press. Moore has been a Fellow in Precolumbian Studies at Harvard's Dumbarton Oaks Research Libraries and Collections in Washington D.C. (1992-93 and 2017), a senior scholar at the Sainsbury Centre for the Visual Arts at the University of East Anglia (1994), a Fellow at the Getty Research Institute (2001-2002), and a Fellow at the Institute of Advanced Studies, Durham University, UK (2013). He lives with his family in Long Beach, California, and provides food service to four cats.

This study of 801 multiple myeloma patients found that atrial fibrillation occurred in 5.5% within 90 days after autologous stem cell transplantation—nearly double previously reported rates—indicating disease‑specific risks. AF strongly predicted mortality from non‑relapse causes and may serve as a marker of physiological vulnerability, emphasizing the value of expanded pre‑transplant cardiac assessment and monitoring.

This week, join authors Shaan Khurshid and Julian S. Haimovich as they discuss their article "Incidence, Risk Factors, and Outcomes in Stressor-Associated Atrial Fibrillation: Insights From the VITAL-AF Trial." For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20260209.180892

On this episode of the CMAJ Podcast, Dr. Mojola Omole and Dr. Blair Bigham explore new evidence suggesting that rates of psychotic disorders are increasing in younger generations in Canada. Drawing on population-level data and broader psychiatric research, the episode examines how generational trends in psychosis intersect with substance use, social change, and the ongoing youth mental health crisis.Dr. Daniel Myran, a family physician and public health researcher at North York General Hospital, discusses findings from his CMAJ study, Incidence of psychotic disorders by birth cohort: a population-based cohort study in Ontario, Canada. He explains how overall rates of psychosis appear stable when populations are viewed as a whole, but mask a substantial rise among people born in the 1980s, 1990s, and early 2000s. Dr. Myran outlines possible contributors, including substance exposure, changes in diagnostic practices, and social determinants, and emphasizes the implications for early intervention psychosis programs and frontline care.The conversation then widens with Dr. Dafna Kahana, an associate professor of psychiatry at the University of Toronto and staff psychiatrist at CAMH, who draws on her article in the Journal of Psychiatry and Neuroscience, Are the kids alright? Making sense of the current youth mental health crisis in Canada through heuristic and data. She unpacks how social media use, sleep disruption, physical inactivity, pandemic-related isolation, and exposure to global crises may interact to affect youth mental health, while cautioning against oversimplified explanations or single-factor solutions.For clinicians, the takeaway is twofold: emerging generational shifts in psychosis warrant attention in both primary care and mental health planning, and addressing youth mental health requires a coordinated, multi-pronged approach that spans early identification, family support, and system-level investment rather than reliance on any single intervention.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Program notes:0:50 Rapid recovery of hearts for transplant after circulatory death1:50 Total ischemic time longer than 4 hours2:50 Typically reanimate3:50 Expanded to donors 40 years of age4:55 Do women with PCOS have increased risk for arrhythmia5:55 Incidence arrhythmia in these women increased risk6:50 An LLM to streamline transitions from primary to secondary care7:50 Used alone, with staff support, or control8:51 Decreased amount of time in the consult9:52 Things that accumulate data will be embraced10:12 Treating gout to prevent CVD11:12 Lowered in about a fourth of patients12:36 End

We discuss three pivotal studies showing how natural light wavelengths positively influence health from all-cause mortality to visual perfomance to blood glucose control in Type II diabetics.Jonathan Jarecki is a biomedical science sophomore with an interest in light and health, and host of Whole Health Podcast. SUPPORT MY WORK

In surgical residency, cases are long, expectations are high, and patient care always comes first. But then you become a parent, and suddenly you're navigating pregnancy risk, parental leave, and lactation logistics in a system that wasn't built for it. We've made meaningful progress over the past decade, but too many trainees still face becoming parents in residency without clear, consistent support. In this episode, join Dr. Kara Button with Dr. Arielle Kanters and Dr. Sarah Shubeck as they ask: How do we build a surgical workforce that's skilled, resilient—and genuinely supported as surgeon-parents? They'll share practical, evidence-based steps programs can take to make parental support the norm—not the exception.Hosts:Kara Button, DO — General Surgery Resident, Maine Medical Center; Behind the Knife Surgical Education FellowArielle Kanters, MD — Colorectal Surgeon; Associate Program Director, Colorectal Surgery Fellowship, Cleveland ClinicDr. Sarah Shubeck, MD — Assistant Professor of Surgery; Breast Surgical Oncologist, University of ChicagoReferences:Bamdad MC, Hughes DT, Englesbe M. Safe and supported pregnancy: A call to action for surgery chairs and program directors: A call to action for surgery chairs and program directors. Ann Surg. 2022;275(1):e1-e2. doi:10.1097/SLA.0000000000005181 https://pubmed.ncbi.nlm.nih.gov/34433187/Castillo-Angeles M, Atkinson RB, Easter SR, et al. Pregnancy during surgical training: Are residency programs truly supporting their trainees? J Surg Educ. 2022;79(6):e92-e102. doi:10.1016/j.jsurg.2022.06.011 https://pubmed.ncbi.nlm.nih.gov/35842402/Castillo-Angeles M, Smink DS, Rangel EL. Perspectives of general surgery program directors on paternity leave during surgical training. JAMA Surg. 2022;157(2):105-111. doi:10.1001/jamasurg.2021.6223 https://pubmed.ncbi.nlm.nih.gov/34851404/Kanters AE, Shubeck SP. The importance of parental leave and lactation support for surgeons. Clin Colon Rectal Surg. 2023;36(5):333-337. doi:10.1055/s-0043-1764288 https://pubmed.ncbi.nlm.nih.gov/37564351/Kling SM, Slashinski MJ, Green RL, Taylor GA, Dunham P, Kuo LE. Parental leave experiences for the non-childbearing general surgery resident parent: A qualitative analysis. Surgery. 2024;176(5):1320-1326. doi:10.1016/j.surg.2024.04.035 https://pubmed.ncbi.nlm.nih.gov/38910045/Mann H, Glazer T. Current state of safe pregnancy policies for the US surgical trainee. OTO Open. 2024;8(3):e172. doi:10.1002/oto2.172 https://pubmed.ncbi.nlm.nih.gov/39036338/Rangel EL, Smink DS, Castillo-Angeles M, et al. Pregnancy and motherhood during surgical training. JAMA Surg. 2018;153(7):644-652. doi:10.1001/jamasurg.2018.0153 https://pubmed.ncbi.nlm.nih.gov/29562068/Rangel EL, Castillo-Angeles M, Easter SR, et al. Incidence of infertility and pregnancy complications in US female surgeons. JAMA Surg. 2021;156(10):905-915. doi:10.1001/jamasurg.2021.3301 https://pubmed.ncbi.nlm.nih.gov/34319353/https://www.nytimes.com/2019/12/20/science/doctors-surgery-motherhood-medical-school.htmlhttps://behindtheknife.org/podcast/family-leave-during-surgical-training-a-discussion-with-abs-president-dr-jo-buyskePlease visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium:General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

You're in the middle of surgical residency, and you realize you need more than a few weeks away from clinical responsibilities. Maybe you need more time to be a parent, recover from an illness, care for family, learn a new skill, or simply create space to reflect and reset. What if you could complete five years of training over six calendar years by spreading that time out in a way that fits your life?  Join Dr. Kara Button with Dr. Joe Buyske, and Dr. Bridget Olson as they break down the 5-in-6 pathway including how it works, who it's for, and the real-world logistics that matter.Hosts:Kara Button, DO — General Surgery Resident, Maine Medical Center; Behind the Knife Surgical Education FellowJo Buyske, MD — President & CEO, American Board of SurgeryDr. Bridget Olsen, MD — General Surgery Resident, Maine Medical CenterReferences: Bamdad MC, Hughes DT, Englesbe M. Safe and supported pregnancy: A call to action for surgery chairs and program directors: A call to action for surgery chairs and program directors. Ann Surg. 2022;275(1):e1-e2. doi:10.1097/SLA.0000000000005181 https://pubmed.ncbi.nlm.nih.gov/34433187/Castillo-Angeles M, Atkinson RB, Easter SR, et al. Pregnancy during surgical training: Are residency programs truly supporting their trainees? J Surg Educ. 2022;79(6):e92-e102. doi:10.1016/j.jsurg.2022.06.011 https://pubmed.ncbi.nlm.nih.gov/35842402/Castillo-Angeles M, Smink DS, Rangel EL. Perspectives of general surgery program directors on paternity leave during surgical training. JAMA Surg. 2022;157(2):105-111. doi:10.1001/jamasurg.2021.6223 https://pubmed.ncbi.nlm.nih.gov/34851404/Kanters AE, Shubeck SP. The importance of parental leave and lactation support for surgeons. Clin Colon Rectal Surg. 2023;36(5):333-337. doi:10.1055/s-0043-1764288 https://pubmed.ncbi.nlm.nih.gov/37564351/Kling SM, Slashinski MJ, Green RL, Taylor GA, Dunham P, Kuo LE. Parental leave experiences for the non-childbearing general surgery resident parent: A qualitative analysis. Surgery. 2024;176(5):1320-1326. doi:10.1016/j.surg.2024.04.035 https://pubmed.ncbi.nlm.nih.gov/38910045/Mann H, Glazer T. Current state of safe pregnancy policies for the US surgical trainee. OTO Open. 2024;8(3):e172. doi:10.1002/oto2.172 https://pubmed.ncbi.nlm.nih.gov/39036338/Rangel EL, Smink DS, Castillo-Angeles M, et al. Pregnancy and motherhood during surgical training. JAMA Surg. 2018;153(7):644-652. doi:10.1001/jamasurg.2018.0153 https://pubmed.ncbi.nlm.nih.gov/29562068/Rangel EL, Castillo-Angeles M, Easter SR, et al. Incidence of infertility and pregnancy complications in US female surgeons. JAMA Surg. 2021;156(10):905-915. doi:10.1001/jamasurg.2021.3301 https://pubmed.ncbi.nlm.nih.gov/34319353/https://www.nytimes.com/2019/12/20/science/doctors-surgery-motherhood-medical-school.htmlhttps://behindtheknife.org/podcast/family-leave-during-surgical-training-a-discussion-with-abs-president-dr-jo-buyskePlease visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium:General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

Misinformation still finds its way into the conversation. Dorothy Gibbons and Dr. Raz dive into breast cancer myths, mammogram safety, risk factors, and common social media claims. They sort through concerns about bras, deodorants, cell phones, diet, and trauma. Evidence and screening guidelines guide the facts during this episode. Please consider sharing this episode, or making a donation at therose.org so more women receive breast cancer screening and care. Subscribe to Let’s Talk About Your Breasts on Apple Podcasts, Spotify, iHeart, and wherever you get your podcasts. Key Questions Answered 1. Does getting a mammogram increase your risk of developing breast cancer due to radiation exposure? 2. Why is there so much controversy and skepticism surrounding mammograms and breast cancer screening, especially compared to other screenings? 3. Is breast cancer only a concern for women with a family history of the disease? 4. Is breast cancer purely an older woman’s disease, or can younger women get it too? 5. Does wearing an underwire bra or any bra cause breast cancer? 6. Can deodorant use (especially with aluminum) lead to breast cancer? 7. Is carrying a cell phone in your bra (or close to your body) a cause of breast cancer? 8. Does hair dye or using plastic water bottles increase breast cancer risk? 9. Does hormone replacement therapy (HRT) increase breast cancer risk? 10. Can breast injury or trauma cause breast cancer? 11. Does obesity relate to breast cancer risk? 12. Can animals sense breast cancer in humans? 13. Are alternative treatments or internet trends (like ivermectin or bee venom) effective against breast cancer? 14. Is it important for patients to trust their doctor and treatment process? Timestamped Overview 00:00 Mammogram Radiation: Safe and Essential 04:22 Annual Screening Controversy Explained 08:28 Breast Cancer: Risks and Incidence 11:14 Impact of Treating Women's Diseases 13:52 Aluminum in Deodorant Safe 18:29 HRT Risks and Tapering Explained 25:52 Ivermectin Misuse and Clinical Trials 28:51 Health's Role in Cancer Prevention 29:47 Poison Necessary to Fight CancerSee omnystudio.com/listener for privacy information.

Le sujet fort de l'actualité foot du jour vu par Jérôme Rothen et la Dream Team.

On le pressentait en décembre, et cela se précise, la demande mondiale en cacao est orientée à la baisse. Cette tendance est donnée par un indicateur : le volume de fèves transformé par les broyeurs.   Les broyeurs sont les industriels qui transforment la fève brute en différents produits comme la pâte de cacao ou le beurre, qui sont ensuite vendus à l'industrie de l'agroalimentaire ou à des chocolatiers. Le chiffre des broyages est considéré comme l'indicateur le plus fiable pour évaluer la demande. Schématiquement, quand les Européens mangent moins de chocolat, les broyeurs européens ralentissent la cadence.  Les chiffres du quatrième trimestre 2025 qui viennent d'être publiés sont révélateurs : en Europe, les broyages ont baissé de plus de 8 % par rapport à la même période l'année dernière, selon l'Association européenne du cacao (ECA), de 5 % en Asie selon la Cocoa Association of Asia et de 13 % au Brésil. Il n'y a guère qu'aux États-Unis que les broyages se maintiennent. Ces baisses montrent une diminution de la demande, en raison du prix des fèves devenu trop élevé entre 2024 et 2025. Au Brésil, l'Association nationale des industries de transformation du cacao (AIPC) confirme une chute de la consommation nationale de produits chocolatés, cette chute dépassant 20 % pour certaines catégories comme la liqueur de cacao et le beurre de cacao. À lire aussiCacao: partenariat stratégique entre le broyeur de fêves malaisien GCB et le Conseil Café Cacao ivoirien Moins de demande, plus d'offre Si les broyages sont en baisse, cela veut dire qu'il restera plus de fèves brutes disponibles, pointe Carsten Fritsch, analyste de Commerzbank, qui prévoit un excédent de l'offre. Cette situation se reflète déjà dans les cours qui ont commencé à fléchir depuis mai 2025.    À leur sommet en 2024, les cours avaient frôlé les 12 000 dollars la tonne, ils peinent aujourd'hui à atteindre 5 000 dollars la tonne. Les annonces des dernières statistiques de broyages ne sont pas de nature à inverser la tendance et à faire remonter les prix. Incidence pour les producteurs ? Ce repli des cours mondiaux a une incidence sur les producteurs dans les pays où les prix sont libres et suivent le marché, comme par exemple au Cameroun. En revanche, chez le premier producteur mondial, la Côte d'Ivoire, la baisse des cours ne devrait pas avoir d'incidence immédiate car les producteurs touchent un prix qui est fixé en amont pour toute la campagne de cacao et qui est cette année plus haut que l'an dernier. Paradoxalement, ce prix garanti n'a pas suffi à les protéger : certains cacaoculteurs ivoiriens se retrouvent dans une situation très précaire, une partie de leur récolte n'ayant pas trouvé preneur depuis plusieurs semaines, en raison des difficultés financières de plusieurs acheteurs-exportateurs locaux. À lire aussiEn Côte d'Ivoire, le désarroi des planteurs de cacao face aux impayés

Qui dit fin d'année dit Gala des grands crus et des piquettes du Pharmascope! Ne manquez pas cette 9e édition du Gala où nous soulignons le départ d'Isabelle du Pharmascope et l'arrivée d'une nouvelle venue dans l'équipe.  ** Veuillez noter que cet épisode ne rencontre pas les critères d'admissibilité pour l'octroi d'unités de formation continue ou de crédits Mainpro+ ** Ressources pertinentes en lien avec l'épisode La catégorie « vitamine D » Lönnroos E, et coll. The Effect of Vitamin D3 Supplementation on the Incidence of Diagnosed Dementia Among Healthy Older Adults-The Finnish Vitamin D Trial. J Gerontol A Biol Sci Med Sci. 2025 Jun 10;80(7):glaf077. La catégorie « Étude simple mais intéressante » Gardner DM, et coll. Patient Self-Guided Interventions to Reduce Sedative Use and Improve Sleep: The YAWNS NB Randomized Clinical Trial. JAMA Psychiatry. 2024 Dec 1;81(12):1187-1197. La catégorie « Mieux-être » Collett G, et coll. Efficacy of Individual-Level Interventions to Mitigate the Risk for Burnout Among Health Care Professionals : A Systematic Review and Meta-analysis of Randomized Controlled Trials. Ann Intern Med. 2025 Nov 18. La catégorie « Techno » Heckman TG, Markowitz JC, Heckman BD. A Generative AI Chatbot for Mental Health Treatment: A Step in the Right Direction? NEJM AI. 2025 Aug 28;2(9). La catégorie « Nostalgie  » Díez-Vidal A, Arribas JR. How recent is recent? Retrospective analysis of suspiciously timeless citations. BMJ. 2025 Dec 11;391:e086941. La catégorie « Alimentaire  » Wong CX, et coll. Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial. JAMA. 2025 Nov 9:e2521056.

Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldwide. JAMA Review author Haeseong Park, MD, MPH, from the Dana Farber Cancer Institute, discusses this and more with JAMA Senior Editor Karen Lasser, MD, MPH. Related Content: Gastric Cancer

Aujourd'hui, Didier Giraud, éleveur de bovins, Fatima Aït Bounoua, prof de français, et Antoine Diers, consultant, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.

