Podcasts about CNS

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: What are the big differences between lifting heavy vs lighter? (2:35) Training your CNS for change. (21:46) The unliftable man. (28:24) Leverage. (29:47) Kids say the darndest things. (32:42) Coaching your son. (33:52) Learning how to lose. (35:45) The science behind Brain.fm. (37:34) Subliminal messaging. (42:58) Social media platforms as weapons. (45:07) The locus of control. (47:40) Correlation of eating grass-fed meat and inflammation. (49:56) #ListenerLive question #1 – How do I maintain a healthy relationship with food and fitness while dealing with SIBO? (55:13) #ListenerLive question #2 – Do you think the root issue here is overtraining, compromising recovery, or more likely a neurological/sensory driver of these asymmetries? (1:05:11) #ListenerLive question #3 – Should I increase calories even though I've been doing this for a year now and continue to bulk, or should I concentrate on cutting still to lose fat? (1:21:16) #ListenerLive question #4 – How much of an impact could HRT (specifically estrogen and testosterone) have on my life, especially body composition and training/lifting goals? (1:30:54) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit Brain.fm for an exclusive offer for Mind Pump listeners. ** Get 30 days of free access to science-backed music. ** Visit Butcher Box for this month's exclusive Mind Pump offer!  ** Available for a limited time, a curated box pre-filled with Mind Pump's favorite cuts — no guesswork! Butcher Box members who sign up through Mind Pump will receive: $20 OFF their first box, Free chicken breast, ground beef, OR salmon in every box for a whole year! ** October Special: MAPS GLP-1 50% off! ** Code GLP50 at checkout. ** Bret Contreras Tempo Hypertrophy IG Video Sal Di Stefano's Journey in Faith & Fitness – Mind Pump TV Johnny Coulon - Wikipedia Attentional modulation of neural entrainment to sound streams in children with and without ADHD The brain in flow: A systematic review on the neural basis of the flow state Resting state fMRI-based brain information flow mapping Mind Pump #912: How to Change Your Mental State with Music Oracle, Silver Lake and MGX will be main investors in TikTok U.S., sources say Visit Seed for an exclusive offer for Mind Pump listeners! **Promo code 25MINDPUMP at checkout for 25% off your first month's supply of Seed's DS-01® Daily Synbiotic** MP Holistic Health Mind Pump #2690: The NEW DIET Everyone Is Using For Fat Loss Visit Transcend for this month's exclusive Mind Pump offer! ** Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN!  Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE! ** Muscle Mommy Movement Mind Pump Podcast – YouTube Mind Pump Free Resources   People Mentioned Bret Contreras PhD (@bretcontreras1) Instagram Denis Roberts (@denis_kokushi) Instagram Jordan Shallow D.C (@the_muscle_doc) Instagram Justin Brink DC (@dr.justinbrink) Instagram LAUREN FITZ, M.D. (@drlaurenfitz) Instagram

The First Lady of Nutrition welcomes Lauren Vaknine, and for anyone living with rheumatoid arthritis, this is a story you won't want to miss. Diagnosed with juvenile RA just before her second birthday, Lauren was wheelchair-bound by 18 with every joint in her body locked. Most people would have lost hope—but not Lauren, and not her mother. Lauren's mom had already defied convention years earlier, saying no to steroids and choosing homeopathy instead. That decision opened the door to a lifetime of natural healing. At 21, Lauren had her own turning point: realizing her recovery was in her hands, she committed to rebuilding her health one choice at a time. Now, more than 11 years in remission, Lauren shares with Ann Louise the practices that made the difference—whole, organic foods instead of processed ones, key supplements like magnesium, cod liver oil, and black seed oil, and daily rituals with turmeric and frankincense that continue to keep her strong. From a child defined by illness to a global voice in holistic health, Lauren's message is both simple and powerful: the body knows how to heal when we give it what it needs. Learn more at laurenvaknine.co.uk The post From Rheumatoid Arthritis to Complete Remission: The Lauren Vaknine Story first appeared on Ann Louise Gittleman, PhD, CNS.

In this episode of The Nurse Practitioner Podcast, Julia Rogers, DNP, APRN, CNS, FNP-BC, FAANP and Douglas Mazurek, MD discuss differentiating and treating respiratory illnesses during cold season.

In this episode, Jesse Gordon-Blake, PhD, delves into the intricacies of medicinal chemistry, particularly focusing on drug discovery for ALS (amyotrophic lateral sclerosis). Jesse explains the process of discovering molecules that modulate biological pathways, the difference between structure-based and phenotype-based drug design, and the role computational methods play in drug development. The conversation also explores the challenges of crossing the blood-brain barrier, the importance of validating target response, and the complexities of progressing from a theoretical compound to preclinical studies. Additionally, Jesse touches on the significance of target product profiles, CNS drug design characteristics, and the iterative nature of medicinal chemistry. He concludes by discussing his current projects at Cortex, including fundraising strategies and timelines for drug development.00:00 Introduction to Medicinal Chemistry00:37 Drug Discovery Approaches02:01 Computational Methods in Medicinal Chemistry03:21 Challenges in ALS Drug Discovery04:23 Blood-Brain Barrier and Drug Design05:29 Key Properties for CNS Drug Design08:58 Day-to-Day in Drug Discovery09:45 Early Stage Drug Development12:28 Validating Drug Targets16:15 From Theory to Animal Testing22:46 Funding and Timeline Considerations25:45 Regulatory and Manufacturing Considerations28:32 Conclusion and Contact InformationDr. Jesse Gordon-Blake is an independent biotechnology and drug discovery consultant with expertise in medicinal chemistry and neurotherapeutics. He has led efforts in small molecule and peptide therapeutic development, AI-enabled drug discovery, and biotech startup formation, and currently serves as the CSO of Cortexa Therapeutics. He earned his PhD in Medicinal Chemistry from the University of Illinois at Chicago, focusing on developing innovative small-molecule enzyme modulators for Alzheimer's disease.https://www.linkedin.com/in/jesse-gordon-blake-phd-52a26274/https://www.cortexatherapeutics.com/Subhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee.For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

Solvonis Therapeutics PLC (LSE:SVNS) Anthony Tennyson talked with Proactive's Stephen Gunnion about the company's progress following its acquisition of Awakn Life Sciences and the advancement of its lead programs targeting central nervous system (CNS) disorders. Tennyson outlined how the acquisition strengthens Solvonis's pipeline, bringing late clinical-stage assets in alcohol use disorder and psychiatry, specifically a joint venture for post-traumatic stress disorder. “With the acquisition of Awakn we're able to acquire linked clinical stage programs within addiction for alcohol use disorder and then acquire the full joint venture program... in Psychiatry for post-traumatic stress disorder,” he said. The company's lead program, SVN-001, is currently in a Phase 3 trial in partnership with the University of Exeter and the UK Department of Health. Recruitment began in July 2024, with results expected in late 2027 or early 2028. Solvonis is in licensing discussions with several pharmaceutical firms for this asset. Tennyson also provided an update on SVN-002, which targets the US market by repurposing J&J's SPRAVATO for alcohol use disorder. The FDA has agreed to a regulatory path that could bypass early-stage trials, significantly reducing costs. Key 2025 milestones include: progressing licensing for SVN-001, establishing a scientific bridge for SVN-002, and declaring a lead candidate for SVN-SDN14. For more videos like this, visit Proactive's YouTube channel. Don't forget to like this video, subscribe, and hit the notification bell to stay updated. #Solvonis #AnthonyTennyson #AlcoholUseDisorder #SVN001 #SVN002 #CentralNervousSystem #BiotechNews #CNSDisorders #DrugDevelopment #PTSDTreatment #PharmaLicensing #SPRAVATO #AwaknLifeSciences #proactiveinvestors

During episode #93 of The Weekly Bioanalysis, John and Dom welcome guest Chris Crean, founder/CEO of Xyzagen, who reflects on three decades in drug development and how the field has shifted from small molecules to today's complex biologics, gene editing, and beyond. Chris explains how Xyzagen helps small, science-driven teams move faster by uniting early discovery “back-office” needs so studies are right-sized and decision-ready. He dives into modern PK design, showing how advances in LC-MS and immunoassays slash sample volumes and enable smarter rodent studies while preserving animal welfare. The conversation covers non-compartmental vs. modeling/simulation approaches and the practical toolset teams actually use plus when tissue distribution and ocular/CNS models matter. Chris also shares collaboration advice and highlights Xyzagen's strengths in ophthalmology, neurology, and specialized routes like intrathecal or intravitreal dosing.“The Weekly Bioanalysis” is a podcast dedicated to discussing bioanalytical news, tools and services related to the pharmaceutical, biopharmaceutical and biomarker industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Senior Scientific Advisors as they chat over coffee and discuss what they've learned about the bioanalytical world the past couple of weeks. “The Weekly Bioanalysis” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.

Friday, September 26, 2025. Week 39.   In #S10e182 I told you about CAMP4, don't miss that, watch here: https://www.youtube.com/watch?v=PZ0Oj-Zz-B0 Sharing research comments from William Blair & Wedbush   William Blair Initiation of Coverage: “Among several quality investors, the private placement included the Syngap Research Fund, which is active in the Syngap1 patient community and will be an important resource in aiding patient identification and enrollment in the Phase 1/2 trial in our view.”   Wedbush Ph1/2 Will Likely Begin From Ex-U.S., Aiming for Early Intervention. Citing precedents of other intrathecally delivered antisense oligonucleotide programs for CNS indications, where the FDA oftentimes required sponsors to begin at a dose level well below the efficacious dose, CAMP plans to begin patient dosing outside the U.S. for the potential to go directly to doses that are expected to show efficacy. The selection of patient age range will depend on regulatory discussions, and management highlighted the impact of the disease on neurodevelopment, so early intervention could allow patients to have a better opportunity to achieve as normal as possible development. CAMP Will Have Access to Natural History Data being Collected by SRF and CHOP. According to management, a natural history study is being conducted by SynGAP Research Fund (SRF), which also participated in the private placement, in collaboration with Children's Hospital of Philadelphia (CHOP), and CAMP will have access to data as well as patients for future clinical study enrollment. Donate now: https://curesyngap1.org/donate/ Beacon of Hope was a great success, raised over $100k.  We need to do this every year.  Thanks to Navarros for getting this launched, also to SJ, Emily Barnes, Peter Halliburton, & Kathryn Helde who helped make this event incredible. Emmy's video (top of) https://curesyngap1.org/resources/movies/ Blog: https://cureSYNGAP1.org/Beacon25 (will be live Friday night 9/26) Pairs well with Gala Blog: https://curesyngap1.org/Gala25  Research is non-stop:  - CRID, get one. https://curesyngap1.org/blog/every-syngap1-related-disorders-patient-needs-a-crid/  - ProMMiS, incredible coordination meeting today.  Sign up. https://curesyngap1.org/resources/studies/syngap1-ProMMiS/  - Sign up for Citizen Health too!  AI Advocate is live for us an awesome. https://www.citizen.health/partners/srf   Episode 183 of #Syngap10 #CureSYNGAP1 #Advocate #PatientAdvocacy #UnmetNeed #SYNGAP1 #SynGAP #SynGAProMMiS

In this live training call from the mini-course: The Missing Link, we build on the foundation from Call #1 and show how to interpret and apply the SI Joint Mobility Locator Test inside real clinical scenarios.What you'll learn in this replay:Why adding a breath hold to your SI joint test is the missing link that reveals visceral, CNS, or neurovascular drivers.The 3-round protocol for assessment + treatment → reassessment, so you stop chasing symptoms and start peeling back protection patterns.Practical treatment options you already know (breathing, spine mobility, self-massage, neuro drills) reframed through the whole-organism paradigm.How to explain the SI joint “traffic cop” test to patients without overcomplicating it.Case scenarios: wrist pain, sciatica, and shoulder pain—all solved by letting the SI joint guide treatment sequencing.Why assessment precision > more treatment tools for achieving outcomes that stick.Anna also shares what's ahead in the full LTAP™ Level 1 Course, opening for enrollment on September 29th, and how this paradigm shift is helping clinicians achieve better results.Considering the viscera as a source of musculoskeletal pain and dysfunction is a great way to ensure a more true whole body approach to care, however it can be a bit overwhelming on where to start, which is exactly why I created the Visceral Referral Cheat Sheet. This FREE download will help you to learn the most common visceral referral patterns affecting the musculoskeletal system. Download it at www.unrealresultspod.com=================================================Watch the podcast on YouTube and subscribe!Join the MovementREV email list to stay up to date on the Unreal Results Podcast and MovementREV education. Be social and follow me:Instagram | Facebook | Twitter | YouTube

In the final episode of this two-part series, Dr. Justin Abbatemarco discusses long-term maintenance therapy options.  Show reference:  https://www.neurology.org/doi/10.1212/CPJ.0000000000200504 

In part one of this two-part series, Dr. Justin Abbatemarco discusses what we know and don't know surrounding MOG antibody–associated diseases (MOGADs).  Show reference:  https://www.neurology.org/doi/10.1212/CPJ.0000000000200504 

In this special episode of Unreal Results Podcast, I share the replay of Live Training #1 from The Missing Link (Fall 2025). You'll learn how one change to your assessment—adding a simple breath hold—reveals whether the viscera, CNS, or peripheral neurovascular system is driving a patient's presentation, so you can stop chasing symptoms and start getting faster, stickier results.What's inside:Why most clinics plateau at 60–80% success—and how to break that ceiling without overhauling your entire approach.LTAP™ overview: 5 orthopedic-based assessments guided by osteopathic principles to pinpoint the true driver (viscera/CNS/peripheral NV vs. MSK).SI joint as the “traffic cop”: A reliable gateway into whole-organism status (and why this isn't just a “low back thing”).Standing March Test walkthrough: Setup, light-touch palpation, what “normal” looks like, and the exact breath-hold cue that changes the result.Interpretation that actually guides treatment: When the breath hold changes the test vs. when it doesn't—and what to do next.Adapting the test for scoliosis, spinal fusion, neuro conditions, and how to handle high-pain states.Join the mini-course this week: https://movementrev.mykajabi.com/the-missing-link-fall-2025Considering the viscera as a source of musculoskeletal pain and dysfunction is a great way to ensure a more true whole body approach to care, however it can be a bit overwhelming on where to start, which is exactly why I created the Visceral Referral Cheat Sheet. This FREE download will help you to learn the most common visceral referral patterns affecting the musculoskeletal system. Download it at www.unrealresultspod.com=================================================Watch the podcast on YouTube and subscribe!Join the MovementREV email list to stay up to date on the Unreal Results Podcast and MovementREV education. Be social and follow me:Instagram | Facebook | Twitter | YouTube

Ben has over 20 years experience across elite sport having been involved in the physical preparation of athletes since 1999. His coaching experience extends across a wide range of sports both professional (AFL and cricket) and Olympic sports including leading the physical preparation for the Australian Beach Volleyball program for the 2013/15/19/21 World Championships and the Rio Olympics and Tokyo Olympics. He has also had extensive experience in coaching developing athletes having worked at ASPIRE Academy and in his current role as Head of Athletic Development at St Peter's College in Adelaide, Australia. He has completed a PhD examining the neuromuscular effects and adaptations to maximal strength and power training and is an ASCA Level 3 and Master Coach and in 2023 was awarded Life Membership to ASCA. QUOTES "What is really clear is the neuro side of the neuromuscular is tough. And for good reason… It's because for a long time, our understanding of the neural system and its impact on performance outcomes, because again, that's what's important for us and our athletes, has not really been well understood." "One of the things that we're starting to discover is that your gaze where you are looking, what you're doing with your eyes is a really powerful tool to help prime, for lack of a better word, your extension movement pattern." "The top one percent that are going on to win medals at Olympic Games versus those that are not, it's not so much the force that they can produce or the force at velocity via their agonist muscles but it's how well they can turn off their antagonists and cycle through multiple movements." "I think what we probably initially started to blame CNS fatigue on was more acute type of fatigue, when probably the only people that start to show significant levels of neuromuscular fatigue from a neural perspective are those that have been chronically overtrained for a significant amount of time" "What I found was that the sprint cyclists had much greater ability to damage themselves, to put themselves into even just a short term performance hole compared with rowers based on the type of training they were doing." SHOWNOTES 1) Ben's background and journey in strength and conditioning 2) Understanding the neural side of neuromuscular training 3) Opportunities in training and practical methods to enhance the neural response to training 4) The priming effect of gaze on different movement patterns and the role of coordination in peformance 5) Periodizing methods to enhance neural responses in strength & conditioning sessions 6) Neuromuscular assessments and Ben's thoughts on neural fatigue 7) The use of electrical muscle stimulation in training and the time course of recovery from high neural load activity based on level of athlete 8) Reframing strength as a skill and countermovement jump numbers in beach volleyball PEOPLE MENTIONED Cal Dietz

In this episode of Raising the Aviation Bar, EUROCONTROL's Véronique Travers Sutter and EASA's Cyrille Rosay explore the growing challenge of GNSS interference across Europe and its impact on aviation safety. They discuss how GNSS supports efficient flight operations, and why its resilience is critical. With interference increasing since 2022, especially near conflict zones, EUROCONTROL and EASA have launched a joint action plan to safeguard CNS infrastructure. The episode highlights technical upgrades, operational tools, and regulatory coordination—all part of a centralised strategy to ensure Europe's aviation system remains safe, robust and future-ready.

In this episode of The Coaching 101 Podcast, hosts Daniel Chamberlain and Coach Kenny Simpson are joined by Dr. Chad Peters to explore the importance of efficiency in sports performance. Dr. Peters shares his extensive experience in college football, chiropractic, and sports performance, emphasizing the need for high school coaches to adopt modern techniques to optimize practice, training, and game prep. The discussion covers revolutionary concepts such as autoregulation in weight training, pre-game CNS priming, and effective return-to-play strategies. The episode underscores the importance of cutting unnecessary elements in training sessions and integrates the role of AI in enhancing coaching efficiency. Additionally, practical advice for handling busy game weeks is provided, highlighting the need for prioritizing and modifying training schedules. This episode is a must-listen for coaches looking to bring state-of-the-art performance techniques to their teams.00:00 Introduction and Guest Introduction00:29 Chad Peters' Background and Career Journey02:12 Professional Development and Coaching Insights05:23 Efficiency in Coaching and Training07:20 Sponsorship and Advertisements13:16 Efficiency in Practice and Weight Room29:48 The Importance of Mobility and Movement31:52 Coaches' Role in Injury Prevention32:57 Efficiency in Coaching Practices38:36 Future Trends in Sports Training52:13 The Role of AI in Coaching54:41 Handling Multiple Games in a Week56:25 Closing Thoughts and Contact InformationDaniel Chamberlain: @CoachChamboOK ChamberlainFootballConsulting@gmail.com chamberlainfootballconsulting.com Kenny Simpson: @FBCoachSimpson fbcoachsimpson@gmail.com FBCoachSimpson.com

Send us a textDr. Brigitte Robertson, MD ( https://www.adial.com/team/brigette-roberston-md/ ) is Chief Medical Officer of Adial Pharmaceuticals, a clinical-stage biopharma company focused on developing therapies for the treatment of addiction and related diseases, specifically Alcohol Use Disorder (AUD). In the U.S. alone, an estimated 35 million people suffer from AUD, resulting in significant health, social and financial costs. Current treatment options present significant barriers to patient adoption including abstinence and side effects which can lead to social stigmatization.Dr. Robertson has nearly 20 years of academic, clinical, and pharmaceutical industry experience. She has managed global development portfolios across multiple CNS indications, mechanisms, and in biotech, small, and large pharma. Her experience spans all phases of development, from the bench to bedside, and she has actively engaged throughout her career in advancing biomarkers to improve translation and trial outcomes (leveraging precision approaches, omics, wearables and AI). She is a scientific advisor to biotech companies, has served on industry and academic consortia and authored numerous articles published in leading peer-reviewed journals.Dr. Robertson's industry career started at GlaxoSmithKline as a physician scientist in translational medicine for the Center for Excellence in Drug Discovery. She subsequently held senior roles in clinical development at Sepracor/Sunovion, Neurovance, Euthymics, and Shire/Takeda, where she served as VP and the Therapeutic Area Head of Neuroscience. In this last role, she led global clinical development and helped drive the disease area strategy for a large portfolio of early and late-stage assets in neurological, psychiatric, and neurodegenerative disorders, resulting in successful approvals across several indications.Dr. Robertson then served as the Chief Medical Officer of Yumanity Therapeutics, and led development of novel small molecule treatments for neurodegenerative diseases. She comes to Adial from Delix Therapeutics, where she most recently served as CMO, setting the strategy and leading clinical development for their portfolio of psychedelic-related analogs targeting the treatment of neurodegenerative disorders, and psychiatric illness including Depression, Anxiety/PTSD, and Substance use.Dr. Robertson completed residency training at the University of Colorado Health Sciences Center, followed by a fellowship in child and adolescent psychiatry and a second post-doctoral research fellowship, sponsored by the NIH in neuroimaging and psychopharmacology at the University of California in San Diego (UCSD). In addition, she has held faculty positions at CCP Children's hospital in San Diego, USCD, and Duke University.#BrigitteRobertson #AdialPharmaceuticals #Addiction #AlcoholUseDisorder #Ondansetron #DrugRepurposing #5HT3Receptor #SingleNucleotidePolymorphisms  #ProgressPotentialAndPossibilities #IraPastor #STEM #Innovation #Technology #Science #Research #Podcast #PodcasterSupport the show

“世界上最遥远的距离不是生与死，而是我站在你面前，你却不再记得我。”遗忘，可能不只是自然衰老，而是一场发生在大脑深处的无声战争—阿尔兹海默病。在中国上千万阿尔兹海默病患者的背后，是无数个家庭在记忆的迷雾中艰难前行。为什么阿尔兹海默病的治疗是一条“单行道”？从Aβ蛋白的学术造假风波，到LVA手术的迅速兴起与紧急叫停，阿尔兹海默病的研究为何困难重重？“早诊早筛”对于阿尔兹海默病的患者意味着什么？每年的9月21日是世界阿尔茨海默病日。 值此时间，本期节目特别邀请到【宛平北路600号】的主播Jerry和IQVIA咨询部副总监Vincent，与我们一起直面记忆的“褪色”，揭开阿尔茨海默病治疗的复杂真相。-嘉宾-Jerry Zhang，播客《宛平北路600号》主播Vincent Liu，IQVIA艾昆纬中国管理咨询部副总监莉莉安，《IQ老友说》主播-精华highlight-02:58 阿尔兹海默病的本质是什么？04:44 仅不到20%的阿尔兹海默病患者会在早期就医05:45 中国的阿尔兹海默病就诊率有望超越海外06:26 神经元的死亡就像是一颗坏掉的鸡蛋，无法再复原07:01 面对阿尔兹海默病的不同疾病阶段，现有疗法如何发挥作用？08:20 目前阿尔兹海默病的药物都以改善症状或延缓疾病发展为主10:12 未来阿尔兹阿默病可能被治愈吗？10:49 CNS领域的理论复杂、研发难、病理假说验证慢，因此其发展较为滞后11:46 阿尔兹海默病的研发是“专属于巨头的游戏”12:46 安慰剂效应、血脑屏障、患者招募难、量表敏感性…都是CNS领域新药研发的常见痛点15:51 关于Aβ淀粉样蛋白的学术造假风波带来了什么影响？17:36 为什么“颈深淋巴管/结—静脉吻合术”被用于阿尔兹海默病的治疗后又被叫停？21:46 畅想阿尔兹海默病治疗的未来，可能采用药物及手术联合治疗22:37 “早诊早筛”可以助力患者的收益最大化26:16 阿尔兹海默病的筛查在技术层面已经非常成熟28:26 国家层面对于阿尔兹海默病的认知管理指日可待30:41 家里有长辈得了阿尔兹海默病，我该提前做基因检测吗？34:48 思路打开，未来可能有哪些疗法？基因治疗AD是否有望实现？*本节目仅做信息交流之目的，嘉宾观点不代表任何公司立场- 制作团队 -沈旸、王心影、束菲滢- IQ老友说 -这是一档IQVIA艾昆纬的谈话类播客节目，聚焦医疗行业，网罗多元视角，激发观点碰撞，探寻新鲜洞见，让我们一起在轻松话聊的氛围中，老友说医疗，有趣又有料！- 关于IQVIA -IQVIA艾昆纬（纽交所代码：IQV）是全球领先的专注生命科学领域的高级分析、技术解决方案和临床研究服务供应商。IQVIA利用深入分析、前沿技术、大数据资源和广泛领域的专业知识，智能连接医疗生态的各个环节。IQVIA Connected Intelligence快速敏锐地为客户提供强大的数据洞察，帮助客户加速创新医疗的临床开发和商业化进程，以更好的医疗成果惠及患者。IQVIA拥有约88,000名员工，足迹遍布100多个国家/地区。IQVIA帮助生物科技、医疗器械、制药公司、医学研究者、政府机关、支付方以及其他医疗利益相关方，获得对疾病、人类行为和科技进步更深入的理解，共同朝着治愈各类疾病的方向迈进。- 互动方式 -关注IQVIA艾昆纬微信公众号，获取更多独家洞察！- 本节目由IQVIA出品，JustPod制作发行 -

In today's episode, we had the pleasure of speaking with Alexander Drilon, MD, about the phase 1/2 ARROS-1 trial (NCT05118789) investigating zidesamtinib (NVL-520) in TKI-pretreated patients with advanced ROS1-positive non–small cell lung cancer (NSCLC). Dr Drilon is chief of the Early Drug Development Service at Memorial Sloan Kettering Cancer Center in New York, New York. In our exclusive interview, Dr Drilon discussed the efficacy data and implications of the ARROS-1 trial, highlighted the unique mechanism of action of zidesamtinib, noted the high central nervous system (CNS) response rates and favorable safety profile associated with the agent, and emphasized the potential for zidesamtinib to become a standard first-line therapy in the NSCLC treatment paradigm, especially for patients with prior TKI resistance or CNS disease.

The First Lady of Nutrition welcomes Zen Honeycutt, founder of Moms Across America and author of Unstoppable: Transforming Sickness and Struggle into Triumph, Empowerment and a Celebration of Community. Together, Ann Louise and Zen take a hard look at the hidden dangers in our food supply—from GMOs and glyphosates to food dyes, pesticides, and heavy metals. You'll be shocked to learn how many toxic additives are banned in Europe yet fully allowed in the U.S., and how testing has revealed disturbing levels of glyphosate, aluminum, and lead in everything from packaged foods to school lunches. Zen and Moms Across America was one of the first citizen-funded glyphosate testing projects in the U.S. They also successfully petitioned Costco to remove Roundup from their shelves. Learn more about this and other research such as the profound impact of real nutrition. In one example, parolees and violent offenders who received proper vitamin and mineral supplementation—or simply switched from processed to whole foods—saw dramatic drops in aggression and recidivism, often in a very short time. Join us and come away with practical tips for clearing glyphosate from your system, a better understanding of why choosing organic and regenerative foods matters, and a reminder that sometimes the smartest strategy is as simple as knowing your local farmer. Learn more about Zen's mission at https://www.momsacrossamerica.com/. The post Toxic Truths About America's Food Supply first appeared on Ann Louise Gittleman, PhD, CNS.

Send us a textHistamine intolerance might feel like the final answer, but what if it's really just the tip of the iceberg?In this episode, Alyssa sits down with Jennifer Fugo, MS, LDN, CNS — a clinical nutritionist and host of the Healthy Skin Show — to uncover the real root causes behind histamine intolerance and chronic skin issues. They uncover why antihistamines don't always help, why low histamine diets often fail long-term, and what hidden root causes could be driving your symptoms instead. From gut infections and parasites to thyroid issues and skin dysbiosis, they dig into the overlooked triggers that keep people stuck in flare cycles.They also talk about the surprising gut-brain-skin connection, why stool tests often miss what's really happening, and the steps you can take to move toward true resilience and food freedom — not just restriction and supplements.Guest BioJennifer Fugo, MS, LDN, CNS is a clinical nutritionist empowering adults failed by conventional medicine to beat chronic skin and gut challenges with a root cause approach. She's the founder of Skinterrupt, creator of Quell supplements and skincare, and host of the Healthy Skin Show podcast with over 1.3 million downloads.Resources & Links:

In this episode of NucleCast, Adam interviews Dr. Rich Tighe, the president and CEO of Consolidated Nuclear Security, discussing the current operations and future outlook of the Y-12 National Security Complex. Rich explains the complex's historical significance, its current missions, and the challenges it faces in workforce recruitment and safety. The conversation also touches on modernization efforts, collaboration with design agencies, and the importance of community support. Rich shares his aspirations for the future, including the need for continued growth and innovation in nuclear security.Richard (Rich) Tighe is president and chief executive officer of Consolidated Nuclear Security, the Bechtel led management and operating contractor for the Y 12 National Security Complex in Oak Ridge, Tennessee, with a workforce of approximately 9,500. Tighe (pronounced “tie”) joined CNS in September 2022, and led the company through the separation of the Pantex Plant from CNS's management and operating contract. Before the separation, Tighe led a combined 13,500 employees through significant growth and record performance. As the National Nuclear Security Administration mission and project scope grew at the sites, CNS met all deliverables to the military under Tighe's leadership. Additionally, during his tenure, CNS added more than 1,500 team members, including engineers, scientists, professional staff, and craft workers, and both sites improved safety performance, achieving more than 12.6 million consecutive hours without a lost time injury. Under Tighe's leadership, CNS has been awarded a 2-year contract extension at Y-12.Before joining CNS, Tighe served for nearly 4 years as president and general manager of National Aerospace Solutions (NAS), the Bechtel-led test operations and sustainment contractor for the Arnold Engineering Development Complex at Arnold Air Force Base near Tullahoma,Tennessee. He also was manager of strategy, marketing, and business development for Bechtel's Nuclear, Security, and Environmental global business unit, an $8 billion business. He served as the NS&E representative to the Bechtel Group Marketing and Business Development Committee and represented Bechtel on the board of managers for NAS and Kwajalein Range Services.Tighe joined Bechtel in 2006 as marketing and business development manager; he was elected principal vice president in 2016 and senior vice president in 2023. Before his service with Bechtel, Tighe worked for Lockheed Martin at the Nevada Test Site for more than a decade, holding several scientific and management posts and ultimately advancing to assistant general manager for high-hazard test and evaluation.Tighe was a postdoctoral fellow in the Nuclear Science Division of the Lawrence Berkeley National Laboratory at the University of California.He earned a Ph.D. in experimental nuclear physics from the University of Notre Dame, Indiana, and a B.S. in physics from Loras College in Dubuque, Iowa.Socials:Follow on Twitter at @NucleCastFollow on LinkedIn: https://linkedin.com/company/nuclecastpodcastSubscribe RSS Feed: https://rss.com/podcasts/nuclecast-podcast/Rate: https://podcasts.apple.com/us/podcast/nuclecast/id1644921278Email comments and topic/guest suggestions to NucleCast@anwadeter.org

On this show Karolyn talks with saliva expert—yes, saliva!—Patti Milligan, PhD, RD, CNS, about how the science of saliva can influence our health. Dr. Milligan is an accomplished author and researcher and has taught corporate wellness programs through the US and Europe. She has even done a TedTalk about how understanding our saliva can help us make informed health decisions. It's time to find out what messages our saliva is sending us!Five To Thrive Live is broadcast live Tuesdays at 7PM ET and Music on W4CS Radio – The Cancer Support Network (www.w4cy.com) part of Talk 4 Radio (www.talk4radio.com) on the Talk 4 Media Network (www.talk4media.com).Five To Thrive Live Podcast is also available on Talk 4 Media (www.talk4media.com), Talk 4 Podcasting (www.talk4podcasting.com), iHeartRadio, Amazon Music, Pandora, Spotify, Audible, and over 100 other podcast outlets.

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Ann Louise Gittleman welcomes Joe Wells—UNI KEY's behind-the-scenes partner in the development of Collagen 4+ and a seasoned entrepreneur with three decades in health and fitness. A former NFL player turned industry innovator, Joe founded Max Muscle and scaled it to nearly 200 franchise stores, launched Max Sports & Fitness magazine, helped develop more than 200 nutrition products, and was honored as Entrepreneur of the Year by the Academy of Bodybuilding, Fitness & Sports. In this fast, plain-English masterclass, Joe demystifies collagen (19 amino acids, grass-fed, hormone-free, animal-derived) and explains why most powders aren't complete proteins. Collagen 4+ fixes that by adding L-tryptophan—so your scoop behaves like a complete protein—then turns up results with vitamin C to drive collagen synthesis, hyaluronic acid (famous for holding up to 1,000× its weight in water) for skin hydration and joint comfort, and AstraGin®️ for up to 70% more collagen absorption! Clean and flavorless, it disappears into coffee, smoothies, or soups—making it a perfect way to boost your collagen levels for strength, skin, and recovery. The post Meet The Secret Genius Behind UNI KEY's Collagen 4+ first appeared on Ann Louise Gittleman, PhD, CNS.

On this podcast, I cover ciprofloxacin pharmacology. Ciprofloxacin is one of the most widely recognized fluoroquinolone antibiotics and has been on the market for decades. Because of its broad utility, it often comes up in practice, but it also carries significant adverse effect concerns and boxed warnings that pharmacists and prescribers need to keep in mind. From a pharmacology standpoint, ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for bacterial DNA replication, transcription, and repair. This action gives ciprofloxacin bactericidal activity against a variety of gram-negative organisms, including E. coli, Klebsiella, Enterobacter, and Pseudomonas aeruginosa. It also has some gram-positive activity, though it is generally not the best choice for strep infections. Ciprofloxacin comes in multiple dosage forms, including oral tablets, oral suspension, and intravenous formulations, which makes it flexible across care settings. I discuss the conversion of IV and PO formulations. Pharmacokinetics are important to consider. Ciprofloxacin is primarily renally eliminated, so dose adjustments are necessary in patients with impaired kidney function. Distribution into tissues is generally good, but it has limited activity in the lungs against Streptococcus pneumoniae, which is why it is not a first-line option for community-acquired pneumonia. Adverse effects are a major concern. The fluoroquinolone class carries multiple boxed warnings. Ciprofloxacin has been associated with tendon rupture, peripheral neuropathy, CNS effects such as agitation or seizures, and exacerbation of myasthenia gravis. More recent warnings include the risk for aortic aneurysm and hypoglycemia or hyperglycemia, particularly in older adults or those with comorbidities. On top of these boxed warnings, ciprofloxacin can also prolong the QT interval and cause GI upset. Drug interactions are another big factor in practice. Ciprofloxacin is a CYP1A2 inhibitor, which can raise levels of drugs like theophylline, tizanidine, and clozapine. It also interacts with polyvalent cations such as calcium, magnesium, iron, and aluminum, which can dramatically reduce its absorption—sometimes by more than 50%. This is a common reason for treatment failure if counseling isn't provided. From a dosing perspective, ciprofloxacin is usually given 250–750 mg orally twice daily or 400 mg IV every 8–12 hours depending on the indication and severity of infection. Renal dosing adjustments are needed as kidney function declines. In summary, ciprofloxacin is a powerful antibiotic when used appropriately. It remains an option for urinary tract infections, complicated intra-abdominal infections, and some cases of hospital-acquired pneumonia, but its use must be balanced with the potential for significant adverse effects and interactions. For pharmacists, educating patients on drug interactions, counseling about boxed warnings, and ensuring correct dosing in renal impairment are some of the most valuable interventions when ciprofloxacin shows up on a medication list.

On the Feast of Our Lady of Guadalupe, Bishop Mark Seitz, Chair of the Committee on Migration, issued a statement in solidarity with migrants and invited all people of faith to pray for those forced to move from their homes. Read the statement: On Feast of Our Lady of Guadalupe, U.S. Bishops' Migration Chairman Reaffirms Church's Solidarity with Immigrants. Pope Francis also celebrated Mass for the occasion on December 12, 2022. Watch the CNS video: Pope: Guadalupe's message of hope. Learn more about the U.S. bishops' Committee on Migration: https://www.usccb.org/committees/migration While praying on the Solemnity of the Immaculate Conception of the Blessed Virgin Mary, Pope Francis broke down while speaking of the suffering in Ukraine. Watch the CNS video: Pope weeps for Ukraine. On Gaudete Sunday, Pope Francis prayed for the children of Ukraine. Watch the CNS Video Pope: May Christmas bring hope to Ukrainians.

The working document for the Synod of Bishops in October was released by the Vatican on June 20th. The document will form the basis for the discernment and discussion for the participants of the first session of the XVI Ordinary General Assembly of the Synod of Bishops to be held in October 2023 in the Vatican. Read the CNS story (https://www.usccb.org/news/2023/synod-document-asks-how-increase-unity-participation-mission-outreach). Press release (https://www.usccb.org/news/2023/usccb-welcomes-release-instrumentum-laboris-first-session-xvi-ordinary-general-assembly). The Archdiocese of St. Louis held its second annual ‘Forgive Us Our Trespasses' Maafa and prayer service to remember enslaved persons and acknowledge the archdiocese's involvement with the institution of slavery. Read the story from the St. Louis Review (https://www.archstl.org/-forgive-us-our-trespasses-maafa-and-prayer-service-remembers-enslaved-persons-8740). Learn about the USCCB Subcommittee on African American Affairs (https://www.usccb.org/committees/african-american-affairs) and the Ad Hoc Committee Against Racism (https://www.usccb.org/committees/ad-hoc-committee-against-racism). Pope Francis blessed a four-foot-tall monstrance for the U.S. National Eucharistic Congress in 2024 and spoke about how at Mass that morning he was thinking about Jesus' great gift of himself in the Eucharist, a gift that nourishes and consoles believers. Read the CNS story. Learn more about the Eucharistic Revival at (https://www.eucharisticrevival.org/) Archbishop Christophe Pierre, Apostolic Nuncio to the United States, spoke with Catholic Current about the gifts and challenges of the Catholic Church in the United States.

Released 2023.10.26 Pope Francis invited all people of faith to join him on October 27th for a day dedicated to prayer, fasting, and penance for peace and reconciliation in Israel and Gaza. Watch the CNS video: Pope: War is always a defeat. Read the letter from Cardinal Pierbattista Pizzaballa, Latin Patriarch of Jerusalem, to his entire diocese: https://www.lpj.org/posts/letter-to-the-entire-diocese.html October is Domestic Violence Awareness Month. Read the U.S. Bishops' pastoral letter, When I Call for Help: A Pastoral Response to Domestic Violence Against Women. Catholics For Family Peace Education and Research on Domestic Abuse provides education, resources, and research that help Catholics promote peace within families and to recognize and respond with compassion to domestic abuse. Visit https://www.catholicsforfamilypeace.org/ to learn more and download resources. Archbishop Timothy P. Broglio, president of the U.S. Conference of Catholic Bishops, has been participating in the assembly of the Synod of Bishops and shared with CNS some of his thoughts about the monthlong experience. Read “USCCB president talks about his synod experience.” Participants in the Synod on Synodality have approved a Letter to the People of God giving thanks for their experience, detailing the work of the past few weeks, and expressing the hope that in the coming months, everyone will be able to "concretely participate in the dynamism of missionary communion indicated by the word 'synod.'"

Released 2023.10.19 Pope Francis invited all people of faith to join him on October 27th for a day dedicated to prayer, fasting, and penance for peace and reconciliation in Israel and Gaza. Watch the CNS video: https://www.youtube.com/watch?v=XiuzrjveGv4 The bishops of the United States launched a mental health campaign on October 10th, Mental Health Day. It is a time when people from many nations are seeking to raise awareness and remove the stigma around issues concerning mental health. The bishops invite people to pray a special Novena for Mental Health. Watch : https://www.youtube.com/watch?v=pR9s8jAcqik As the Synod on Synodality continues in Rome, Catholic News Service has spoken with participants about their experiences: • WATCH: At the synod on synodality, Cardinal Tobin said a more inclusive church would better spread the Gospel: https://www.youtube.com/watch?v=pK7nKJYa88g • WATCH: Cardinal Cupich said the synod on synodality is advancing the place of women in the church: https://www.youtube.com/watch?v=MWrbp9v5tYI • WATCH: Synod leaders respond to hopes and fears about their work: https://www.youtube.com/watch?v=yvTXUSmP3Ho

Released 2023.10.06 Pope Francis told the church's 21 new cardinals, including one born in the United States, that the key to evangelizing is to "cherish in our hearts the wonder and gratitude" of having heard the Gospel message and of knowing that they, like all Christians, still must grow in faith. Read the CNS story: Creating cardinals from 16 nations, pope asks them to join church 'symphony'. Watch the CNS video ”Cardinals for a Synodal Church”, an interview with Cardinal Prevost, and an interview with Cardinal Pierre. In Pope Francis' new document on the climate crisis, he urges everyone to "move beyond the mentality of appearing to be concerned" and to have "the courage needed to produce substantial changes." Catholic Current speaks with Metropolitan Archbishop Borys Gudziak, Chair of the Domestic Justice and Human Development Committee, about environmental concerns. Learn more about the USCCB's work to promote care for our common home at www.usccb.org/environment. Read the CNS Story: Pope, in document on climate crisis, criticizes science 'deniers.' Read Laudate Deum. Catholic Current speaks with Antonia Salzano Acutis, mother of Blessed Carlo Acutis who is patron of the National Eucharistic Revival. Learn about Eucharistic Miracles of the World – an initiative led by Carlo Acutis as a teenager. Pope Francis opened the assembly of the Synod of Bishops on October 4th, 2023, with a Mass in St. Peter's Square. Read the CNS story: Pope addresses fears around synod: 'Not a political gathering'. Watch videos from CNS Rome: Pope: The church has stopped to listen and Pope: Trust God, don't fear the synod. Learn more about the synod at https://www.usccb.org/synod and visit https://www.usccb.org/newsroom for the latest news on the Synod.

Featuring an interview with Dr Sarah Sammons, including the following topics: Development of brain metastases in patients with HER2-positive and HER2-negative breast cancer (0:00) Local therapy approaches for the treatment of brain metastases (8:23) Treatment options for patients with HER2-positive breast cancer and CNS-only disease progression (16:36) Clinical presentation of leptomeningeal disease; management of functional sequelae associated with brain metastases (19:07) Investigational agents for the treatment of brain metastases in HER2-positive breast cancer (25:01) Case: A 65-year-old woman with ER-negative, HER2-positive metastatic breast cancer (mBC) develops a single 6-mm brain metastasis after 4 years of maintenance trastuzumab/pertuzumab (27:38) Screening for brain metastases; radiation necrosis as a side effect of radiation therapy (31:00) Case: A 39-year-old woman with ER-negative, HER2-positive mBC develops 7 new brain metastases 6 months into treatment with a taxane, trastuzumab and pertuzumab (34:30) CME information and select publications

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. While the development of targeted therapies has improved outcomes for many patients with EGFR-mutated NSCLC, those with rare EGFR variants often face limited treatment options, especially when the disease involves the central nervous system (CNS). A recent research paper, titled “Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib” published in Volume 16 of Oncotarget, describes a patient with NSCLC harboring two uncommon EGFR mutations—G719A and A289V—who experienced a prolonged and clinically significant response to amivantamab monotherapy, after prior treatments had failed. Full blog - https://www.oncotarget.org/2025/08/26/amivantamab-monotherapy-in-rare-egfr-mutated-advanced-nsclc/ Paper DOI - https://doi.org/10.18632/oncotarget.28730 Correspondence to - Young Kwang Chae - young.chae@northwestern.edu Video short - https://www.youtube.com/watch?v=UEiCz834a8c Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28730 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, amivantamab, monotherapy, rare EGFR mutation, NSCLC, leptomeningeal disease About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Today's guest is Boo Schexnayder. Irving “Boo” Schexnayder is a world-class coach and consultant with over 44 years of experience in track and field. Renowned for producing 26 NCAA Champions and 8 Olympic/World Championship medalists, he co-founded Schexnayder Athletic Consulting and founded the Track and Field Academy. A former LSU coach and USA Track and Field leader, Boo's expertise in biomechanics and training design extends to multiple sports, making him a sought-after mentor worldwide. It's common to think that, as time moves forward in any discipline, that discipline becomes better. What seems to define much of athletic performance and sport itself is that outputs become the priority while movement quality and literacy become watered down. On today's podcast, Boo gives wisdom into the process of comprehensive athletic development by leaning into general strength and movement training. He goes over his movement batteries, scramble circuits, training diversity, and tempo sprints. Boo also gives his take on the use of supramaximal eccentrics, covers hamstring injury prevention strategies, and discusses his sprint-float-sprint protocols, alongside a sea of further training wisdom. Today's episode is brought to you by Hammer Strength and LILA Exogen wearable resistance. Use the code “justfly25” for 25% off any Lila Exogen wearable resistance training, including the popular Exogen Calf Sleeves. For this offer, head to Lilateam.com View more podcast episodes at the podcast homepage. (https://www.just-fly-sports.com/podcast-home/) Timestamps 1:25 – The evolution of general strength since the 90s 23:12 – General strength across track and team sports 28:47 – Adding multi-directional work for linear athletes 37:18 – Managing tempo volume for higher intensity 42:50 – Polarized training over middle-ground tempo 44:14 – Using tempo for restoration, not breakdown 47:24 – Short sprints on low days to cap tissue load 48:50 – Eccentric overload within a balanced profile 57:08 – Sprinting and mobility for hamstring resilience 1:12:02 – Setting fly-float-fly zones by max velocity 1:12:52 – Coaching lessons that shaped training design Actionable Takeaways 1:25 – The evolution of general strength since the 90s Boo explains that early “general strength” meant broad, circuit-based work (med balls, hurdle mobility, bodyweight drills), and over time, coaches either overcomplicated it or lost sight of its role. What to try: Keep general strength simple—circuits that are easy to teach, scalable, and repeatable. Don't let weight room complexity replace basic movement skill. Revisit older methods (hurdle mobility, med ball throws) that build coordination without heavy stress. 28:47 – Adding multi-directional work for linear athletes Even linear sprinters benefit from “scramble” circuits and agility-oriented elements. Boo stresses that multi-directional tasks improve coordination, robustness, and adaptability. What to try: Sprinkle in agility, shuffles, and lateral bounds for athletes who train mostly linear. Build circuits that force athletes to problem-solve movement, not just run straight lines. Think “movement quality first”—variety pays off long term. 37:18 – Managing tempo volume for higher intensity Boo highlights that loading too much tempo work flattens intensity. Athletes need tempo in the right amount—enough for conditioning, not so much that it dulls speed. What to try: Keep tempo volumes moderate so athletes can still sprint fast on quality days. Use tempo as restoration or rhythm training, not just mileage. Remember: more work doesn't equal better adaptation—protect intensity. 47:24 – Short sprints on low days to cap tissue load Boo explains that short 10m sprints can safely live on “low” days—they maintain speed exposure without frying the system. What to try: Program 2–3 sets of short accelerations on low CNS days.

Lee Carroll joins The First Lady of Nutrition for a fascinating deep dive into the amazing world of functional mushrooms. Lee is a distinguished medical herbalist, innovator, speaker, educator, and mentor to health professionals worldwide. Ann Louise and Lee cover everything from mushroom coffee vs. supplements to why mushrooms deliver nutrients you won't find elsewhere. Surprising fact: humans and fungi share 30% DNA! The conversation spotlights ergothioneine—a unique antioxidant concentrated in red blood cells, the eyes, and the liver that Lee believes is poised to become the next big discovery in health circles. You'll learn where this compound is most concentrated (Golden Oyster leads the pack; Lion's Mane and Shiitake are other strong sources). In addition, you'll be privy to not only the specific amounts of these exclusive nutrients, but also why researchers are hard at work developing a test that may flag neurological risk years earlier. Lee also offers a fresh lens on why women face more autoimmunity disorders than men and how mushroom nutrients may support immune balance. These two titans of health touch on product quality, cancer-care conversations, and Lee's Top 5 mushroom picks.  Curious which mushrooms to sip, stack, or sauté? Press play—and start a smarter mushroom routine. Learn more about Lee at herbameditari.com or realmushrooms.com. The post Ergothioneine: The Most Important Nutrient You Have Never Heard Of! – Episode 201: Lee Carroll first appeared on Ann Louise Gittleman, PhD, CNS.

With more than 30 years of experience spanning global pharma, emerging biotech, and the evolving field of personalized medicine, Bracken Senior Partner Dr. David Krause has helped shape the clinical and regulatory landscape across therapeutic areas—from vaccines and anti-infectives to neuropsychiatry and oncology.As a physician, former Chief Medical Officer, and trusted development advisor, David brings a uniquely humanist and interdisciplinary lens to the science and strategy of drug development.In this episode of Fractals: Life Science Conversations, David and host Colin Miller explore:How leadership style must evolve from large pharma to small biotech—and why succession planning matters more than you think.The future of personalized medicine in CNS and oncology—and how AI, genetics, and neuroplasticity are reshaping treatment paradigms.What pharma can learn from infectious disease: why psychiatry is just now catching up to decades-old precision strategies in anti-infectives.Reflections on partnering with the FDA, lessons learned from vaccine development, and the clinical promise of psychedelics.Listen to Fractals on your favorite podcast platform, and contact Bracken to learn how our cross-functional teams can support your clinical, medical, and regulatory strategy.

Are you someone trying to manage perimenopause or menopause while ALSO dealing with frustrating chronic illness symptoms?  In this episode, I'm joined by the brilliant Dr. Jessica Drummond—clinical nutritionist, physical therapist, and board-certified health coach—who has spent over 25 years helping women navigate the tangled intersection of hormones, immune health, and chronic illness.  We dive into what to do when your perimenopause symptoms blur into post-viral syndromes, autoimmune flares, chronic fatigue, and more.  Dr. Jessica shares how to discover when there's something deeper going on—and how to uncover the real root causes of your symptoms. Plus, she offers practical, science-backed strategies to support your hormones, immune system, and energy levels, even if you've felt stuck for years.  Tune in to feel empowered AND educated on your midlife symptoms!  Jessica Drummond, DCN, CNS, PT, NBC-HWC  Dr. Jessica Drummond is the founder and CEO of The Integrative Women's Health Institute. She has 25 years of clinical experience as a licensed physical therapist, licensed clinical nutritionist, and board-certified health coach working with women who battle chronic pain, illnesses, and post-viral syndromes. Her integrative approach helps her patients overcome hormonal imbalances and chronic pain conditions. Dr. Drummond was educated at the University of Virginia, Emory University, Duke Integrative Medicine, and Maryland University of Integrative Health. IN THIS EPISODE Dr. Drummond's journey with chronic illness in perimenopause How viral illnesses like COVID impact hormones, and particularly the health of middle-aged women  How Dr. Drummond's time in Europe impacted her health Distinguishing illness symptoms from perimenopause symptoms  Non-negotiable habits for improving midlife health and energy How to prioritize yourself in perimenopause and menopause  QUOTES “85% of women in perimenopause also have other chronic illnesses; endometriosis, autoimmune disease, pain syndromes, PCOS, chronic concussions, diabetes…” “I always say this is kind of the only time in life you get to slow down for a minute. I highly suggest hiring a coach… You probably never had this opportunity to lead from your desires.”  “You're in perimenopause. You have a lot going on physiologically. You have a lot going on in your career, your parenting, but also your decisions aren't exactly your own. I feel like for me, they've always been integrated with at least my husband and my kids… so you also have to deepen your skillset of relationships, of listening, of prioritizing people's desires and needs.” RESOURCES MENTIONED Integrative Women's Health Institute Website Dr. Jessica Drummond's Free workshop for women's health and wellness professionals Integrative Women's Health Institute on Instagram  Pre-order my new book: The Perimenopause Revolution  RELATED EPISODES  591: Post Viral Syndromes, Your Immune System, and Your Hormones in Midlife with Dr. Jessica Drummond#648: This Changes Everything: The Perimenopause Revolution Every Woman Needs Now#392: How to Live with a Chronic Illness and Ways to Bring Awareness to Endometriosis and Autoimmune Conditions with Jenneh Rishe#609: Non-Negotiable Advice I Would Give My Early Perimenopausal Self

Join me for a conversation with four fantastic panelists about nuclear safety and security issues brought on by Russia's full-scale invasion of Ukraine, and more broadly on the state of nuclear security globally during this era of dramatic change.This program was made possible by the Ukrainian Platform for Contemporary China and the Center for Slavic, Eurasian, and East European Studies at the University of North Carolina Chapel Hill.Nickolas Roth is Senior Director for Nuclear Materials Security at the Nuclear Threat Initiative (NTI). Nickolas works at the intersection of arms control, risk reduction, and institutional resilience, and previously directed nuclear security work at the Stimson Center and contributed to Harvard's Project on Managing the Atom.Mariana Budjeryn is a Senior Research Associate with Managing the Atom at Harvard's Belfer Center and author of Inheriting the Bomb, a definitive study of Ukraine's post-Soviet disarmament and the limits of the Budapest Memorandum. Her scholarship grounds today's debates about guarantees, coercion, and nuclear restraint.Pan Yanliang is a Research Associate at the James Martin Center for Nonproliferation Studies (CNS). He studies the Russian and Chinese nuclear industries and the nuclear fuel cycle, and works on CNS engagement with Chinese counterparts—giving him a distinctive cross-regional vantage.Lily Wojtowicz is a Research Fellow at the Hertie School (Berlin) and a USIP–Minerva Peace & Security Scholar, whose work focuses on extended deterrence credibility, European security, and alliance adaptation under great-power rivalry.5:19 - The Gap Between Coercive Rhetoric and First-use Thresholds11:26 - The Implication of Ukraine's allies regarding weapons 17:26 - Golden Dome21:30 - China's Position on Nuclear Weapons29:25 - How Belarus Altered European Debates 31:13 - Civilian Nuclear Power 38:32 - North Korea's Support for Russia40:59 - Beijing on NATO and Asian Security43:09 - Europe's Reaction to Nuclear Risk45:44 - Nuclear Risk in the Russia-Ukraine War52:56 - Trump's Impact on Kremlin Nuclear Thinking1:01:52 - US-China Nuclear Relations1:04:49 - Ukraine's Nuclear DisarmamentSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The role of neuronal influences on cancer pathogenesis and progression is increasingly appreciated in the nervous system. Neurons have been shown to enhance the proliferation and migration of gliomas, a glial-derived tumor of the CNS, via diffusible paracrine factors or synaptic inputs onto tumor cells. In glioblastomas, a highly aggressive glioma, mostly glutamatergic inputs have been identified. While the potential for glioblastomas to receive projections from neurons of other neurotransmitter subtypes, such as from cholinergic neurons, has recently been discovered in xenotransplantation models, whether synapses can form between human cholinergic neurons and glioblastoma cells and consequences of these inputs and other non-synaptic mechanisms are still unknown.   Human induced pluripotent stem cell-based models have been emerging as a powerful platform for studying human-specific disease mechanisms. Today's guests developed a co-culture model for the study of neuron-tumor interactions by combining patient derived glioblastoma organoids and hiPSC-derived cholinergic neurons. They will discuss their recent findings and what it means for understanding and potentially treating a tumor for which there is no known cure. GuestsGuo-li Ming, MD, PhD, Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of PennsylvaniaHongjun Song, PhD, Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania Yusha Sun, Neuroscience Graduate Group, Perelman School of Medicine, University of PennsylvaniaHostJanet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner FoundationSupporting ContentPaper link:  Cholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model, Stem Cell ReportsAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Senior Marketing ManagerJack Mosher, Scientific DirectorHunter Reed, Senior Marketing Coordinator

In this episode, The First Lady of Nutrition welcomes Dr. Noel Baker, a respected functional medicine practitioner and one of the foremost protégés of Dr. Theodore Baroody, author of the groundbreaking book, The Hiatal Hernia Syndrome: The Mother of All Illnesses. Together, they explore a little-understood health issue—a hiatal hernia, which is essentially a misalignment of the stomach that can trigger a ripple effect of symptoms throughout the body. Ann Louise speaks from experience, having personally worked with Dr. Baker and experienced the healing process firsthand. A hiatal hernia is more than just a mechanical issue or a cause of common indigestion. It can be the hidden source behind a wide array of symptoms that many people—and their doctors—struggle to explain. This can include alarming symptoms that mimic heart attacks, a hijacked fight-or-flight response, disrupted vagus nerve function, trouble taking a deep breath and swallowing, plus a domino effect of stress-related imbalances throughout the body including anxiety. Listeners will also gain insight into the importance of the “alpha state,” the role of neurofeedback in restoring calm and nervous system balance, and how holistic practices like grounding, yoga, stretching—and even an unconventional method known as the “stomach egg”—can play a powerful role in the healing process. To connect with Dr. Noel Baker and his team, visit PureFunctionalMedicine.com. The post Hiatal Hernia: The Mother of All Illnesses – Episode 200: Dr. Noel Baker first appeared on Ann Louise Gittleman, PhD, CNS.

What is the role of a Clinical Nurse Specialist (CNS) in the ICU? How did Lynette LaBine, MSN, RN, CNS, CCRN leverage her CNS role to win buy-in and guide her team to become an Awake and Walking ICU? Lynette shares with us how consulting and training services opened the doors for her to fully lead the revolution in her ICU. Listen and watch Lynette's RN colleagues HERE and rehab colleagues HERE! Get your CE credit for this episode and all learning you do here!Want to bring the revolution to your ICU? Check out www.DaytonICUConsulting.com

L-Glutamine stands as one of the most powerful amino acids for optimizing gut health, muscle function, immune and brain health. It's a common solution for leaky gut, but overall can enhance the improvement of other therapies. In this episode, I'll dive into the benefits of l-glutamine, the best food sources, and effective protocols for different conditions.    ✅ Start healing with us! Learn more about our virtual clinic:https://drruscio.com/virtual-clinic/

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain, practicing community oncologists, share their key takeaways from a session on NTRK Fusion Positive Solid Malignancies, they moderated during a satellite event at ASCO 2025 in partnership with Medscape Global Oncology. Join us as we discuss: •⁠  ⁠The prevalence of NTRK fusions in various cancers and why community oncologists should be aware of them. •⁠  ⁠The importance of comprehensive next-generation sequencing (NGS) for detecting these fusions across diverse histologies. •⁠  ⁠Available treatment options, including first-generation NTRK inhibitors like larotrectinib and entrectinib, and their efficacy in improving overall and progression-free survival. •⁠  ⁠Insights into the CNS activity of these treatments and the common side effects patients may experience. •⁠  ⁠Special considerations for pediatric patients, including formulation challenges and the potential for re-challenging with NTRK inhibitors. Don't forget to check out the full accredited enduring program by Medscape Global Oncology linked below, and earn your CME credit.  https://www.medscape.org/viewarticle/1002679?src=acdmpart_onc-brothers_1002679  Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ #entrectinib #larotrectinib #repotrectinib

On episode 523 of The Nurse Keith Show nursing and healthcare career podcast, Keith interviews author, nursing educator, and researcher Dr. Ruth Wittmann-Price, PhD, RN, CNS, CNE, CNEcl, CHSE, ANEF, FAAN. In the course of their conversation, Keith and Dr. Wittmann-Price discuss the importance and impact of competency-based education in nursing. Dr. Wittmann-Price also reflects on her storied career, and her perceptions and experiences as a highly accomplished nurse academician and writer. Ruth A. Wittmann-Price, PhD, RN, CNS, CNE, CNEcl, CHSE, ANEF, FAAN, is Dean of the W. Cary Edwards School of Nursing and Health Professionals at Thomas Edison State University in Trenton, NJ. Ruth has been an obstetrical/women's health nurse for 47 years. Dr. Wittmann-Price received her AAS and BSN degrees from Felician College, Lodi, New Jersey, and her MS as a perinatal clinical nurse specialist (CNS) from Columbia University, New York, New York. She completed her PhD in nursing at Widener University, Chester, Pennsylvania, and received the Dean's Award for Excellence. Ruth developed a mid-range nursing theory, “Emancipated Decision-Making in Women's Health Care,” and has tested her theory in four research studies. International researchers are currently using her theory as the foundation for their studies. Her theory is being used by researchers at the University of Limpopo, South Africa, in their campaign, “Finding Solutions for Africa,” which helps women and children. Dr. Wittmann-Price has taught all levels of nursing students over the past 30 years and has completed international service-learning trips. She has coedited or authored 16 books, contributed many chapters, and written numerous articles. She has presented her research regionally, nationally, and internationally. Dr. Wittmann-Price was inducted into the National League for Nursing Academy of Nurse Educator Fellows in 2013 and became a fellow in the American Academy of Nursing in October 2015. This episode of the Nurse Keith Show is brought to you in collaboration with Springer Publishing, who have been delivering award-winning healthcare education and exam prep materials focused on nursing, behavioral health, and the health sciences for more than 70 years. We thank Springer Publishing for their support. Links: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fast Facts About Competency-Based Education in Nursing: How to Teach Competency Mastery Certified Nurse Educator Review, 4th Edition Springer Publishing Contact Nurse Keith about holistic career coaching to elevate your nursing and healthcare career at ⁠⁠⁠⁠⁠⁠⁠NurseKeith.com⁠⁠⁠⁠⁠⁠⁠. Keith also offers services as a motivational and keynote speaker and freelance nurse writer. You can always find Keith on⁠⁠⁠⁠⁠⁠⁠ LinkedIn⁠⁠⁠⁠⁠⁠⁠. Are you looking for a novel way to empower your career and move forward in life? Keith's wife, Shada McKenzie, is a gifted astrologer and reader of the tarot who combines ancient and modern techniques to provide valuable insights into your motivations, aspirations, and life trajectory, and she offers listeners of The Nurse Keith Show a 10% discount on their first consultation. Contact Shada at ⁠⁠⁠⁠⁠⁠⁠TheCircelandtheDot.com ⁠⁠⁠⁠⁠⁠⁠or shada@thecircleandthedot.com.

Program notes:0:40 Human Phenotype project1:43 Metabolomics2:42 25 year follow up3:43 Two control groups4:00 CBT via telehealth or online5:00 2000 people with chronic pain6:00 Completion rate for videos lower6:50 RNA analysis in cancer molecular diagnostics7:50 4.8% failure rate8:50 CNS or blood cancers primarily9:25 Middle age exposure to air pollution and later cognition10:25 Poorer processing speed earlier in life11:58 End

In this episode, we are joined by Bryce Mooney and Dr. Sam Attanasio. Bryce (@brycemooneygolf) and Sam (@drsamattanasio) are co-founders of Speed Toad @speedtoad.---Follow us: Twitter - @TournamentCode Instagram - @thetournamentcode YouTube - The Tournament Code Hosted by: Cooper Collins (@coopercollins99), Jack Bergstrom (@Jack_Bergstrom), Daniel Hamrin (@DanielHamrin)Sponsored by: https://puttviewbooks.com/---(01:30) - PuttView Books opening tee shot(02:30) - background of Speed Toad(07:18) - real effects of Speed Toad(14:09) - comparison of speed implements(19:20) - strong vs. fast(26:12) - working out and swinging fast(35:14) - overspeed training(40:13) - how they got into long drive(50:01) - measuring CNS status

Asenapine is an atypical antipsychotic that acts as an antagonist at multiple receptors, including dopamine D2 and serotonin 5-HT2A, contributing to its antipsychotic and mood-stabilizing effects. Adverse effects of asenapine include somnolence, dizziness, and extrapyramidal symptoms. Because asenapine is significantly metabolized by CYP1A2, inhibitors or inducers of these enzymes can affect its plasma concentrations. Co-administration with other CNS depressants may increase the risk of sedation and impaired cognitive or motor function. Asenapine can prolong the QT interval, so caution is advised when used with other medications that affect cardiac conduction.

The First Lady of Nutrition spotlights environmental toxins expert Lara Adler. Adler is a globally recognized Environmental Health Educator who has trained thousands of practitioners to identify and address hidden toxic exposures impacting chronic health. Together, Ann Louise and Lara explore the unexpected ways chemicals in our everyday environment are sabotaging our health—and our waistlines. From hidden toxins in cookware, food packaging, and personal care products to unexpected offenders like candles, perfumes, and even your mattress, no topic is off-limits. You'll learn why the kitchen is frequently a chemical hotspot in the home, how “obesogens” may be fueling weight gain without you even consuming extra calories, and what to watch for in your bedroom, bathroom, and beyond. They even dive into the potential risks of candles, incense, tattoos, and whether essential oils are truly safe. Most importantly, Lara shares practical, doable swaps to reduce your toxic load without turning your life upside down.  Visit laraadler.com to learn more. The post How Common Household Chemicals are Disrupting Hormones, Weight & Wellbeing – Episode 199: Lara Adler first appeared on Ann Louise Gittleman, PhD, CNS.

In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the July 2025 Emergency Medicine Practice article, Emergency Department Management of Status Epilepticus in Pediatric PatientsIntroductionWelcome and brief overview of the episodePromotion of EB Medicine's $1 for 7-day trial offerWhy Pediatric Status Epilepticus MattersSeizures make up ~1% of ED visits and ~3% of EMS callsHigh-risk and high-stakes condition requiring rapid actionStatus epilepticus now defined as ≥5 minutes of seizure activityILAE's T1 and T2 timelines help define when to treat and when damage beginsCommon CausesTop contributors:Fever/infectionStructural CNS abnormalitiesToxic ingestionsGenetic/metabolic disordersAdditional factors by age:Infants: febrile seizures, chromosomal issues, traumaSchool-age: autoimmune disordersAdolescents: eclampsia, hypertension, functional disordersAlways consider non-accidental traumaPrehospital CareIM midazolam is effective and recommended (RAMPART trial)Other options: intranasal, rectal, or IV benzodiazepinesEarly benzodiazepine administration improves outcomesImportance of airway support, glucose check, and EMS flexibilityParent-administered home meds (e.g. rectal diazepam) can be helpfulED Evaluation and Initial ManagementPrioritize ABCs: Airway, Breathing, Circulation, ConsciousnessUse end-tidal CO₂ to monitor ventilation if availablePoint-of-care glucose is essentialLabs: CMP, Mg, Phos, lactate, drug levels, pregnancy test (when indicated)Imaging: Head CT if concern for trauma, shunt malfunction, or focal signsCase examples highlight pitfalls and diagnostic delaysFirst-Line TreatmentBenzodiazepines remain the cornerstoneLorazepam preferred IV agent (0.1 mg/kg)Midazolam preferred if no IV access (IN, IM, or IO)Diazepam is also effective, especially rectallyBe mindful of respiratory depression and the need for airway controlSecond- and Third-Line TherapiesBased on ESETT trial:Levetiracetam, fosphenytoin, and valproate have similar efficacyLevetiracetam favored for safety and ease of useFosphenytoin may be avoided in trauma or toxicityValproate not recommended in mitochondrial diseasePhenobarbital reserved for refractory cases onlyRefractory Status EpilepticusDefinition: persistent seizures despite first- and second-line agentsRequires sedation and likely intubationInfusion options:Midazolam (preferred for flexibility)Propofol (short-term use only due to risk of infusion syndrome)Pentobarbital (rare, ICU-level care)Need for continuous EEG to assess seizure activitySpecial ScenariosNeonates:Watch for subtle signs (lip smacking, bicycling, tongue thrusting)Broad differential includes asphyxia, infection, metabolic errorsFebrile Status Epilepticus:Higher risk of CNS infections, especially if unvaccinatedConsider lumbar puncture if indicatedElectrolyte/Metabolic Triggers:Treat hypoglycemia, hyponatremia, and hypocalcemia directlyUse 3% saline or dextrose as appropriateDisposition and Discharge ConsiderationsMany children will require ICU-level careSome known epilepsy patients may go home if back to baselineEnsure rescue medications are up to date (rectal/intranasal benzos)Consider “clonazepam bridge” for short-term seizure preventionCollaborate with neurology for medication adjustment and follow-upFinal ThoughtsKeep treatment tables and dosing references accessibleEarly, aggressive treatment can prevent long-term harmEpisode closes with gratitude to article authors and a reminder to visit EBMedicine.netEmergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

Dr. Pallawi Torka of Memorial Sloan Kettering Cancer Center joins to share highlights from ASCO and EHA 2025 on the evolving landscape of B-cell lymphomas, including Hodgkin lymphoma, diffuse large B-cell lymphoma (DLBCL), and follicular lymphoma. She offers in-depth insights on the STARGLO study and its recent ODAC review, the POLARGO trial, a rare T-cell leukemia (T-LGL) study, and new data supporting nivolumab-AVD in frontline Hodgkin lymphoma. Additional discussion includes the inMIND trial for follicular lymphoma, the growing role of ctDNA in managing DLBCL, advances in CAR-T cell therapy for CNS lymphoma, and how she is adapting treatment strategies based on favorable vs. unfavorable disease features. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: 7 natural ways to crush chronic inflammation and pain. (1:32) The benefits of regular napping. (21:50) Overactive bladder syndrome. (28:25) Green tea consumption = higher testosterone. (35:48) If you were stranded on an island, would you rather be by yourself or with your worst enemy? (36:40) Adam's Best Buy fiasco. (43:11) Sodium, low-carb diets, and performance. (47:42) Previewing Sal's upcoming YouTube series. (49:54) Mind Pump is looking for trainers. Apply today! (53:24) #ListenerLive question #1 – Is MAPS Muscle Mommy the right program for me being 14 months post-partum? If I'm only lifting 3 days a week and not looking to do extra work from home, are the trigger sessions necessary? (54:10) #ListenerLive question #2 – How can someone in a cut still feel confident about their progress when the scale isn't moving? (1:10:22) #ListenerLive question #3 – How would you go about actively inspiring reform and rebuilding a community for people who are so set in their ways? (1:18:57) #ListenerLive question #4 – Is there anything I can do to build a more resilient CNS or recover better so I don't need those rest weeks as often? (1:36:20) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit NED for an exclusive offer for Mind Pump listeners! ** Code MINDPUMP at checkout for 20% off ** Get your free Sample Pack with any “drink mix” purchase! Find your favorite LMNT flavor, or share it with a friend. Try LMNT risk-free. If you don't like it, give it away to a salty friend and we'll give you your money back, no questions asked! Visit DrinkLMNT.com/MindPump June Special: Shredded Summer Bundle or Bikini Bundle 50% off! ** Code JUNE50 at checkout ** The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials Importance of maintaining a low omega–6/omega–3 ratio for reducing inflammation Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 20% off** Regular Napping Linked to Increased Brain Size Mirabegron in the Treatment of Overactive Bladder Why Green Tea Could Be Your New Secret Weapon for More Testosterone TableTopics Dinner Party Question Card Game - 135 Entertaining Conversation Starter Cards for Dinner Table with Adult Friends, Getting to Know You Game. Mind Pump Personal Training – Apply today! Visit Butcher Box for this month's exclusive Mind Pump offer!  ** Available for a limited time, a curated box pre-filled with Mind Pump's favorite cuts — no guesswork! ButcherBox members who sign up through Mind Pump will receive: $20 OFF their first box, Free chicken breast, ground beef, OR salmon in every box for a whole year! ** 10 Ways To Rebuild MUSCLE & Train SAFELY After Having A Baby | Mind Pump 1882 Mind Pump #2320: Throw Away the Scale! Mind Pump #2420: Get Energized: The Real Reasons You're Always Tired & Lazy! Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Jay Campbell (@jaycampbell333) Instagram Dr. Stephen Cabral (@stephencabral) Instagram  

Fluphenazine is a high-potency typical antipsychotic that primarily acts as a dopamine D2 receptor antagonist in the mesolimbic pathway, reducing positive symptoms of schizophrenia. Extrapyramidal symptoms (EPS), such as dystonia, akathisia, and parkinsonism, are common due to potent D2 blockade in the nigrostriatal pathway. Neuroleptic malignant syndrome (NMS), though rare, is a life-threatening adverse effect characterized by rigidity, hyperthermia, altered mental status, and autonomic instability. CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) can increase fluphenazine plasma concentrations, potentially raising the risk of toxicity and side effects. Concomitant use of fluphenazine with CNS depressants (e.g., alcohol, benzodiazepines) can enhance sedation and respiratory depression.