Podcasts about CNS

In this episode of NucleCast, Adam interviews Dr. Rich Tighe, the president and CEO of Consolidated Nuclear Security, discussing the current operations and future outlook of the Y-12 National Security Complex. Rich explains the complex's historical significance, its current missions, and the challenges it faces in workforce recruitment and safety. The conversation also touches on modernization efforts, collaboration with design agencies, and the importance of community support. Rich shares his aspirations for the future, including the need for continued growth and innovation in nuclear security.Richard (Rich) Tighe is president and chief executive officer of Consolidated Nuclear Security, the Bechtel led management and operating contractor for the Y 12 National Security Complex in Oak Ridge, Tennessee, with a workforce of approximately 9,500. Tighe (pronounced “tie”) joined CNS in September 2022, and led the company through the separation of the Pantex Plant from CNS's management and operating contract. Before the separation, Tighe led a combined 13,500 employees through significant growth and record performance. As the National Nuclear Security Administration mission and project scope grew at the sites, CNS met all deliverables to the military under Tighe's leadership. Additionally, during his tenure, CNS added more than 1,500 team members, including engineers, scientists, professional staff, and craft workers, and both sites improved safety performance, achieving more than 12.6 million consecutive hours without a lost time injury. Under Tighe's leadership, CNS has been awarded a 2-year contract extension at Y-12.Before joining CNS, Tighe served for nearly 4 years as president and general manager of National Aerospace Solutions (NAS), the Bechtel-led test operations and sustainment contractor for the Arnold Engineering Development Complex at Arnold Air Force Base near Tullahoma,Tennessee. He also was manager of strategy, marketing, and business development for Bechtel's Nuclear, Security, and Environmental global business unit, an $8 billion business. He served as the NS&E representative to the Bechtel Group Marketing and Business Development Committee and represented Bechtel on the board of managers for NAS and Kwajalein Range Services.Tighe joined Bechtel in 2006 as marketing and business development manager; he was elected principal vice president in 2016 and senior vice president in 2023. Before his service with Bechtel, Tighe worked for Lockheed Martin at the Nevada Test Site for more than a decade, holding several scientific and management posts and ultimately advancing to assistant general manager for high-hazard test and evaluation.Tighe was a postdoctoral fellow in the Nuclear Science Division of the Lawrence Berkeley National Laboratory at the University of California.He earned a Ph.D. in experimental nuclear physics from the University of Notre Dame, Indiana, and a B.S. in physics from Loras College in Dubuque, Iowa.Socials:Follow on Twitter at @NucleCastFollow on LinkedIn: https://linkedin.com/company/nuclecastpodcastSubscribe RSS Feed: https://rss.com/podcasts/nuclecast-podcast/Rate: https://podcasts.apple.com/us/podcast/nuclecast/id1644921278Email comments and topic/guest suggestions to NucleCast@anwadeter.org

On this show Karolyn talks with saliva expert—yes, saliva!—Patti Milligan, PhD, RD, CNS, about how the science of saliva can influence our health. Dr. Milligan is an accomplished author and researcher and has taught corporate wellness programs through the US and Europe. She has even done a TedTalk about how understanding our saliva can help us make informed health decisions. It's time to find out what messages our saliva is sending us!Five To Thrive Live is broadcast live Tuesdays at 7PM ET and Music on W4CS Radio – The Cancer Support Network (www.w4cy.com) part of Talk 4 Radio (www.talk4radio.com) on the Talk 4 Media Network (www.talk4media.com).Five To Thrive Live Podcast is also available on Talk 4 Media (www.talk4media.com), Talk 4 Podcasting (www.talk4podcasting.com), iHeartRadio, Amazon Music, Pandora, Spotify, Audible, and over 100 other podcast outlets.

En este episodio exploramos a fondo el mutismo acinético, una de las manifestaciones más desconcertantes tras un daño cerebral grave. Hablamos de su base neurofisiológica, su relación con el sistema dopaminérgico y los circuitos prefronto-subcorticales, y cómo se diferencia clínicamente de otros estados de conciencia alterada. Recorremos también las opciones terapéuticas más prometedoras, desde la estimulación multisensorial y la verticalización robótica hasta técnicas de neuromodulación como la estimulación cerebral profunda, la estimulación medular o la tDCS. Un episodio técnico, narrativo y lleno de preguntas clínicas clave, pensado para quienes trabajan día a día con pacientes que aún no responden... pero que podrían hacerlo. Referencias del episodio: 1. Arnts, H., van Erp, W. S., Lavrijsen, J. C. M., van Gaal, S., Groenewegen, H. J., & van den Munckhof, P. (2020). On the pathophysiology and treatment of akinetic mutism. Neuroscience and biobehavioral reviews, 112, 270–278. https://doi.org/10.1016/j.neubiorev.2020.02.006 8 https://pubmed.ncbi.nlm.nih.gov/32044373/). 2. Arnts, H., Tewarie, P., van Erp, W. S., Overbeek, B. U., Stam, C. J., Lavrijsen, J. C. M., Booij, J., Vandertop, W. P., Schuurman, R., Hillebrand, A., & van den Munckhof, P. (2022). Clinical and neurophysiological effects of central thalamic deep brain stimulation in the minimally conscious state after severe brain injury. Scientific reports, 12(1), 12932. https://doi.org/10.1038/s41598-022-16470-2 (https://pubmed.ncbi.nlm.nih.gov/35902627/). 3. Arnts, H., Tewarie, P., van Erp, W., Schuurman, R., Boon, L. I., Pennartz, C. M. A., Stam, C. J., Hillebrand, A., & van den Munckhof, P. (2024). Deep brain stimulation of the central thalamus restores arousal and motivation in a zolpidem-responsive patient with akinetic mutism after severe brain injury. Scientific reports, 14(1), 2950. https://doi.org/10.1038/s41598-024-52267-1 (https://pubmed.ncbi.nlm.nih.gov/38316863/). 4. Bai, Y., Xia, X., Li, X., Wang, Y., Yang, Y., Liu, Y., Liang, Z., & He, J. (2017). Spinal cord stimulation modulates frontal delta and gamma in patients of minimally consciousness state. Neuroscience, 346, 247–254. https://doi.org/10.1016/j.neuroscience.2017.01.036 (https://pubmed.ncbi.nlm.nih.gov/28147246/). 5. Bai, Y., Xia, X., Liang, Z., Wang, Y., Yang, Y., He, J., & Li, X. (2017). Corrigendum: Frontal Connectivity in EEG Gamma (30-45 Hz) Respond to Spinal Cord Stimulation in Minimally Conscious State Patients. Frontiers in cellular neuroscience, 11, 251. https://doi.org/10.3389/fncel.2017.00251 (https://pubmed.ncbi.nlm.nih.gov/28828002/). 6. Bai, Y., Lin, Y., & Ziemann, U. (2021). Managing disorders of consciousness: the role of electroencephalography. Journal of neurology, 268(11), 4033–4065. https://doi.org/10.1007/s00415-020-10095-z (https://pubmed.ncbi.nlm.nih.gov/32915309/). 7. Cairns, H., Oldfield, R. C., Pennybacker, J. B., & Whitteridge, D. (1941). Akinetic mutism with an epidermoid cyst of the 3rd ventricle. Brain, 64(4), 273–290 (https://academic.oup.com/brain/article-abstract/64/4/273/332088?redirectedFrom=fulltext). 8. Chen, Q., Huang, W., Tang, J., Ye, G., Meng, H., Jiang, Q., Ge, L., Li, H., Liu, L., Jiang, Q., & Wang, D. (2025). Reviving consciousness: The impact of short-term spinal cord stimulation on patients with early-onset prolonged disorders of consciousness. Journal of Neurorestoratology, 13(1), 100143. https://doi.org/10.1016/j.jnrt.2024.100143 (https://www.sciencedirect.com/science/article/pii/S2324242624000500?via%3Dihub). 9. Clavo, B., Robaina, F., Montz, R., Carames, M. A., Otermin, E., & Carreras, J. L. (2008). Effect of cervical spinal cord stimulation on cerebral glucose metabolism. Neurological research, 30(6), 652–654. https://doi.org/10.1179/174313208X305373 (https://pubmed.ncbi.nlm.nih.gov/18513465/). 10. Corazzol, M., Lio, G., Lefevre, A., Deiana, G., Tell, L., André-Obadia, N., Bourdillon, P., Guenot, M., Desmurget, M., Luauté, J., & Sirigu, A. (2017). Restoring consciousness with vagus nerve stimulation. Current biology : CB, 27(18), R994–R996. https://doi.org/10.1016/j.cub.2017.07.060 (https://pubmed.ncbi.nlm.nih.gov/28950091/). 11. Della Pepa, G. M., Fukaya, C., La Rocca, G., Zhong, J., & Visocchi, M. (2013). Neuromodulation of vegetative state through spinal cord stimulation: where are we now and where are we going?. Stereotactic and functional neurosurgery, 91(5), 275–287. https://doi.org/10.1159/000348271 (https://pubmed.ncbi.nlm.nih.gov/23797266/). 12. De Luca, R., Bonanno, M., Vermiglio, G., Trombetta, G., Andidero, E., Caminiti, A., Pollicino, P., Rifici, C., & Calabrò, R. S. (2022). Robotic Verticalization plus Music Therapy in Chronic Disorders of Consciousness: Promising Results from a Pilot Study. Brain sciences, 12(8), 1045. https://doi.org/10.3390/brainsci12081045 (https://pubmed.ncbi.nlm.nih.gov/36009107/). 13. Dong, X., Tang, Y., Zhou, Y., & Feng, Z. (2023). Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review. Frontiers in neuroscience, 17, 1257378. https://doi.org/10.3389/fnins.2023.1257378 (https://pubmed.ncbi.nlm.nih.gov/37781261/). 14. Fan, W., Fan, Y., Liao, Z., & Yin, Y. (2023). Effect of Transcranial Direct Current Stimulation on Patients With Disorders of Consciousness: A Systematic Review and Meta-analysis. American journal of physical medicine & rehabilitation, 102(12), 1102–1110. https://doi.org/10.1097/PHM.0000000000002290 (https://pubmed.ncbi.nlm.nih.gov/37205736/). 15. Frazzitta, G., Zivi, I., Valsecchi, R., Bonini, S., Maffia, S., Molatore, K., Sebastianelli, L., Zarucchi, A., Matteri, D., Ercoli, G., Maestri, R., & Saltuari, L. (2016). Effectiveness of a Very Early Stepping Verticalization Protocol in Severe Acquired Brain Injured Patients: A Randomized Pilot Study in ICU. PloS one, 11(7), e0158030. https://doi.org/10.1371/journal.pone.0158030 (https://pubmed.ncbi.nlm.nih.gov/27447483/). 16. Jang, S. H., & Byun, D. H. (2022). A Review of Studies on the Role of Diffusion Tensor Magnetic Resonance Imaging Tractography in the Evaluation of the Fronto-Subcortical Circuit in Patients with Akinetic Mutism. Medical science monitor : international medical journal of experimental and clinical research, 28, e936251. https://doi.org/10.12659/MSM.936251 (https://pubmed.ncbi.nlm.nih.gov/35181647/). 17. Lombardi, F., Taricco, M., De Tanti, A., Telaro, E., & Liberati, A. (2002). Sensory stimulation for brain injured individuals in coma or vegetative state. The Cochrane database of systematic reviews, 2002(2), CD001427. https://doi.org/10.1002/14651858.CD001427 (https://pmc.ncbi.nlm.nih.gov/articles/PMC7045727/). 18. Magee, W. L., & O'Kelly, J. (2015). Music therapy with disorders of consciousness: current evidence and emergent evidence-based practice. Annals of the New York Academy of Sciences, 1337, 256–262. https://doi.org/10.1111/nyas.12633 (https://pubmed.ncbi.nlm.nih.gov/25773642/). 19. Mateo-Sierra, O., Gutiérrez, F.A., Fernández-Carballal, C., Pinilla, D., Mosqueira, B., Iza, B., & Carrillo, R.. (2005). Mutismo acinético relacionado con hidrocefalia y cirugía cerebelosa tratado con bromocriptina y efedrina: revisión fisiopatológica. Neurocirugía, 16(2), 134-141. (https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-14732005000200005). 20. Noé, E., Ferri, J., Colomer, C., Moliner, B., O'Valle, M., Ugart, P., Rodriguez, C., & Llorens, R. (2020). Feasibility, safety and efficacy of transauricular vagus nerve stimulation in a cohort of patients with disorders of consciousness. Brain stimulation, 13(2), 427–429. https://doi.org/10.1016/j.brs.2019.12.005 (https://pubmed.ncbi.nlm.nih.gov/31866491/). 21. Norwood, M. F., Lakhani, A., Watling, D. P., Marsh, C. H., & Zeeman, H. (2023). Efficacy of Multimodal Sensory Therapy in Adult Acquired Brain Injury: A Systematic Review. Neuropsychology review, 33(4), 693–713. https://doi.org/10.1007/s11065-022-09560-5 (https://pubmed.ncbi.nlm.nih.gov/36056243/). 22. O'Neal, C. M., Schroeder, L. N., Wells, A. A., Chen, S., Stephens, T. M., Glenn, C. A., & Conner, A. K. (2021). Patient Outcomes in Disorders of Consciousness Following Transcranial Magnetic Stimulation: A Systematic Review and Meta-Analysis of Individual Patient Data. Frontiers in neurology, 12, 694970. https://doi.org/10.3389/fneur.2021.694970 (https://pubmed.ncbi.nlm.nih.gov/34475848/). 23. Schiff, N. D., Giacino, J. T., Kalmar, K., Victor, J. D., Baker, K., Gerber, M., Fritz, B., Eisenberg, B., Biondi, T., O'Connor, J., Kobylarz, E. J., Farris, S., Machado, A., McCagg, C., Plum, F., Fins, J. J., & Rezai, A. R. (2007). Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature, 448(7153), 600–603. https://doi.org/10.1038/nature06041 (https://pubmed.ncbi.nlm.nih.gov/17671503/). 24. Schiff N. D. (2016). Central thalamic deep brain stimulation to support anterior forebrain mesocircuit function in the severely injured brain. Journal of neural transmission (Vienna, Austria : 1996), 123(7), 797–806. https://doi.org/10.1007/s00702-016-1547-0 (https://pubmed.ncbi.nlm.nih.gov/27113938/). 25. Schiff N. D. (2023). Mesocircuit mechanisms in the diagnosis and treatment of disorders of consciousness. Presse medicale (Paris, France : 1983), 52(2), 104161. https://doi.org/10.1016/j.lpm.2022.104161 (https://pubmed.ncbi.nlm.nih.gov/36563999/). 26. Shimojo, S., & Shams, L. (2001). Sensory modalities are not separate modalities: plasticity and interactions. Current opinion in neurobiology, 11(4), 505–509. https://doi.org/10.1016/s0959-4388(00)00241-5 (https://pubmed.ncbi.nlm.nih.gov/11502399/). 27. Stephens, T. M., Young, I. M., O'Neal, C. M., Dadario, N. B., Briggs, R. G., Teo, C., & Sughrue, M. E. (2021). Akinetic mutism reversed by inferior parietal lobule repetitive theta burst stimulation: Can we restore default mode network function for therapeutic benefit?. Brain and behavior, 11(8), e02180. https://doi.org/10.1002/brb3.2180 (https://pubmed.ncbi.nlm.nih.gov/34145791/). 28. Piedade, G. S., Assumpcao de Monaco, B., Guest, J. D., & Cordeiro, J. G. (2023). Review of spinal cord stimulation for disorders of consciousness. Current opinion in neurology, 36(6), 507–515. https://doi.org/10.1097/WCO.0000000000001222 (https://pubmed.ncbi.nlm.nih.gov/37889524/). 29. Rosenfelder, M. J., Helmschrott, V. C., Willacker, L., Einhäupl, B., Raiser, T. M., & Bender, A. (2023). Effect of robotic tilt table verticalization on recovery in patients with disorders of consciousness: a randomized controlled trial. Journal of neurology, 270(3), 1721–1734. https://doi.org/10.1007/s00415-022-11508-x (https://pubmed.ncbi.nlm.nih.gov/36536249/). 30. Thibaut, A., Bruno, M. A., Ledoux, D., Demertzi, A., & Laureys, S. (2014). tDCS in patients with disorders of consciousness: sham-controlled randomized double-blind study. Neurology, 82(13), 1112–1118. https://doi.org/10.1212/WNL.0000000000000260 (https://pubmed.ncbi.nlm.nih.gov/24574549/). 31. Visocchi, M., Della Pepa, G. M., Esposito, G., Tufo, T., Zhang, W., Li, S., & Zhong, J. (2011). Spinal cord stimulation and cerebral hemodynamics: updated mechanism and therapeutic implications. Stereotactic and functional neurosurgery, 89(5), 263–274. https://doi.org/10.1159/000329357 (https://pubmed.ncbi.nlm.nih.gov/21860253/). 32. Yang, Y., He, Q., Xia, X., Dang, Y., Chen, X., He, J., & Zhao, J. (2022). Long-term functional prognosis and related factors of spinal cord stimulation in patients with disorders of consciousness. CNS neuroscience & therapeutics, 28(8), 1249–1258. https://doi.org/10.1111/cns.13870 (https://pubmed.ncbi.nlm.nih.gov/35619213/). 33. Yang, Y., He, Q., Dang, Y., Xia, X., Xu, X., Chen, X., Zhao, J., & He, J. (2023). Long-term functional outcomes improved with deep brain stimulation in patients with disorders of consciousness. Stroke and vascular neurology, 8(5), 368–378. https://doi.org/10.1136/svn-2022-001998 (https://pubmed.ncbi.nlm.nih.gov/36882201/). 34. Yu, Y. T., Yang, Y., Wang, L. B., Fang, J. L., Chen, Y. Y., He, J. H., & Rong, P. J. (2017). Transcutaneous auricular vagus nerve stimulation in disorders of consciousness monitored by fMRI: The first case report. Brain stimulation, 10(2), 328–330. https://doi.org/10.1016/j.brs.2016.12.004 (https://pubmed.ncbi.nlm.nih.gov/28017322/). 35. Zhou, Y. F., Kang, J. W., Xiong, Q., Feng, Z., & Dong, X. Y. (2023). Transauricular vagus nerve stimulation for patients with disorders of consciousness: A randomized controlled clinical trial. Frontiers in neurology, 14, 1133893. https://doi.org/10.3389/fneur.2023.1133893 (https://pubmed.ncbi.nlm.nih.gov/36937511/). 36. Zhuang, Y., Yang, Y., Xu, L., Chen, X., Geng, X., Zhao, J., & He, J. (2022). Effects of short-term spinal cord stimulation on patients with prolonged disorder of consciousness: A pilot study. Frontiers in neurology, 13, 1026221. https://doi.org/10.3389/fneur.2022.1026221 (https://pubmed.ncbi.nlm.nih.gov/36313512/). 37. Zuo, J., Tao, Y., Liu, M., Feng, L., Yang, Y., & Liao, L. (2021). The effect of family-centered sensory and affective stimulation on comatose patients with traumatic brain injury: A systematic review and meta-analysis. International journal of nursing studies, 115, 103846. https://doi.org/10.1016/j.ijnurstu.2020.103846 (https://pubmed.ncbi.nlm.nih.gov/33485101/).

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n this episode of Conversations in Lung Cancer Research, A/Prof Tim Clay discusses the multidisciplinary management of CNS metastases in the context of thoracic cancers. Joined by Dr. Keryn Davidson, a consultant neurosurgeon, and A/Prof Fiona Hegi Johnson, a radiation oncologist, the discussion focuses on the nuances of treating patients with non-small cell lung cancer presenting with brain metastases. Key topics include the role of neurosurgery, decision-making for radiation therapy, evolving approaches for oncogene-driven cancer patients, management of radiation necrosis, and the complexities of treating small cell lung cancer and leptomeningeal disease.  This episode is sponsored by Pfizer.(00:00) Introduction and Acknowledgements(00:35) Meet the Experts(01:44) Neurosurgery in CNS Metastases(07:00) Radiation Therapy Insights(13:59) Oncogene-Driven Lung Cancer(25:14) Challenges in Small Cell Lung Cancer(29:56) Advanced Treatment Strategies(32:23) Future Directions and Conclusion

Ann Louise Gittleman welcomes Joe Wells—UNI KEY's behind-the-scenes partner in the development of Collagen 4+ and a seasoned entrepreneur with three decades in health and fitness. A former NFL player turned industry innovator, Joe founded Max Muscle and scaled it to nearly 200 franchise stores, launched Max Sports & Fitness magazine, helped develop more than 200 nutrition products, and was honored as Entrepreneur of the Year by the Academy of Bodybuilding, Fitness & Sports. In this fast, plain-English masterclass, Joe demystifies collagen (19 amino acids, grass-fed, hormone-free, animal-derived) and explains why most powders aren't complete proteins. Collagen 4+ fixes that by adding L-tryptophan—so your scoop behaves like a complete protein—then turns up results with vitamin C to drive collagen synthesis, hyaluronic acid (famous for holding up to 1,000× its weight in water) for skin hydration and joint comfort, and AstraGin®️ for up to 70% more collagen absorption! Clean and flavorless, it disappears into coffee, smoothies, or soups—making it a perfect way to boost your collagen levels for strength, skin, and recovery. The post Meet The Secret Genius Behind UNI KEY's Collagen 4+ first appeared on Ann Louise Gittleman, PhD, CNS.

On this podcast, I cover ciprofloxacin pharmacology. Ciprofloxacin is one of the most widely recognized fluoroquinolone antibiotics and has been on the market for decades. Because of its broad utility, it often comes up in practice, but it also carries significant adverse effect concerns and boxed warnings that pharmacists and prescribers need to keep in mind. From a pharmacology standpoint, ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for bacterial DNA replication, transcription, and repair. This action gives ciprofloxacin bactericidal activity against a variety of gram-negative organisms, including E. coli, Klebsiella, Enterobacter, and Pseudomonas aeruginosa. It also has some gram-positive activity, though it is generally not the best choice for strep infections. Ciprofloxacin comes in multiple dosage forms, including oral tablets, oral suspension, and intravenous formulations, which makes it flexible across care settings. I discuss the conversion of IV and PO formulations. Pharmacokinetics are important to consider. Ciprofloxacin is primarily renally eliminated, so dose adjustments are necessary in patients with impaired kidney function. Distribution into tissues is generally good, but it has limited activity in the lungs against Streptococcus pneumoniae, which is why it is not a first-line option for community-acquired pneumonia. Adverse effects are a major concern. The fluoroquinolone class carries multiple boxed warnings. Ciprofloxacin has been associated with tendon rupture, peripheral neuropathy, CNS effects such as agitation or seizures, and exacerbation of myasthenia gravis. More recent warnings include the risk for aortic aneurysm and hypoglycemia or hyperglycemia, particularly in older adults or those with comorbidities. On top of these boxed warnings, ciprofloxacin can also prolong the QT interval and cause GI upset. Drug interactions are another big factor in practice. Ciprofloxacin is a CYP1A2 inhibitor, which can raise levels of drugs like theophylline, tizanidine, and clozapine. It also interacts with polyvalent cations such as calcium, magnesium, iron, and aluminum, which can dramatically reduce its absorption—sometimes by more than 50%. This is a common reason for treatment failure if counseling isn't provided. From a dosing perspective, ciprofloxacin is usually given 250–750 mg orally twice daily or 400 mg IV every 8–12 hours depending on the indication and severity of infection. Renal dosing adjustments are needed as kidney function declines. In summary, ciprofloxacin is a powerful antibiotic when used appropriately. It remains an option for urinary tract infections, complicated intra-abdominal infections, and some cases of hospital-acquired pneumonia, but its use must be balanced with the potential for significant adverse effects and interactions. For pharmacists, educating patients on drug interactions, counseling about boxed warnings, and ensuring correct dosing in renal impairment are some of the most valuable interventions when ciprofloxacin shows up on a medication list.

On the Feast of Our Lady of Guadalupe, Bishop Mark Seitz, Chair of the Committee on Migration, issued a statement in solidarity with migrants and invited all people of faith to pray for those forced to move from their homes. Read the statement: On Feast of Our Lady of Guadalupe, U.S. Bishops' Migration Chairman Reaffirms Church's Solidarity with Immigrants. Pope Francis also celebrated Mass for the occasion on December 12, 2022. Watch the CNS video: Pope: Guadalupe's message of hope. Learn more about the U.S. bishops' Committee on Migration: https://www.usccb.org/committees/migration While praying on the Solemnity of the Immaculate Conception of the Blessed Virgin Mary, Pope Francis broke down while speaking of the suffering in Ukraine. Watch the CNS video: Pope weeps for Ukraine. On Gaudete Sunday, Pope Francis prayed for the children of Ukraine. Watch the CNS Video Pope: May Christmas bring hope to Ukrainians.

The working document for the Synod of Bishops in October was released by the Vatican on June 20th. The document will form the basis for the discernment and discussion for the participants of the first session of the XVI Ordinary General Assembly of the Synod of Bishops to be held in October 2023 in the Vatican. Read the CNS story (https://www.usccb.org/news/2023/synod-document-asks-how-increase-unity-participation-mission-outreach). Press release (https://www.usccb.org/news/2023/usccb-welcomes-release-instrumentum-laboris-first-session-xvi-ordinary-general-assembly). The Archdiocese of St. Louis held its second annual ‘Forgive Us Our Trespasses' Maafa and prayer service to remember enslaved persons and acknowledge the archdiocese's involvement with the institution of slavery. Read the story from the St. Louis Review (https://www.archstl.org/-forgive-us-our-trespasses-maafa-and-prayer-service-remembers-enslaved-persons-8740). Learn about the USCCB Subcommittee on African American Affairs (https://www.usccb.org/committees/african-american-affairs) and the Ad Hoc Committee Against Racism (https://www.usccb.org/committees/ad-hoc-committee-against-racism). Pope Francis blessed a four-foot-tall monstrance for the U.S. National Eucharistic Congress in 2024 and spoke about how at Mass that morning he was thinking about Jesus' great gift of himself in the Eucharist, a gift that nourishes and consoles believers. Read the CNS story. Learn more about the Eucharistic Revival at (https://www.eucharisticrevival.org/) Archbishop Christophe Pierre, Apostolic Nuncio to the United States, spoke with Catholic Current about the gifts and challenges of the Catholic Church in the United States.

Lauren Coyle, Launch Commissioning Editor, Bioconjugation Insights, speaks with Kerstin Hofer, Science and People Lead, Roche, about the evolving application of antibody-oligonucleotide conjugates in neurology. She highlights their design, delivery challenges across the blood–brain barrier, and potential to transform CNS diseases.

Released 2023.10.06 Pope Francis told the church's 21 new cardinals, including one born in the United States, that the key to evangelizing is to "cherish in our hearts the wonder and gratitude" of having heard the Gospel message and of knowing that they, like all Christians, still must grow in faith. Read the CNS story: Creating cardinals from 16 nations, pope asks them to join church 'symphony'. Watch the CNS video ”Cardinals for a Synodal Church”, an interview with Cardinal Prevost, and an interview with Cardinal Pierre. In Pope Francis' new document on the climate crisis, he urges everyone to "move beyond the mentality of appearing to be concerned" and to have "the courage needed to produce substantial changes." Catholic Current speaks with Metropolitan Archbishop Borys Gudziak, Chair of the Domestic Justice and Human Development Committee, about environmental concerns. Learn more about the USCCB's work to promote care for our common home at www.usccb.org/environment. Read the CNS Story: Pope, in document on climate crisis, criticizes science 'deniers.' Read Laudate Deum. Catholic Current speaks with Antonia Salzano Acutis, mother of Blessed Carlo Acutis who is patron of the National Eucharistic Revival. Learn about Eucharistic Miracles of the World – an initiative led by Carlo Acutis as a teenager. Pope Francis opened the assembly of the Synod of Bishops on October 4th, 2023, with a Mass in St. Peter's Square. Read the CNS story: Pope addresses fears around synod: 'Not a political gathering'. Watch videos from CNS Rome: Pope: The church has stopped to listen and Pope: Trust God, don't fear the synod. Learn more about the synod at https://www.usccb.org/synod and visit https://www.usccb.org/newsroom for the latest news on the Synod.

Released 2023.10.26 Pope Francis invited all people of faith to join him on October 27th for a day dedicated to prayer, fasting, and penance for peace and reconciliation in Israel and Gaza. Watch the CNS video: Pope: War is always a defeat. Read the letter from Cardinal Pierbattista Pizzaballa, Latin Patriarch of Jerusalem, to his entire diocese: https://www.lpj.org/posts/letter-to-the-entire-diocese.html October is Domestic Violence Awareness Month. Read the U.S. Bishops' pastoral letter, When I Call for Help: A Pastoral Response to Domestic Violence Against Women. Catholics For Family Peace Education and Research on Domestic Abuse provides education, resources, and research that help Catholics promote peace within families and to recognize and respond with compassion to domestic abuse. Visit https://www.catholicsforfamilypeace.org/ to learn more and download resources. Archbishop Timothy P. Broglio, president of the U.S. Conference of Catholic Bishops, has been participating in the assembly of the Synod of Bishops and shared with CNS some of his thoughts about the monthlong experience. Read “USCCB president talks about his synod experience.” Participants in the Synod on Synodality have approved a Letter to the People of God giving thanks for their experience, detailing the work of the past few weeks, and expressing the hope that in the coming months, everyone will be able to "concretely participate in the dynamism of missionary communion indicated by the word 'synod.'"

Released 2023.10.19 Pope Francis invited all people of faith to join him on October 27th for a day dedicated to prayer, fasting, and penance for peace and reconciliation in Israel and Gaza. Watch the CNS video: https://www.youtube.com/watch?v=XiuzrjveGv4 The bishops of the United States launched a mental health campaign on October 10th, Mental Health Day. It is a time when people from many nations are seeking to raise awareness and remove the stigma around issues concerning mental health. The bishops invite people to pray a special Novena for Mental Health. Watch : https://www.youtube.com/watch?v=pR9s8jAcqik As the Synod on Synodality continues in Rome, Catholic News Service has spoken with participants about their experiences: • WATCH: At the synod on synodality, Cardinal Tobin said a more inclusive church would better spread the Gospel: https://www.youtube.com/watch?v=pK7nKJYa88g • WATCH: Cardinal Cupich said the synod on synodality is advancing the place of women in the church: https://www.youtube.com/watch?v=MWrbp9v5tYI • WATCH: Synod leaders respond to hopes and fears about their work: https://www.youtube.com/watch?v=yvTXUSmP3Ho

Featuring an interview with Dr Sarah Sammons, including the following topics: Development of brain metastases in patients with HER2-positive and HER2-negative breast cancer (0:00) Local therapy approaches for the treatment of brain metastases (8:23) Treatment options for patients with HER2-positive breast cancer and CNS-only disease progression (16:36) Clinical presentation of leptomeningeal disease; management of functional sequelae associated with brain metastases (19:07) Investigational agents for the treatment of brain metastases in HER2-positive breast cancer (25:01) Case: A 65-year-old woman with ER-negative, HER2-positive metastatic breast cancer (mBC) develops a single 6-mm brain metastasis after 4 years of maintenance trastuzumab/pertuzumab (27:38) Screening for brain metastases; radiation necrosis as a side effect of radiation therapy (31:00) Case: A 39-year-old woman with ER-negative, HER2-positive mBC develops 7 new brain metastases 6 months into treatment with a taxane, trastuzumab and pertuzumab (34:30) CME information and select publications

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. While the development of targeted therapies has improved outcomes for many patients with EGFR-mutated NSCLC, those with rare EGFR variants often face limited treatment options, especially when the disease involves the central nervous system (CNS). A recent research paper, titled “Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib” published in Volume 16 of Oncotarget, describes a patient with NSCLC harboring two uncommon EGFR mutations—G719A and A289V—who experienced a prolonged and clinically significant response to amivantamab monotherapy, after prior treatments had failed. Full blog - https://www.oncotarget.org/2025/08/26/amivantamab-monotherapy-in-rare-egfr-mutated-advanced-nsclc/ Paper DOI - https://doi.org/10.18632/oncotarget.28730 Correspondence to - Young Kwang Chae - young.chae@northwestern.edu Video short - https://www.youtube.com/watch?v=UEiCz834a8c Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28730 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, amivantamab, monotherapy, rare EGFR mutation, NSCLC, leptomeningeal disease About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Today's guest is Boo Schexnayder. Irving “Boo” Schexnayder is a world-class coach and consultant with over 44 years of experience in track and field. Renowned for producing 26 NCAA Champions and 8 Olympic/World Championship medalists, he co-founded Schexnayder Athletic Consulting and founded the Track and Field Academy. A former LSU coach and USA Track and Field leader, Boo's expertise in biomechanics and training design extends to multiple sports, making him a sought-after mentor worldwide. It's common to think that, as time moves forward in any discipline, that discipline becomes better. What seems to define much of athletic performance and sport itself is that outputs become the priority while movement quality and literacy become watered down. On today's podcast, Boo gives wisdom into the process of comprehensive athletic development by leaning into general strength and movement training. He goes over his movement batteries, scramble circuits, training diversity, and tempo sprints. Boo also gives his take on the use of supramaximal eccentrics, covers hamstring injury prevention strategies, and discusses his sprint-float-sprint protocols, alongside a sea of further training wisdom. Today's episode is brought to you by Hammer Strength and LILA Exogen wearable resistance. Use the code “justfly25” for 25% off any Lila Exogen wearable resistance training, including the popular Exogen Calf Sleeves. For this offer, head to Lilateam.com View more podcast episodes at the podcast homepage. (https://www.just-fly-sports.com/podcast-home/) Timestamps 1:25 – The evolution of general strength since the 90s 23:12 – General strength across track and team sports 28:47 – Adding multi-directional work for linear athletes 37:18 – Managing tempo volume for higher intensity 42:50 – Polarized training over middle-ground tempo 44:14 – Using tempo for restoration, not breakdown 47:24 – Short sprints on low days to cap tissue load 48:50 – Eccentric overload within a balanced profile 57:08 – Sprinting and mobility for hamstring resilience 1:12:02 – Setting fly-float-fly zones by max velocity 1:12:52 – Coaching lessons that shaped training design Actionable Takeaways 1:25 – The evolution of general strength since the 90s Boo explains that early “general strength” meant broad, circuit-based work (med balls, hurdle mobility, bodyweight drills), and over time, coaches either overcomplicated it or lost sight of its role. What to try: Keep general strength simple—circuits that are easy to teach, scalable, and repeatable. Don't let weight room complexity replace basic movement skill. Revisit older methods (hurdle mobility, med ball throws) that build coordination without heavy stress. 28:47 – Adding multi-directional work for linear athletes Even linear sprinters benefit from “scramble” circuits and agility-oriented elements. Boo stresses that multi-directional tasks improve coordination, robustness, and adaptability. What to try: Sprinkle in agility, shuffles, and lateral bounds for athletes who train mostly linear. Build circuits that force athletes to problem-solve movement, not just run straight lines. Think “movement quality first”—variety pays off long term. 37:18 – Managing tempo volume for higher intensity Boo highlights that loading too much tempo work flattens intensity. Athletes need tempo in the right amount—enough for conditioning, not so much that it dulls speed. What to try: Keep tempo volumes moderate so athletes can still sprint fast on quality days. Use tempo as restoration or rhythm training, not just mileage. Remember: more work doesn't equal better adaptation—protect intensity. 47:24 – Short sprints on low days to cap tissue load Boo explains that short 10m sprints can safely live on “low” days—they maintain speed exposure without frying the system. What to try: Program 2–3 sets of short accelerations on low CNS days.

Lee Carroll joins The First Lady of Nutrition for a fascinating deep dive into the amazing world of functional mushrooms. Lee is a distinguished medical herbalist, innovator, speaker, educator, and mentor to health professionals worldwide. Ann Louise and Lee cover everything from mushroom coffee vs. supplements to why mushrooms deliver nutrients you won't find elsewhere. Surprising fact: humans and fungi share 30% DNA! The conversation spotlights ergothioneine—a unique antioxidant concentrated in red blood cells, the eyes, and the liver that Lee believes is poised to become the next big discovery in health circles. You'll learn where this compound is most concentrated (Golden Oyster leads the pack; Lion's Mane and Shiitake are other strong sources). In addition, you'll be privy to not only the specific amounts of these exclusive nutrients, but also why researchers are hard at work developing a test that may flag neurological risk years earlier. Lee also offers a fresh lens on why women face more autoimmunity disorders than men and how mushroom nutrients may support immune balance. These two titans of health touch on product quality, cancer-care conversations, and Lee's Top 5 mushroom picks.  Curious which mushrooms to sip, stack, or sauté? Press play—and start a smarter mushroom routine. Learn more about Lee at herbameditari.com or realmushrooms.com. The post Ergothioneine: The Most Important Nutrient You Have Never Heard Of! – Episode 201: Lee Carroll first appeared on Ann Louise Gittleman, PhD, CNS.

With more than 30 years of experience spanning global pharma, emerging biotech, and the evolving field of personalized medicine, Bracken Senior Partner Dr. David Krause has helped shape the clinical and regulatory landscape across therapeutic areas—from vaccines and anti-infectives to neuropsychiatry and oncology.As a physician, former Chief Medical Officer, and trusted development advisor, David brings a uniquely humanist and interdisciplinary lens to the science and strategy of drug development.In this episode of Fractals: Life Science Conversations, David and host Colin Miller explore:How leadership style must evolve from large pharma to small biotech—and why succession planning matters more than you think.The future of personalized medicine in CNS and oncology—and how AI, genetics, and neuroplasticity are reshaping treatment paradigms.What pharma can learn from infectious disease: why psychiatry is just now catching up to decades-old precision strategies in anti-infectives.Reflections on partnering with the FDA, lessons learned from vaccine development, and the clinical promise of psychedelics.Listen to Fractals on your favorite podcast platform, and contact Bracken to learn how our cross-functional teams can support your clinical, medical, and regulatory strategy.

Are you someone trying to manage perimenopause or menopause while ALSO dealing with frustrating chronic illness symptoms?  In this episode, I'm joined by the brilliant Dr. Jessica Drummond—clinical nutritionist, physical therapist, and board-certified health coach—who has spent over 25 years helping women navigate the tangled intersection of hormones, immune health, and chronic illness.  We dive into what to do when your perimenopause symptoms blur into post-viral syndromes, autoimmune flares, chronic fatigue, and more.  Dr. Jessica shares how to discover when there's something deeper going on—and how to uncover the real root causes of your symptoms. Plus, she offers practical, science-backed strategies to support your hormones, immune system, and energy levels, even if you've felt stuck for years.  Tune in to feel empowered AND educated on your midlife symptoms!  Jessica Drummond, DCN, CNS, PT, NBC-HWC  Dr. Jessica Drummond is the founder and CEO of The Integrative Women's Health Institute. She has 25 years of clinical experience as a licensed physical therapist, licensed clinical nutritionist, and board-certified health coach working with women who battle chronic pain, illnesses, and post-viral syndromes. Her integrative approach helps her patients overcome hormonal imbalances and chronic pain conditions. Dr. Drummond was educated at the University of Virginia, Emory University, Duke Integrative Medicine, and Maryland University of Integrative Health. IN THIS EPISODE Dr. Drummond's journey with chronic illness in perimenopause How viral illnesses like COVID impact hormones, and particularly the health of middle-aged women  How Dr. Drummond's time in Europe impacted her health Distinguishing illness symptoms from perimenopause symptoms  Non-negotiable habits for improving midlife health and energy How to prioritize yourself in perimenopause and menopause  QUOTES “85% of women in perimenopause also have other chronic illnesses; endometriosis, autoimmune disease, pain syndromes, PCOS, chronic concussions, diabetes…” “I always say this is kind of the only time in life you get to slow down for a minute. I highly suggest hiring a coach… You probably never had this opportunity to lead from your desires.”  “You're in perimenopause. You have a lot going on physiologically. You have a lot going on in your career, your parenting, but also your decisions aren't exactly your own. I feel like for me, they've always been integrated with at least my husband and my kids… so you also have to deepen your skillset of relationships, of listening, of prioritizing people's desires and needs.” RESOURCES MENTIONED Integrative Women's Health Institute Website Dr. Jessica Drummond's Free workshop for women's health and wellness professionals Integrative Women's Health Institute on Instagram  Pre-order my new book: The Perimenopause Revolution  RELATED EPISODES  591: Post Viral Syndromes, Your Immune System, and Your Hormones in Midlife with Dr. Jessica Drummond#648: This Changes Everything: The Perimenopause Revolution Every Woman Needs Now#392: How to Live with a Chronic Illness and Ways to Bring Awareness to Endometriosis and Autoimmune Conditions with Jenneh Rishe#609: Non-Negotiable Advice I Would Give My Early Perimenopausal Self

Join me for a conversation with four fantastic panelists about nuclear safety and security issues brought on by Russia's full-scale invasion of Ukraine, and more broadly on the state of nuclear security globally during this era of dramatic change.This program was made possible by the Ukrainian Platform for Contemporary China and the Center for Slavic, Eurasian, and East European Studies at the University of North Carolina Chapel Hill.Nickolas Roth is Senior Director for Nuclear Materials Security at the Nuclear Threat Initiative (NTI). Nickolas works at the intersection of arms control, risk reduction, and institutional resilience, and previously directed nuclear security work at the Stimson Center and contributed to Harvard's Project on Managing the Atom.Mariana Budjeryn is a Senior Research Associate with Managing the Atom at Harvard's Belfer Center and author of Inheriting the Bomb, a definitive study of Ukraine's post-Soviet disarmament and the limits of the Budapest Memorandum. Her scholarship grounds today's debates about guarantees, coercion, and nuclear restraint.Pan Yanliang is a Research Associate at the James Martin Center for Nonproliferation Studies (CNS). He studies the Russian and Chinese nuclear industries and the nuclear fuel cycle, and works on CNS engagement with Chinese counterparts—giving him a distinctive cross-regional vantage.Lily Wojtowicz is a Research Fellow at the Hertie School (Berlin) and a USIP–Minerva Peace & Security Scholar, whose work focuses on extended deterrence credibility, European security, and alliance adaptation under great-power rivalry.5:19 - The Gap Between Coercive Rhetoric and First-use Thresholds11:26 - The Implication of Ukraine's allies regarding weapons 17:26 - Golden Dome21:30 - China's Position on Nuclear Weapons29:25 - How Belarus Altered European Debates 31:13 - Civilian Nuclear Power 38:32 - North Korea's Support for Russia40:59 - Beijing on NATO and Asian Security43:09 - Europe's Reaction to Nuclear Risk45:44 - Nuclear Risk in the Russia-Ukraine War52:56 - Trump's Impact on Kremlin Nuclear Thinking1:01:52 - US-China Nuclear Relations1:04:49 - Ukraine's Nuclear DisarmamentSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The role of neuronal influences on cancer pathogenesis and progression is increasingly appreciated in the nervous system. Neurons have been shown to enhance the proliferation and migration of gliomas, a glial-derived tumor of the CNS, via diffusible paracrine factors or synaptic inputs onto tumor cells. In glioblastomas, a highly aggressive glioma, mostly glutamatergic inputs have been identified. While the potential for glioblastomas to receive projections from neurons of other neurotransmitter subtypes, such as from cholinergic neurons, has recently been discovered in xenotransplantation models, whether synapses can form between human cholinergic neurons and glioblastoma cells and consequences of these inputs and other non-synaptic mechanisms are still unknown.   Human induced pluripotent stem cell-based models have been emerging as a powerful platform for studying human-specific disease mechanisms. Today's guests developed a co-culture model for the study of neuron-tumor interactions by combining patient derived glioblastoma organoids and hiPSC-derived cholinergic neurons. They will discuss their recent findings and what it means for understanding and potentially treating a tumor for which there is no known cure. GuestsGuo-li Ming, MD, PhD, Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of PennsylvaniaHongjun Song, PhD, Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania Yusha Sun, Neuroscience Graduate Group, Perelman School of Medicine, University of PennsylvaniaHostJanet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner FoundationSupporting ContentPaper link:  Cholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model, Stem Cell ReportsAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Senior Marketing ManagerJack Mosher, Scientific DirectorHunter Reed, Senior Marketing Coordinator

Hoje é sábado e temos um resumo especial dos pontos mais importantes da semana, em que discutimos sobre "História das mulheres na política brasileira”Contamos com as participações de:Laila Talita, graduanda em licenciatura em história pela Universidade Federal de Alagoas.Maria das Graças de Jesus Xavier, especialista em direitos humanos e coordenadora da União Nacional por Moradia Popular (UNMP).Fernanda Magno, Psicóloga e Presidenta do CNS de Saúde.

Unlike the adjuvant space, treatment of advanced clear cell renal cell cancer has been a success story potentially only surpassed by advanced melanoma. What was once a horrific and quickly fatal disease, with a predilection for the CNS and significant bleeding risk has become significantly less so. In this episode, Josh and Michael explore the studies that have made it happen.Studies discussed in this episodeCLEARCheckmate 214Checkmate 9ERFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.

In this episode, The First Lady of Nutrition welcomes Dr. Noel Baker, a respected functional medicine practitioner and one of the foremost protégés of Dr. Theodore Baroody, author of the groundbreaking book, The Hiatal Hernia Syndrome: The Mother of All Illnesses. Together, they explore a little-understood health issue—a hiatal hernia, which is essentially a misalignment of the stomach that can trigger a ripple effect of symptoms throughout the body. Ann Louise speaks from experience, having personally worked with Dr. Baker and experienced the healing process firsthand. A hiatal hernia is more than just a mechanical issue or a cause of common indigestion. It can be the hidden source behind a wide array of symptoms that many people—and their doctors—struggle to explain. This can include alarming symptoms that mimic heart attacks, a hijacked fight-or-flight response, disrupted vagus nerve function, trouble taking a deep breath and swallowing, plus a domino effect of stress-related imbalances throughout the body including anxiety. Listeners will also gain insight into the importance of the “alpha state,” the role of neurofeedback in restoring calm and nervous system balance, and how holistic practices like grounding, yoga, stretching—and even an unconventional method known as the “stomach egg”—can play a powerful role in the healing process. To connect with Dr. Noel Baker and his team, visit PureFunctionalMedicine.com. The post Hiatal Hernia: The Mother of All Illnesses – Episode 200: Dr. Noel Baker first appeared on Ann Louise Gittleman, PhD, CNS.

What is the role of a Clinical Nurse Specialist (CNS) in the ICU? How did Lynette LaBine, MSN, RN, CNS, CCRN leverage her CNS role to win buy-in and guide her team to become an Awake and Walking ICU? Lynette shares with us how consulting and training services opened the doors for her to fully lead the revolution in her ICU. Listen and watch Lynette's RN colleagues HERE and rehab colleagues HERE! Get your CE credit for this episode and all learning you do here!Want to bring the revolution to your ICU? Check out www.DaytonICUConsulting.com

L-Glutamine stands as one of the most powerful amino acids for optimizing gut health, muscle function, immune and brain health. It's a common solution for leaky gut, but overall can enhance the improvement of other therapies. In this episode, I'll dive into the benefits of l-glutamine, the best food sources, and effective protocols for different conditions.    ✅ Start healing with us! Learn more about our virtual clinic:https://drruscio.com/virtual-clinic/

In this episode of The Sunday BBQ, Kevin Hornsby is joined by Anthony Tennyson, CEO of Solvonis Therapeutics plc (LSE: SVNS), to discuss the Company's latest progress across its mental health and addiction treatment pipeline. Anthony outlines the £1 million investment from key shareholders to accelerate Solvonis' AI-driven CNS drug discovery programme, as well as the initiation of pivotal translational studies for SVN‑002 — a novel treatment for Alcohol Use Disorder — ahead of a Phase 2b trial in the US. We also explore the company's strategic use of the FDA's 505(b)(2) pathway and why its differentiated pipeline continues to attract attention in the neuropsychiatry space. Disclaimer & Declaration of Interest This podcast may contain paid promotions, including but not limited to sponsorships, endorsements, or affiliate partnerships. The information, investment views, and recommendations provided are for general informational purposes only and should not be construed as a solicitation to buy or sell any financial products related to the companies discussed. Any opinions or comments are made to the best of the knowledge and belief of the commentators; however, no responsibility is accepted for actions based on such opinions or comments. The commentators may or may not hold investments in the companies under discussion. Listeners are encouraged to perform their own research and consult with a licensed professional before making any financial decisions based on the content of this podcast. 

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain, practicing community oncologists, share their key takeaways from a session on NTRK Fusion Positive Solid Malignancies, they moderated during a satellite event at ASCO 2025 in partnership with Medscape Global Oncology. Join us as we discuss: •⁠  ⁠The prevalence of NTRK fusions in various cancers and why community oncologists should be aware of them. •⁠  ⁠The importance of comprehensive next-generation sequencing (NGS) for detecting these fusions across diverse histologies. •⁠  ⁠Available treatment options, including first-generation NTRK inhibitors like larotrectinib and entrectinib, and their efficacy in improving overall and progression-free survival. •⁠  ⁠Insights into the CNS activity of these treatments and the common side effects patients may experience. •⁠  ⁠Special considerations for pediatric patients, including formulation challenges and the potential for re-challenging with NTRK inhibitors. Don't forget to check out the full accredited enduring program by Medscape Global Oncology linked below, and earn your CME credit.  https://www.medscape.org/viewarticle/1002679?src=acdmpart_onc-brothers_1002679  Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ #entrectinib #larotrectinib #repotrectinib

On episode 523 of The Nurse Keith Show nursing and healthcare career podcast, Keith interviews author, nursing educator, and researcher Dr. Ruth Wittmann-Price, PhD, RN, CNS, CNE, CNEcl, CHSE, ANEF, FAAN. In the course of their conversation, Keith and Dr. Wittmann-Price discuss the importance and impact of competency-based education in nursing. Dr. Wittmann-Price also reflects on her storied career, and her perceptions and experiences as a highly accomplished nurse academician and writer. Ruth A. Wittmann-Price, PhD, RN, CNS, CNE, CNEcl, CHSE, ANEF, FAAN, is Dean of the W. Cary Edwards School of Nursing and Health Professionals at Thomas Edison State University in Trenton, NJ. Ruth has been an obstetrical/women's health nurse for 47 years. Dr. Wittmann-Price received her AAS and BSN degrees from Felician College, Lodi, New Jersey, and her MS as a perinatal clinical nurse specialist (CNS) from Columbia University, New York, New York. She completed her PhD in nursing at Widener University, Chester, Pennsylvania, and received the Dean's Award for Excellence. Ruth developed a mid-range nursing theory, “Emancipated Decision-Making in Women's Health Care,” and has tested her theory in four research studies. International researchers are currently using her theory as the foundation for their studies. Her theory is being used by researchers at the University of Limpopo, South Africa, in their campaign, “Finding Solutions for Africa,” which helps women and children. Dr. Wittmann-Price has taught all levels of nursing students over the past 30 years and has completed international service-learning trips. She has coedited or authored 16 books, contributed many chapters, and written numerous articles. She has presented her research regionally, nationally, and internationally. Dr. Wittmann-Price was inducted into the National League for Nursing Academy of Nurse Educator Fellows in 2013 and became a fellow in the American Academy of Nursing in October 2015. This episode of the Nurse Keith Show is brought to you in collaboration with Springer Publishing, who have been delivering award-winning healthcare education and exam prep materials focused on nursing, behavioral health, and the health sciences for more than 70 years. We thank Springer Publishing for their support. Links: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fast Facts About Competency-Based Education in Nursing: How to Teach Competency Mastery Certified Nurse Educator Review, 4th Edition Springer Publishing Contact Nurse Keith about holistic career coaching to elevate your nursing and healthcare career at ⁠⁠⁠⁠⁠⁠⁠NurseKeith.com⁠⁠⁠⁠⁠⁠⁠. Keith also offers services as a motivational and keynote speaker and freelance nurse writer. You can always find Keith on⁠⁠⁠⁠⁠⁠⁠ LinkedIn⁠⁠⁠⁠⁠⁠⁠. Are you looking for a novel way to empower your career and move forward in life? Keith's wife, Shada McKenzie, is a gifted astrologer and reader of the tarot who combines ancient and modern techniques to provide valuable insights into your motivations, aspirations, and life trajectory, and she offers listeners of The Nurse Keith Show a 10% discount on their first consultation. Contact Shada at ⁠⁠⁠⁠⁠⁠⁠TheCircelandtheDot.com ⁠⁠⁠⁠⁠⁠⁠or shada@thecircleandthedot.com.

Program notes:0:40 Human Phenotype project1:43 Metabolomics2:42 25 year follow up3:43 Two control groups4:00 CBT via telehealth or online5:00 2000 people with chronic pain6:00 Completion rate for videos lower6:50 RNA analysis in cancer molecular diagnostics7:50 4.8% failure rate8:50 CNS or blood cancers primarily9:25 Middle age exposure to air pollution and later cognition10:25 Poorer processing speed earlier in life11:58 End

In this episode, we are joined by Bryce Mooney and Dr. Sam Attanasio. Bryce (@brycemooneygolf) and Sam (@drsamattanasio) are co-founders of Speed Toad @speedtoad.---Follow us: Twitter - @TournamentCode Instagram - @thetournamentcode YouTube - The Tournament Code Hosted by: Cooper Collins (@coopercollins99), Jack Bergstrom (@Jack_Bergstrom), Daniel Hamrin (@DanielHamrin)Sponsored by: https://puttviewbooks.com/---(01:30) - PuttView Books opening tee shot(02:30) - background of Speed Toad(07:18) - real effects of Speed Toad(14:09) - comparison of speed implements(19:20) - strong vs. fast(26:12) - working out and swinging fast(35:14) - overspeed training(40:13) - how they got into long drive(50:01) - measuring CNS status

Asenapine is an atypical antipsychotic that acts as an antagonist at multiple receptors, including dopamine D2 and serotonin 5-HT2A, contributing to its antipsychotic and mood-stabilizing effects. Adverse effects of asenapine include somnolence, dizziness, and extrapyramidal symptoms. Because asenapine is significantly metabolized by CYP1A2, inhibitors or inducers of these enzymes can affect its plasma concentrations. Co-administration with other CNS depressants may increase the risk of sedation and impaired cognitive or motor function. Asenapine can prolong the QT interval, so caution is advised when used with other medications that affect cardiac conduction.

The First Lady of Nutrition spotlights environmental toxins expert Lara Adler. Adler is a globally recognized Environmental Health Educator who has trained thousands of practitioners to identify and address hidden toxic exposures impacting chronic health. Together, Ann Louise and Lara explore the unexpected ways chemicals in our everyday environment are sabotaging our health—and our waistlines. From hidden toxins in cookware, food packaging, and personal care products to unexpected offenders like candles, perfumes, and even your mattress, no topic is off-limits. You'll learn why the kitchen is frequently a chemical hotspot in the home, how “obesogens” may be fueling weight gain without you even consuming extra calories, and what to watch for in your bedroom, bathroom, and beyond. They even dive into the potential risks of candles, incense, tattoos, and whether essential oils are truly safe. Most importantly, Lara shares practical, doable swaps to reduce your toxic load without turning your life upside down.  Visit laraadler.com to learn more. The post How Common Household Chemicals are Disrupting Hormones, Weight & Wellbeing – Episode 199: Lara Adler first appeared on Ann Louise Gittleman, PhD, CNS.

In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the July 2025 Emergency Medicine Practice article, Emergency Department Management of Status Epilepticus in Pediatric PatientsIntroductionWelcome and brief overview of the episodePromotion of EB Medicine's $1 for 7-day trial offerWhy Pediatric Status Epilepticus MattersSeizures make up ~1% of ED visits and ~3% of EMS callsHigh-risk and high-stakes condition requiring rapid actionStatus epilepticus now defined as ≥5 minutes of seizure activityILAE's T1 and T2 timelines help define when to treat and when damage beginsCommon CausesTop contributors:Fever/infectionStructural CNS abnormalitiesToxic ingestionsGenetic/metabolic disordersAdditional factors by age:Infants: febrile seizures, chromosomal issues, traumaSchool-age: autoimmune disordersAdolescents: eclampsia, hypertension, functional disordersAlways consider non-accidental traumaPrehospital CareIM midazolam is effective and recommended (RAMPART trial)Other options: intranasal, rectal, or IV benzodiazepinesEarly benzodiazepine administration improves outcomesImportance of airway support, glucose check, and EMS flexibilityParent-administered home meds (e.g. rectal diazepam) can be helpfulED Evaluation and Initial ManagementPrioritize ABCs: Airway, Breathing, Circulation, ConsciousnessUse end-tidal CO₂ to monitor ventilation if availablePoint-of-care glucose is essentialLabs: CMP, Mg, Phos, lactate, drug levels, pregnancy test (when indicated)Imaging: Head CT if concern for trauma, shunt malfunction, or focal signsCase examples highlight pitfalls and diagnostic delaysFirst-Line TreatmentBenzodiazepines remain the cornerstoneLorazepam preferred IV agent (0.1 mg/kg)Midazolam preferred if no IV access (IN, IM, or IO)Diazepam is also effective, especially rectallyBe mindful of respiratory depression and the need for airway controlSecond- and Third-Line TherapiesBased on ESETT trial:Levetiracetam, fosphenytoin, and valproate have similar efficacyLevetiracetam favored for safety and ease of useFosphenytoin may be avoided in trauma or toxicityValproate not recommended in mitochondrial diseasePhenobarbital reserved for refractory cases onlyRefractory Status EpilepticusDefinition: persistent seizures despite first- and second-line agentsRequires sedation and likely intubationInfusion options:Midazolam (preferred for flexibility)Propofol (short-term use only due to risk of infusion syndrome)Pentobarbital (rare, ICU-level care)Need for continuous EEG to assess seizure activitySpecial ScenariosNeonates:Watch for subtle signs (lip smacking, bicycling, tongue thrusting)Broad differential includes asphyxia, infection, metabolic errorsFebrile Status Epilepticus:Higher risk of CNS infections, especially if unvaccinatedConsider lumbar puncture if indicatedElectrolyte/Metabolic Triggers:Treat hypoglycemia, hyponatremia, and hypocalcemia directlyUse 3% saline or dextrose as appropriateDisposition and Discharge ConsiderationsMany children will require ICU-level careSome known epilepsy patients may go home if back to baselineEnsure rescue medications are up to date (rectal/intranasal benzos)Consider “clonazepam bridge” for short-term seizure preventionCollaborate with neurology for medication adjustment and follow-upFinal ThoughtsKeep treatment tables and dosing references accessibleEarly, aggressive treatment can prevent long-term harmEpisode closes with gratitude to article authors and a reminder to visit EBMedicine.netEmergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

Dr. Pallawi Torka of Memorial Sloan Kettering Cancer Center joins to share highlights from ASCO and EHA 2025 on the evolving landscape of B-cell lymphomas, including Hodgkin lymphoma, diffuse large B-cell lymphoma (DLBCL), and follicular lymphoma. She offers in-depth insights on the STARGLO study and its recent ODAC review, the POLARGO trial, a rare T-cell leukemia (T-LGL) study, and new data supporting nivolumab-AVD in frontline Hodgkin lymphoma. Additional discussion includes the inMIND trial for follicular lymphoma, the growing role of ctDNA in managing DLBCL, advances in CAR-T cell therapy for CNS lymphoma, and how she is adapting treatment strategies based on favorable vs. unfavorable disease features. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

We love to hear from our listeners. Send us a message.On this episode of Cell & Gene: The Podcast, Host Erin Harris talks to Ralf Schmid, Ph.D., Associate Director of Preclinical Research at Novartis Biomedical Research, about the evolving use of large animal models in gene therapy development. Dr. Schmid discusses the current reliance on non-human primates (NHPs), their growing logistical and ethical challenges, and the emerging interest in alternatives like genetically engineered pigs and sheep. He outlines key considerations around safety, biodistribution, and immunogenicity that still necessitate large-animal testin —particularly for CNS-targeted AAV therapies — and emphasizes the need for thoughtful study design, responsible sourcing, and diversification in model systems. Dr. Schmid also previews his participation in the upcoming Next Generation Gene Therapy Vectors Summit and reflects on the future of preclinical safety testing in a landscape aiming to balance innovation, rigor, and compassion.Subscribe to the podcast!Apple | Spotify | YouTube

In this episode, Duane Schulthess is joined by Sam Rasty, Chief Business Officer at Sensorium Therapeutics, Steve Potts, Chair of the Drug Development Council at the International Cancer Advocacy Network, and Joe Hammang, neuroscientist and US Business Director at Vital Transformation, to discuss how U.S. health policy is reshaping neuroscience innovation, investment priorities, and patient access. Key Topics:- Investment and R&D Strategy Shifts: Explore how the Inflation Reduction Act’s pricing controls and Medicare negotiations change venture capital allocation and steer neuroscience pipelines.- Patient Advocacy and Access Barriers: Guests discuss how formulary rules, generic-first requirements, and uneven advocacy across diseases affect drug adoption and innovation incentives.- Neuroscience Development Hurdles: The discussion highlights how social stigma around psychiatric conditions, fragmented orphan-disease incentives, and small-molecule exclusivity gaps slow CNS drug progress.- Legislative Fix Imperatives: Contributors outline proposed solutions such as the EPIC Act and expanded orphan-designation policies aimed at restoring balanced incentives for novel therapies.- Ecosystem Collaboration: The conversation covers the essential partnership between NIH funding, biotech startups, and pharmaceutical companies in advancing drugs from discovery to patients. This episode examines the policy, economic, and social factors influencing neuroscience drug discovery and the importance of communicating biotech’s value. It also highlights the need to improve the biotech narrative so that policymakers and the public understand its contributions. It is essential listening for industry leaders, investors, policymakers, and patient advocates seeking insight into innovation challenges and solutions.See omnystudio.com/listener for privacy information.

Astellas is doubling down on gene therapy while others retreat. Richard Wilson, SVP at Astellas Gene Therapies, joins In Vivo to discuss why the company believes AAV technology will transform medicine despite current industry headwinds.

In this Live in the Tribe episode, I tackle how to balance cardio during a bulk, why most lifters struggle with chest development, and how to match tempo and exercise selection for better hypertrophy results. I share hard-earned lessons from my own aggressive bulk, why mobility is the missing link in chest training, and how inconsistent cardio can sabotage your muscle gain goals.You'll also hear coaching insights on training splits, CNS adaptation, and how to know when it's time to switch phases or tweak your approach. Whether you're bulking, plateaued, or just tired of spinning your wheels, this episode delivers the real coaching no one else is giving you.And if you want to transform your body, message me the word "Coaching" on IG at Tomthetrainerfitness, Facebook at Tom Trainer Mouland, or book a Free Strategy Call

Join integrative oncologist Dr. Michael Karlfeldt, ND as he sits down with The First Lady of Nutrition to explore what is really driving today's exploding cancer epidemic. Dr. Karlfeldt shares how cancer behaves like a wildfire and why stopping it requires more than just one strategy. Ann Louise and Dr. Karlfeldt dive into a discussion that ranges from diagnostic tests like thermography, live blood analysis, and the Nagalase and Gallery Tests to integrative treatments like IV therapies, anti-cancer diets, herbal protocols, and lifestyle changes. Dr. Karlfeldt lays out a comprehensive approach that both supports and challenges conventional care.  Learn how to choose the best treatment for you, bolster conventional therapies, and understand why the tumor isn't the disease, it's just the symptom. Most importantly, discover the common characteristics of those who thrive after a cancer diagnosis—and why letting go of the fear of death might be the surprising first step to truly living. Check out Dr. Karlfeldt's new book A Better Way to Treat Cancer and visit The Karlfeldt Center for more resources. The post Rethinking Cancer: The Latest Tools, Tests & Treatments – Episode 198: Dr. Michael Karlfeldt, ND first appeared on Ann Louise Gittleman, PhD, CNS.

In this episode of The Nurse Practitioner Podcast, Julia Rogers, DNP, APRN, CNS, FNP-BC, FAANP and Scarlet Spain, DNP, MPH, APRN, CNS, FNP-BC discuss international collaborations.

Send us a textIn this episode of the WTR Small-Cap | Biotech Spotlight Crossover, Water Tower Research's Tim Gerdeman is joined by Dr. Chris Witowski, CEO of Psilera, and WTR Senior Analyst Robert Sassoon for an insightful discussion on the company's pioneering work in neuroplastogen drug development and delivery technologies.Dr. Chris  Witowski, CEO and Co-Founder of Psilera, an early-stage biotech company focused on developing next-generation neuroplastegens for neurological and neuropsychiatric disorders, shares his thoughts and insights on the evolution of biomarkers in the neurosciences, the latest developments and trends in CNS-focused biomarkers and the potentially transformative impact they will have on the CNS treatment landscape.Tune in to learn more about Psilera's vision for the future of neurotherapeutics and how the company is working to transform the treatment landscape for CNS disorders.

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: 7 natural ways to crush chronic inflammation and pain. (1:32) The benefits of regular napping. (21:50) Overactive bladder syndrome. (28:25) Green tea consumption = higher testosterone. (35:48) If you were stranded on an island, would you rather be by yourself or with your worst enemy? (36:40) Adam's Best Buy fiasco. (43:11) Sodium, low-carb diets, and performance. (47:42) Previewing Sal's upcoming YouTube series. (49:54) Mind Pump is looking for trainers. Apply today! (53:24) #ListenerLive question #1 – Is MAPS Muscle Mommy the right program for me being 14 months post-partum? If I'm only lifting 3 days a week and not looking to do extra work from home, are the trigger sessions necessary? (54:10) #ListenerLive question #2 – How can someone in a cut still feel confident about their progress when the scale isn't moving? (1:10:22) #ListenerLive question #3 – How would you go about actively inspiring reform and rebuilding a community for people who are so set in their ways? (1:18:57) #ListenerLive question #4 – Is there anything I can do to build a more resilient CNS or recover better so I don't need those rest weeks as often? (1:36:20) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit NED for an exclusive offer for Mind Pump listeners! ** Code MINDPUMP at checkout for 20% off ** Get your free Sample Pack with any “drink mix” purchase! Find your favorite LMNT flavor, or share it with a friend. Try LMNT risk-free. If you don't like it, give it away to a salty friend and we'll give you your money back, no questions asked! Visit DrinkLMNT.com/MindPump June Special: Shredded Summer Bundle or Bikini Bundle 50% off! ** Code JUNE50 at checkout ** The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials Importance of maintaining a low omega–6/omega–3 ratio for reducing inflammation Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 20% off** Regular Napping Linked to Increased Brain Size Mirabegron in the Treatment of Overactive Bladder Why Green Tea Could Be Your New Secret Weapon for More Testosterone TableTopics Dinner Party Question Card Game - 135 Entertaining Conversation Starter Cards for Dinner Table with Adult Friends, Getting to Know You Game. Mind Pump Personal Training – Apply today! Visit Butcher Box for this month's exclusive Mind Pump offer!  ** Available for a limited time, a curated box pre-filled with Mind Pump's favorite cuts — no guesswork! ButcherBox members who sign up through Mind Pump will receive: $20 OFF their first box, Free chicken breast, ground beef, OR salmon in every box for a whole year! ** 10 Ways To Rebuild MUSCLE & Train SAFELY After Having A Baby | Mind Pump 1882 Mind Pump #2320: Throw Away the Scale! Mind Pump #2420: Get Energized: The Real Reasons You're Always Tired & Lazy! Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Jay Campbell (@jaycampbell333) Instagram Dr. Stephen Cabral (@stephencabral) Instagram  

Since 1999, Doug Kaufmann's TV show Know the Cause has warned millions about the fungus factor most doctors overlook. Hot on the heels of Ann Louise's viral Facebook post—where she told her followers about her personal battle with mold—the two leading edge pioneers dive straight into the latest evidence about how fungi and their poisons, mycotoxins, may be fueling everything from rising PSA scores to stubborn skin flare-ups and even those stubborn coughs. Kaufmann walks listeners through a 2022 pan-cancer study that found fungal DNA in every one of 35 tumor types, explains why corn tops the mycotoxin list, and shows how our antifungal defenses weaken with age. Kaufmann outlines a no-nonsense plan: slash the sugars and refined carbs mold lives on, fortify with binders like psyllium plus immune staples such as vitamin D-3 and zinc, and confirm the problem with smart testing. His first choice is an IgM antibody screen—a quick blood draw that flags an active fungal fight—followed by a RealTime Labs urine panel and targeted cultures to pinpoint the load before treatment. If aches, brain fog, or “mystery” lab numbers refuse to budge, this conversation offers a new lens—and an action plan—to clear mold from the shadows and reclaim your health. Catch the episode, grab the steps that resonate, and learn more at KnowTheCause.com. The post The New Truth About Mold: The Silent Saboteur Behind Many Common Health Problems – Episode 197: Doug Kaufmann first appeared on Ann Louise Gittleman, PhD, CNS.

Gorilla Technology (GRRR) shares are recovering from a steep sell-off on Monday, as the company agrees to acquire Thai A.I. firms CNS and CANS. George Tsilis looks under the hood to understand the company's deal and what's driving GRRR growth this year. Shares of GRRR are up more than 900% from its 52-week low.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Fluphenazine is a high-potency typical antipsychotic that primarily acts as a dopamine D2 receptor antagonist in the mesolimbic pathway, reducing positive symptoms of schizophrenia. Extrapyramidal symptoms (EPS), such as dystonia, akathisia, and parkinsonism, are common due to potent D2 blockade in the nigrostriatal pathway. Neuroleptic malignant syndrome (NMS), though rare, is a life-threatening adverse effect characterized by rigidity, hyperthermia, altered mental status, and autonomic instability. CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) can increase fluphenazine plasma concentrations, potentially raising the risk of toxicity and side effects. Concomitant use of fluphenazine with CNS depressants (e.g., alcohol, benzodiazepines) can enhance sedation and respiratory depression.

Send us a textAmy Berger is a returning guest on our show! Be sure to check out her appearances on episode 47, episode 68, and episode 354 of Boundless Body Radio!Amy Berger, MS, CNS, is a U.S. Air Force veteran and Certified Nutrition Specialist who specializes in helping people do “Keto Without the Crazy.”™ She has a master's degree in human nutrition and writes about a wide range of health and nutrition-related topics, such as insulin, metabolism, weight loss, diabetes, thyroid function, and more.Amy is the author of The Alzheimer's Antidote: Using a Low-Carb, High-Fat Diet to Fight Alzheimer's Disease, Memory Loss, and Cognitive Decline, and The Stall Slayer: Seven Roadblocks to Keto Fat Loss and What to Do About Them. She is also the co-author of End Your Carb Confusion: A Simple Guide to Customize Your Carb Intake for Optimal Health.Amy spent years doing what nutrition and health experts claimed to lose weight but failed to experience the expected results. You can read her blog at www.tuitnutrition.com, where Amy's readers value her clever and humorous writing style, and her ability to translate scientific research jargon and gobbledygook into plain English.Find Amy at-Consultations- https://stallslayer.com/consultation/ YouTube- Tuit NutritionTW- @Tuit NutritionPatreon- Tuit Nutrition Online courses- http://adaptyourlifeacademy.com/ Funny- This Is Why Healthy Eating is Hard- Funny or DieAmy's blog post that broke my brain about gluconeogenesis!Find Boundless Body at- myboundlessbody.com Book a session with us here!

Getting a good night's sleep is something that benefits everyone. And if you're someone who's living with MS, it's perhaps even more important. But research suggests that more than half the people living with MS experience poor sleep.    Dr. Katie Siengsukon, the Director of the Sleep, Health, and Wellness Lab at the University of Kansas Medical Center Department of Physical Therapy and Rehabilitation Science, returns to the podcast to discuss the importance of good sleep hygiene, along with steps you can take to improve the quality of your sleep. We're also explaining how changes in U.S. public policy will impact people with MS. We'll tell you about an algorithm developed at Duke University that can predict (with 80-90% accuracy!) whether someone's MS symptoms will worsen in the weeks ahead. We'll share study results that show MS accelerates biological aging among children and teens with MS. We'll explain why this finding can also be applied to adults with MS, and what it means. And we'll tell you about the biotech start-up that has succeeded at bringing the brains of people who have passed away back to life, and we'll explain why that can have a major impact on CNS disease research. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: Sleep Hygiene and MS  :22 How public policy changes in the U.S. will impact people with MS  1:18 What if you knew when an MS symptom was going to worsen?  6:18 Study results show MS accelerates biological aging in children  9:04 How re-animated human brains could accelerate CNS research (And which company is doing it!)  12:00 Dr. Katie Siengsukon discusses the importance of good sleep hygiene for people living with MS  15:37 Share this episode  33:32 Have you downloaded the free RealTalk MS app?  33:52 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/407 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com Become an MS Activist https://nationalmssociety.org/advocacy Act Now! Contact Your Senators About Medicaid and Health Coverage https://nmss.quorum.us/campaign/127768 STUDY: Performance of Machine Learning Models for Predicting High-Severity Symptoms in Multiple Sclerosis https://nature.com/articles/s41598-024-63888-x STUDY: Epigenetic Aging in Pediatric-Onset Multiple Sclerosis https://neurology.org/doi/10.1212/WNL.0000000000213673 Bexorg https://bexorg.com Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 407 Guest: Dr. Katie Siengsukon Privacy Policy

Dr. Sam Berne is a super star holistic optometrist celebrated for his innovative approaches to eye health and wellness. He is the author of Vital Vision. Join The First Lady of Nutrition for an eye-opening conversation that goes far beyond glasses and eye drops.  Together, Ann Louise and Dr. Berne explore the groundbreaking idea that vision is not just about the eyes—but a dynamic connection between the brain, body, and soul. With stories of reversing cataracts, improving macular degeneration, and dissolving floaters naturally, Dr. Berne shares why you don't have to live out your doctor's diagnosis. From post-COVID vision issues to the rise in nearsightedness from screen time, this episode covers practical steps to protect and restore your eyesight—including what to do for glaucoma, night blindness, dry eyes, and more. Learn why the liver and gallbladder are critical to eye health, why early morning sunlight matters, and how simple therapies like “palming” can make a big difference. Plus, the truth about blue light, vitamin A, brain injuries, and why your glasses may be doing more harm than good. This podcast is a must-listen for anyone who wants to see life more clearly—naturally.  Learn more about Dr. Berne at https://www.drsamberne.com/. The post Casting Your New Vision – Episode 196: Dr. Sam Berne first appeared on Ann Louise Gittleman, PhD, CNS.

This episode is brought to you by Pique Teas, Z-Biotics and Caldera Lab. Dr. Brooke Scheller, DCN, CNS is back to take us on her personal journey of nearly four years without alcohol, revealing the profound impact it has had on her life and career. As she delves into the multifaceted effects of alcohol on health, including its influence on hormone balance and mental well-being, Dr. Scheller invites you to reconsider your relationship with alcohol. We explore the growing trend of "sober curious" and how societal attitudes toward alcohol consumption are shifting, especially among younger generations. By discussing the benefits of a sober lifestyle, nutrition, and the rise of non-alcoholic alternatives, Dr. Scheller challenges the stigma surrounding alcohol abstention and celebrates the empowerment that comes from choosing sobriety. Whether you're exploring sobriety or simply curious about its benefits, this episode offers valuable insights into living a healthier, alcohol-free life. Follow Brooke @drbrookescheller Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) Exploring Alcohol's Impact on Health (10:08) Rise of the Sober Curious Movement (16:39) Transitioning to Alcohol-Free Life (27:57) Navigating Social Changes Without Alcohol (33:13) Alcohol's Impact on Hormones (45:37) Brooke's Personal Reflection and Choice to Go Alcohol-Free (56:45) Emerging World of Non-Alcoholic Beverages (01:09:39) Other Benefits of Alcohol-Free Living (01:19:11) Rethinking Alcohol's Impact on Health (01:24:12) What Modern Functional Sobriety and Wellness Really Looks Like ----- Episode resources: Get 20% off FOR LIFE of the best teas at https://www.PiqueLife.com/everforward  Save 10% on the drink before your drink with code EVERFORWARD10 at https://www.ZBiotics.com/everforward10  Save 20% on Father's Day skincare with code EVERFORWARD at https://www.CalderaLab.com Watch and subscribe on YouTube Brooke's first appearance in EFR 785: How Alcohol Affects Your Gut Microbiome, Brain Health, Hormones, Lowers Fertility, and How to Eat to Change How You Drink and watch on YouTube here