Shingles is a reactivation of the varicella‑zoster virus and poses a substantial burden, particularly for older adults and immunocompromised individuals. During this podcast, experts discuss the evolving epidemiology of shingles, distinguish between typical and atypical presentations across dermatologic, neurologic, and ophthalmic domains. Learners will gain insights into prevention strategies including vaccination and timely antiviral therapy to reduce complications. Claim CE and MOC credit at: https://bit.ly/4qkvOPU

Un nouvel épisode du Pharmascope est disponible! Dans ce 169e épisode dédié aux questions de nos auditeurs, Nicolas et Olivier tentent de pondre des réponses intelligentes à vos excellentes questions. Au menu : trouble d'usage lié à l'alcool, mélatonine et insuffisance cardiaque, taux sérique et hautes doses de vitamine D… et hypertension artérielle chez les plus jeunes! Les objectifs pour cet épisode sont les suivants: Discuter de la combinaison de naltrexone et de gabapentine en trouble d'usage lié à l'alcool Examiner les risques allégués de la mélatonine pour l'insuffisance cardiaque Discuter de la façon d'établir des seuils dits « normaux » de taux sériques de vitamine D Présenter les résultats de certaines études concernant l'innocuité de doses élevées de vitamine D Examiner les bénéfices du traitement de l'hypertension dans une population pédiatrique Ressources pertinentes en lien avec l'épisode Anton RF, et coll. Gabapentin combined with naltrexone for the treatment of alcohol dependence. Am J Psychiatry. 2011 Jul;168(7):709-17. Nnadi, et coll. Abstract 4371606: Effect of Long-term Melatonin Supplementation on Incidence of Heart Failure in Patients with Insomnia. Circulation. 2025; 152(Suppl_3). Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D. Sanders KM, et coll. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010 May 12;303(18):1815-22. Burt LA, et coll. Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. JAMA. 2019 Aug 27;322(8):736-745. Dionne JM, et coll; Hypertension Canada Guideline Committee. Hypertension Canada’s 2017 Guidelines for the Diagnosis, Assessment, Prevention, and Treatment of Pediatric Hypertension. Can J Cardiol. 2017 May;33(5):577-585. Chaturvedi S ,et coll. Pharmacological interventions for hypertension in children. Cochrane Database Syst Rev. 2014 Feb 1;2014(2):CD008117.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Ivabradine and Atrial Fibrillation Incidence: A Nested Matching Study.

ChairProfessor Yoshikatsu EtoAdvanced Clinical Research Center, Southern Tohoku Research Center for Neuroscience, Tokyo, JapanSpeakersDr Nicole Muschol International Center for Lysosomal Disorders (ICLD), University Medical Center, Hamburg-Eppendorf, GermanyProfessor Patrício AguiarInborn Errors of Metabolism Reference Center, Unidade Local de Saúde de Santa Maria / Faculty of Medicine, Lisbon University, PortugalDr Robert HopkinCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USAProfessor Yoshikatsu EtoWelcome to the Chiesi symposium. The title of this symposium, Catching the Clues, Changing the Cause of Lysosomal Storage Disease: Illuminating Complex Pathway of Rare Disease with Fabry Disease, Alpha-Mannosidosis, in Focus.This is a disclaimer: Following discussion does not focus on or depict any specific products manufactured by any pharmaceutical company. Patient cases are for medical discussion only and reflect the faculty own experience. They represent a typical clinical scenario. This presentation in part and whole may not be reproduced and not copy and not recording.I'm Dr. Eto from Tokyo, Japan, and the three distinguished speakers: Dr. Nicole Muschol from Germany, Eppendorf University. Professor Aguiar, the Portuguese, The Inborn Errors of Metabolism Reference Center, and also Professor Robert Hopkin, Cincinnati Children's Hospital, United States.The purpose of this symposium: Explore the patient journey across the LSD continuum, focusing on the unmet needs and diagnosis, and treatment initiation, and long-term management, and utilize case-based discussion focused on Alpha-mannosidosis, Fabry disease to highlight disease-specific challenges. Access where challenge persist in patient journey, and where tailored intervention can improve outcomes.Introduction of LSD patient journey with a spotlight on Fabry disease, Alpha-mannosidosis. Challenge to the diagnosis and then treatment and monitoring. Common LSD challenges over the patient journey, as shown here, and at least more than 70 different lysosomal diseases known. Incidence is about 1:5,000-1:8,000 in newborn. In the literature, much higher incidence.Multi-organ manifestation in many organ involved, and clinical heterogeneity are very complicated. The new screen method has been established already. Identify patient presymptomatically. That important by the newborn screening, something like that, early treatment essential. After the diagnosis treatment start, early and the presymptomatic treatment initiation, and usually delayed diagnosis, delayed treatment. Perceived burden of treatment may delay treatment start in patient milder form. Milder form is very difficult in the many cases, and particularly for Fabry disease also.After the treatment start and then monitoring, as you know, we discussed about the monitoring rely on the combination of clinical assessment, laboratory test, biomarkers, and imaging, and several other factors. Biomarkers and ADA drug assay lack standardization. Actually, the Alpha, and Beta, or [inaudible 00:03:19] Fabry disease, different ADA-titled measurement. Also, the patient experience between clinical visit, ERT infusion is under-reported.We discuss today two topics, two disease. Alpha-mannosidosis is very rare. In Japan, only few cases, and caused by the deficiency of Alpha-mannosidase, an accumulation of mannose-rich oligosaccharides and inheritance of autosomal-recessive. Age of onset is a very early period and younger period, adult period. Incidence approximately is very rare, 1:500,000.There are diseases we don't know exactly. If you have a treatment, maybe your incidence is much increased, and severe or attenuated [inaudible 00:04:09]. Alpha-mannosidosis is still a new disorder, and must differentiate from Mucopolysaccharidosis.On the other hand, the Fabry disease I think is very common. There are many discussion already in the past 20 years. Deficiency of a-Gal A, accumulation of Gb3⁵­­ or Lyso-Gb3, many other glycoprotein, which a terminal of a-Gal A, and X-chromosome. This is very important X-chromosomal inheritance. In case of this, and usually, female does not affect, but in case of Fabry, more of female also involved.First symptom, imagine at any age. Then incidence about 1:40,000-1:60,000. But depending on the country, as you know, classical form, about 1:40,000. Recently, after the newborn screening, late onset, very high incidence. About 90% of it—actually, we carried out a newborn screening in Japan—90% are late onset. But the clinical variety, so many clinical varieties, so incidents here, 1:3,000-1:4,000, something like that. Now, using the Alpha-mannosidosis and Fabry disease as an illustrative example, we will explore these disorders.

My guest is Dr. Thaïs Aliabadi, MD, board-certified OB/GYN, surgeon and leading expert in women's health. We discuss polycystic ovary syndrome (PCOS) and endometriosis, two very common yet frequently undiagnosed causes of female infertility. Dr. Aliabadi explains the symptoms, underlying causes and evidence-based treatments for both conditions, including supplement and lifestyle interventions. We also discuss breast cancer risk and screening, pregnancy, perimenopause and menopause, and the hormone tests that women should request. This conversation offers empowering, potentially life-changing information for women of all ages to take control of their hormone, reproductive and overall health. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman Lingo: https://hellolingo.com/huberman Our Place: https://fromourplace.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00 Thaïs Aliabadi 02:56 Why Endometriosis & Polycystic Ovary Syndrome (PCOS) Go Undiagnosed 08:16 Infertility, Tool: Early Screening 10:54 Sponsors: Lingo & Our Place 14:07 Women's Health Education Gap 15:24 PCOS Overview: Symptoms, Diagnosis, AMH, Disordered Eating 21:28 Irregular Periods, Teenage PCOS Diagnosis 24:36 Diagnosis, Pelvic Ultrasound; PCOS Naming 27:49 Thinning Hair & Acne; 4 PCOS Phenotypes; Mood & Treatment 35:54 Underlying Pillars of PCOS; HPA Axis, Androgens, Menstruation & Ovulation 40:30 Insulin Resistance & PCOS, Visceral Fat & Inflammation 46:30 Sponsors: AGZ by AG1 & Joovv 49:10 PCOS, Chronic Inflammation, Genetics & Lifestyle; Mood 52:31 PCOS, Fertility, Freezing Eggs, Tool: Egg Count & AMH Range By Age 58:34 Women's Health Education, AI, Clinicians; Cataracts Analogy 1:01:20 Stress; PCOS Treatment, Birth Control, Insulin Resistance & Metformin 1:06:44 PCOS Risk Calculator, Supplements, Lifestyle Factors; GLP-1s 1:12:32 Berberine, Metformin; GLP-1s, Food Anxiety & Alcohol 1:19:13 PCOS Prescriptions & Fertility; PCOS Co-Occurrence with Endometriosis 1:21:56 Sponsor: LMNT 1:23:16 PCOS Treatment, Freezing Eggs, Egg Quality; Advocate For Your Health 1:32:02 PCOS Key Takeaways: Symptoms, Tests, Supplements & Lifestyle 1:36:03 Undiagnosed Endometriosis, Fertility 1:39:26 Endometriosis: Symptoms, Diagnosis, Painful Periods, Infertility 1:42:30 Male vs Female Health Issues, Undiagnosed Endometriosis 1:47:01 Inflammation, Ectopic Implants, Chronic Pelvic Pain; Adenomyosis 1:50:36 Egg Quality, Endometriosis, Tools: Egg Counts; Pelvic Ultrasound 1:54:29 Sponsor: Function 1:56:13 Pain & Health Testing, Tool: Endometriosis Symptoms, Screening & Tests 2:01:32 Treatment, Surgery, Different Types of Endometriosis 2:05:22 Endometriosis Causes, Inflammation; Incidence, PCOS 2:11:58 Obstetrics & Gynecology Separation, Surgery 2:16:00 Endometriosis Key Takeaways: Symptoms, Treatment & Diagnosis 2:17:04 Treatment, Estrogen & Progesterone, Birth Control, GnRH Antagonists 2:22:39 Endometriosis Stage & Pain, Endometriosis Types 2:23:49 Pregnancy; Postpartum Depression, Menopause; Frustration for Patients 2:29:55 Fibroids, Surgery, Uterine Septum, Tool: Pelvic Ultrasound 2:34:05 Tool: Assessing Your & Partner's Fertility; Autoimmune Conditions 2:37:51 Breast Cancer, Tool: Lifetime Risk Calculator & Breast Imaging; Mastectomy 2:49:47 Endometriosis Tests, Autoimmune Disease; Brain Fog & Menopause; Inositol 2:53:06 Undiagnosed Infertility; PMDD Treatment; Fasting & Low-Carbohydrate Diets 2:57:21 Hair Loss & Perimenopause; Egg Quality; Endometriosis & Menopause 3:00:40 Increase Progesterone; Diet, Hormone & Menopause; Prolong Fertility 3:04:54 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Drs Joseph Mikhael and Sigurdur Y. Kristinsson discuss whether it is time to screen for multiple myeloma and what we can learn from the iStopMM study. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002717. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Multiple Myeloma https://emedicine.medscape.com/article/204369-overview Screening in Multiple Myeloma and Its Precursors: Are We There Yet? https://pubmed.ncbi.nlm.nih.gov/38175579/ Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM): A Population-Based Screening Study for Monoclonal Gammopathy of Undetermined Significance and Randomized Controlled Trial of Follow-Up Strategies https://pubmed.ncbi.nlm.nih.gov/34001889/ Identifying Associations Between Race and Gender in the Incidence and Mortality of Patients With Multiple Myeloma https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.e20052 Revisiting Wilson and Jungner in the Genomic Age: A Review of Screening Criteria Over the Past 40 Years https://pubmed.ncbi.nlm.nih.gov/18438522/ International Myeloma Foundation https://www.myeloma.org/ Prevalence of Monoclonal Gammopathy of Undetermined Significance https://pubmed.ncbi.nlm.nih.gov/16571879/ Monoclonal Gammopathy of Undetermined Significance https://www.ncbi.nlm.nih.gov/books/NBK507880/ Prevalence and Risk of Progression of Light-Chain Monoclonal Gammopathy of Undetermined Significance: A Retrospective Population-Based Cohort Study https://pubmed.ncbi.nlm.nih.gov/20472173/ Mode of Progression in Smoldering Multiple Myeloma: A Study of 406 Patients https://pubmed.ncbi.nlm.nih.gov/38228628/ Observation or Treatment for Smoldering Multiple Myeloma? A Systematic Review and Meta-Analysis of Randomized Controlled Studies https://pubmed.ncbi.nlm.nih.gov/40419473/

