Podcasts about Liver disease

For weight loss, complete avoidance of ultra-processed foods outperforms mere “healthy diet” comprising minimally-processed items; Research fraud undermines anti-dementia drug pipeline; Comprehensive lifestyle modification program scores against cognitive decline; Women's brains especially vulnerable to Omega-3 deficiencies; Bible says “Lame shall walk again” and 21st century science may soon bring about this miracle; Breakthroughs in rheumatoid arthritis treatment.

This Day in Legal History: Nineteenth Amendment RatifiedOn August 18, 1920, the Nineteenth Amendment to the U.S. Constitution was ratified, guaranteeing women the right to vote and marking a major legal milestone in the struggle for gender equality. The amendment states simply: “The right of citizens of the United States to vote shall not be denied or abridged… on account of sex.” Its passage capped off more than 70 years of organized activism, dating back to the Seneca Falls Convention in 1848. Suffragists like Susan B. Anthony, Elizabeth Cady Stanton, Sojourner Truth, and Alice Paul played pivotal roles in maintaining momentum across generations, despite fierce opposition.The road to ratification was grueling. Congress passed the amendment in 1919, but it still required approval from three-fourths of the states—36 at the time. Tennessee became the critical 36th state, narrowly approving the amendment in a dramatic vote where a 24-year-old legislator, Harry T. Burn, changed his vote after receiving a letter from his mother urging him to support suffrage. That moment tipped the scales and enshrined the right to vote for women nationwide.Before the amendment, several western states had already extended suffrage to women, but many others actively suppressed it. The legal recognition of women's voting rights through constitutional amendment removed any ambiguity and forced all states to comply. The Nineteenth Amendment not only transformed the electorate but also reshaped American democracy by recognizing women as full political participants.The Trump administration is accusing a federal judge in Boston of undermining the authority of the U.S. Supreme Court by continuing to block the administration from firing staff in the Department of Education's Office for Civil Rights. U.S. District Judge Myong Joun had issued an injunction requiring the reinstatement of employees let go in a mass layoff, despite the Supreme Court having recently paused a broader version of that order. The Justice Department has asked the 1st U.S. Circuit Court of Appeals to intervene, arguing that Joun's refusal to lift the narrower injunction contradicts the Supreme Court's ruling and undermines the rule of law.The judge's decision stems from a lawsuit challenging Secretary of Education Linda McMahon's plan to lay off over 1,300 department employees, part of President Trump's broader goal of eliminating the department—something only Congress can authorize. The plaintiffs, including students and advocacy groups, focused specifically on the Office for Civil Rights, which was set to lose half its staff. They argue that lifting the injunction now would effectively reward the administration's ongoing failure to comply with the court's order, as the terminated employees have not yet been reinstated.Judge Joun, appointed by President Biden, criticized the Supreme Court's ruling as "unreasoned" and pointed to the administration's continued noncompliance. The 1st Circuit has asked the plaintiffs to respond promptly to the Justice Department's request, signaling an expedited review.Trump administration claims judge defied Supreme Court to bar Education Department firings | ReutersFederal Reserve Chair Jerome Powell is preparing for what may be his final speech at the annual Jackson Hole conference, facing a complicated economic picture that challenges his data-driven policy approach. In past years, Powell used the conference to pledge aggressive action against inflation and, later, to support the labor market. Now, with inflation still above target and signs of economic slowdown emerging, Powell must decide whether to prioritize price stability or job preservation.The Trump administration and many investors expect interest rate cuts at the Fed's September meeting, but Powell's messaging—how he frames future actions—may matter more than the decision itself. Internally, Fed officials are split: some want to move quickly to protect jobs, while others want to wait for clearer evidence that inflation won't rebound. Powell has previously styled himself after past Fed chairs like Paul Volcker and Alan Greenspan, with Volcker's inflation-fighting resolve and Greenspan's forward-looking leniency both offering competing models.Recent economic data has sent mixed signals. Revised job growth numbers were lower than initially reported, supporting arguments for easing monetary policy, but inflation has edged up again. Trump's tariff policies add further uncertainty, though their economic impact has so far been less severe than feared. With the economy growing slowly and inflation still above the Fed's 2% target, Powell must decide whether to stay the course, cut rates cautiously, or begin a broader shift.Powell has used Jackson Hole to battle inflation and buoy jobs; he's now caught between both | ReutersNovo Nordisk's shares rose by up to 5% after receiving accelerated U.S. approval for its weight-loss drug Wegovy to treat MASH (metabolic dysfunction-associated steatohepatitis), a progressive liver disease that affects about 5% of U.S. adults. This marks the first GLP-1 drug approved for MASH and offers a significant, if temporary, advantage over competitor Eli Lilly, which is still in clinical trials for its own MASH-targeting drug, tirzepatide.The news was a welcome reversal for Novo, which recently lost over $70 billion in market value following a profit warning and leadership change. The company, once Europe's most valuable publicly traded firm due to Wegovy's success, has seen its share price drop sharply over the past year amid intensifying competition in the obesity drug market and the rise of compounded copycat drugs.Although Novo now holds a short-term lead in the liver disease market, analysts expect that exclusivity will be brief once Eli Lilly gains approval. Novo has also submitted applications in Europe and Japan, signaling its intention to secure broader global use for Wegovy beyond weight loss.Shares in Novo Nordisk rise after Wegovy gets US nod for liver disease treatment | ReutersNorton Rose's ambitious tech partnership with NMBL Technologies has ended in failure and mutual lawsuits, highlighting how difficult it is for Big Law firms to pivot from selling legal services to selling tech products. The firm's Chicago office, launched in 2022 as an “innovation hub,” aimed to introduce 150 clients to Proxy, a legal workflow tool developed by a new partner, Daniel Farris. But three years later, not a single sale was made. NMBL claims Norton Rose didn't uphold its end of the deal and stifled the rollout, while the firm says clients weren't interested and is seeking damages for the investment.The fallout underscores broader challenges law firms face as they increasingly invest in artificial intelligence and legal tech amid growing demand and rising budgets. Unlike traditional legal work, selling products requires different infrastructure and skills—such as dedicated sales teams—that most law firms lack. Despite producing marketing materials and training resources, NMBL alleges that very few Norton Rose lawyers engaged with the product and that the firm failed to meaningfully promote it.NMBL is seeking $15 million in damages, accusing the firm of using the deal merely to recruit talent, while Norton Rose wants $250,000, calling the product commercially nonviable. The firm also allegedly created a shell subsidiary, LX, to meet contract terms but never properly funded or activated it. This case illustrates the steep learning curve law firms face in transitioning to tech-based business models and the internal resistance that can derail innovation.Firm's Failed Tech Venture Foretells Big Law's AI Sales Struggle This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.minimumcomp.com/subscribe

Stock Market update for August 18, 2025. This video is for informational purposes only and reflects the views of the host and guest, not Public Holdings or its subsidiaries. Mentions of assets are not recommendations. Investing involves risk, including loss. Past performance does not guarantee future results. For full disclosures, visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Public.com/disclosures⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

Dr. Mitch Shulman can be heard every weekday morning at 7:50 on The Andrew Carter Morning Show.

Vicky and Peter are joined by Ed Britain a Consultant Hepatologist around some liver disease cases and learning.This is episode one of two, so watch this space for the second part.

Dr. Jennifer Flemming is an associate professor in medicine and public health at Queen's University Learn more about your ad choices. Visit megaphone.fm/adchoices

0:11 - Summer Festivals. 5:52 - MAGA musician permit revocations spark public space debate. 14:52 - Trump's war on Fed Chair Jerome Powell could roil Canada, and your mortgage. 25:35 - The Social Fray with Dan Jones. 36:00 - Seniors rarely downsize. Here's why it hurts first-time home buyers. 44:14 - Your calls and texts on the MAGA Musician. 55:17 - Your thoughts on freedom of expression. 1:01:41 - If you're drinking a lot, you're at greater risk of liver disease. Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode of VHHA's Patients Come First podcast features Dr. Arun Sanyal, Director of the Stravitz-Sanyal Institute for Liver Disease and Metabolic Health at VCU Health. Dr. Sanyal is a return guest who joins us to share insight about an exciting new clinical study showing that a medicine approved for use in treating diabetes and obesity has benefits for patients with a particular type of liver disease. Send questions, comments, feedback, or guest suggestions to pcfpodcast@vhha.com or contact on X (Twitter) or Instagram using the #PatientsComeFirst hashtag.

This episode of VHHA's Patients Come First podcast features Dr. Saul Karpen, Chief Scientific Officer of the Virginia Commonwealth University Stravitz-Sanyal Institute for Liver Disease and Metabolic Health and President-Elect of the American Association for the Study of Liver Disease. He joins us for a conversation about his work, new pediatric guidelines developed to detect a life-threatening liver disease in infants, and more. Send questions, comments, feedback, or guest suggestions to pcfpodcast@vhha.com or contact on X (Twitter) or Instagram using the #PatientsComeFirst hashtag.

What happens when life throws you a devastating curveball? For Kody and her family, her husband's end-stage liver disease diagnosis with just one year to live became the catalyst for a complete lifestyle transformation. They sold everything, bought a farm, and began growing their own food—a decision that ultimately led to his liver fully healing eight years later.This conversation takes us deep into the intersection of homesteading and homeschooling, revealing how one family found purpose, health, and a thriving business by reconnecting with traditional skills. Kody shares candidly about their journey from thinking "we don't want to spend all day with our children" to creating an integrated life where education happens naturally through meaningful work. Her story of watching her once-struggling son thrive outside traditional education—eventually becoming a $50/hour foreman at age 20—challenges conventional thinking about learning and success.As founder of Homestead Education, Kody created curriculum that's now used in five countries after discovering a surprising gap in agricultural education resources. "Food is literally humanity's most driving force, and yet nobody knows how to do it," she explains, describing how her materials blend agriculture, science, and home economics for all ages. From raising heritage pigs to managing a micro-dairy, her family demonstrates how developing self-sufficiency skills creates resilience and purpose beyond what conventional systems offer.Whether you're curious about homesteading, considering homeschooling, or simply interested in more sustainable living, this episode offers practical wisdom and inspiration. Visit thehomesteadeducation.com to explore Kody's curriculum and resources for starting your own journey toward greater self-sufficiency and purposeful living.Check out Kody's work at: Homestead EducationWhat is the most important thing we can teach our kids?HOW TO HANDLE AN EMERGENCY!This could mean life or death in some cases!Help a child you know navigate how to handle an emergency situation with ease: Let's Talk, Emergencies! -

In this episode, Dr Gideon Hirschfield meets with patient advocate Jess Schnur to discuss challenges related to the diagnosis and management of primary biliary cholangitis (PBC) to provide actionable strategies for healthcare professionals to incorporate into patient care, including:Disease concerns and frequently asked questions from a patient perspectiveManaging symptomsTreatment options and supportive careImportance of awareness and educationPresenters:Gideon Hirschfield, MA, MB BChir, FRCP, PhDLily and Terry Horner Chair in Autoimmune Liver Disease ResearchProfessor, Division of Gastroenterology and HepatologyUniversity of TorontoDirector, The Autoimmune and Rare Liver Disease ProgrammeDirector, Francis Family Liver ClinicToronto General Hospital, University Health NetworkOntario, CanadaJess N. Schnur, BSN-RNNational PBC Patient AdvocateAmerican Liver FoundationDonation Support Services CoordinatorLifeline of OhioColumbus, OhioTo learn more, see the programHear Me: Patient Perspectives on PBC

Host: Peter Buch, MD, FACG, AGAF, FACP Guest: Ashwani K. Singal MD, MS, FACG, FAASLD, AGAF Sarcopenia and poor nutrition are often silent threats in chronic liver disease, yet they drastically impact outcomes. Joining Dr. Peter Buch to discuss strategies for recognizing and addressing malnutrition early to improve long-term liver health is Dr. Ashwani Singal. Dr. Singal is a Professor of Medicine at the University of Louisville School of Medicine.

Host: Peter Buch, MD, FACG, AGAF, FACP Guest: Ashwani K. Singal MD, MS, FACG, FAASLD, AGAF Sarcopenia and poor nutrition are often silent threats in chronic liver disease, yet they drastically impact outcomes. Joining Dr. Peter Buch to discuss strategies for recognizing and addressing malnutrition early to improve long-term liver health is Dr. Ashwani Singal. Dr. Singal is a Professor of Medicine at the University of Louisville School of Medicine.

This episode addresses key challenges in vascular complications of liver disease, including the management of portal vein thrombosis (PVT) in patients with and without cirrhosis. Experts will explore controversies surrounding long-term anticoagulation therapy and discuss insights from the CIRROXABAN paper. Additionally, the episode will shed light on the management of splanchnic artery aneurysms, offering valuable guidance for clinical practice.Moderator:  Pierre-Emmanuel Rautou;Faculty: Sarwa Darwish Murad, Juan-Carlos Garcia-Pagan, Valérie Vilgrain Related episodesS4E11 – YI Choice: Gene therapy for liver disease — RNA interference and beyondS4E6 – Regenerating the liver graft with a machine?S3E11 – Regenerative Hepatology: From stem cells to tissue engineeringS2E9 – YI Choice: Propelling liver cell biology into the third dimensionAll EASL Studio Podcasts are available on EASL Campus.Click here to see all EASL Video Podcasts on Apple Podcasts.

This EASL Studio episode explores state-of-the-art practices in diagnosing steatotic liver disease and stratifying patients effectively for targeted treatment in 2025. Focusing on integrating cardiometabolic risk profiling and dynamic alcohol consumption assessment, the discussion will discuss contemporary methods, frequency, and practical implementation in clinical settings to enhance precision medicine approaches.Moderator: Aleksander Krag Faculty: Meena Bansal, Mattias Ekstedt, Arun Sanyal All EASL Studio Podcasts are available on EASL Campus.Click here to see all EASL Video Podcasts on Apple Podcasts.

Host: Jasmine T. Kency, M.D., Associate Professor of Internal Medicine and Pediatrics at the University of Mississippi Medical Center.Topic: Liver DiseaseEmail the show any time women@mpbonline.org. Hosted on Acast. See acast.com/privacy for more information.

Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we look at three new pieces of research with implications for general practice.Firstly, can exercise prevent the recurrence of colorectal cancer? Short answer, yes. But how much exercise did you need to do, and what on earth is a MET? Secondly, what are the concerns around low-dose amitriptyline use for IBS from patients and GPs? How can we aid the discussion? Finally, can SLGT2 inhibitors improve liver disease? Is this the new treatment for our patients with MASLD (the condition formerly known as NAFLD? ReferencesNEJM Exercise and CRCMETs WikipediaBJGP IBS & amitriptyline prescribingBMJ SGLT2i & MASLDNB Blog MASLD: The rebrand you never heard ofwww.nbmedical.com/podcast

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Prevalence, Risk Factors, and Prognosis for Fontan-Associated Liver Disease: A Systematic Review and Exploratory Meta-Analysis.

Niall McKay talks to Harriet Medeley about her diagnosis of Primary Sclerosing Cholangitis (PSC) and how it inspired her to write Outpatient, an award-winning comedy play which opened in London this month. They discuss how her diagnosis, her life as an artist and mother and turning a life changing disease into art and comedy.

Your liver plays a critical role in your overall health, but signs of trouble can be easy to miss. In this episode, Nurse Doza uncovers the early warning signals of liver dysfunction, from chronic fatigue to weight gain, and explains how your diet, sleep, and stress levels impact liver health. Learn practical steps to support your liver naturally and optimize your well-being. 5 KEY TAKEAWAYS Persistent fatigue is often a sign of liver dysfunction, as the liver regulates energy metabolism. Poor sleep quality, including sleep apnea, is linked to an increased risk of liver disease. Gut health and liver function are closely connected—irregular bowel movements may indicate liver issues. Cognitive decline and brain fog can be early indicators of non-alcoholic fatty liver disease (NAFLD). Weight gain and metabolic imbalances are often tied to liver health and insulin resistance. FEATURED PRODUCT Liver Boost – Packed with essential nutrients to support optimal liver function, Liver Boost promotes detoxification, enhances bile flow, and helps combat oxidative stress. Give your liver the support it needs to function at its best. TIMESTAMPS 00:00 START 03:15 The first sign: Chronic fatigue and liver dysfunction 10:30 How stress and the adrenal glands impact liver health 15:45 The second sign: Poor sleep and its link to liver disease 21:00 The third sign: Gut health and irregular bowel movements 27:10 How your liver processes toxins and the role of bile RESOURCES MENTIONED "How Fatigue and Liver Disease Are Connected" – https://pmc.ncbi.nlm.nih.gov/articles/PMC6676553/ "The Link Between Liver Disease and Sleep Apnea" – https://aapmd.org/sleep-disorders/the-link-between-liver-disease-and-sleep-apnea "Gut Microbiome, IBS, and Liver Disease" – https://pmc.ncbi.nlm.nih.gov/articles/PMC8727221/ "NAFLD and Cognitive Decline" – https://www.neurology.org/doi/10.1212/wnl.0000000000200853 "Weight Gain and Liver Health" – https://pmc.ncbi.nlm.nih.gov/articles/PMC6591731/

TakeawaysMASH is a significant obesity-related complication.Semaglutide shows promise in treating MASH.Weight loss is crucial for improving liver health.Bariatric surgery remains the most effective treatment.The Essence trial indicates a 63% resolution of NASH.New medications are being developed for obesity treatment.Early intervention is key to preventing severe liver damage.Accessibility of medications is a major concern.Comparative studies are essential for evaluating new treatments.Future treatments may include innovative delivery methods.Chapters00:00 Introduction to MASH and Semaglutide Study04:29 Understanding Metabolic Dysfunction and Its Implications08:02 Essence Trial: Semaglutide's Impact on MASH12:58 Comparative Analysis of New Treatments for MASH17:30 The Future of Obesity Treatment and Drug AccessibilityJoin Vineyard - Dr. Spencer's online clinicSee the study

Introducing Liver Lineup: Updates & Unfiltered Insights — an exciting new podcast delivering timely, candid perspectives on the most pressing topics in the fast-moving world of hepatology. Created by Nancy Reau, MD, and Kimberly Brown, MD, and hosted by HCPLive, this series dives into the cutting edge of liver disease research, clinical care, and real-world practice. Intended for hepatologists, gastroenterologists, and other clinicians managing liver disease, Liver Lineup will unpack the latest research, debate emerging controversies, and spotlight developments that could shape — or sharpen — day-to-day practice, all with unfiltered perspective and clarity. Brown is division chief of gastroenterology and hepatology and the Associate Medical Director of the Henry Ford Hospital Transplant Institute at Henry Ford Hospital. She is also a Professor of Medicine at Wayne State University Reau is a professor of internal medicine, the Richard B. Capps Chair of Hepatology, Associate Director of Solid Organ Transplantation, and the section chief of Hepatology at Rush University Medical Center. In the inaugural episode, Brown and Reau introduce the mission behind Liver Lineup and share why they created the podcast. Driven by a shared commitment to education, clinical excellence, and elevating the conversation around liver disease, the hosts describe their hope to offer practicing clinicians a clear, concise, and engaging way to keep up with the latest news and innovations in hepatology. They aim to highlight data that's not only new, but meaningful — spotlighting developments that can improve patient care today and shape best practices tomorrow. Together, the Brown and Reau set the stage for what's to come: expert commentary on major liver meetings including Digestive Disease Week, European Association for the Study of the Liver Congress, The Liver Meeting from the American Association for the Study of Liver Diseases, and the American College of Gastroenterology Annual Meeting; coverage of key topics like MASLD, liver cancer, viral hepatitis, and transplant; and conversations with colleagues across the hepatology spectrum. From debates over practice-changing data to discussions on care pathways and diagnostics, Liver Lineup aims to keep clinicians informed, engaged, and ready to translate insight into impact. Looking ahead, Brown and Reau preview upcoming episodes covering major hepatology updates from Digestive Disease Week 2025 and European Association for the Study of the Liver Congress 2025 — with more to follow throughout the year.

Send us a textWhat happens when “just one glass” turns into a deadly diagnosis?In this raw and riveting episode of Feel Lit Alcohol Free, Ruby Williams and Susan Larkin sit down with Karla Adkins, co-founder of Zero Proof Life and author of She Came Tumbling Down. Karla was a young professional when she was diagnosed with cirrhosis of the liver at just 36—a wake-up call that nearly came too late!Why Karla wrote her riveting book: "I can't be silent anymore. I have to share my story. I want people to know what can happen, the truth of this dangerous game that a lot of people are playing."We dive deep into:✅ The toxic culture of pandemic drinking and “mommy wine” humor✅ Why liver disease is rising rapidly in women ages 25–34✅ What it really takes to heal—physically, emotionally, and spiritually✅ How Karla went from silent shame to powerful sobriety advocateThis conversation is urgent, inspiring, and unforgettable. Let's get into it.Read Karla's compelling story And She Came Tumbling Down : Breaking the Bonds of Alcohol and Creating a Life of Freedom Connect with Karla: Karlaadkins.com  @thezeroprooflife @karlakadkinsListeners have said that our podcast has helped them get alcohol free! So we created Feel Lit 21, a way for you to press your reset button and take a 21 day break from alcohol. Every day you will receive emails with videos, journal prompts, and the inspiration you need to embrace 21 days without alcohol that feels lit! Leave a review on Apple Podcasts, and ask us any questions you have about breaking free from wine or living an alcohol-free lifestyle. Websites:Susan Larkin Coaching https://www.susanlarkincoaching.com/ Ruby Williams at Freedom Renegade Coaching https://www.freedomrenegadecoaching.com/Follow Susan: @drinklesswithsusanFollow Ruby: @rubywilliamscoachingIt is strongly recommended that you seek professional advice regarding your health before attempting to take a break from alcohol. The creators, hosts, and producers of the The Feel Lit Alcohol Free podcast are not healthcare practitioners and therefore do not give medical, or psychological advice nor do they intend for the podcast, any resource or communication on behalf of the podcast or otherwise to be a substitute for such.

This episode of VHHA's Patients Come First podcast features Dr. Juan Pablo Arab, a transplant hepatologist and director of alcohol science with the Stravitz-Sanyal Institute for Liver Disease at VCU Health. This conversation covers liver health, insights gleaned from recent research into U.S. liver disease prevalence, the impact of early screening and targeted intervention, and more. Send questions, comments, feedback, or guest suggestions to pcfpodcast@vhha.com or contact on X (Twitter) or Instagram using the #PatientsComeFirst hashtag.

For National Donate Life Month, Health Matters revisits the conversation between our host, Angelique Serrano, and NewYork-Presbyterian and Columbia transplant hepatologist Dr. Alyson Fox. They talk about the differences between living donation and deceased donation, walk through the steps of preparation and recovery for organ donation and transplant, and the importance of this lifesaving gift.___Alyson Fox, MD, is medical director of the adult transplant program at NewYork-Presbyterian and Columbia. Dr. Fox's clinical practice is focused on the management of patients with a variety of liver diseases including viral hepatitis, alcoholic and non-alcoholic fatty liver diseases, inherited and autoimmune liver diseases and liver cancers. As a transplant hepatologist, she has advanced training in the management of the complications of end stage liver disease and caring for patients both pre- and post-liver transplantation. When she is not caring for patients, she is active as a course director and educator at the Columbia University Vagelos College of Physicians and Surgeons.___Health Matters is your weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine. To learn more visit: https://healthmatters.nyp.org

A study published in JAMA Internal Medicine found that statin use in patients with chronic liver disease was associated with a lower risk of liver cancer and hepatic decompensation, suggesting potential protective effects beyond lipid management. Surveys by the Annenberg Public Policy Center revealed widespread misinformation about the risks of consuming raw milk, highlighting the need for public education on the importance of pasteurization. New research links red meat allergy (alpha-gal syndrome) to bites from deer ticks and western black-legged ticks, expanding the geographic risk area and emphasizing the need for clinicians to consider this diagnosis in patients with unexplained allergic symptoms following tick bites.

In this episode, Dr Gideon Hirschfield meets with patient advocate Jess Schnur to discuss challenges related to the diagnosis and management of primary biliary cholangitis (PBC) to provide actionable strategies for healthcare professionals to incorporate into patient care, including:Disease concerns and frequently asked questions from a patient perspectiveManaging symptomsTreatment options and supportive careImportance of awareness and educationPresenters:Gideon Hirschfield, MA, MB BChir, FRCP, PhDLily and Terry Horner Chair in Autoimmune Liver Disease ResearchProfessor, Division of Gastroenterology and HepatologyUniversity of TorontoDirector, The Autoimmune and Rare Liver Disease ProgrammeDirector, Francis Family Liver ClinicToronto General Hospital, University Health NetworkOntario, CanadaJess N. Schnur, BSN-RNNational PBC Patient AdvocateAmerican Liver FoundationDonation Support Services CoordinatorLifeline of OhioColumbus, OhioTo learn more, see the program Hear Me: Patient Perspectives on PBC

Mándanos un mensaje¿Alguna vez has sentido que sigues todas las reglas pero tu cuerpo no responde como esperabas? La respuesta podría estar en tus biomarcadores, esas pequeñas señales químicas que revelan la verdad sobre tu salud mucho antes que cualquier síntoma visible.Organizaciones de saludAmerican Diabetes Association (ADA): https://diabetes.org/American Heart Association (AHA): https://www.heart.org/World Health Organization (WHO): https://www.who.int/National Institutes of Health (NIH): https://www.nih.gov/Centers for Disease Control and Prevention (CDC): https://www.cdc.gov/Endocrine Society: https://www.endocrine.org/American College of Rheumatology: https://www.rheumatology.org/American Association for the Study of Liver Diseases: https://www.aasld.org/Estudios científicos específicosHemoglobina A1C: American Diabetes Association. (2021). Glycemic Targets: Standards of Medical Care in Diabetes. Diabetes Care, 44(Supplement 1): S73-S84.Ferritina y rendimiento: Sim, M., et al. (2019). Iron considerations for the athlete: a narrative review. European Journal of Applied Physiology, 119(7): 1463-1478.Miocinas: Pedersen, B. K. (2019). Physical activity and muscle-brain crosstalk. Nature Reviews Endocrinology, 15(7): 383-392.Perfil lipídico y riesgo cardiovascular: Grundy, S. M., et al. (2019). 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Journal of the American College of Cardiology, 73(24): e285-e350.Vitamina D: Holick, M. F., et al. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 96(7): 1911-1930.Enzimas hepáticas: Kwo, P. Y., et al. (2017). ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. The American Journal of Gastroenterology, 112(1): 18-35.Ácido úrico y enfermedad cardiovascular: Borghi, C., et al. (2020). Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk. Cardiology, 145(1): 1-10.Variabilidad de frecuencia cardíaca: Shaffer, F., & Ginsberg, J. P. (2017). An Overview of Heart Rate Variability Metrics and Norms. Frontiers in Public Health, 5: 258.Support the showInstagram: andieillanesPágina web: andieillanes.com.mx

Supported by Gilead Sciences Europe Ltd who provided funding for this content and is intended for healthcare professionals. Gilead Sciences Europe Ltd was not involved in the creation of this content. The views and opinions expressed in this podcast are those of the individual speakers and do not necessarily reflect those of Gilead Sciences Europe Ltd or EMJ. Note that not all treatments discussed in this episode may have received market approval. Please refer to your local marketing authorisation and prescribing practices for guidance. The speakers received honoraria. Tune into this episode hosted by Hannah Moir, which discusses what PBC is, and key takeaways from the AASLD conference.

Dr. Centor discusses metabolic dysfunction-associated steatotic liver disease with Dr. Michelle Lai.

What can serum bile acid (BA) levels tell us about cholestatic liver diseases? Credit available for this activity expires: 3/13/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002302?ecd=bdc_podcast_libsyn_mscpedu

Podcast 277 – The Unfiltered Truth About Liver Disease – Beth Lehman – Liver Life Walk at Brook Run Park   Beth Lehman's battle with alcoholism and liver cancer nearly cost her life, but a transplant saved her. Now she's on a mission to raise awareness with the Liver Life Walk Atlanta on April 12th at Brook Run Park. This walk, not a run, ensuring everyone can participate. Beth shares the urgent need for organ donors, and explains how most other countries automatically enroll donors. In the US, it is an opt-in program, and the number of donors is falling. Dunwoody, let's show up and make a difference! liverlifewalk.org/atlanta

This recording features audio versions of March 2025 Journal of Vascular and Interventional Radiology (JVIR) abstracts:Safety and Effectiveness of Early Primary Stent Placement for Hepatic Artery Stenosis in Liver Transplant Recipients ReadThe LAVA Study: A Prospective, Multicenter, Single-Arm Study of a Liquid Embolic System for Treatment of Peripheral Arterial Hemorrhage ReadVenous Stents Placed for Postthrombotic Syndrome: The Role of Inflow Disease on Patency ReadProstatic Artery Embolization: Mid- to Long-Term Outcomes in 1,075 Patients ReadArtificial Intelligence-Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases ReadA Decade Long Analysis of Healthcare Disparities and Uterine Artery Embolization: An Exploration of Social Determinants of Health ReadAlso make sure to check out the issue's special content dedicated to the SIR 50th Anniversary.JVIR and SIR thank all those who helped record this episode. To sign up to help with future episodes, please contact our outreach coordinator at millennie.chen.jvir@gmail.com.  Host:Sonya Choe, University of California Riverside School of MedicineAudio editor:Hannah Curtis, Loma Linda University School of MedicineOutreach coordinator:Millennie Chen, University of California Riverside School of MedicineAbstract readers:Brian Tangsombatvisit, University of California San Francisco School of MedicineMatthew Kim, University of California San Francisco School of MedicineCrystal Chin, Touro College of Osteopathic MedicineDave Enriquez, University of California Riverside School of MedicineDaniel Roh, Loma Linda University School of MedicineLauren Lee, Washington State University Elson S. Floyd College of MedicineSIR thanks BD for its generous support of the Kinked Wire.Contact us with your ideas and questions, or read more about about interventional radiology in IR Quarterly magazine or SIR's Patient Center.(c) Society of Interventional Radiology.Support the show

Drs Carol H. Wysham and Scott Isaacs discuss incorporating the screening and management of metabolic dysfunction–associated steatotic liver disease in endocrine practice. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002045. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Type 2 Diabetes Mellitus https://emedicine.medscape.com/article/117853-overview Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review https://pubmed.ncbi.nlm.nih.gov/37700494/ Fibrosis-4 (FIB-4) Calculator https://www.hepatitisc.uw.edu/page/clinical-calculators/fib-4 Liver Fibrosis Assessment: MR and US Elastography https://pubmed.ncbi.nlm.nih.gov/34687329/ Using the FIB-4, Automatically Calculated, Followed by the ELF Test in Second Line to Screen Primary Care Patients for Liver Disease https://pubmed.ncbi.nlm.nih.gov/38806580/ American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD) https://pubmed.ncbi.nlm.nih.gov/35569886/ Mediterranean Diet and Nonalcoholic Fatty Liver Disease https://pubmed.ncbi.nlm.nih.gov/29785077/ Drug Treatment for Metabolic Dysfunction-Associated Steatotic Liver Disease: Progress and Direction https://pubmed.ncbi.nlm.nih.gov/39470028/ Current Status of Glucagon-Like Peptide-1 Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Clinical Perspective https://pubmed.ncbi.nlm.nih.gov/39801787/ Sodium-Glucose Transport Protein 2 (SGLT2) Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK576405/ Update on the Applications and Limitations of Alpha-Fetoprotein for Hepatocellular Carcinoma https://pubmed.ncbi.nlm.nih.gov/35110946/

The Piedmont Transplant Institute in Atlanta performs about 135 liver transplants each year. It's the highest-volume liver transplant center of any nonacademic, community hospital in the United States and is among the top 10% in the nation of all transplant centers.Piedmont's success was achieved primarily because of the collaboration between various interdisciplinary departments—especially IR and hepatology—and an extensive network of referrals.In the audio version of "Transplant teamwork: A community hospital builds successful liver transplant program" (Fall 2019 IR Quarterly), author Melanie Padgett Powers describes a successful Atlanta-based liver transplant program based on a strong collaboration between interventional radiology, hepatology and others.Related resources:Read the original articlePiedmont Transplant Institute websiteSIR thanks BD for its generous support of the Kinked Wire.Contact us with your ideas and questions, or read more about about interventional radiology in IR Quarterly magazine or SIR's Patient Center.(c) Society of Interventional Radiology.Support the show

Dr. Pol Boudes, CMO of Rectify Pharmaceutical, highlights the importance of membrane proteins, specifically the role transporters play in how cells interact with their environment. Rectify is working on developing positive functional modulators (PFM) to address diseases related to dysfunctional transporters the first being primary sclerosing cholangitis, a rare liver disease with no current treatment options. The PFM can potentially restore the normal function of transporters involved in bile composition and secretion, which are key mechanisms in PSC.   Pol explains, "So you have different types of membrane proteins, but what we're working with are called transporters, so they're proteins that are based on the membrane but channel components out and in the cells. So basically, it's a way for the cell to interact with its environment, and you have multiple types of transporter proteins. We're specifically working or started to work with one group of family of proteins that are called the ABC transporters. They're a very important function, and they can either be disrupted because there is a mutation in the protein, so it's a genetic disease, or they are potentially disrupted because there is just a functional deficit of this transporter. The protein is normal, but it's not functioning properly. So it's a functional deficit of what we call the wildtype protein." "So with the PFMs, what we're doing is to use small molecules that you can administer orally, and they bind to the transporter, and by doing so, they can modify the three-dimensional structure of the transporter and consequently the way this protein behaves within the cellular environment. So we correct the function of the transporter by changing the size, if you want, of the shape of the transporter. So we started to focus on this type of proteins and you have many potential diseases due to transporter deficit."  "We're focusing on one disease, liver disease. That's our lead PFM for a disease called primary sclerosing cholangitis, which is a disease of the liver. This very severe liver disease is also a disease that has no treatment available, which is a little bit frustrating because the progression of this disease leads to liver cirrhosis. And the only thing you can do at this stage is liver transplantation. As you might know, liver transplantation is problematic because it's a very complex process, it's also very expensive, and unfortunately, there is a shortage of transplants. So we're trying to address this problem." #RectifyPharma #PrimarySclerosingCholangitis #PSC #RareDisease #LiverDiseases #BileProduction #Transporters rectifypharma.com Listen to the podcast here

Dr. Pol Boudes, CMO of Rectify Pharmaceutical, highlights the importance of membrane proteins, specifically the role transporters play in how cells interact with their environment. Rectify is working on developing positive functional modulators (PFM) to address diseases related to dysfunctional transporters the first being primary sclerosing cholangitis, a rare liver disease with no current treatment options. The PFM can potentially restore the normal function of transporters involved in bile composition and secretion, which are key mechanisms in PSC.   Pol explains, "So you have different types of membrane proteins, but what we're working with are called transporters, so they're proteins that are based on the membrane but channel components out and in the cells. So basically, it's a way for the cell to interact with its environment, and you have multiple types of transporter proteins. We're specifically working or started to work with one group of family of proteins that are called the ABC transporters. They're a very important function, and they can either be disrupted because there is a mutation in the protein, so it's a genetic disease, or they are potentially disrupted because there is just a functional deficit of this transporter. The protein is normal, but it's not functioning properly. So it's a functional deficit of what we call the wildtype protein." "So with the PFMs, what we're doing is to use small molecules that you can administer orally, and they bind to the transporter, and by doing so, they can modify the three-dimensional structure of the transporter and consequently the way this protein behaves within the cellular environment. So we correct the function of the transporter by changing the size, if you want, of the shape of the transporter. So we started to focus on this type of proteins and you have many potential diseases due to transporter deficit."  "We're focusing on one disease, liver disease. That's our lead PFM for a disease called primary sclerosing cholangitis, which is a disease of the liver. This very severe liver disease is also a disease that has no treatment available, which is a little bit frustrating because the progression of this disease leads to liver cirrhosis. And the only thing you can do at this stage is liver transplantation. As you might know, liver transplantation is problematic because it's a very complex process, it's also very expensive, and unfortunately, there is a shortage of transplants. So we're trying to address this problem." #RectifyPharma #PrimarySclerosingCholangitis #PSC #RareDisease #LiverDiseases #BileProduction #Transporters rectifypharma.com Download the transcript here

Earlier this year iECURE reported that an infant with the rare and deadly liver disease OTC deficiency had a complete response to its experimental gene editing therapy. It is believed to be the time that an infant was treated with an in vivo, liver-directed gene editor. The treatment restored ammonia levels in the child's blood to normal and the child is off of ammonia scavenger medicines and is eating a normal diet. We spoke to Joe Truitt, CEO of iECURE, about the company's experimental therapy for OTC, how it works, and its approach to in vivo gene editors.

In this episode, host Courtney Allison discusses the latest studies on the health risks associated with alcohol use with Dr. Robert Brown, chief of Gastroenterology and Hepatology at NewYork-Presbyterian and Weill Cornell Medicine. They discuss how alcohol affects various organs, including your liver, heart, and brain, as well as its link to several cancers. Dr. Brown discusses the cultural perception of alcohol, the current guidelines around safe drinking limits, and how binge drinking harms the body. 

Episode 31  In this episode, we will be discussing hepatic failure.  Topics include:Functions of the liver as a basis for understanding the diseaseFindings in cirrhotic liver diseaseDiagnostic findings in cirrhotic liver diseaseTreatment of liver diseaseHead over to my website to subscribe to my email group!  I send out sample CCRN & PCCN Questions and will be starting a newsletter in 2025!  Click here to join:  https://kayhoppepresents.com/To get my full CCRN Review Online Course, click here:   https://kay-hoppe-presents.teachable.com/p/ccrn-reviewTo get my full PCCN Review Online Course, CLICK HERE:  https://kay-hoppe-presents.teachable.com/p/pccn-review

Joey Mattingly is an associate professor in the Department of Pharmacotherapy at the University of Utah College of Pharmacy. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S.S. Tu, S. Kottilil, and T.J. Mattingly II. Leveraging Old Hepatitis C Therapies. N Engl J Med 2025;392:1-4.

Text and Be HeardIs alcohol truly the festive elixir we often believe it to be, or does it mask a darker reality during the Christmas season? This episode dives into the multifaceted role of alcohol during the holidays, examining how it can be both a source of joy and a potential peril. We explore the cultural tendencies that lead many to overindulge, risking their health and well-being in the process. From the sobering statistics linking alcohol to chronic diseases and accidents to its use as a crutch for loneliness and depression, we shine a light on the serious consequences that often accompany holiday cheer.28 Million Alcoholics in USA,  11% of people 12+400 Million Alcoholics in the World   15+Europe has 15% of their people labeled as AlcoholicsAlcohol increases Chronic Diseases, Mental Health, Liver Disease, Accidents, Injuries and Violence, both Domestic Violence and Homicides.As we navigate this complex relationship, we share insights from the Recovery Freedom Circle, a beacon for those seeking to reclaim their lives from addiction. With over 27 years of Recovery, we discuss the profound benefits of a life without alcohol, including increased energy and enhanced self-worth. We challenge listeners to reconsider the way they celebrate, advocating for a focus on health, family, and the true spirit of Christmas. By prioritizing well-being and embracing a lifestyle of sobriety, you can enrich your life and strengthen your connections with loved ones, turning the festive season into a celebration of genuine joy and spirituality.Support the showRecovery is Beautiful. Go Live Your Best Life!!Facebook Group - Recovery Freedom Circle | FacebookYour EQ is Your IQYouTube - Life Is Wonderful Hugo VRecovery Freedom CircleThe System That Understands Recovery, Builds Character and Helps People Have Better Relationships.A Life Changing Solution, Saves You Time, 18 weekswww.lifeiswonderful.love Instagram - Lifeiswonderful.LoveTikTok - Lifeiswonderful.LovePinterest - Lifeiswonderful.LoveTwitter - LifeWonderLoveLinkedIn - Hugo Vrsalovic Life Is Wonderful.Love

Losing a baby in the early stages of pregnancy can be an extremely painful experience. Having to explain to your employer why you can't come to work only adds to the difficulty. In the UK, there's currently no entitlement to time off for miscarriage within the first six months of pregnancy. The Women and Equalities Select Committee is hearing evidence on extending the right to bereavement leave to cover losses up to 24 weeks. Sarah Owen MP, Chair of the Committee and someone who has experienced baby loss, joined Nuala McGovern to discuss. When the Stammer Came to Stay is award-winning author Maggie O'Farrell's third children's book. Based on her experience of living with a stammer, it celebrates differences and explores children's resilience in facing new challenges. She talks to Anita Rani about the book and how her stammer has shaped her life. Why are more young women dying from alcohol-related liver disease than ever before? BBC journalist Hazel Martin, diagnosed with the condition in her early 30s, has been investigating how her social drinking habits put her life at risk. Hazel joined Nuala along with Professor Debbie Shawcross, Consultant Hepatologist at King's College Hospital, to explore the growing crisis and its causes. After writing her Spinal Column for The Times since 2010 —beginning just two weeks after breaking her neck and back in a riding accident—Melanie Reid has decided it's time to stop. She joined Nuala to discuss why she's stepping away, her reflections on the journey, and her plans for the future. Song-writing partnership Abigail Barlow and Emily Bear are making history by becoming the youngest and first female songwriting duo to compose for a Disney feature film in Moana 2. The Grammy Award-winning pair joined Nula to discuss their musical partnership. Kim Cypher, a saxophonist, composer, and vocalist, is a regular on the London and UK jazz circuit. She recently launched her third album, Catching Moments, and joined Anita in the Woman's Hour studio and performed live.Presenter: Anita Rani Producer: Dianne McGregor

Gain expert insights into best practices in diagnosing progressive familial intrahepatic cholestasis (PFIC), Alagille syndrome, and biliary atresia. Credit available for this activity expires: 11/25/25 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1001956?ecd=bdc_podcast_libsyn_mscpedu

Patients are amazed at the things Dr. Prather picks up on during an initial examination.  But he says this is possible when you know how to interpret the language of your body's symptoms in a holistic way.  In this episode, we talk about:—Why men (and doctors) are "the worst" when it comes to ignoring symptoms that need to be checked out.—The levator scapulae test Dr. Prather uses to identify stress in a patient.  And how patients with severe Depression and Anxiety will often not have relief until the levator scapulae is released. —How a Cardiac Ear Crease on the ear lobe is an indicator of cardiovascular disease.  And how a blemish on the ear can indicate a problem in a specific area of the body.—The link between thickened toe nails and cardiovascular disease.  And how swelling in the ankles (edema) can indicate Kidney Disease or Heart Disease based on upon whether it's in both ankles or just one ankle.—How the loss of hair on a man's legs is an indication of cardiovascular disease.  And how the loss of eyebrows, usually in women, can be an indication of gallbladder disease.—What bags under the eyes and dark circles around the eyes indicate about Kidney Disease and Liver Disease.  And how Plantar Fasciitis can even be a sign of Kidney Disease.—Why Dr. Prather says the Emergency Room should be called for a Gallbladder emergency surgery when a patient says their stool has a white color.  And what a healthy bowel movement should look like.—What urine color, frequency, and the force of your urination reveal about the health of your Kidneys.—How Dr. Prather has "never" had a Headache case where he wasn't able to find the underlying cause.  And how the different types of Headache symptoms help point to the source of the problem.—Why pain should never be ignored because there is always a reason for the pain.  And why Structure-Function Care should be the primary care for a patient.http://www.TheVoiceOfHealthRadio.com

In the last five years, doctors have seen a growing number of patients who need liver transplants because of alcohol use, and sometimes people aren't even aware they're drinking too much. Then, how an indie movie could help Colorado's film industry rebound. Also, stories from a Colorado centenarian about the obstacles he's overcome in his life -- and the rules he lives by. And Colorado Wonders about election security. 

Get ready for another informative episode that raises awareness and empowers people to share their stories about Hepatitis C, featuring Sarah Laurel and Dr. Daniel Moore. Hello, this is Vincent A. Lanci and welcome back to the number 1 podcast show for mental health advocates and champions, "A Mental Health Break." YOU ARE NOT ALONE.Our Guests will discuss more about:-How their health experiences can help make a difference and build a community.-Raising awareness about Hepatitis C, how it is transmitted, and the fact that this disease affects over 4 million people in the US. -How can Hepatitis C be treatedDaniel Moore, MD, MBA, FACEP, physician and co-owner of Thoroughbred Emergency Physicians. He is recognized as a national leader in the field of emergency medicine in quality, safety, and communicable diseases. Sarah Laurel: After overcoming substance use disorder, Sarah was inspired to create resources for women facing similar challenges. What started as a grassroots effort has since evolved into a program offering housing, street outreach, and nationwide training. Drawing from her own experiences, Sarah remains deeply connected to those still on their recovery journey, using her story to inspire and support others. If you enjoy today's show, please subscribe for all episodes and leave a review to help others join our conversations. Have a question for the host or guest? Are you looking to become a show partner? Email Danica at PodcastsByLanci@gmail.com to get connected.CRISIS LINE: DIAL 988

Did you know that your liver performs over 500 vital functions in your body? Join us for an eye-opening episode of the Ancient Health Podcast as host Courtney Bursich interviews Kristin Kirkpatrick, a renowned Registered Dietitian and liver health expert. Kristin, author of "Skinny Liver" and "Regenerative Health," shares her invaluable insights on the crucial role of the liver in metabolic health and overall well-being. In this episode, we delve deep into the world of liver health, exploring its impact on everything from energy levels to cognitive function. Discover: The hidden signs of liver dysfunction you might be overlooking Why your waistline could be a window into your liver's health The surprising link between your liver and unexplained mood swings How fasting might be the key to regenerating your liver cells The truth about detox diets and what really helps your liver Why spending time in nature could be as important for your liver as what's on your plate The sleep-liver connection you never knew existed Tune in to arm yourself with practical, actionable strategies to support your liver's health. Whether you're looking to boost your energy, clear brain fog, or simply optimize your overall health, this episode is packed with game-changing information you can't afford to miss. By the end, you'll walk away with a roadmap to revitalize your liver and transform your health from the inside out. #liverhealth #metabolichealth #nutrition #wellness #detox #functionalmedicine #healthyliving Want more of The Ancient Health Podcast? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Follow Dr. Chris Motley Instagram Follow Courtney Bursich Instagram Follow Kristin Kirkpatrick Instagram ------  Links:  Kristinkirkpatrick.com ------  Ads: *Subscribe to The Dr. Josh Axe Show wherever you listen to your podcasts to take your mental, spiritual, and physical health to the next level! Grab your free Healing Leaky Gut and Essential Oils 101 course at www.joshaxe.com/podcast for a limited time!

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Julia Wattacheril is a physician scientist and director of the Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) program at Columbia University Irving Medical Center. In this episode, Julia delves deep into the complex world of liver health, beginning with a foundational overview of liver physiology. She provides an in-depth look at how alcohol impacts liver function, breaking down the metabolism of ethanol and its detrimental effects. Julia then shifts the focus to understanding liver function tests and optimal enzyme levels, providing a detailed explanation of AST and ALT and elucidating why fluctuations in these levels may or may not be concerning. She provides a primer on the four major stages of liver disease, discussing risk and emphasizing the importance of early diagnosis. Julia highlights the role of liver disease in increasing the risk of cancer and cardiovascular disease and covers in detail the various strategies for diagnosing, treating, and preventing the progression of liver disease. We discuss: Julia's training, the importance of liver health, and the challenges and innovations of hepatology [3:15]; The complex and crucial functionality of the liver, its four most essential functions, and more [8:45]; Liver injuries: historical and evolving understanding of causal factors, and the progression to liver diseases and cancer [13:15]; How the liver metabolizes nutrients and what happens in the presence of excess calories or alcohol [24:45]; Methods of diagnosing liver disease and how insights guide treatment and management strategies [33:30]; The poisonous nature of ethanol to the liver [40:30]; Varied responses to alcohol, damaging effects of alcohol beyond the liver, and the process of advising patients on their alcohol consumption [47:15]; Understanding liver enzymes AST and ALT—interpreting levels, lifestyle factors that affect them, and diagnostic approaches [58:30]; Interpreting liver function tests for fatty liver disease, and the challenges of diagnosing liver pathologies, particularly in children versus adults [1:13:15]; Comprehensive liver health assessments via imaging and various diagnostic tools to prevent overlooking potential liver pathologies [1:18:45]; Potential impact of recreational drugs, statins, and other medications on liver function test results [1:26:45]; Shifting nomenclature from NAFLD to MASLD to reflect accuracy in the underlying pathophysiology and understanding of liver diseases [1:30:30]; Pathophysiology of MASLD, the need for proactive screening, and the significance of liver fat percentage as an indicator of metabolic health [1:36:30]; The importance of screening for rare conditions alongside common metabolic diseases associated with fatty liver accumulation [1:42:45]; Practical strategies for managing MAFLD [1:45:30]; The impact of fructose consumption on liver health and the challenges of disentangling its effects from other factors like obesity and insulin resistance [1:52:45]; The potential of GLP-1 agonists for the treatment of MASLD [1:57:45]; How the four stages of liver disease have evolved [2:00:30]; Increased cancer and heart disease risk associated with early-stage MAFLD [2:05:15]; Emerging drugs and therapies for addressing fat accumulation and fibrosis related to MAFLD [2:12:15]; Peter's major takeaways [2:18:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube