Podcasts about CNS

Episode 210: Heat Stroke BasicsWritten by Jacob Dunn, MS4, American University of the Caribbean. Edits and comments by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice. Definition:Heat stroke represents the most severe form of heat-related illness, characterized by a core body temperature exceeding 40°C (104°F) accompanied by central nervous system (CNS) dysfunction. Arreaza: Key element is the body temperature and altered mental status. Jacob: This life-threatening condition arises from the body's failure to dissipate heat effectively, often in the context of excessive environmental heat load or strenuous physical activity. Arreaza: You mentioned, it is a spectrum. What is the difference between heat exhaustion and heat stroke? Jacob: Unlike milder heat illnesses such as heat exhaustion, heat stroke involves multisystem organ dysfunction driven by direct thermal injury, systemic inflammation, and cytokine release. You can think of it as the body's thermostat breaking under extreme stress — leading to rapid, cascading failures if not addressed immediately. Arreaza: Tell us what you found out about the pathophysiology of heat stroke?Jacob: Pathophysiology: Under normal conditions, the body keeps its core temperature tightly controlled through sweating, vasodilation of skin blood vessels, and behavioral responses like seeking shade or drinking water. But in extreme heat or prolonged exertion, those mechanisms get overwhelmed.Once core temperature rises above about 40°C (104°F), the hypothalamus—the brain's thermostat—can't keep up. The body shifts from controlled thermoregulation to uncontrolled, passive heating. Heat stroke isn't just someone getting too hot—it's a full-blown failure of the body's heat-regulating system. Arreaza: So, it's interesting. the cell functions get affected at this point, several dangerous processes start happening at the same time.Jacob: Yes: Cellular Heat InjuryHigh temperatures disrupt proteins, enzymes, and cell membranes. Mitochondria start to fail, ATP production drops, and cells become leaky. This leads to direct tissue injury in vital organs like the brain, liver, kidneys, and heart.Arreaza: Yikes. Cytokines play a big role in the pathophysiology of heat stroke too. Jacob: Systemic Inflammatory ResponseHeat damages the gut barrier, allowing endotoxins to enter the bloodstream. This triggers a massive cytokine release—similar to sepsis. The result is widespread inflammation, endothelial injury, and microvascular collapse.Arreaza: What other systems are affected?Coagulation AbnormalitiesEndothelial damage activates the clotting cascade. Patients may develop a DIC-like picture: microthrombi forming in some areas while clotting factors get consumed in others. This contributes to organ dysfunction and bleeding.Circulatory CollapseAs the body shunts blood to the skin for cooling, perfusion to vital organs drops. Combine that with dehydration from sweating and fluid loss, and you get hypotension, decreased cardiac output, and worsening ischemia.Arreaza: And one of the key features is neurologic dysfunction.Jacob: Neurologic DysfunctionThe brain is extremely sensitive to heat. Encephalopathy, confusion, seizures, and coma occur because neurons malfunction at high temperatures. This is why altered mental status is the hallmark of true heat stroke.Arreaza: Cell injury, inflammation, coagulopathy, circulatory collapse and neurologic dysfunction. Jacob: Ultimately, heat stroke is a multisystem catastrophic event—a combination of thermal injury, inflammatory storm, coagulopathy, and circulatory collapse. Without rapid cooling and aggressive supportive care, these processes spiral into irreversible organ failure.Background and Types:Arreaza: Heat stroke is part of a spectrum of heat-related disorders—it is a true medical emergency. Mortality rate reaches 30%, even with optimal treatment. This mortality correlates directly with the duration of core hyperthermia. I'm reminded of the first time I heard about heat stroke in a baby who was left inside a car in the summer 2005. Jacob: There are two primary types: -nonexertional (classic) heat stroke, which develops insidiously over days and predominantly affects vulnerable populations like children, the elderly, and those with chronic illnesses during heat waves; -exertional heat stroke, which strikes rapidly in young, otherwise healthy individuals, often during intense exercise in hot, humid conditions. Arreaza: In our community, farm workers are especially at risk of heat stroke, but any person living in the Central Valley is basically at risk.Jacob: Risk factors amplify vulnerability across both types, including dehydration, cardiovascular disease, medications that impair sweating (e.g., anticholinergics), and acclimatization deficits. Notably, anhidrosis (lack of sweating) is common but not required for diagnosis. Hot, dry skin can signal the shift from heat exhaustion to stroke. Arreaza: What other conditions look like heat stroke?Differential Diagnosis:Jacob: Presenting with altered mental status and hyperthermia, heat stroke demands a broad differential to avoid missing mimics. -Environmental: heat exhaustion, syncope, or cramps. -Infectious etiologies like sepsis or meningitis must be ruled out. -Endocrine emergencies such as thyroid storm, pheochromocytoma, or diabetic ketoacidosis (DKA) can overlap. -Neurologic insults include cerebrovascular accident (CVA), hypothalamic lesions (bleeding or infarct), or status epilepticus. -Toxicologic culprits are plentiful—sympathomimetic or anticholinergic toxidromes, salicylate poisoning, serotonin syndrome, malignant hyperthermia, neuroleptic malignant syndrome (NMS), or even alcohol/benzodiazepine withdrawal. When it comes to differentials, it is always best to cast a wide net and think about what we could be missing if this is not heat stroke. Arreaza: Let's say we have a patient with hyperthermia and we have to assess him in the ER. What should we do to diagnose it?Jacob: Workup:Diagnosis is primarily clinical, hinging on documented hyperthermia (>40°C) plus CNS changes (e.g., confusion, delirium, seizures, coma) in a hot environment. Arreaza: No single lab confirms it, but targeted testing allows us to detect complications and rule out alternative diagnosis. Jacob: -Start with ECG to assess for dysrhythmias or ischemic changes (sinus tachycardia is classic; ST depressions or T-wave inversions may hint at myocardial strain). -Labs include complete blood count (CBC), comprehensive metabolic panel (electrolytes, renal function, liver enzymes), glucose, arterial blood gas, lactate (elevated in shock), coagulation studies (for disseminated intravascular coagulation, or DIC), creatine kinase (CK) and myoglobin (for rhabdomyolysis), and urinalysis. Toxicology screen if history suggests. Arreaza: I can imagine doing all this while trying to cool down the patient. What about imaging?-Imaging: chest X-ray for pulmonary issues, non-contrast head CT if neurologic concerns suggest edema or bleed (consider lumbar puncture if infection suspected). It is important to note that continuous core temperature monitoring—via rectal, esophageal, or bladder probe—is essential, not just peripheral skin checks. Arreaza: TreatmentManagement:Time is tissue here—initiate cooling en route, if possible, as delays skyrocket morbidity. ABCs first: secure airway (intubate if needed, favoring rocuronium over succinylcholine to avoid hyperkalemia risk), support breathing, and stabilize circulation. -Remove the patient from the heat source, strip clothing, and launch aggressive cooling to target 38-39°C (102-102°F) before halting to prevent rebound hypothermia. -For exertional cases, ice-water immersion reigns supreme—it's the fastest method, with immersion in cold water resulting in near-100% survival if started within 30 minutes. -Nonexertional benefits from evaporative cooling: mist with tepid water (15-25°C) plus fans for convective airflow. -Adjuncts include ice packs to neck, axillae, and groin; -room-temperature IV fluids (avoid cold initially to prevent shivering); -refractory cases, invasive options like peritoneal lavage, endovascular cooling catheters, or even ECMO. -Fluid resuscitation with lactated Ringer's or normal saline (250-500 mL boluses) protects kidneys and counters rhabdomyolysis—aim for urine output of 2-3 mL/kg/hour. Arreaza: What about medications?Jacob: Benzodiazepines (e.g., lorazepam) control agitation, seizures, or shivering; propofol or fentanyl if intubated. Avoid antipyretics like acetaminophen. For intubation, etomidate or ketamine as induction agents. Hypotension often resolves with cooling and fluids; if not, use dopamine or dobutamine over norepinephrine to avoid vasoconstriction. Jacob: What IV fluid is recommended/best for patients with heat stroke?Both lactated Ringer's solution and normal saline are recommended as initial IV fluids for rehydration, but balanced crystalloids such as LR are increasingly favored due to their lower risk of hyperchloremic metabolic acidosis and AKI. However, direct evidence comparing the two specifically in the setting of heat stroke is limited. Arreaza: Are cold IV fluids better/preferred over room temperature fluids?Cold IV fluids are recommended as an adjunctive therapy to help lower core temperature in heat stroke, but they should not delay or replace primary cooling methods such as cold-water immersion. Cold IV fluids can decrease core temperature more rapidly than room temperature fluids. For example, 30mL/kg bolus of chilled isotonic fluids at 4 degrees Celsius over 30 minutes can decrease core temperature by about 1 degree Celsius, compared to 0.5 degree Celsius with room temperature fluids. Arreaza: Getting cold IV sounds uncomfortable but necessary for those patients. Our favorite topic.Screening and Prevention:-Heat stroke prevention focuses on public health and individual awareness rather than routine testing. -High-risk groups—elderly, children, athletes, laborers, or those on impairing meds—should acclimatize gradually (7-14 days), hydrate preemptively (electrolyte solutions over plain water), and monitor temperature in exertional settings. -Communities during heat waves need cooling centers and alerts. -For clinicians, educate patients with CVD or obesity about early signs like dizziness or nausea. -No formal "screening" exists, but vigilance in EDs during summer surges saves lives. -Arreaza: I think awareness is a key element in prevention, so education of the public through traditional media like TV, and even social media can contribute to the prevention of this catastrophic condition.Jacob: Ya so heat stroke is something that should be on every physician's radar in the central valley especially in the summer time given the hot temperatures. Rapid recognition is key. Arreaza: Thanks, Jacob for this topic, and until next time, this is Dr. Arreaza, signing off.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! References:Gaudio FG, Grissom CK. Cooling Methods in Heat Stroke. J Emerg Med. 2016 Apr;50(4):607-16. doi: 10.1016/j.jemermed.2015.09.014. Epub 2015 Oct 31. PMID: 26525947. https://pubmed.ncbi.nlm.nih.gov/26525947/.Platt, M. A., & LoVecchio, F. (n.d.). Nonexertional classic heat stroke in adults. In UpToDate. Retrieved September 7, 2025, from https://www.uptodate.com/contents/nonexertional-classic-heat-stroke-in-adults. (Key addition: Emphasizes insidious onset in at-risk populations and the role of urban heat islands in exacerbating classic cases.) Heat Stroke. WikEM. Retrieved December 3, 2025, from https://wikem.org/wiki/Heat_stroke. (Key additions: Details on cooling rates for immersion therapy, confirmation that anhidrosis is not diagnostic, and fluid titration to urine output for rhabdomyolysis prevention.)Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/. 

Title: Wellness Podcast: Healing Ourselves - Neurosurgeons as Whole Person Health Advocates Guest: Ann Stroink Hosts: Brian Gantwerker and Lara Massie In this episode of the CNS wellness podcast, we speak to a career neurosurgeon who has transitioned into a new role as a whole person health advocate and practitioner. Dr. Ann Stroink enlightens us with a unique and fresh perspective that's important both for us as Physicians and as people ourselves. We get front row seat in making tangible changes that can help our patients in their recovery from surgery and simultaneously positively affect our own health.  We hope you join us in the conversation.  

We love to hear from our listeners. Send us a message.In episode 119 of Cell & Gene The Podcast, Host Erin Harris talks to Dr. Norman Putzki, Global Head Clinical Development, Novartis, about the FDA approval of Itvisma, now the only gene replacement therapy approved for children, adolescents, and adults with spinal muscular atrophy (SMA). Dr. Putzki walks us through the six-year development journey behind the STEER and STRENGTH Phase 3 programs. And we explore what the expanded age-range label means for patients who were previously left behind, why intrathecal, fixed-dose AAV delivery represents a pivotal advance for safety, efficacy, and scalability. He details how the Itvisma program is informing Novartis' broader gene therapy strategy across neuromuscular and CNS diseases, and more.Subscribe to the podcast!Apple | Spotify | YouTube Visit my website: Cell & Gene Connect with me on LinkedIn

Your off-season choices today determine your race day results tomorrow.Most runners get the transition season completely wrong—they either hammer through on their way to burnout or disappear entirely and spend January rebuilding from scratch. In this episode, we break down what actually works for year-over-year improvement.We cover why taking zero time off after race season is a recipe for injury and plateau, the science of post-race recovery (CNS fatigue, hormonal reset, glycogen restoration), and why detraining fears are almost always overblown. We play Hot or Not with common off-season approaches so you know what to keep and what to ditch, discuss frequency goals vs. volume goals and why the switch changes everything, and talk about building accountability systems that don't rely on motivation.The bottom line: rest is part of training—make this a core belief in 2026. You can cut volume in half for 4-6 weeks and only lose 5-10% fitness. Simpler plans are more likely to be followed. And your January determines your July.Before spring hits, take 2-4 weeks of intentional rest after your last A-race, complete a full season assessment to identify 2-3 specific pain points, set frequency goals for transition season, build at least one accountability system into your training, and schedule monthly low-key events to stay engaged.Connect with us:Email: microcosm.coaching@gmail.comWebsite: microcosm-coaching.com

Drs. Yu and Herzberg discuss recent developments in HER2- and EGFR-targeted therapies for lung cancer, focusing on clinical trial results at ESMO 2025. Key highlights include promising response rates, toxicity profiles, and the potential for these targeted therapies to treat patients with specific genetic mutations, particularly those with CNS metastases.

Dr Jeremy Clark unpacks why leukodystrophy caused by biallelic HMBS variants does not respond to liver transplantation or hepatically targeted therapies, pointing instead to CNS-driven porphyrin toxicity and a need for entirely new management approaches. Liver Transplantation and Other Hepatically Directed Therapies Do Not Change the Biochemical Phenotype nor Halt Progression of Leukodystrophy due to Biallelic HMBS Variants: A Case Report Jeremy Clark, et al https://doi.org/10.1002/jmd2.70056

John and Dom introduce guest Brad Nawa (Alamar Biosciences) to explain the NULISA™ platform, an ultra-sensitive platform for protein quantitation that aims to outperform earlier “ultra-sensitive” tools that often didn't translate well in practice. Brad notes the platform is still antibody/content-driven, but differentiates itself by reducing background through a dual-capture purification step and a nucleic-acid barcode/ligation readout, enabling scalable multiplexing (currently ~256-plex, with room to expand). They emphasize the fully automated ARGO™ HT system as a key advantage for minimizing operator variability and supporting strong instrument-to-instrument and lot-to-lot reproducibility. The discussion covers applications including biomarker discovery/monitoring, patient stratification, and PK/PD - especially when sample volume is limited or sensitivity is critical - and use across many matrices (plasma/serum/CSF, tissue lysates, vitreous humor, and dried blood/plasma spots with high recovery reported for most targets). They close by framing the future around building robust datasets for AI/meta-analysis, expanding therapeutic content (notably CNS/neurodegeneration, immunology, and cardiometabolic), and improving cloud software for pathway-level interpretation.“The Weekly Bioanalysis” is a podcast dedicated to discussing bioanalytical news, tools and services related to the pharmaceutical, biopharmaceutical and biomarker industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Senior Scientific Advisors as they chat over coffee and discuss what they've learned about the bioanalytical world the past couple of weeks. “The Weekly Bioanalysis” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries. 

Wes Youngberg, DrPH, MPH, CNS, FACLM, continues detailing the comprehensive ten-step protocol for testing and reversing Alzheimer's disease. Learn advanced strategies and targeted interventions to protect cognitive health and improve brain function. #AlzheimersReversal #BrainHealth #MemoryCare

why this is valuable for everyone if they exercise or notbeing merging knowing and doingRoot → Align → Open → DriveDhanurveda: the Spanda phasescalm means organizeddr shen no such thing as chakraslearning how to move.sumo [horse stance] then motion under weight is the true test.. can not fake itgeometry in motion under weight… multiple moves too soon put focus on externaldr wang on youtube.. question if it is even real?long routines can be external training with minimal internal focuscultivating CNS. fascia, muscle integration.  proper exercise is not about the muscle but indirectlyCNS gives permission, Fascia [silk web] regulates the flow, muscle follows.Dhanurveda: power arising when geometry is recognized as safelife in the physical is the art of archerysilk reeling web… fasciafascia snags… not muscle knotsreading.. i remember Mantak Chia books showed spiralsmicrocosmic orbit as overlaydiscover it… do not overlay ithara “location"… pressure… place where fascia planes meetall movement come through the hara—center of fascia planesdan tien… first chakrathe doors are not the roomdoors are just valuable gateways but forgotten once in the roomat age 75 realizing i needed another 20 years to finish Mt Somastarted working out watching diet lead to sumo. watched and listened to western dead lifters [Natasha Auguy, Stefi Cohen], realized mapping to internal arts while clarifying them via another angle [reality]. Support the show

This week we're coming off a solid crew Christmas party with the Keto Savage crew—good food, good company, and a surprisingly competitive keto dessert showdown. We talk through some of the highlights, including a few creative “brick-based” desserts, cast-iron chaos baking, and why consistency always beats perfection, even when you're experimenting in the kitchen.We also get into holiday logistics around the office—skeleton crew operations, shipping timelines, inventory drops, and how we're handling fulfillment with people traveling. If you're placing orders this week, everything will go out as soon as we're back in the normal workflow, so appreciate everyone's patience around the holidays.On the training side, we break down how things are progressing right now—strength is climbing, bodyweight is stable, and offseason macros are doing their job. We talk deloads, CNS fatigue, training while traveling, and why listening to objective performance markers matters more than just “feeling tired.” There's also some discussion around trail running, endurance work, and getting prepped for upcoming challenges like the mud run.Nutrition-wise, we dig into fasting protocols, including multi-day fasts, water vs. dry fasting, and why neither of us uses fasting as a fat-loss tool. For us, it's about cognitive reset, gut health, and long-term sustainability—never starvation. We also talk through how higher intake, consistent training, and repeatable food choices remove decision fatigue and make progress inevitable.We wrap things up with a broader mindset conversation heading into the new year—why we don't really believe in “resolutions,” why progress is the most motivating force there is, and how committing to small daily actions compounds over time. Whether it's training, nutrition, business, or relationships, you're either moving forward or falling behind—so focus on something you can execute every single day and build from there.Merry Christmas, happy holidays, and we'll see you heading into World Carnivore Month and the start of another strong year.Greg Mahler is also a lifetime natural bodybuilder, and can be followed on Instagramhttps://www.instagram.com/ketogreg80/Register For My FREE Masterclass: https://www.ketobodybuilding.com/registration-2Get Keto Brick: https://www.ketobrick.com/Subscribe to the podcast: https://open.spotify.com/show/42cjJssghqD01bdWBxRYEg?si=1XYKmPXmR4eKw2O9gGCEuQ

Listen Online: About this episode: The First Lady of Nutrition welcomes Tamera Campbell, a dear friend and revered acquaintance. Tamera is the founder of E3LIVE, and the conversation begins in a remote mountain lake in southern Oregon—one of the only places in the world where a rare, nutrient-dense blue-green algae can be harvested sustainably. In this episode, Tamera shares the story behind E3LIVE and explains what makes its signature ingredient, Aphanizomenon flos-aquae (AFA), so special—from its exceptional purity and rigorous testing to its unique ability to support brain function, mental clarity, immune health, digestion, and cellular nourishment. Ann Louise and Tamera also explore why professional and recreational athletes have gravitated toward AFA for its natural anti-inflammatory properties, recovery support, and sustained energy. They break down the science behind blue-green algae's rare blue pigment—sometimes called the “molecule of love” for how it interacts with the brain—and explain why it's gentle enough for children and infants, yet effective for those with high physical demands.   Learn more about E3Live at https://e3live.com/?bg_ref=rZg8FMANhuThe post The Extraordinary Power of Blue-Green Algae first appeared on Ann Louise Gittleman, PhD, CNS.

In this episode of The Nurse Practitioner Podcast, Julia Rogers, DNP, APRN, CNS, FNP-BC, FAANP, FAAN and Michelle A. Nelson, PhD, MBA, APRN, FNP-BC, FAANP, FAAN, FNAP, FADLN discuss advocacy.

Kendall Mackintosh, MS, CNS, LDN, INHC is a clinically trained nutrition expert who blends evidence-based science with integrative health coaching to address root causes—not just symptoms. With a focus on metabolic health and sustainable lifestyle change, Kendall helps clients turn complex nutrition science into practical, life-changing results. In this episode, Dr. Tro, Dr. Brian, and Kendall talk about… (00:00) Intro (02:19) How Kendall became involved in the MAHA movement (15:45) Medical misinformation and getting de platformed (18:22) The low-hanging fruit you can take advantage of to help protect your family's health (23:26) Glyphosates, heavy metals, micro plastics, mold, and parasites (32:36) Testing for mold, heavy metals, and other toxins (34:29) Parasite tests (39:11) Fasting and gut health (43:57) The vaccine religion (50:16) Moms Across America (58:25) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Kendall Mackintosh: Website: https://kendallmackintosh.com IG: https://www.instagram.com/kendall.mackintosh/ X: https://x.com/healthy_kendall Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/ 

Ketamine is a dissociative anesthetic that provides powerful analgesia while preserving spontaneous ventilation, airway reflexes, and sympathetic tone, which makes it especially valuable in trauma, bronchospasm, difficult airways, and in patients with high opioid tolerance. As a phencyclidine derivative with a chiral center, it exists as two enantiomers, with S-ketamine roughly twice as potent as R-ketamine and associated with fewer unpleasant emergence reactions, while its pKa and balanced water–lipid solubility allow rapid CNS penetration and redistribution-limited offset. Its multimodal mechanism centers on noncompetitive NMDA antagonism but also includes opioid receptor modulation, catecholamine reuptake inhibition, AMPA receptor effects, ion channel blockade, muscarinic antagonism, and anti-inflammatory actions, all of which underpin clinical dosing strategies for induction, maintenance, procedural sedation, and analgesic infusions as well as key considerations around emergence delirium, secretions, cardiovascular status, and ICP.Want to learn more? Grab our Cardiac Pharm Course --> [HERE]⚛️ CONNECT:

In this live Red Delta Project Q&A, Matt digs into a big 2025 lesson that came out of writing Beautiful Strength: diet and exercise can absolutely influence how you look, feel, and perform—but if you chase a goal blindly, your habits can backfire and give you the opposite result. Using a “hit the target” analogy (and a few colorful side stories), he explains why your results come from achieving the right objective, not from grinding harder, eating “cleaner,” or following a program with blind loyalty.From there, the episode turns into a rapid-fire Q&A on practical training topics: whether you need to go to failure with Double Tap Training, how to balance intensity with reps and rest, walking as conditioning, yoga vs direct flexibility work, knee stability, building arms with compounds, grip changes, circuit training for endurance, and more. There's also a surprisingly thoughtful section on accepting hair loss—framed through confidence, control, and reframing the story you tell yourself.

Send us a textA small structural “bump” on a molecule might be the big breakthrough EPM care has been waiting for. We sit down with researcher and clinician Izabela de Assis Rocha to unpack how bumped kinase inhibitors exploit a tiny difference between parasite and mammalian kinases to hit Sarcocystis neurona where it hurts—motility, invasion, and replication—while sparing the horse. It's a molecular strategy with practical promise, and the conversation bridges the stall, the lab, and the future of equine neurology.We break down the science behind CDPK1, the gatekeeper residue that drives selectivity, and why unique parasite structures like the apical complex and apicoplast open new therapeutic lanes. Then we move into what really matters for care: pharmacokinetics and clinical fit. BKI-1708 shows strong systemic distribution that positions it as a prophylactic candidate, while early data on BKI-1553 suggests better CNS penetration and a path toward active EPM treatment. Isabella explains how EPM's dead-end host biology may lower the risk of widespread resistance, a rare bright spot in the antiparasitic landscape.Clinical trials are the hard part. With no robust experimental infection model and fewer than 1% of exposed horses developing disease, enrolling enough cases takes patience and teamwork. We talk about building pragmatic, clinician-led studies, harmonizing diagnostics and neurologic scoring, and tracking relapse to find outcomes that matter to horses and owners. The One Health angle also shines through: BKIs show activity against equine piroplasmosis and have potential roles in toxoplasmosis and cryptosporidiosis, linking equine research to human and livestock health.If you care about evidence-based equine neurology, new antiparasitic strategies, and turning elegant biochemistry into barn-side change, this is your roadmap. Subscribe, share with a colleague who manages EPM cases, and leave a review to help more veterinarians find the show. What question would you ask about bringing BKIs into practice?AJVR article: https://doi.org/10.2460/ajvr.25.07.0270INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

Just finished a hard training block (like the Rapha Festive 500) and feel completely wrecked? In this episode, Coach Jen breaks down how cyclists should recover after intense training blocks so you can absorb your fitness gains instead of burning out. Whether you're a gravel cyclist, mountain biker, or endurance athlete stacking big winter miles, this episode covers science-backed recovery strategies including sleep, nutrition, nervous system regulation, parasympathetic breathwork, mobility, and how to safely return to training intensity. Learn how to calm your central nervous system, speed up recovery, prevent injury, and maintain motivation after demanding bike challenges, without losing the fitness you worked so hard to build. In this episode, you'll learn: Why recovery is where cycling fitness actually improves How the Rapha Festive 500 (and similar challenges) stress the nervous system Signs you need recovery vs. more training How parasympathetic breathwork accelerates recovery Simple breathing drills to calm the CNS after hard rides What to eat after a heavy training block How to structure recovery days without losing fitness When to safely reintroduce intensity Why mental recovery matters just as much as physical recovery Check out these other relevant episodes: 234. How to Not Hate Your Trainer: Making Indoor Rides Suck 80% Less 226. Off-Season Strength Training for Cyclists: Build Your Best Season Yet 221. How to Develop Durability on the Bike Do you have nutrition and fitness goals? I’m your coach!  If you’re ready to finally make some sustainable progress, feel strong and powerful on every climb uphill, feel less pain, perform better, or lose a few extra pounds, then apply to work with me by clicking here. I work with people just like you, and you’ll see results a helluva lot faster than on your own. #ShredStrong: Our Winter Cycle Starts on Monday, January 5, 2026! #ShredStrong is my year-round strength training program for mountain bikers and gravel cyclists. You can join any time you want, but we’re starting the main Winter cycle in January! Learn more about the program and sign-up HERE!  Keywords: cycling recovery strategies, how to recover after hard cycling training, Rapha Festive 500 recovery, cyclist nervous system recovery, parasympathetic breathwork for athletes, winter cycling recovery, endurance cycling recovery tips, gravel cycling recovery, mountain bike recovery, CNS fatigue cycling

Topics • Anaheim weekend fatigue and the familiar Day 3 emotional swing • HYROX recovery zones and why unmanned spaces are a problem • Judging consistency, warnings vs. penalties, and the "foot on the line" issue • Wall balls: presentation vs. practicality, no-reps, and the box decision • Shoes off for wall balls and grip issues with newer balls • CrossFit criticism of HYROX and why it misses the point • Greyson Kilgore's medical incident and how the community responded • Recognizing danger signs vs. normal race pain • CNS load, cumulative racing, and when to pull the plug • Community, identity, and why HYROX hits differently • Anaheim course layout and spectator experience • Melbourne broadcast notes and on-air shoe marketing • Elite 15 qualification changes: what's confirmed vs. rumored • Doubles inclusion and January timing for details Summary Matt opens the show deep into Anaheim fatigue and the familiar HYROX arc where Day 3 feels brutal until racing resets everything. The conversation quickly turns to operational issues, including recovery zones, judging standards, and penalties, with frustration over unclear rules and inconsistent enforcement, particularly around wall balls and line calls. The episode centers on Greyson Kilgore's medical incident, with Greyson joining to explain what he felt during the race, how medical handled the situation, and why athletes need to distinguish between normal suffering and real warning signs. The discussion expands to cumulative load, ego, and the strength of the HYROX community, before wrapping with Anaheim course takeaways, Melbourne broadcast notes, and a clear split between what is confirmed and what remains rumored regarding Elite 15 qualification changes. Plus live from the Anaheim weekend, interviews with several Amazfit athletes, plus coaches and community voices: Julia Dorsey (pre-race) Brian Segher, Resolute Coffee Julia Dorsey with Kat Todorovic (post-race) Wade Critides with Greg O'Brien Brittany McCall and Leanna Girard Bethany Sachtleben (pre-race) Bethany Sachtleben with Christian Vitagliano (post-race) Molly Arena Aycan Kara Samantha Faddis Matt Tralli (pre-race) Matt Tralli (post-race) Listen on Apple or Spotify Support us through The Cup Of Coffee Follow Hybrid Fitness Media on IG    

Tackling central nervous system (CNS) disease in EGFR-mutated non-small cell lung cancer “is a huge problem, both from a quality-of-life perspective for patients and also from a longevity perspective,” explains Sid Devarakonda, MD, director of thoracic medical oncology at Swedish Cancer Institute in Seattle and clinical associate professor at Washington State University. He speaks with Aakash Desai, MD, MPH, associate director of the Phase 1 and Precision Oncology program at the University of Alabama at Birmingham, about how CNS metastases inform choices between regimens. Dr. Devarakonda also discusses how the recent U.S. Food and Drug Administration approval of subcutaneous amivantamab (Rybrevant Faspro) may change his approach. “[Y]ou still need to be comfortable managing some of the toxicities that still persist, even with the subcutaneous formulation, but it's terribly convenient from a practical perspective,” he notes. Dr. Desai and Dr. Devarakonda reported various financial relationships.

Joined by Heidi (Unfiltered Rise) to discuss Exploding Head Syndrome and Spontaneous Combustion. What are these fascinating anomalies, and why do they occur? Is there something more sinister at work? Why have witness accounts of spontaneous combustion disappeared? Are there military weapons involved? Find out!   Follow Heidi at www.unfilteredrisepodcast.com IG @unfilteredrise_podcast  X @UnfilteredRise On Patreon and Spotify     #ExplodingHeadSyndrome #EHS #SpontaneousCombustion #brainzap #explosion #fireworks #medications #CNS #neurons #brainsynapses #sleep #sleepparalysis #withdrawal #Magnesium #VitBdeficiency #loudnoise #sleepdisturbance

Drs. Drago and Traina explore the evolving landscape of managing central nervous system (CNS) metastases in HER2+ breast cancer, highlighting recent advances and clinical results in targeted therapies, including neratinib, tucatinib, and trastuzumab deruxtecan, that offer new hope for patients with brain metastases.

In today's episode we are sitting down with CrossFit Games athlete Leslie Franklin to hear all about her preparation for, experience at and takeaways from competing! What's new? Leslie's journey to the CF Games. 2023 shoulder injury.  2024 spent getting ready to qualify in 2025.  Watching the CF Games in Summer 2024. Legends Championship Winter 2024.  How did that help prepare you for the Games? CF Games qualification process- what's it look like? How did you place? Once qualified, how did training change? What did food and supplementation look during this phase? CF Games in Columbus.  Talk about nerves and 1st event. How did having a whole crew there to support you help or did it add more pressure? How did you perform and execute, and what do people need to understand from your placing while executing extremely well? What was your biggest thing you learned? What was your favorite most enjoyable part and least favorite? Talk about the weeks post comp, and how the CNS was fried. What's next???  IFBB Pro Stage? Closing thoughts Links: PHAT Muscle Supps- www.phatmuscleproject.com  John:IG: @teamgorman Email: john@team-gorman.net Lisa:IG: @nutritioncoachingandlife Email: lisa@nutritioncoachingandlife.comWebsite: www.nutritioncoachingandlife.com Info IG: @leslie_lilbadass

What if protein degradation could address neurodegenerative diseases, not just cancer? In this episode, Dr. Angela Cacace, CSO at Arvinas, speaks with Dr. Talar Hopyan, Global Head of CST at Syneos Health, about how the company is advancing a degrader targeting LRRK2 in Parkinson's disease and why early-stage signals in healthy volunteers are raising new possibilities for CNS care. They discuss how Arvinas is engineering blood-brain barrier-penetrant molecules, the translational challenges in neurodegeneration and what's required to move from platform to patient. What you'll learn: How Arvinas is expanding targeted protein degradation into neurology Why LRRK2 degradation is a promising approach for Parkinson's disease What it takes to translate platform innovation into measurable clinical outcomes The views expressed in this podcast belong solely to the speakers and do not represent those of their organization. If you want access to more future-focused, actionable insights to help biopharmaceutical companies better execute and succeed in a constantly evolving environment, visit the Syneos Health Insights Hub. The perspectives you'll find there are driven by dynamic research and crafted by subject matter experts focused on real answers to help guide decision-making and investment. You can find it all at https://www.syneoshealth.com/insights-hub. Like what you're hearing? Be sure to rate and review us! We want to hear from you! If there's a topic you'd like us to cover on a future episode, contact us at podcast@syneoshealth.com.

Listen Online: About this episode: The First Lady of Nutrition welcomes Dr. Jeremy Chatfield, DDS of Northwest Natural Dentistry, for a fascinating deep dive into one of the most overlooked foundations of detox and overall health: sleep. Dr. Chatfield (a/k/a The Sleep Dentist) explains why activating the brain for peak detoxification begins with high-quality sleep—and how hidden sleep-breathing disorders can quietly push the body into a constant fight-or-flight state. Together, Ann Louise and Dr. Chatfield unpack the surprising role of tongue ties (a major yet often missed cause of sleep apnea and snoring), why nasal breathing is essential for brain and body repair, and how airway dysfunction can ripple into everything from fatigue to inflammation. Listeners will learn how modern solutions like orthodontics, laser therapy, and myofunctional exercises can restore proper breathing—and why nutrition plays a pivotal role in calming airway irritation. Ann Louise also highlights her go-to natural antihistamine, Luteolin, which outperforms many over-the-counter options without the unwanted side effects. If you've been struggling with poor sleep, snoring, mouth breathing, or unexplained fatigue, this episode offers practical, actionable insights you won't want to miss. Learn more about Dr. Chatfield's work at: https://justbreathedds.com/The post Why Nasal Breathing is Non Negotiable for Deep Sleep and Detox first appeared on Ann Louise Gittleman, PhD, CNS.

Clinicians often zoom in on the knee with an acute meniscus tear, but the body usually has other plans.  In this episode, I walk through two client cases who arrived with classic meniscal presentations: pain, swelling, and loss of flexion. But the real driver of their pain at that assessment revealed itself only when I followed LTAP® findings back to the central nervous system.I break down how CNS tension alters dynamic alignment, hip mechanics, and tibiofemoral arthrokinematics, and why this pattern shows up so often in clients with knee pain. You'll hear exactly how I used the LTAP® to identify the true restriction and why the CNS initially mattered more than local knee work.In this episode, you'll learn:• How CNS tension alters gait, hip rotation, and knee loading during daily movement• Why addressing cranial containers can transform lower-extremity biomechanics• How simple sensory-driven treatments can reduce symptoms in structurally injured knees• When to treat locally, when to treat globally, and how to make that call with confidenceThis episode Is a practical reminder that system-level clarity leads to better outcomes, whethers it's in acute or chronic client cases.Resources & Links Mentioned In This Episode:Episode 86: Decoding The Nervous System For Health ProsEpisode 94: Understanding The Piriformis PuzzleLearn the LTAP® In-Person in one of my upcoming coursesConsidering the viscera as a source of musculoskeletal pain and dysfunction is a great way to ensure a more true whole body approach to care, however it can be a bit overwhelming on where to start, which is exactly why I created the Visceral Referral Cheat Sheet. This FREE download will help you to learn the most common visceral referral patterns affecting the musculoskeletal system. Download it at www.unrealresultspod.com=================================================Watch the podcast on YouTube and subscribe!Join the MovementREV email list to stay up to date on the Unreal Results Podcast and MovementREV education. Be social and follow me:Instagram | Facebook | Twitter | YouTube

Lídia Bodoque i Jordi Fusté han estat prop de vint anys acompanyant sitgetans en la pràctica esportiva a les instal·lacions del Club Natació Sitges, ho feien en tant que professionals del fitness amb vocació per la seva feina i amb l'afegit d'un amor i un vincle amb el club i amb el municipi del que ara s'han hagut d'acomiadar. Lamenten la desaparició del club i desitgen sobretot que es pugui mantenir la piscina com a seu del nou Club Esportiu Aquàtic Sitges hereu del CNS. Pel que fa a les instal·lacions asseguren que són idíl·liques per a la pràctica esportiva però que requereixen de bona gestió, el que segurament ha estat el mal d'aquest club sitgetà. Amb tots dos conversem sobre el Club Natació i sobre el món del fitness i els gimnasos ara que en neixen de nous. L'entrada Jordi i Lídia, professionals del fitness i vint anys al Club Natació Sitges ha aparegut primer a Radio Maricel.

Endometriosis is finally being understood for what it truly is: a whole-body inflammatory, immune-dysregulating disease that affects far more than the pelvis—and far more than just your period. If you've ever felt dismissed by doctors, confused by contradictory information, or overwhelmed by your symptoms, this conversation is going to feel like someone finally turning on the lights.In this interview, I sit down with Dr Jessica Drummond! Dr. Jessica Drummond, DCN, CNS, PT, NBC-HWC, has been passionate about supporting, caring for, and empowering people who struggle with women's and pelvic health concerns throughout her 24 year career working as a physical therapist and clinical nutritionist.Dr. Drummond's trademarked approach is holistic, multi-pronged, and comprehensive, which combines science-informed research, functional nutrition application, lifestyle medicine strategies, nervous system regulation, mind-body connection, hormone balance, physical & manual therapy, and so much more. While her private clients hold a special place in her heart, Dr. Jessica Drummond is equally passionate about educating and supporting clinicians and wellness professionals to become certified health coaches so they can confidently and safely provide integrative tools and treatment to their clients.In this in-depth interview, we unpack 20+ years of clinical experience and research to help you understand:

Moxifloxacin is a fourth-generation fluoroquinolone that works by inhibiting bacterial DNA gyrase and topoisomerase IV—two enzymes essential for DNA replication, repair, and transcription. By blocking both targets, it provides broad-spectrum activity against gram-positive, gram-negative, and atypical pathogens. Its enhanced gram-positive coverage, especially against Streptococcus pneumoniae, distinguishes it from earlier fluoroquinolones like ciprofloxacin. Pharmacokinetically, moxifloxacin has excellent oral bioavailability, meaning the PO and IV doses are essentially interchangeable. It distributes well into tissues like the lungs and sinuses, making it a frequent choice for respiratory infections. With a long half-life of about 12 hours, once-daily dosing is standard. Adverse effects are similar to the fluoroquinolone class, with concerns including tendonitis and tendon rupture, QT interval prolongation, CNS effects like confusion or agitation—particularly in older adults—and the risk of peripheral neuropathy. Moxifloxacin is especially notable for a higher propensity toward QT prolongation compared with some of its peers, making it important to avoid in patients with existing QT issues or those taking other QT-prolonging medications. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

Can an acute injury, like a sudden shoulder subluxation, still have visceral or neural influences worth treating? In this episode, I unpack why even the most straightforward orthopedic cases often have deeper layers that shape pain, recovery, and movement quality.I share a case of a collegiate softball athlete whose chronic subluxations suddenly flared after a rough bout of COVID and why her lack of progress with rehab made perfect sense once I assessed her through a whole-organism lens view. You'll hear how lung restrictions, altered thoracic mobility, and neural tension were driving poor scapular mechanics that her strengthening program could never overcome. A few targeted treatments changed her symptoms instantly and shifted her entire rehab trajectory.In this episode, you'll learn:• Why acute pain presentations often include visceral and CNS influences, even when trauma is obvious• How post-infection thoracic mobility changes can alter scapular mechanics and create instability patterns• How to differentiate true tissue instability from altered neural output• Practical ways to influence supraclavicular, phrenic, and brachial plexus input when local loading isn't toleratedThis episode will help you sharpen your lens for the cases that look simple on the surface but demand deeper, more connected reasoning underneath.Resources & Links Mentioned In This Episode:Episode 16: Why The Shoulder Comes LastEpisode 69: Why Your Shoulder Treatments Might Not Be EnoughChange your approach to treating shoulder pain and dysfunction with my course - Never Treat The Shoulder FirstLearn the LTAP® In-Person in one of my upcoming coursesConsidering the viscera as a source of musculoskeletal pain and dysfunction is a great way to ensure a more true whole body approach to care, however it can be a bit overwhelming on where to start, which is exactly why I created the Visceral Referral Cheat Sheet. This FREE download will help you to learn the most common visceral referral patterns affecting the musculoskeletal system. Download it at www.unrealresultspod.com=================================================Watch the podcast on YouTube and subscribe!Join the MovementREV email list to stay up to date on the Unreal Results Podcast and MovementREV education. Be social and follow me:Instagram | Facebook | Twitter | YouTube

In this episode of the Midweek Takeaway, Phil Carroll and Kevin Hornsby are joined by Anthony Tennyson, CEO of Solvonis Therapeutics (LSE: SVNS), to break down the major news that addiction candidate SVN-015 has been accepted into the US NIH/NIDA Addiction Treatment Discovery Program — opening the door to fully funded preclinical work and potentially up to $3m per year in non-dilutive grants. Anthony also discusses progress across Solvonis' CNS pipeline, the company's AI-powered discovery engine, and the widening valuation gap between UK and US biotech markets. Disclaimer & Declaration of Interest This podcast may contain paid promotions, including but not limited to sponsorships, endorsements, or affiliate partnerships. The information, investment views, and recommendations provided are for general informational purposes only and should not be construed as a solicitation to buy or sell any financial products related to the companies discussed. Any opinions or comments are made to the best of the knowledge and belief of the commentators; however, no responsibility is accepted for actions based on such opinions or comments. The commentators may or may not hold investments in the companies under discussion. Listeners are encouraged to perform their own research and consult with a licensed professional before making any financial decisions based on the content of this podcast. 

She grew up with no roadmap, no support, and no clear path forward. One pull-up changed everything, leading her into the Army and a career in explosive ordnance disposal. Twelve years later, Kaitlyn Hernandez built a life defined by discipline, resilience, and service. She shares how daily discomfort, purpose, and small hard choices shaped her mindset, helping her run a bomb-suit mile, set a world record, and tackle some of the military's toughest challenges.   3 Key Learnings: Small daily challenges build discipline, mental toughness, and high-stakes performance Leaning into discomfort strengthens resilience, focus, and decision-making Purpose, service, and consistent action create long-term endurance and growth   3 Tools / Frameworks: Controlled discomfort protocols: rucking, cold exposure, physical stress CNS reset through structured challenges Mindset reframing: "I get to, not I have to" and "Fix your face" to shift state   Timestamps: 00:51 – Growing up without structure and finding purpose in service 02:27 – Joining the military and discovering direction 04:08 – How she chose the bomb squad and what EOD means 07:48 – What EOD teams do during stateside and presidential missions 09:14 – How bomb suit training works and what "bomb suit dumb" means 10:28 – Breaking the world record and the strategy behind it 12:59 – Running a bomb-suit mile on all seven continents 13:39 – Preparing for the Antarctica mission and raising awareness 18:50 – Her step-by-step advice for building resilience through daily discomfort   Start with one hard thing, lean into discomfort, and build discipline through daily action.  

Geo Espinosa, ND, LAc, CNS, a well-known naturopathic doctor specializing in urological health at NYU Langone Hospital, and host of the upcoming Prostate Cancer Summit 2.0, scheduled for December 13th-17th, a free online event designed to provide comprehensive information on prostate cancer diagnosis, treatment, and management. 

Geo Espinosa, ND, LAc, CNS, a well-known naturopathic doctor specializing in urological health at NYU Langone Hospital, licensed acupuncturist, and certified Functional Medicine practitioner, discusses prostate health, including the latest advances in prostate cancer treatment and the importance of a balanced approach between natural and conventional medicine. Dr. Espinosa also highlights the upcoming Prostate Cancer Summit 2.0, scheduled for December 13th-17th, a free online event designed to provide comprehensive information on prostate cancer diagnosis, treatment, and management. The conversation covers PSA testing, new diagnostic tools, advanced treatment options like androgen deprivation therapy, and the benefits of exercise and diet in managing prostate health.

In this episode of the Atomic Anesthesia Podcast, host Dr. Rhea Temmermand provides a detailed pharmacology review of propofol, the main IV sedative hypnotic used for induction, maintenance, and procedural sedation in anesthesia practice. The episode covers propofol's drug class and chemistry, its lipid emulsion formulation and infection risk, and key physicochemical properties including high lipophilicity and protein binding. Listeners learn the mechanism of action at the GABA A receptor, translating into CNS effects, cardiovascular and respiratory depression, and no analgesia. The discussion walks through pharmacokinetics and context‑sensitive half‑time in a clinically practical way, tying concepts to infusion planning and dosing strategies for various cases. Major adverse effects, toxicity including propofol infusion syndrome, allergy and infection‑control practices, and drug synergies are highlighted, with high‑yield clinical pearls on patient selection, hemodynamics, and airway rescue.REFERENCES: Nagelhout JJ, Elisha S, Heiner JS, eds. Nurse Anesthesia. 7th ed. Elsevier; 2022.Flood P, Rathmell JP, Urman RD, eds. Stoelting's Pharmacology & Physiology in Anesthetic Practice. 6th ed. Wolters Kluwer; 2021.Katzung BG, ed. Basic & Clinical Pharmacology. 14th ed. McGraw-Hill Education; 2018.Want to learn more? Grab our Cardiac Pharm Course --> [HERE]⚛️ CONNECT:

Did you know that there is hope for patients diagnosed with ALS? Amyotrophic Lateral Sclerosis (ALS), the debilitating neurodegenerative disease commonly known as “Lou Gehrig's Disease,” is influenced by genetics and environmental factors, including living near bodies of water frequently impacted by harmful algal blooms. Join Food Sleuth Radio host and Registered Dietitian, Melinda Hemmelgarn for her conversation with Coco Newton, RD, MPH, CNS, a registered dietitian and holistic practitioner with expertise in functional medical nutritional therapy for improving the diet quality and quality of life for those diagnosed with ALS. Newton has been involved with Healing ALS: www.healingALS.org. She references the ALS Clinic at Duke University: https://alsclinic.duke.edu/our-research/ and the international conference on ALS and Motor Neurone Disease will be held Dec 5-7 in San Diego, CA: https://symposium.mndassociation.org/programme/. To learn more about algal blooms and neurodegenerative disease, see: https://www.eurekalert.org/news-releases/1087706 Related Websites: https://www.coconewton.com/

In this special episode of The First Lady of Nutrition, Ann Louise Gittleman sits down with internationally recognized integrative physician Dr. Jacob Teitelbaum, a leading expert on chronic fatigue, post-viral syndromes, and Long COVID recovery. Together, they unpack the most persistent symptoms—fatigue, brain fog, poor sleep, shortness of breath, and lingering inflammation. Dr. Teitelbaum clarifies how Long COVID differs from other post-viral conditions and why, despite its complexity, it is highly treatable. Listeners will also hear about two simple at-home tests Dr. Teitelbaum recommends—and he's generously offered to send them, along with personalized recovery guidance, to anyone who emails him at fatiguedoc@gmail.com. You are also invited to explore his book, You Can Heal From Long COVID, available at https://amzn.to/4ieDZKr This is a hopeful, practical conversation filled with real solutions for anyone still working to regain their health after COVID. The post The Mystery of Long COVID Solved first appeared on Ann Louise Gittleman, PhD, CNS.

Matias interviews James (Jim) Gorman MD PhD from the Wyss Institute. Jim is Principal Investigator on the Wyss Institute Brain Targeting Program (BTP). Jim leads a team developing new approaches to transport drugs through the blood brain barrier (BBB) into the CNS.In this episode, we discuss:Why the BBB blocks most modern drugs from entering the brain, creating the biggest bottleneck in neuroHow brain shuttles hijack natural transport pathways like the transferrin receptor to move drugs across the BBBHow new modalities that reach the brain can potentially treat diseases like Alzheimer's, Parkinson's, ALS, and lysosomal disorders Why delivery route of shuttles enable IV or subcutaneous dosing instead of invasive intrathecal injectionsHow early data shows that shuttle-enabled antibodies clear amyloid faster, at lower doses, and with fewer side effectsHow the field is accelerating through a pre-competitive consortium model that lets multiple companies share shuttle platformsCredits:Created by Greg Kubin and Matias SerebrinskyHost: Matias SerebrinskyProduced by Caitlin Ner & Nico V. Rey Find us at businesstrip.fm and psymed.venturesFollow us on Instagram and Twitter!Theme music by Dorian LoveAdditional Music: Distant Daze by Zack Frank

In this episode of The Nurse Practitioner Podcast, Julia Rogers, DNP, APRN, CNS, FNP-BC, FAANP and Christina Cantey, DNP, FNP-C, AACC, CCK discuss the transcatheter revolution in the treatment of valvular heart disease.

Trauma lives in the body—sometimes long after the crisis ends. In this episode, nutritionist and trauma specialist Meg Bowman (MS, CNS, LDN, CHES) breaks down how food, stress, safety, and the nervous system are woven together.You'll learn why your body might still feel unsafe, how trauma impacts digestion and hunger, and what compassionate nutrition can do to support betrayal trauma recovery. We also explore simple practices to help your body shift out of survival mode.Perfect for anyone navigating relational trauma, burnout, chronic stress, or dysregulation.Connect with Meg:This Is Your Body on Trauma bookWebsiteChapters00:16 Introducing Meg Bowman01:47 Holistic Healing and Trauma02:44 Nutrition and Trauma Recovery04:09 Practical Tips for Nutrition and Safety08:08 Challenges and Self-Compassion11:59 Polyvagal Theory27:44 Holiday Nutrition and Emotional TriggersRegister Now!Rise, Renew, Restore Somatic Healing Retreat in Costa Rica -  Ready to experience deep somatic healing? Join us this July for a transformative 5-day intensive created specifically for women healing from betrayal trauma or navigating divorce. This is your opportunity to reconnect with your body's wisdom, release what you've been carrying, and heal alongside other women who truly understand your journey. Revive and Thrive Somatic  Intensive for Women - Join us for a transformative four-day somatic healing intensive for women carrying trauma and tension in their bodies. Experience gentle release through expert-guided breathwork, brainspotting, energy healing, and nature immersion as you reclaim your body. Intensive is Jan 27-30, 2026 in Spanish Fork, Utah. We don't want finances to get in the way of your healing. Scholarships and payment plans (including buy now, pay later options) are available for all of our intensives. Learn more and see if you qualify.Questions or topics you'd like us to address? Send us an email with “Choose To Be” as the subject to podcast@chooserecoveryservices.com. Watch us⁠ on YouTube.Follow us on Instagram: @choose_recovery_services⁠Schedule⁠ a complimentary consultation.Join our email list to be notified when new episodes air.More from Choose Recovery ServicesBeyond the Facade Podcast - Luke Gordon hosts a podcast geared toward helping men live authentically and in harmony with their values.Choose Healing - Weekly support group for women who have recently experienced betrayal and are needing help coping with the symptoms of trauma. Intensives - Accelerate your healing journey with one of our intensives. Foster connection with others who share similar experiences, creating an immersive environment that enables profound transformation in a short period of time.Healing Hearts - For couples seeking healing after betrayal. It emphasizes the development of empathy, integrity, and authentic intimacy. Help. Her. Heal - This program is for men seeking to learn more about empathy, conflict resolution, and healthy communication. Beyond the Facade: Men's Healing Group - We help men move through the pains of addiction, relationship healing, managing emotions, and moving past shame. ⁠⁠⁠⁠⁠⁠The Empowered Divorce Podcast⁠⁠⁠⁠⁠⁠ with Amie Woolsey for those who are leaning toward divorce.⁠⁠⁠⁠⁠⁠Dating From Within - Amie Woolsey hosts this workshop which teaches you how to date yourself first. Should I Stay or Go? - Self-paced course designed to be a companion on your journey toward self-discovery and personal empowerment. Trauma Trigger Kit - Triggers can come out of nowhere. Keep a Trauma Trigger Kit on hand to help you use your five senses to stay grounded and connected to yourself.Believing in You - In this program Amie teaches you how to work WITH your brain instead of against it. Intimacy Within ⁠- Amie's self-paced course and guidebook will walk you through the seven levels of intimacy. Learn how to embrace authenticity and vulnerability even in the face of potential rejection.

This week on the Garage Gym Athlete Podcast, we're running three completely different scientific studies through the grinder—and none of us saw each other's ahead of time. Expect surprises, arguments, and some actionable training takeaways you can start using immediately. Jerred digs into a kettlebell snatch protocol that boosted VO₂ max without running. Joe explores how dietary nitrates (think beets, spinach, arugula) improve isometric endurance by 25%. And Dave breaks down a 2025 study showing how heavy strength work dramatically improves running economy, durability, and time-to-exhaustion in well-trained runners. We also kick things off with an update on last week's isometric training experiment—spoiler: it was brutal—and end with a practical roundtable on supplements we actually use. If you train in a garage gym, want science-backed performance strategies, and enjoy a little misery mixed with progress…this one's for you. 00:00 – Intro: This week's study mash-up 00:30 – Isometric training update & why Jerred is wrecked 02:25 – Immovable objects, heavy loads & iso strategy 03:47 – Dave digs into CNS fatigue from the iso session 04:52 – Transition: Let's get into the studies 05:16 – Study 1: Strength training improves running performance 08:48 – 31% improvement in time-to-exhaustion 10:27 – Jerred on heavy lifting for runners 12:04 – Joe on balancing strength, speed & endurance 13:56 – The truth about soreness & "gaining mass" fears 15:28 – Study 2: Nitrates boost isometric endurance (Joe) 18:48 – How much beets/spinach you actually need 19:26 – Joe's real-life beet adventure (never pickled…) 20:53 – Study 3: Increase VO₂ max by 6% with kettlebells (Jerred) 21:16 – VO₂ max simplified — oxygen demand & oxygen debt 23:16 – The 15s on / 15s off kettlebell snatch protocol 25:17 – Circuit training vs kettlebell intervals 27:39 – How to implement the protocol in real training 30:36 – Kettlebells vs running for conditioning 33:32 – Supplement roundtable: what we actually take 34:29 – Joe: nitrates & tart cherry 36:05 – Dave: creatine, protein & coffee 39:28 – Jerred: electrolytes & hydration 42:45 – Are electrolytes supplements or just life? 44:22 – Closing thoughts & "Kill Comfort" reminder

In this jam-packed episode, the First Lady of Nutrition sits down with world-renowned fat expert Dr. Udo Erasmus, author of the groundbreaking classic Fats That Heal, Fats That Kill: The Complete Guide to Fats, Oils, Cholesterol and Human Health. With more than 45 years of research under his belt, Dr. Erasmus brings clarity to one of the most confusing topics in nutrition—the truth about seed oils. Together, Ann Louise and Dr. Erasmus explore the delicate balance between Omega-3 and Omega-6 fats and reveal why it's not the seeds themselves that cause harm—but rather the way oils are processed. You'll discover how high-heat, solvent extraction methods damage fragile oils, destroy essential nutrients, and leave behind toxic residues that can wreak havoc on your health. Dr. Erasmus also explains why more health damage comes from damaged oils than from any other single factor—and how using the right oils in the right way can transform your energy, metabolism, and longevity. Learn why fresh, organic, cold-pressed oils are vital, why you should never fry with them, and how to store them properly to protect their healing power. This spirited discussion is packed with “truth bombshells” that will forever change the way you look at fats and oils. Tune in and find out how to get your oils straight—and your health back on track. The post The Real Truth About Seed Oils first appeared on Ann Louise Gittleman, PhD, CNS.

Can you gain real muscle with isometric holds and little to no equipment? We break down a 2025 study comparing long-muscle-length isometric training to full range of motion isotonic work for quadriceps hypertrophy in trained lifters. We translate the science into simple setups you can use at home or in a hotel gym, explain why long-length positions matter, how to hit a true 10 RPE on static holds, and when to pair pre-exhaust sets with isometrics for serious growth without beating up your joints. What you'll learn: Isometric vs isotonic for hypertrophy and when isometrics can win How to find and hold true long-length positions for chest, back, quads, and hamstrings Making bodyweight isos hard enough to matter with 30-second max-effort holds Joint-friendly use cases for tendons, pain, deload weeks, and travel A plug-and-play isometric session you can try today Sample session: Pull: Chin-over-bar hold to failure, 4 sets Push: Handstand push-up iso 3 to 6 inches off the floor, to failure, 4 sets Quads: Wall sit at or just below parallel, 30-second max holds, 4 to 6 sets Unilateral: Rear-foot-elevated split-squat iso, back knee 1 inch off floor, 30 seconds, 4 sets per leg Optional overload: Pins, fixed bands, or plates on lap for wall sits Timestamps: 00:00 Intro 01:00 The 2025 study in plain English 03:30 Why long-length isometrics drive growth 06:50 Execution cues: 30s holds and true 10 RPE 08:30 Rehab and tendon applications 10:40 Pre-exhaust plus isos for hypertrophy 12:45 Minimal equipment programming ideas 15:10 Full sample isometric workout 20:20 Soreness, CNS load, and recovery 23:10 Movement skill benefits and coaching cues 27:45 Key takeaways and next steps Links: Free trial of our programming: https://garagegymathlete.com

Grazing. Chronic stress. Poor sleep. Rushed meals. Sitting for long hours. Underfueled workouts. Estrogen decline. There's a lot more behind our fasting glucose and A1C than how many carbs we eat. This week we return to one of the most consistently requested topics: blood sugar meaning and management with Liz McKinney, CNS, LDN. We explore what glucose spikes really mean, why time-in-range and variability matter more than a single peak, and how stress, sleep, and even eating speed affect your numbers. We cover carb timing, meal sequencing, post-meal walks, creatine, why under-fueling can make exercise spikes worse, and much more so you can keep glucose working for your performance and overall health.Liz McKinney, CNS, LDN, heads up the clinical nutrition team at Nutrisense. Liz holds a Master of Science degree in Clinical Nutrition and Integrative Health and is a board-certified nutrition specialist (CNS) as well as a licensed dietitian nutritionist (LDN). In her time as a nutritionist, Liz has educated and counseled hundreds of clients in areas such as weight loss, hormonal imbalances, and gastrointestinal diseases. Her approach is rooted in the tenets of functional medicine, and she strives to identify the root cause of the issue instead of simply treating the symptoms. She realizes there is no one-size-fits-all approach to achieving optimal health and feels it is crucial to be in an equal partnership with her clients. Resources What to Know About Prediabetes and Menopause with Val Schonberg, RDN, CSSD (Episode 202)Sign up for our FREE Feisty 40+ newsletter: https://feisty.co/feisty-40/Join our Feisty Winter Training for Cyclists at https://feisty.co/ and look for the yellow banner at the top of the page. Use code HITPLAY50 to save $50 Learn More and Register for our 2026 Tucson Bike Camp: https://feisty.co/events/gravel-camp-x-bike-mechanic-school/ Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% offWahoo KICKR RUN: Use the code FEISTY to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/maTzL

Drs. Cooper and Rotow review the challenges of CNS involvement in HER2+ NSCLC, emphasizing the importance of baseline and ongoing brain imaging, and the emerging understanding of CNS penetrance for HER2-targeted therapies. They explore strategies for managing brain metastases, including balancing local therapies, including radiation with systemic treatments, and highlight the need for multidisciplinary approaches and further research on CNS activity in clinical trials.

Synopsis: Jim Tananbaum, Founder & CEO of Foresite Capital, joins Rahul Chaturvedi to dissect the patterns driving biotech innovation, the role of macroeconomic cycles in venture performance, and how disciplined science fuels enduring investment success. Drawing from three decades across entrepreneurship and venture leadership, Jim reflects on his path from co-founding drug discovery startups with Harvard collaborators to building one of the most respected investment firms in life sciences. He unpacks how interest rate environments shape fund vintages, why AI is emerging as the next transformative platform, and how investors can identify enduring opportunities amid volatility. Their discussion spans valuation compression, AI-driven discovery, CNS and Alzheimer's innovation, and the geopolitical forces influencing biotech globally. Jim's perspective offers a masterclass in balancing scientific rigor with strategic foresight — and in positioning capital where breakthrough innovation meets sustainable impact. “Lean into areas where there's likely to be immense change,” Jim advises — a principle as relevant to biotech investing as it is to shaping the future of healthcare itself. Biography: Jim is the founder and CEO of Foresite Capital, a healthcare investment firm founded in 2011 that has approximately $3.5B in assets under management. Jim assembles the people, ideas, and money needed to launch products that save lives and improve healthcare. During the last three decades, Jim has been a thought partner for some of the fastest-growing companies of their generation, including 10x Genomics (Nasdaq: TXG), Amerigroup (Nasdaq: ANTM), and Jazz Pharmaceuticals (Nasdaq: JAZZ). Jim's entrepreneurial experience began at Harvard Business School when he co-founded GelTex Pharmaceuticals (Nasdaq:GENZ). With less than $80M in funding, GelTex brought two drugs to market, and the company was acquired in 1999 for $1.4B. Jim was also the founding chief executive of Theravance, Inc. Under his tenure, he raised over $350M. Theravance has since split into two parts, one of which is now part of GSK's respiratory franchise through a joint venture, Innoviva (Nasdaq: INVA), and the other was spun out into Theravance Biopharma, Inc. (Nasdaq: TBPH). Together, they achieved a market capitalization that exceeded $4B. Jim's investment experience includes co-founding Prospect Ventures and, earlier in his career, being a partner of Sierra Ventures, where he established its healthcare services investment practice. Jim graduated from Yale with a BS and BSEE in Applied Math and Electrical Engineering/Computer Science. He then earned an MD from Harvard, graduating from the Harvard/MIT HST Program. He also earned an MBA from Harvard while playing rugby.

What if true longevity isn't found in quick fixes, but in the world you create around your body and mind? In this powerful episode, Dr. Mindy is joined by functional health pioneer Dr. Josh Axe for a deep dive into the real foundations of aging, vitality, and lasting wellness. Dr. Axe shares his inspiring story of recovery from a near-fatal spinal infection and how it reshaped his understanding of healing. Together, they explore how your everyday choices, mindset, environment, and ancient wisdom influence your health, far beyond genetics. To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep312 Dr. Josh Axe, DC, DNM, CNS, is a doctor of chiropractic, certified doctor of natural medicine, clinical nutritionist, leadership expert and highly successful entrepreneur, with a passion to help people eat healthy and live a healthy lifestyle. He earned his doctorate from Palmer College and his Master of Science in Organizational Leadership from Johns Hopkins University. Dr. Axe is the cofounder and CVO of Ancient Nutrition, founder of DrAxe.com, and founder of The Health Institute. His businesses have ranked on the Inc. 500 fastest growing companies. He is the bestselling author of Think This Not That, Eat Dirt, Keto Diet, Ancient Remedies, and The Biblio Diet. He regularly teaches lectures and trains entrepreneurs on leadership, mindset, and self- development. Josh is married to his wife, Chelsea, and they have two daughters. They live between Nashville, TN and Dorado, PR and enjoy cooking, staying active swimming and cycling, and prioritize time for their faith and family. Check out our fasting membership at https://esetacademy.drmindypelz.com. Please note our medical disclaimer.

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: What are the big differences between lifting heavy vs lighter? (2:35) Training your CNS for change. (21:46) The unliftable man. (28:24) Leverage. (29:47) Kids say the darndest things. (32:42) Coaching your son. (33:52) Learning how to lose. (35:45) The science behind Brain.fm. (37:34) Subliminal messaging. (42:58) Social media platforms as weapons. (45:07) The locus of control. (47:40) Correlation of eating grass-fed meat and inflammation. (49:56) #ListenerLive question #1 – How do I maintain a healthy relationship with food and fitness while dealing with SIBO? (55:13) #ListenerLive question #2 – Do you think the root issue here is overtraining, compromising recovery, or more likely a neurological/sensory driver of these asymmetries? (1:05:11) #ListenerLive question #3 – Should I increase calories even though I've been doing this for a year now and continue to bulk, or should I concentrate on cutting still to lose fat? (1:21:16) #ListenerLive question #4 – How much of an impact could HRT (specifically estrogen and testosterone) have on my life, especially body composition and training/lifting goals? (1:30:54) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit Brain.fm for an exclusive offer for Mind Pump listeners. ** Get 30 days of free access to science-backed music. ** Visit Butcher Box for this month's exclusive Mind Pump offer!  ** Available for a limited time, a curated box pre-filled with Mind Pump's favorite cuts — no guesswork! Butcher Box members who sign up through Mind Pump will receive: $20 OFF their first box, Free chicken breast, ground beef, OR salmon in every box for a whole year! ** October Special: MAPS GLP-1 50% off! ** Code GLP50 at checkout. ** Bret Contreras Tempo Hypertrophy IG Video Sal Di Stefano's Journey in Faith & Fitness – Mind Pump TV Johnny Coulon - Wikipedia Attentional modulation of neural entrainment to sound streams in children with and without ADHD The brain in flow: A systematic review on the neural basis of the flow state Resting state fMRI-based brain information flow mapping Mind Pump #912: How to Change Your Mental State with Music Oracle, Silver Lake and MGX will be main investors in TikTok U.S., sources say Visit Seed for an exclusive offer for Mind Pump listeners! **Promo code 25MINDPUMP at checkout for 25% off your first month's supply of Seed's DS-01® Daily Synbiotic** MP Holistic Health Mind Pump #2690: The NEW DIET Everyone Is Using For Fat Loss Visit Transcend for this month's exclusive Mind Pump offer! ** Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN!  Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE! ** Muscle Mommy Movement Mind Pump Podcast – YouTube Mind Pump Free Resources   People Mentioned Bret Contreras PhD (@bretcontreras1) Instagram Denis Roberts (@denis_kokushi) Instagram Jordan Shallow D.C (@the_muscle_doc) Instagram Justin Brink DC (@dr.justinbrink) Instagram LAUREN FITZ, M.D. (@drlaurenfitz) Instagram