Five articles from the November 2025 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select the articles they want to read in full. The featured articles this month are, "Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic Rotator Cuff Repair: A Randomized, Double-Blinded, Placebo-Controlled Trial," "Delayed Surgery and Adenosine, Lidocaine, and Mg2+ Immunomodulatory Therapy Improve Joint Recovery in a Sex-Specific Manner After Anterior Cruciate Ligament Reconstruction in a Rat Model," "Comparison of Anchor Hole Enlargement Between Biodegradable and All-Soft Suture Anchors After Arthroscopic Bankart Repair: Longitudinal 2-Year Follow-up Study," "Sports Participation 25 Years After Anterior Cruciate Ligament Reconstruction: A Prospective Longitudinal Study Comparing Patients With Patellar Tendon and Hamstring Tendon Grafting to Uninjured Controls," and "Risk Profile for Cyclops Syndrome Necessitating Reoperation After Anterior Cruciate Ligament Reconstruction." Click here to read the articles.

Dr. Kenneth Ellenbogen, Deputy Editor of JACC: Clinical Electrophysiology, discusses Mental Disorders Following Implantable Cardioverter-Defibrillator Therapy: Incidence and Prognostic Implications in a Nationwide Cohort Study.

PodChatLive 203: Patients trust imaging more than clinicians, lower limb apophysitis incidence & risk factors, and The Centre for Podiatry HistoryContact us: getinvolved@podchatlive.comLinks from this episode:“It's hard to trust an individual, it's easier to trust an image”—patients with low back pain want imaging as a means of coping with uncertaintyIncidence of and Risk Factors for Lower Extremity Apophysitis in Children and Adolescents

While we're making progress in TREATING cancer, worldwide cancer INCIDENCE is soaring, especially among young people; New guidelines for colon cancer screening urge earlier start at age 45; Rates of peanut allergy are declining as more parents follow revised advice to introduce nuts earlier to kids; What's with all the buzz about methylene blue? Legalization and stronger pot are creating an epidemic of ER visits for uncontrolled vomiting, debilitating abdominal pain; New smart toilet gives you a report card on your poop; When Zoloft doesn't work for anxiety.

Brendan Kelly, Professor of Psychiatry at Trinity College Dublin

Commentary by Dr.  Jian'an Wang.

Commentary by Dr. Yoshihiro Miyamoto.

We review the diagnosis, risk stratification, & management of acute pulmonary embolism in the ED. Hosts: Vivian Chiu, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Acute_Pulmonary_Embolism.mp3 Download Leave a Comment Tags: Pulmonary Show Notes Core Concepts and Initial Approach Definition: Obstruction of pulmonary arteries, usually from a DVT in the proximal lower extremity veins (iliac/femoral), but may be tumor, air, or fat emboli. Incidence & Mortality: 300,000–370,000 cases/year in the USA, with 60,000–100,000 deaths annually. Mantra: “Don't anchor on the obvious. Always risk stratify and resuscitate with precision.” Risk Factors: Broad, including older age, inherited thrombophilias, malignancy, recent surgery/trauma, travel, smoking, hormonal use, and pregnancy. Clinical Presentation and Risk Stratification Presentation: Highly variable, showing up as anything from subtle shortness of breath to collapse. Acute/Subacute: Dyspnea (most common), pleuritic chest pain, cough, hemoptysis, and syncope. Patients are likely tachycardic, tachypneic, hypoxemic on room air, and may have a low-grade fever. Chronic: Can mimic acute symptoms or be totally asymptomatic. Pulmonary Infarction Signs: Pleuritic pain, hemoptysis, and an effusion. High-Risk Red Flags: Signs of hypotension (systolic blood pressure < 90 mmHg for over 15 minutes),

Program notes:0:40 Private equity takeover of hospitals1:40 Reduced salaries or staffing2:40 Patients likely to cost system3:30 Use of anti thymocyte globulin to slow down T1D in youth4:30 Diagnosed within 9 weeks prior5:30 Serum sickness in 82% of highest dose group6:30 Incidence increasing by 2% per year over 20 years7:00 Aspirin in CRC8:00 1100 patients with mutation9:00 Can this mutation be acquired?9:15 Alcohol and dementia10:15 Confounding factors relative to alcohol use11:15 Is there a safe level of consumption?12:40 End

Howie and Harlan are joined by Kate Heilpern, president of Yale New Haven Hospital, to discuss the innovation and adaption needed to lead NewYork-Presbyterian Hospital through the worst of the COVID-19 pandemic, and how Yale New Haven Health structures itself to provide quality care across five hospitals. Harlan reflects on the many biotech startups emerging from Yale; Howie responds to the Trump administration's assertion of a link between acetaminophen and autism.  Links: Biotech at Yale and Beyond “Investors Flock Back to Biotech After a Long, Cold Spell “Boom, Bust and Recover: What Happens Next as Biotech VC Cycle Resets”. “Pfizer to Buy Weight-Loss Drug Developer Metsera for Up to $7.3 Billion” Yale Ventures Health & Veritas Ep. 80: Josh Geballe: Turning Yale Innovation into Startups Yale Ventures Annual Report 2025 Cloverleaf Bio Allyx Therapeutics EvolveImmune Therapeutics Normunity Inozyme Pharma “BioMarin to buy rare disease drugmaker Inozyme for $270M” “Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018” Kate Heilpern “Yale New Haven Hospital announces new president” “Yale New Haven Health announces Katherine Heilpern, MD, as the new president of Yale New Haven Hospital” “Heilpern sees society reflected in the busy ER” “Meet the Heroes Fighting on the Front Lines Against Covid-19” “'Adrenaline, Duty, and Fear': Inside a New York Hospital Taking on the Coronavirus” Health & Veritas Ep. 116: Christopher O'Connor: Hospital Leadership in Trying Times “Saving America's ERs” “The 600 Pathways Yale New Haven Health Takes to Improved Care Delivery” Tylenol and Autism “Trump Issues Warning Based on Unproven Link Between Tylenol and Autism” “Trump links autism and Tylenol: is there any truth to it?” “Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability” “Study reveals no causal link between neurodevelopmental disorders and acetaminophen exposure before birth” “Does Stress Cause Ulcers?” “The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers” “The U.S. government has jumped the public health shark” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

This study examined outcomes of patients with atrial fibrillation treated with pulsed field ablation (PFA) and found a notably high incidence of phrenic nerve injury during the procedure. Most injuries were transient, but some persisted beyond the immediate peri-procedural period, raising concerns about long-term safety. The findings highlight the need for refined techniques and monitoring strategies to mitigate phrenic nerve injury risk with PFA. Please join host Michael S. Lloyd, MD, FHRS as he discusses the finding of this study with his guests Andrea M. Russo, MD, FHRS and Birju Rao, MD, Msci in Atlanta at the HRX Live 2025 conference. Learning Objective:  Examine outcomes of patients with atrial fibrillation treated with pulsed field ablation (PFA). Article AuthorsLouis Chéhirlian, MD, Linda Koutbi, MD, Julien Mancini, MD, PhD, Jérôme Hourdain, MD, Robin Richard-Vitton, MD, Marie Wilkin, MD, Jean-Claude Deharo, MD, Baptiste Maille, MD, PhD, Frédéric Franceschi, MD, PhD  Podcast Contributors Michael S. Lloyd, MD, FHRS | Emory University Andrea M. Russo, MD, FHRS | Cooper University Health Care Birju Rao, MD, Msci | Emory University Contributor Disclosure(s): M. Lloyd:   •Membership on Advisory Committees: Boston Scientific •Speaking/Teaching/Consulting: Medtronic, ArgaMedtech, Circa Scientific   B. Rao •Nothing relevant to disclose. A. Russo: •Honoraria/Speaking/Consulting: Pacemate, Abbott Medical, Medtronic, BiosenseWebster, Inc., AtriCure, Inc., Bayer Healthcare Pharmaceuticals, Boston Scientific •Research: Medtronic, Boston Scientific, Abbott, Bayer Healthcare Pharmaceuticals •Royalty Income: UpToDate,Inc. •Fellowship Support: Medtronic, Inc.   Bonus video of this episode, recorded at HRX Live 2025 in Atalnta, can be found on HRS365 and the HRX Innovation Hub.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Trends in Risk Factor Prevalence and Incidence of Acute Myocardial Infarction in Young Adults.

Joseph Mikhael, MD, and Krina K. Patel, MD, MSc, discuss considerations for CAR T-Cell therapy in multiple myeloma, including age, access, and bridging therapy. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002715. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Multiple Myeloma https://emedicine.medscape.com/article/204369-overview CARTITUDE-1 Final Results: Phase 1b/2 Study of Ciltacabtagene Autoleucel in Heavily Pretreated Patients With Relapsed/Refractory Multiple Myeloma https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.8009 Cilta-cel or Standard Care in Lenalidomide-Refractory Multiple Myeloma https://pubmed.ncbi.nlm.nih.gov/37272512/ Plain Language Summary of the KarMMa-3 Study of Ide-cel or Standard of Care Regimens in People With Relapsed or Refractory Multiple Myeloma https://pubmed.ncbi.nlm.nih.gov/38651976/ CAR T-Cell Therapy Toxicity https://www.ncbi.nlm.nih.gov/books/NBK592426/ Immunomodulatory Drugs in Multiple Myeloma: Mechanisms of Action and Clinical Experience https://pubmed.ncbi.nlm.nih.gov/28205024/ Incidence and Outcomes of Cytomegalovirus Reactivation After Chimeric Antigen Receptor T-Cell Therapy https://pubmed.ncbi.nlm.nih.gov/38838226/ Long-Acting Granulocyte Colony-Stimulating Factor in Primary Prophylaxis of Early Infection in Patients With Newly Diagnosed Multiple Myeloma https://pubmed.ncbi.nlm.nih.gov/35064823/ Revisiting the Role of Alkylating Agents in Multiple Myeloma: Up-to-Date Evidence and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/37244325/ Bispecific Antibodies for the Treatment of Relapsed/Refractory Multiple Myeloma: Updates and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/38660139/ FDA Eliminates REMS for Approved CAR T-Cell Therapies https://www.aabb.org/news-resources/news/article/2025/06/30/fda-eliminates-rems-for-approved-car-t-cell-therapies

In this new episode of Speaking of SurgOnc, Dr. Rick Greene discusses with Dr. Faina Nakhlis the upgrade rate to ductal carcinoma in situ or invasive cancer following excision for patients diagnosed with flat epithelial atypia on core biopsy, as reported in the article, "Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or Ductal Carcinoma In Situ in Patients Diagnosed with Flat Epithelial Atypia by Core Needle Biopsy (TBCRC 034).”

PennHIP for the Win on Reducing Incidence of Hip Dysplasia [caption id="attachment_14411" align="alignleft" width="399"] Dr. Karen Potter showing one of her German Wirehaired Pointers.[/caption] Host Laura Reeves is joined by Dr. Karen Potter to discuss the value of PennHIP evaluations to reduce the incidence of hip dysplasia in a breeding program. “While yes, I do PennHIP my dogs,” Potter said, “I typically will go back and still get an OFA score on them. So I have both avenues to look at as I'm going through my breeding. With Penn Hip, we're able to have a number that I can use in order to then go forward with breeding and that gives me an idea of if I have a dog with a higher laxity score to then breed that to a dog with a lower laxity score to try to continue to bring the number down in the offspring trying to improve the quality. “What the PennHIP program has done is they determined the laxity score, which is how much the hip joint is able to luxate during movement. We all know the hip is a ball and socket joint and the laxity being how much the ball can come out of the socket. And so when that ball comes out of the socket, in each step, they found that those forces and each concussive force is what we then develop osteoarthritis from. “When we're looking at a PennHIP score, we're looking for a score that is smaller, lower numbers are better. So it's a distraction value saying this is how much we can passively distract the hip from the socket. And I say passively because we're doing this while the dogs are under heavy sedation or anesthesia.” Listen in to take a deep dive into the world of PennHIP scores, how the test works, what it tells breeders and how to use the scores in a breeding program. For additional information on the studies done on the efficacy of this testing method check out this LINK.

In medicine, the hardest critic you'll face is often yourself. In this episode of BackTable Urology, Dr. Michelle Van Kuiken joins host Dr. Lindsay Hampson to unpack the realities of imposter syndrome in urology practice and discuss its impact on trainees and professionals --- This podcast is supported by: ⁠Ferring Pharmaceuticals⁠ --- SYNPOSIS Dr. Van Kuiken and Dr. Hampson explain the basics of imposter syndrome, its prevalence, and the many ways it can show up in medical training and practice. They also share candid personal experiences and practical strategies for overcoming self-doubt, from reframing negative thoughts to embracing feedback as a tool for growth. The doctors highlight the value of mentorship, peer support, and celebrating achievements, as well as the importance of creating a culture where vulnerability and open conversations are encouraged. --- TIMESTAMPS 00:00 - Introduction02:29 - Defining Imposter Syndrome04:24 - Personal Experiences with Imposter Syndrome08:44 - Impact of Imposter Syndrome in Medicine10:39 - Strategies to Overcome Imposter Syndrome13:59 - The Role of Mentorship16:28 - Gender and Mentorship in Medicine27:24 - Peer Support and Building Community32:13 - Final Thoughts and Takeaways --- RESOURCES Medical Trainees and the Dunning–Kruger Effect: When They Don't Know What They Don't Know:https://doi.org/10.4300/JGME-D-20-00134.1 Imposter Syndrome in Surgical Trainees: Clance Imposter Phenomenon Scale Assessment in General Surgery Residents:https://doi.org/10.1016/j.jamcollsurg.2021.07.681 Defining the Incidence of the Impostor Phenomenon in Academic Plastic Surgery: A Multi-Institutional Survey Study:https://doi.org/10.1097/prs.0000000000010821 Academic Urology Endowments and Leadership Roles are Disproportionately Held by Male Urologists:https://doi.org/10.1016/j.urology.2025.04.038 Implementation of a “Best Self” Exercise to Decrease Imposter Phenomenon in Residents:https://doi.org/10.4300/JGME-D-23-00873.1 Keep-Stop-Start Framework:https://meded.ucsf.edu/sites/meded.ucsf.edu/files/2024-06/TipSheet-Feedback.pdf Lean In: https://leanin.org/ W. Brad Johnson, PhD: https://www.wbradjohnson.com/

My guest is Dr. Sergiu Pașca, MD, professor of psychiatry and behavioral sciences at Stanford University. We discuss the biology and genetics of autism, why autism diagnoses are increasing and recent progress in using stem cells to understand and treat profound autism and other brain disorders. Dr. Pașca explains “organoids and assembloids”—human stem cell–derived tools he pioneered to study, treat and cure complex brain diseases. We also discuss ethical and safety issues with using gene editing and stem cells in humans. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Helix: https://helixsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00) Sergiu Pașca (02:08) Autism Spectrum Disorder, Incidence, Genetics (07:16) Is Autism More Common in Males? (09:35) Sponsors: David & Helix Sleep (11:56) Eye Contact in Babies, Fever; Proposed Causes of Autism; Genes (18:48) Genetic or Idiopathic Autism Diagnoses, Timothy Syndrome (21:37) Rise in Autism Diagnoses (26:46) Cause, Correlation & Neurological Disease; Schizophrenia, Do Vaccines Cause Autism? (31:34) Global Increase in Autism; Gene Therapy, CRISPR, Follistatin (41:05) Sponsors: AG1 & BetterHelp (43:41) Stem Cells, Ethics, Yamanaka Factors, Human Stem Cell Models (52:03) Umbilical Stem Cells; Stem Cell Injections & Dangers, Autistic Kids (59:30) Organoids, Modeling Brain Development, Intrinsic Development Timer (1:12:22) Assembloids, Brain Cell Migration & Circuit Formation, Self-Organization (1:21:22) Four-Part Assembloid, Sensory Assembloid, Pain Conditions (1:25:45) Sponsor: Function (1:27:33) Future Medical Therapies, Cell Banking, Immortalize Tissues, Rejuvenate Cells (1:34:56) Assembloids & Ethics, Importance of Nomenclature, Science Collaboration & Self-Correction (1:45:38) Cell Transplantation & Ethics, Timing (1:55:05) Genetic Testing for Parents, Genetic Penetrance (2:02:36) Assembloids, Timothy Syndrome, Epilepsy, Schizophrenia, Dystonia (2:14:30) Scientific Career, Walking, Art, Medical School (2:20:44) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Department of redundancy department

