Podcast appearances and mentions of meta analysis

Jonny and Phil review the South Coast GT weekend: venue praise, the 1,000‑point pack, mission choices, and how the tables and timing worked. Phil also announces the details of English Open (Warfare, 14–15 November, 1066 points, thematic lists) and explains booking details and incentives. The episode covers competitive meta takeaways — Japan's strong showing, the value of veteran troops and dice count, the role of armour and flamethrowers, and tips on listbuilding — and finishes with results and awards, including the top placings and community shoutouts. Links:

The March 2026 ACC/AHA Guideline on the Management of Dyslipidemia made a major pivot regarding Lipoprotein(a) by establishing a formal recommendation for universal screening in adults. This 2026 guideline, published in the Journal of the American College of Cardiology, issued a Class 1 recommendation stating that every adult should have their Lp(a) measured at least once in their lifetime. Because Lp(a) levels are genetically determined and remain highly stable throughout a person's life, a single lifetime check is sufficient for the vast majority of the population to establish their baseline risk. Well, that's great for Family medicine or internal medicine, but how does that affect us in women's health? Well, it's complicated: lipoprotein(a) has been associated with an increased risk of VTE and has also been associated, in some studies, with FGR, preeclampsia, and preterm birth! So, can these patients receive oral contraceptives? What about Perioperative and postop care? Do these patients require anticoagulation? What about pregnancy- is LDA recommended here? And lastly, what about TXA use in patients with HMB? This podcast topic comes from one of our podcast family members who is an OBGYN military personnel caring for our wonderful troops overseas. Listen in for details!16% OFF TONA ACTIVE WEAR PROMO: https://tonaactive.com/discount/CHAPANOSPINOBG1. Ezzat, D., Lopez, D. M., Claggett, B. L., Li, L., Mohammadnia, N., Schuermans, A., Hemeryck, J., Chang, A., Murillo, S., O'Donoghue, M. L., Bikdeli, B., Yu, Z., Natarajan, P., Patel, A. P., Pabon, M. A., & Honigberg, M. C. (2026). Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men. European Heart Journal, ehag252. https://doi.org/10.1093/eurheartj/ehag2522.ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Dyslipidemia Writing Committee. (2026). 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia. Circulation, 153, e1155–e1300. https://doi.org/10.1161/CIR.00000000000014233. CDC MEC 4. Prevention of Venous Thromboembolism in Gynecologic Surgery: ACOG Practice Bulletin, Number 232. Obstetrics and Gynecology. 2021. Committee on Practice Bulletins—Gynecology5. Sofi F, Marcucci R, Abbate R, Gensini GF, Prisco D.Lipoprotein(a) as a Risk Factor for Venous Thromboembolism: A Systematic Review and Meta-Analysis of the Literature.Seminars in Thrombosis and Hemostasis. 2017. Dentali F, Gessi V, Marcucci R, et al. Lipoprotein (A) and Venous Thromboembolism in Adults: The American Journal of Medicine. 2007.

This is my personal favorite topic, but probably your least favorite: strength training.  Before you run away, hear me out! Because whether you’re bed-bound, housebound, or just convinced your body can’t handle it right now, this episode is for you. I’m breaking down exactly WHY resistance and strength training isn’t just helpful for vestibular disorders—it’s essential.  You Have to Move Your Body to Manage Your Dizziness From the dizzy-anxious-dizzy cycle to blood sugar regulation to better sleep to reduced inflammation, strength training touches virtually every struggle vestibular warriors face. I’m not letting anyone off the hook, but I am meeting you exactly where you are. Starting with 3 minutes? That counts.  Walking to the mailbox and back? That counts too.  Because the goal here is progress, not perfection. And you know I have the science to back every single word of it! In this episode, we'll dig into: Why strength training is non-negotiable for vestibular disorder management How exercise helps break the dizzy-anxious-dizzy cycle “In the moment” vs. “hangover” dizziness and how to adjust your approach Why EDS, HSD, or MCAS makes building muscle even more critical The truth about the fear of getting “bulky” How to start exercising when you’re bedbound or couch-bound What physical activity guidelines actually say, and where most people fall short How functional movements like the deadlift directly support vestibular patients How Vestibular Group Fit makes strength and resistance training accessible Whether you start with 3 minutes or 30, the most important thing is that you start. Because your vestibular system, your mood, your balance, and your future self are all counting on it. Links Mentioned: Vestibular Group Fit (code GROUNDED at checkout for 15% off!): https://thevertigodoctor.com/vestibular-group-fit Free Resources: ⁠The 4 Steps to Managing Vestibular Migraine: https://thevertigodoctor.myflodesk.com/cb5js0y78n ⁠The PPPD Management Masterclass⁠: https://thevertigodoctor.myflodesk.com/new-pppd ⁠What your Partner Should Know About Living with Dizziness⁠: https://thevertigodoctor.myflodesk.com/partnership ⁠The FREE Mini VGFit Workout⁠: https://thevertigodoctor.myflodesk.com/minifit ⁠The FREE POTS – safe Workouts⁠: https://thevertigodoctor.myflodesk.com/pots Connect with Dr. Madison (@TheVertigoDoctor): https://instagram.com/thevertigodoctor Work with Dr. Madison: For 1:1 Vestibular Rehabilitation Therapy, email madison@thevertigodoctor.com Otherwise, I'll see ya in Vestibular Group Fit! Connect with Dr. Jenna (@dizzy.rehab.therapist): https://www.instagram.com/dizzy.rehab.therapist/ Learn about the Oak Method: http://thevertigodoctor.com/why-vestibular-group-fit Citations: Adriano Oliveira, Andressa Fidalgo, Paulo Farinatti, Walace Monteiro,Effects of high-intensity interval and continuous moderate aerobic training on fitness and health markers of older adults: A systematic review and meta-analysis,Archives of Gerontology and Geriatrics,Volume 124,2024,105451,ISSN 0167-4943,https://doi.org/10.1016/j.archger.2024.105451.(https://www.sciencedirect.com/science/article/pii/S0167494324001274) Yu Y, Wang J, Xu J. Optimal dose and type of exercise to improve cognitive function in patients with mild cognitive impairment: a systematic review and network meta-analysis of RCTs. Front Psychiatry. 2024 Sep 12;15:1436499. doi: 10.3389/fpsyt.2024.1436499. PMID: 39328348; PMCID: PMC11424528. Zhang Y, Zhou M, Yin Z, Zhuang W, Wang Y. Relationship between physical activities and mental health in older people: a bibliometric analysis. Front Psychiatry. 2024 Oct 21;15:1424745. doi: 10.3389/fpsyt.2024.1424745. PMID: 39497901; PMCID: PMC11532734. Garcia Meneguci, C. A., Meneguci, J., Sasaki, J. E., Tribess, S., & Júnior, J. S. V. (2021). Physical activity, sedentary behavior and functionality in older adults: A cross-sectional path analysis. PloS one, 16(1), e0246275. https://doi.org/10.1371/journal.pone.0246275 Mennitti C, Farina G, Imperatore A, De Fonzo G, Gentile A, La Civita E, Carbone G, De Simone RR, Di Iorio MR, Tinto N, Frisso G, D’Argenio V, Lombardo B, Terracciano D, Crescioli C, Scudiero O. How Does Physical Activity Modulate Hormone Responses? Biomolecules. 2024 Nov 7;14(11):1418. doi: 10.3390/biom14111418. PMID: 39595594; PMCID: PMC11591795. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010 Jun 3;411(11-12):785-93. doi: 10.1016/j.cca.2010.02.069. Epub 2010 Feb 25. PMID: 20188719; PMCID: PMC3629815.  Chastin, S.F.M., Abaraogu, U., Bourgois, J.G. et al. Effects of Regular Physical Activity on the Immune System, Vaccination and Risk of Community-Acquired Infectious Disease in the General Population: Systematic Review and Meta-Analysis. Sports Med 51, 1673–1686 (2021). https://doi.org/10.1007/s40279-021-01466-1 Hoffman GJ, Malani PN, Solway E, Kirch M, Singer DC, Kullgren JT. Changes in activity levels, physical functioning, and fall risk during the COVID-19 pandemic. J Am Geriatr Soc. 2022 Jan;70(1):49-59. doi: 10.1111/jgs.17477. Epub 2021 Sep 24. PMID: 34536288. Rey-Lopez JP, Rimm EB, Tabung FK, Giovannucci EL. Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults. Circulation. 2022 Aug 16;146(7):523-534. doi: 10.1161/CIRCULATIONAHA.121.058162. Epub 2022 Jul 25. PMID: 35876019; PMCID: PMC9378548. Hupin D, Roche F, Gremeaux V, Chatard JC, Oriol M, Gaspoz JM, Barthélémy JC, Edouard P. Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta-analysis. Br J Sports Med. 2015 Oct;49(19):1262-7. doi: 10.1136/bjsports-2014-094306. Epub 2015 Aug 3. PMID: 26238869. Chandrasekaran B, Ganesan TB. Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review. Scott Med J. 2021 Feb;66(1):3-10. doi: 10.1177/0036933020946336. Epub 2020 Jul 27. PMID: 32718266; PMCID: PMC8685753. Izquierdo M, Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, García-Hermoso A, Gutiérrez-Robledo LM, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Ramírez-Vélez R, Rodriguez-Mañas L, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. J Nutr Health Aging. 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961; PMCID: PMC12369211. Bunnell E, Stratton MT. The Impact of Functional Training on Balance and Vestibular Function: A Narrative Review. J Funct Morphol Kinesiol. 2024 Dec 3;9(4):251. doi: 10.3390/jfmk9040251. PMID: 39728235; PMCID: PMC11679947. Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985 Mar-Apr;100(2):126-31. PMID: 3920711; PMCID: PMC1424733. Warner A, Vanicek N, Benson A, Myers T, Abt G. Agreement and relationship between measures of absolute and relative intensity during walking: A systematic review with meta-regression. PLoS One. 2022 Nov 3;17(11):e0277031. doi: 10.1371/journal.pone.0277031. PMID: 36327341; PMCID: PMC9632890. “Metabolic Equivalent (MET): Pick the Best Exercise for Longevity.” Whyiexercise.com, www.whyiexercise.com/metabolic-equivalent.html. Love what you heard?Consider leaving a review on your favorite podcast platform to help us reach more vestibular warriors like you! This podcast is for informational purposes only and may not be the best fit for you and your personal situation. It shall not be construed as medical advice. The information and education provided here is not intended or implied to supplement or replace professional medical treatment, advice, and/or diagnosis. Always check with your own physician or medical professional before trying or implementing any information read here. ————————————— strength and resistance training, exercises for vestibular disorders, living with vestibular migraine, guidelines of physical activity, anxiety and depression, chronic dizziness, couch bound, bed bound, dizzy-anxious-dizzy cycle, physical therapist

Join Dr. Clancy and his guests Dr. Endres and Lori Winborn as they delve into the world of ultra processed foods, exploring their origins, popularity, potential harms, and practical guidance for adopting a healthier diet. Episode Transcript CE Credit Available Host: Gerard Clancy, MD Senior Associate Dean for External Affairs Professor of Psychiatry and Emergency Medicine University of Iowa Carver College of Medicine Guests: Jill Endres, MD, MS, FAAFP Clinical Professor of Family and Community Medicine University of Iowa Carver College of Medicine Lori Winborn, MPH, RDN, LD Dietician University of Iowa Health Care Financial Disclosures:  Dr. Gerard Clancy, his guests, and Rounding@IOWA planning committee members have disclosed no relevant financial relationships. Nurse: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this activity for a maximum of 0.75 ANCC contact hour. Physician: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Other Health Care Providers: A certificate of completion will be available after successful completion of the course. (It is the responsibility of licensees to determine if this continuing education activity meets the requirements of their professional licensure board.) References/Resources:  Grinshpan LS, Eilat-Adar S, Ivancovsky-Wajcman D, Kariv R, Gillon-Keren M, Zelber-Sagi S. Ultra-processed food consumption and non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance: A systematic review. JHEP Rep. 2023 Nov 17;6(1):100964. doi: 10.1016/j.jhepr.2023.100964. PMID: 38234408; PMCID: PMC10792654. Vitale M, Constabile G.. et al. Ultra-Processed Foods and Human Health: A Systemic Review and Meta-Analysis of Prospective Cohort Studies. Adv Nutr. 202444 Jan;15(1):100121. doi: 10.1016/i.advnut.2023.09.009. Epub 2023 Dec 18. PMID: 38245358; PMCID: PMC10831891  

A headline like “weight loss drugs may reduce breast cancer risk” grabs attention fast, but the real story lives in the fine print. We take you through a new Penn Medicine study that observed lower breast cancer rates among women with overweight or obesity who used GLP-1 medications, then we translate what that finding actually means in plain language. Observational data can reveal a signal worth studying, but it cannot prove the medication caused the outcome, and that distinction matters for your decisions and your expectations. We also zoom out to the bigger why: obesity is not just about body size. Fat tissue is biologically active, shaping chronic inflammation, estrogen exposure after menopause, insulin resistance, and even how well the immune system spots abnormal cells. Those pathways help explain why obesity is linked to many cancers, including postmenopausal breast cancer, and why researchers are curious whether effective obesity treatment could shift risk over time. Then we get practical. We review what stronger evidence from randomized controlled trials says so far: GLP-1 drugs like Ozempic, Wegovy, Mounjaro, and Zepbound do not appear to increase breast cancer risk in the available trial data, even though most trials were not designed to study cancer outcomes for many years. We also discuss why newer studies seem most suggestive for hormone receptor positive breast cancer, along with the leading theories: weight loss itself, improved metabolic health and insulin signaling, reduced inflammation, and the still-unclear possibility of direct GLP-1 effects in cancer biology. If you like evidence-based medicine with real-world context (and a little Philly-life banter), subscribe, share this episode with a friend, and leave a review so more people can find the show. What question do you want answered next about GLP-1s, obesity treatment, or cancer risk?ReferencesRisk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists : A Systematic Review and Meta-Analysis. Ko A, Chang YC, Bahar F, et al. Annals of Internal Medicine. 2025;. doi:10.7326/ANNALS-25-02237.Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-Analysis. Piccoli GF, Mesquita LA, Stein C, et al. The Journal of Clinical Endocrinology and Metabolism. 2021;106(3):912-921. doi:10.1210/clinem/dgaa891.Glucagon-Like Peptide 1 Receptor Agonists and Cancer Risk: The Good, the Bad and the Unknown. Mannucci E, Dicembrini I. Nature Reviews. Clinical Oncology. 2026;23(6):459-470. doi:10.1038/s41571-026-01135-0.GLP-1 Agonists Are Associated With a Significant Reduction in Breast Cancer Incidence in Women. McDonald ES, Gillis LB, Gabriel P, et al. JCO Oncology Practice. 2026;:101200OP2600485. doi:10.1200/OP-26-00485.GLP-1 therapy and hormone receptor–positive breast cancer risk and survival: A real-world analysis.. Shah Z, Hundal J, Afridi S, et al. Journal of Clinical Oncology. 2026;44(Suppl 16):10548. doi:10.1200/JCO.2026.44.16_suppl.10548.Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer. Tatum KL, Dahman B, Stevenson A, et al. JAMA Network Open. 2026;9(5):e2612133. doi:10.1001/jamanetworkopen.2026.12133.Association of Glucagon-Like Peptide-1 Receptor Agonists With Risk of Cancers-Evidence From a Drug Target Mendelian Randomization and Clinical Trials. Sun Y, Liu Y, Dian Y, et al. International Journal of Surgery (London, England). 2024;110(8):4688-4694. doi:10.1097/JS9.0000000000001514.GLP-1 receptor agonists and breast cancer risk in type 2 diabetes.. Guo Cheng and Amanda Ward. Journal of Clinical Oncology. 2025;43(Suppl 16):10557. doi:10.1200/JCO.2025.43.16_suppl.10557.Glucagon-Like Peptide-1 Analogues and Risk of Breast Cancer in Women With Type 2 Diabetes: Population Based Cohort Study Using the UK Clinical Practice Research Datalink. Hicks BM, Yin H, Yu OH, et al. BMJ (Clinical Research Ed.). 2016;355:i5340. doi:10.1136/bmj.i5340.GLP-1 Receptor Agonists and Cancer: Current Clinical Evidence and Translational Opportunities for Preclinical Research. Valencia-Rincón E, Rai R, Chandra V, Wellberg EA. The Journal of Clinical Investigation. 2025;135(21):e194743. doi:10.1172/JCI194743.Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.Support the showProduction and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RNArtwork Rebrand and Avatars:Vantage Design Works (Vanessa Jones) Website: https://www.vantagedesignworks.com/Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qrOriginal Artwork Concept: Olivia Pawlowski

Un nouvel épisode du Pharmascope est disponible! Dans ce 178e épisode, Nicolas, Olivier et Amélie tentent de pondre des réponses un tant soi peu intelligentes à vos excellentes questions. Nous discutons d'ajustement de lévothyroxine, du suivi des IECA/ARA, du rôle de la cariprazine et de l'impact des inhibiteurs du SGLT-2 sur le magnésium.   Les objectifs pour cet épisode sont les suivants: Discuter des modalités d'ajustement de la lévothyroxine et de la déprescription potentielle de celle-ci Discuter des suivis de laboratoire suivant l'initiation d'un ARA ou d'un IECA Discuter des évidences portant sur l'utilisation de la cariprazine Discuter de l'impact des  inhibiteurs du SGLT-2 sur le magnésium Ressources pertinentes en lien avec l'épisode Jonklaas J, et coll; American Thyroid Association Task Force on Thyroid Hormone Replacement. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014 Dec;24(12):1670-751. Van Uytfanghe K, et coll. Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status. Thyroid. 2023 Sep;33(9):1013-1028. Ravensberg J, et coll. Discontinuation of Levothyroxine in Adults Aged 60 Years or Older. JAMA. 2026 Apr 6;335(17):1491–8. RPE de néphrologie de l'APES. Place des IECA et des ARA dans le traitement de la maladie rénale chronique. Septembre 2025. Bhandari S, et coll; STOP ACEi Trial Investigators. Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease. N Engl J Med. 2022 Dec 1;387(22):2021-2032. Clase CM, et coll. Acute change in glomerular filtration rate with inhibition of the renin-angiotensin system does not predict subsequent renal and cardiovascular outcomes. Kidney Int 2017;91:683-90. Garlo KG, et coll. Association of changes in creatinine and potassium levels after initiation of renin angiotensin aldosterone system inhibitors with emergency department visits, hospitalizations, and mortality in individuals with chronic kidney disease. JAMA Netw Open 2018;1:e183874. Monographie de produit, Abbvie. VRAYLAR (cariprazine). Canada, 6 mars 2024. Barabassy A, et coll. Transdiagnostic Efficacy of Cariprazine: A Systematic Review and Meta-Analysis of Efficacy Across Ten Symptom Domains. Pharmaceuticals (Basel). 2025 Jul 2;18(7):995. Németh G, et coll. Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial. Lancet. 2017 Mar 18;389(10074):1103-1113. Fava M, et coll. Efficacy of adjunctive low-dose cariprazine in major depressive disorder: a randomized, double-blind, placebo-controlled trial. Int Clin Psychopharmacol. 2018 Nov;33(6):312-321. Durgam S, et coll. Efficacy and safety of adjunctive cariprazine in inadequate responders to antidepressants: a randomized, double-blind, placebo-controlled study in adult patients with major depressive disorder. J Clin Psychiatry. 2016 Mar;77(3):371-8. Barabassy A, Csehi R, Dombi ZB, Szatmári B, Brevig T, Németh G. Transdiagnostic Efficacy of Cariprazine: A Systematic Review and Meta-Analysis of Efficacy Across Ten Symptom Domains. Pharmaceuticals (Basel). 2025 Jul 2;18(7):995. Zhang J, et coll. Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Serum Electrolyte Levels in Patients with Type 2 Diabetes: A Pairwise and Network Meta-Analysis of Randomized Controlled Trials. Kidney360. 2022 Jan 19;3(3):477-487. Toto RD, et coll. Correction of hypomagnesemia by dapagliflozin in patients with type 2 diabetes: A post hoc analysis of 10 randomized, placebo-controlled trials. J Diabetes Complications. 2019 Oct;33(10):107402.

Content warning: childhood abuse, childhood sexual abuse, sexual assault, rape, abduction, missing persons, gun violence, murder, and mental illness.Amber Rodgers is a survivor, business professional, and creative from Texas. As early as she can remember, her life was filled with chaos. By the time she was fourteen, she was a multi-crime survivor, and by 19 she would serve as a witness in her best friend's murder trial. Amber moved forward by cultivating a successful career and loving family, until her past trauma instigated a cascading effect in her mental health and relationships. Although Amber has shared portions of her story at-large, it took her decades and a life-altering mental health journey to realize the deep impact her teen years had had on her. The Broken Cycle Media team is deeply appreciative of Amber's transparency, rawness, and advocacy. These episodes are dedicated in loving memory of Kytrina Marie Locascio.Sources: -Centers for Disease Control and Prevention. “About Adverse Childhood Experiences.” CDC, U.S. Department of Health and Human Services, 2025, https://www.cdc.gov/violenceprevention/aces/. -Centers for Disease Control and Prevention. “Adverse Childhood Experiences (ACEs).” CDC Vital Signs, U.S. Department of Health and Human Services, https://www.cdc.gov/vitalsigns/aces/index.html. -Centers for Disease Control and Prevention. “Psychosocial Factors and Health Equity.” CDC, U.S. Department of Health and Human Services, https://www.cdc.gov/dhdsp/health_equity/psychosocial.htm. -Felitti, Vincent J., et al. “Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study.” American Journal of Preventive Medicine, vol. 14, no. 4, 1998, pp. 245–258.-Hughes, Karen, et al. “The Effect of Multiple Adverse Childhood Experiences on Health: A Systematic Review and Meta-Analysis.” The Lancet Public Health, vol. 2, no. 8, 2017, pp. e356–e366. doi:10.1016/S2468-2667(17)30118-4.-McKay, Matthew T., Laura Kilmartin, Aisling Meagher, Mary Cannon, Colm Healy, and Mary C. Clarke. “A Revised and Extended Systematic Review and Meta-Analysis of the Relationship between Childhood Adversity and Adult Psychiatric Disorder.” Journal of Psychiatric Research, vol. 156, 2022, pp. 159–174. PubMed, https://pubmed.ncbi.nlm.nih.gov/36274532/. -Swedo, Elizabeth A., et al. “Prevalence of Adverse Childhood Experiences Among U.S. Adults—Behavioral Risk Factor Surveillance System, 2011–2020.” Morbidity and Mortality Weekly Report, vol. 72, no. 26, 2023, pp. 707–715, https://www.cdc.gov/mmwr/volumes/72/wr/mm7226a2.htm. -Zhang, Y., et al. “Cumulative Adverse Childhood Experiences and Risk of Mental Disorders: A Systematic Review and Meta-Analysis.” Acta Psychiatrica Scandinavica, 2026, https://www.sciencedirect.com/science/article/pii/S0001691826007559. Accessed 2 June 2026.For additional resources and a list of non-profit organizations that can help, please visit http://www.somethingwaswrong.com/resources*Thank you again to Rula and Quince for sponsoring this episode. *Remember, Rula patients typically pay $15 per session when using insurance. Connect with quality therapists and mental health experts who specialize in you at https://www.rula.com/wcn #rulapod *And don't forget to elevate your summer wardrobe, go to quince.com/wcn for free shipping on your order and 365-day returns, now available in Canada too.

Most of us instinctively understand that we feel better when we spend time in nature. But our relationship to the natural world is perhaps even more powerful than we appreciate. On today's episode, host Rachel is joined by Emily Long—licensed clinical social worker, certified nature-informed therapist, and yoga teacher. Emily shares research on the therapeutic benefits of building a more mindful relationship with nature, whether that means spending time outdoors, inviting natural elements indoors, even simply viewing nature through a window. Emily also reminds us how nature is deeply embedded in the yoga tradition.  From stress reduction and improved cognitive function to increased resilience and emotional regulation, this conversation highlights the many ways reconnecting with nature can support our well-being, and how our practice could be the perfect time and place to do so. "What we care for cares for us." — Emily Long. — What You'll Learn: • How yoga already reflects our connection to nature [3:08] • Stereotypes can discourage people from developing a relationship with nature [9:19] • Research: nature and our health [12:56] • "Softly fascinating stimuli" and the nervous system [16:12] • Reaping the benefits whether we enjoy nature or not [20:40] • Nature encourages social and community connection [23:44] • Practical ways to invite nature into indoor spaces [26:35] • Taking opportunities to go outside [29:02] • Natural imagery, honoring seasonal rhythms [30:59] • Ahimsa, reciprocity, and caring for the environment [37:33] — Links Mentioned: Watch this episode on YouTube Relevant research: Soga, M., & Gaston, K. J. (2025). Health benefits of viewing nature through windows: A meta-analysis. Bioscience, 75(8), 628–636. https://doi.org/10.1093/biosci/biaf089 Stevenson, M. P., Schilhab, T., & Bentsen, P. (2018). Attention Restoration Theory II: a systematic review to clarify attention processes affected by exposure to natural environments. Journal of toxicology and environmental health. Part B, Critical reviews, 21(4), 227–268. https://doi.org/10.1080/10937404.2018.1505571 Bettmann, J. E., Speelman, E., Blumenthal, E., Couch, S., & McArthur, T. (2024). How Does Nature Exposure Affect Adults With Symptoms of Mental Illness? A Meta-Analysis. International journal of mental health nursing, 33(6), 1889–1907. https://doi.org/10.1111/inm.13400 Ulrich R. S. (1984). View through a window may influence recovery from surgery. Science (New York, N.Y.), 224(4647), 420–421. https://doi.org/10.1126/science.6143402  Connect with Emily Long: Instagram | Yoga With Emily | Emily Long LCSW — Learn More: Find the full show notes at YogaMedicine.com/podcast-168. Learn more about insider tips, online classes or information on our teacher trainings at YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts or wherever you listen to podcasts. 

Think energy, digestion, and weight. In this episode, Nurse Doza breaks down berberine — the metabolism-supporting supplement that helps regulate blood sugar, support a healthy insulin response, and improve cholesterol (LDL, HDL, total). Discover why MSW Nutrition's Berberine Plus is 5x more absorbable in the gut, how to dose it morning and night, and why it works at the level of your gut microbiome. The berberine supplement your metabolism has been waiting for. Featured Partner: MSW Nutrition — Berberine Plus MSW Nutrition's Berberine Plus delivers dihydroberberine (DHB) — the bioactive, highly absorbable form of berberine sourced from Berberis aristata — so you get berberine's full metabolic benefits at a fraction of the dose, without the gut upset that comes from mega-dosing standard berberine. That enhanced absorption is exactly why it's the berberine supplement Nurse Doza reaches for to support blood sugar, digestion, and weight — as discussed in this episode.

The 21-day habit rule is a myth — and the truth is so much more encouraging. Today we're digging into what the research actually says about how long it takes to build a habit that lasts, and why the real timeline should make you feel better, not worse. Plus, we'll chat about how I kicked a very long and intense Diet Coke habit and also 8 tips to make healthy habits easier to form and keep! LET'S TALK THE WALK! Join here for support, motivation and fun! Wellness While Walking Facebook page Walking to Wellness Together Facebook GROUP Wellness While Walking on Instagram Wellness While Walking on Threads Wellness While Walking on Twitter Wellness While Walking website for show notes and other information wellnesswhilewalking@gmail.com RESOURCES AND SOURCES (some links may be affiliate links) Time to Form a Habit: A Systematic Review and Meta-Analysis of Health Behaviour Habit Formation and Its Determinants, nih.gov  Kicking A Bad Habit/Reducing Reliance on an Addiction Wellness While Walking Ep. 39: My Coffee Journey: Flavored, Decaf, Rituals + a Wrong Turn Wellness While Walking Ep. 53: Goals Deep Dive: SMART, Big Hairy Audacious + Otherwise I Was Powerless Over Diet Coke, nyt.com Abby Ellin's website Replica of a Dr Pepper Clock – 10, 2 and 4 New Brain Imaging Study Provides Support For Notion of Food Addiction, sciencedaily.com Evidence For Sugar Addiction: Behavioral and Neurochemical Effects of Intermittent, Excessive Sugar Intake, sciencedirect.com The Real Reason Diet Coke Cravings Are So Powerful, mashed.com Artificial Sweeteners: Sugar-Free But at What Cost?, health.harvard.edu Taco Bell, Trehalose, and the Trend of Transparency, foodbusinessnews.net Five Reasons the Diet Soda Myth Won't Die, nyt.com SMART Criteria, Wikipedia.org WOOP Website     HOW TO RATE AND REVIEW WELLNESS WHILE WALKING How to Leave a Review on Apple Podcasts on Your iOS Device 1.   Open Apple Podcast App (purple app icon that says Podcasts). 2.   Go to the icons at the bottom of the screen and choose "search" 3.   Search for "Wellness While Walking" 4.   Click on the SHOW, not the episode. 5.   Scroll all the way down to "Ratings and Reviews" section 6.   Click on "Write a Review" (if you don't see that option, click on "See All" first) 7.   Then you will be able to rate the show on a five-star scale (5 is highest rating) and write a review! 8.   Thank you! I so appreciate this!   How to Leave a Review on Apple Podcasts on a Computer  1.   Visit Wellness While Walking page on Apple Podcasts in your web browser (search for Apple Podcasts or click here)  https://www.apple.com/apple-podcasts/ 2.   Click on "Listen on Apple Podcasts" or "Open the App" 3.   This will open Apple Podcasts and put in search bar at top left "Wellness While Walking" 4.   This should bring you to the show, not a particular episode – click on the show's artwork 5.   Scroll down until you see "Rating and Reviews" 6.   Click on "See All" all the way to the right, near the Ratings and Review Section and its bar chart 7.   To leave a written review, please click on "Write a Review" 8.   You'll be able to leave a review, along with a title for it, plus you'll be able to rate the show on the 5-star scale (with 5 being the highest rating) 9.   Thank you so very much!! OTHER APPS WHERE RATINGS OR REVIEWS ARE POSSIBLE Spotify Goodpods Overcast (if you star certain episodes, or every one, that will help others find the show)  Castbox Podcast Addict Podchaser Podbean   HOW TO SHARE WELLNESS WHILE WALKING Tell a friend or family member about Wellness While Walking, maybe while you're walking together or lamenting not feeling 100% Follow up with a quick text with more info, as noted below! (My favorite is pod.link/walking because it works with all the apps!) Screenshot a favorite episode playing on your phone and share to social media or to a friend via text or email! Wellness While Walking on Apple – click the up arrow to share with a friend via text or email, or share to social media Wellness While Walking on Spotify -- click the up arrow to share with a friend via text or email, or share to social media Use this universal link for any podcast app: pod.link/walking – give it to friends or share on social media Tell your pal about the Wellness While Walking website Thanks for listening and now for sharing! : )       DISCLAIMER Neither I nor many of my podcast guests are doctors or healthcare professionals of any kind, and nothing on this podcast or associated content should be considered medical advice. The information provided by Wellness While Walking Podcast and associated material, by Whole Life Workshop and by Bermuda Road Wellness LLC is for informational and entertainment purposes only. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment, and before undertaking a new health care regimen, including walking.     Thanks for listening to Wellness While Walking, a walking podcast and a "best podcast for walking"!

Commentary by Dr. Jian'an Wang.

The American College of Obstetricians and Gynecologists (ACOG) does not recommend routine ultrasound measurement of the lower uterine segment (LUS) thickness as part of the evaluation for trial of labor after cesarean delivery (TOLAC). ACOG Practice Bulletin No. 205 (2019) on Vaginal Birth After Cesarean Delivery does not include LUS measurement among its recommendations for TOLAC candidacy assessment. The guideline focuses on clinical factors such as type of prior uterine incision, number of prior cesarean deliveries, and other obstetric history to determine TOLAC candidacy, and emphasizes that most women with one previous low-transverse cesarean delivery should be counseled about and offered TOLAC. But what if you find a likely uterine window at the LUS? Does that mandate a repeat C-section? This topic comes from Serena, one of our podcast family members. Listen in for details. 1. Dr. Chapa's Clinical Pearls, Dec 31., 2023: LUST FOR TOLAC; and follow up episode Jan 15, 20242. ACOG Practice Bulletin No. 205: Vaginal Birth After Cesarean Delivery. Committee on Practice Bulletins—Obstetrics Obstetrics and Gynecology. 2019;133(2):e110-e127. doi:10.1097/AOG.0000000000003078.3. Rozenberg P, Sénat MV, Deruelle P, et al. Evaluation of the Usefulness of Ultrasound Measurement of the Lower Uterine Segment Before Delivery of Women With a Prior Cesarean Delivery: A Randomized Trial. American Journal of Obstetrics and Gynecology. 2022. 4. Swift BE, Shah PS, Farine D. Sonographic Lower Uterine Segment Thickness After Prior Cesarean Section to Predict Uterine Rupture: A Systematic Review and Meta-Analysis. Acta Obstetricia Et Gynecologica Scandinavica. 2019. 5. McLeish SF, Murchison AB, Smith DM, et al. Predicting Uterine Rupture Risk Using Lower Uterine Segment Measurement During Pregnancy With Cesarean History: How Reliable Is It? A Review. Obstetrical & Gynecological Survey. 2023. 6. Jastrow N, Demers S, Chaillet N, et al. Lower Uterine Segment Thickness to Prevent Uterine Rupture and Adverse Perinatal Outcomes: A Multicenter Prospective study.7. American Journal of Obstetrics and Gynecology. 2016. 8. Guerby P, Bujold E, Chaillet N. Impact of Third-Trimester Measurement of Low Uterine Segment Thickness and Estimated Fetal Weight on Perinatal Morbidity in Women With Prior Cesarean Delivery. Journal of Obstetrics and Gynaecology Canada. JOGC. 2022.

Most diets fail because they never address what the food was doing for you emotionally. In this episode, Dr. Brendan McCarthy explains the stress-craving loop behind emotional eating, why ultra-processed foods feel impossible to resist, and how shame actually reinforces the cycle. You'll learn: • Why cravings feel automatic • How stress drives food urges • The “cue → urge → reward” loop • A simple 9-minute method to interrupt cravings This isn't about perfection or willpower. It's about understanding the pattern so you can finally begin to change it.   Citations:  Boswell, Rebecca G., and Hedy Kober. “Food Cue Reactivity and Craving Predict Eating and Weight Gain: A Meta-Analytic Review.” Obesity Reviews, vol. 17, no. 2, 2016, pp. 159–177. doi:10.1111/obr.12354. Use for: Food cues can trigger craving and eating even without true hunger. Berridge, Kent C., and Terry E. Robinson. “Liking, Wanting, and the Incentive-Sensitization Theory of Addiction.” American Psychologist, vol. 71, no. 8, 2016, pp. 670–679. doi:10.1037/amp0000059. Use for: “Wanting” food is not the same as true pleasure. Schultz, Wolfram, Peter Dayan, and P. Read Montague. “A Neural Substrate of Prediction and Reward.” Science, vol. 275, no. 5306, 1997, pp. 1593–1599. doi:10.1126/science.275.5306.1593. Use for: Dopamine helps encode reward prediction and learning. Wood, Wendy, and Dennis Rünger. “Psychology of Habit.” Annual Review of Psychology, vol. 67, 2016, pp. 289–314. doi:10.1146/annurev-psych-122414-033417. Use for: Habits form through repeated cue-context loops. Laborde, Sylvain, et al. “Effects of Voluntary Slow Breathing on Heart Rate and Heart Rate Variability: A Systematic Review and a Meta-Analysis.” Neuroscience & Biobehavioral Reviews, vol. 138, 2022, article 104711. doi:10.1016/j.neubiorev.2022.104711. Use for: Slow breathing supports parasympathetic regulation and stress reduction. Lieberman, Matthew D., et al. “Putting Feelings into Words: Affect Labeling Disrupts Amygdala Activity in Response to Affective Stimuli.” Psychological Science, vol. 18, no. 5, 2007, pp. 421–428. doi:10.1111/j.1467-9280.2007.01916.x. Use for: Naming emotions can reduce emotional reactivity. Gollwitzer, Peter M. “Implementation Intentions: Strong Effects of Simple Plans.” American Psychologist, vol. 54, no. 7, 1999, pp. 493–503. doi:10.1037/0003-066X.54.7.493. Use for: “If-then” plans improve behavior change under stress. Forman, Evan M., et al. “A Comparison of Acceptance- and Control-Based Strategies for Coping with Food Cravings: An Analog Study.” Behaviour Research and Therapy, vol. 45, no. 10, 2007, pp. 2372–2386. doi:10.1016/j.brat.2007.04.004. Use for: Acceptance and urge-surfing strategies help cravings pass without acting on them. Hall, Kevin D., et al. “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake.” Cell Metabolism, vol. 30, no. 1, 2019, pp. 67–77.e3. doi:10.1016/j.cmet.2019.05.008. Use for: Ultra-processed foods increase intake and reinforce overeating patterns.   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.

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And the evidence is catching up!For most of autism's diagnostic history, clinicians have repeated some version of the same number: autism is about four times more common in boys than in girls. That number has shaped which children get screened, which symptoms get recognized, and which ones get explained away as anxiety or shyness or a hormonal thing. Generations of autistic women and girls have been missed because the people doing the looking were taught to look for boys.In this episode, I walk through a 2026 study published in the BMJ that followed 2.7 million Swedish birth records over 35 years. The findings suggest the four-to-one ratio is collapsing — and in adolescent and adult diagnosis, it has either evened out or flipped. Autistic women were never rare. We were just being missed.Topics covered include:Why the four-to-one male-to-female ratio has dominated autism research and clinical practiceWhat "masking" or "camouflaging" means, and why it has cost so muchThe biological vs. diagnostic explanations for the apparent gender gap — and what this study tells us about bothWhy this looks like a catch-up effect rather than a sudden surge in autistic girlsWhat this means for autistic adults who got missed for decadesIf you'd like to know more about topics discussed in this episode, check out:"Time Trends in the Male to Female Ratio for Autism Incidence: Population Based, Prospectively Collected, Birth Cohort Study" by Caroline Fyfe et al."What Is the Male-to-Female Ratio in Autism Spectrum Disorder? A Systematic Review and Meta-Analysis" by Rachel Loomes et al."'Putting on My Best Normal:' Social Camouflaging in Adults With Autism Spectrum Conditions" by Laura Hull et al."Clinical Characteristics and Problems Diagnosing Autism Spectrum Disorder in Girls" by Hannah Young et al. Theme music: "Everything Feels New" by Evgeny Bardyuzha. All episodes written and produced by Kristen Hovet.Send in your questions or thoughts via email or audio or video recording for a chance to be featured on the show! My email address is otherautism@gmail.com Large files can be sent for free via WeTransfer. Buy me a coffee!Buy The Other Autism merch. Use code FREESHIP for free shipping on orders over $75 USD! The views, opinions, and experiences shared by guests on this podcast are their own and do not necessarily reflect those of the host or production team. The content is intended for informational purposes only and should not be taken as medical or professional advice. Please consult with a qualified healthcare provider before making any decisions related to your health, fitness, or wellness. 

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Cherry season is almost upon us, so we thought we'd revisit our cherry episode from last year. Enjoy

Bizeps-Curls schlagen Kurzhantel-Rudern beim Muskelwachstum – mit 11 Prozent gegen 5 Prozent. Eine Zahl aus dem Journal of Strength and Conditioning Research, die so ziemlich allem widerspricht, was Du in den vergangenen zehn Jahren über „echtes“ Krafttraining gehört hast.In dieser Folge räumt Mark mit einem der hartnäckigsten Dogmen der Fitness-Welt auf und zeigt Dir, warum reine Grundübungen Dich auf einem Plateau festkleben lassen können – und was Du stattdessen tun solltest. Du erfährst: Was die aktuelle Studienlage WIRKLICH zum Vergleich Grundübung vs. Isolation sagt – mit drei Ergebnissen, die selbst erfahrene Trainierende überraschen Wie die Wissenschaft zeigt, dass richtiges Krafttraining altersbedingte Muskelveränderungen nicht nur stoppt – sondern umkehrt Die Tischler-Formel: Wann Du den Hobel benötigst, wann Du zum Schleifpapier greifen solltest Die 80/20-Regel für effektives Krafttraining – und warum sie für die Ü40-Crew besonders wertvoll ist Drei Quick-Wins, die Du sofort umsetzen kannst Viel Spaß beim Reinhören!____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________

No weights for home pole dance conditioning? No problem! Dr. Rosy Boa addresses how pole dancers can build strength at home without gym access or heavy weights. She explains the basic strength principle of applying load and allowing recovery, noting weights are the most efficient for rapid, targeted gains, with free weights often preferable to machines for pole due to stabilization and range-of-motion demands. She then covers three accessible alternatives: isometrics (80–100% maximal effort holds for 1–5 seconds, scaling well but joint-angle specific), scalable bodyweight training (using variations such as changing points of contact, lever length, duration, reps, and power), and resistance bands (types, selecting by length/shape/resistance, variable tension through range, latex cautions, and use for assistance/spotting). She emphasizes consistency, enjoyable training, and doing the conditioning you will actually do.Are you a pole nerd interested in trying out online pole classes with Slink Through Strength? We'd love to have you! Use the code “podcast” for 10% off the Intro Pack and try out all of our unique online pole classes: https://app.acuityscheduling.com/catalog/25a67bd1/?productId=1828315&clearCart=true  Chapters:00:00 Welcome and Topic00:58 Membership Shoutouts02:59 Strength Basics05:56 Isometrics Explained09:11 Bodyweight Training12:04 Scaling Difficulty16:55 Resistance Bands24:52 Consistency Over Intensity28:47 Wrap Up and Invite Citations: Weights (machines or free weights) do have the largest effect size in building strength... but that's not necessarily our only goalWiedenmann T, Held S, Morat T, Rappelt L, Isenmann E, Berndsen E, Hopp NH, Donath L. The Effects of Different Resistance Training Modalities on Muscle Strength in Community-Dwelling Older Adults: A Network Meta-Analysis. Gerontology. 2025;71(7):576-588. doi: 10.1159/000546346. Epub 2025 May 27. PMID: 40452461. Isometrics scale with strength! (but you gotta PUSH: 80 - 100% effort and hold for a couple seconds)Lum D, Barbosa TM. Brief Review: Effects of Isometric Strength Training on Strength and Dynamic Performance. Int J Sports Med. 2019 May;40(6):363-375. doi: 10.1055/a-0863-4539. Epub 2019 Apr 3. PMID: 30943568. Bands do help with strength, might be more helpful with explosive/powerStanković D, Lazić A, Trajković N, Okičić M, Bubanj A, Vencúrik T, Gašić T, Bubanj S. Effects of Elastic Band Training on Physical Performance in Team Sports: A Systematic Review and Meta-Analysis. J Funct Morphol Kinesiol. 2025 Oct 17;10(4):402. doi: 10.3390/jfmk10040402. PMID: 41133592; PMCID: PMC12551113.

Send us Fan MailIn this episode of Journal Club, we wrap up a marathon recording session with a deep dive into the world of neonatal neuroprognostication. Daphna reviews a systematic review and meta-analysis from Pediatric Neurology that evaluates whether combining EEG and MRI provides better answers for families of preterm infants. While MRI remains a powerful tool for structural assessment, the data suggests that adding the functional insights of EEG significantly boosts specificity, particularly when predicting severe neurodevelopmental outcomes. We discuss the importance of timing these studies and the clinical value of sleep-wake cycling as a developmental milestone at the bedside.----Combined Use of Electroencephalography and Magnetic Resonance Imaging in the Prognostication of Neurodevelopmental Outcomes in Preterm Infants - A Systematic Review and Meta-Analysis. Forrest CD, Biagioni T, Liley HG, Lai MM, Colditz PB, Ware RS, Boyd RN, Roberts JA.Pediatr Neurol. 2026 Feb;175:116-129. doi: 10.1016/j.pediatrneurol.2025.11.005. Epub 2025 Nov 13.PMID: 41337899 Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Episode SummaryWomen have up to 70-80% lower creatine stores than men — and most of us have never been told that. In this episode Lisa digs into what that means for your brain, sleep, mood, muscles, and energy, and why creatine may be one of the most underreported tools in women's health right now.What You'll LearnWhat creatine actually is and why it matters beyond the gymWhy women have lower creatine stores — and why that gap widens in perimenopauseHow creatine supports brain energy (ATP) and what happens when levels run lowThe research on creatine and memory, processing speed, and mental clarityWhy creatine may reduce depression symptoms — more so in women than menCreatine and sleep: the adenosine mechanism, the 2024 women's RCT, and the 2025 perimenopause findingsThe University of Kansas Alzheimer's pilot studyCreatine + resistance training for muscle and bone health over 40How much to take: 5g for general health vs. 10g for brain-specific benefitsStart HereReady to heal your metabolism? thinlicious.com/happyStudies ReferencedCognitive Function & MemoryXu et al. (2024) — Creatine & Cognitive Function: Systematic Review & Meta-Analysis. Frontiers in Nutrition.Depression in WomenLyoo et al. (2012) — Creatine Augmentation for SSRI in Women With Major Depression. American Journal of Psychiatry.Systematic Review & Meta-Analysis: Creatine for Depression (2025). British Journal of Nutrition.SleepDworak et al. (2017) — Creatine Reduces Sleep Need & Homeostatic Sleep Pressure in Rats. Journal of Sleep Research.Aguiar Bonfim Cruz et al. (2024) — Creatine Improves Sleep in Naturally Menstruating Females. Nutrients.Gordji-Nejad et al. (2024) — Single Dose Creatine Improves Cognition During Sleep Deprivation. Scientific Reports.Hall et al. (2025) — Creatine + Resistance Training in Peri/Postmenopausal Women: Sleep, Cognition, Strength. JISSN.Alzheimer's DiseaseSmith et al. (2025) — Creatine Monohydrate Pilot in Alzheimer's: Brain Creatine & Cognition. Alzheimer's & Dementia.Brain Dosing: The Case for 10gDechent et al. (1999) — Creatine Increases Brain Creatine by 8.7% in Human Neuroimaging Study. American Journal of Physiology.Candow et al. — Higher Creatine Doses for Brain Bioenergetics. Journal of Psychiatry and Brain Science.Dr. Rhonda Patrick on 10g brain dosing (@foundmyfitness)Medical Disclaimer: For educational purposes only. Not medical advice. Always consult your doctor before starting any new supplement.

Welcome to Nerd Alert, a series of special episodes bridging the gap between marketing academia and practitioners. We're breaking down highly involved, complex research into plain language and takeaways any marketer can use.In this episode, Elena and Rob dig into a sweeping meta-analysis on advertising creativity. Together, they go over what it really means, when it moves the needle most, and why chasing memorability may be the wrong goal.Topics covered:•    [01:20] "A Meta-Analysis of When and How Advertising Creativity Works"•    [02:45] Originality alone isn't enough•    [04:55] High involvement vs. low involvement: where creativity doubles in power•    [06:55] The three theories behind why creative ads work•    [08:00] Why consumer judges outperform award shows at predicting brand outcomesTo learn more, visit marketingarchitects.com/podcastResources: Rosengren, S., Eisend, M., Koslow, S., & Dahlen, M. (2020). A meta-analysis of when and how advertising creativity works. Journal of Marketing, 84(6), 39–56. https://doi.org/10.1177/0022242920929288Get more research-backed marketing strategies by subscribing to The Marketing Architects on Apple Podcasts, Spotify, or wherever you listen to podcasts.

Dr. John Fleetham speaks with Dr. Leonardo Martinez about his article, "The Effectiveness of Isoniazid Preventive Treatment Among Contacts of Multidrug-Resistant Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis."

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For decades, an MS diagnosis came with outdated advice and significant uncertainty regarding starting a family. Today, the conversation has shifted from "Is it possible?" to "How do we optimize the journey?" This week, we're taking a deep dive into the essential considerations for family planning, managing MS during pregnancy, and the crucial postpartum period.  We're joined by Dr. Riley Bove, an Associate Professor of Neurology at UCSF and a leading expert in hormonal influences on MS. Dr. Bove brings her extensive research background and clinical expertise to help us understand how to navigate disease-modifying therapies while planning a family, the biological shifts that occur during pregnancy, and how to build a robust support system for the "fourth trimester." We're also sharing study results that provide some optimistic news for people experiencing MS-related depression. We'll tell you about a study that explains the actual changes in the immune system that occur when someone with MS exercises. If you get your health insurance on the Affordable Care Act online marketplace, we'll explain why health economists feel certain that your premiums will be going up again next year. And we're also sharing some sobering research that highlights systemic inequities that prevent people with MS who rely on Medicaid from accessing high-efficacy disease-modifying therapies. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: MS and family planning, pregnancy, and postpartum  :22 STUDY: High-efficacy disease-modifying therapies are not available to all Medicaid recipients   1:08 Millions have failed to renew their ACA individual health insurance plans  5:05 STUDY: Cognitive-behavioral therapy improves MS-related depression  9:32 STUDY: Researchers identify the biological mechanisms that are impacted when people with MS exercise  11:29 Dr. Riley Bove discusses family planning, pregnancy, and postpartum issues that affect women with MS  14:48 Share this episode  35:31 Next week  35:50 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/453 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com STUDY: Access to High-Efficacy Therapies for Multiple Sclerosis Under Medicaid: Variation in Coverage and Utilization Across States https://aan.com/msa/Public/Events/AbstractDetails/61520 STUDY: Effectiveness of Cognitive Behavioral Therapy for Depression in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis https://journals.lww.com/md-journal/fulltext/2026/04170/effectivess_of_cognitive_behavioral_therapy_for.27.aspx STUDY: Physical Exercise Modulates T Cell Activity and Mitigates Synaptic Dysfunction in Multiple Sclerosis Through Vagus Nerve Engagement https://sciencedirect.com/science/article/abs/pii/S0889159126002710 UCSF Clinical Trials: Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA) https://clinicaltrials.ucsf.edu/trial/NCT06940323 AbleNOW https://ablenow.com JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on X, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 453 Guest: Dr. Riley Bove Privacy Policy

Interview with Alessandra Fanciulli, MD, PhD, and Eduardo de Pablo-Fernández, MD, PhD, authors of Phenoconversion in Pure Autonomic Failure: A Systematic Review and Meta-Analysis. Hosted by Cynthia E. Armand, MD. Related Content: Phenoconversion in Pure Autonomic Failure Pure Autonomic Failure and Central Synucleinopathy Risk

Interview with Alessandra Fanciulli, MD, PhD, and Eduardo de Pablo-Fernández, MD, PhD, authors of Phenoconversion in Pure Autonomic Failure: A Systematic Review and Meta-Analysis. Hosted by Cynthia E. Armand, MD. Related Content: Phenoconversion in Pure Autonomic Failure Pure Autonomic Failure and Central Synucleinopathy Risk

Join Dr. Jeff Jarvis for part II of his interview with podcase friend and frequent contributor, now-Dr Tanner Smida where we discuss his defense of his PhD. Dr Smida discusses four papers that inform cardiac arrest resuscitation, as well as lessons he learned about conducting well-designed observational studies. Although his dissertation was built around only 4 papers, here is Dr Smida's entire bibliography:1.        Smida T, Willson C, Salerno J, Weiss L, Salcido DD. Can you get there from here? An analysis of walkability among PulsePoint CPR alert dispatches. Resuscitation. 2020 Mar 1;148:135-139. 2.        Patterson PD, Weiss LS, Weaver MD, Salcido DD, Opitz SE, Okerman TS, Smida TT, Martin SE, Guyette FX, Martin-Gill C, Callaway CW. Napping on the night shift and its impact on blood pressure and heart rate variability among emergency medical services workers: study protocol for a randomized crossover trial. Trials. 2021 Mar 16;22(1):212. 3.        Smida T, Koller AC, Menegazzi JJ, Salcido DD. Early cytotoxic lymphocyte localization to the brain following resuscitation in a porcine model of asphyxial cardiac arrest: A pilot study. Resusc Plus. 2021 Apr 28;6:100125. 4.        Smida T, Salerno J, Weiss L, Martin-Gill C, Salcido DD. PulsePoint dispatch associated patient characteristics and prehospital outcomes in a mid-sized metropolitan area. Resuscitation. 2022 Jan;170:36-43. 5.        Smida T, Menegazzi JJ, Crowe RP, Weiss LS, Salcido DD. Association of prehospital hypotension depth and dose with survival following out-of-hospital cardiac arrest. Resuscitation. 2022 Sep 30;180:99-107. 6.        Smida T, Menegazzi JJ, Crowe RP, Bardes J, Scheidler JF, Salcido DD. Association of prehospital post-resuscitation peripheral oxygen saturation with survival following out-of-hospital cardiac arrest. Resuscitation. 2022 Dec;181:28-36. 7.        Smida T, Menegazzi J, Crowe R, Scheidler J, Salcido D, Bardes J. A Retrospective Nationwide Comparison of the iGel and King Laryngeal Tube Supraglottic Airways for Out-of-Hospital Cardiac Arrest Resuscitation. Prehosp Emerg Care. 2023 Feb 13:1-7. 8.        Smida T, Menegazzi J, Scheidler J, Martin PS, Salcido D, Bardes J; CARES Surveillance Group. A retrospective comparison of the King Laryngeal Tube and iGel supraglottic airway devices: A study for the CARES surveillance group. Resuscitation. 2023 Apr 28:109812. 9.        Smida T, Price BS, Scheidler J, Crowe R, Wilson A, Bardes J. Stay and play or load and go? The association of on-scene advanced life support interventions with return of spontaneous circulation following traumatic cardiac arrest. Eur J Trauma Emerg Surg. 2023 May 10. 10.  Smida T, Menegazzi JJ, Crowe RP, Salcido D, Martin PS, Scheidler J, James Bardes. The Association of Combined Prehospital Hypotension and Hypoxia With Outcomes Following Out-of-Hospital Cardiac Arrest Resuscitation. Prehosp Emerg Care. 2023 Jul 26:1-9. 11.  Smida T, Menegazzi JJ, Crowe RP, Salcido DD, Bardes J, Myers B. The Association of Prehospital End-Tidal Carbon Dioxide with Survival Following Out-of-Hospital Cardiac Arrest. Prehosp Emerg Care. 2023 Sep 26:1-7. 12.  Smida T, Bonasso P, Bardes J, Price BS, Seifarth F, Gurien L, Maxson R, Letton R. Reverse shock index multiplied by the motor component of the Glasgow Coma Scale predicts mortality and need for intervention in pediatric trauma patients. J Trauma Acute Care Surg. 2024 Jan 26. 13.  Suchko S, Smida T, Crowe RP, Menegazzi JJ, Scheidler JF, Shukis M, Martin PS, Bardes JM, Salcido DD. The association of clinical, treatment, and demographic characteristics with rearrest in a national dataset. Resuscitation. 2024 Mar;196:110135. 14.  Smida T, Crowe R, Jarvis J, Ratcliff T, Goebel M. A retrospective comparison of upper and lower extremity intraosseous access during out-of-hospital cardiac arrest resuscitation. Prehosp Emerg Care. 2024 Feb 28:1-23. 15.  Smida T, Crowe RP, Martin PS, Scheidler JF, Shukis M, Price BS, Bardes JM. A retrospective, multi-agency ‘target trial emulation' for the comparison of post-resuscitation epinephrine to norepinephrine.  Resuscitation.  2024 April16.  Smida T, Crowe RP, Merrill PW, Scheidler JF. A Simpler Method for Choosing Adult i-gel Size: An Evaluation of Real-World Prehospital Data. Air Med J. 2024 May-Jun;43(3):259-261. 17.  Niemann B, Zarfoss E, Victory J, Smida T, Petros K, Sestito M, Bardes J. Evaluation of Oral Vasoactive Medications to Maintain Mean Arterial Pressure in Spinal Cord Injury. J Surg Res. 2024 Aug 12;302:339-346. 18.  Smida T, Price BS, Mizener A, Crowe RP, Bardes JM. Prehospital Post-Resuscitation Vital Sign Phenotypes are Associated with Outcomes Following Out-of-Hospital Cardiac Arrest. Prehosp Emerg Care. 2024 Aug 15:1-8. 19.  Smida T, Voges L, Crowe R, Scheidler J, Bardes J. Prehospital Transcutaneous Cardiac Pacing in the United States: Treatment Epidemiology, Predictors of Treatment Failure, and Associated Outcomes. Prehosp Emerg Care. 2024 Sep 4:1-8. 20.  Smida T, Dayal S, Bardes J, Scheidler J. Association of Prehospital Rearrest With Outcome Following Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis of Observational Studies. Prehosp Emerg Care. 2024 Oct 18:1-9. 21.  Smida T, Cheskes S, Crowe R, Price BS, Scheidler J, Shukis M, Martin PS, Bardes J. The association between initial defibrillation dose and outcomes following adult out-of-hospital cardiac arrest resuscitation: A retrospective, multi-agency study. Resuscitation. 2025 Jan 23:110507. 22.  Smida T, Crowe R, Price BS, Scheidler J, Martin PS, Shukis M, Bardes J. A retrospective 'target trial emulation' comparing amiodarone and lidocaine for adult out-of-hospital cardiac arrest resuscitation. Resuscitation. 2025 Jan 23:110515. 23.  Nordstrom NK, Smida T, Bardes JM, Brown C, Wilson A. A contemporary analysis of prehospital crystalloid resuscitation after trauma. Injury. 2025 Jul 15:112614.24.  Kimbrell JM, Kreinbrook JA, Stebel J, Smida T, Shekhar AC, Rodriguez D, Mara A, Mullen J, Miele A, Vega J. Delays to chest compressions and defibrillation after prehospital rearrest. Am J Emerg Med. 2025 Dec;98:118-123. 25.  Smida T, Kimbrell JM, Kreinbrook JA, Gan GH, Odom W, Bouthillet T, Walsh B, Shukis M, Scheidler J, Martin PS, Moskowitz A, Counts CR, Bardes J. The prevalence of sustained electrical capture during prehospital transcutaneous pacing: a multicenter observational study. Resuscitation. 2025 Dec 22:110934. 26.  Smida T, Harvey W, Bonasso P, Price BS, Martin PS, Bardes J. The ability of statewide prehospital pediatric blood transfusion protocols to predict early in-hospital blood product administration: A National Trauma Data Bank analysis. J Trauma Acute Care Surg. 2026 Jan 20. 27.  Smida T, Handyside R, Crowe R, McDonald A, Scheidler J, Bardes J. Factors associated with successful intravenous access in the prehospital setting. Prehosp Emerg Care. 2026 Feb 25:1-12.28.  Smida T, Handyside R, Crowe R, Merrill PW, Scheidler J, Bardes J. A retrospective comparison of plunger-type and band-type mechanical chest compression devices for prehospital resuscitation. Prehosp Emerg Care. 2026 Feb 25:1-12. 29.  Kreinbrook JA, Kimbrell JM, Gan GH, Odom W, Shukis M, Bardes J, Smida ...

In this episode Dr. Rosy Boa discusses regression in pole dancing—plateaus, losing tricks, and fluctuating capacity—as a normal outcome of changing life circumstances like stress, finances, injury, caregiving, and disability, including impacts from COVID. She argues pole should not be prioritized over basic needs and warns against tying self-worth to specific tricks, which can create shame and identity crises when abilities change. As a coaching approach, she recommends building the skill of “noticing”: tuning into proprioception and interoception, identifying what feels physically pleasurable, and cultivating aesthetic appreciation beyond technical perfection. She suggests practicing by watching peer-level dancers and identifying non-technical qualities (expression, musicality, lines, novelty) to develop a softer lens that can be turned inward, supporting motivation, enjoyment, and longevity in pole.Are you a pole nerd interested in trying out online pole classes with Slink Through Strength? We'd love to have you! Use the code “podcast” for 10% off the Intro Pack and try out all of our unique online pole classes: https://app.acuityscheduling.com/catalog/25a67bd1/?productId=1828315&clearCart=true  Citations: Loureiro F, Ringold SM, Aziz-Zadeh L. Interoception in Autism: A Narrative Review of Behavioral and Neurobiological Data. Psychol Res Behav Manag. 2024 May 3;17:1841-1853. doi: 10.2147/PRBM.S410605. PMID: 38716258; PMCID: PMC11075678. (Movement/exercise is effective in supporting joint health, especially in patients who already have osteoarthritis)  Nayab S, Bilal Elahi M. The Impact of Exercise Interventions on Pain, Function, and Quality of Life in Patients With Osteoarthritis: A Systematic Review and Meta-Analysis. Cureus. 2024 Nov 25;16(11):e74464. doi: 10.7759/cureus.74464. PMID: 39726491; PMCID: PMC11669877. Chapters:00:00 Welcome and Setup00:53 Why We Regress01:29 Life Shifts and Capacity03:30 Losing Tricks Is Normal04:41 Identity Beyond Tricks06:44 Noticing What Feels Good09:14 Intrinsic Motivation in Practice11:39 Appreciating Others Differently13:47 Exercise to Train Your Eye16:55 Beauty in Every Stage20:10 Softness and Self Kindness20:39 Wrap Up and Shout Outs

Episode 172: In this episode of Critical Thinking - Bug Bounty Podcast trying out a new structure of episode: a Meta Analysis of sorts of many Source Code Review techniques. This episode features tips gathered from Shubs, Rafax, and FSI. Justin highlights best approaches, patterns, and common pitfalls.Follow us on twitter at: https://x.com/ctbbpodcastGot any ideas and suggestions? Feel free to send us any feedback here: info@criticalthinkingpodcast.ioShoutout to YTCracker for the awesome intro music!====== Links ======Follow your hosts Rhynorater, rez0 and gr3pme on X: https://x.com/Rhynoraterhttps://x.com/rez0__https://x.com/gr3pmeCritical Research Lab:https://lab.ctbb.show/ ====== Ways to Support CTBBPodcast ======Hop on the CTBB Discord at https://ctbb.show/discord!We also do Discord subs at $25, $10, and $5 - premium subscribers get access to private masterclasses, exploits, tools, scripts, un-redacted bug reports, etc.You can also find some hacker swag at https://ctbb.show/merch!Today's Sponsor: Adobe - Get 10% bonus for valid AI vulnerabilities in Adobe Stock and Lightroom Web. Use code: CTBB063026 in your report.Expires June 30, 2026. ====== This Week in Bug Bounty ======Open-source security testing: the Bug Bounty guide to code analysishttps://www.yeswehack.com/learn-bug-bounty/open-source-guide-code-analysis?utm_source=youtube&utm_medium=sponsor-critical-thinking&utm_campaign=open-source-guide-code-analysis====== Resources ======Abusing Windows, .NET quirks, and Unicode Normalization to exploit DNN (DotNetNuke)https://slcyber.io/research-center/abusing-windows-net-quirks-and-unicode-normalization-to-exploit-dnn-dotnetnuke/#:~:text=across%20different%20languages.-,A%20MUST%2DKNOW%20BEHAVIOUR%20OF%20PATH.COMBINE,-Another%20key%20implementation====== Timestamps ======(00:00:00) Introduction(00:06:49) Tracing Data Flow, knowing where your playload is landing, and developer mistakes.(00:17:33) Mapping the software(00:24:46) Sniffing for blood(00:31:54) Common Patterns and Pitfalls

Send us Fan MailLife has a way of getting lifely — and this episode was born right in the middle of mine. In Episode 208, I get personal about a season that brought me to stillness, to my car, to my breath — and ultimately, to a word that changed everything for me this year. If you have ever found yourself waiting for the perfect moment to start again, or wondering if the hard thing you are going through has any light in it at all, this episode is for you. Come as you are. Start where you are. That is always enough.From a beloved novel to a spontaneous act of love from my son, from peer-reviewed science to a 14th century poet — I weave together the stories, the research, and the reminders that the light within you has never gone out. It may be quiet. It may be flickering. But it is there, and it has been there your whole life. I hope this episode helps you see it.Quote of the week: "I wish I could show you, when you are lonely or in darkness, the astonishing light of your own being." — Hafiz of ShirazFina's 2025 Reading ListThe 48 Laws of Power — Robert GreeneThe Prince — Niccolò MachiavelliThe Art of War — Sun TzuQuotations from the Works of Mao Tse-Tung — Mao ZedongRight Thing Right Now — Ryan HolidayAwaken the Giant Within — Tony RobbinsThe Big Leap — Gay HendricksEmotional Intelligence — Bradberry & GreavesA Return to Love — Marianne WilliamsonNo Mud No Lotus — Thich Nhat HanhTao Te Ching — Translated by Stephen MitchellMindful Investor — Maria GonzalezEducated — Tara WestoverSlaughterhouse-Five — Kurt Vonnegut1929 — Andrew Ross SorkinBooks ReferencedDoerr, Anthony. All the Light We Cannot See. Scribner, 2014.Frankl, Viktor E. Man's Search for Meaning. Beacon Press, 1959.Greene, Robert. The 48 Laws of Power. Viking Press, 1998.Holiday, Ryan. The Obstacle Is the Way. Portfolio/Penguin, 2014.Hanh, Thich Nhat. Mud and Lotus. Parallax Press.Westover, Tara. Educated. Random House, 2018.Peer-Reviewed ResearchCunha, L.F., et al. "Positive Psychology and Gratitude Interventions: A Randomized Clinical Trial." Frontiers in Psychology, Vol. 10, March 2019. https://doi.org/10.3389/fpsyg.2019.00584Martínez-Martí, M.L., et al. "The Effects of Gratitude Interventions: A Systematic Review and Meta-Analysis." PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC10393216/Lundman, B., et al. "Inner Strength — A Systematic Review of Qualitative Empirical Studies." PubMed Central,1990–2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC12375945/Holmedal Byrne & Gustafsson. "Resilience Theory: Core Concepts and Research Insights." Cited in Positive Psychology, 2024. https://positivepsychology.com/resilience-theory/PoetryHafiz of Shiraz. "I Wish I Could Show You." 14th century. English translation widely attributed to Daniel Ladinsky, The Gift, Penguin Compass, 1999.MediaAll the Light We Cannot See. Netflix series, 2023. Directed Let's go, let's get it done.Get more information at: http://projectweightloss.org

In this episode of The Poultry Nutrition Blackbelt Podcast, Emmanuel Nuamah, Research Assistant at Jeonbuk National University in South Korea, explains how meta-analysis combines data from multiple studies to deliver more reliable, evidence-based nutritional strategies for broilers and layers. He walks through the full meta-analysis process, from the PICO framework to bias screening, and discusses how machine learning is making the method even more dynamic and powerful. Listen now on all major platforms!"Meta-analysis aggregates individual studies to reveal nutritional strategies that hold across real-world variability in commercial production."Meet the guest: Emmanuel Nuamah is a Research Assistant at Jeonbuk National University in South Korea, specializing in broiler and swine nutrition, digestive physiology, and meta-analysis. His work focuses on building evidence-based nutritional strategies from pooled study data. He holds a B.Sc. in Agriculture and an M.Phil. in Animal Science from the University of Cape Coast, Ghana.Liked this one? Don't stop now — Here's what we think you'll love!What you'll learn:(00:00) Highlight(01:39) Introduction(03:14) Meta-analysis overview(05:25) Heterogeneity and context(06:45) PICO framework explained(08:22) Screening and bias removal(12:17) AI and machine learning role(13:41) Closing thoughtsThe Poultry Nutrition Blackbelt Podcast is trusted and supported by innovative companies like:* Fortiva* Kemin- Anitox- DietForge- Poultry Science Association

In today's Friday deep dive, Vanessa breaks down one of the most important new studies in fat loss and body recomposition — along with her recent interview with Dr. Eric Helms. This episode explores a cutting-edge meta-regression by Dr. Eric Helms, Dr. Eric Trexler, and Dr. Martin Refalo on protein intake during caloric restriction — and what it means for preserving muscle while losing fat.  Last Day to Save on the PSMF Library (Pre-Order) Final hours to lock in the launch pricing

Vanessa Spina is joined by Dr. Eric Helms to break down the latest research on protein intake during fat loss and what it really takes to preserve muscle while dieting.

Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826261424814

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. Zain Khalpey, an assistant attending surgeon at NewYork-Presbyterian/Columbia University Irving Medical Center, NY, USA, adjunct assistant professor of surgery at Columbia University Irving Medical Center, NY, USA, and Chief Medical AI Officer, Chair of Applied Clinical AI, and Director of Applied Translational Artificial Research Institute (ATARI), AZ, USA, about utilizing artificial intelligence (AI) in cardiothoracic surgery. Chapters 00:00 Intro 01:42 Upcoming CTSNet Activities 03:01 Website Transition 03:54 JANS 1, Mech vs Bio AVR in 50–70 YO 08:16 JANS 2, Abnormal Bleeding in OR 10:26 JANS 3, Intraop Assessment RV Function 11:54 JANS 4, Laser Anastomosis System CABG 14:49 Video 1, RAMT AVR Hemiarch Replacement 16:23 Video 2, Big Cyst & Small Incisions 17:33 Video 3, Left VATS Pneumonectomy 19:55 Dr. Khalpey, AI in CT Surgery 30:28 Upcoming Events 31:48 Closing They discuss the importance of ethical AI being and address risk scores. The conversation also covers the application of AI in preoperative, intraoperative, and postoperative settings, as well as predictive algorithms and the benefits of integrating AI within cardiothoracic surgery. Additionally, they emphasize that there will always be a need for surgeons, as AI cannot replace human expertise.   Joel also highlights recent JANS articles on a systematic review and meta-analysis on mechanical vs biological aortic valve replacement in patients aged 50-70 years, an observational study of inter-rater reliability between anesthetists and surgeons on abnormal bleeding in the cardiac operating room, advancing intraoperative assessment of right ventricular function, and the excimer laser assisted non-occlusive anastomosis (ELANA) anastomotic system surgical technique to construct distal anastomoses using a novel device in coronary artery bypass grafting.  In addition, Joel explores a right anterior minithoractomy aortic valve replacement, ascending aorta, and hemiarch repair, thoracoscopic resection of a large mediastinal cyst, and left VATS pneumonectomy in pediatric pulmonary mucoepidermoid carcinoma. Before closing, Joel highlights upcoming events in CT surgery.    JANS Items Mentioned  1. Mechanical Versus Biological Aortic Valve Replacement in Patients Aged 50-70 Years: A Systematic Review and Meta-Analysis  2. Abnormal Bleeding in the Cardiac Operating Room: An Observational Study of Inter-Rater Reliability Between Anesthetists and Surgeons  3. Echocardiographic Correlates of Pressure-Volume-Derived Indices: Advancing Intraoperative Assessment of Right Ventricular Function  4. The Excimer Laser Assisted Non-Occlusive Anastomosis (ELANA) Anastomotic System Surgical Technique to Construct Distal Anastomoses Using a Novel Device in Coronary Artery Bypass Grafting  CTSNet Content Mentioned  1. Right Anterior Minithoractomy Aortic Valve Replacement, Ascending Aorta, and Hemiarch Repair   2. When Size Is Not a Limitation: Thoracoscopic Resection of a Large Mediastinal Cyst   3. Left VATS Pneumonectomy in Pediatric Pulmonary Mucoepidermoid Carcinoma   Other Items Mentioned  1. Website Blackout Notice!  2. Career Center   3. CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

I posted a meta-analysis showing PRP doesn't beat saline for tennis elbow. The regenerative medicine community came for me, hard. This episode walks through the incident, what the evidence states, why the comparator you choose determines the conclusion you reach, and what the pushback reveals about incentives in musculoskeletal medicine. References Antunes Júnior et al. (2026). Platelet-rich plasma does not improve pain or function in patients with lateral epicondylitis as compared with placebo: A meta-analysis of randomized clinical trials. American Journal of Sports Medicine. Coombes BK et al. (2010). Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: A systematic review of randomised controlled trials. The Lancet, 376(9754), 1751–1767. Gosens T et al. (2011). Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: A double-blind randomized controlled trial with 2-year follow-up. American Journal of Sports Medicine, 39(6), 1200–1208. Kamble P et al. (2023). Is ultrasound (US)-guided platelet-rich plasma injection more efficacious as a treatment modality for lateral elbow tendinopathy than US-guided steroid injection? A prospective triple-blinded study with midterm follow-up. Clinics in Orthopedic Surgery, 15(3), 454–462. Krogh TP et al. (2013). Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: A randomized, double-blind, placebo-controlled trial. American Journal of Sports Medicine, 41(3), 625–635. Oeding JF et al. (2025). Platelet concentration explains variability in outcomes of platelet-rich plasma for lateral epicondylitis: A high dose is critical for a positive response — A systematic review and meta-analysis with meta-regression. American Journal of Sports Medicine, 53(10), 2489–2496. Orchard JW. (2025). Rock, paper, scissors: Resolving the conflicting results of randomized trials involving corticosteroid, platelet rich plasma (PRP) and placebo injections. JSAMS Plus, 5, 100081. Register for the complete shoulder online course Register for my Brisbane workshop Connect with Jared and guests: Jared on Instagram: @‌shoulder_physio Jared on X: @‌jaredpowell12 See our Disclaimer here: The Shoulder Physio - Disclaimer

Join Dr. Jeff Jarvis as he interviews podcase friend and frequent contributor, now-Dr Tanner Smida for the first of a two-part interview where we discuss his defense of his PhD. Dr Smida discusses four papers that inform cardiac arrest resuscitation, as well as lessons he learned about conducting well-designed observational studies. Although his dissertation was built around only 4 papers, here is Dr Smida's entire bibliography:1.        Smida T, Willson C, Salerno J, Weiss L, Salcido DD. Can you get there from here? An analysis of walkability among PulsePoint CPR alert dispatches. Resuscitation. 2020 Mar 1;148:135-139. doi: 10.1016/j.resuscitation.2019.12.038. Epub 2020 Jan 18. PMID: 31962177.2.        Patterson PD, Weiss LS, Weaver MD, Salcido DD, Opitz SE, Okerman TS, Smida TT, Martin SE, Guyette FX, Martin-Gill C, Callaway CW. Napping on the night shift and its impact on blood pressure and heart rate variability among emergency medical services workers: study protocol for a randomized crossover trial. Trials. 2021 Mar 16;22(1):212. doi: 10.1186/s13063-021-05161-4. PMID: 33726840; PMCID: PMC7962082.3.        Smida T, Koller AC, Menegazzi JJ, Salcido DD. Early cytotoxic lymphocyte localization to the brain following resuscitation in a porcine model of asphyxial cardiac arrest: A pilot study. Resusc Plus. 2021 Apr 28;6:100125. doi: 10.1016/j.resplu.2021.100125. PMID: 34223383; PMCID: PMC8244478.4.        Smida T, Salerno J, Weiss L, Martin-Gill C, Salcido DD. PulsePoint dispatch associated patient characteristics and prehospital outcomes in a mid-sized metropolitan area. Resuscitation. 2022 Jan;170:36-43. doi: 10.1016/j.resuscitation.2021.11.007. Epub 2021 Nov 11. PMID: 34774964.5.        Smida T, Menegazzi JJ, Crowe RP, Weiss LS, Salcido DD. Association of prehospital hypotension depth and dose with survival following out-of-hospital cardiac arrest. Resuscitation. 2022 Sep 30;180:99-107. doi: 10.1016/j.resuscitation.2022.09.018. Epub ahead of print. PMID: 36191809.6.        Smida T, Menegazzi JJ, Crowe RP, Bardes J, Scheidler JF, Salcido DD. Association of prehospital post-resuscitation peripheral oxygen saturation with survival following out-of-hospital cardiac arrest. Resuscitation. 2022 Dec;181:28-36. doi: 10.1016/j.resuscitation.2022.10.011. Epub 2022 Oct 19. PMID: 36272616.7.        Smida T, Menegazzi J, Crowe R, Scheidler J, Salcido D, Bardes J. A Retrospective Nationwide Comparison of the iGel and King Laryngeal Tube Supraglottic Airways for Out-of-Hospital Cardiac Arrest Resuscitation. Prehosp Emerg Care. 2023 Feb 13:1-7. doi: 10.1080/10903127.2023.2169422. Epub ahead of print. PMID: 36652451.8.        Smida T, Menegazzi J, Scheidler J, Martin PS, Salcido D, Bardes J; CARES Surveillance Group. A retrospective comparison of the King Laryngeal Tube and iGel supraglottic airway devices: A study for the CARES surveillance group. Resuscitation. 2023 Apr 28:109812. doi: 10.1016/j.resuscitation.2023.109812. Epub ahead of print. PMID: 37120129.9.        Smida T, Price BS, Scheidler J, Crowe R, Wilson A, Bardes J. Stay and play or load and go? The association of on-scene advanced life support interventions with return of spontaneous circulation following traumatic cardiac arrest. Eur J Trauma Emerg Surg. 2023 May 10. doi: 10.1007/s00068-023-02279-9. Epub ahead of print. PMID: 37162554.10.  Smida T, Menegazzi JJ, Crowe RP, Salcido D, Martin PS, Scheidler J, James Bardes. The Association of Combined Prehospital Hypotension and Hypoxia With Outcomes Following Out-of-Hospital Cardiac Arrest Resuscitation. Prehosp Emerg Care. 2023 Jul 26:1-9. doi: 10.1080/10903127.2023.2238820. Epub ahead of print. PMID: 37494278.11.  Smida T, Menegazzi JJ, Crowe RP, Salcido DD, Bardes J, Myers B. The Association of Prehospital End-Tidal Carbon Dioxide with Survival Following Out-of-Hospital Cardiac Arrest. Prehosp Emerg Care. 2023 Sep 26:1-7. doi: 10.1080/10903127.2023.2262566. Epub ahead of print. PMID: 37751228.12.  Smida T, Bonasso P, Bardes J, Price BS, Seifarth F, Gurien L, Maxson R, Letton R. Reverse shock index multiplied by the motor component of the Glasgow Coma Scale predicts mortality and need for intervention in pediatric trauma patients. J Trauma Acute Care Surg. 2024 Jan 26. doi: 10.1097/TA.0000000000004258. Epub ahead of print. PMID: 38273438.13.  Suchko S, Smida T, Crowe RP, Menegazzi JJ, Scheidler JF, Shukis M, Martin PS, Bardes JM, Salcido DD. The association of clinical, treatment, and demographic characteristics with rearrest in a national dataset. Resuscitation. 2024 Mar;196:110135. doi: 10.1016/j.resuscitation.2024.110135. Epub 2024 Feb 7. PMID: 38331343.14.  Smida T, Crowe R, Jarvis J, Ratcliff T, Goebel M. A retrospective comparison of upper and lower extremity intraosseous access during out-of-hospital cardiac arrest resuscitation. Prehosp Emerg Care. 2024 Feb 28:1-23. doi: 10.1080/10903127.2024.2321285. Epub ahead of print. PMID: 38416867.15.  Smida T, Crowe RP, Martin PS, Scheidler JF, Shukis M, Price BS, Bardes JM. A retrospective, multi-agency ‘target trial emulation' for the comparison of post-resuscitation epinephrine to norepinephrine.  Resuscitation.  2024 April; doi: 10.1016/j.resuscitation.2024.110201. Epub ahead of print.16.  Smida T, Crowe RP, Merrill PW, Scheidler JF. A Simpler Method for Choosing Adult i-gel Size: An Evaluation of Real-World Prehospital Data. Air Med J. 2024 May-Jun;43(3):259-261. doi: 10.1016/j.amj.2024.03.011. Epub 2024 Apr 5. PMID: 38821710.17.  Niemann B, Zarfoss E, Victory J, Smida T, Petros K, Sestito M, Bardes J. Evaluation of Oral Vasoactive Medications to Maintain Mean Arterial Pressure in Spinal Cord Injury. J Surg Res. 2024 Aug 12;302:339-346. doi: 10.1016/j.jss.2024.07.059. Epub ahead of print. PMID: 39137515.18.  Smida T, Price BS, Mizener A, Crowe RP, Bardes JM. Prehospital Post-Resuscitation Vital Sign Phenotypes are Associated with Outcomes Following Out-of-Hospital Cardiac Arrest. Prehosp Emerg Care. 2024 Aug 15:1-8. doi: 10.1080/10903127.2024.2386445. Epub ahead of print. PMID: 39088816.19.  Smida T, Voges L, Crowe R, Scheidler J, Bardes J. Prehospital Transcutaneous Cardiac Pacing in the United States: Treatment Epidemiology, Predictors of Treatment Failure, and Associated Outcomes. Prehosp Emerg Care. 2024 Sep 4:1-8. doi: 10.1080/10903127.2024.2393768. Epub ahead of print. PMID: 39150824.20.  Smida T, Dayal S, Bardes J, Scheidler J. Association of Prehospital Rearrest With Outcome Following Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis of Observational Studies. Prehosp Emerg Care. 2024 Oct 18:1-9. doi: 10.1080/10903127.2024.2408628. Epub ahead of print. PMID: 39321386.21.  Smida T, Cheskes S, Crowe R, Price BS, Scheidler J, Shukis M, Martin PS, Bardes J. The association between initial defibrillation dose and outcomes following adult out-of-hospital cardiac arrest resuscitation: A retrospective, multi-agency study. Resuscitation. 2025 Jan 23:110507. doi: 10.1016/j.resuscitation.2025.110507. Epub ahead of print. PMID: 39855423.22.  Smida T, Crowe R, Price BS, Scheidler J, Martin PS, Shukis M, Bardes J. A retrospective 'target trial emulation' comparing amiodarone and lidocaine for adult out-of-hospital cardiac arrest resuscitation. Resuscitation. 2025 Jan 23:110515. doi: 10.1016/j.resuscitation.2025.110515. Epub ahead of print. PMID: 39863130.23.  Nordstrom NK, Smida T, Bardes JM, Brown C, Wilson A. A contemporary analysis of pr...

Send us Fan MailDescription: An immersive reading of Sommelier by by Suraj Bala with reflection on reflection, death, resurrection, candles and em dashes. Work:Poem: https://jamanetwork.com/journals/jamaoncology/article-abstract/2839156Bala S. Sommelier. JAMA Oncol. 2025;11(11):1399. doi:10.1001/jamaoncol.2025.2896References: Meditation for the Primary and Secondary Prevention of Cardiovascular Disease. Rees K, Takeda A, Court R, et al. The Cochrane Database of Systematic Reviews. 2024;2:CD013358. doi:10.1002/14651858.CD013358.pub2.Meditation Programs for Psychological Stress and Well-Being: A Systematic Review and Meta-Analysis. Goyal M, Singh S, Sibinga EM, et al. JAMA Internal Medicine. 2014;174(3):357-68. doi:10.1001/jamainternmed.2013.13018.Inner Engineering Practices and Advanced 4-Day Isha Yoga Retreat Are Associated With Cannabimimetic Effects With Increased Endocannabinoids and Short-Term and Sustained Improvement in Mental Health: A Prospective Observational Study of Meditators. Sadhasivam S, Alankar S, Maturi R, et al. Evidence-Based Complementary and Alternative Medicine : eCAM. 2020;2020:8438272. doi:10.1155/2020/8438272.Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials. Kim DY, Hong SH, Jang SH, et al. International Journal of Environmental Research and Public Health. 2022;19(3):1244. doi:10.3390/ijerph19031244.

Is oat milk actually bad for you, or is this just another nutrition myth going viral? In this mini solo episode, I break down some of the most common claims circulating online about oat milk and oats, including concerns around blood sugar spikes, maltose, seed oils, and overall health impact. You've probably seen posts claiming that oat milk is “basically sugar,” that it causes dangerous spikes in blood glucose, or that the oils used in some brands are harmful or inflammatory. So what does the research actually say? This episode is all about cutting through misinformation and looking at the totality of evidence, rather than isolating single nutrients or fear-based claims. References: 1. Effect of Oat Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials 2. Effects of Oats (Avena sativa L.) on Inflammation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials 3. The Metabolic Effects of Oats Intake in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis 4. Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials 5. Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies 6. Reduction in saturated fat intake for cardiovascular disease 7. Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies 8. Review of human studies investigating the post-prandial blood-glucose lowering ability of oat and barley food products 9. Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials 10. Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia ____________________________________________________________________

Send us Fan MailIn this Journal Club episode, Ben and Daphna review a systematic review and meta-analysis from JAMA Network Open questioning the clinical value of predischarge car seat tolerance screening (CSTS). Driven by data suggesting that testing does not reduce 30-day mortality or hospital readmissions, they discuss the high failure rates, varying definitions of bradycardia and desaturation, and the unintended consequence of prolonged NICU stays. They also highlight the practical reality of CSTS in ensuring parents actually have an appropriate car seat at discharge. Tune in for a critical look at whether this 1991 AAP recommendation still holds up today!----Predischarge Car Seat Tolerance Screening in Preterm and At-Risk Full-Term Infants: A Systematic Review and Meta-Analysis. King BC, Dalvie N, Hay S, Jensen EA, Zupancic JAF.JAMA Netw Open. 2026 Feb 2;9(2):e2558197. doi:0.1001/jamanetworkopen.2025.58197.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Is weight gain really about willpower… or is something deeper going on? In this episode, Dr. Brendan McCarthy, Chief Medical Officer at Protea Medical Center, breaks down the real biology behind stress, cravings, and weight gain—and why blaming yourself (or cortisol) is missing the point. You'll learn: Why chronic stress rewires your metabolism How stress drives cravings for ultra-processed foods The truth about cortisol and fat storage Why “just have more discipline” is bad medicine How ultra-processed foods hijack your hunger and reward systems The key to rebuilding control and agency This isn't about motivation—it's about understanding your biology so you can finally work with your body instead of against it. If you've ever felt stuck, frustrated, or blamed for your weight… this episode is for you.   Mechanism-Anchored References     1.    Glucocorticoids, stress, and eating Kuckuck S, van der Valk ES, Scheurink AJW, et al. Glucocorticoids, stress and eating: the mediating role of appetite-regulating hormones. Obesity Reviews. 2023. Supports the claim that stress biology and glucocorticoid signaling can alter appetite regulation and eating behavior.       2.    Stress-level glucocorticoids can increase hunger Bini J, et al. Stress-level glucocorticoids increase fasting hunger and alter cerebral blood flow in neural regions that regulate food intake. 2022. Supports the claim that stress-level glucocorticoid exposure can increase hunger and affect food-intake regulation.       3.    Stress-obesity link / HPA-axis context Lengton R, et al. Glucocorticoids and HPA axis regulation in the stress-obesity link. 2024. Supports the broader claim that chronic stress and glucocorticoid biology are relevant to obesity risk and metabolic dysregulation.       4.    Sleep loss changes appetite and metabolism Van Cauter E, et al. Metabolic consequences of sleep and sleep loss. 2008. Supports the claim that inadequate sleep alters appetite regulation and harms carbohydrate metabolism.       5.    Sleep deprivation impairs glucose handling and raises appetite pressure Knutson KL. The metabolic consequences of sleep deprivation. 2007. Supports the claim that sleep loss can worsen glucose metabolism, appetite drive, and obesity risk.       6.    Circadian disruption and metabolic dysfunction Depner CM, et al. Metabolic consequences of sleep and circadian disorders. 2014. Supports the claim that circadian disruption and sleep deficiency contribute to metabolic dysregulation and weight gain risk.       7.    Ultra-processed food and reward-system activation Calcaterra V, et al. Ultra-Processed Food, Reward System and Childhood Obesity. 2023. Supports the claim that ultra-processed foods interact with reward pathways in ways that can drive intake beyond simple calorie math.       8.    Ultra-processed food and metabolic dysfunction Vitale M, et al. Ultra-Processed Foods and Human Health: A Systematic Review and Meta-Analysis. 2023. Supports the claim that higher UPF consumption is associated with obesity and metabolic disease risk.       9.    Stress and poorer diet quality / emotional eating Shatwan IM, et al. Association between perceived stress, emotional eating, and diet quality. 2024. Supports the claim that higher perceived stress is associated with worse dietary patterns and emotional eating.       10.    Compassion-based framing and adherence Sirois FM, et al. Self-Compassion and Adherence in Five Medical Samples. 2018. Supports the closing point that shame is a weak intervention model and that compassion-linked framing may better support adherence and change.     Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

Podcast family, welcome to Quickie #4. This one will be fun: A. Medicine changes, and changes fast. I trained with and learned the Grannum grading placental system (grades 0-III based on ultrasound appearance). Is that still a thing? We recently found a “grade III placenta at 34 weeks” as an incidental finding. Is there specific management considerations for this? Listen in for details. B. What do we do when a patient has “two GBS results” in one pregnancy hat are discordant. Listen in for that as well!1. Jaiman S, Romero R, Pacora P, et al. Disorders of Placental Villous Maturation Are Present in One-Third of Cases With Spontaneous Preterm Labor. Journal of Perinatal Medicine. 2021. 2. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2017. Sentilhes L, Sénat MV, Ancel PY, et al. Prevention of Spontaneous Preterm Birth: Guidelines for Clinical Practice From the French College of Gynaecologists and Obstetricians (CNGOF).3. Brink LT, Roberts DJ, Wright CA, et al. Placental Pathology in Spontaneous and Iatrogenic Preterm Birth: Different Entities With Unique Pathologic Features. Placenta. 2022. 4. Chitlange SM, Hazari KT, Joshi JV, Shah RK, Mehta AC. Ultrasonographically Observed Preterm Grade III Placenta and Perinatal Outcome.International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics. 1990. 5. Mirza FG, Ghulmiyyah LM, Tamim H, et al. To Ignore or Not to Ignore Placental Calcifications on Prenatal Ultrasound: A Systematic Review and Meta-Analysis. The Journal of Maternal-Fetal & Neonatal Medicine : The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2018. 6. Quinlan RW, Cruz AC, Buhi WC, Martin M. Changes in Placental Ultrasonic Appearance. II. Pathologic Significance of Grade III Placental Changes. American Journal of Obstetrics and Gynecology. 1982. 7. Karen M. Puopolo Group B Streptococcal Disease. https://orcid.org/0000-0002-5581-8825; Published February 25, 2026 N Engl J Med 2026;394:896-905ACOG 797

* Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study* Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction* Andrew's previous SM post on the subject: How a Meta-Analysis can Mislead—The Story of Complete vs Culprit-only PCI in STEMIAnd, a bunch of the other studies we discussed.* Complete Revascularization with Multivessel PCI for Myocardial Infarction* FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction* Initial Invasive or Conservative Strategy for Stable Coronary Disease This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Interview with Balázs Szigeti, PhD, author of Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions: A Systematic Review and Meta-Analysis. Hosted by John Torous, MD. Related Content: Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions

In this evidence-packed episode, Dr. Scott Watier and Tommy Welling dissect a December 2025 systematic review and meta-analysis from Frontiers in Nutrition examining how intermittent fasting improves metabolic syndrome outcomes compared to traditional calorie restriction. They reveal that participants with metabolic syndrome—defined as having three or more risk factors including elevated waist circumference, high triglycerides, low HDL, elevated blood pressure, and high fasting glucose—experienced significant improvements in fasting blood glucose, A1C, insulin resistance, LDL cholesterol, and inflammatory markers with high certainty of evidence when using various IF protocols. The hosts explain why smart, experienced people spend years tracking and counting calories yet feel stuck, emphasizing that intermittent fasting addresses the root drivers of metabolic dysfunction rather than just creating a caloric deficit through willpower and restriction. They demonstrate how modified alternate-day fasting showed 50-100% greater reductions in inflammatory markers over 16 weeks, and why time-restricted eating delivers faster blood sugar improvements, providing practical guidance on matching your fasting pattern to your metabolic profile while focusing on beneath-the-surface changes happening long before the scale or the world can see them. ⁠⁠⁠⁠⁠⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://pubmed.ncbi.nlm.nih.gov/41459076/

Neuraxial analgesia (epidural or spinal) combined withtocolytic therapy is the pain control method that best increases the success rate of external cephalic version (ECV), according to the ACOG's PB 221. However, some patients may be reluctant to use regional anesthesia and may askabout IV analgesia. A new study in the AJOG (released as an ePub on March 5, 2026) provides some insights that may be helpful for patient consultation. These investigators compared the success of external cephalic version, modes of delivery, maternal pain, and complications using three strategies: intravenous analgesia with remifentanil, epidural anesthesia, and a stepwise approach in which epidural anesthesia was administered only if intravenous analgesia was unsuccessful. Listen in for details.1.     ACOG PB 2212.     Aiartzaguena, Amaia et al. Comparativeeffectiveness of intravenous remifentanil, epidural anesthesia and a two-stepanalgesic approach for external cephalic version: a large prospectivesingle-center cohort study. American Journal of Obstetrics & Gynecology,Volume 0, Issue 03.     Hao Q, Hu Y, Zhang L, et a l. A SystematicReview and Meta-Analysis of Clinical Trials of Neuraxial, Intravenous, andInhalational Anesthesia for External Cephalic Version. Anesthesia andAnalgesia. 2020. 4.     Wilson MJA, MacArthur C, Hewitt CA, et al.5.     Intravenous Remifentanil Patient-ControlledAnalgesia Versus Intramuscular Pethidine for Pain Relief in Labour (RESPITE):An Open-Label, Multicentre, Randomised Controlled Trial. Lancet. 2018.

A new meta-analysis just dropped, and once again, saturated fat takes center stage. But does the data actually support the decades-long warnings we've heard about saturated fat and heart disease? Not exactly.In this video, Dr. Bret Scher dives deep into a recent study published in the Annals of Internal Medicine that reviewed randomized controlled trials on saturated fat intake and health outcomes.Despite the headlines and abstract language hinting at risk, a closer look at the data reveals no statistically significant increase in heart attacks, strokes, or early death, even with modest increases in LDL.So why the disconnect between what the data shows and what the authors claim? Dr. Scher breaks it down and explores the nuances often missing from the conversation about saturated fat, including context like food quality, carbohydrate intake, metabolic health, and lifestyle factors that make a big difference.

In this episode, hosts Eric Trexler and Eric Helms explore a wide range of topics including the culture of bodybuilding, the impact of step counts on health, protein intake nuances, and the effects of various performance-enhancing drugs. They also address common misconceptions and recent research findings, providing practical insights for fitness enthusiasts and professionals alike. Be sure to support us (and our friends!) by using code "MRR10" for 10% off your order at elitefts.com Chapters 00:00 Intro 05:26 Who can claim to be a "Bodybuilder" 14:35 Protein Intake and Muscle Protein Synthesis 25:39 Soy Intake and Its Effects on Hormones 31:10 Step count "limits" 39:44 Clarification related to soy intake 44:32 Trex research updates & Constrained Energy Expenditure Model 56:50 Exercise energy compensation: natural vs enhanced lifters 01:04:52 Hypertrophy and Proximity to Failure: Insights from Meta-Analysis

EVOLUT Low Risk data, a provocative meta-analysis, DNR orders, targeted hypothermia, good news in HFpEF evidence, and GLP-1s as AF drugs are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I EVOLUT Low Risk 6-year Results and a 5-year Meta-Analysis of TAVR vs SAVR 6-Year Outcomes of TAVR vs SAVR https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063 EVOLUT Low Risk Trial at 2 years https://www.nejm.org/doi/full/10.1056/NEJMoa1816885 EVOLUT Low Risk Trial at 3 years https://www.jacc.org/doi/10.1016/j.jacc.2023.02.017 EVOLUT Low Risk Trial at 4 years https://www.jacc.org/doi/10.1016/j.jacc.2023.09.813 Nonproportional Hazards for Time-to-Event Outcomes in Clinical Trials https://www.jacc.org/doi/10.1016/j.jacc.2019.08.1034 TAVR vs SAVR 5-Year Outcomes - Systematic Review https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092 TAVR vs SAVR Updated Meta-Analysis of RCTs https://www.jacc.org/doi/10.1016/j.jacc.2024.12.031 UK TAVI Trial https://jamanetwork.com/journals/jama/fullarticle/2792251 Dr David Cohen on X https://x.com/djc795/status/2023556582030852172?s=46&t=zXMCUoVjSsdyemzWlzeBjA II DNR in the Hospital Inadequate Documentation of Unilateral DNR Orders https://jamanetwork.com/journals/jama/fullarticle/2829203 GeriPal Blog Unilateral DNR Orders https://geripal.org/unilateral-dnr-gina-piscitello-erin-demartino-will-parker/ III Yet another failure of Targeted Hypothermia 2-Year Follow-Up of TTM2 Trial https://jamanetwork.com/journals/jamaneurology/fullarticle/2845193 TTM2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2100591 IV Good news in HFpEF Evidence ALT-FLOW II Trial https://doi.org/10.1093/ejhf/xuaf016 V GLP-1 as AF drugs Semaglutide as Adjunctive Therapy in Obesity-Related PAF https://doi.org/10.1093/europace/euag018 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net