Species of virus
POPULARITY
In this episode, Tzu-Hao (Howard) Lee, MD; Tatyana Kushner, MD, MSCE; and patient advocate Andrew Reynolds discuss hepatitis C virus (HCV) care in men who have sex with men and pregnant people, including:HCV disease burden in the United StatesScreening recommendations Strategies to overcome barriers to HCV screeningTreatment recommendations, including simplified treatment guidance and considerations for pregnant peopleStrategies to improve treatment uptakePresenters:Tzu-Hao (Howard) Lee, MDAssistant ProfessorSection of Gastroenterology and Hepatology, Department of MedicineDivision of Abdominal Transplant, Department of SurgeryBaylor College of MedicineHouston, TexasTatyana Kushner, MD, MSCEAssociate ProfessorDivision of Gastroenterology/HepatologyDepartment of Obstetrics & GynecologyWeill Cornell MedicineNew York, New YorkAndrew ReynoldsDirector, Health of People Who Use DrugsSan Francisco AIDS FoundationSan Francisco, CaliforniaTo access all of our new podcast episodes, subscribe to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify. Link to full program:https://bit.ly/4j973TNDownloadable slides: https://bit.ly/4gXuBcu
In this episode, Stacey B. Trooskin, MD, PhD, MPH, Mark S. Sulkowski, MD, FIDSA, FAASLD, and Ronni Marks discuss hepatitis C virus (HCV) screening and treatment, focusing on people who use drugs, and highlight the following topics:Screening recommendationsStrategies to improve HCV screeningHCV testingTreatment goalsStrategies to improve HCV treatment uptakePresenters:Stacey B. Trooskin, MD, PhD, MPHExecutive Medical OfficerMazzoni CenterFaculty, University of PennsylvaniaPerelman School of MedicinePhiladelphia, PennsylvaniaMark S. Sulkowski, MD, FIDSA, FAASLDProfessor of MedicineDirector, Division of Infectious Diseases Johns Hopkins Bayview Medical CenterJohns Hopkins University School of MedicineBaltimore, MarylandRonni MarksFounder/Director, The Hepatitis C Mentor and Support Group (HCMSG)Patient AdvocateNew York, New YorkLink to full program:https://bit.ly/4grbwPT
Today we sat down with Dr. Charles Rice, the Maurice R. and Corinne P. Greenberg Professor in Virology at Rockefeller University. Dr. Rice is an expert in RNA viruses, viruses that use RNA as opposed to DNA in their genome, and studies the body's innate immune response to infection. However, he is most known for his work on Hepatitis C Virus, which causes liver disease and cirrhosis if untreated. Dr. Rice was the first to achieve a successful cell culture of Hepatitis C, create a functional clone of the virus, and prove that the virus causes the disease. This work led to the first effective treatments for Hepatitis C, saving millions of lives worldwide and earning Dr. Rice and his collaborators the 2020 Nobel Prize in Medicine or Physiology. Title music: World Is Holding Hands by WinnieTheMoog https://creativecommons.org/licenses/by/4.0/legalcode
In this episode, we review the high-yield topic of Hepatitis C Virus from the Microbiology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
In this episode, Stefan Zeuzem, MD, discusses new data on viral hepatitis presented at EASL 2023, including:Hepatitis B virusDurability of response with bepirovirsenHBsAg loss with siRNA VIR-2218 combined with either VIR-3434 (novel monoclonal antibody) or pegIFN-alfaHepatitis delta virus96-week follow-up of immediate vs delayed bulevirtideOff-treatment response for lonafarnib + ritonavir ± pegIFN-alfa Safety and efficacy outcomes with siRNA JNJ-3989 + nucleos(t)ide analogueHepatitis C virusCollaborative service at opiate substitution treatment clinic to improve linkage to care in IrelandNurse-led test-and-treat program to increase screening and diagnosis at female prisons in the United KingdomFIND-C study using machine learning to improve screening-to-diagnosis ratio using clinical factors and social determinants of healthPresenter:Stefan Zeuzem, MDProfessor of Medicine Chief, Department of Medicine JW Goethe University Hospital Frankfurt, GermanyLink to full program: https://bit.ly/3JQQj3J
Marina Berenguer, MD, PhD - Treating Hepatitis C Virus in Special Populations: Pregnant Women, Children and Adolescents
Marina Berenguer, MD, PhD - Treating Hepatitis C Virus in Special Populations: Pregnant Women, Children and Adolescents
Marina Berenguer, MD, PhD - Treating Hepatitis C Virus in Special Populations: Pregnant Women, Children and Adolescents
Marina Berenguer, MD, PhD - Treating Hepatitis C Virus in Special Populations: Pregnant Women, Children and Adolescents
Marina Berenguer, MD, PhD - Treating Hepatitis C Virus in Special Populations: Pregnant Women, Children and Adolescents
Marina Berenguer, MD, PhD - Treating Hepatitis C Virus in Special Populations: Pregnant Women, Children and Adolescents
In this episode, Stefan Zeuzem, MD, discusses new viral hepatitis data from AASLD 2022, including:Hepatitis BPrevention of HBV vertical transmission when HBIg is unavailableTherapeutic vaccination for HBV cureAntiviral therapy to prevent HCC in patients with CHB in the indeterminate phaseHepatitis deltaHDV prevalence in ethnically diverse, urban, safety-net populationsBulevirtide ± pegIFN-α2a for chronic HDV in the French cATU studyBulevirtide monotherapy for patients with HDV and compensated cirrhosis in the HEP4Di studyHDV functional cure with lonafarnib-based therapyHepatitis CIntegrated community HCV service for PWUD: the ITTREAT studyHelios-3 study of treatment of people with HCV by specialists or nonspecialistsRisk of HCC after SVR in patients with HCVPresenter:Stefan Zeuzem, MDProfessor of MedicineChief, Department of Medicine I JW Goethe University Hospital Frankfurt, GermanyFollow along with the downloadable slideset at: https://bit.ly/3FxIOwZLink to full program: https://bit.ly/3Y1tD6f
In this episode, Nancy Reau, MD, shares her thoughts on the most practice-changing viral hepatitis data from AASLD 2022, including:Novel therapeutics for HBVHCV management strategiesHDV screening and linkage to careFatty liver disease in persons with viral hepatitisUse of statins to decrease morbidity and mortality in persons with liver diseasePresenter:Nancy Reau, MDProfessor of MedicineChief, Section of HepatologyAssociate DirectorSolid Organ TransplantationRichard B. Capps Chair of HepatologyRush University Medical CenterChicago, IllinoisLink to full program: https://bit.ly/3Y1tD6f
In this episode, Stefan Zeuzem, MD, discusses new viral hepatitis data from EASL 2022, including:Novel HBV therapeutics, including the REEF-2, B-Clear, and SAVE-1 studiesHBV cure from the Everest Project in ChinaHDV therapeutics from MYR301 and a study of bulevirtide in patients with cirrhosis and portal hypertensionHCV retreatment in patients with prior direct-acting antiviral therapy failurePresenter: Stefan Zeuzem, MDProfessor of MedicineChief, Department of Medicine I JW Goethe University Hospital Frankfurt, GermanyFollow along with the downloadable slideset at:https://bit.ly/3yJAruDLink to full program: https://bit.ly/3AjCNBC
In this episode, Nancy Reau, MD, discusses new viral hepatitis data from EASL 2022, including:Novel therapeutics for HBVTherapeutic vaccination for HBVEmerging treatment options for HDVHCV care cascadeHCC monitoring after HCV curePresenter: Nancy Reau, MDProfessor of MedicineChief, Section of HepatologyAssociate Director, Solid Organ TransplantationRichard B. Capps Chair of HepatologyRush University Medical CenterChicago, IllinoisFollow along with the downloadable slideset at: https://bit.ly/3yJAruDLink to full program:https://bit.ly/3IeUapm
The World Health Organization estimated that during 2019, 58 million people worldwide were living with the Hepatitis C virus (HCV) which causes inflammation of the liver. All types of hepatitis can be controlled or prevented. There is a cure for Hepatitis C; however, HCV infection is often undiagnosed because it remains asymptomatic until symptoms appear that are related to serious liver damage, a complication of the infection. ABOUT THE SPEAKER Dr. Bijal Parikh is the Medical Director of the Molecular Diagnostics Laboratory and Assistant Professor of Pathology & Immunology at Washington University in St. Louis, Missouri. He is the author of numerous publications with his clinical research centered on aspects of laboratory testing involving viral, immunologic, and molecular diagnostics, with a specific focus on the implementation of next-generation sequencing approaches. Recently, Dr. Parikh authored an article published in the Clinical Microbiology Newsletter titled Laboratory Strategies for Diagnosis and Monitoring of Hepatitis C Virus Infection.
Sarah Blach (CDA Foundation) summarises the latest analysis of global hepatitis C virus epidemiology and cascade of care by the Polaris Observatory HCV Collaborators.Read the full article:Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study
Sunil Solomon (Johns Hopkins University) discusses a study of a minimal monitoring approach for treating patients with hepatitis C virus infection.Read the full article:A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial
Dr. Rice is a virologist who is known for the development of effective treatments for hepatitis C virus (HCV). His work to generate a version of HCV that enabled the development of antiviral drugs capable of reducing HCV to undetectable levels, essentially curing chronic infection. For this breakthrough, Rice was awarded the 2020 Nobel Prize in Physiology/Medicine.Rice attended UC Davis for college and earned his graduate degree at Cal Tech, where he focused his research on RNA viruses. He deduced the genome of the virus that causes yellow fever and helped develop a vaccine. He also helped establish the flavivirus family which includes West Nile fever and Dengue fever. Rice then joined the faculty at the Washington University, where he shifted his focus to the development of a vaccine for hepatitis C. He generated a culturable version of the virus, allowing him to provide a description of the complete HCV genome and demonstrate the infectious nature of the virus. In 2001 Rice moved to Rockefeller University, where he discovered multiple proteins required for HCV entry into liver cells. In addition, he designed assays to test for drugs capable of blocking HCV replication, which led to new therapeutic agents for hepatitis C. The first of these drugs was approved in 2013 by the FDA.Rice was a recipient of the 2015 Robert Koch Prize and the 2016 Lasker-DeBakey Clinical Medical Research Award. He was an elected member of the American Association for the Advancement of Science in 2004 and the National Academy of Sciences in 2005.
In this episode, Nancy Reau, MD, discusses new viral hepatitis data from AASLD 2021, including:HBV treatment in pregnancyOutcomes following HBV treatment withdrawal Progress toward an HBV cureHCV implementation science and current status of the cascade of careHepatitis delta virus: understanding the clinical impactPhase III clinical trial updates for hepatitis delta virus, including data on bulevirtidePresenter: Nancy Reau, MDProfessor of Medicine Chief, Section of HepatologyAssociate Director, Solid Organ TransplantationRichard B. Capps Chair of HepatologyRush University Medical CenterChicago, IllinoisFollow along with the downloadable slideset at:https://bit.ly/3d6NQRVLink to full program:https://bit.ly/3lputrT
In this episode, Prof Ashley Brown, BSc, MD, FRCP, and Ahmed M. Elsharkawy, PhD, FRCP(UK), discuss key racial inequities of care that lead to undertreatment for migrant populations and other racial minorities globally with or at risk for hepatitis C.Topics include:HCV Burden and Care Disparities in Specific PopulationsGenotypes and Length of Infection in Ethnic MinoritiesPrimary Care Education and System-Related BarriersSolutions to Overcome Barriers to HCV CareFirst-hand Patient StoriesProf Ashley Brown, BSc, MD, FRCPProfessor of Practice, Viral HepatitisDivision of Metabolism, Digestion and ReproductionImperial College LondonConsultant HepatologistLiver & Antiviral UnitImperial College Healthcare NHS TrustLondon, United KingdomAhmed M. Elsharkawy, PhD, FRCP(UK)Consultant Hepatologist and Honorary Senior LecturerLiver Unit and Biomedical Research CentreUniversity Hospitals BirminghamUniversity of BirminghamBirmingham, United KingdomContent based on a CME program supported by educational grants provided by AbbVie; Gilead Sciences, Inc.; and Janssen Therapeutics, Division of Janssen Products, LP To follow along, download the slides at:https://bit.ly/36UDLViLink to full program:https://bit.ly/3kKIb9a
In this episode, Stefan Zeuzem, MD, discusses exciting new data on viral hepatitis reported at the virtual EASL 2021, including new findings on treatment of HDV, treatment of HBV and HCV in children, linking patients to care, and new molecules being investigated for HBV cure.Stefan Zeuzem, MDProfessor of MedicineChief, Department of Medicine IJW Goethe University Hospital Frankfurt, GermanyContent based on a CME program supported by educational grants provided by AbbVie, Antios Therapeutics, and Gilead Sciences, Inc.To follow along, download the slides at:https://bit.ly/3rl8AeSLink to full program:https://bit.ly/3ky46QK
In this podcast, Paul Y. Kwo, MD talks about his research that investigated different strategies for treating chronic hepatitis C virus (HCV), as well as why he believes the diagnosis of HVC and treatment of patients with HCV need to be decentralized.
We speak to Dr Máirín Ryan, HIQA's Deputy CEO.
This is a podcast article summary of "Survey of Clinician Opinions on Kidney Transplantation from Hepatitis-C Virus-Positive Donors: Identifying and Overcoming Barriers" by Krista L. Lentine and David A. Axelrod.
