Podcasts about pancreatic

CME credits: 0.25 Valid until: 16-04-2026 Claim your CME credit at https://reachmd.com/programs/cme/second-line-chemotherapy-options-in-metastatic-pdac/33136/ Pancreatic ductal adenocarcinoma, also known as PDAC, is a lethal disease that is usually diagnosed at an advanced stage with an extremely poor prognosis. Advancements in treatment regimens have improved survival rates, but early diagnosis is crucial for improving outcomes, and awareness of risk factors is vital for early diagnosis. Cytotoxic chemotherapy is the cornerstone of treatment for advanced or metastatic cases, although molecularly targeted therapies and immunotherapies may benefit select patients. Treatment selection depends on several factors, including patients' performance status and comorbidities, which should be considered alongside the efficacy and safety profiles of the different chemotherapy regimens. This two-part programme provides an overview of the different first- and second-line chemotherapy options. Complete both modules, answer pre- and post-test questions and start earning CME credits. This programme is also featured on the COR2ED website, here: Chemotherapy Strategies for Metastatic Pancreatic Ductal Adenocarcinoma

CME credits: 0.25 Valid until: 16-04-2026 Claim your CME credit at https://reachmd.com/programs/cme/first-line-chemotherapy-options-in-metastatic-pdac/33135/ Pancreatic ductal adenocarcinoma, also known as PDAC, is a lethal disease that is usually diagnosed at an advanced stage with an extremely poor prognosis. Advancements in treatment regimens have improved survival rates, but early diagnosis is crucial for improving outcomes, and awareness of risk factors is vital for early diagnosis. Cytotoxic chemotherapy is the cornerstone of treatment for advanced or metastatic cases, although molecularly targeted therapies and immunotherapies may benefit select patients. Treatment selection depends on several factors, including patients' performance status and comorbidities, which should be considered alongside the efficacy and safety profiles of the different chemotherapy regimens. This two-part programme provides an overview of the different first- and second-line chemotherapy options. Complete both modules, answer pre- and post-test questions and start earning CME credits. This programme is also featured on the COR2ED website, here: Chemotherapy Strategies for Metastatic Pancreatic Ductal Adenocarcinoma

Pancreatic cancer is one of the deadliest types of cancer. It's known as the “silent killer” because, by the time you know you have it, it's often too late. Pay attention to these 7 early warning signs of pancreatic cancer.1. Sudden unexpected weight lossA problem with the pancreas can affect digestion and appetite, which can cause you to lose weight unexpectedly. 2. Abdominal painThis is typically dull, persistent pain that can radiate to the left shoulder. Sometimes, it shows up as radiating pain in the belly button that extends into the spine and often feels worse after eating. 3. Jaundice This is characterized by yellowing of the whites of the eyes and rust-colored urine caused by bile backing up into the blood. TUDCA can be a good remedy for this! Take two on an empty stomach twice a day to open the bile ducts. 4. Chronic diarrhea Most pancreatic cancer affects the part of the pancreas that is responsible for digestive enzymes, which can often lead to chronic diarrhea. 5. Diabetes A tumor in the pancreas can disrupt the cells that produce insulin, contributing to diabetes. 6. Feeling full quickly Pancreatic cancer can cause you to feel full and bloated even If you've hardly had anything to eat.7. Persistent fatigue This can be described as overwhelming, chronic fatigue that doesn't improve with more sleep.Don't consume sugar if you have pancreatic cancer!Risk factors for pancreatic cancer include the following:•Smoking tobacco •Type 2 diabetes •Obesity •Alcohol consumption•Genetic factors•Vitamin D deficiency Vitamin D may help shrink cancer and enhance the immune system's ability to fight cancer.To help prevent pancreatic cancer:•Ensure you're getting enough sleep •Reduce stress•Exercise •Practice intermittent fasting Incorporating anti-cancer foods such as cruciferous vegetables, green tea, garlic, and berberine may help. Dr. Eric Berg DC Bio:Dr. Berg, age 59, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media.

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Dr Charlie Andrews talks to Dr John Leeds. John Leeds is a Consultant Pancreaticobiliary Physician and Endoscopist based at the Freeman Hospital in Newcastle and an Honorary Clinical Senior Lecturer based in the Population Health Sciences Institute at Newcastle University. He is involved in research in pancreaticobiliary disorders including benign and malignant conditions as well as outcomes from therapeutic/advanced endoscopy.John is a member of the British Society of Gastroenterology and Pancreatic Society of Great Britain and Ireland. He serves on the endoscopy and Pancreas committees for BSG and is the website lead for PSGBI.He is also a founder member of the BSG Pancreas Clinical Research Group which is coordinating research for the society.Key Learnings from this episode:Challenges in Early Detection of Pancreatic Cancer • Pancreatic cancer is often diagnosed at an advanced stage due to the deep location of the pancreas and the lack of early symptoms. • Tumors in the body and tail of the pancreas can grow significantly before causing symptoms, often invading major arteries or veins, making them inoperable. • Tumors in the head of the pancreas may present earlier due to bile duct obstruction, leading to jaundice, but even these are often detected late. Early Symptoms and Red Flags • Early symptoms are vague or absent, making early diagnosis difficult. • Possible early indicators include: • Weight loss (often a sign of advanced disease). • New-onset diabetes, particularly in individuals with a normal BMI or without typical risk factors for type 2 diabetes. • Jaundice, which is a significant red flag and often indicates a serious underlying condition. • Classic signs like painless jaundice and Courvoisier's sign (palpable gallbladder) are important but not always present. Limitations of Current Screening Methods • There is no reliable biomarker or screening test for pancreatic cancer: • CA19-9 is not suitable as a screening tool due to its lack of specificity (elevated in other conditions). • Imaging techniques like CT scans or MRIs are used but have limitations, including incidental findings that may lead to unnecessary anxiety (“scanxiety”) and over-investigation. • Screening is currently limited to high-risk groups, such as those with familial pancreatic cancer syndromes or hereditary pancreatitis. High-Risk Groups for Screening • Familial pancreatic cancer accounts for less than 10% of cases. Criteria for screening include: • Multiple family members with pancreatic cancer, especially diagnosed under age 50–60. • Genetic syndromes like BRCA mutations, familial adenomatous polyposis (FAP), and Peutz-Jeghers syndrome. • Hereditary pancreatitis patients have an increased risk but are harder to screen due to pre-existing pancreatic abnormalities. Emerging Research and Future Directions • Studies are exploring potential biomarkers, such as microbiome signatures in the pancreas, which might help identify high-risk individuals in the future. • Trials like the EuroPAC study focus on surveillance protocols for high-risk individuals using imaging techniques like MRI or endoscopic ultrasound. • Research into new-onset diabetes as a potential marker for pancreatic cancer is ongoing but currently has a low yield due to the high prevalence of type 2 diabetes unrelated to malignancy. Considerations for Screening and Surveillance • Screening should be carefully targeted to avoid over-diagnosis and unnecessary investigations. • The psychological impact of screening (e.g., anxiety from incidental findings) must be considered. • Smoking cessation is emphasized as smoking is a significant risk factor for pancreatic cancer. Advances in Treatment Approaches • PET-CT scans are increasingly used to detect systemic disease that might not be evident on standard CT scans. • Neoadjuvant treatments (therapy before surgery) are being... Chapters (00:00:00) - Ingest(00:00:53) - Pancreatic Cancer(00:04:03) - New diabetes and pancreatic cancer(00:08:01) - Pancreatic Cancer: Screening(00:15:42) - Determining breast cancer early is hard(00:16:03) - Pulmonary neuroendocrine tumors of the pancreas(00:22:26) - Pancreatic cancer 20, Management(00:29:00) - Pancreatic cancer, management principles(00:33:48) - Primary Care Take Home: Pancreas, pain(00:40:29) - Primary Care: Pancreas Cancer Episode 2

Dr Charlie Andrews talks to Dr John Leeds. John Leeds is a Consultant Pancreaticobiliary Physician and Endoscopist based at the Freeman Hospital in Newcastle and an Honorary Clinical Senior Lecturer based in the Population Health Sciences Institute at Newcastle University. He is involved in research in pancreaticobiliary disorders including benign and malignant conditions as well as outcomes from therapeutic/advanced endoscopy.John is a member of the British Society of Gastroenterology and Pancreatic Society of Great Britain and Ireland. He serves on the endoscopy and Pancreas committees for BSG and is the website lead for PSGBI.He is also a founder member of the BSG Pancreas Clinical Research Group which is coordinating research for the society. Chapters (00:00:01) - Ingest: pancreatic lesions(00:01:09) - Pancreas(00:05:39) - Chronic Pancreas disease, early signs and symptoms(00:11:54) - Pulmonary pancreatitis, diagnosis and management(00:17:52) - Diarrhea, weight loss(00:18:29) - Pancreatic disease, ultrasound and the best treatment(00:23:49) - Pancreatitis, chronic pancreatitis in primary care(00:26:19) - Pancreatitis 20, Surgery or drainage?(00:32:24) - Pancreatic Exocrine Insufficiency(00:38:05) - Pulmonary dysrhythmias, management tips(00:43:46) - PPI for cystic fibrosis patients 8,(00:46:16) - Pancreatic insufficiency 20, Detection and treatment(00:49:57) - Pancreatic cysts(00:55:32) - Choosing the right cyst for surgery(00:57:20) - autoimmune pancreatitis, presentation and treatment(01:03:34) - Pancreatic cancer: diagnosis and treatment(01:06:14) - Pancreatitis, part 1, unboxing

Cancer is not a singular disease but a category of hundreds, even thousands, of rare diseases with different molecular signatures and genetic roots. Cancer scientists are looking for a thousand perfect keys to pick a thousand stubborn locks. Today's episode is about the hardest lock of them all: pancreatic cancer. Cancer's power lives in its camouflage. The immune system is often compared to a military search and destroy operation, with our T cells serving as the expert snipers, hunting down antigens and taking them out. But cancer kills so many of us because it looks so much like us. Pancreatic cancer is so deadly in part because it's expert at hiding itself from the immune system. Now, here's the good news. This might be the brightest moment for progress in  pancreatic cancer research in decades—and possibly ever. In the past few years, scientists have developed new drugs that target the key gene mutation responsible for out of control cell growth. Recently, a team of scientists at Oregon Health and Science University claimed to have developed a blood test that is 85 percent accurate at early-stage detection of pancreatic cancer, which is absolutely critical given how advanced the cancer is by the time it's typically caught. And last month, a research center at Memorial Sloan Kettering published a truly extraordinary paper. Using mRNA technology similar to the COVID vaccines, a team of scientists designed a personalized therapy to buff up the immune systems of people with pancreatic cancer. Patients who responded to the treatment saw results that boggle the mind: 75 percent were cancer-free three years after their initial treatment. Not just alive, which would be its own minor miracle. But cancer-free. The mRNA vaccine, administered within a regimen of standard drugs, stood up to the deadliest cancer of them all and won. Today's guest is the head of that research center, the surgical oncologist Vinod Balachandran. The concept of a personalized cancer vaccine is still unproven at scale. But if it works, the potential is enormous. But again: Cancer does not exist, as a singular disease. Cancer is a category of rare diseases, many of which are exquisitely specific to the molecular mosaic of the patient. Cancers are personal. Perhaps in a few years, our cures for cancers will be equally personalized. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Vinod Balachandran Producer: Devon Baroldi Links:  Cancer Vaccine paper: https://www.nature.com/articles/s41586-024-08508-4 P.S. Derek wrote a new book! It's called 'Abundance,' and it's about an optimistic vision for politics, science, and technology that gets America building again. Buy it here: https://www.simonandschuster.com/books/Abundance/Ezra-Klein/9781668023488 Plus: If you live in Seattle, Atlanta, or the Raleigh-Durham-Chapel Hill area, Derek is coming your way in March! See him live at book events in your city. Tickets here: The Abundance Book Tour Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode, we detail the pathophysiology of intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions and overlap. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms, including gastric acid secretion, pancreatic enzymatic activity, bile flow, intestinal motility, and more.Topics:1. Introduction- Overview of intestinal methanogen overgrowth (IMO), hydrogen sulfide-dominant SIBO, and hydrogen-dominant SIBO  - Discussion of overlap  2. Intestinal Methanogen Overgrowth (IMO)- Characterized by an overabundance of methane-producing archaea  - Methane and intestinal transit- Bloating, abdominal discomfort, constipation  - Associated with irritable bowel syndrome with constipation (IBS-C)   3. Overlap Between IMO and SIBO Subtypes- Hydrogen as a substrate for methane and/or hydrogen sulfide production- Shared potential root causes 4. Small Intestinal Bacterial Overgrowth (SIBO) and Protective Mechanisms- The small intestine remains relatively free of bacteria due to protective mechanisms  - Gastric acid secretion - Pancreatic enzymes and bile - Intestinal motility- Structural abnormalities 5. Hydrogen-Dominant SIBO - Increased hydrogen and intestinal transit- Potential symptoms, diarrhea, postprandial bloating  - Different forms of SIBO can coexist  6. Hydrogen Sulfide-Dominant SIBO - H₂S and intestinal motility- H₂S and intestinal epithelial integrity- Symptoms, associations with IBS diarrhea    7. Host Defense Mechanisms Regulating Microbial Balance- Gastric acid secretion, pancreatic enzyme activity, bile flow, intestinal motility, and more 8. Gastric Acid and Its Role in Microbial Regulation- Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor  - Chief cells secrete pepsinogen, conversion into pepsin in acidic conditions  - Gastric acid, digestion and antimicrobial defense   9. Hypochlorhydria - Low gastric acid impairs microbial defense- Reduced acidity disrupts digestion and downstream pancreatic enzyme and bile release   10. Pancreatic Enzymes and Their Role in Microbial Regulation- Pancreatic enzymes, digestion, antimicrobial activity - Enzymes modify chyme to limit fermentable substrates that fuel microbial proliferation   11. Intestinal Motility - Coordinated contractions propel food, microbes, and waste through the GI tract  - The enteric nervous system (ENS) and gut motility- The myenteric plexus controls peristalsis, while the submucosal plexus regulates secretion and absorption   12. Conclusion- Intestinal methanogen overgrowth (IMO), hydrogen-dominant SIBO, and hydrogen sulfide-dominant SIBO - Overlap in symptoms and microbial interactions  - Host defense mechanisms, including gastric acid, pancreatic enzymes, and motility  - Intestinal motility and ENS function in microbial homeostasis  - Hydrogen sulfide as a gasotransmitterThank you to our episode sponsors:1. Shop ⁠⁠⁠⁠⁠Fresh Press Farms⁠⁠⁠'⁠⁠⁠⁠Peach Cider Vinegar⁠⁠ at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠. 2. Shop ⁠CYLN's⁠ full skincare line ⁠here⁠.Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Alicia is a passionate life enthusiast whose perspective was profoundly transformed by her experience with Stage 3 Pancreatic cancer in April 2021. There were ups and downs every step of the way, there were many teachings and challenges. She had 7+ hour robotic Whipple surgery with a very challenging recovery followed by chemotherapy. During her treatment and recovery Alicia adopted all 10 of the Radical Remission Healing Factors. She believes that if cancer hadn't knocked on her door, she would have never changed. She never would have felt so much happiness by watching a sunset or a sunrise, sharing experiences in the physical with the people she loves, or the simple pleasures in life like a great cup of warm tea in her hands on a chilly morning. Today, Alicia cherishes her time with Picasso, her beloved horse, and enjoys invigorating walks and heartwarming conversations with her dog, Tequila-Pepper. However, her greatest joy comes from sharing every day with her husband, Per, as they navigate life's journey together as co-conspirators.  To connect with Alicia you can email her - avila.alicia@gmail.com Resources: www.cognomovement.com  https://pancreasfoundation.org/patient-resources/camp-hope/ ________________ To learn more about the 10 Radical Remission Healing Factors, connect with a certified RR coach or join a virtual or in-person workshop visit www.radicalremission.com. To watch Episode 1 of the Radical Remission Docuseries for free, visit our YouTube channel here.  To purchase the full 10-episode Radical Remission Docuseries visit Hay House Online Learning. To learn more about Radical Remission health coaching with Liz or Karla, Click Here Follow us on Social Media: Facebook  Instagram YouTube  

This ASPEN podcast series is based on the Nutrition in Clinical Practice Supplement titled ‘Fat Malabsorption in Disease States' published in April 2024. This episode features David Evans, MD, focusing on exocrine pancreatic insufficiency related to pancreatectomy and other gastrointestinal surgery. This podcast series provides an in-depth look at the latest understanding of fat malabsorption in various disease states and was developed to educate clinicians on the current evidence in the management of this condition. This podcast is supported by Alcresta. Business Corporate by Alex Menco | alexmenco.net Music promoted by www.free-stock-music.com Creative Commons Attribution 3.0 Unported License creativecommons.org/licenses/by/3.0/deed.en_US March 2025

This ASPEN podcast series is based on the Nutrition in Clinical Practice Supplement titled ‘Fat Malabsorption in Disease States' published in April 2024. This episode features Amy Berry, MS, RD, focusing on exocrine pancreatic insufficiency and management with pancreatic exocrine replacement therapy. This podcast series provides an in-depth look at the latest understanding of fat malabsorption in various disease states and was developed to educate clinicians on the current evidence in the management of this condition. This podcast is supported by Alcresta. Business Corporate by Alex Menco | alexmenco.net Music promoted by www.free-stock-music.com Creative Commons Attribution 3.0 Unported License creativecommons.org/licenses/by/3.0/deed.en_US March 2025

Sweden's fastest growing private biotech, Anocca, is making plans for clinical trials in pancreatic cancer, with the TCR-T cell therapy trials called VIDAR-1.The CEO, Reagan Jarvis, when a researcher, pitched the company idea to a leading Swedish industrialist, who became co-founder, and provided the initial financing. The company has raised more than €100m to date.On the podcast this week, we have a conversation with Jarvis about TCR-T cell therapies, creating off-the-shelf products and partnerships with EmendoBio and Shinobi Therapeutics.00:43-02:10: About Anocca 02:10-04:16: About TCR-T cell therapies and their use in treatments04:16-06:02: Anocca's approach to T-cell biology, cutting-edge biotechnologies and integrated software06:02-07:58: A different approach to other cell and gene therapy companies07:58-09:16: Facing challenges09:16-10:48: Addressing conditions and diseases10:48-11:54: Pancreatic cancer11:54-13:40: What represents success for Anocca?13:40-14:09: What is VIDAR-1?14:09-16:08: Partnerships16:08-18:05: Scaling up and addressing costs18:05-20:07: How is TCR-T therapy evolving?20:07-23:11: The impact of artificial intelligence23:11-25:16: Anocca timeline25:16-25:57: Closing comments  `Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletter

Pancreatic cancer is notoriously difficult to treat, and about 90% of diagnosed patients die from the disease. A team at Memorial Sloan Kettering has been working to improve those outcomes by developing a new mRNA vaccine for pancreatic cancer.A few years ago, the team embarked on a small trial to test the vaccine's safety. Sixteen patients with pancreatic cancer received it, and even though it was a small study, the results were promising: Half the participants had an immune response, and in those patients the cancer hadn't relapsed after 18 months.This week, the team released a new study in Nature following those same patients, and found six out of eight who responded to the vaccine in the first study did not have their cancer return more than three years later.Joining host Flora Lichtman to talk about these results, and what they could mean for the future of cancer treatment, is study author and surgeon Dr. Vinod Balachandran, director of The Olayan Center for Cancer Vaccines at Memorial Sloan Kettering, based in New York City.Transcripts for each segment will be available after the show airs on sciencefriday.com.  Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

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Speaking of SurgOnc® has a new home! New episodes can now be found under the Society of Surgical Oncology's podcast, SurgOnc Today®, available on all major podcast platforms. Subscribe today to receive updates on new episode releases.  In this new episode of Speaking of SurgOnc®, Dr. Rick Greene discusses with Dr. Mark Truty the prognosis, and response to neoadjuvant chemotherapy, of resected invasive intraductal papillary mucinous cystic neoplasms compared with de novo pancreatic ductal adenocarcinoma, as reported in their article, "Outcomes of Neoadjuvant Chemotherapy for Invasive Intraductal Papillary Mucinous Neoplasm Compared with de Novo Pancreatic Adenocarcinoma."

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CME credits: 0.25 Valid until: 13-01-2026 Claim your CME credit at https://reachmd.com/programs/cme/diagnosis-and-management-of-metastatic-pdac/26434/ Pancreatic ductal adenocarcinoma, otherwise known as PDAC, is a lethal disease which is usually diagnosed at an advanced stage and has an extremely poor prognosis. Advancements in treatment regimens have improved survival rates, but early diagnosis is crucial for improving outcomes and awareness of risk factors is vital for early diagnosis. Cytotoxic chemotherapy is the cornerstone of treatment for advanced or metastatic cases, although molecularly targeted therapies and immunotherapies may benefit select patients. Treatment selection depends on several factors, including patients' performance status and co-morbidities and these should be considered alongside the efficacy and safety profiles of the different chemotherapy regimens. This 2-part microlearning provides an overview of the risk factors, diagnostic tools and treatment options available to date for different patient groups. Complete both modules, answer pre- and post-test questions and start earning CME credits. This programme is also featured on the COR2ED website, here: Metastatic pancreatic ductal adenocarcinoma (PDAC): from diagnosis to treatment

CME credits: 0.25 Valid until: 13-01-2026 Claim your CME credit at https://reachmd.com/programs/cme/chemotherapy-strategies-for-metastatic-pdac/26435/ Pancreatic ductal adenocarcinoma, otherwise known as PDAC, is a lethal disease which is usually diagnosed at an advanced stage and has an extremely poor prognosis. Advancements in treatment regimens have improved survival rates, but early diagnosis is crucial for improving outcomes and awareness of risk factors is vital for early diagnosis. Cytotoxic chemotherapy is the cornerstone of treatment for advanced or metastatic cases, although molecularly targeted therapies and immunotherapies may benefit select patients. Treatment selection depends on several factors, including patients' performance status and co-morbidities and these should be considered alongside the efficacy and safety profiles of the different chemotherapy regimens. This 2-part microlearning provides an overview of the risk factors, diagnostic tools and treatment options available to date for different patient groups. Complete both modules, answer pre- and post-test questions and start earning CME credits. This programme is also featured on the COR2ED website, here: Metastatic pancreatic ductal adenocarcinoma (PDAC): from diagnosis to treatment

In today's episode, supported by Merus, we had the pleasure of speaking with Alison Schram, MD, about the FDA approval of zenocutuzumab-zbco (Bizengri) for patients with previously treated advanced pancreatic adenocarcinoma or non–small cell lung cancer (NSCLC) harboring NRG1 gene fusions. Dr Schram is an assistant attending physician at Memorial Sloan Kettering Cancer Center in New York, New York.  On December 4, 2024, the FDA granted accelerated approval to zenocutuzumab for the treatment of adult patients with advanced, unresectable, or metastatic pancreatic adenocarcinoma harboring an NRG1 gene fusion who have disease progression on or after prior systemic therapy; and adult patients with advanced, unresectable, or metastatic NSCLC harboring an NRG1 gene fusion who have disease progression on or after prior systemic therapy. This regulatory decision was based on findings from the phase 2 eNRGy trial (NCT02912949), in which patients with pancreatic adenocarcinoma (n = 30) achieved an overall response rate (ORR) of 40% (95% CI, 23%-59%), and a duration of response (DOR) that ranged from 3.7 months to 16.6 months. In the NSCLC cohort (n = 64), the (ORR) of 33% (95% CI, 22%-46%), and the median DOR was 7.4 months (95% CI, 4.0-16.6).  In our exclusive interview, Dr Schram discussed the significance of this approval, key efficacy data from the pancreatic cancer and NSCLC cohorts of eNRGy, and the importance of using RNA-based testing to identify patients with NRG1 fusions. 

FDA D.I.S.C.O. Burst Edition: FDA approval of Bizengri (zenocutuzumab-zbco) for Treatment of adults with advanced unresectable or metastatic pancreatic adenocarcinoma harboring a neuregulin 1 (NRG1) gene fusion with disease progression on or after prior systemic therapy

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/ZDG865. CME/MOC/AAPA credit will be available until November 13, 2025.Renewed Optimism for Personalized Care in Advanced Pancreatic and Extra-Pancreatic Neuroendocrine Tumors: The Evolving Role and Clinical Applications of Emerging Strategies to Improve Patient Outcomes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Exelixis, Inc. and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/ZDG865. CME/MOC/AAPA credit will be available until November 13, 2025.Renewed Optimism for Personalized Care in Advanced Pancreatic and Extra-Pancreatic Neuroendocrine Tumors: The Evolving Role and Clinical Applications of Emerging Strategies to Improve Patient Outcomes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Exelixis, Inc. and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/ZDG865. CME/MOC/AAPA credit will be available until November 13, 2025.Renewed Optimism for Personalized Care in Advanced Pancreatic and Extra-Pancreatic Neuroendocrine Tumors: The Evolving Role and Clinical Applications of Emerging Strategies to Improve Patient Outcomes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Exelixis, Inc. and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/ZDG865. CME/MOC/AAPA credit will be available until November 13, 2025.Renewed Optimism for Personalized Care in Advanced Pancreatic and Extra-Pancreatic Neuroendocrine Tumors: The Evolving Role and Clinical Applications of Emerging Strategies to Improve Patient Outcomes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Exelixis, Inc. and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/ZDG865. CME/MOC/AAPA credit will be available until November 13, 2025.Renewed Optimism for Personalized Care in Advanced Pancreatic and Extra-Pancreatic Neuroendocrine Tumors: The Evolving Role and Clinical Applications of Emerging Strategies to Improve Patient Outcomes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Exelixis, Inc. and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/ZDG865. CME/MOC/AAPA credit will be available until November 13, 2025.Renewed Optimism for Personalized Care in Advanced Pancreatic and Extra-Pancreatic Neuroendocrine Tumors: The Evolving Role and Clinical Applications of Emerging Strategies to Improve Patient Outcomes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Exelixis, Inc. and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/ZDG865. CME/MOC/AAPA credit will be available until November 13, 2025.Renewed Optimism for Personalized Care in Advanced Pancreatic and Extra-Pancreatic Neuroendocrine Tumors: The Evolving Role and Clinical Applications of Emerging Strategies to Improve Patient Outcomes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Exelixis, Inc. and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA information, and to apply for credit, please visit us at PeerView.com/ZDG865. CME/MOC/AAPA credit will be available until November 13, 2025.Renewed Optimism for Personalized Care in Advanced Pancreatic and Extra-Pancreatic Neuroendocrine Tumors: The Evolving Role and Clinical Applications of Emerging Strategies to Improve Patient Outcomes In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Exelixis, Inc. and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

Sometimes all of us have pains all over our bodies and don't understand why. Did you know what kind of pain is associated with each body organ? However, note that this information is of an introductory kind and shouldn't be taken as a strict guide. TIMESTAMPS Heart 0:36 Kidneys 1:00 Small intestine 1:21 Large intestine 1:37 Lungs 1:51 Appendix 2:13 Stomach 2:37 Gallbladder and liver 3:04 Pancreas 3:26 SUMMARY If something is wrong with the heart, a person feels compressing pain in the chest that can spread to the left arm, shoulder blade, and part of the neck.  Kidney pain can sometimes be confused with a simple backache. The difference is that kidney pain is deeper under the ribs, while muscle pain is usually lower. Problems with the small intestine usually cause pain in the navel region. If the pain persists and causes discomfort when bending or walking, don't put off a visit to a doctor. Issues with the large intestine are usually associated with pain in the lower abdomen, closer to the right side.  The lungs themselves don't feel pain due to a lack of nerve endings. But if something's wrong with them, you may feel a dull ache in your chest. The appendix is located in the lower right region of the abdomen, but pain may affect the whole stomach area or its separate parts. The pain may also travel to your right thigh. Other signs of issues with the appendix are nausea, vomiting, fever, and constipation or diarrhea. Gastric problems cause pain in the middle abdominal region above the ribs and can also appear on the same level in the back. Gallbladder and liver problems may cause pain in the upper right region of the abdomen. It can also travel to the same place in the back. Liver issues are also associated with a wide range of symptoms, such as a sour taste in the mouth and jaundice. Pancreatic problems are indicated by pain in the middle part of the upper abdominal region. However, a less intense pain may also travel to the whole stomach. Don't forget to hit the like button below the video, share it with others, and click subscribe to join the Bright Side of life! Subscribe to Bright Side: https://goo.gl/rQTJZz ---------------------------------------------------------------------------------------- Our Social Media: Facebook:   / brightside   Instagram:   / brightgram   5-Minute Crafts Youtube: https://www.goo.gl/8JVmuC  ---------------------------------------------------------------------------------------- For more videos and articles visit: http://www.brightside.me/ Learn more about your ad choices. Visit megaphone.fm/adchoices

The pancreatic anastomosis is often regarded as the “Achilles Heel” of the Whipple operation, as technical failure and leakage is a significant source of perioperative morbidity and mortality. In this episode from the HPB team at Behind the Knife listen in as we discuss the standard techniques for the anastomosis, alternative techniques for the pancreatic anastomosis in patients with aberrant anatomy and/or physiology, key factors to consider when selecting the ideal approach/technique for the anastomosis, and mitigation strategies for leaks.  Hosts Anish J. Jain MD (@anishjayjain) is a current PGY3 General Surgery Resident at Stanford University and a former T32 Research Fellow at the University of Texas MD Anderson Cancer Center. Jon M. Harrison is a 2nd year HPB Surgery Fellow at Stanford University. He previously completed his general surgery residency at Massachusetts General Hospital, and will be returning to MGH as faculty at the conclusion of his fellowship.    Monica M. Dua (@MonicaDuaMD) is a Clinical Professor of Surgery and the Associate Program Director of the HPB Surgery Fellowship at Stanford University. She also serves as also serves as the regional HPB Surgeon at the VA Palo Alto Health Care System. Learning Objectives · Develop an understanding of the standard technical approaches to the pancreatic anastomosis during a Whipple (pancreatoduodenectomy) operation · Develop an understanding of the alternative technical approaches to the pancreatic anastomosis during the Whipple when the standard approaches may not be feasible · Develop an understanding of the key anatomic and physiologic factors in the decision making when selecting the optimal approach for the pancreatic anastomosis · Develop an understanding of possible mitigation strategies in the event of a pancreatic anastomotic leak. Suggested Reading Jon Harrison, Monica M. Dua, William V. Kastrinakis, Peter J. Fagenholz, Carlos Fernandez-del Castillo, Keith D. Lillemoe, George A. Poultsides, Brendan C. Visser, Motaz Qadan. “Duct tape:” Management strategies for the pancreatic anastomosis during pancreatoduodenectomy. Surgery. Volume 176, Issue 4, 2024, Pages 1308-1311, https://pubmed.ncbi.nlm.nih.gov/38796390/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

BUFFALO, NY - November 4, 2024 – A new #casereport was #published in Oncotarget's Volume 15 on October 11, 2024, entitled “A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy.” This case report highlights a remarkable and unexpected response to immunotherapy in a patient with metastatic adenosquamous pancreatic cancer (ASCP), a rare and aggressive form of pancreatic cancer. The study, led by Murtaza Ahmed, Brent K. Larson, Arsen Osipov, Nilofer Azad, and Andrew Hendifar from Cedars-Sinai Medical Center and Johns Hopkins University, provides new hope for ASCP patients, who are traditionally underserved by current treatment options. The team documented a 68-year-old male with metastatic ASCP carrying a KRAS G12C mutation. Unexpectedly, after limited success with standard therapies, the patient's cancer responded significantly to pembrolizumab, a type of immune checkpoint inhibitor, despite the absence of typical markers indicating suitability for immunotherapy. Pancreatic cancer remains one of the most lethal cancer types, with few advancements in effective treatments for its rarer forms, such as ASCP, which accounts for only 1-10% of all pancreatic cancer cases. Traditionally, ASCP has been treated with chemotherapy based on protocols for the more common pancreatic ductal adenocarcinoma, despite the distinct tumor characteristics. This case suggests that ASCP's unique tumor microenvironment may make it more receptive to immunotherapy. Researchers are hopeful that this new understanding will drive clinical trials focused on immunotherapy specifically for ASCP patients, potentially offering new options for those with limited treatment success. “To that point, there is an active multi-center phase 2 trial investigating outcomes and responses to ICI in patients with metastatic or unresectable ASCP or ampullary cancer.” In conclusion, this report signals a potential shift in the treatment of rare and aggressive pancreatic cancer subtypes like ASCP. As oncology increasingly embraces personalized medicine, cases like this one open new avenues for patients who were not responsive to traditional therapies, potentially transforming the management of previously intractable cancers. DOI - https://doi.org/10.18632/oncotarget.28659 Correspondence to - Andrew Hendifar - andrew.hendifar@cshs.org Video short - https://www.youtube.com/watch?v=VnfohGvfMoM Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28659 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, pancreatic cancer, immunotherapy, metastasis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Ahsen Ustaoglu interviews Dr Matthias Brugel on their targeted screening analysis of pancreatic adenocarcinoma risk with organoclorine pesticides from the PESTIPAC study

Dr. Thomas Clancy joins Radio Boston to discuss pancreatic surgery using an operative robot.

Today's guest is my dear friend Brenda Holley. She is a master coach, helping professionals thrive in their careers. She and Paul have been married for eighteen years. She is mom to two adult sons. I've been friends with Brenda for several years, so I was honored when she reached out to me soon after receiving a diagnosis of pancreatic cancer.Pancreatic cancer has a bad reputation because the prognosis is often extremely grim. While she knew this fact, she chose not to entertain it or dwell on it. Instead, she decided she would fight to overcome it.Brenda's positive mental attitude going into this cancer journey would be incredibly helpful. During our interview, Brenda admitted she hadn't made God a priority over the last few years. Her diagnosis changed that. She said, “I leaned into my faith.” Praying healing verses out loud, reading God's Word, and getting quiet were and continue to be Brenda's daily practices.Brenda was eager to share the valuable wisdom she gained during her cancer journey.The book Brenda mentioned in her interview is Charles Capps' book titled God's Creative Power for Healing. It can be purchased on Amazon. Notable quotes from this episode with Brenda Holley: ·         “Unfortunately, it took a really scary experience to put me right back into the Presence of God. And I discovered so much love and support there.”·         Thank God for His faithfulness even when we're not doing a good job. Because He's always there to pick up those pieces, and there's no judgment. There's only love.”·         “I have also found it helpful to read those Scriptures out loud. If you say them, you get to see what you say.”·         “The more you dig in there and study it [Scripture], the richer it gets.”·         “One other thing that I did that I've used a lot is I made a physical list . . . of all the things that showed God's hand on my situation . . . I go back and look at it all the time.”Bible verse: ·         Jeremiah 1:12 “I am watching over My Word to perform it.”·         Hebrews 1:3 “He is upholding all things by the Word of His power.” Connect with Brenda Holley:Her website: https://brendaholley.comOn Facebook: https://www.facebook.com/brenda.holley.946On Instagram:  https://www.instagram.com/coachbrendaholleySend me a COMMENT or QUESTION!

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Ali: Hello Dr.Cabral. Can you please explain low pancreatic elastase on stool test. I have no GI symptoms or diagnosed disease, but out of curiosity ran comprehensive stool analysis, where pancreatic enzymes were low, butyrate producing bacteria were low and a positive h.pylori was found. Can those two be related? What specific food & supplements can I take to increase pancreatic elastase when dealing with h.pylori? Also, what's your stand on clostridium butyricum as a probiotic supplement to increase butyrate production? Thank you     Patrick: Hey dr hope all is well. I know theres certain things you don't like to talk about for certain reasons but i was wondering if you could give some information on getting a tetanus shot. Im 50 and know Its been a while since i have had one. Thanks keep up the great work     Lauren: (Product Review) have you heard of the sanctuary holistic wellness detox? Is it a good option for a detox? Is it normal to see parasites? Or is that too extreme of a detox?     Josh: Good Morning, Re-listening to latest mindpump episode with Dr Stephen Cabral 2332 and he mentions 10 vitality tests but only mentions one that I can find (A full body MRI). Looking to see what the complete list of 10 vitality tests are and if there is any content where this is posted to review. Thanks in advance for any info. Regards, Josh     Anonymous: Hi Dr Cabral, I am a 63 year old female, not overweight, moderate exercise x3/week. High cholesterol runs in my family and mine's been high since my twenties. I just got my bloods back and total cholesterol is 8.3, HDL 1.5 , LDL6.4, Triglycerides normal. Lipoprotein ratio is 0.89. I have always eaten high carb, lots of sugar. My doctor has insisted on putting me on Statins since an ultrasound of my carotic arteries shows minor very soft plaque, lining within normal limits. I have now cut out sugar and added more fish, meat eggs, Omega 3, magnesium and vitamin D. Now I'm worried that the increased protein especially meat and eggs will raise my cholesterol level further. Would Berberine help for cholesterol? I often have low blood sugar so does that matter? Many thanks in advance!   Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3117 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Seizure medication recalled due to wrong strength on carton; Gene therapy gains Fast Track status for Parkinson disease; Dendritic cell vaccine being developed for pancreatic cancer; Generic version of sickle cell disease treatment Endari is made available

Sid Dogra, MD discusses a study characterizing the visibility and diameter of the pancreatic duct and common bile duct on 2D MR images in children without pancreaticobiliary disease. ARTICLE TITLE - Visibility and Size of the Pancreatic Duct and Common Bile Duct on Routine 2D MRI Sequences in Children Without Pancreaticobiliary Disease

“Our health system is $5 trillion today, and we spend 3.5% of that on preventative healthcare,” says Andrew Lacy.  Andrew, the founder and CEO of whole-body imaging company Prenuvo joins us to discuss early detection of cancer and cognitive decline and explain why preventative health care needs an update, plus: -How Prenuvo is different (~04:08) -What does Prenuvo & what does it test for? (~7:38) -What are the limitations? (~9:46) -The most common findings (~12:50) -My personal MRI experience & findings (~15:16) -Pancreatic cancer and why cancer rates are growing (~24:00) -Early biomarkers of dementia (~30:00)  -What about radiation concerns? (~33:30)  -How much does Prenuvo cost? (~34:06) -Why we need more preventative care (~35:58) -Why the current physcial exam is outdated (~37:27) -Why Andrew started Prenuvo (~40:30)  Use discount code MINDBODYGREEN at checkout or visit http://prenuvo.com/MINDBODYGREEN for $300 off your Prenuvo Whole Body scan. Go to shop.mindbodygreen.com/support15 to get 15% off your first order of methylation+. Referenced in the episode:  Prenuvo  Increasing cancer rates amongst young adults How the brain shrinks with age How much money is spent on preventative care in the U.S. We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today's guest Ginger Vieira, tells us everything we need to know about the 5 hormones affected by T1D, which impact weight loss, appetite, and insulin sensitivity. We discuss each of these hormones in detail and the positive lifestyle choices we can make to work WITH our bodies instead of against them. We also candidly discuss using Ozempic for weight management in type ones. This is the stuff no one is taught at diagnosis! Time Stamps:  (04:54) The “Sorority Terms” of cells(6:40) Amalin hormone(7:42) Glucagon hormone & the overproduction of glucose(09:30) Weight management, hunger cues, & hormones(12:00) The role of protein in your diet (12:25) Glucagon continued (12:45) Somatostatin hormone (14:28) The liver and low blood sugar(16:40) Pancreatic polypeptide hormone & insulin sensitivity (22:08) Stress & basal insulin (22:30) The misunderstanding of the “dawn phenomenon”(23:49) Ghrelin hormone (26:45) Why crash diets do not work with T1D(27:42) Why lifestyle is crucial with T1D and caffeine's effect (28:44) The impact of exercise + insulin sensitivity (31:13) Ozempic (35:38) The importance of working with a coach while taking GLP 1 medicationWhat to do now: Follow me @lauren_bongiorno and @riselyhealth on Instagram to stay in the loop for when new episodes drop.Learn more about our 1:1 coaching programs HERE. Find Ginger @gingervieira.t1d and get her books HERE Disclaimer: Nothing you hear on the Reclaim your Rise podcast should be a substitute for personalized professional medical advice. Please always consult your physician or other medical professional before making any changes to your diet, insulin dosages, or healthcare plan. 

Exocrine Pancreatic Insufficiency (EPI) is a condition caused by damage to the pancreas that results in reduced capability to produce or deliver digestive enzymes which break down fats, carbohydrates or proteins — or to a decrease in the enzyme activity in the small intestine. EPI is most commonly associated with chronic pancreatitis (in adults), cystic fibrosis (in children), diabetes (both type 1 and type 2) and other etiologies such as acute pancreatitis, pancreatic cancer or resection, celiac and Crohn's disease. Consequently, individuals with EPI may suffer malnutrition and fat-soluble vitamin deficiency; loss of bone mass; growth and immune deficiencies; and may experience poorer outcomes such as longer hospital stays and lower survival rates of underlying medical conditions secondary to malnutrition. Listen to guests Kimberly Kearns MS, APRN, ANP-BC and Amy Stewart FNP-C discuss EPI on this episode of the official podcast of the American Association of Nurse Practitioners® (AANP), NP Pulse: The Voice of the Nurse Practitioner® Additionally, two new tools are also available on AANP's Tools and Resources page in both the Gastroenterology and in the Pulmonology and Respiratory therapeutic areas: Pancreatic Enzyme Replacement Therapy (PERT) – Patient Guide to diet and lifestyle modifications, and to the self-administration of PERTs to help reduce symptoms including gas, bloating, abdominal pain and diarrhea caused by undigested food in the gut. Diagnosing and Managing Exocrine Pancreatic Insufficiency (EPI) – Provider Resource including evaluation of symptoms and common high-risk conditions, diagnostic testing and management goals combining diet, lifestyle and therapies to reduce symptoms and improve quality of life. Your voice counts here: EPI Podcast Follow Up Survey (surveymonkey.com)   **This podcast is unaccredited.  

Optimal digestion is crucial for overall health and well-being. It ensures that the body efficiently breaks down food into nutrients, which are then absorbed and utilized for energy, growth, and cellular repair. Proper digestion supports a strong immune system, maintains a healthy gut microbiome, and helps prevent gastrointestinal disorders. Additionally, it plays a significant role in mental health, as the gut is often referred to as the "second brain" due to its impact on mood and cognitive function. Therefore, maintaining optimal digestion is vital for sustaining physical and mental health, enhancing quality of life, and preventing chronic diseases. In this episode of The Nutritional Therapy and Wellness Podcast, host Jamie Belz, FNTP, MHC, continues along the journey of digestion, explaining that if someone is not properly digesting their food, they will not be able to absorb and assimilate the nutrients from the foods they are eating, regardless of how healthful those foods are. Jamie brings back another historical audio clip from a lecture initially given by the founder of The Nutritional Therapy Association, Gray Graham. In Episode 10, Gray discussed the optimal function of digestion. This time, he walks you through “Digestive Hell” – the myriad of diseases, conditions, and other unpleasantries that arise from a suboptimal digestive system. The health of the organism is dependent upon the health of the organ systems, which are dependent upon the health of the organs, which is dependent upon the health of the tissues, which is dependent upon the health of the cells, which is dependent upon digestion. Thus, all wellness begins with digestion. Therefore, does all disease stem from digestive dysfunction? Not exactly, but you can eat the healthiest diet possible for your bio-individual needs, and if you're not breaking it down to the necessary molecules your body can utilize, what's the point? Every single cell in all tissues, organs, and systems of an organism relies on the ability to properly absorb nutrients from food. Factors such as stress, poor eating habits, gallbladder removal, and reduced levels of stomach acid (HCl) can hinder digestion. Given the critical role of nutrition in maintaining healthy cells, any disruption in digestion can be harmful in various ways. When the digestive system is compromised, it can lead to a domino effect, impacting the functioning of other bodily systems, 02:35 – Recap of optimal digestion 04:07 – Start of digestive dysfunction 05:23 – “Where's ‘Digestive Hell'?” 06:56 – Distraction, stress, sympathetic state 13:22 – Pancreatic amylase 13:30 – Dysbiosis, yeast, pathogens (Also at 19:50) 13:55 – It's all about acid/pH levels 15:17 – Macronutrient degradation 15:47 – Inputs for the production of HCl  16:20 – Things that cause hypochlorhydria (stress, too much protein, zinc, other nutrient deficiencies, allergies…) 17:13 – Dr. Jonathan Wright, the use of the Heidelberg Test for diagnosis of hypochlorhydria, pH for proper hormone function and enzymatic action 21:37 – Pasteur vs. Bechamp / Microorganisms vs. Terraine (Which is to blame?) 23:34 – Hpylori 26:53 – Heartburn, acid reflux, GERD, ulcers 37:50 – Homework/experiment 39:40 – Chyme into the duodenum, secretin, pancreas, bicarbonate, incomplete digestion, whole food particles in the small intestine 42:11 – Gallbladder, bile, fats, cholecystokinin, liver, fat-free or low-fat diet as the cause of gallstones and gallbladder dysfunction, cholecystectomy (gallbladder removal) 52:06 – Burping up fish oil and delayed release fish oil 55:04 – Undigested proteins, microvilli, leaky gut/gut permeability, immune dysfunction 56:03 – Dr. Natasha Campbell-McBride, healing her autistic child, GAPS Diet 58:04 – Large intestine/colon, ileocecal valve, dysbiosis, inflammation diverticulitis, irritable bowel, Crohn's disease, celiac disease/gluten reactivity, hormones/endocrine system, enzymes, heart health, allergies, butyric acid and foul-smelling feces   Please SUBSCRIBE and Click Here to record a message for Jamie, ask a question, suggest an interviewee, or record an intro for the show!

In this episode of The Luke Coutinho Show, I am honored to bring you an insightful discussion with one of India's leading cancer surgeons, Dr. Ganesh Nagarajan. With a remarkable career spanning over 22 years, he currently serves as the Director of Surgical Oncology (Hepatobiliary, Pancreatic, and Gastrointestinal Cancers) at Nanavati Max Super Speciality Hospital, Mumbai. Join me as we uncover: Lifestyle changes, including westernization, contribute to the rise in certain cancers in urban India Changing patterns of gastric and colorectal cancer and the prevalence of H. pylori infection The incidence of acid reflux among patients due to late-night meals, overeating, and unhealthy lifestyles The rise of fatty liver cases, including non-alcoholic fatty liver disease (NAFLD) and its progression to cirrhosis The role of gut microbiome in GI health and its potential link to cancer development The importance of screenings and stool tests for various types of cancers And much more…

Eat when you can, sleep when you can, and don't F with the pancreas!  What happens when that third rule goes wrong, and why do people say pancreas injuries are like eating crawfish?  Whether you love the pancreas or just the mention of the P-word strikes fear in your heart, or if you just want the answer to the aforementioned questions, join Drs. Cobler-Lichter, Kwon, and Meizoso, as they guide you through all this and more!  Hosts: - Michael Cobler-Lichter, MD, PGY3, University of Miami/Jackson Memorial Hospital/Ryder Trauma Center, @mdcobler (twitter) - Eugenia Kwon, MD, Trauma/Surgical Critical Care Fellow, University of Miami/Jackson Memorial Hospital/Ryder Trauma Center -Jonathan Meizoso, MD, MSPH Assistant Professor of Surgery, 4 years in practice, University of Miami/Jackson Memorial Hospital/Ryder Trauma Center, @jpmeizoso (twitter) Learning Objectives: - Describe the AAST grading system for pancreatic injuries - Come up with a treatment plan for each grade of pancreatic injury - Identify commonly associated injuries with pancreatic trauma -  List potential complications of pancreatic trauma and/or surgery Quick Hits: 1. Pancreas injuries do not all require a trip to the operating room. Low grade injuries should be managed with a trial of nonoperative management if there are no other operative indications 2. CT is the best initial imaging modality, although it has low sensitivity. If there is high concern for a pancreas injury based on mechanism or associated injuries, further investigation is required. 3. Pancreas injuries are like crawfish: suck the head and eat the tail. 4. Injuries to the left of the SMV can generally be treated with distal pancreatectomy and splenectomy, whereas injuries to the right of the SMV are usually drained. 5. Its important to identify and address any concomitant injuries, with duodenal injuries being the most common in higher grade injuries. 6. In the case of the dreaded grade 5 injury, the safe answer is to come back and do your reconstruction at a later time. References 1.     https://www.westerntrauma.org/western-trauma-association-algorithms/management-of-pancreatic-injuries/ 2.     Bassi, Claudio et al. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery, Volume 161, Issue 3, 584 – 591 https://pubmed.ncbi.nlm.nih.gov/28040257/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

Nat Basma is a Kuwait-based nutritionist, entrepreneur, social butterfly, devoted wife, and loving mother. With a large following and loyal clientele, Nat has empowered countless women and men to find balance and shed excess weight. She's helped Mo lose six kilos so far! Despite having pancreatic insufficiency, Nat overcame obesity and has been every size of clothing. From her education in Miami to her return to Kuwait, Nat's story is one of resilience and triumph. She shares her candid thoughts on motherhood, lessons from her father, her opinions on Mounjaro and plastic surgery, and maintaining a strong relationship with her husband, who works in Congo. With health, family, and financial stability as her priorities, Nat embodies a life lived with purpose and balance.0:00 Introductions4:05 Home in Kuwait9:37 Nat's clients and career16:45 Miami and body image19:18 Health turning point26:21 Father and motherhood33:07 Pancreatic insufficiency and impact of stress43:30 COVID and financial lessons1:01:30 Independence, victim mentality1:04:45 Biggest hurdle to losing weight1:06:0 Mo's personal weight journey1:13:30 Nat's healthy routine and habits1:26:58 Happiness, husband, priorities, social media1:35:26 Schooling system, cultural differences, mission1:43:48 Nat's attitude towards business and success1:46:51 Processed food, medial care, pregnancy, influencing1:56:26 Opinion of Mounjaro and plastic surgery2:00:17 Loss, lessons, and love2:13:44 Family, spirituality, instincts, intentions2:18:10 Closing words

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Lisa: Hello Again Dr. Cabral, In addition to having a Mega-stomach & colon along with LIMO, which seems to reoccur, I have IPMN branch cysts on my pancreas which have not changed in the last 6 months so will be monitored annually. I am not sure if this has attributed to my conditions, but I do take a digestive enzyme along with HCL with each meal. I am not sure if I am taking enough, but I take what I can afford. My GI doctors have been stumped by my conditions, but did offer antibiotics for my LIMO, which I am considering because my insurance will cover it and I am out of money. What would you do if you had these conditions?   Anonymous: Hello! I am currently taking the pill form of birth control. I plan to come off of the birth control in about 6 months. I plan to test my hormones at that point to start rebalancing. I also would like to do the Cbo protocol due to excessive gas and bloating I've experienced for several years now. I am wondering if it would be a good idea to do the Cbo protocol while still on the birth control or should I wait until I have come off of it. I know the birth control can have negative affects on my gut so I don't want to slow my gut healing by doing it while still on the birth control. thank you.   Lindsay: Hello,I loved today's episode on rice. I eat a lot of Banza. It's a chickpea rice. what are your thoughts on that? https://www.eatbanza.com/products/chickpea-rice-garlic-olive-oil   Luis: Hi Dr. Cabral, Do you have any thoughts on Monoatomic Gold? How about Colloidal Silver as a daily mouth wash? Thanks   Jessica: Hi Dr. Cabral, I've learned so much from you. Thank you for all you do to empower so many people! My question is on melatonin. I know you've done many episodes on melatonin and are generally a proponent of its usage in moderate amounts. I typically take 2-3 mg per night. But there are a lot of people in the health space who do not think taking melatonin is a good idea. I hear them usually say something about it being a hormone and not wanting to introduce external hormones to the body if you can help it. But I've always found their rationale to be vague. I know you've done so much research on melatonin. Could you articulate the “steel man” argument for why taking 1-5mg of melatonin every night may not be a good idea?   Jessica: One more question on melatonin - Would you advise someone stop taking melatonin when they become pregnant? That seems to be the conventional wisdom because there is little research on it. But, in theory, it seems like melatonin could be useful for calming the mother's central nervous system, improving sleep, providing antioxidants, etc. — all of which would be favorable to the baby.   Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/2928 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Jeffrey: Hello from one of your grateful students, I searched the podcast for info on a product called Transfer Factor, but found no results. I have a potential client who's recovering from chemo / Pancreatic tumor and is taking the product to support immunity. (from Web MD: A transfer factor is a chemical that is taken from a human or animal that has already developed protection (immunity) against a certain disease.) Would love to hear your thoughts on it, also compared to the Immunity Protocol. Thanks!   Zach: Yo, doc C. What's good homie!? I have two questions. First question: did moose Cabral have a middle name? Second question: what is your favorite cookie or cookies if you have more than 1? P.s- you are the man! Thank you for continuously dropping gems of knowledge for all to hear and learn. Keep up the great work! Much appreciated   Angie: My daughter is going on a missions trip to Peru in March. It is suggested that she take typhoid and malaria pills before departure. I would rather not do this. What would a natural recommendation be?   Lauren: Hello! I have lymph nodes in my neck and by my collar bone that have been noticeable for over a year now. When I've been to my primary care doctor she just said it's normal when your body is fighting an infection. But this has been forever! They don't seem to be getting bigger but they also aren't going away. I am also very puffy. I can't do anything to get the puffiness to go away. I did take your inflammation test and I was off the charts with inflammation. I also did the food sensitivity test and the only thing slightly sensitive was sesame, brazil nuts and vanilla. i've stayed away from those and nothing has changed. My doctors have also told me I have very low blood pressure. I'm not sure if any of this is related. Any suggestions? Thanks!   Marisa: Are there any dietary changes or supplements I can implement to help reduce inflammation in my child that has an auto inflammatory condition (PFAPA). Could this be related to his impulsivity/ADHD?   Katarzyna: Hej, My name's Katarzyna and i want to Lose some weight. Can you help me? Kind regards   Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/2921 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Hey Heal Squad, in this insightful episode, we explore a powerful conversation with Pam from Pancreatic Cancer Patient Services, shedding light on the critical role of case managers and their invaluable support for individuals battling pancreatic cancer. Pam shares her journey and experiences, offering vital guidance and discussing the incredible services available for patients and families. Hopeless in 1996: If a long list of celebs can't beat pancreatic cancer back in 1996, then how can anyone and no pancreatic cancer organization exists. Hollywood victims become the saviors: Michael Landon, Patrick Swayze, Joan Crawford, Jack Benny, Donna Reed, Paul Mitchell, Juliet Prowse, and Pavarotti and how their surviving families affected the cause. Millions of dollars later: what has been learned? Pancreatic cancer cells are smart and strong: they build a watermelon rind-like structure that doesn't even need blood flow to survive.  Molecular profiling: helps us look at tissue tumors to see if there are any mutations that allow for better treatment. Reckless chemotherapy: The day of just throwing chemo at cancer in hopes to see what sticks needs to pass. Pancreatic tumors: the different kind of pancreatic tumors. Survival rates: higher now compared to 25 years ago. No harm in having hope: you could be that person who makes it over 10 years. Disregard stats: every person who is diagnosed is a statistic of one: your cancer journey and outcome are your own. Pancare Services helps all patients: if diagnosed, Pancare case managers will help every step of the way. Be pushy and assertive: especially when it comes to doctors. Symptoms: are vague but could include back pain, nausea, indigestion, and in more advanced cases, jaundice. If symptoms are chronic or you have a family history or you smoke or from select prone cultures, then maybe it's time to look deeper. First rule out worst case scenarios: Push doctors to rule out worst-case scenarios first when engaging in diagnosis. Keep talking: the more we talk about this disease, the more we can make people (even those you don't know) aware. HEAL SQUAD SOCIALS IG: https://www.instagram.com/healsquad/ TikTok: https://www.tiktok.com/@healsquadxmaria HEAL SQUAD RESOURCES: Website: https://www.mariamenounos.com Curated Macy's Page: https://www.macys.com/healsquad Rosetta Stone: https://www.rosettastone.com/healsquad 40% off Just Thrive: https://justthrivehealth.com and use promo code: HEALSQUAD 20% off your first 90-day bottle of Just Calm and Just Thrive Probiotic ABOUT MARIA MENOUNOS: Emmy Award-winning journalist, TV personality, actress, 2x NYT best-selling author, former pro-wrestler and brain tumor survivor, Maria Menounos' passion is to see others heal and to get better in all areas of life. ABOUT HEAL SQUAD x MARIA MENOUNOS: A daily digital talk-show that brings you the world's leading healers, experts, and celebrities to share groundbreaking secrets and tips to getting better in all areas of life. DISCLAIMER: This Podcast and all related content [published or distributed by or on behalf of Maria Menounos or Mariamenounos.com] is for informational purposes only and may include information that is general in nature and that is not specific to you. Any information or opinions provided by guest experts or hosts featured within website or on Company's Podcast are their own; not those of Maria Menounos or the Company. Accordingly, Maria Menounos and the Company cannot be responsible for any results or consequences or actions you may take based on such information or opinions. If you have, or suspect you may have, a health-care emergency, please contact a qualified health care professional for treatment.