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Steatotic liver disease labels hinge on alcohol intake, but self-report is often inaccurate. In this episode, Aleksander Krag (Odense University Hospital) discusses a large Danish study using phosphatidylethanol (PEth), a direct blood biomarker of recent drinking, showing substantial underestimation and potential reclassification from MASLD to MetALD/ALD.Click here to read the full article:https://www.thelancet.com/journals/langas/article/PIIS2468-1253(25)00187-6/fulltextMedical imaging and theranostics are revolutionising how we diagnose, treat, and understand disease. To meet this moment, The Lancet group is happy to announce the launch of, The Lancet Medical Imaging and Theranostics. You can visit https://www.thelancet.com/medical-imaging-theranostics to learn more.Continue this conversation on social! Follow us today at... https://bsky.app/profile/lancetgastrohep.bsky.social https://www.linkedin.com/company/langastro/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://youtube.com/thelancettv
Most of us drink caffeine and it is in many foods too such as chocolate.What are its impact on health? In this episode I look at the pros and cons of this ubiquitous every day legal drug.Links:Genetics of caffeine metabolism: https://www.sleepmattersperth.com.au/how-genetics-influence-caffeines-impact-on-sleep/Cognitive and physical performance: https://pmc.ncbi.nlm.nih.gov/articles/PMC4462044/Caffeine and Parkinson's Disease: https://pmc.ncbi.nlm.nih.gov/articles/PMC7773776/Coffee and dementia risk: https://www.nature.com/articles/d41586-026-00409-yCoffee and Liver Disease: https://www.news-medical.net/news/20250921/Coffee-protects-the-liver-by-blocking-inflammation-and-scarring-review-finds.aspxCaffeine as pain relief: https://www.bbc.co.uk/news/articles/cgr44j201rzoSave your life in slow motion and those of others by subscribing now and sharing. Thank you for listening and for your support. It means a lot to me. Hosted on Acast. See acast.com/privacy for more information.
Send a textEvening Prayer (Salvation; Lung Disease; Liver Disease; Pain; Unborn Children)Thank you for listening, our heart's prayer is for you and I to walk daily with Jesus, our joy and peace aimingforjesus.com YouTube Channel https://www.youtube.com/@aimingforjesus5346 Instagram https://www.instagram.com/aiming_for_jesus/ Threads https://www.threads.com/@aiming_for_jesus X https://x.com/AimingForJesus Tik Tok https://www.tiktok.com/@aiming.for.jesus
Hear From Her: The Women in Healthcare Leadership Podcast Series
This episode dives into the often-overlooked intersection of hepatology and women's health. Tatyana Kushner and Andrea Goldstein share their professional journeys, from the high-intensity liver transplant units of UCLA to pioneering women's liver health programs and their personal connections to the field. The conversation focuses on the complexities of Intrahepatic Cholestasis of Pregnancy (ICP) and Primary Biliary Cholingitis (PBC), highlighting the racial disparities in diagnosis and the critical need for genetic testing. Our guests discuss the challenges of clinical trials in pregnant populations and offer a roadmap for better preconception counseling, interdisciplinary care, and the power of patient advocacy. Adding a deeply personal perspective, the host also shares her own experience with ICP, underscoring why early recognition and coordinated care are essential for protecting both maternal and fetal health. This podcast is not available for CME/CE/CPD credits. Please visit the Medscape homepage for accredited CME/CE/CPD activities.
Are the everyday products in your home silently increasing your toxic burden?In this hot health topic episode of Accelerated Health with Sara Banta, I uncover a shocking connection that could be affecting millions: Forever Chemicals and a Triple Risk of Liver Disease. I break down the latest research on PFAS (per- and polyfluoroalkyl substances)—commonly known as “forever chemicals”—and their alarming association with fatty liver disease, liver inflammation, and long-term liver dysfunction.These chemicals are found in nonstick cookware, food packaging, water-resistant fabrics, contaminated water, and even personal care products. Because they don't break down easily, they accumulate in the body over time—placing significant stress on your liver and metabolic health.If you're dealing with elevated liver enzymes, fatty liver, insulin resistance, unexplained weight gain, or chronic inflammation, this is an episode you don't want to miss.Your liver is your body's primary detox organ—and protecting it starts with awareness.Listen now as I uncover what you need to know to lower your toxic exposure, support your liver, and take control of your health.Supplements Featured In This Episode:• Accelerated Liver Care® https://www.acceleratedhealthproducts.com/products/accelerated-liver-care • Accelerated Cellular Detox® Powder https://www.acceleratedhealthproducts.com/products/accelerated-cellular-detox-powder • Acceleradine® Iodine https://www.acceleratedhealthproducts.com/products/acceleradine-iodine-supplement • BodyBio PC (Phosphatidylcholine) https://www.acceleratedhealthproducts.com/products/bodybio-pc-phosphatidylcholine • Accelerated Ancient Salt® https://www.acceleratedhealthproducts.com/products/accelerated-ancient-salt-4-oz • Accelerated Liver Flush Detox Cleanse https://www.acceleratedhealthproducts.com/products/liver-detox-cleanse Not sure what food to eat and avoid? This guide is for you.⬇️
In this episode we discuss alcohol-related liver disease (ARLD), what it is, its treatment, and hear Lesley's experience as a survivor of ARLD and transplant. Lesley was a patient of Dr Ashwin Dhanda, a liver specialist, and both provide their insights into the condition and how society should do more to raise awareness of and prevent alcohol-related harm and ARLD.Ashwin Dhanda is Professor of Liver Medicine at the University of Plymouth and a liver specialist at University Hospitals Plymouth NHS Trust. He leads a programme of research around stigma in alcohol-related liver disease including identifying causes of stigma and how it affects people and designing interventions to tackle it.Lesley was diagnosed with ARLD in December 2019, which led to a liver transplant in December 2019. She is part of a liver support group supporting other patients and working as a patient representative with Ashwin on a research project around stigma in alcohol related liver disease and helping the research team design interventions to tackle it from a patient/peer perspective.Support the showIf you are interested in one-to-one support for your drinking with Dr James Morris, contact him at DrJamesMorris.com Sign up to receive new episodes to your inbox here. For more episodes visit https://alcoholpodcast.buzzsprout.com/Follow us on Instagram
Your poop can reveal early warning signs of serious health issues long before symptoms appear. In this episode, Ben Azadi explains how stool color, texture, and consistency reflect what's happening in your gut, liver, and metabolism. Ben breaks down three major red flags to watch for: pale or clay-colored stool linked to poor bile flow and liver dysfunction, black or tar-like stool that may indicate internal bleeding, and mucus or blood in the stool as a sign of chronic gut inflammation or damage. You'll learn why colon cancer, liver disease, and gut disorders often develop silently, how bile supports fat digestion, detoxification, and hormone balance, and why “feeling fine” doesn't always mean your body is healthy. The episode also covers practical steps to reduce inflammation, support liver health, improve bile flow, and restore healthy digestion through nutrition, lifestyle changes, and proper elimination. This conversation is about awareness, not fear, empowering you to recognize patterns early and take action before small signals turn into serious health problems.
In this special edition episode of Liver Lineup, recorded as part of HCPLive's This Year in Medicine series, hosts Nancy Reau, MD, and Kimberly Brown, MD, break down the most consequential updates of the year across primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH), highlighting data that may reshape both near-term management and longer-term treatment strategies.Key episode timestamps:0:00:00 – Intro0:00:40 – Underuse of second‑line therapy in PBC0:03:40 – Long‑term data on PPAR agonists (elafibranor, seladelpar) in PBC0:09:35 – PSC: elafibranor (Elmwood trial) and CCL24 mAb (nabokitug)0:15:56 – Cholestasis symptoms: fatigue and pruritus and PPAR impact0:20:20 – Autoimmune hepatitis: limitations of current therapy; new agent
In this episode of Liver Lineup: Updates and Unfiltered Insights, hosts Nancy Reau, MD, and Kimberly Brown, MD, are joined by guest Jessica Mellinger, MD, to discuss rising prevalence, new care models, and evolving concepts in alcohol-associated liver disease (ALD).Key episode timestamps:0:00:00 – Introduction0:00:30 – Prevalence of alcohol use & ALD under-recognition0:04:22 – Origin and design of the integrated ALD clinic0:06:50 – Expansion and outcomes of integrated care0:10:33 – Workforce and access challenges0:12:21 – Metabolic ALD (MetALD) concept0:15:18 – GLP‑1 agonists for metabolic disease & AUD0:19:09 – “Food noise,” food addiction, and ultra‑processed foods0:22:38 – Liver transplantation in ALD & Dallas criteria0:27:27 – Outcomes after relapse & closing
Liver disease isn't just about alcohol, and it's way more common than most people realize. In this episode of The Gut Show, @socalgastrodoc helps break down what your liver actually does, why cases are rising, how it's diagnosed, what's reversible, and where things like GLP-1s, supplements, and even coffee fit in. If you've ever been told to "just drink less" or felt overwhelmed by perfection, this one's for you! About our guest: Dr. Wendi LeBrett is a double board-certified gastroenterologist and internal medicine physician. She holds a Bachelor of Arts in Economics from Stanford University and graduated from the University of California San Diego School of Medicine. She completed her internal medicine residency and gastroenterology subspecialty fellowship at UCLA. Her research has been published in several leading gastroenterology journals including Gastroenterology, The American Journal of Gastroenterology, Clinical Gastroenterology & Hepatology, and The Lancet Gastroenterology. Dr. LeBrett is a leading voice in gastroenterology on social media. She presented the presidential plenary at United European Gastroenterology Week 2025 on medical misinformation on social media and was awarded a Healio Gastroenterology Disruptor award as Social Media Influencer of the Year 2023. She has over 300K followers on social media and creates educational content as @socalgastrodoc. She is a trusted voice on gastrointestinal health and has been featured in the Wall Street Journal, TIME, SELF, the Huffington Post, Business Insider and Well+Good. She is the founder of ModernGut, a gastroenterology education platform. TikTok Instagram Thank you to our partners: @imodifyhealth is the leader in evidence-based, medically-tailored meal delivery offering Monash Certified low FODMAP, Gluten free, and Mediterranean meals - expertly crafted to help you achieve better symptom control AND improve overall health. The best part? They make it easy by doing all prep work for you. Simply choose the meals you want, stock your fridge or freezer when meals arrive at your door, then heat and enjoy when you're ready. Delicious meals. Less stress. Complete peace of mind. Check out modifyhealth.com and save 35% off your first order plus free shipping across the US with code: THEGUTSHOW. @fodzyme is the world's first enzyme supplement specialized to target FODMAPs. When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues. With FODZYME, enjoy garlic, onion, wheat, brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss. Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer. @mbiotaelemental is the next generation of the elemental diet. Developed with leading gastroenterologists and food scientists, it's the first formula that's both clinically effective AND genuinely easy to drink. If you're looking for an option to support SIBO or your gut, mBIOTA Elemental may be one to consider. Learn more at mbiota.com and save 20% on their two-week protocol with code GUTIVATE
In this final episode, Vallier explores the next steps for liver regeneration research, including stimulating liver regeneration with small molecules and lifestyle factors. He describes AI as a tool that should not be used in the wrong way, before wrapping up the discussion with his predictions for the next 5 years and the introduction of induced pluripotent stem cell clinical trials. Timestamps:00:55 – Research beyond organoids 02:01 – Lifestyle factors 03:47 – Research funding 04:13 – AI in biotechnology 05:13 – Future of regenerative medicine 07:04 – Vision for stem cell therapies
Robotic-assisted surgery has been introduced at the Health Authority. The equipment has already been used in five hernia operations, and opens the doors for its use in further procedures. Christina Cortes has been following this story. January is cervical cancer awareness month. It's a time to learn more about prevention, detection, and that all important screening. Dr Olivia Gonzalez and Michelle Brown from the GHA talking about this very common cancer.How a rare diagnosis can change your life: Kevin Davis talked about his journey since was diagnosed with Polycystic Liver disease at the age of 35, and how he's raising funds and awareness for others with the same condition.And the weather has been causing chaos today, from traffic jams to furniture flying off balconies, Iain Triay Clarence has been weather-watching for us. Hosted on Acast. See acast.com/privacy for more information.
Malnutrition in hospitalized patients is common, costly, and often missed—especially in those with complex disease states. In this episode, we take a clinically focused look at how dietitians can better identify malnutrition in liver disease and why early, accurate diagnosis matters for patient outcomes.Our guest is Dr. Janette Hasse, a nationally recognized expert in critical care and transplant nutrition, FNCE presenter, longtime Editor-in-Chief of Nutrition in Clinical Practice, award-winning clinician, and leader of a large transplant nutrition team. With more than four decades of experience, she breaks down the evidence and real-world considerations shaping malnutrition diagnosis today.We discuss:✔ Why patients with liver disease are uniquely vulnerable to malnutrition✔ Limitations of traditional assessment methods in complex populations✔ The emerging role of CT imaging for body composition analysis✔ How updated GLIM criteria and terminology changes are impacting practice✔ Confusion around using AAIM vs GLIM and how clinicians can navigate both✔ Practical documentation strategies for care and reimbursement✔ Actionable clinical pearls for bedside dietitiansWhether you work inpatient, outpatient, transplant, GI, or critical care, this episode offers insight into how dietitians can strengthen the diagnostic process and advocate for better nutrition care.Listen now and access additional resources at dnsdpg.org.
Welcome to Episode 52 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! NSAIDs National Institutes of Health. (2022). Nonsteroidal antiinflammatory drugs. LiverTox: Clinical and research information on drug-induced liver injury. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK548614/ LFTs / Drug-Induced Liver Injury American Association for the Study of Liver Diseases. (2023). Practice guidance on drug, herbal, and dietary supplement–induced liver injury. Hepatology. Retrieved from https://journals.lww.com/hep/fulltext/2023/03000/aasldpracticeguidanceondrug,herbal,and.28.aspx Toxicology Screening StatPearls Publishing. (2023). Toxicology screening. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK499901/ Academy of Diagnostic & Laboratory Medicine. (2023). Testing for drugs of misuse to support the emergency department. Retrieved from https://myadlm.org/science-and-research/academy-guidance/testing-for-drugs-of-misuse-to-support-the-emergency-department CT Utilization / Imaging American College of Emergency Physicians. (2022). The renewed necessity of robust clinical judgment in CT scan utilization. ACEP Now. Retrieved from https://www.acepnow.com/article/the-renewed-necessity-of-robust-clinical-judgment-in-ct-scan-utilization/ Appropriate Testing / Overuse Context Melnick, E. R., et al. (2023). GRACE-2: Guidelines for reasonable and appropriate care in the emergency department. Academic Emergency Medicine. Retrieved from https://onlinelibrary.wiley.com/doi/10.1111/acem.14495 More from us: Our CME courses: EM Boot Camp: https://courses.ccme.org/course/embootcamp/about EM Boot Camp Pharmacology Workshop: https://bit.ly/2I44xld Bouncebacks! Medical & Legal: https://courses.ccme.org/education/bouncebacks-medical-and-legal Mastering Emergency Imaging: https://courses.ccme.org/education/mastering-emergency-imaging Advanced EM Boot Camp: https://courses.ccme.org/course/advancedbootcamp/about Advanced ECG Workshop: https://bit.ly/aembc-ecg Advanced Imaging Workshop: https://bit.ly/aembc-imaging EM & Acute Care: https://courses.ccme.org/course/ema/about National EM Board Review: https://courses.ccme.org/course/nembr/about High Risk Emergency Medicine: https://courses.ccme.org/course/hrem The Heart Course: https://courses.ccme.org/course/theheartcourse The Cadaver-Based Procedures & Suturing Courses: https://courses.ccme.org/course/cadaver EM:Prep LLSA Review: https://courses.ccme.org/course/em-prep/about EMCert Module Mastery: https://courses.ccme.org/course/emcertmodule USC Trauma Course: https://courses.ccme.org/course/usc-trauma ACOEP Scientific Assembly: https://courses.ccme.org/course/acoep Mastering Acute Care Charting - 2023 Updates: https://courses.ccme.org/course/macc Flourishing in Medicine: https://courses.ccme.org/course/flourishing-in-medicine The DEA Licensee SUD Training Course: https://courses.ccme.org/course/dea ACOFP On-Demand: https://courses.ccme.org/education/acofp25-clinical-selects The Airway and Lung Course: https://courses.ccme.org/education/airway Mastering Pediatric Emergencies: https://courses.ccme.org/course/pediatric-em Innovations in ED Management: https://courses.ccme.org/course/innovationsined American Osteopathic Association Courses: https://aoa.coursehost.net EM Cases Summit: https://courses.ccme.org/education/em-cases-summit-2024 IncrEMentuM Conference – On-Demand: https://courses.ccme.org/education/incrementum-2025 Our social media: TikTok: https://www.tiktok.com/@ccmecourses Instagram: https://www.instagram.com/ccmecourses Facebook: https://www.facebook.com/CenterForMedicalEducation LinkedIn: https://www.linkedin.com/in/rickbukata Our podcasts: The 2 View Podcast (Free): Subscribe on Apple Podcasts https://apple.co/3rhVNZw Subscribe on Google Podcasts: http://bit.ly/2MrAHcD Subscribe On Spotify: http://spoti.fi/3tDM4im Risk Management Monthly Podcast (Paid CME): https://www.ccme.org/riskmgmt ** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. The information in this video is for informational purposes only and not for the purpose of providing legal advice. You should contact your attorney to obtain advice with respect to any particular issue or problem. Nothing here should be construed to form an attorney-client relationship. ** emergencymedicine #cme
Send us a textEvening Prayer - Goodness of God, Liver Disease, People Struggling With ShameThank you for listening, our heart's prayer is for you and I to walk daily with Jesus, our joy and peace aimingforjesus.com YouTube Channel https://www.youtube.com/@aimingforjesus5346 Instagram https://www.instagram.com/aiming_for_jesus/ Threads https://www.threads.com/@aiming_for_jesus X https://x.com/AimingForJesus Tik Tok https://www.tiktok.com/@aiming.for.jesus
Physician-scientist Randall Stafford studies the effects of alcohol use on population health – the true health impact, he emphasizes. Stafford explains how early research suggested that drinking is beneficial – or at least not bad – for people. That mindset produced decades of wishful thinking based on inconsistent science driven by social, emotional, and industry forces. The small cardiovascular benefits, he says, are far outweighed by the risks of cancer, liver disease, depression, and other ills. Although the harms of low-level consumption are small, there is no safe level of alcohol use, Stafford tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Randall StaffordConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Randall Stafford, a professor of medicine at Stanford University.(00:03:35) Challenges in Alcohol ResearchWhy cultural norms and study limitations complicate evidence.(00:03:56) Historical Perspectives on DrinkingHow early studies suggested benefits and why those conclusions shifted.(00:09:12) Risk, Dose, and Drinking PatternsThe increased risks with binge drinking and higher doses of alcohol.(00:12:15) Health Benefits vs. Lifestyle EnjoymentClarifying what alcohol does—and does not—provide medically.(00:13:37) Alcohol and Mental HealthThe bidirectional effects between alcohol use and mental health.(00:17:37) Broader Mental and Social EffectsAlcohol's connection to bipolar disorder, unemployment, and social harm.(00:20:12) How Alcohol Myths PersistWhy simplified conclusions endured despite contradictory data.(00:22:46) Changing Cultural AttitudesCultural trends toward reduced drinking and alcohol-free periods.(00:25:49) Alcohol and Liver DiseaseThe effects of alcohol beyond heavy use, including metabolic disease.(00:27:29) Strategies to Reduce HarmWay to reduce alcohol consumption and avoid binge drinking.(00:29:25) Future In a MinuteRapid-fire Q&A: avoiding alcohol, research needs, and studying liver disease.(00:31:04) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Chris Burns was a successful cinematographer and director of photography for multiple Emmy-winning projects. Then he developed significant alcohol-associated liver disease which eventually led him to a liver transplant. He is now two years post transplant and is working on a documentary to raise awareness for both liver disease and liver transplantation. We discuss his journey and his advocacy work in today's episode of the Gut Doctor Podcast. This episode is brought to you by Mindray and Aegle Medical, manufacturer and distributor of the Hepatus-series platform, which is a NexGen vibration-controlled elastography technology used to stage and monitor liver disease.
Nutritionist Leyla Muedin discusses the renaming of fatty liver disease to metabolic dysfunction-associated steatotic liver disease (M-A-S-L-D) to reduce stigma and improve diagnosis. Dr. Mary Ella's efforts at the University of Chicago Medicine highlight how this change aids in better patient identification and treatment. Leyla emphasizes lifestyle changes like a low-carb diet to manage and reverse the disease. The episode also covers the prevalence of fake extra virgin olive oil (EVOO) on the market, ways to identify authentic olive oil, and the importance of choosing quality over mass-produced options.
Program notes:0:40 IVF clinics and private equity1:40 Provide over 54% of all IVF cycles in U.S.2:41 Perhaps a more positive result3:30 EKGs and liver cirrhosis4:30 New diagnosis of advanced liver disease5:30 Most physicians didn't follow up6:18 Management of acute back pain7:18 Did it improve pain or disability?8:18 Four- to eight-hour-long sessions to teach8:46 Lay health worker led intervention for older adults with cancer9:46 Reviewed with advanced practice practitioners10:46 Huge benefit from modest intervention11:46 Pick up the phone and ask12:20 Modest outlay13:09 End
Don't miss out — elevate your skills and save $100 on any online course with code START26! Join our library of live and on-demand veterinary dental courses here: https://internationalveterinarydentistryinstitute.org/veterinary-dental-online-webinars-courses-discount/?utm_source=podcast&utm_medium=podcastlink&utm_campaign=start26 —------------------------------------------------------------------- Host: Dr. Brett Beckman, DVM, FAVD, DAVDC, DAAPM In this episode of The Vet Dental Show, Dr. Victoria Lukasik, DVM, DACVAA, tackles the complexities of managing high-risk dental cases. Through detailed case studies, they discuss anesthetic protocols for patients with hepatic portal shunts and chronic heart failure. Learn how to navigate potential complications like hypoglycemia, hemorrhage, and ventricular tachycardia, while ensuring patient safety and optimizing recovery. What You'll Learn: ✅ Understand anesthetic considerations for patients with hepatic portal shunts. ✅ Discover strategies for managing hypoglycemia and electrolyte imbalances. ✅ Simplify anesthetic protocols for patients with chronic heart failure. ✅ Apply techniques for recognizing and treating ventricular tachycardia. ✅ Master the use of short-acting and reversible drugs in high-risk patients. ✅ Recognize and address delayed recovery in the post-anesthetic period. Key Takeaways: ✅ Patients with hepatic portal shunts require short-acting, reversible drugs to minimize liver burden. ✅ Intermittent hemorrhage in patients with hepatic dysfunction may lead to platelet consumption and anemia. ✅ Bounding femoral pulses can indicate dehydration; adjust fluid therapy accordingly in cardiac patients. ✅ Lidocaine has centrally depressing effects; anticipate mental dullness or sedation post-administration. ✅ Early intervention with lidocaine is crucial for managing ventricular tachycardia and preventing further complications. Questions This Episode Answers: ❓ How should anesthetic protocols be adjusted for patients with hepatic portal shunts? ❓ Which anesthetic and analgesic drugs are safest for patients with true hepatic dysfunction? ❓ When should dextrose supplementation be considered in dental patients with liver disease? ❓ How do you manage intermittent hemorrhage, anemia, and low platelets during dental procedures? ❓ What causes delayed anesthetic recovery—and how do you systematically troubleshoot it? ❓ How should cardiac medications be handled on the morning of anesthesia for heart failure patients? ❓ What do bounding femoral pulses indicate, and how should fluid therapy be adjusted? ❓ Why can lidocaine cause deep sedation and delayed recovery after anesthesia? ❓ How do you recognize ventricular tachycardia intraoperatively—and when should you intervene? ❓ What recovery expectations should you have after treating ventricular tachycardia with lidocaine? —------------------------------------------------------------------- Explore Dr. Beckman's complete library of veterinary dentistry courses and CE resources! Save $100 on any online course with code START26! https://internationalveterinarydentistryinstitute.org/veterinary-dental-online-webinars-courses-discount/?utm_source=podcast&utm_medium=podcastlink&utm_campaign=start26 —------------------------------------------------------------------- Questions? Leave a comment below with your thoughts, experiences, or cases related to veterinary dentistry! —------------------------------------------------------------------- KEYWORDS: Veterinary Dentistry, IVDI, Brett Beckman, Dog Dental Care, Cat Dental Care, VetTech Tips, Animal Health, Veterinary Education, Veterinary Dental Practitioner Program, Vet Dental Show, Anesthesia, High-Risk Patients, Hepatic Portal Shunt, Chronic Heart Failure, Ventricular Tachycardia, Lidocaine, Hypoglycemia, Electrolyte Imbalance, Delayed Recovery
Kris V. Kowdley, MD - Advancing the Management of Cholestatic Liver Disease: Optimizing Treatment Pathways and Novel Therapies
Kris V. Kowdley, MD - Advancing the Management of Cholestatic Liver Disease: Optimizing Treatment Pathways and Novel Therapies
BioVie CEO Cuong Do joined Steve Darling from Proactive to provide an update on the company's recent progress across its two lead drug candidates, Bezisterim and BIV201, as BioVie positions itself for multiple clinical and regulatory catalysts in 2026. Bezisterim, an anti-inflammatory compound that blocks tumor necrosis factor alpha (TNF-α), is being evaluated across several indications, including Parkinson's disease, long COVID, and Alzheimer's disease. Do highlighted that the compound has delivered encouraging signals in prior studies, including improvements in muscle control and cognitive function, as well as evidence suggesting a slowing of biological aging. Building on these results, BioVie has launched a new clinical trial enrolling 60 patients with earlier-stage Parkinson's disease to evaluate Bezisterim as a standalone therapy. The goal of the study is to assess the drug's potential disease-modifying effects when administered earlier in the disease course. Topline data from this trial are expected in April or May of 2026. In parallel, BioVie is advancing a separate, larger clinical program targeting long COVID. The company is conducting a 200-patient trial designed to evaluate Bezisterim's ability to address persistent inflammatory mechanisms believed to drive many long COVID symptoms. Enrollment for this study is expected to be completed by February 2026. The trial is supported by a $13 million grant awarded to BioVie, underscoring the growing recognition of inflammation as a key contributor to long COVID. Do also provided an update on BioVie's second lead candidate, BIV201, which is being developed to treat ascites associated with late-stage liver disease. The company's Phase 2 trial of BIV201 was stopped early after interim data showed the drug reduced fluid accumulation by more than 50%, a clinically meaningful outcome in a difficult-to-treat patient population. Following discussions with the U.S. Food and Drug Administration, BioVie has now received feedback and authorization to advance BIV201 directly into a single Phase 3 clinical trial, streamlining the development pathway. Looking ahead, Do emphasized that BioVie expects 2026 to be a transformational year, with multiple clinical data readouts across programs and the potential initiation of a pivotal Phase 3 study. “2026 will be a big catalyst year for us,” he said, highlighting the breadth of opportunities across the company's pipeline. proactiveinvestors #biovieince #nasdaq #bivi #alzheimersdisease #dementia #Alzheimers #Dementia #NeurodegenerativeDiseases #BrainHealth #BioVie #CognitionImprovement #Neuroinflammation #SocialImpact #DementiaAwareness #ElderlyCare #Neuroscience #MemoryImprovement #AlzheimersResearch #HealthCrisis #DementiaSupport #BrainScience #GlobalHealth #AlzheimersSolution #Caregivers #HealthyAging #MentalHealth #MedicalResearch #DementiaPrevention #Neurology #WorldAlzheimersDay #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews
Kris V. Kowdley, MD - Advancing the Management of Cholestatic Liver Disease: Optimizing Treatment Pathways and Novel Therapies
Kris V. Kowdley, MD - Advancing the Management of Cholestatic Liver Disease: Optimizing Treatment Pathways and Novel Therapies
Dr. Venkat Katapatna breaks down the newly adopted MASLD nomenclature and its implications for diagnosing and managing metabolic dysfunction–associated steatotic liver disease. He highlights updated AASLD guidelines, the expanding role of advanced imaging, and how radiologists are central to early detection, treatment selection, and longitudinal disease monitoring. Current Update on Nomenclature, Diagnosis,and Management of Metabolic Dysfunction–associated Steatotic Liver Disease:Radiologists' Perspective. Osta et al. RadioGraphics 2025; 45(12):e240221.
Claim your complimentary gift of my exclusive mini weight care guide today!Link: Weight Care Guide — Dr. Francavilla Show (thedrfrancavillashow.com)Ever wonder how much your liver really affects your overall health and weight? The liver plays a central role in metabolism, yet its importance is often underestimated.In this week's episode, we spoke with Dr. Rajvanshi, a board-certified gastroenterologist, hepatologist, and obesity medicine specialist at Valley Medical Center in Riten, Washington. Beyond his clinical practice, he's a health technology entrepreneur, developing AI tools to support obesity medicine for both clinicians and patients, and he is actively involved in the Obesity Medicine Association.Topics we covered include:The Liver: More Than a Detox OrganLiver Damage Can Be ReversedFatty Liver to Fibrosis: What You Need to KnowWhy Fatty Liver Screening Is EssentialSupplements vs. Real Nutrition for Liver HealthAlcohol's Impact on Your LiverModern Treatments: Resmetirom, Semaglutide, and Liver HealthMany people think of the liver simply as the body's detoxifier, but it's far more complex and vital. It supports metabolism, nutrient processing, and overall health. Understanding and maintaining liver health is key to long-term wellness, especially when it comes to weight management and metabolic health.Dr. Rajvanshi's approach highlights a modern principle in medicine: treat the root causes, not just the symptoms. By addressing liver care alongside metabolic health and obesity medicine, clinicians can help patients prevent serious complications, reduce the need for invasive treatments, and improve quality of life.For a deeper dive into how these insights translate into real-life health and weight outcomes, the full conversation is well worth a listen.Connect with Dr. Rajvanshi.:LinkedIn: Pankaj Rajvanshi, MD, Dipl. ABOMConnect with me:Instagram: doctorfrancavillaFacebook: Help Your Patients Lose Weight with Dr. FrancavillaWebsite: Dr. Francavilla ShowYoutube: The Doctor Francavilla ShowGLP Strong: glpstrong.com
Mardi Dier, CFO of Madrigal Pharmaceuticals (MDGL), spotlights their latest quarter and the launch of their first product. Their drug treats liver disease (specifically MASH), and she says they are already on track for $1 billion in sales. Mardi also highlights their strong balance sheet, international expansion, and an extended patent. She stresses that there are millions of patients living with MASH, and there are few other therapies in the field. ======== Schwab Network ========Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/ About Schwab Network - https://schwabnetwork.com/about
This week on Health Matters, Courtney sits down with Dr. Braden Kuo, Chief of the Division of Digestive & Liver Diseases at NewYork-Presbyterian and Columbia. Dr. Kuo covers common gut problems during the holiday season, a time of indulgent meals and treats. From bloat to heartburn to travel-related stomach issues, Dr. Kuo is a trove of information and practical tips for navigating holiday festivities with good choices for your gut. ___ Dr. Braden Kuo is a leading neurogastroenterologist specializing in gastrointestinal motility and the relationship between the brain, nervous system and digestive system. He is the Chief of the Division of Digestive and Liver Diseases at NewYork-Presbyterian/ColumbiaUniversity Irving Medical Center and Columbia University Vagelos College of Physicians andSurgeons. Dr. Kuo received his medical degree from Jefferson Medical College and completed his residency at the University of Texas Southwestern Medical Center before arriving at Massachusetts General Hospital, where he served as director of the Center for Neurointestinal Health. He also completed formal training in clinical research, earning a Master of Science from the Harvard T.H. Chan School of Public Health, and subspecialty training in neurogastroenterology and motility at Mayo Clinic.___Health Matters is your weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine.To learn more visit: https://healthmatters.nyp.org
In this weekly roundup, JAMA Medical News Director Jennifer Abbasi and Lead Senior Staff Writer Rita Rubin discuss "MASLD—The Chronic Liver Disease That Affects Tens of Millions of US Adults but Flies Under the Radar" and more. Related Content: Metabolic Dysfunction–Associated Steatotic Liver Disease in Adults MASLD—The Chronic Liver Disease That Affects Tens of Millions of US Adults but Flies Under the Radar ------------------------ jamamedicalnews.com
This week on Health Matters, Courtney talks with Dr. Robert Brown, the chief of gastroenterology and hepatology at NewYork-Presbyterian and Weill Cornell Medicine, to discuss the benefits and risks of taking dietary supplements, for our liver and our overall health. Dr. Brown offers tips for deciding which supplements to take, which to avoid, and ways we can optimize our liver health. ___Dr. Robert Brown is an expert in liver diseases, including alcohol-related liver disease, which affects up to 20 percent of the population, chronic hepatitis C infection, which affects an estimated 2.4 million Americans and cirrhosis, a scarring of the liver that is the third most common disease-related cause of death in the United States. He co-founded the Center for Liver Disease and Transplantation at NewYork-Presbyterian/Weill Cornell Medical Center, a joint program with Columbia University Irving Medical Center, in 1998. Dr. Brown will continue as medical director of this program, the largest for liver transplantation in New York City.___Health Matters is your weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine.To learn more visit: https://healthmatters.nyp.org
In this episode, we review the high-yield topic of Alcoholic Liver Disease from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this essential episode of Parallax, Dr Ankur Kalra welcomes Dr Monica Tincopa, Assistant Professor of Medicine at the University of California San Diego, for a crucial conversation about Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and its profound implications for cardiovascular care. Dr Tincopa guides listeners through the recent transformation from NAFLD to MASLD, explaining why this nomenclature change represents more than just terminology, instead reflecting a deeper understanding of metabolic health that directly impacts cardiology practice. The conversation explores practical screening strategies that cardiologists can implement immediately, including the use of FIB-4 risk stratification and recognizing incidental findings on cardiac imaging. Dr Tincopa shares insights on when to refer patients to hepatology specialists and how the shared risk factors between MASLD and cardiovascular disease create opportunities for comprehensive patient care. This episode equips cardiologists with essential knowledge to identify at-risk patients within their existing practice, understand the cardiovascular implications of liver disease, and optimize care coordination for patients with overlapping metabolic conditions. Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.
In this episode, Dr. David Traster sits down with Dr. Michael Lebowitz, DC and Dr. Noah Lebowitz, DC of Supreme Nutrition Products to uncover what's really driving the chronic disease epidemic — and how herbal medicine + integrative strategies can help turn the tide.
Here is a real-world clinical case with a tricky differential: Our team recently readmitted a patient 6 days postpartum/post C-section (which was done for ICP and fetal macrosomia at close to 4500 grams, with A2GDM). She had elevated blood pressures, a frontal headache, some midepigastric pain/RUQ discomfort. Pretty clear picture right: sounds like preeclampsia (PreE) with severe features based on BP elevation and symptoms. So, we started her on mag-sulfate per protocol. Well, her transaminases were in the 400-600s, which was significantly higher than they were at delivery. They then peaked the next day at 900! OK, it still meets criteria for PreE with severe features. But could this also be postpartum Acute fatty Liver of Pregnancy (AFLP)? The clinical picture of these 2 conditions may overlap but there are distinct differences here. AFLP is potentially fatal, so we have to get that diagnosis correct. How can we distinguish AFLP from PreE with severe features or HELLP? Listen in for details.1. https://www.preeclampsia.org/the-news/health-information/acute-fatty-liver-of-pregnancy-can-be-confused-with-preeclampsia-and-hellp-syndrome2. Yemde A Jr, Kawathalkar A, Bhalerao A. Acute Fatty Liver of Pregnancy: A Diagnostic Challenge. Cureus. 2023 Mar 26;15(3):e36708. doi: 10.7759/cureus.36708. PMID: 37113350; PMCID: PMC10129069.3. Maalbi O, Elachhab N, Elkabbaj A, Arfaoui M, Hindi S, Lahbabi S, Oudghiri N, Tachinante R. Management of Acute Fatty Liver of Pregnancy: A Retrospective Study of 12 Cases Compared With Data in the Literature. Cureus. 2025 Jun 11;17(6):e85753. doi: 10.7759/cureus.85753. PMID: 40656400; PMCID: PMC12247011.4. Siwatch S, De A, Kaur B, et al. Safety and Efficacy of Plasmapheresis in Treatment of Acute Fatty Liver of Pregnancy-a Systematic Review and Meta-Analysis.Frontiers in Medicine. 2024;11:1433324. doi:10.3389/fmed.2024.1433324.5. Sarkar M, Brady CW, Fleckenstein J, et al.6. Reproductive Health and Liver Disease: Practice Guidance by the American Association for the Study of Liver Diseases.Hepatology (Baltimore, Md.). 2021;73(1):318-365. doi:10.1002/hep.31559.STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG
Today's guest is Tony Villiotti, founder of Liver Education Advocates, a non-profit with the mission of increasing public awareness and providing education regarding nonalcoholic liver disease. He is also a survivor of liver cancer and the beneficiary of a life-saving liver transplant.We talk all about liver disease, from diabetes to fatty liver, cirrhosis and cancer, the risk factors of all, how important it is to be monitored if you have diabetes, Tony's mission to educate the public about liver disease, lifestyle habits, and so much more!!Poor lifestyle habits can send you down this road and the symptoms are sometimes silent. This is a great reminder of how important it is to take care of your health. Resources:Websites: www.liveradvocates.org and www.higadograso.orgLinkedin: https://www.linkedin.com/company/livereducationadvocates/Instagram: https://www.instagram.com/loveyourliver1/Facebook: https://www.facebook.com/LiverEducationAdvocates YouTube: https://www.youtube.com/@LoveYourLiver1Follow:Follow me: https://www.instagram.com/melissagrosboll/My website: https://melissagrosboll.comEmail me: drmelissagrosboll@gmail.com
In this episode, we review the high-yield topic Alcoholic Liver Disease from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, Joy Tomlinson, DVM, PhD, DACVIM (LAIM), joined us to discuss common liver diseases in horses, including EqPV-H and EqHV. She talked about clinical signs of liver disease, diagnostic strategies, treatment and management options, biosecurity considerations, and more. This episode of Disease Du Jour is brought to you by Bimeda. GUESTS AND LINKS - EPISODE 167Host: Carly Sisson (Digital Content Manager) of EquiManagement | Email Carly (CSisson@equinenetwork.com)Guest: Joy Tomlinson, DVM, PhD, DACVIM (LAIM)Podcast Website: Disease Du JourThis episode of Disease Du Jour podcast is brought to you by Bimeda.Connect with the Host: Carly Sisson (Digital Content Manager) of EquiManagement | Email Carly (CSisson@equinenetwork.com)
In this episode, Joy Tomlinson, DVM, PhD, DACVIM (LAIM), joined us to discuss common liver diseases in horses, including EqPV-H and EqHV. She talked about clinical signs of liver disease, diagnostic strategies, treatment and management options, biosecurity considerations, and more. This episode of Disease Du Jour is brought to you by Bimeda. GUESTS AND LINKS - EPISODE 167Host: Carly Sisson (Digital Content Manager) of EquiManagement | Email Carly (CSisson@equinenetwork.com)Guest: Joy Tomlinson, DVM, PhD, DACVIM (LAIM)Podcast Website: Disease Du JourThis episode of Disease Du Jour podcast is brought to you by Bimeda.Connect with the Host: Carly Sisson (Digital Content Manager) of EquiManagement | Email Carly (CSisson@equinenetwork.com)
Please visit answersincme.com/WTR860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, experts in hepatology and endocrinology discuss the impact of obesity on liver disease progression, current and emerging GLP-1 receptor agonist therapies, and strategies to optimize clinical outcomes in metabolic dysfunction-associated steatohepatitis (MASH). Upon completion of this activity, participants should be better able to: Identify how obesity impacts metabolic dysfunction–associated steatohepatitis (MASH) progression and liver health; Review current and emerging glucagon-like peptide-1 (GLP-1) receptor agonist (RA)–based therapies for the treatment of MASH; and Outline approaches to optimize patient outcomes in obesity-related liver disease.
What happens when alcohol use and metabolic factors collide? In Part 2, Stephanie Rutledge explains how alcohol-related liver disease develops, the challenges of holistic care, and the evolving role of liver transplantation. A must-listen for clinicians navigating the complexities of metabolic dysfunction and alcohol-related liver disease, and patient-centred management. Timestamps: 0:21 – Metabolic dysfunction and alcohol-related liver disease (MetALD) 3:45 – Treatments for liver disease 5:49 – Mental health considerations 6:36 – Family support 7:51 – Factors beyond clinical treatment
For weight loss, complete avoidance of ultra-processed foods outperforms mere “healthy diet” comprising minimally-processed items; Research fraud undermines anti-dementia drug pipeline; Comprehensive lifestyle modification program scores against cognitive decline; Women's brains especially vulnerable to Omega-3 deficiencies; Bible says “Lame shall walk again” and 21st century science may soon bring about this miracle; Breakthroughs in rheumatoid arthritis treatment.
This week Bobbi Conner talks with MUSC's Dr. Don Rockey about the causes, treatment, and prevention of alcohol-related liver disease.
This Day in Legal History: Nineteenth Amendment RatifiedOn August 18, 1920, the Nineteenth Amendment to the U.S. Constitution was ratified, guaranteeing women the right to vote and marking a major legal milestone in the struggle for gender equality. The amendment states simply: “The right of citizens of the United States to vote shall not be denied or abridged… on account of sex.” Its passage capped off more than 70 years of organized activism, dating back to the Seneca Falls Convention in 1848. Suffragists like Susan B. Anthony, Elizabeth Cady Stanton, Sojourner Truth, and Alice Paul played pivotal roles in maintaining momentum across generations, despite fierce opposition.The road to ratification was grueling. Congress passed the amendment in 1919, but it still required approval from three-fourths of the states—36 at the time. Tennessee became the critical 36th state, narrowly approving the amendment in a dramatic vote where a 24-year-old legislator, Harry T. Burn, changed his vote after receiving a letter from his mother urging him to support suffrage. That moment tipped the scales and enshrined the right to vote for women nationwide.Before the amendment, several western states had already extended suffrage to women, but many others actively suppressed it. The legal recognition of women's voting rights through constitutional amendment removed any ambiguity and forced all states to comply. The Nineteenth Amendment not only transformed the electorate but also reshaped American democracy by recognizing women as full political participants.The Trump administration is accusing a federal judge in Boston of undermining the authority of the U.S. Supreme Court by continuing to block the administration from firing staff in the Department of Education's Office for Civil Rights. U.S. District Judge Myong Joun had issued an injunction requiring the reinstatement of employees let go in a mass layoff, despite the Supreme Court having recently paused a broader version of that order. The Justice Department has asked the 1st U.S. Circuit Court of Appeals to intervene, arguing that Joun's refusal to lift the narrower injunction contradicts the Supreme Court's ruling and undermines the rule of law.The judge's decision stems from a lawsuit challenging Secretary of Education Linda McMahon's plan to lay off over 1,300 department employees, part of President Trump's broader goal of eliminating the department—something only Congress can authorize. The plaintiffs, including students and advocacy groups, focused specifically on the Office for Civil Rights, which was set to lose half its staff. They argue that lifting the injunction now would effectively reward the administration's ongoing failure to comply with the court's order, as the terminated employees have not yet been reinstated.Judge Joun, appointed by President Biden, criticized the Supreme Court's ruling as "unreasoned" and pointed to the administration's continued noncompliance. The 1st Circuit has asked the plaintiffs to respond promptly to the Justice Department's request, signaling an expedited review.Trump administration claims judge defied Supreme Court to bar Education Department firings | ReutersFederal Reserve Chair Jerome Powell is preparing for what may be his final speech at the annual Jackson Hole conference, facing a complicated economic picture that challenges his data-driven policy approach. In past years, Powell used the conference to pledge aggressive action against inflation and, later, to support the labor market. Now, with inflation still above target and signs of economic slowdown emerging, Powell must decide whether to prioritize price stability or job preservation.The Trump administration and many investors expect interest rate cuts at the Fed's September meeting, but Powell's messaging—how he frames future actions—may matter more than the decision itself. Internally, Fed officials are split: some want to move quickly to protect jobs, while others want to wait for clearer evidence that inflation won't rebound. Powell has previously styled himself after past Fed chairs like Paul Volcker and Alan Greenspan, with Volcker's inflation-fighting resolve and Greenspan's forward-looking leniency both offering competing models.Recent economic data has sent mixed signals. Revised job growth numbers were lower than initially reported, supporting arguments for easing monetary policy, but inflation has edged up again. Trump's tariff policies add further uncertainty, though their economic impact has so far been less severe than feared. With the economy growing slowly and inflation still above the Fed's 2% target, Powell must decide whether to stay the course, cut rates cautiously, or begin a broader shift.Powell has used Jackson Hole to battle inflation and buoy jobs; he's now caught between both | ReutersNovo Nordisk's shares rose by up to 5% after receiving accelerated U.S. approval for its weight-loss drug Wegovy to treat MASH (metabolic dysfunction-associated steatohepatitis), a progressive liver disease that affects about 5% of U.S. adults. This marks the first GLP-1 drug approved for MASH and offers a significant, if temporary, advantage over competitor Eli Lilly, which is still in clinical trials for its own MASH-targeting drug, tirzepatide.The news was a welcome reversal for Novo, which recently lost over $70 billion in market value following a profit warning and leadership change. The company, once Europe's most valuable publicly traded firm due to Wegovy's success, has seen its share price drop sharply over the past year amid intensifying competition in the obesity drug market and the rise of compounded copycat drugs.Although Novo now holds a short-term lead in the liver disease market, analysts expect that exclusivity will be brief once Eli Lilly gains approval. Novo has also submitted applications in Europe and Japan, signaling its intention to secure broader global use for Wegovy beyond weight loss.Shares in Novo Nordisk rise after Wegovy gets US nod for liver disease treatment | ReutersNorton Rose's ambitious tech partnership with NMBL Technologies has ended in failure and mutual lawsuits, highlighting how difficult it is for Big Law firms to pivot from selling legal services to selling tech products. The firm's Chicago office, launched in 2022 as an “innovation hub,” aimed to introduce 150 clients to Proxy, a legal workflow tool developed by a new partner, Daniel Farris. But three years later, not a single sale was made. NMBL claims Norton Rose didn't uphold its end of the deal and stifled the rollout, while the firm says clients weren't interested and is seeking damages for the investment.The fallout underscores broader challenges law firms face as they increasingly invest in artificial intelligence and legal tech amid growing demand and rising budgets. Unlike traditional legal work, selling products requires different infrastructure and skills—such as dedicated sales teams—that most law firms lack. Despite producing marketing materials and training resources, NMBL alleges that very few Norton Rose lawyers engaged with the product and that the firm failed to meaningfully promote it.NMBL is seeking $15 million in damages, accusing the firm of using the deal merely to recruit talent, while Norton Rose wants $250,000, calling the product commercially nonviable. The firm also allegedly created a shell subsidiary, LX, to meet contract terms but never properly funded or activated it. This case illustrates the steep learning curve law firms face in transitioning to tech-based business models and the internal resistance that can derail innovation.Firm's Failed Tech Venture Foretells Big Law's AI Sales Struggle This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.minimumcomp.com/subscribe
Stock Market update for August 18, 2025. This video is for informational purposes only and reflects the views of the host and guest, not Public Holdings or its subsidiaries. Mentions of assets are not recommendations. Investing involves risk, including loss. Past performance does not guarantee future results. For full disclosures, visit Public.com/disclosures.
What happens when life throws you a devastating curveball? For Kody and her family, her husband's end-stage liver disease diagnosis with just one year to live became the catalyst for a complete lifestyle transformation. They sold everything, bought a farm, and began growing their own food—a decision that ultimately led to his liver fully healing eight years later.This conversation takes us deep into the intersection of homesteading and homeschooling, revealing how one family found purpose, health, and a thriving business by reconnecting with traditional skills. Kody shares candidly about their journey from thinking "we don't want to spend all day with our children" to creating an integrated life where education happens naturally through meaningful work. Her story of watching her once-struggling son thrive outside traditional education—eventually becoming a $50/hour foreman at age 20—challenges conventional thinking about learning and success.As founder of Homestead Education, Kody created curriculum that's now used in five countries after discovering a surprising gap in agricultural education resources. "Food is literally humanity's most driving force, and yet nobody knows how to do it," she explains, describing how her materials blend agriculture, science, and home economics for all ages. From raising heritage pigs to managing a micro-dairy, her family demonstrates how developing self-sufficiency skills creates resilience and purpose beyond what conventional systems offer.Whether you're curious about homesteading, considering homeschooling, or simply interested in more sustainable living, this episode offers practical wisdom and inspiration. Visit thehomesteadeducation.com to explore Kody's curriculum and resources for starting your own journey toward greater self-sufficiency and purposeful living.Check out Kody's work at: Homestead EducationWhat is the most important thing we can teach our kids?HOW TO HANDLE AN EMERGENCY!This could mean life or death in some cases!Help a child you know navigate how to handle an emergency situation with ease: Let's Talk, Emergencies! -
In this episode, Dr Gideon Hirschfield meets with patient advocate Jess Schnur to discuss challenges related to the diagnosis and management of primary biliary cholangitis (PBC) to provide actionable strategies for healthcare professionals to incorporate into patient care, including:Disease concerns and frequently asked questions from a patient perspectiveManaging symptomsTreatment options and supportive careImportance of awareness and educationPresenters:Gideon Hirschfield, MA, MB BChir, FRCP, PhDLily and Terry Horner Chair in Autoimmune Liver Disease ResearchProfessor, Division of Gastroenterology and HepatologyUniversity of TorontoDirector, The Autoimmune and Rare Liver Disease ProgrammeDirector, Francis Family Liver ClinicToronto General Hospital, University Health NetworkOntario, CanadaJess N. Schnur, BSN-RNNational PBC Patient AdvocateAmerican Liver FoundationDonation Support Services CoordinatorLifeline of OhioColumbus, OhioTo learn more, see the programHear Me: Patient Perspectives on PBC
Niall McKay talks to Harriet Medeley about her diagnosis of Primary Sclerosing Cholangitis (PSC) and how it inspired her to write Outpatient, an award-winning comedy play which opened in London this month. They discuss how her diagnosis, her life as an artist and mother and turning a life changing disease into art and comedy.
Your liver plays a critical role in your overall health, but signs of trouble can be easy to miss. In this episode, Nurse Doza uncovers the early warning signals of liver dysfunction, from chronic fatigue to weight gain, and explains how your diet, sleep, and stress levels impact liver health. Learn practical steps to support your liver naturally and optimize your well-being. 5 KEY TAKEAWAYS Persistent fatigue is often a sign of liver dysfunction, as the liver regulates energy metabolism. Poor sleep quality, including sleep apnea, is linked to an increased risk of liver disease. Gut health and liver function are closely connected—irregular bowel movements may indicate liver issues. Cognitive decline and brain fog can be early indicators of non-alcoholic fatty liver disease (NAFLD). Weight gain and metabolic imbalances are often tied to liver health and insulin resistance. FEATURED PRODUCT Liver Boost – Packed with essential nutrients to support optimal liver function, Liver Boost promotes detoxification, enhances bile flow, and helps combat oxidative stress. Give your liver the support it needs to function at its best. TIMESTAMPS 00:00 START 03:15 The first sign: Chronic fatigue and liver dysfunction 10:30 How stress and the adrenal glands impact liver health 15:45 The second sign: Poor sleep and its link to liver disease 21:00 The third sign: Gut health and irregular bowel movements 27:10 How your liver processes toxins and the role of bile RESOURCES MENTIONED "How Fatigue and Liver Disease Are Connected" – https://pmc.ncbi.nlm.nih.gov/articles/PMC6676553/ "The Link Between Liver Disease and Sleep Apnea" – https://aapmd.org/sleep-disorders/the-link-between-liver-disease-and-sleep-apnea "Gut Microbiome, IBS, and Liver Disease" – https://pmc.ncbi.nlm.nih.gov/articles/PMC8727221/ "NAFLD and Cognitive Decline" – https://www.neurology.org/doi/10.1212/wnl.0000000000200853 "Weight Gain and Liver Health" – https://pmc.ncbi.nlm.nih.gov/articles/PMC6591731/
TakeawaysMASH is a significant obesity-related complication.Semaglutide shows promise in treating MASH.Weight loss is crucial for improving liver health.Bariatric surgery remains the most effective treatment.The Essence trial indicates a 63% resolution of NASH.New medications are being developed for obesity treatment.Early intervention is key to preventing severe liver damage.Accessibility of medications is a major concern.Comparative studies are essential for evaluating new treatments.Future treatments may include innovative delivery methods.Chapters00:00 Introduction to MASH and Semaglutide Study04:29 Understanding Metabolic Dysfunction and Its Implications08:02 Essence Trial: Semaglutide's Impact on MASH12:58 Comparative Analysis of New Treatments for MASH17:30 The Future of Obesity Treatment and Drug AccessibilityJoin Vineyard - Dr. Spencer's online clinicSee the study