In this episode, my guest is Dr. Michael Kilgard, PhD, a professor of neuroscience at the University of Texas at Dallas and a leading expert on neuroplasticity and learning across the lifespan. We discuss the need for alertness, effortful focus, post-learning reflection and sleep to induce neuroplasticity, and how dopamine, acetylcholine, serotonin and norepinephrine are each involved. He explains the behavioral steps for neuroplasticity, as well as vagal nerve stimulation (VNS) and other therapies for tinnitus, stroke, depression, PTSD and paralysis. This episode ought to be of use to anyone interested in understanding the modern science of brain rewiring and learning to improve cognitive or motor skills or treat sensory or motor disorders. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Wealthfront*: https://wealthfront.com/huberman Carbon: https://joincarbon.com/huberman Function: https://functionhealth.com/huberman *This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27,‬ 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable‭ APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer. Timestamps (00:00) Michael Kilgard (03:24) Neuroplasticity (05:13) Child vs Adult Plasticity, Childhood Development & Learning (09:37) Sponsors: Eight Sleep & Wealthfront (12:41) Kids, Real vs Artificial Experiences & Balance, Video Games, Natural World (21:13) Social Media & Videos, Kids, Overstimulation & Development (33:42) Early Language Development, Passive vs Real Experiences, Kids & Adults (39:23) Sponsors: AG1 & Carbon (42:44) Learning & Plasticity Requirements; Focus, Friction, Rest & Reflection (52:24) Brain Connections, Complexity, Life Experiences & Plasticity (1:02:51) Learning, Reflection, Visualization, Testing (1:09:45) Experience Diversity & Time, Happiness, Life Appreciation (1:18:05) Sponsor: Function (1:19:53) Learning & Life Meaning (1:23:25) Neuromodulators, Brain Complexity, Synaptic Eligibility Trace & Learning (1:34:28) Synapses, Therapy for PTSD, Rewiring the Brain (1:39:01) Vagus Nerve Stimulation (VNS), Stroke, Spinal Cord Injury, Tinnitus, PTSD (1:47:33) Psychedelics, Neurostimulation, Importance of Timing (1:57:47) Electroconvulsive Therapy (ECT) & Major Depression (2:01:51) Psychedelics/SSRIs as Plasticity Tools, SSRIs & Bone Strength, Failed Clinical Trials (2:13:18) Can VNS Accelerate Learning? (2:16:01) VNS Surgery, Patient Use & Specificity, Closed-Loop Vagus Nerve Stimulation (2:18:18) Tinnitus Cause, Incidence & Self-Amplification; PTSD & Control (2:28:12) VNS for Tinnitus; Disease Complexity & Treatments, Lazy Eye (2:41:05) Complexity of Disease Treatments & Combination Therapies (2:48:50) Brain-Machine Interfaces, Information & Experiences; Closed-Loop Feedback; Resilience (2:59:09) Evolving Clinical Trials, Combination Treatments & Disease Complexity (3:05:21) Acknowledgements (3:07:04) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

About this Episode Episode 48 of “The 2 View” – Burn Tx, Marijuana & CV Risk, Ocular Syphilis, and HSV 1 & 2 Segment 1 – Thermal Burn Treatment Levin NJ, Erben Y, Li Y, et al. Edited by Muacevic A, Adler JR. A Systematic Review and Meta-Analysis Comparing Burn Healing Outcomes Between Silver Sulfadiazine and Aloe vera. Cureus. 2022;14(10):e30815. Accessed August 11, 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC9621733/ Aziz Z, Abdul Rasool Hassan B. The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials. Burns. 2017;43(1):50-57. Accessed August 11, 2025. https://pubmed.ncbi.nlm.nih.gov/27576926/ Segment 2A – Marijuana and Cardiovascular Risk Mohammadi L, Navabzadeh M, Jimenez-Tellez N, et al. Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use. JAMA Cardiol. Published online May 28, 2025. doi:10.1001/jamacardio.2025.1399. Accessed August 11, 2025. https://jamanetwork.com/journals/jamacardiology/fullarticle/2834540 Storck W, Elbaz M, Vindis C, et al. Eifling KP, Gaudio FG, Dumke C, et al. Cardiovascular risk associated with the use of cannabis and cannabinoids: a systematic review and meta-analysis. Heart. Published online June 17, 2025. doi:10.1136/heartjnl-2024-325429. Accessed August 11, 2025. https://pubmed.ncbi.nlm.nih.gov/40527600/ Page II RL, Allen LA, Kloner RA, et al. Medical Marijuana, Recreational Cannabis, and Cardiovascular Health: A Scientific Statement From the American Heart Association. Circulation. 2020;142(10);e131-152. https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000883 Segment 2B – Ocular Syphilis Zhou LR, Kirupaharan N, Birkenstock MK. Incidence and Prevalence of Syphilitic Uveitis and Associated Ocular Complications in the TriNetX Database. Am J Ophthalmol. 2025;277:387-394. https://www.sciencedirect.com/science/article/pii/S0002939425002843 Segment 3 - HSV 1 & 2 Langenberg AGM, Corey L, Ashley RL, et al. A Prospective Study of New Infections with Herpes Simplex Virus Type 1 and Type 2. N Engl J Med. 1999;341:1432-1438. https://www.nejm.org/doi/full/10.1056/nejm199911043411904 Lebrun-Vignes B, Bouzamondo A, Dupuy A, et al. A meta-analysis to assess the efficacy of oral antiviral treatment to prevent genital herpes outbreaks. J Am Acad Dermatol. 2007;57(20):238-246. Recurring Sources Center for Medical Education. http://ccme.org The Proceduralist. http://www.theproceduralist.org The Procedural Pause. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. http://www.thesgem.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to.

Interview with Sameer Jauhar, PhD, author of Incidence and Nature of Antidepressant Discontinuation Symptoms: A Systematic Review and Meta-Analysis. Hosted by John Torous, MD. Related Content: Incidence and Nature of Antidepressant Discontinuation Symptoms

Does psychiatric medication withdrawal exist — or is it just a myth?For anyone who's lived through it, the question alone can feel insulting.Psychiatric drug withdrawal is real. While the experience varies widely, for many, it's not “brief and mild” as many guidelines state it is. It can be intense, destabilizing, and often misunderstood. One of the most painful challenges is trying to determine whether what you're experiencing is withdrawal or relapse.Unfortunately, current clinical guidelines don't help. They often frame withdrawal as short-lived and minor, dismissing anything more severe as a return of illness. A potentially dangerous oversimplification that can leave patients feeling gaslit or unsupported.In this interview, Dr. Mark Horowitz, a psychiatrist and researcher who's both studied and experienced withdrawal firsthand, unpacks a new JAMA study that exemplifies the problem: guidelines built on inadequate evidence.In this episode, you'll hear:Why current drug withdrawal guidelines fall shortOverview of the new JAMA paper Incidence and Nature of Antidepressant Discontinuation SymptomsThe critical distinction between withdrawal and relapseThe truth about psychiatric drug withdrawalHow to design better research that reflects real-world experiencesWhy this information is often not reaching cliniciansHow we can conduct research that can better inform patient supportDr. Horowitz's story is one of courage and insight. As a clinician, he had no idea how wrong the guidelines were, until he tried coming off medication himself. What he discovered was far more complex than anything he'd been taught.To those navigating psychiatric medication withdrawal — especially in the face of oversimplified headlines and a healthcare system not yet equipped to support you — our hearts go out to you. You deserve care that is informed, compassionate, and grounded in lived experience as well as science. We won't stop until you have this.Expert Featured:Dr. Mark HorowitzX: @markhoroWebsite: https://markhorowitz.org/Resources Mentioned:Incidence and Nature of Antidepressant Discontinuation Symptoms A Systematic Review and Meta-Analysishttps://jamanetwork.com/journals/jamapsychiatry/article-abstract/28362623 Long-Term Psychiatric Medication Studieshttps://www.biologicalpsychiatryjournal.com/article/S0006-3223(98)00126-7/abstracthttps://journals.lww.com/intclinpsychopharm/abstract/2002/09000/discontinuation_symptoms__comparison_of_brief.2.aspxhttps://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/interruption-of-selective-serotonin-reuptake-inhibitor-treatment/F0241958CB073C51F366E2AABE636B5DOutro Clinichttps://www.outro.com/The Maudsley Desprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs

Have “get the epidural” circled on your birth plan? Or maybe you're curious but not sure if it's for you? In this episode, we're pulling back the curtain on what epidurals really are, how they work, what they don't do—and why preparation still matters deeply, even if you're planning on pain meds.We'll explore:What epidurals actually do (and don't do)How they're administered, and what it feels likeCommon misconceptions that leave people unpreparedSide effects and interventions that often come with themWhat to do if an epidural fails or doesn't fully workWhy birth prep is still crucial with or without medsThe essential tools every birthing person needs—no matter the planIf you're planning an epidural, undecided, or just open to options, this episode will leave you feeling informed, empowered, and ready to advocate for the birth you deserve.Resources Mentioned:The Path to a Powerful Birth – Clara's childbirth course blending research, mindfulness, advocacy, and surrender.Research Citations:Anim-Somuah, M., Smyth, R. M. D., & Cyna, A. M. (2018). Epidural versus non-epidural or no analgesia in labour. Cochrane Database of Systematic Reviews, (5), CD000331. https://doi.org/10.1002/14651858.CD000331.pub4Sharma, S. K., & McGrady, E. (2014). Early versus late initiation of epidural analgesia for labour. Cochrane Database of Systematic Reviews, (10), CD007238. https://doi.org/10.1002/14651858.CD007238.pub3Pan, P. H., Bogard, T. D., & Owen, M. D. (2004). Incidence and characteristics of failed conversion of labor epidural analgesia to cesarean delivery anesthesia: A retrospective analysis of 19,259 deliveries. Anesthesiology, 100(4), 908–914. https://doi.org/10.1097/00000542-200404000-00014Torvaldsen, S., Roberts, C. L., Simpson, J. M., Thompson, J. F., & Ellwood, D. A. (2006). Intrapartum epidural analgesia and breastfeeding: A prospective cohort study. International Breastfeeding Journal, 1, 24. https://doi.org/10.1186/1746-4358-1-24Beilin, Y., Bodian, C. A., Weiser, J., Hossain, S., Arnold, I., Feierman, D. E., & Martin, G. (2005). Effect of labor analgesia with and without fentanyl on infant breastfeeding: A prospective, randomized, double-blind study. Anesthesiology, 103(6), 1211–1217. https://doi.org/10.1097/00000542-200512000-00018Get 20% off your first monthly subscription with NEEDED Vitamins 

The incidence of early onset colorectal cancer (EOCRC) has been rising prompting the change in change in screening guidelines to 45 years of age for average risk patients. Join us for an in-depth discussion with guest speakers Dr. Andrea Cercek and Dr. Nancy You, where we provide a comprehensive look at the growing challenge of EOCRC. Hosts: - Dr. Janet Alvarez - General Surgery Resident at New York Medical College/Metropolitan Hospital Center - Dr. Wini Zambare – General Surgery Resident at Weill Cornell Medical Center/New York Presbyterian - Dr. Phil Bauer, Graduating Colorectal Surgical Oncology Fellow at Memorial Sloan Kettering Cancer Center  - Dr. J. Joshua Smith MD, PhD, Chair, Department of Colon and Rectal Surgery at MD Anderson Cancer Center - Dr. Andrea Cercek - Gastrointestinal Medical Oncologist at Memorial Sloan Kettering Cancer Center - Dr. Y. Nancy You, MD MHSc - Professor, Department of Colon and Rectal Surgery at MD Anderson Cancer Center Learning objectives:  - Describe trends in incidence of colorectal cancer, with emphasis on the rise of EOCRC. - Identify age groups and demographics most affected by EOCRC. - Summarize USPSTF recommendations for colorectal cancer screening. - Distinguish between screening methods (e.g., colonoscopy, FIT-DNA) and their sensitivity. - Understand treatment approaches for colon and rectal cancer (CRC) - Understand the role of mismatch repair (MMR) status in guiding treatment. - Outline the importance of genetic counseling and testing in young patients. - Discuss racial, ethnic, and socioeconomic disparities in CRC incidence and outcomes. - Describe the impact of cancer treatment on fertility and sexual health. -  Review fertility preservation options. - Identify the value of integrated care teams for young CRC patients. References: 1.         Siegel, R. L. et al. Colorectal Cancer Incidence Patterns in the United States, 1974–2013. JNCI J. Natl. Cancer Inst. 109, djw322 (2017). https://pubmed.ncbi.nlm.nih.gov/28376186/ 2.         Abboud, Y. et al. Rising Incidence and Mortality of Early-Onset Colorectal Cancer in Young Cohorts Associated with Delayed Diagnosis. Cancers 17, 1500 (2025). https://pubmed.ncbi.nlm.nih.gov/40361427/ 3.         Phang, R. et al. Is the Incidence of Early-Onset Adenocarcinomas in Aotearoa New Zealand Increasing? Asia Pac. J. Clin. Oncol.https://pubmed.ncbi.nlm.nih.gov/40384533/ 4.         Vitaloni, M. et al. Clinical challenges and patient experiences in early-onset colorectal cancer: insights from seven European countries. BMC Gastroenterol. 25, 378 (2025). https://pubmed.ncbi.nlm.nih.gov/40375142/ 5.         Siegel, R. L. et al. Global patterns and trends in colorectal cancer incidence in young adults. (2019) doi:10.1136/gutjnl-2019-319511. https://pubmed.ncbi.nlm.nih.gov/31488504/ 6.         Cercek, A. et al. A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. J. Natl. Cancer Inst. 113, 1683–1692 (2021). https://pubmed.ncbi.nlm.nih.gov/34405229/ 7.         Zheng, X. et al. Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer. JNCI J. Natl. Cancer Inst. 113, 543–552 (2021). https://pubmed.ncbi.nlm.nih.gov/33136160/ 8.         Standl, E. & Schnell, O. Increased Risk of Cancer—An Integral Component of the Cardio–Renal–Metabolic Disease Cluster and Its Management. Cells 14, 564 (2025). https://pubmed.ncbi.nlm.nih.gov/40277890/ 9.         Muller, C., Ihionkhan, E., Stoffel, E. M. & Kupfer, S. S. Disparities in Early-Onset Colorectal Cancer. Cells 10, 1018 (2021). https://pubmed.ncbi.nlm.nih.gov/33925893/ 10.       US Preventive Services Task Force. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA 325, 1965–1977 (2021). https://pubmed.ncbi.nlm.nih.gov/34003218/ 11.       Fwelo, P. et al. Differential Colorectal Cancer Mortality Across Racial and Ethnic Groups: Impact of Socioeconomic Status, Clinicopathology, and Treatment-Related Factors. Cancer Med. 14, e70612 (2025). https://pubmed.ncbi.nlm.nih.gov/40040375/ 12.       Lansdorp-Vogelaar, I. et al. Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates. Cancer Epidemiol. Biomarkers Prev. 21, 728–736 (2012). https://pubmed.ncbi.nlm.nih.gov/22514249/ 13.       Ko, T. M. et al. Low neighborhood socioeconomic status is associated with poor outcomes in young adults with colorectal cancer. Surgery 176, 626–632 (2024). https://pubmed.ncbi.nlm.nih.gov/38972769/ 14.       Siegel, R. L., Wagle, N. S., Cercek, A., Smith, R. A. & Jemal, A. Colorectal cancer statistics, 2023. CA. Cancer J. Clin. 73, 233–254 (2023). https://pubmed.ncbi.nlm.nih.gov/36856579/ 15.       Jain, S., Maque, J., Galoosian, A., Osuna-Garcia, A. & May, F. P. Optimal Strategies for Colorectal Cancer Screening. Curr. Treat. Options Oncol. 23, 474–493 (2022). https://pubmed.ncbi.nlm.nih.gov/35316477/ 16.       Zauber, A. G. The Impact of Screening on Colorectal Cancer Mortality and Incidence: Has It Really Made a Difference? Dig. Dis. Sci. 60, 681–691 (2015). https://pubmed.ncbi.nlm.nih.gov/25740556/ 17.       Edwards, B. K. et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544–573 (2010). https://pubmed.ncbi.nlm.nih.gov/19998273/ 18.       Cercek, A. et al. Nonoperative Management of Mismatch Repair–Deficient Tumors. New England Journal of Medicine 392, 2297–2308 (2025). https://pubmed.ncbi.nlm.nih.gov/40293177/ 19.       Monge, C., Waldrup, B., Carranza, F. G. & Velazquez-Villarreal, E. Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations. Cancers 17, 1325 (2025). https://pubmed.ncbi.nlm.nih.gov/40282501/ 20.       Monge, C., Waldrup, B., Carranza, F. G. & Velazquez-Villarreal, E. Ethnicity-Specific Molecular Alterations in MAPK and JAK/STAT Pathways in Early-Onset Colorectal Cancer. Cancers 17, 1093 (2025). https://pubmed.ncbi.nlm.nih.gov/40227607/ 21.       Benson, A. B. et al. Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Compr. Cancer Netw. JNCCN 19, 329–359 (2021). https://pubmed.ncbi.nlm.nih.gov/33724754/ 22.       Christenson, E. S. et al. Nivolumab and Relatlimab for the treatment of patients with unresectable or metastatic mismatch repair proficient colorectal cancer. https://pubmed.ncbi.nlm.nih.gov/40388545/ 23.       Dasari, A. et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. The Lancet 402, 41–53 (2023). https://pubmed.ncbi.nlm.nih.gov/37331369/ 24.       Strickler, J. H. et al. Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study. Lancet Oncol. 24, 496–508 (2023). https://pubmed.ncbi.nlm.nih.gov/37142372/ 25.       Sauer, R. et al. Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer. N. Engl. J. Med. 351, 1731–1740 (2004). https://pubmed.ncbi.nlm.nih.gov/15496622/ 26.       Cercek, A. et al. Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer. JAMA Oncol. 4, e180071 (2018). https://pubmed.ncbi.nlm.nih.gov/29566109/ 27.       Garcia-Aguilar, J. et al. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. J. Clin. Oncol. 40, 2546–2556 (2022). https://pubmed.ncbi.nlm.nih.gov/35483010/ 28.       Schrag, D. et al. Preoperative Treatment of Locally Advanced Rectal Cancer. N. Engl. J. Med. 389, 322–334 (2023). https://pubmed.ncbi.nlm.nih.gov/37272534/ 29.       Kunkler, I. H., Williams, L. J., Jack, W. J. L., Cameron, D. A. & Dixon, J. M. Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer. N. Engl. J. Med. 388, 585–594 (2023). https://pubmed.ncbi.nlm.nih.gov/36791159/ 30.       Jacobsen, R. L., Macpherson, C. F., Pflugeisen, B. M. & Johnson, R. H. Care Experience, by Site of Care, for Adolescents and Young Adults With Cancer. JCO Oncol. Pract. (2021) doi:10.1200/OP.20.00840. https://pubmed.ncbi.nlm.nih.gov/33566700/ 31.       Ruddy, K. J. et al. Prospective Study of Fertility Concerns and Preservation Strategies in Young Women With Breast Cancer. J. Clin. Oncol. (2014) doi:10.1200/JCO.2013.52.8877. https://pubmed.ncbi.nlm.nih.gov/24567428/ 32.       Su, H. I. et al. Fertility Preservation in People With Cancer: ASCO Guideline Update. J. Clin. Oncol. 43, 1488–1515 (2025). https://pubmed.ncbi.nlm.nih.gov/40106739/ 33.       Smith, K. L., Gracia, C., Sokalska, A. & Moore, H. Advances in Fertility Preservation for Young Women With Cancer. Am. Soc. Clin. Oncol. Educ. Book 27–37 (2018) doi:10.1200/EDBK_208301. https://pubmed.ncbi.nlm.nih.gov/30231357/ 34.       Blumenfeld, Z. How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries. The Oncologist 12, 1044–1054 (2007). 35.       Bhagavath, B. The current and future state of surgery in reproductive endocrinology. Curr. Opin. Obstet. Gynecol. 34, 164 (2022). 36.       Ribeiro, R. et al. Uterine transposition: technique and a case report. Fertil. Steril. 108, 320-324.e1 (2017). 37.       Yazdani, A., Sweterlitsch, K. M., Kim, H., Flyckt, R. L. & Christianson, M. S. Surgical Innovations to Protect Fertility from Oncologic Pelvic Radiation Therapy: Ovarian Transposition and Uterine Fixation. J. Clin. Med. 13, 5577 (2024). 38.       Holowatyj, A. N., Eng, C. & Lewis, M. A. Incorporating Reproductive Health in the Clinical Management of Early-Onset Colorectal Cancer. JCO Oncol. Pract. 18, 169–172 (2022). ***Behind the Knife Colorectal Surgery Oral Board Audio Review: https://app.behindtheknife.org/course-details/colorectal-surgery-oral-board-audio-review Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

In this compelling episode of the Bendy Bodies Podcast, Dr. Linda Bluestein is joined by her longtime mentor and internationally respected EDS expert, Dr. Pradeep Chopra. Together, they tackle some of the most frustrating—and frequently misunderstood—questions surrounding hypermobile Ehlers-Danlos Syndrome (hEDS). From major flaws in the 2017 diagnostic criteria to the hidden surgical risks that could lead to serious complications like CCI (craniocervical instability), this conversation dives deep into clinical insights and lived experience. Listeners will also hear the surprising story of how Dr. Chopra helped inspire Dr. Bluestein to open her own practice. Whether you're a patient, parent, or provider, this episode just might change how you see joint hypermobility and connective tissue disorders forever. Takeaways Why men and boys may be getting overlooked by the current EDS diagnostic model The difference between dislocations and subluxations—and why that matters A surprising source of CCI: what your dentist, surgeon, and anesthesiologist may not know The 2017 criteria: well-meaning, but are they dangerously outdated? What every hypermobile patient should bring to their next surgery (yes, it's a hack) Want to follow along? Find the episode transcript here. References: Episode 70: https://youtu.be/BoRyQh12X2c Episode 71: https://youtu.be/yDT3JTzfiJk Episode 72: https://youtu.be/CYhnKkVjIxM Episode 73: https://youtu.be/2OxtZGNswfo Episode 77: https://youtu.be/d9A1aJB5GRo Episode 151: https://youtu.be/ho0rRcjUobI Perioperative Care in Patients with EDS by Linda Bluestein & Pradeep Chopra: https://www.scirp.org/journal/paperinformation?paperid=97524 Diagnostic Criteria: https://www.bendybodiespodcast.com/p/diagnostic-criteria-checklist/ The Incidence of Misdiagnosis in Patients with EDS: https://www.mdpi.com/2227-9067/12/6/698 Living Well with Orthostatic Intolerance by Peter C. Rowe: https://www.amazon.com/shop/hypermobilitymd/list/2LQLPARJY3CDS?linkCode=sl2&tag=onamzlindablu-20&ref_=aip_sf_list_spv_ofs_mixed_d 2023 Diagnostic Framework: https://www.ehlers-danlos.com/diagnosis/new-diagnostic-framework-for-pediatric-joint-hypermobility-v2/ Want more Dr. Pradeep Chopra?  Website: https://www.painri.com/ Contact Dr. Chopra's Office: snapa102@gmail.com Want more Dr. Linda Bluestein, MD? Website:  ⁠⁠https://www.hypermobilitymd.com/⁠⁠. YouTube: ⁠⁠⁠youtube.com/@bendybodiespodcast⁠⁠⁠  Instagram: ⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠  Facebook: ⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠  X: ⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠  LinkedIn: ⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠  Newsletter: ⁠⁠⁠https://hypermobilitymd.substack.com/⁠⁠⁠ Shop my Amazon store ⁠⁠⁠https://www.amazon.com/shop/hypermobilitymd⁠⁠⁠ Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority! Use this affiliate link for Algonot to get an extra 5% off your entire order: ⁠⁠https://algonot.com/coupon/bendbod/⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to episode 183 of Growers Daily! We cover: garlic rust and what to do about it, how to tell if your soil is healthy, and it's feedback friday! We are a Non-Profit! 

My guest is Dr. Roger Seheult, M.D., a board-certified physician in internal medicine, pulmonary diseases, critical care, and sleep medicine at Loma Linda University. We discuss the powerful benefits of light therapy, including infrared light, red light, and sunlight, for improving mitochondrial function in all the body's organs. We also explore ways to reduce the risk of influenza, colds, and other illnesses that affect the lungs, sinuses, and gut. Topics include the flu shot, whether handwashing truly prevents illness transmission, and treatments for long COVID and mold toxicity. We review the efficacy of N-acetylcysteine (NAC), the power of hydrotherapy for combating infections, and strategies for improving sleep and overall health. Additionally, we discuss air quality. This episode provides actionable, science-based tools for preventing and treating infectious illnesses. Read the full show notes for this episode at hubermanlab.com. Sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Our Place: https://fromourplace.com/huberman Timestamps 00:00:00 Dr. Roger Seheult 00:02:16 Avoiding Sickness, Immune System, Tool: Pillars of Health, NEWSTART 00:08:03 Sponsors: Joovv & Eight Sleep 00:10:46 Sunlight, Mitochondria, Tool: Infrared Light & Melatonin 00:19:09 Melatonin Antioxidant, Reactive Oxygen Species (ROS)/Free Radicals 00:26:38 Infrared Light, Green Spaces, Health & Mortality 00:31:35 Infrared Light, Mitochondrial Dysfunction, Disease 00:38:46 Sunlight & Cancer Risk?, Tools: UV Light, Clothing & Sunlight Exposure 00:41:01 Sponsors: AG1 & LMNT 00:43:32 Sunlight, Incidence of Influenza or COVID 00:48:41 Tools: Sunlight Exposure Duration, Winter Months 00:55:18 Infrared Lamps?, Winter Sunlight Exposure; Obesity & Metabolic Dysfunction 00:59:48 Cloudy Days; Sunlight, Primitive Therapy, Hospitals 01:11:33 Sponsor: Function 01:13:21 Artificial Lights, Hospitals & Light Therapy?, ICU Psychosis 01:22:16 Sleep & Darkness, Tools: Eye Mask, Bathroom Navigation; Meals & Light 01:28:27 Influenza, Flu Shots, Swiss Cheese Model; Flu Shot Risks? 01:38:13 Masks?, Flu; Handwashing 01:42:16 Sponsor: Our Place 01:43:57 Water, Sodium; Innate Immune System, Fever & Hydrotherapy 01:53:46 Fever, Heat Hydrotherapy, Interferon & Immune System 01:58:25 Cold Hydrotherapy, Vasoconstriction & White Blood Cells 02:09:56 N-Acetyl Cysteine (NAC), Glutathione, White Clots, Flu, Covid 02:19:28 Tool: NAC Dose & Regimen; Mucous, Flu Symptoms 02:25:25 Zinc Supplementation, Copper; Exogenous Interferon 02:28:40 Eucalyptus Oil, Inhalation 02:32:22 Air, Smoking, Vaping, Nicotine Gum 02:36:49 Fresh Air, Forest Bathing, Tool: Go Outdoors 02:40:09 Nature vs Inside Environments, Dark Days/Bright Nights Problem 02:52:38 Long COVID, Mitochondrial Dysfunction, Intermittent Fasting, Sunlight 03:00:43 Covid & Varied Severity, Smell Loss Recovery 03:05:04 Mold Toxicity, Lungs, Germ vs Terrain Theory, Immunocompromised 03:11:46 Trust, Spirituality, Community, Faith; Forgiveness 03:19:46 Hospital Admission, Tool: Asking Questions 03:25:42 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures