Podcast appearances and mentions of meta analysis

What should you actually do when you're chronically sleep deprived?If you're a parent, shift worker, insomniac, or coach people who are, you've probably asked yourself whether training is helping or harming you.In this episode, I dive into the research on acute and chronic sleep restriction and its effects on:• Cognitive performance• Strength and endurance• Hormonal signalling (testosterone, AMPK, mTOR)• Mood and perceived health• Recovery and long-term adaptationWe examine a 2025 systematic review and meta-analysis of 45 experimental studies (from 18,127 initially identified papers) looking at sleep deprivation and performance. We unpack one of the longest chronic sleep restriction protocols to date (6 weeks of restricted weekday sleep with weekend “recovery”), and what that tells us about cumulative sleep debt.We also explore:• Why early waking may impair cognition differently than going to bed late• Whether moderate aerobic exercise can offset some cognitive effects of sleep loss• What experimental data show about testosterone under sleep restriction• Why resistance training under chronic sleep deprivation may require adjustment• The difference between narrative reviews and higher-quality meta-analytic evidenceEssentially, we look at how to train intelligently when sleep is broken, short, or unpredictable, and what the science can (and cannot) tell us right now.Main ReferenceSystematic Review & Performance Effects[2025 Systematic Review & Meta-Analysis on Sleep Deprivation and Performance – 45 Experimental Studies]Chronic Sleep Restriction with Weekend RecoverySmith et al. (2021). Chronic sleep restriction during a 6-week protocol with weekend recovery and cumulative sleep debt analysis.

In this episode, hosts Eric Trexler and Eric Helms explore a wide range of topics including the culture of bodybuilding, the impact of step counts on health, protein intake nuances, and the effects of various performance-enhancing drugs. They also address common misconceptions and recent research findings, providing practical insights for fitness enthusiasts and professionals alike. Be sure to support us (and our friends!) by using code "MRR10" for 10% off your order at elitefts.com Chapters 00:00 Intro 05:26 Who can claim to be a "Bodybuilder" 14:35 Protein Intake and Muscle Protein Synthesis 25:39 Soy Intake and Its Effects on Hormones 31:10 Step count "limits" 39:44 Clarification related to soy intake 44:32 Trex research updates & Constrained Energy Expenditure Model 56:50 Exercise energy compensation: natural vs enhanced lifters 01:04:52 Hypertrophy and Proximity to Failure: Insights from Meta-Analysis

This issue will review: 1.     Real-World Prospective Validation and Economic Evaluation of Deep Learning-based Diabetic Retinopathy Detection from Fundus Photographs: A Systematic Review and Meta- Analysis 2.     Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial 3.     FDA removal of SI for GLP-1s – FDA Announcement Neil Read/John Comment 4.     Effectiveness and Safety of Statins in Type 2 Diabetes According to Baseline Cardiovascular Risk: A Target Trial Emulation Study 5.     GLP-1 Receptor Agonists and Risk of Optic Nerve or Vision-Threatening Events in Patients with Type 2 Diabetes or Cardiometabolic Diseases: A Meta-Analysis of Randomized Controlled Trials  Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update   discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. For more information about each of ADA's science and medical journals, please visit Diabetesjournals.org. Hosts: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health

Reflections on the Peter Attia/Epstein scandal; How to lower lp(a)—does diet help? What are bio-active peptides? Could they stave off kidney disease? Scientists just tested the fittest 81-year-old in the world—here's what they found; Media erroneously report that intermittent fasting is not effective for weight loss; Sugary drinks may stoke anxiety in teens; Omega-3s support kids' reading fluency and spelling scores; Surprising study shows saturated fats not harmful to kidneys.

EVOLUT Low Risk data, a provocative meta-analysis, DNR orders, targeted hypothermia, good news in HFpEF evidence, and GLP-1s as AF drugs are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I EVOLUT Low Risk 6-year Results and a 5-year Meta-Analysis of TAVR vs SAVR 6-Year Outcomes of TAVR vs SAVR https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063 EVOLUT Low Risk Trial at 2 years https://www.nejm.org/doi/full/10.1056/NEJMoa1816885 EVOLUT Low Risk Trial at 3 years https://www.jacc.org/doi/10.1016/j.jacc.2023.02.017 EVOLUT Low Risk Trial at 4 years https://www.jacc.org/doi/10.1016/j.jacc.2023.09.813 Nonproportional Hazards for Time-to-Event Outcomes in Clinical Trials https://www.jacc.org/doi/10.1016/j.jacc.2019.08.1034 TAVR vs SAVR 5-Year Outcomes - Systematic Review https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092 TAVR vs SAVR Updated Meta-Analysis of RCTs https://www.jacc.org/doi/10.1016/j.jacc.2024.12.031 UK TAVI Trial https://jamanetwork.com/journals/jama/fullarticle/2792251 Dr David Cohen on X https://x.com/djc795/status/2023556582030852172?s=46&t=zXMCUoVjSsdyemzWlzeBjA II DNR in the Hospital Inadequate Documentation of Unilateral DNR Orders https://jamanetwork.com/journals/jama/fullarticle/2829203 GeriPal Blog Unilateral DNR Orders https://geripal.org/unilateral-dnr-gina-piscitello-erin-demartino-will-parker/ III Yet another failure of Targeted Hypothermia 2-Year Follow-Up of TTM2 Trial https://jamanetwork.com/journals/jamaneurology/fullarticle/2845193 TTM2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2100591 IV Good news in HFpEF Evidence ALT-FLOW II Trial https://doi.org/10.1093/ejhf/xuaf016 V GLP-1 as AF drugs Semaglutide as Adjunctive Therapy in Obesity-Related PAF https://doi.org/10.1093/europace/euag018 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

In this episode of One in Ten, host Teresa Huizar welcomes Dr. Brian Allen, professor in the Department of Pediatrics at Penn State, to discuss what motivates problematic sexual behavior (PSB) in children and youth and what the research shows. Allen explains his path into the field and why he conducted a meta-analysis—combining results across studies to create a much larger dataset (about 9,000 children) and examine the strength of associations across age, gender, and different risk factors.Time Stamps Time Topic 00:00 What Drives Problematic Sexual Behavior (PSB) in Kids? (Episode Intro) 01:15 Meet Dr. Brian Allen + How He Got Into PSB Research 02:54 Meta-Analysis 101: What It Is and Why It Matters for PSB 05:26 Beyond the Assumption: Is PSB Always Linked to Sexual Abuse? 07:24 Who's Affected? Gender & Age Patterns in the Data 08:41 Age Matters: Developmental Motivations, Curiosity & Online Exposure 14:01 Why Parents Struggle to Talk About Sex, Boundaries & Prevention 16:44 What the Meta-Analysis Found: PSB's Link to Sexual Abuse (and How to Ask) 19:00 Physical Abuse, Dysregulation & Coercion: A Surprising Strong Correlate 25:35 Screening & Mental Health: Externalizing vs Internalizing Problems 29:01 Big Research Gaps: Cross-Cultural Data, Developmental Pathways & Social Media 32:12 What's Next: New Assessment Tool, Longitudinal Studies & Treatment Trials 33:38 Key Takeaways for Clinicians: Treatable, Low Risk, Don't Go Punitive 36:22 Reframing These Kids + Resources, Training, and Closing 39:10 Final Thanks & Where to Learn More ResourcesProblematic Sexual Behavior Among Children: A Meta-Analysis of Demographic and Clinical Correlates | Research on Child and Adolescent Psychopathology | Springer Nature LinkSupport the showDid you like this episode? Please leave us a review on Apple Podcasts.

Send a textIn episode #174 we discussed Dr. Jose Areta's latest research, including:How energy deficits influence muscle protein synthesis and qualityThe role of mitochondrial proteins and their upregulation during energy restrictionPractical implications for timing and periodization of caloric deficits in training cyclesHormonal signals and their interaction with muscle adaptation during energy deficitsAssociate Professor Dr. José L. Areta is a leading scholar in Exercise Metabolism and Nutrition in the School of Sport and Exercise Sciences at Liverpool John Moores University (LJMU). His research investigates how nutrition and exercise interact to influence both performance and health. He focuses on the timing and composition of macronutrients — carbohydrates, proteins, and fats — and how they affect training adaptation. José also examines the role of dietary supplements in optimizing athletic performance, as well as the endocrine and metabolic consequences of energy restriction, particularly low energy availability. He has contributed influential studies on how severe calorie deficits combined with exercise can alter muscle quality and metabolism. José's work links cellular-level changes in muscle to practical nutrition strategies for athletes facing weight-sensitive sports or energy restriction.Please note that this podcast is created strictly for educational purposes and should never be used for medical diagnosis or treatment.Follow Jose Areta's research: Study discussed, Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit With Concomitant Aerobic Exercise in Humans: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502384RRIG: https://www.instagram.com/jose_l_aretaWeb: https://profiles.ljmu.ac.uk/13460-jose-aretaResearch: https://scholar.google.com/citations?user=8tP0vzUAAAAJ&hl=enMentioned:A Systematic Review and Meta-Analysis on the Association and Differences between Aerobic Threshold and Pint of Optimal Fat OxidationCreatineBeta-alanineMORE NR Save 10% on our website with code NEWPOD10 Apply to work with us, click here: https://nutritional-revolution.com/ Interested in having your biomarkers or nutrigenomics checked? Email us at nutritionalrev@gmail.com Follow us @nutritionalrevolution Save 20% on supplements at our trusted online source: https://us.fullscript.com/welcome/kchannell Join Nutritional Revolution's The Feed Club to get $20 off with an additional $20 Feed credit drop every 90 days.: https://thefeed.com/teams/nutritional-revolution If you're interested in sponsoring Nutritional Revolution Podcast, shoot us an email at nutritionalrev@gmail.com.

In this episode of The Counseling Psychologist podcast series, Ms. Sally Ye Jin Lee talks about the article recently published in TCP titled, "What is Humility Good For? A Meta-Analysis of Humility, Health, and Well-Being."

This week’s Pulm PEEPs Pearls episode is all about spontaneous breathing trials (SBTs). SBTs are a standard part of the daily practice in the intensive care unit, but the exact methods vary across ICUs and institutions. Listen in to hear about the most common methods of SBTs, the physiology of each method, and what the evidence says. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points What an SBT is really testing An SBT is a stress test for post-extubation work of breathing, not just a ventilator check. The goal is to balance sensitivity and specificity: Too hard → unnecessary failures and delayed extubation Too easy → false positives and higher risk of reintubation Common SBT modalities and how they compare T-piece No inspiratory support and no PEEP Highest work of breathing Most “physiologic” but often too strict Pressure support (PS) + PEEP (e.g., 5/5 or 8/5) Offsets ETT resistance and provides modest assistance Easier to pass than T-piece CPAP (0/5) No inspiratory help, but provides PEEP to counter ETT resistance Sits between PS and T-piece in difficulty Evidence favors pressure-supported SBTs for most patients Large meta-analysis (~6,000 patients, >40 RCTs): Pressure-supported SBTs increase successful extubation (~7% absolute benefit) No increase in reintubation rates Trials (e.g., FAST trial): Patients pass SBTs earlier Leads to earlier extubation and fewer ventilator-associated risks Bottom line: A 30-minute PS 5/5 SBT is evidence-based and appropriate for most stable ICU patients When a T-piece still makes sense T-piece SBTs are useful when: Cost of reintubation is high Difficult airway Prior failed extubation Pretest probability of success is low Prolonged or difficult weaning Tracheostomy vs extubation decisions Need to mimic physiology without positive pressure In LV dysfunction or pulmonary edema even small amounts PEEP may significantly improve physiology Some centers use a hybrid approach: PS SBT → short confirmatory T-piece before extubation CPAP as a middle ground Rationale: Allows full patient effort while compensating for ETT resistance Evidence: Fewer and smaller trials Possible modest improvement in extubation success No clear mortality or LOS benefit Reasonable option based on patient physiology, institutional protocols, and clinician comfort No single “perfect” SBT mode Across PS, T-piece, CPAP, and newer methods (e.g., high-flow via ETT) there are no consistent differences in mortality or length of stay What matters most: Daily protocolized screening Thoughtful bedside clinical judgment Matching SBT difficulty to patient-specific risk Institutional variation is normal—and acceptable Examples: PS 10/5 in postoperative surgical ICU patients PS 5/0 as an intermediate difficulty option Key question clinicians should ask: What does passing or failing this specific SBT tell me about this patient's likelihood of post-extubation success? Take-home pearls SBTs are stress tests of post-extubation physiology. PS 5/5 for 30 minutes is a strong default for most ICU patients. T-piece trials are valuable when false positives are costly or physiology demands it. CPAP is reasonable but supported by less robust data. Consistency, daily screening, and judgment matter more than the exact mode. References and Further Reading Burns KEA, Khan J, Phoophiboon V, Trivedi V, Gomez-Builes JC, Giammarioli B, Lewis K, Chaudhuri D, Desai K, Friedrich JO. Spontaneous Breathing Trial Techniques for Extubating Adults and Children Who Are Critically Ill: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2024 Feb 5;7(2):e2356794. doi: 10.1001/jamanetworkopen.2023.56794. PMID: 38393729; PMCID: PMC10891471. Burns KEA, Sadeghirad B, Ghadimi M, Khan J, Phoophiboon V, Trivedi V, Gomez Builes C, Giammarioli B, Lewis K, Chaudhuri D, Desai K, Friedrich JO. Comparative effectiveness of alternative spontaneous breathing trial techniques: a systematic review and network meta-analysis of randomized trials. Crit Care. 2024 Jun 8;28(1):194. doi: 10.1186/s13054-024-04958-4. PMID: 38849936; PMCID: PMC11162018. Subirà C, Hernández G, Vázquez A, Rodríguez-García R, González-Castro A, García C, Rubio O, Ventura L, López A, de la Torre MC, Keough E, Arauzo V, Hermosa C, Sánchez C, Tizón A, Tenza E, Laborda C, Cabañes S, Lacueva V, Del Mar Fernández M, Arnau A, Fernández R. Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial. JAMA. 2019 Jun 11;321(22):2175-2182. doi: 10.1001/jama.2019.7234. Erratum in: JAMA. 2019 Aug 20;322(7):696. doi: 10.1001/jama.2019.11119. PMID: 31184740; PMCID: PMC6563557. Burns KEA, Wong J, Rizvi L, Lafreniere-Roula M, Thorpe K, Devlin JW, Cook DJ, Seely A, Dodek PM, Tanios M, Piraino T, Gouskos A, Kiedrowski KC, Kay P, Mitchell S, Merner GW, Mayette M, D’Aragon F, Lamontagne F, Rochwerg B, Turgeon A, Sia YT, Charbonney E, Aslanian P, Criner GJ, Hyzy RC, Beitler JR, Kassis EB, Kutsogiannis DJ, Meade MO, Liebler J, Iyer-Kumar S, Tsang J, Cirone R, Shanholtz C, Hill NS; Canadian Critical Care Trials Group. Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial. JAMA. 2024 Dec 3;332(21):1808-1821. doi: 10.1001/jama.2024.20631. PMID: 39382222; PMCID: PMC11581551. Mahul M, Jung B, Galia F, Molinari N, de Jong A, Coisel Y, Vaschetto R, Matecki S, Chanques G, Brochard L, Jaber S. Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients. Crit Care. 2016 Oct 27;20(1):346. doi: 10.1186/s13054-016-1457-4. PMID: 27784322; PMCID: PMC5081985. Yi LJ, Tian X, Chen M, Lei JM, Xiao N, Jiménez-Herrera MF. Comparative Efficacy and Safety of Four Different Spontaneous Breathing Trials for Weaning From Mechanical Ventilation: A Systematic Review and Network Meta-Analysis. Front Med (Lausanne). 2021 Nov 22;8:731196. doi: 10.3389/fmed.2021.731196. PMID: 34881255; PMCID: PMC8647911.​

In this episode host, Erin Gallardo, PT, DPT, NCS speaks with Chris McElderry, PT, DPT, NCS about how dry needling can be used in neuro rehab, particularly for people post-stroke. Chris explains why he pursued dry needling, how using it in PT differs from acupuncture, and walks through what a typical session looks like, including safety, side effects, and billing considerations. He shares clinical examples of using dry needling to address spasticity, hypertonicity, pain, and range of motion limitations, and discusses current research on short-term effects for spasticity and pain reduction. Erin and Chris also clarify the differences between spasticity and hypertonicity, touch on contracture management, and highlight where dry needling can be a useful adjunct—not a standalone cure—in helping neuro clients move and feel better. Follow Chris McElderry, PT, DPT, NCS @theneuroguy_dpt  Ebrahimzadeh M, Nakhostin Ansari N, Abdollahi I, Akhbari B, Dommerholt J. Changes in Corticospinal Tract Consistency after Dry Needling in a Stroke Patient. Case Rep Neurol Med. 2024 Sep 14;2024:5115313. doi: 10.1155/2024/5115313. PMID: 39309410; PMCID: PMC11416164. Fakhari Z, Ansari NN, Naghdi S, Mansouri K, Radinmehr H. A single group, pretest-posttest clinical trial for the effects of dry needling on wrist flexors spasticity after stroke. NeuroRehabilitation. 2017;40(3):325-336. doi: 10.3233/NRE-161420. PMID: 28222554. Fernández-de-Las-Peñas C, Pérez-Bellmunt A, Llurda-Almuzara L, Plaza-Manzano G, De-la-Llave-Rincón AI, Navarro-Santana MJ. Is Dry Needling Effective for the Management of Spasticity, Pain, and Motor Function in Post-Stroke Patients? A Systematic Review and Meta-Analysis. Pain Med. 2021 Feb 4;22(1):131-141. doi: 10.1093/pm/pnaa392. PMID: 33338222. Núñez-Cortés R, Cruz-Montecinos C, Vásquez-Rosales P, et al. Effectiveness of dry needling in the treatment of spasticity in stroke patients: A systematic review. J Body Mov Ther. 2020;24(3):113-122. Suputtitada A, et al. Emerging theory of sensitization in post-stroke muscle spasticity: Implications for dry needling and other interventions. Front Rehabil Sci. 2023;4:1169087. Valencia-Chulián R, Heredia-Rizo AM, Moral-Munoz JA, Lucena-Anton D, Luque-Moreno C. Dry needling for the management of spasticity, pain, and range of movement in adults after stroke: A systematic review. Complement Ther Med. 2020 Aug;52:102515. doi: 10.1016/j.ctim.2020.102515. Epub 2020 Jul 16. PMID: 32951759.

Send us a textEstamos quase chegando no Carnaval, por isso esse episódio traz a diversificação do desfile de uma escola de samba. Vem com a gente atravessar essa Sapucaí de conhecimento!1.     Hepatitis B Vaccination at Birth: Safety, Effectiveness, and Public Health Benefit - https://pubmed.ncbi.nlm.nih.gov/41639943/2.     Desaturations with or without Bradycardia are Associated with Cerebral and Abdominal Hypoxemia: Secondary Analysis of a Randomized Clinical Trial - https://pubmed.ncbi.nlm.nih.gov/41615858/3.     American Academy of Pediatrics 2022 phototherapy thresholds reduce the hospitalizations and the associated costs - https://pubmed.ncbi.nlm.nih.gov/41591975/4.     Clinical Signs Associated With Mortality and Sepsis in Young Infants A Systematic Review and Meta-Analysis - https://jamanetwork.com/journals/jamapediatrics/article-abstract/2844622 Não esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Lembrando que o Podcast está no Instagram, @incubadora.podcast, onde a gente posta as figuras e tabelas de alguns artigos. Se estiver gostando do nosso Podcast, por favor dedique um pouquinho do seu tempo para deixar sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. Isso é importante para a gente poder continuar produzindo os episódios. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org

Send us a textDie Wahl des Hypnotikums zur Notfallintubation kritisch kranker Patient:innen ist seit Jahren Gegenstand intensiver Diskussionen. In dieser Episode analysieren wir die RSI-Studie aus dem New England Journal of Medicine, die Ketamin und Etomidat hinsichtlich Mortalität und kardiovaskulärer Komplikationen während der Intubation systematisch vergleicht.Casey JD, Seitz KP, Driver BE, et al.; for the RSI Investigators and the Pragmatic Critical Care Research Group.Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults.New England Journal of Medicine. Published online December 9, 2025.DOI: 10.1056/NEJMoa2511420Die tracheale Intubation kritisch kranker Patient:innen ist mit einer hohen Morbidität und Mortalität assoziiert. Während Etomidat aufgrund seiner hämodynamischen Stabilität eingesetzt wird, bestehen seit Langem Bedenken hinsichtlich einer durch Etomidat induzierten Suppression der Nebennierenfunktion und möglicher negativer Effekte auf das Überleben. Ketamin gilt als Alternative, da es die Kortisolproduktion nicht hemmt, jedoch ebenfalls potenziell hämodynamische Nebenwirkungen aufweist.In einer pragmatischen, multizentrischen, randomisierten Studie wurden 2365 kritisch kranke Erwachsene in 14 Notaufnahmen und Intensivstationen in den USA entweder Ketamin oder Etomidat zur Narkoseeinleitung bei der endotrachealen Intubation zugeteilt. Der primäre Endpunkt war die Gesamtmortalität im Krankenhaus bis Tag 28. Als sekundärer Endpunkt wurde ein kardiovaskulärer Kollaps während der Intubation definiert, bestehend aus schwerer Hypotonie, neuem oder eskaliertem Vasopressorbedarf oder Herzstillstand.Die 28-Tage-Mortalität unterschied sich nicht signifikant zwischen den Gruppen (28,1 % unter Ketamin vs. 29,1 % unter Etomidat). Dieses Ergebnis war konsistent über alle präspezifizierten Subgruppen hinweg, einschließlich Patient:innen mit Sepsis oder septischem Schock, hoher Krankheitslast (APACHE-II-Score ≥ 20) sowie präinterventioneller Vasopressortherapie. Im Gegensatz dazu trat ein kardiovaskulärer Kollaps während der Intubation unter Ketamin signifikant häufiger auf als unter Etomidat, insbesondere bei Patient:innen mit Sepsis oder hoher Erkrankungsschwere.Die Ergebnisse der RSI-Studie zeigen, dass Ketamin im Vergleich zu Etomidat keine Reduktion der kurzzeitigen Mortalität bewirkt, jedoch mit einem erhöhten Risiko hämodynamischer Instabilität während der Intubation einhergeht. Damit liefern die Daten eine wichtige evidenzbasierte Grundlage für die individualisierte Auswahl des Induktionshypnotikums bei kritisch kranken Patient:innen.Weiterführende Literatur:1. Ketamine Versus Etomidate for Rapid Sequence Intubation: A Systematic Review and Meta-Analysis of Randomized Trials. Critical Care Medicine. 2025. Greer A, Hewitt M, Khazaneh PT, et al.2. Readdressing Rapid Sequence Induction and Intubation Using Ketamine or Etomidate: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Medicine. 2025. de Morais LB, Radel-Neto GR, Dos Santos Valsecchi VA, Costa RA, Hueb W.3. Ketamine Versus Etomidate as an Induction Agent for Tracheal Intubation in Critically Ill Adults: A Bayesian Meta-Analysis.Critical Care. 2024. Koroki T, Kotani Y, Yaguchi T, et al.4. Society of Critical Care Medicine Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient. Critical Care Medicine. 2023. Acquisto NM, Mosier JM, Bittner EA, et al.

Heath recounts his experience at the War on the Shore 2026.0:00 - Intro2:30 - New Space Marine Detachments28:04 - Metawatch37:48 - War on the Shore41:54 - Heath's List47:01 - Rd 1 vs Eldar52:39 - Rd 2 vs World Eaters1:04:57 - Rd 3 vs Tau1:09:49 - Rd 4 vs Custodes1:13:33 - Rd 5 vs Dark Angels1:21:01 - Hobby Challenge1:23:16 - Community Comments1:24:17 - OutroIf you want to learn more about Dank Lists Wargaming then follow us on our social medias listed below and subscribe here:Email: danklistswargaming@gmail.comFacebook: https://www.facebook.com/danklists/Instagram: https://www.instagram.com/danklistswargaming/Twitch: https://www.twitch.tv/danklistswargamingTwitter: https://twitter.com/DankListsWebsite: https://danklistswargaming.wixsite.com/danklistsMDF Terrain by Laser Craft Workshop: https://lasercraftworkshop.com/Video made using Da Vinci 20.Credit: "Music: https://www.purple-planet.com'For written Meta Analysis, please visit: https://40kangelskeep.blogspot.com/

Back in March of 2025, the green journal (obstetrics andgynecology) published A systematic review and meta-analysis on 2 medications (non-hormonal) and their efficacy in menopausal hot flash relief period these medications were Fezolinetant and Elinzanetant. However, the editors have just recently released an “Expression of Concern” about this review. Listen in for details. 1.     Menegaz de Almeida, Artur MS; Oliveira, PalomaMS; Lopes, Lucca MD; Leite, Marianna MS; Morbach, Victória MS; Alves Kelly,Francinny MD; Barros, Ítalo MS; Aquino de Moraes, Francisco Cezar MS;Prevedello, Alexandra MD. Fezolinetant and Elinzanetant Therapy for MenopausalWomen Experiencing Vasomotor Symptoms: A Systematic Review and Meta-analysis.Obstetrics & Gynecology 145(3):p 253-261, March 2025. | DOI:10.1097/AOG.00000000000058122.     Expression of Concern: Fezolinetant andElinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: ASystematic Review and Meta-Analysis. Obstetrics & Gynecology():10.1097/AOG.0000000000006180, January 16, 2026. | DOI: 10.1097/AOG.0000000000006180

Meta-analyses are powerful tools, but they can be challenging to interpret. In this episode, we explore how dysphagia clinicians can better understand and critically evaluate meta-analyses to support evidence-informed practice. We are joined by Prof. Kendrea Garand to talk about the article “How to Interpret and Evaluate a Meta-Analysis in the Field of Speech and Language Therapy: A Tutorial for Clinicians.” We discuss: What meta-analyses are and why they matter for dysphagia clinicians How to conduct a meta-analysis How to critically interpret and evaluate a meta-analysis Red flags in pooling studies in meta-analyses Rapid appraisal tips for clinical decision-making Integrating evidence with clinical expertise and patient values

Quadriceps shutdown after ACL reconstruction is one of the biggest barriers we see in the clinic. Even with modern surgical techniques and “aggressive” rehab, too many athletes struggle to get their quad strength back, and that deficit shows up later in gait, loading, and confidence on the field.A new systematic review and meta-analysis just took a fresh look at neuromuscular electrical stimulation (NMES) as an adjunct to ACL rehab. Does adding NMES actually move the needle on quad strength? Does timing matter? And does any of this translate into better knee function where it counts?In this week's podcast, we break down what the authors found, how strong the evidence really is, and how we're thinking about NMES programming in our own ACL protocols. If you're working with post-op knees, you'll want to hear this before you set up your next rehab plan.To see full show notes and more, head to: https://mikereinold.com/should-every-acl-get-e-stim-what-the-new-nmes-meta-analysis-really-shows/Join us on Tuesday night, February 3rd, at 8:00 PM EST to celebrate the 10-year anniversary of our podcast! We'll be recording an episode where you can ask us questions live, plus special discounts on our courses, and over $2500 in free giveaways from Ancore, SmartCuffs, Suji, mTrigger, and Sport Grips!Click here to register for the event - spaces are limited Click Here to View My Online CoursesWant to learn more from me? I have a variety of online courses on my website!Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the show_____Want to learn more? Check out my blog, podcasts, and online coursesFollow me: Instagram | Twitter | Facebook | Youtube

We break down the Bills' firing of Sean McDermott after their loss to the Broncos, analyze the hire of John Harbaugh to the Giants, and preview the Championship Sunday matchups: Patriots vs. Broncos and Rams vs. Seahawks. Plus, was that the best throw of Caleb Williams' life?—In this episode:The McDermott Firing & Coaching Carousel: We analyze the Bills' decision to move on from Sean McDermott, the hiring of John Harbaugh by the Giants, and Kevin Stefanski landing in Atlanta.Playoff Recap & Controversy: We break down the controversial finish to the Bills-Broncos game, the “meta” flip that doomed Buffalo's roster construction, and Caleb Williams' insane throw in the Bears' loss.The CJ Stroud Dilemma: We discuss the Texans' offensive collapse against New England and debate whether Houston is stuck in “quarterback purgatory” regarding Stroud's next contract.AFC Championship Preview (Patriots vs. Broncos): We look at how the Patriots can attack Denver's pass rush and how the Broncos will adjust with Jared Stidham stepping in for the injured Bo Nix.NFC Championship Preview (Rams vs. Seahawks): We preview the Round 3 matchup between Seattle and LA, focusing on the Stafford vs. Darnold quarterback battle and the Jaxon Smith-Njigba X-factor.—Timestamps:» Part I: The Coaching Carousel & Front Office00:00 The Bills Clean House Discussion on the firing of Sean McDermott and the promotion of GM Brandon Beane.00:47 Roster vs. The Meta Analysis of how the Bills built a roster to beat the Chiefs/Bengals but failed to adjust to the league-wide shift toward 12 personnel.05:43 The “Intellectual” Defensive Coach: A look at candidates like Brian Daboll and the trend toward hiring “intellectual” defensive minds similar to Mike Macdonald and Brandon Staley.07:53 Stefanski to Atlanta Breakdown of the potential fit for Kevin Stefanski with the Falcons' offensive weapons (Bijan Robinson, Drake London).10:38 Ulbrich & The Wide-9 Shift: Why keeping Jeff Ulbrich signals a commitment to the Wide-9/Quarters-heavy defensive structures popularized by the Saleh tree.12:50 The Harbaugh Clause: John Harbaugh to the Giants, and the unique contract clause stating he answers only to the owner.» Part II: Schematic Analysis & Game Recaps21:03 Gap Schemes vs. Speed: How the Bills utilized Pin-Pull concepts to exploit Denver's speed, noting Denver's 20th rank against Duo runs.22:33 Motion to Disrupt Coverage Denver used motion on 75% of plays (a season-high) to force communication checks and disrupt Buffalo's split-field rotations.24:22 Erasing the Deep Ball Denver's secondary held Josh Allen to 0-for-6 passing with 2 INTs on attempts of 20+ yards.27:03 Texans Offensive Collaps:e A breakdown of C.J. Stroud's struggles and the Texans' inability to counter the Patriots' game plan.30:08 Patriots MOFO Spike The Patriots increased their Middle of Field Open (MOFO) usage to 60%, using weak rotation vs. 3x1 and split-field vs. 2x2 to eliminate crossing routes.» Part III: Previews & Adjustments32:59 Patriots vs. Broncos Preview: The matchup of the Patriots' Man-Blocking/Duo schemes against the Broncos' fast-flow defense.40:35 The Caleb Williams Throw Reaction to the 45-yard cross-body throw from Caleb Williams in the Rams-Bears game.46:02 Pressure vs. Condensed Sets Dennis Allen's adjustment to blitz the edges and use DB pressure specifically against 12/13 personnel condensed formations, forcing the Rams into spread looks.» Part IV: NFC Championship Preview48:41 #1 Offense vs. #1 Defense Setting the stage for the Rams (Outside Zone) vs. Seahawks (Wide-9/Cover 2).50:00 The Schematic Conflict The clash between the Rams' outside run game and the Seahawks' defensive front is designed to force runs inside.51:27 The Cover 2 Weakness Identifying the Seahawks' 16th-ranked DVOA vs. Tight Ends as the key area for Stafford to attack the interior of the Cover 2.55:53 The JSN Factor: Why Jaxon Smith-Njigba is the X-factor for breaking down zone coverages in this matchup.—» Join Felix and Cody each Wednesday as we dive deep into the game we love!MatchQuarters is a reader-supported publication. So, make sure to subscribe.—© 2025 MatchQuarters | Cody Alexander | All rights reserved. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.matchquarters.com/subscribe

Episode 100 is a milestone moment for Business of Drinks — and instead of looking backward, we're doing what this show has always done best: Looking ahead.In this special episode, Erica Duecy, Scott Rosenbaum, and Caroline Lamb break down the biggest drinks trends shaping 2026, using a meta-analysis of 16 leading industry trend reports. The goal isn't hype, it's pattern recognition. We're pressure-testing what's structural, what's actionable, and what actually matters for founders, operators, and drinks leaders navigating a complex market.Across the first 100 episodes, one pattern has held true: Trends only matter if they translate into execution. This conversation applies that lens to what's coming next.Here's a preview of what's to come:

Dr. Peter Rippey covers the No. 10 article of 2024, titled “Effect of Extracorporeal Shockwave Therapy for Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis,” which was originally published in BMC Musculoskeletal Disorders in May 2024. Dr. Jeremy Schroeder serves as the series host. Dr. Rippey is a member of the Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2024, as selected for the 2025 AMSSM Annual Meeting. Effect of Extracorporeal Shockwave Therapy for Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis: https://link.springer.com/article/10.1186/s12891-024-07445-7

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. Michael Lanuti, Director of Thoracic Oncology in the Division of Thoracic Surgery at Massachusetts General Hospital and an Associate Professor at Harvard Medical School, and thoracic surgeon and CTSNet Senior Editor Leanne Ashrafian about Dr. Lanuti's thoughts on the JCOG0802 trial and how he believes the wrong parameters were measured. Chapters 00:00 Intro 01:52 JANS 1, ESTS Guidelines 05:09 JANS 2, Resident-Led Operating 06:57 JANS 3, Fasting Impact on Pulm Aspiration 10:02 JANS 4, What Does a Dr Look Like 12:00 Video 1, Robotic Resection & Reconstruction 13:31 Video 2, Neonatal Off-Pump Shunt DORV 15:11 Video 3, Min Inv Bi-IMA OPCAB 16:12 Dr. Lanuti, JCOG0802 Results 44:58 Upcoming Events 45:38 Instructional Video Competition 45:49 Career Center They discussed local recurrence rates, pulmonary function, and the subtypes of adenocarcinoma. Additionally, they explored how to apply these results to future patients, central and peripheral lesions, and other randomized trials. They also covered the five-year results of the JCOG0802 trial and future studies and the implications for future studies, focusing on the parameters that should be considered. Furthermore, they addressed pulmonary function tests and wedge resection.   Joel also highlights recent JANS articles on European Respiratory Society and European Society of Thoracic Surgeons clinical practice guideline on fitness for curative intent treatment of lung cancer, a 10-year propensity-matched analysis on the impact of resident-led operating on outcomes in adult cardiac surgery, a systematic review and meta-analysis on no association between preprocedural fasting and witnessed pulmonary aspiration, and asking AI what a doctor looks like.  In addition, Joel explores robotic anterolateral approach for left secondary carinal tumor resection and reconstruction, neonatal Blalock-Taussig-Thomas shunt for double outlet right ventricle with RVOTO, and minimally invasive Bi-IMA OPCAB via left thoracotomy. Before closing, Joel highlights upcoming events in CT surgery.    JANS Items Mentioned  1.) European Respiratory Society and European Society of Thoracic Surgeons Clinical Practice Guideline on Fitness for Curative Intent Treatment of Lung Cancer  2.) Impact of Resident-Led Operating on Outcomes in Adult Cardiac Surgery: A 10-Year Propensity-Matched Analysis  3.) No Association Between Preprocedural Fasting and Witnessed Pulmonary Aspiration: A Systematic Review and Meta-Analysis  4.) What Does a Doctor Look Like? Asking AI  CTSNet Content Mentioned  1.) Robotic Anterolateral Approach for Left Secondary Carinal Tumor Resection and Reconstruction   2.) Neonatal Off-Pump Blalock-Taussig-Thomas Shunt for Double Outlet Right Ventricle With RVOTO   3.) Minimally Invasive Bi-IMA OPCAB Via Left Thoracotomy   Other Items Mentioned  1.) Instructional Video Competition   2.) Career Center   3.) CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

We discuss how living meta‑analyses—meta‑analyses that are continuously updated as new studies appear—can cut research waste and keep evidence current. We also chat about how using synthetic research participants is a terrible idea. Links * The BMJ Christmas special paper on how recent is "recent" (https://www.bmj.com/content/391/bmj-2025-086941) * The synthetic panel (https://www.qualtrics.com/support/survey-platform/distributions-module/synthetic-panels/) service * The paper (https://doi.org/10.1016/j.psyneuen.2025.107713) describing a living meta-analysis platform for oxytocin research * A preprint commentary (https://doi.org/10.31234/osf.io/udexg_v1) on living meta-analysis Social media links - Dan on Bluesky (https://bsky.app/profile/dsquintana.bsky.social) - James on Bluesky (https://bsky.app/profile/jamesheathers.bsky.social) - Everything Hertz on Bluesky (https://bsky.app/profile/hertzpodcast.bsky.social)

Dr. Jim Dunlap discusses one of the honorable mention articles of 2024, titled “Does Headgear Prevent Sport-Related Concussion? A Systematic Review and Meta-Analysis of Randomized Controlled Trials Including 6,311 Players and 173,383 Exposure Hours,” which was originally published in Sports Health. Dr. Jeremy Schroeder serves as the series host. Dr. Dunlap is a member of the Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2024, as selected for the 2025 AMSSM Annual Meeting. Does Headgear Prevent Sport-Related Concussion? A Systematic Review and Meta-Analysis of Randomized Controlled Trials Including 6311 Players and 173,383 Exposure Hours: https://journals.sagepub.com/doi/10.1177/19417381231174461

Dorian Varović is a coach and a researcher, currently working on his PhD on muscle length and regional muscle hypertrophy.He and his colleagues also recently conducted a very interesting study comparing regular resistance training and isometrics for hypertrophy.In this conversation, we delve into all these topics:The latest research on the importance of training muscles at long muscle lengthsHow training at long muscle lengths may or may not affect regional hypertrophyAre isometrics as good as regular training for growth?… And more!Links and resources:“Does Muscle Length Influence Regional Hypertrophy? A Systematic Review and Meta-Analysis” - https://pubmed.ncbi.nlm.nih.gov/40570881/ “The effects of long muscle length isometric versus full range of motion isotonic training on regional quadriceps femoris hypertrophy in resistance-trained individuals” - https://pubmed.ncbi.nlm.nih.gov/40911904/ Connect with Dorian on Instagram @varovicdorian: https://www.instagram.com/varovicdorian/Follow his research on ResearchGate: https://www.researchgate.net/profile/Dorian-Varovic-2 Apply for coaching with him: https://docs.google.com/forms/d/e/1FAIpQLSeGiZCo7fG8d78dCHgOHvgeu1dCh7AKL-sfRpw478MmGZtWxw/viewform?usp=send_form Sign up for one on one coaching with me: ⁠https://www.fittotransformtraining.com/coaching.html⁠Follow me on Instagram @nikias_fittotransform: ⁠http://instagram.com/nikias_fittotransform/⁠Visit my website: ⁠https://www.fittotransformtraining.com⁠Sign up for my free newsletter: ⁠https://mailchi.mp/157389602fb0/mailinglist⁠Subscribe to my YouTube channel: https://www.youtube.com/@nikias_fittotransform Sign up for the No Quit Kit email series on retraining your mindset for long-term fat loss success: ⁠https://mailchi.mp/4b368c26baa8/noquitkitsignup⁠Take my free “Should You Cut or Bulk First?” quiz: https://nikias-dddr9p81.scoreapp.com/ 

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. Gavin Wright, thoracic surgeon and Director of Surgical Oncology at St Vincent's Hospital Melbourne, Australia, and thoracic surgeon and CTSNet Senior Editor Leanne Ashrafian about Dr. Wright's thoughts on the JCOG0802 trial and why he prefers segmentectomy over lobectomy. Chapters 00:00 Intro 02:59 JANS 1, Chest Tube Removal Review 05:33 JANS 2, Tricuspid Ann Remodeling 07:53 JANS 3, The Cost of Gender in MV Surgery 09:42 JANS 4, Endo Balloon vs Clamping 11:53 AVR & LIMA to LAD via Bi Minithorac 13:13 Surgical Reimplant ARCAPA 14:14 Editors Picks 2025 20:41 Gavin Wright, Segmentectomy vs Lob 44:33 Upcoming Events 45:56 Instructional Video Competition 46:12 Career Center 46:35 Closing They discussed the findings of the JCOG0802 trial and compared it to the CALGB 140503 trial. They also covered the use of FEV1 as an assessment tool, the significance of p-values, local recurrence, and Type I errors. Additionally, they reviewed The Lancet paper addressing segmentectomy vs lobectomy. Furthermore, they explored potential future trials, including the debate over wedge resection vs segmentectomy.   Joel also highlights recent JANS articles on a systematic review and meta-analysis on chest tube removal after cardiac surgery in first vs. second postoperative day, tricuspid annular remodeling in tachycardia induced cardiomyopathy with functional tricuspid regurgitation, a propensity-score matched analysis on the silent cost of gender in mitral valve surgery, and endo-aortic balloon occlusion versus transthoracic clamping in minimally invasive mitral valve surgery.  In addition, Joel explores endoscopic AVR and LIMA to LAD via bilateral minithoracotomy, surgical reimplantation of the anomalous origin of the right coronary artery from the pulmonary artery (ARCAPA), and the 2025 CTSNet Editors' Picks. Before closing, Joel highlights upcoming events in CT surgery.    JANS Items Mentioned  1.) Chest Tube Removal After Cardiac Surgery in First vs. Second Post-Operative Day: A Systematic Review and Meta-Analysis  2.) Tricuspid Annular Remodeling in Tachycardia Induced Cardiomyopathy With Functional Tricuspid Regurgitation  3.) The Silent Cost of Gender in Mitral Valve Surgery: A Propensity-Score Matched Analysis   4.) Endo-Aortic Balloon Occlusion Versus Transthoracic Clamping in Minimally Invasive Mitral Valve Surgery  CTSNet Content Mentioned  1.) Endoscopic AVR and LIMA to LAD Via Bilateral Minithoracotomy   2.) Surgical Reimplantation of the Anomalous Origin of the Right Coronary Artery From the Pulmonary Artery (ARCAPA)   3.) CTSNet Summarized—Editors' Picks 2025  Other Items Mentioned  1.) Instructional Video Competition   2.) 2025 CTSNet Recruitment Guide    3.) Career Center   4.) CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

„Geh doch mal zur Osteopathin, das hilft bestimmt!“ – ein Satz, den fast alle Eltern irgendwann hören. Aber was steckt eigentlich hinter der Kinderosteopathie? In dieser Folge sprechen wir mit dem Kinder- und Jugendarzt Pierre Teichmann darüber, warum sie so beliebt ist, welche Versprechen sie gibt und was die Wissenschaft wirklich dazu sagt. +++Shownotes:Pierres Artikel "Wie der Ast gebogen wird, so wächst der Baum": https://kinderaerzte-im-aerztehaus.de/wp-content/uploads/2025/06/Thema-Kinderosteopathie.pdf, Pierre erwähnte folgende Studien: KiSS/ Asymmetrie: Sacher, R. et al (2024). Multicentric RCT on one-time manual medicine treatment of infantile postural and motor asymmetries (KISS)—Spreewald trial II. Manuelle Medizin, 62(2), 102–109. https://doi.org/10.1007/s00337-024-01046-0, Philippi, H. et al (2006). Infantile postural asymmetry and osteopathic treatment: A randomized therapeutic trial. Developmental Medicine and Child Neurology, 48(1), 5–9. https://doi.org/10.1017/S001216220600003X, Metaanalyse muskuloskeletale Beschwerden/ Rückenschmerzen: Ceballos-Laita, L. et al (2024). Is Osteopathic Manipulative Treatment Clinically Superior to Sham or Placebo for Patients with Neck or Low-Back Pain? A Systematic Review with Meta-Analysis. In Diseases (Bd. 12, Nummer 11). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/diseases12110287, Metaanalysen kraniosakrale Therapie: Ceballos-Laita, L. et al (2024). Is Craniosacral Therapy Effective? A Systematic Review and Meta-Analysis. In Healthcare (Switzerland) (Bd. 12, Nummer 6). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/healthcare12060679, Amendolara, A. et al (2024). Effectiveness of osteopathic craniosacral techniques: a meta-analysis. Frontiers in Medicine, 11. https://doi.org/10.3389/fmed.2024.1452465, Reviews Kinderosteopathie: Posadzki, P. et al (2013). Osteopathic manipulative treatment for pediatric conditions: A systematic review. In Pediatrics (Bd. 132, Nummer 1, S. 140–152). American Academy of Pediatrics. https://doi.org/10.1542/peds.2012-3959, Posadzki, P. et al (2022). Osteopathic Manipulative Treatment for Pediatric Conditions: An Update of Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 11(15). https://doi.org/10.3390/jcm11154455, Franke, H. et al (2022). Effectiveness of osteopathic manipulative treatment for pediatric conditions: A systematic review. Journal of Bodywork and Movement Therapies, 31, 113–133. https://doi.org/10.1016/j.jbmt.2022.03.013, exzessives Schreien und Osteopathie: Schwerla, F. et al (2021). Osteopathic Treatment of Infants in Their First Year of Life: A Prospective Multicenter Observational Study (OSTINF Study). Complementary Medicine Research, 28(5), 395–406. https://doi.org/10.1159/000514413, Cabanillas-Barea, S. et al (2023). Systematic review and meta-analysis showed that complementary and alternative medicines were not effective for infantile colic. In Acta Paediatrica, International Journal of Paediatrics (Bd. 112, Nummer 7, S. 1378–1388). John Wiley and Sons Inc. https://doi.org/10.1111/apa.16807, Carnes, D. et al (2024). Usual light touch osteopathic treatment versus simple light touch without intent in the reduction of infantile colic crying time: A randomised controlled trial. International Journal of Osteopathic Medicine, 51. https://doi.org/10.1016/j.ijosm.2024.100710, Stellungnahmen Gesellschaft für Neuropädiatrie: Gesellschaft für Neuropädiatrie e.V. (GNP). (2005). Stellungnahme: Manualmedizinische Behandlung des KISS-Syndroms und Atlastherapie nach Arlen. In Manuelle Medizin (Bd. 43, Nummer 2). Springer Science and Business Media LLC. https://doi.org/10.1007/s00337-005-0351-y, Gesellschaft für Neuropädiatrie (GNP), Deutsche Gesellschaft für Sozialpädiatrie und Jugendmedizin (DGSPJ), Berufsverband der Kinder- und Jugendärzte (BVKJ), & Deutsche Akademie für Kinder- und Jugendmedizin (DAKJ). (2015). Stellungnahme Osteopathie bei Kindern. https://www.dgspj.de/wp-content/uploads/service-stellungnahme-osteopathie-2015.pdf, Weitere Literatur: Teichmann, P. (2025). Kinderosteopathie - Falsche Versprechen. Deutsche Hebammen Zeitschrift (DHZ), 77(4), 66–71. https://staudeverlag.de/falsche-versprechen/, Maier , J. (2016). In guten Händen? DIE ZEIT. https://www.zeit.de/2016/33/osteopathie-babies-orthopaedie-gesundheit-medizin-saeuglinge/+++ Alle Rabattcodes und Infos zu unseren Werbepartnern findet ihr hier: https://linktr.ee/Wunschkind_Podcast ++++++ Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://datenschutz.ad-alliance.de/podcast.html +++ Wir verarbeiten im Zusammenhang mit dem Angebot unserer Podcasts Daten. Wenn Sie der automatischen Übermittlung der Daten widersprechen wollen, klicken Sie hier: https://datenschutz.ad-alliance.de/podcast.htmlUnsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

Dr. Lee Mancini discusses one of the honorable mention articles of 2024, titled “Effects of Acute Sleep Deprivation on Sporting Performance in Athletes: A Comprehensive Systematic Review and Meta-Analysis,” which was originally published in Nature of Science and Sleep in March 2024. Dr. Jeremy Schroeder serves as the series host. Dr. Mancini is the Co-Chair of the Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2024, as selected for the 2025 AMSSM Annual Meeting. Effects of Acute Sleep Deprivation on Sporting Performance in Athletes: A Comprehensive Systematic Review and Meta-Analysis: https://pubmed.ncbi.nlm.nih.gov/39006249

Broadcast from KSQD, Santa Cruz on 12-18-2025: Dr. Dawn opens by examining how market competition is actually working in the weight loss drug sector. Novo Nordisk's Ozempic and Wegovy compete against Eli Lilly's Monjaro and ZepBound, with prices dropping nearly 50% as companies launch direct-to-consumer websites. The main barriers remain needles and refrigeration, driving development of oral versions. Novo's Wegovy pill awaits FDA approval for early 2026 launch at $150 monthly. Next-generation drugs show remarkable results: Eli's retatrutide causes 24% weight loss in 48 weeks, while Novo's Cagrisema combines semaglutide with amylin to reduce muscle loss. Pfizer paid $10 billion for Metsera's once-monthly drug despite significant side effects. A quick fiber tip suggests adding plain psyllium to morning coffee for cardiovascular and microbiome benefits. Start with half a teaspoon and work up to two teaspoons (10 grams) over several weeks to avoid gas. The prebiotic fiber improves glucose tolerance and may reduce cancer risk. UC San Diego scientists discovered why cancers mutate so rapidly despite being eukaryotic cells with protected chromosomes. The answer is chromothripsis, a catastrophic event where the enzyme N4BP2 literally explodes chromosomes into fragments. These reassemble incorrectly, generating dozens to hundreds of mutations simultaneously and creating circular DNA fragments carrying cancer-promoting genes. One in four cancers show evidence of this mechanism, with all osteosarcomas and many brain cancers displaying it. This explains why the most aggressive cancers resist treatment. Research from 2013 shows any glucocorticoid use significantly increases venous thromboembolism risk, with threefold increases during the first month of use. The risk applies to new and recurrent clots, affecting both oral and inhaled steroids, though IV poses highest risk and topical the lowest. Joint injections fall somewhere between inhaled and oral. Anyone with prior blood clots should avoid steroids except for life-threatening situations like severe asthma attacks requiring ventilation. A meta-analysis of 20 randomized controlled trials shows creatine supplementation helps older adults (48-84) maintain muscle mass when combined with weight training two to three times weekly. The supplement provides no benefit without exercise. Recommended dosing starts at 2 grams and works up to 5 grams daily. Vegans benefit most since they consume little meat or fish. Important caveat: creatine throws off standard kidney function tests (creatinine), so users should request cystatin C testing instead for accurate renal health assessment. A new JAMA study suggesting risk-based mammogram screening is fatally flawed. First, researchers offered chemopreventative drugs like tamoxifen only to the high-risk group, contaminating the study design. Second, the demographics skewed heavily toward white college-educated women, missing the reality that Black women face twice the risk of aggressive breast cancer with 40% higher mortality. Third, wild-type humans failed to follow instructions—low-risk women continued getting annual mammograms anyway while high-risk women skipped recommended extra screenings. The conclusion of "non-inferior" outcomes is meaningless given poor adherence. Stick with annual mammograms, and consider alternating with MRIs for high-risk women. The EAT-Lancet report condemns red meat based purely on observational data showing correlations with heart disease, cancer, and mortality. But people who eat lots of red meat differ dramatically from low consumers: they weigh more, smoke more, exercise less, and eat less fiber. Studies can't control for sleep quality, depression, or screen time. Notably, heavy meat eaters also die more in accidents, suggesting a risk-taking lifestyle phenotype. The inflammatory marker TMAO is higher in meat eaters, but starch is also pro-inflammatory. Eating red meat instead of instant ramen might improve health. A balanced diet with limited amounts beats epidemiology-based blanket statements. Dr. Dawn grades Dr. Oz's performance as CMS administrator. Starting at minus one for zero relevant experience, he earns plus two for promoting diet, exercise, and gut health on his show. He studied intensively after nomination, calling all four previous CMS directors repeatedly and surrounding himself with experienced staff (plus one). He finalized Medicare rules favoring prevention over surgery and earned bipartisan praise as "a real scientist, not radical" (plus one). He divested healthcare holdings but kept some blind trust interests (minus 0.5). He's developing a CMS app and partnering with Google on a digital health ecosystem (plus one), but supports ending ACA subsidies that will raise premiums for millions (minus one). He correctly promoted COVID vaccines and contradicted Trump's Tylenol-autism claims (plus one). Final score: 3.5 out of 5 possible points, the only positive score for any Trump health administrator.

Welcome to part two of our Best of 2025 series - the moments that changed how our listeners think about their health and what they do on a day-to-day basis. In this episode, we delve into simple questions with profound impact. Is it safe to experiment with your own health? Does cheese really cause bad dreams? Why do some breakfasts leave you tired and hungry, while others don't?  If you're looking for practical, science-led ideas you can take into the year ahead, this episode brings together the insights listeners found most useful, surprising, and worth returning to. Unwrap the truth about your food

Drs Joseph Mikhael and Shaji Kumar discuss the future of multiple myeloma, including enhanced diagnostics for detecting myeloma, frontline therapy, and durable responses. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002718. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Multiple Myeloma https://emedicine.medscape.com/article/204369-overview Updated Diagnostic Criteria and Staging System for Multiple Myeloma https://pubmed.ncbi.nlm.nih.gov/27249749/ Mass Spectrometry for the Evaluation of Monoclonal Proteins in Multiple Myeloma and Related Disorders: An International Myeloma Working Group Mass Spectrometry Committee Report https://pubmed.ncbi.nlm.nih.gov/33563895/ Multiple Myeloma Imaging https://emedicine.medscape.com/article/391742-overview Next-Generation Biomarkers in Multiple Myeloma: Understanding the Molecular Basis for Potential Use in Diagnosis and Prognosis https://pubmed.ncbi.nlm.nih.gov/34299097/ Monoclonal Gammopathy of Undetermined Significance https://www.ncbi.nlm.nih.gov/books/NBK507880/ Primary Plasma Cell Leukemia: Consensus Definition by the International Myeloma Working Group According to Peripheral Blood Plasma Cell Percentage https://pubmed.ncbi.nlm.nih.gov/34857730/ Advancing MRD Detection in Multiple Myeloma: Technologies, Applications, and Future Perspectives https://pubmed.ncbi.nlm.nih.gov/40214184/ Genomic Landscape of Multiple Myeloma and Its Precursor Conditions https://pubmed.ncbi.nlm.nih.gov/40399554/  Quadruplet Regimens for Patients With Newly Diagnosed Multiple Myeloma: A Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/39348665/ Subcutaneous Daratumumab (Dara) + Bortezomib/Lenalidomide/Dexamethasone (VRd) With Dara + Lenalidomide (DR) Maintenance in Transplant-Eligible (TE) Patients With Newly Diagnosed Multiple Myeloma (NDMM): Analysis of Sustained Minimal Residual Disease Negativity in the Phase 3 PERSEUS Trial https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.7501 Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone Induction in Newly Diagnosed Myeloma: Analysis of the MIDAS Trial https://pubmed.ncbi.nlm.nih.gov/39841461/ Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant Is Not a Medically Suitable Treatment https://www.clinicaltrials.gov/study/NCT05561387 Cytokine Release Syndrome and Associated Neurotoxicity in Cancer Immunotherapy https://pubmed.ncbi.nlm.nih.gov/34002066/ The Role of CELMoD Agents in Multiple Myeloma https://pmc.ncbi.nlm.nih.gov/articles/PMC12399888/ Phase 2 Study of Talquetamab + Teclistamab in Patients With Relapsed/Refractory Multiple Myeloma and Extramedullary Disease: REDIRECTT-1 https://library.ehaweb.org/eha/2025/eha2025-congress/4173809/shaji.kumar.phase.2.study.of.talquetamab.2B.teclistamab.in.patients.with.html Discovery of a Novel Class NSD2 Inhibitor for Multiple Myeloma With t(4;14) https://pubmed.ncbi.nlm.nih.gov/40949769/ Long-Term (≥5 Year) Remission and Survival After Treatment With Ciltacabtagene Autoleucel (Cilta-Cel) in CARTITUDE-1 Patients (Pts) With Relapsed/Refractory Multiple Myeloma (RRMM) https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.7507

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning speaks with Dr. Nasser Altorki, thoracic surgeon at Weill Cornell Medicine in New York, and thoracic surgeon and CTSNet Senior Editor Leanne Ashrafian about the 10-year results from the JCOG0802 trial. Chapters 00:00 Intro 02:56 JANS 1, Re-Repair vs Replacement 05:07 JANS 2, Mini Mitral Multicentre RCT 07:01 JANS 3, PERSEVERE Study 08:54 JANS 4, Parietal Pleurectomy vs Pleural Abrasion 11:38 Career Center 12:33 Video 1, Endoscopic Post-Infarction VSD Repair 14:11 Video 2, 3D Dor Procedure & MVR Huge LV Aneurysm 15:19 Video 3, Non-Cardioplegic Myo Protection Robotic 17:16 Nasser Altorki Interview, JCOG 45:16 Upcoming Events 47:20 Closing They discuss key aspects of the trial, including the noninferiority primary endpoint. Dr. Altorki shares his overall thoughts on the trial, and they also examine topics such as pulmonary function, lobar vs sublobar resection, and segmentectomy vs wedge resection. Additionally, they explore secondary primary lung cancer, the importance of thoracic surgeons presenting data to patients, and best practices for segmentectomy to ensure patient safety. They also examine good wedge resection vs bad wedge resection, planning for segmentectomy, and the future of lobectomy and segmentectomy.   Joel also highlights recent JANS articles on the outcomes of re-repair vs replacement after failed primary mitral regurgitation repair, minimally invasive thoracoscopically-guided right minithoracotomy vs conventional sternotomy for mitral valve repair, one-year results of novel aortic arch hybrid prosthesis for repair of acute DeBakey Type I dissection with malperfusion, and a meta-analysis of efficacy and safety of parietal pleurectomy vs pleural abrasion in treating spontaneous pneumothorax.  In addition, Joel explores endoscopic post-infarction VSD repair, 3D video-assisted endoscopic Dor procedure and MVR for post-infarction huge LV aneurysm, and non-cardioplegic myocardial protection for robotic mitral surgery. Before closing, Joel highlights upcoming events in CT surgery.    JANS Items Mentioned  1.) Outcomes of Re-Repair Versus Replacement After Failed Primary Mitral Regurgitation Repair: STS Adult Cardiac Surgery Database Analysis  2.) Minimally Invasive Thoracoscopically-Guided Right Minithoracotomy Versus Conventional Sternotomy for Mitral Valve Repair: The UK Mini Mitral Multicentre RCT  3.) One-Year Results of Novel Aortic Arch Hybrid Prosthesis for Repair of Acute DeBakey Type I Dissection With Malperfusion: PERSEVERE Study  4.) A Meta-Analysis of Efficacy and Safety of Parietal Pleurectomy Versus Pleural Abrasion in Treating Spontaneous Pneumothorax  CTSNet Content Mentioned  1.) Endoscopic Post-Infarction VSD Repair  2.) Pushing Surgical Boundaries: 3D Video-Assisted Endoscopic Dor Procedure and MVR for Post-Infarction Huge LV Aneurysm  3.) Non-Cardioplegic Myocardial Protection for Robotic Mitral Surgery  Other Items Mentioned  1.) Instructional Video Competition  2.) 2025 Endoscopic Cardiac Surgeons Club Video Competition  3.) 2025 CTSNet Recruitment Guide   4.) Career Center   5.) CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

In this episode of the Award-winning PRS Journal Club Podcast, 2025 Resident Ambassadors to the PRS Editorial Board – Christopher Kalmar, Ilana Margulies, and Amanda Sergesketter- and special guest, Bradley Calobrace, MD, discuss the following articles from the December 2025 issue: "Complications following Primary Implant-Based Gluteal Augmentation: A Systematic Review and Meta-Analysis" by Elsaftawy, Bonczar, Jagosz, et al. Read the article for FREE: https://bit.ly/ImplantGlutealAug Special guest, Dr. Calobrace is a nationally recognized plastic surgeon, an accomplished researcher, and a trusted educator whose work has shaped best practices in breast surgery and aesthetic medicine. Dr. Calobrace is a graduate of Indiana University Medical School and completed residencies in both general surgery and plastic surgery at the University of Southern California in Los Angeles. Subsequently, he completed a cosmetic and breast surgery fellowship with Dr. Pat Maxwell and began practice in Louisville, Kentucky. Although most known for aesthetic breast surgery nationally and internationally, Dr. Calobrace has a thriving aesthetic practice and fellowship in aesthetic surgery comprising an equal mix of breast, body, and facial aesthetic surgery. READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCDec25Collection The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

From the viral moment on The Traitors to the biology of the "silent but deadly," this episode is an unashamed deep dive into flatulence. Drs Siobhan and Sheena are joined by Julie Thompson, Lead Dietitian at Guts UK Charity, to break the stigma around passing wind. We discuss what normal gas looks like, why fiber makes us farty (and why that's a good thing!), and the truth about the Low FODMAP diet for IBS sufferers. Plus, we answer the important questions: Do spiders fart? And do charcoal underpants actually work?Featured Guest:Julie Thompson is a Gastroenterology Specialist Dietitian with over 16 years of experience supporting people with digestive diseases. She has a particular interest in disorders of gut-brain interaction, such as Irritable Bowel Syndrome (IBS).A leading voice in her field, Julie contributed to the British Dietetic Association's (BDA) dietary guidelines for IBS and has delivered the BDA's Low FODMAP diet training to dietitians across the UK. She currently serves as the Information Manager at the charity Guts UK and sits on the BSG Gut Microbiota for Health Expert Panel.References and resources:Guts UK Charity: https://gutscharity.org.uk/Book: Fartology by Stefan GatesBook: Does It Fart? by Nick Caruso & Dani RabaiottiThe Physics of Farts: Ancalle, D., et al. (2021). "Physics of flatulence." The Journal of the Acoustical Society of America.What is a "Normal" Amount of Gas? Modesto, A., et al. (2021). "Meta-Analysis of the Composition of Human Intestinal Gases." Digestive Diseases and Sciences.Microbes & Metabolism: Rowland, I., et al. (2018). "Gut microbiota functions: metabolism of nutrients and other food components." European Journal of Nutrition. (See the excellent section on intestinal gas & microbes!)Carb Intolerance: Fernández-Bañares, F. (2022). "Carbohydrate Maldigestion and Intolerance." Nutrients.The "Bean Study": Winham, D., & Hutchins, A. (2011). "Perceptions of flatulence from bean consumption among adults in 3 feeding studies." Nutrition Journal. (Evidence that the gas often goes away after a few weeks!)Symptoms in the UK: Thomson, C., Garcia, A., & Edwards, C. (2021). "Digestive symptoms, diet and demographics in UK adults." Proceedings of the Nutrition Society.Global Gas Survey: Palsson, O.S., et al. (2025). "Gas-Related Symptoms in the General Population: Prevalence, Impact and Associated Factors." Neurogastroenterology & Motility.This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.Disclaimer:The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

Two questions I get a lot from people who are new to Biohacking and cognitive enhancers are...❓ Which Smart Drugs actually work and have science behind them?❔ Which Nootropic should I get started with?⚡ My answer to both questions is the same: PiracetamIt has a significant body of scientific evidence behind it; over 750 human studies and academic papers have been published about Piracetam on PubMed, with over ten meta-analysis papers in just the past decade.9:51 Scientific Research11:52 Memory Enhancement17:50 Mitochondrial Nootropic19:47 Stroke Recovery20:12 Cognitive Enhancer20:50 Verbal Fluency22:45 Cognitive Decline24:26 Vs Alzheimer's24:53 Mechanism of Action26:42 History27:13 Vs Depression29:50 Sources35:43 Piracetam Non-Responders?37:10 Tolerance37:28 Post-Piracetam Intelligence Deficit43:09 Addiction or Dependence?43:50 Experiential46:47 Featured in Fiction47:21 Dosage & Cofactors49:22 Side Effects & Risks56:23 ConclusionRead Meta-Analysis

Full article: Artificial Intelligence for CT and MRI Protocoling: A Meta-analysis of Traditional Machine Learning, Transformer, and Large Language Models CT and MRI protocoling can pose substantial time burdens for radiologists. Selima Siala, MD, discusses this AJR article by Sacoranksy et al. that reports a meta-analysis comparing traditional machine-learning, transformer, and large language models for automated examination protocoling.

In this episode, Lenny Murphy sits down with Hakan Yurdakul, CEO of Bolt Insight, to unpack how AI-native research is reshaping qual and quant. Hakan shares his Unilever-to-founder origin story and the personal “bring summer forward” purpose that drives Bolt's human-centric philosophy. They dig into BoltChatAI and why AI-moderated qual only works when it's trained on real human interviews and supported by rigorous human-in-the-loop checkpoints.The conversation explores Bolt's Dynamic Personas—living profiles that refresh with ongoing human input—plus the limits of synthetic data for innovation. Finally, Hakan lays out a “Jarvis-style” vision for an AI assistant insights officer, and the duo reflects on what this shift means for trust, ethics, and the evolving role of researchers as strategists and storytellers.Key Discussion Points:Hakan's path from Unilever marketing/insights to founding Bolt Insight—and the “bring summer forward” mission guiding the company.What it means to be an AI-native research firm across quant + qual, and why “qual at scale” is now feasible.Human-in-the-loop AI moderation: training on real interviews, quality scoring, and guardrails to avoid “chatbot research.”Dynamic (living) personas and meta-analysis: how Bolt keeps personas current and useful without over-relying on historic synthetic data.The next 2–5 years: AI automates grunt work, pushing researchers toward strategy, storytelling, and doing more with the same.Resources & Links:Bolt InsightBoltChatAI features: Dynamic Personas and Meta-Analysis.2025 GRIT Business & Innovation ReportYou can reach out to Hakan Yurdakul on LinkedIn.Many thanks to Hakan Yurdakul for being our guest. Thanks also to our production team and our editor at Big Bad Audio.

Having data is sometimes different than having clinically applicable data. This is exactly the issue with the proposed plan to reduce surgical site infection (SSI) by changing surgical gloves after placental delivery at C-Section. Just 24 hours ago, we received the question from a PGY4 OBGYN resident asking whether the practice of changing surgical gloves at C-Section after placental delivery to reduce SSI was evidence-based. So, in this episode, we will review the data - which is timely since this was recently published on November 13, 2025 in the J Hospital Infection. This study follows a statement on this practice released by FIGO in September 2025. It's an interesting proposal, and there is clearly data in support of this, yet the ACOG and CDC do not recommend this practice as of Nov 2025. Is there a disconnect? Listen in for details. 1. FIGO: https://www.figo.org/news/new-ijgo-review-provides-comprehensive-framework-preventing-post-caesarean-sepsis (International Journal of Gynecology & Obstetrics)2. Stanberry B, Jordan L, Pullyblank A, Hargreaves J. Glove change during caesarean birth: impact on maternity service budgets and capacity. J Hosp Infect. 2025 Nov 13:S0195-6701(25)00354-8. doi: 10.1016/j.jhin.2025.10.033. Epub ahead of print. PMID: 41241232.3. Narice BF, Almeida JR, Farrell T, Madhuvrata P. Impact of Changing Gloves During Cesarean Section on Postoperative Infective Complications: A Systematic Review and Meta-Analysis. Acta Obstetricia Et Gynecologica Scandinavica. 2021;100(9):1581-1594. doi:10.1111/aogs.14161.4. Routine Sterile Glove and Instrument Change at the Time of Abdominal Wound Closure to Prevent Surgical Site Infection (ChEETAh): A Pragmatic, Cluster-Randomised Trial in Seven Low-Income and Middle-Income Countries.NIHR Global Research Health Unit on Global Surgery. Lancet (London, England). 2022;400(10365):1767-1776. doi:10.1016/S0140-6736(22)01884-0.5. Gialdini C, Chamillard M, Diaz V, Pasquale J, Thangaratinam S, Abalos E, Torloni MR, Betran AP. Evidence-based surgical procedures to optimize caesarean outcomes: an overview of systematic reviews. EClinicalMedicine. 2024 May 19;72:102632. doi: 10.1016/j.eclinm.2024.102632. PMID: 38812964; PMCID: PMC11134562.

A Systematic Review and Meta-Analysis of Psychosocial Interventions for Persons with Comorbid Anxiety and Substance Use DisordersIn this episode, Dr. Jud dives into the comprehensive findings of a meta-analysis on psychosocial interventions for individuals facing the dual challenge of anxiety and substance use disorders. This research sheds light on the efficacy of treatments like cognitive behavioral therapy (CBT), motivational interviewing, and integrated care in addressing anxiety, alcohol consumption, and substance use. Join us as we explore the transformative potential of these interventions, the complexities of treating co-occurring conditions, and the pressing gaps in research for broader substance categories like opioids and methamphetamines.Reference: Nardi, W. R., Kelly, P., Roy, A., Becker, S., Brewer, J., & Sun, S. (2024). A systematic review and meta-analysis of psychosocial interventions for persons with comorbid anxiety and substance use disorders. Journal of Substance Use and Addiction Treatment, 165, 209442. DOI: 10.1016/j.josat.2024.209442Let's connect on Instagram

On Episode 58 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2025 issue of Stroke: "Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network" and "Apixaban and Recurrent Stroke Risk With Left Ventricular Dysfunction: A Secondary Analysis of the ARCADIA Trial." She also interviews Drs. Aaron Rodriguez-Calienes and Santiago Ortega-Gutierrez about their article "Endovascular Thrombectomy Versus Best Medical Therapy for Large Vessel Occlusion Stroke Beyond 24 Hours: A Systematic Review and Meta-Analysis." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251114.13070

The US has no shortage of lidocaine patch television commercials. Topical lidocaine has a role for local, topical, minor aches and pains. What about lidocaine patches for post-op cesarean section pain? Is there data for that? A brand-new meta-analysis in AJOG-MFM (Nov 13, 2025) looks at this option. However, there has been 3 prior reviews on the same topic from 2019, 2022, and 2023. Do they all arrive at the same result? Listen in for details!1.     Smoker J, Cohen A, Rasouli MR, Schwenk ES. TransdermalLidocaine for Perioperative Pain: A Systematic Review of the Literature. Current Pain and Headache Reports.2019;23(12):89. doi:10.1007/s11916-019-0830-9.2.     Koo CH, Kim J, Na HS, Ryu JH, Shin HJ. TheEffect of Lidocaine Patch for Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Anesthesia. 2022;81:110918.doi:10.1016/j.jclinane.2022.110918.3.     Wu X, Wei X, Jiang L, et al. Is Lidocaine PatchBeneficial for Postoperative Pain?: A Meta-Analysis of Randomized Clinical Trials. The Clinical Journal of Pain. 2023;39(9):484-490. doi:10.1097/AJP.00000000000011354.     Parisi, Nadia et al.Lidocaine patches aftercesarean delivery: a meta-analysis of randomized controlled trials. American Journal of Obstetrics & Gynecology MFM, Volume 0, Issue 0, 101832

Join Kristin Coverly as she explores the health benefits of gratitude, practices to incorporate into your daily life, and chats with guests Allison Denney and Ann and Lynn Teachworth about their gratitude practices. Gain information and tools you can immediately apply to your personal and professional lives! Resources: ABMP Education Center: https://www.abmp.com/learn/ ABMP CE Socials Event: https://www.abmp.com/ce-socials What is Gratitude and Why Is It So Important?: https://positivepsychology.com/gratitude-appreciation/ The Neuroscience of Gratitude & Its Effects on the Brain: https://positivepsychology.com/neuroscience-of-gratitude/ The Effects of Gratitude Interventions: A Systematic Review and Meta-Analysis: https://pmc.ncbi.nlm.nih.gov/articles/PMC10393216/ Health benefits of gratitude: https://www.uclahealth.org/news/article/health-benefits-gratitude 11 Best Gratitude Apps to Increase Your Wellbeing: https://positivepsychology.com/gratitude-apps/ Host: Kristin Coverly, LMT is a massage therapist, educator, and the director of professional education at ABMP. She loves creating continuing education courses, events, and resources to support massage therapists and bodyworkers as they enhance their lives and practices. Contact her at ce@abmp.com. Guests: Allison Denney is a certified massage therapist and certified YouTuber. You can find her massage tutorials at YouTube.com/RebelMassage. She is also passionate about creating products that are kind, simple, and productive for therapists to use in their practices. Her products, along with access to her blog and CE opportunities, can be found at rebelmassage.com.  Ann and Lynn Teachworth of Trunamics integrate structural, functional, and energetic concepts to help good therapists be great. Ann is director of education at Inspirit School of Healing Arts. She integrates manual therapy, energetic modalities, the Franklin Method, yoga, breathwork, meditation, and mindfulness to help people understand and experience their design and function more fully. Lynn has been a licensed massage therapist for over 25 years, and he specializes in pain, sports injuries, and sports performance. One of only a few therapists in the world with advanced training in structural bodywork, biomechanics, movement, and energy medicine, he is able to address a wide variety of acute and chronic injuries. Learn more at www.trunamics.com. Sponsor: Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function.                      Website: anatomytrains.com                        Email: info@anatomytrains.com             Facebook: facebook.com/AnatomyTrains                       Instagram: www.instagram.com/anatomytrainsofficial   YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA   

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-458 Overview: In this episode, we explore the relationship between caffeine consumption and suicide risk. Hear how coffee may offer protective effects—while energy drinks raise concern—and gain practical tips for screening patients for caffeine and substance use as part of suicide risk assessment in primary care. Episode resource links: Low, C.E.; Chew, N.S.M.; Loke, S.; Tan, J.Y.; Phee, S.; Lee, A.R.Y.B.; Ho, C.S.H. Association of Coffee and Energy Drink Intake with Suicide Attempts and Suicide Ideation: A Systematic Review and Meta-Analysis. Nutrients 2025, 17, 1911. https://doi.org/10.3390/ nu17111911   Costantino, A., Maiese, A., Lazzari, J., Casula, C., Turillazzi, E., Frati, P., & Fineschi, V. (2023). The Dark Side of Energy Drinks: A Comprehensive Review of Their Impact on the Human Body. Nutrients, 15(18), 3922. https://doi.org/10.3390/nu15183922 Guest: Jill M. Terrien PhD, ANP-BC    Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-458 Overview: In this episode, we explore the relationship between caffeine consumption and suicide risk. Hear how coffee may offer protective effects—while energy drinks raise concern—and gain practical tips for screening patients for caffeine and substance use as part of suicide risk assessment in primary care. Episode resource links: Low, C.E.; Chew, N.S.M.; Loke, S.; Tan, J.Y.; Phee, S.; Lee, A.R.Y.B.; Ho, C.S.H. Association of Coffee and Energy Drink Intake with Suicide Attempts and Suicide Ideation: A Systematic Review and Meta-Analysis. Nutrients 2025, 17, 1911. https://doi.org/10.3390/ nu17111911   Costantino, A., Maiese, A., Lazzari, J., Casula, C., Turillazzi, E., Frati, P., & Fineschi, V. (2023). The Dark Side of Energy Drinks: A Comprehensive Review of Their Impact on the Human Body. Nutrients, 15(18), 3922. https://doi.org/10.3390/nu15183922 Guest: Jill M. Terrien PhD, ANP-BC    Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Send us a message with this link, we would love to hear from you. Standard message rates may apply.We break down osteopenia and osteoporosis with clear steps to protect independence: how bones weaken, how DEXA scoring works, and which daily habits reduce fracture risk. We share nutrition, exercise, lifestyle changes, and home safety that make a measurable difference.• key stats on fracture risk in women and men over 50• definitions of osteopenia and osteoporosis using T-scores• hip, spine and wrist as common fracture sites• why bone loss accelerates after menopause• risk factors including family history, smoking and low weight• DEXA scan basics and when to ask for screening• calcium and vitamin D targets and food sources• Mediterranean diet, protein and supportive micronutrients• weight-bearing, resistance and balance training essentials• Tai Chi and fall risk reduction• home safety changes that prevent falls• when medications like bisphosphonates or denosumab help• practical questions to ask your clinicianReferences1. Osteoporosis: Common Questions and Answers. Harris K, Zagar CA, Lawrence KV. American Family Physician. 2023;107(3):238-246.2. Postmenopausal Osteoporosis. Walker MD, Shane E. The New England Journal of Medicine. 2023;389(21):1979-1991. doi:10.1056/NEJMcp2307353.3. American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis-2020 Update. Camacho PM, Petak SM, Binkley N, et al. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2020;26(Suppl 1):1-46. doi:10.4158/GL-2020-0524SUPPL.4. Global, Regional Prevalence, and Risk Factors of Osteoporosis According to the World Health Organization Diagnostic Criteria: A Systematic Review and Meta-Analysis. Xiao PL, Cui AY, Hsu CJ, et al. Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2022;33(10):2137-2153. doi:10.1007/s00198-022-06454-3.5. Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement. Curry SJ, Krist AH, Owens DK, et al. JAMA. 2018;319(24):2521-2531. doi:10.1001/jama.2018.7498.6. The Cost of Osteoporosis, Osteopenia, and Associated Fractures in Australia in 2017. Tatangelo G, Watts J, Lim K, et al. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research. 2019;34(4):616-625. doi:10.1002/jbmr.3640.7. The Prevalence and Treatment Rate Trends of Osteoporosis in Postmenopausal Women. Zhang X, Wang Z, Zhang D, et al. PloS One. 2023;18(9):e0290289. doi:10.1371/journal.pone.0290289.8. Osteopenia: A Key Target for Fracture Prevention. Reid IR, McClung MR. The Lancet. Diabetes & Endocrinology. 2024;12(11):856-864. doi:10.1016/S2213-8587(24)00225-0.9. Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-Analysis for the American College of Physicians. Ayers C, Kansagara D, Lazur B, et al. Annals of Internal Medicine. 2023;176(2):182-195. doi:10.7326/M22-0684.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

A popular topic around women's health is PCOS, insulin resistance, and potential issues this can cause when attempting to lose fat in a dieting phase. Does PCOS directly affect fat and weight loss efforts or is there more to it? I want to share a recent meta-analysis on this topic and what we can learn as coaches or someone in their own transformation. Topics include: - Does PCOS Affect Fat Loss and Weight Loss for Women?- Cliffs Notes Version of This Study- PCOS Diagnosis and Insulin Resistance- My Book Metabolism Made Simple- Meta-Analysis of 78 Studies- Energy Expenditure As a Whole- Metabolically Active Brown Fat- Metabolic Adaptation- Applying This Information---------- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.metabolismschool.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- [Free] Metabolism School 101: The Video Series⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.metabolismschool.com/metabolism-101⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------Subscribe to My Youtube Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Grab a Copy of My New Book - Metabolism Made Simple⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- Stay Connected: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Youtube: SamMillerScience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: The Nutrition Coaching Collaborative Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠operations⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@sammillerscience.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

Send us a textAzithromycin for Prevention of Bronchopulmonary Dysplasia and Other Neonatal Adverse Outcomes in Preterm Infants: An Updated Systematic Review and Meta-Analysis.Joseph M, Murali Krishna M, Karlinksi Vizentin V, Provinciatto H, Ezenna C.Neonatology. 2025 Aug 12:1-10. doi: 10.1159/000547537. Online ahead of print.PMID: 40795809 Free article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Here is a real-world clinical case with a tricky differential: Our team recently readmitted a patient 6 days postpartum/post C-section (which was done for ICP and fetal macrosomia at close to 4500 grams, with A2GDM). She had elevated blood pressures, a frontal headache, some midepigastric pain/RUQ discomfort. Pretty clear picture right: sounds like preeclampsia (PreE) with severe features based on BP elevation and symptoms. So, we started her on mag-sulfate per protocol. Well, her transaminases were in the 400-600s, which was significantly higher than they were at delivery. They then peaked the next day at 900! OK, it still meets criteria for PreE with severe features. But could this also be postpartum Acute fatty Liver of Pregnancy (AFLP)? The clinical picture of these 2 conditions may overlap but there are distinct differences here. AFLP is potentially fatal, so we have to get that diagnosis correct. How can we distinguish AFLP from PreE with severe features or HELLP? Listen in for details.1. https://www.preeclampsia.org/the-news/health-information/acute-fatty-liver-of-pregnancy-can-be-confused-with-preeclampsia-and-hellp-syndrome2. Yemde A Jr, Kawathalkar A, Bhalerao A. Acute Fatty Liver of Pregnancy: A Diagnostic Challenge. Cureus. 2023 Mar 26;15(3):e36708. doi: 10.7759/cureus.36708. PMID: 37113350; PMCID: PMC10129069.3. Maalbi O, Elachhab N, Elkabbaj A, Arfaoui M, Hindi S, Lahbabi S, Oudghiri N, Tachinante R. Management of Acute Fatty Liver of Pregnancy: A Retrospective Study of 12 Cases Compared With Data in the Literature. Cureus. 2025 Jun 11;17(6):e85753. doi: 10.7759/cureus.85753. PMID: 40656400; PMCID: PMC12247011.4. Siwatch S, De A, Kaur B, et al. Safety and Efficacy of Plasmapheresis in Treatment of Acute Fatty Liver of Pregnancy-a Systematic Review and Meta-Analysis.Frontiers in Medicine. 2024;11:1433324. doi:10.3389/fmed.2024.1433324.5. Sarkar M, Brady CW, Fleckenstein J, et al.6. Reproductive Health and Liver Disease: Practice Guidance by the American Association for the Study of Liver Diseases.Hepatology (Baltimore, Md.). 2021;73(1):318-365. doi:10.1002/hep.31559.STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

Autism isn't new, but our understanding of it has changed dramatically. It's now recognized as a broad neurodevelopmental spectrum that shapes how millions of people perceive, process, and interact with the world. In this episode, we explore what autism is AND isn't, from its earliest signs in infancy to its deep genetic roots, and why misinformation about it continues to spread. We speak with three remarkable experts leading the field in early detection, genetics, and public education: DR. AMI KLIN, PhD, Director of the Marcus Autism Center at Emory University and a pioneer in early autism research, whose work shows autism can be identified in babies as young as two months old. DR. JOSEPH BUXBAUM, PhD, Director of the Seaver Autism Center at Mount Sinai and a global leader in autism genetics, uncovering hundreds of genes linked to the condition. DR. ANDREA LOVE, immunologist, microbiologist, and founder of ImmunoLogic, known for her clear, evidence-based communication about vaccines, immunity, and autism myths. Together, we discuss: • What autism really is, and how the definitions have evolved • How it develops in infancy (and why early diagnosis can be so critical) • The powerful genetic evidence behind autism • The persistence of vaccine myths, and how misinformation spreads • How technology like eye-tracking can detect autism early • The rise of “profound autism” and what it means for families • The future of genetics-based treatments and therapy Whether you're autistic yourself, a parent navigating a new diagnosis, or simply seeking understanding, we're thrilled to share this extensive, in-depth episode with you. This is... Your Brain On Autism. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ ‘Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Autism' • SEASON 6 • EPISODE 1 LINKS Dr. Ami Klin at Emory University: https://ctsn.emory.edu/faculty/klin-ami.html Dr. Ami Klin at Marcus Autism Center: https://www.marcus.org/about-marcus-autism-center/meet-our-leadership/ami-klin  Dr. Joseph Buxbaum at Mount Sinai: https://profiles.icahn.mssm.edu/joseph-d-buxbaum  Dr. Andrea Love's website: https://www.immunologic.org/ Dr. Andrea Love on Instagram: https://www.instagram.com/dr.andrealove  REFERENCES Autism Spectrum Disorder: A Review. JAMA, 2023. https://jamanetwork.com/journals/jama/article-abstract/2800182  Is There a Bias Towards Males in the Diagnosis of Autism? A Systematic Review and Meta-Analysis. https://link.springer.com/article/10.1007/s11065-023-09630-2  Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability. https://pubmed.ncbi.nlm.nih.gov/38592388/  Eye-Tracking–Based Measurement of Social Visual Engagement Compared With Expert Clinical Diagnosis of Autism. https://jamanetwork.com/journals/jama/fullarticle/2808996  Rare coding variation provides insight into the genetic architecture and phenotypic context of autism. https://www.nature.com/articles/s41588-022-01104-0  Rare coding variation illuminates the allelic architecture, risk genes, cellular expression patterns, and phenotypic context of autism. https://www.medrxiv.org/content/10.1101/2021.12.20.21267194v1  Andrew Wakefield and the fabricated history of the alleged vaccine-autism link. https://geneticliteracyproject.org/2024/04/29/andrew-wakefield-and-the-fabricated-history-of-the-alleged-vaccine-autism-link/ VACCINES & AUTISM 1. Major Cohort Studies Hviid et al., 2019 – Annals of Internal Medicine A nationwide study of 657,461 Danish children found no increased risk of autism in vaccinated children compared to unvaccinated peers — even among those with risk factors such as a sibling with autism. Ann Intern Med. 2019;170(8):513–520 Madsen et al., 2002 – New England Journal of Medicine In 537,303 Danish children, researchers found no difference in autism rates between vaccinated and unvaccinated groups, and no relationship with age, timing, or date of vaccination. NEJM. 2002;347:1477–1482 Jain et al., 2015 – Journal of the American Medical Association (JAMA) A U.S. cohort of 95,727 children — including those with siblings with autism — showed no link between MMR vaccination and autism risk, even in genetically predisposed children. JAMA. 2015;313(15):1534–1540 Madsen et al., 2003 – JAMA A study of 467,450 Danish children found no relationship between thimerosal-containing vaccines and autism. JAMA. 2003;290(13):1763–1766 DeStefano et al., 2022 – Vaccine A retrospective cohort of over 500,000 U.S. children with ASD found no increase in adverse events or worsening of autism-related symptoms following vaccination. Vaccine. 2022;40(16):2391–2398 2. Population-Level Epidemiologic Evidence Taylor et al., 1999 – The Lancet One of the earliest large epidemiological studies found autism prevalence was the same in vaccinated and unvaccinated children, and the age of onset was unrelated to the timing of MMR vaccination. Read: Lancet. 1999;353(9169):2026–2029 Institute of Medicine (U.S.) Immunization Safety Review, 2011 A global review of studies from the U.S., Denmark, Sweden, and the U.K. concluded there is no causal relationship between vaccination status and autism, and no plausible biological mechanism linking vaccines (including thimerosal) to ASD. Read: National Academies Press / PubMed 20669467 3. Systematic Reviews and Meta-Analyses Taylor et al., 2014 – Vaccine A comprehensive meta-analysis of 10 studies including over 1.2 million children found no association between vaccination and autism or ASD. Vaccine. 2014;32(29):3623–3629 Maglione et al., 2014 – Pediatrics Review of 67 high-quality studies covering the full U.S. immunization schedule concluded that vaccines are safe, adverse events are rare, and there is no link to autism, type 1 diabetes, or other chronic conditions. Pediatrics. 2014;134(2):325–337 Parker et al., 2004 – Pediatrics Systematic review of 10 primary studies examining thimerosal exposure found no relationship between vaccines and ASD. Authors noted that studies showing an association were methodologically flawed or biased, while robust studies consistently showed safety. Pediatrics. 2004;113(6):1904–1910 Offit & Hackett, 2003 – Clinical Infectious Diseases Review of immunology and epidemiology concluded that claims that vaccines “overwhelm” or “damage” the immune system are not biologically plausible based on how the immune system actually functions. Clin Infect Dis. 2003;46(9):1450–1456

Mind Pump Fit Tip: Is protein overrated? (2:01) Interesting People in History: Peter Freuchen. (21:41) DIY fecal transplant. (24:57) Using competition as a motivator to get healthy. (27:28) Kids say and do the darndest things. (35:43) If you could have one superpower, what would it be? (37:01) Who would win? (40:48) The dangers of snoring. (47:07) #ListenerLive question #1 – What are your thoughts on targeting visceral fat loss, especially when a person is already lean but still has visceral fat increase? (54:06) #ListenerLive question #2 – Fitness-wise, where do I need to go next? I played golf at an elite level, including three years at a high-level D-I university. (1:14:15) #ListenerLive question #3 – Where should I go after completing Transform? As a police officer working on a tactical team, I focus on strength, mobility, and resiliency. (1:21:14) #ListenerLive question #4 – Any advice on how to improve my barbell squat? (1:24:42) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit Paleovalley for an exclusive offer for Mind Pump listeners! ** Discount is now automatically applied at checkout: 15% off your first order! ** Visit Eight Sleep for an exclusive offer for Mind Pump Listeners! ** Use the code MINDPUMP to get $350 off your very own Pod 5 Ultra. The best part is that you still get 30 days to try it at home and return it if you don't like it – – Shipping to many countries worldwide. ** October Special: MAPS GLP-1 50% off! ** Code GLP50 at checkout. ** Mind Pump #2450: The Smartest Way to Use Protein to Burn Fat & Build Muscle The Impact of High Protein Diets on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies The effects of consuming a high protein diet (4.4 g/kg/d) on body composition in resistance-trained individuals Peter Freuchen: The Real Most Interesting Man In The World Woman Gets 'DIY Poop Transplant,' Ingests Pills with Brother's Fecal Matter to Combat IBS Symptoms Watch Hack Your Health: The Secrets of Your Gut - Netflix Sal Di Stefano's Journey in Faith & Fitness – Mind Pump TV Building Muscle with Adam Schafer – Mind Pump TV Justin's Road to 315 Push Press Who Would Win? 10 Book Box Set Visit Troscriptions for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP for 10% off your first order. ** Mind Pump Jobs Mind Pump #2135: Barbell Squat Masterclass Mind Pump #2350: The 4 Types of Squats Everyone Should Be Doing Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Dr. Gabrielle Lyon (@drgabriellelyon) Instagram  

Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa Today's solocast is all about Protein-Sparing Modified Fast (PSMF) days — how I've been using them in my own fat loss journey, how my approach differs from the traditional PSMF, and what the latest research says about PSMF, refeeds, and protein intake for protecting lean mass. IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That's VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. I'll be sharing: Exactly how I structure PSMF days for myself, including my research based updates on the method  How I base my approach on cutting-edge research, including the brand-new 2025 meta-analysis on protein intake and lean mass preservation during fat loss My personal results so far — how much weight I've lost since starting August 1, how it's affecting my body composition, and what's working best for me The latest studies on PSMF and refeed protocols: do refeeds really help with fat loss or just with muscle preservation and diet fatigue? Why pushing protein higher during a cut is “muscle insurance” and what the evidence says is the sweet spot for most women and men If your goal is fat loss without losing muscle, this episode is your blueprint. Get my NEW high-protein keto guide: The Keto Reset eBook Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and décolleté and get 20% OFF with the code VANESSA Free high-protein keto guide: The Keto Reset eBook