In this episode, Dr. Terrault discusses results from key viral hepatitis studies reported at the American Association for the Study of LiverDiseases (AASLD) 2020 annual conference, The Liver Meeting Digital Experience, including new findings on HBV treatment and management, hepatocellular carcinoma risk, and emerging approaches to HCV care in underserved populations.Presenter:Norah Terrault, MD, MPHProfessor of MedicineChief of Gastrointestinal and Liver DiseasesUniversity of Southern CaliforniaLos Angeles, CaliforniaContent based on a CME program supported by an independent educational grant from Gilead Sciences, Inc.Link to full program: https://bit.ly/37bBrce
In this podcast, Vincent Lo Re, MD, MSCE, talks about the barriers to hepatitis C virus direct-acting antiviral therapy and how they can be overcome, as well as the research question he hopes to answer by the end of his carer. More at www.consultant360.com
In this podcast, Vincent Lo Re, MD, talks about the current knowledge gaps around hepatitis C virus screening, as well as how health care providers can implement better screening protocols in their practice. More at www.Consultant360.com
In this podcast, Vincent Lo Re, MD, MSCE, talks about the common pitfalls in hepatitis C virus management, as well as his best practices for reducing the risk of reinfection. More at www.Consultan360.com
Das ging schnell: Acht Jahre nach ihrer bahnbrechenden Arbeit erhalten Emmanuelle Charpentier und Jennifer Doudna für die Entdeckung der Genschere «CRISPR-Cas9» den Nobelpreis für Chemie. Die Technik ist heute aus den Labors nicht mehr wegzudenken und die Medizin sieht grosses Potential für neue Medikamente und Therapien. Ausserdem: Nobelpreis für Medizin für die Entdeckung des Hepatitis C Virus. Wir beleuchten die Situation in der Schweiz. Und: Nobelpreis für Physik für die Entdeckung von Schwarzen Löchern. Wir versuchen zu klären, wie es in einem drin aussieht.
Americans Harvey Alter and Charles Rice with Briton Michael Houghton won the Nobel Prize in Medicine for discovering the Hepatitis C virus. This has an Indian dimension. The Nobel Prize for Chemistry was shared, for the first time, by two women — Emmanuelle Charpentier of France, and American Jennifer Doudna for inventing a ‘scissors’ which allows scientists to ‘cut-paste’ inside a genetic sequence. In episode 588 of Cut The Clutter, Shekhar Gupta simplified the intricate science of both.
Autor: Floto, Christian Sendung: Sprechstunde Hören bis: 19.01.2038 04:14
De Nobelprijs voor de geneeskunde gaat dit jaar naar de ontdekking van het Hepatitis-C-virus. Dat virus kan een chronische ontsteking van de lever veroorzaken. En die ontsteking kan vervolgens leiden tot leverkanker en levercirrose. Volgens het Nobelprijscomité heeft het werk van de drie Nobel-laureaten miljoenen levens gered. Roel Coutinho is emeritus hoogleraar epidemiologie en infectieziektenbestrijding aan de Universiteiten van Amsterdam en Utrecht en hij coördineert een hepatitis C-behandelingsprogramma in Kameroen. Hij vindt de prijs zeer terecht.
Themen der Sendung: Trumps Pressesprecherin McEnany ebenfalls positiv auf das Coronavirus getestet, Diskussion über Corona-Auflagen in Deutschland, Tragen einer Maske wird im Bundestag zur Pflicht, Frankreich verzeichnet ansteigende Corona-Infektionszahlen und schließt Bars und Cafés in Paris, Parteien diskutieren Spahns Vorschlag für eine Pflegereform, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
Themen der Sendung: Trumps Pressesprecherin McEnany ebenfalls positiv auf das Coronavirus getestet, Diskussion über Corona-Auflagen in Deutschland, Tragen einer Maske wird im Bundestag zur Pflicht, Frankreich verzeichnet ansteigende Corona-Infektionszahlen und schließt Bars und Cafés in Paris, Parteien diskutieren Spahns Vorschlag für eine Pflegereform, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
Themen der Sendung: Trumps Pressesprecherin McEnany ebenfalls positiv auf das Coronavirus getestet, Diskussion über Corona-Auflagen in Deutschland, Tragen einer Maske wird im Bundestag zur Pflicht, Frankreich verzeichnet ansteigende Corona-Infektionszahlen und schließt Bars und Cafés in Paris, Parteien diskutieren Spahns Vorschlag für eine Pflegereform, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
Themen der Sendung: Trumps Pressesprecherin McEnany ebenfalls positiv auf das Coronavirus getestet, Diskussion über Corona-Auflagen in Deutschland, Tragen einer Maske wird im Bundestag zur Pflicht, Frankreich verzeichnet ansteigende Corona-Infektionszahlen und schließt Bars und Cafés in Paris, Parteien diskutieren Spahns Vorschlag für eine Pflegereform, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
Themen der Sendung: Trumps Pressesprecherin McEnany ebenfalls positiv auf das Coronavirus getestet, Diskussion über Corona-Auflagen in Deutschland, Tragen einer Maske wird im Bundestag zur Pflicht, Frankreich verzeichnet ansteigende Corona-Infektionszahlen und schließt Bars und Cafés in Paris, Parteien diskutieren Spahns Vorschlag für eine Pflegereform, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
Themen der Sendung: Trumps Pressesprecherin McEnany ebenfalls positiv auf das Coronavirus getestet, Diskussion über Corona-Auflagen in Deutschland, Tragen einer Maske wird im Bundestag zur Pflicht, Frankreich verzeichnet ansteigende Corona-Infektionszahlen und schließt Bars und Cafés in Paris, Parteien diskutieren Spahns Vorschlag für eine Pflegereform, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
Themen der Sendung: Trump verlässt Klinik nach Covid 19-Behandlung, Diskussion über Corona-Auflagen in Deutschland, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
Ralf Bartenschlager leitet das Zentrum für Infektiologie an der Uni Heidelberg. Er hat viel zum Hepatitis-C-Virus geforscht und findet es eine gute Entscheidung, den Entdeckern den Nobelpreis für Medizin zu verleihen.
Themen der Sendung: Trump verlässt Klinik nach Covid 19-Behandlung, Diskussion über Corona-Auflagen in Deutschland, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
Themen der Sendung: Trump verlässt Klinik nach Covid 19-Behandlung, Diskussion über Corona-Auflagen in Deutschland, Ermittlungen nach Angriff auf jüdischen Studenten vor Synagoge in Hamburg, Große Koalition berät über Anschaffung von bewaffneten Drohnen für Bundeswehr, Nobelpreis für Medizin geht an Entdecker des Hepatitis-C-Virus, Das Wetter
De Nobelprijs voor Fysiologie of Geneeskunde is maandag toegekend aan drie ontdekkers van het hepatitis C-virus. De ontdekking van het virus, eind jaren 80, heeft geleid tot veilige bloedtransfusies en sinds kort ook behandeling die het virus kan opruimen. Toch overlijden er jaarlijks nog 400.000 mensen aan een infectie door hepatitis C. Medisch redacteur Niki Korteweg praat je bij over de ontdekking van het virus.Presentatie: Lucas Brouwers, Niki KortewegProductie: Kim Kabbedijk@lucasbrouwers // @nikikortewegWord lid van onze Facebookgroep!https://www.facebook.com/groups/nrconbehaardeapenWij zijn genomineerd voor een Dutch podcast award. Is Onbehaarde Apen jouw favoriete podcast? Breng dan hier je stem uit:https://podcastawards.nl/stem#tech-wetenschap
Millionen Menschen verdanken ihnen ihr Leben – oder zumindest ein längeres Leben. Harvey J. Alter, Michael Houghton und Charles M. Rice haben das Hepatitis-C-Virus entdeckt. Zumindest haben sie maßgeblich zur Entdeckung des Virus beigetragen, schreibt das Institut in einer Erklärung. Das Virus sei ein "globales Gesundheitsproblem". Nach WHO-Angaben sterben jährlich weltweit fast 400.000 Menschen infolge einer Hepatitis-C-Infektion, 71 Millionen Menschen sind chronisch infiziert. Dank der drei Forscher können die vom Virus verursachten Erkrankungen inzwischen geheilt werden. Heute gebe es hochempfindliche Bluttests zum Nachweis des Erregers, schreibt das Nobelkomitee in seiner Begründung für die Preisvergabe. Dadurch kämen Infektionen nach Bluttransfusionen in vielen Ländern der Welt praktisch nicht mehr vor. Ole Pflüger spricht mit Wissensredakteur Jakob Simmank darüber, wieso Hepatitis C so gefährlich ist und wieso die Entdeckung des Virus so wichtig war. Außerdem geht es im Nachrichtenpodcast um die heutige Sitzung des Corona-Kabinetts. Was noch? Ein Dino stirbt aus. Moderation: Ole Pflüger Fragen, Kritik, Anregungen? Sie erreichen uns unter wasjetzt@zeit.de. Alle Folgen finden Sie hier.
A study in the February issue of Gastroenterology examined the safety and efficacy of an interferon-free, ribavirin-free regimen of direct-acting antivirals in patients with chronic HCV infection. Dr. Kuemmerle speaks to Dr. Gregory T. Everson.