POPULARITY
Começam as Guerras Gálicas, imortalizadas pelo registro direto de Júlio César em seu livro "De Bello Gallico". Será ele tão bom autor quanto general? Veja bem. Mais. Epi citados: VBMais 79 – Roma, Parte 4 (República Saqueada) VB 07 - Liderança Referências: Comentários sobre a Guerra da Gália -- Júlio Cesar (livro) Asterix - Wikipedia Epis 41 a/b- The Gallic Wars–podcast, The History of Rome The Celtic Holocaust –podcast, Hardcore History Caesar in Gaul - Roman History – Kings and Generals, YouTube (até minuto 35) Caesar vs the Helvetii (58 B.C.E.) - Historia Civilis, YouTube Caesar vs Ariovistus (58 B.C.E.) - Historia Civilis, YouTube The Battle of the Axona (57 B.C.E.) - Historia Civilis, YouTube Júlio César – artigo, Wikipedia Encontre-nos também no: Instagram (@vejabempodcast), Facebook, e YouTube.
Summary Today, I'll review the formulations and research that illustrates the role of medical foods which are a unique classification of formulations that are approved by the FDA. Additionally, I will speak to the potential value of nutraceuticals and supplemental food-derived products in supporting cognitive health in aging individuals at risk for late-onset Alzheimer's disease (LOAD). And what are medical foods? Medical foods are defined products and nutrient formulations that are specifically designed for the dietary management of a disease. Medical food products are regulated by the FDA. Plus, medical foods contain nutrients or food-based therapeutic ingredients that provide a medical or health benefit, and thus the use of "medical" in the term. Three medical foods will be highlighted in today's episode that address three essential aspect of maintaining and optimizing cognitive function as you age—brain rejuvenation, brain protection (neuroprotection) and brain energetics (energy metabolism). With regard to brain rejuvenation, the formulation—Souvenaid® (Fortasyn Connect), which is available in Australia where it is designated as a "Food for Special Medical Purpose", and it is also available in Singapore and parts of Europe. Souvenaid® is a medical nutrition drink that contains a unique blend of ingredients known as Fortasyn® Connect, which is “formulated to support the growth of brain connections”, which means that it supports the synthesis of neuronal and synaptic membranes that are vital in synaptic function. And that is an important point that I cover in The Diabetic Brain in Alzheimer's Disease. The Souvenaid formulation includes omega 3 fatty acids (EPA, DHA), phospholipids, choline, selenium, vitamin E, vitamin C, B12 B6, folic acid and uridine. Several studies and trials have evaluated the benefits of Souvenaid® and in a consensus opinion of those studies published in 2019 it was determined that there was improvement in memory and cognitive performance in patients with MCI and early Alzheimer's disease. Nevertheless, it was also stated that “currently, there is not enough evidence to conclude that Souvenaid® decreases the rate of progression from MCI to dementia.” However, you will often see if you do a search for that product that it is described by a few sources, including the Souvenaid website, that the formulation is suitable “for the early stages of Alzheimer's disease” which is often associated with MCI. And here is why: Several analyses and clinical trials have shown benefits in memory and cognitive performance in patients with MCI and early Alzheimer's disease as the 2019 consensus opinion analyses reported. In the longest randomized clinical trial—3 years— in prodromal Alzheimer's or MCI due to Alzheimer's pathology—the LiPiDiDiet study, patients who were taking Souvenaid once daily for 3 years showed the following outcomes: Slowed the progression of memory and cognitive decline by 60% Reduced brain shrinkage by 33% Reduced the loss of everyday task performance by 45% The LiPiDiDiet study conclusions were: “This multi-nutrient intervention slowed decline on clinical and other measures related to cognition, function, brain atrophy, and disease progression. These results indicate that intervention benefits increased with long‐term use.” Those findings were published in January of 2021. The ingredient profile Souvenaid® formulation is designed for the rejuvenation of the critical membranes that surround the neuron which are particularly beneficial in the function of the synapse. Neuronal cellular membrane integrity is vital for the myriad of synaptic signaling trafficking mechanisms that underlie synaptic plasticity. And that is what Souvenaid® is designed to do—to enhance the formation and function of synapses that are a critical juncture in the communication and transmission between neurons that are central to learning and memory formation. I decided to talk about this formula to emphasize the ingredients and what their combined benefits can do for nourishing and rejuvenation critical brain synapses. Please listen into this episode to hear a my overview on the benefits associated with the Souvenaid ® ingredients. the second formulation— CerefolinNAC®, which like Souvenaid, is composed of two key ingredients L-methylfolate—a bioactive folate, and N-acetyl cysteine. The formula caplet contains L-methylfolate (Metafolin®), Algae-S Powder (Schizochytrium), 2 mg of Methylcobalamin and 600 mg of N-Acetyl-L-Cysteine. (N-acetylcysteine) CerefolinNAC® is a prescription medical food “ formulated to meet the distinctive nutritional requirements of patients with a type of memory loss called mild cognitive impairment (MCI).” CerefolinNAC® is “formulated to meet the distinctive nutritional requirements of patients with a type of memory loss called mild cognitive impairment (MCI).” MCI is considered to be a prodromal stage that may convert to LOAD. Not all individuals with MCI progress to LOAD. CerefolinNAC® provides a bioactive form of folate—methylfolate and methylcobalamin which is a form of B12 that also functions as a methyl donor and is a like folate, a critical nutrient for supporting healthy methylation pathways that includes an efficient metabolism of homocysteine. How important are these B vitamins in cognitive health in aging individuals? Several studies have shown that elevated homocysteine levels are associated with increased brain atrophy, and B vitamin therapy lowers aberrant levels homocysteine—a potentially toxic molecule that is linked to a decrease in brain grey matter which is referred to as brain shrinkage or atrophy. The CerefolinNAC® ingredients are also beneficial for aging individuals at risk, or who have been diagnosed with cardiovascular disease which makes CerefolinNAC® cardio-and neuroprotective. Listen in to hear the rest of the CerefolinNAC® ingredients story. The last medical food overview I cover in this episode is Axona. Axona is a prescription medical food containing a proprietary formulation of medium chain triglycerides (MCTs). MCTs are derived from coconut and palm kernel oils and there are four that are commonly designated in the family of MCTs— caproic acid (C6), caprylic acid (C8), capric acid (C10), and lauric acid (C12). Axona is primarily composed of caprylic acid or C8, which is also referred to as octanoic acid. Research shows the MCTs and particularly C8 and C10 can fulfill a critical need for an energy substrate for the aging brain. MCTs are metabolized to a ketone body—beta-hydroxybutyrate (BHB) in the liver, which provides cells and neurons with an alternative energy source to glucose. I cover this in depth in my book, The Diabetic Brain in Alzheimer's Disease, along with the importance of ketogenic, intermittent fasting and caloric restriction diet therapy that supports and protects mitochondrial energy metabolism in the brain. In today's episode I also briefly share about my favorite nutrients and extracts supplements that are based on a considerable amount of research with regard to benefiting heart and brain health. Remember, anything that is good for your cardiovascular health is also very good for brain. The importance of a healthy heart-brain axis cannot be overemphasized. The same holds true for the gut-brain axis. Here is an overview of my favorite polyphenol, carotenoid and sulforaphane supplements. First, my highly recommended polyphenol extracts available in many supplemental products include many resveratrol extracts, fisetin, grape seed extract, curcumin, genistein, EGCg (Epigallocatechin gallate), luteolin, found in celery and other vegetables, and quercetin. Carotenoid supplements include astaxanthin—found in krill oil products, and lycopene, zeaxanthin and lutein. A study published in May of this year (2022) found that people with the highest levels of the antioxidants—lutein and zeaxanthin and beta-cryptoxanthin (a carotenoid found in oranges, tangerines, mangoes, papaya, and peaches) in their blood were less likely to develop dementia decades later than people with lower levels of these antioxidants. Another recent study (June 2022) determined while men and women eat about the same amount of carotenoids, that the requirements for carotenoids such as lutein and zeaxanthin in women are much higher, due to their increased vulnerability to macular degeneration and LOAD. Another aspect of that vulnerability in women and increased need to more carotenoid intake is they store of these fat-soluble carotenoids in their body fat which makes them less available to the brain. Lastly, sulforaphane which in supplemental form is usually derived from broccoli seed or sprouts is one of the most powerful phytochemicals available in a supplement. Sulforaphane-rich foods include cruciferous vegetables such as kale, spinach and chard, and in broccoli, brussels sprouts, cabbage and other vegetables. Please listen in to my last episode #14 for a more comprehensive overview on food-derived polyphenols, carotenoids and sulforaphane that are abundant in the Mediterranean, MIND and Improved MIND Diet. The polyphenols, carotenoids and sulforaphane found in foods and available as supplements that not only provide antioxidant and anti-inflammatory cardio- and neuroprotection, they also stimulate: neurogenesis, supports synaptic plasticity, improves cerebral blood flow, decreases beta-amyloid aggregation and their neurotoxic effects and supports their degradation (autophagy) and clearance, support metabolic health, selectively function as phytoestrogens and promotes longevity. Ant the same benefits are associated with many vitamins and other nutrients such as B vitamins, glutathione and NAC that I covered here today, and vitamin D, C and E, CoQ10, alpha-lipoic acid and many others. Now, for the most part I've covered in the ingredient-associated benefits of the medical foods and supplements which are an essential component of the cornerstones which I incorporate into my BrainDefend® body-brain health and renewal program—Protect, Rejuvenate and Energize. A reminder to make sure your supplement is a product that's made by a good manufacturer, and one that features proprietary extracts which often includes a delivery system technology to facilitate their absorption. Several studies and analyses over the past years have demonstrated that supplements bought on Amazon have been found to have labels that don't match contents, meaning that the ingredient levels are either non-existent of far below what the label states. Please visit TheAlzheimer'sSolution.com or www.BrainDefend.com if you have a chance to learn more about my book and programs. Sincerely, Ralph Sanchez, MTCM, CNS, D.Hom https://www.TheAlzheimersSolution.com https://www.facebook.com/TheAlzheimersSolution/ https://www.linkedin.com/in/ralph-sanchez/ https://www.instagram.com/alzheimers_solution/ https://twitter.com/RalphSanchez
Today on Cats at Night: John Catsimatidis with guest host Lidia Curanaj discussed the biggest news in today's headlines. George Pataki, Peter King, Richard Weinberg in the studio. Bill O'Reilly, Dean Popps, Bob Unanue, John Bolton, Axona Lada, Craig Eaton joined as guests. Learn more about your ad choices. Visit megaphone.fm/adchoices
Alzheimer's disease is one of the world's leading causes of death, with 50 million people suffering from the disease worldwide. The global pharmaceutical industry has spent billions of dollars on drug R&D but 99% of clinical trials have failed. Part of the reason could be that most drug developers have focused on targeting beta amyloid, a protein that accumulates in the brain of Alzheimer's patients. This approach has not worked out so far, but scientists have been exploring other theories about the disease and developing treatments based on these other theories. Cerecin (formerly known as Accera) is a global healthcare company focusing on developing novel treatments for neurological disorders. Now based in Singapore, CEO Charles Stacey joins us to discuss the challenges of drug R&D in Alzheimer's disease, what is the 'energy theory', and what's next for the private biotech company. Topics we explored: - Why Charles left medical practice to enter the world of venture capital, investing in Cerecin, before now running the company himself - Why Cerecin rebranded from Accera and moved to Asia - The challenges of Alzheimer's disease drug R&D - What is the 'energy theory' behind Alzheimer's disease? - Axona, what is a 'medical food', and updates on the tricaprilin program Follow Cerecin: Website – https://www.cerecin.com/ LinkedIn – https://www.linkedin.com/company/cerecin/ Follow the Asia Healthcare Podcast! https://siryn.co/asia-healthcare-podcast https://anchor.fm/asiahealthcare Twitter: @jchanpharma Music from https://www.jeffcaylor.com/
Dr. Richard Isaacson joins us today. He is the Author of "The Alzheimer's Diet." We will discuss the importance of nutrition, the impact it has on our bodies and a new medical food that has shown in studies to help those with Dementia. The product, Axona, is available now under prescription. ??Contact Information:??Website www.TheADplan.com Two Books: The Alzheimer's Prevention and Treatment Diet and Alzheimer's Treatment and Prevention: A Patient and Family Guide ??Here is the website for Axona http://www.about-axona.com ??Axona on Twitter https://twitter.com/AxonaForAD ??Axona Facebook page http://www.facebook.com/AxonaForAD ? Contact Information: Alzheimer's Speaks Resource Website: https://www.alzheimersspeaks.com/ Keynote Speaker: https://www.alzheimersspeaks.com/event-planners Join The Purple Angel Project: https://www.alzheimersspeaks.com/purple-angel-project Check out Audible www.audibletrial.com/SOCIAL Check out Fresh Books www.gofreshbooks.com/aliveSupport this Show: https://alzheimersspeaks.com/donate-now/See omnystudio.com/listener for privacy information.
Today our guest will be Dr. Richard Isaacson. He is the Author of "The Alzheimer's Diet." We will discuss the importance of nutrition, the impact it has on our bodies and a new medical food that has shown in studies to help those with Dementia. The product, Axona, is available now under prescription. Contact Information: Website www.TheADplan.com Books The Alzheimer's Diet: A Step-by-step Nutritional Approach for Memory Loss Prevention & Treatment Alzheimer's Treatment Alzheimer's Prevention: A Patient and Family Guide Here is the website for Axona http://www.about-axona.com Axona on Twitter https://twitter.com/AxonaForAD Axona Facebook page http://www.facebook.com/AxonaForAD Alzheimer's Speaks Resource Website https://www.alzheimersspeaks.com/ Alzheimer's Team (Clinical Trials) http://alzheimersstudy.com/60.htm Join The Purple Angel Project: https://www.alzheimersspeaks.com/purple-angel-projectSupport this Show: https://alzheimersspeaks.com/donate-now/See omnystudio.com/listener for privacy information.
Today our guest will be Dr. Richard Isaacson. He is the Author of "The Alzheimer's Diet." We will discuss the importance of nutrition, the impact it has on our bodies and a new medical food that has shown in studies to help those with Dementia. The product, Axona, is available now under prescription. There is also a new medical trial being done which is looking for participants. Information on the clinical trial http://clinicaltrials.gov/ct2/show/NCT01741194?term=AC-1204&rank=1 Website www.TheADplan.com BooksThe Alzheimer's Diet: A Step-by-step Nutritional Approach for Memory Loss Prevention & Treatment Alzheimer's Treatment Alzheimer's Prevention: A Patient and Family Guide Here is the website for Axona http://www.about-axona.com Axona on Twitter https://twitter.com/AxonaForAD Axona Facebook page http://www.facebook.com/AxonaForADSupport this Show: https://alzheimersspeaks.com/donate-now/See omnystudio.com/listener for privacy information.
De bakermat van Soissons is deze goede, oude rivier Axona.
Le berceau de Soissons c"est cette bonne vieille rivière Axona.
The birthplace of Soissons is the beautiful old Axona river.